CN108211135A - Radiotherapy multispectral imaging device - Google Patents
Radiotherapy multispectral imaging device Download PDFInfo
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- CN108211135A CN108211135A CN201711387480.1A CN201711387480A CN108211135A CN 108211135 A CN108211135 A CN 108211135A CN 201711387480 A CN201711387480 A CN 201711387480A CN 108211135 A CN108211135 A CN 108211135A
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- ccd
- detector
- multispectral imaging
- radiotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1059—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using cameras imaging the patient
Abstract
The invention discloses a kind of radiotherapy multispectral imaging devices, including the detector that is connected with X-ray emission device, the detector includes being packaged in shell for acquiring four groups of CCD of Cherenkov's photon, and the different filter plate of wavelength-filtered is additionally provided on every group of CCD；The detector is packaged in front of KV grades of X ray bulbs, orthogonal with MV grades of heads；At least 180 ° of the rotatable irradiation of MV grade heads of the X-ray emission device, CCD follow its rotating acquisition Cherenkov photon for being imaged.Detector acquires signal, is not influenced by accelerator rack；And MV grades of x-ray angles of detection angle and treatment are at a right angle, and do not change with treatment angulation change；Multigroup CCD uses different filter plates, and it is more accurate that multispectral imaging composes single light spectrum image-forming.
Description
Technical field
The invention belongs to radiotherapy equipment technical fields, are related to a kind of radiotherapy multispectral imaging device.
Background technology
At present, radiotherapy has become one of standard care means after tumor of breast Breast reservation.In order to reduce radiotherapy
Site error, the development of image guided radiation therapy technology are swift and violent.
2006, VARIAN Oncology Systems and Sweden's medical courses in general developed radiological imaging system up to company, in two machineries
KV-X ray tubes and one piece of large scale Amorphous silicon flat-panel detectors on arm are installed respectively, while KV images and MV shadows can be acquired
Picture.The real-time breathing tracing system of An Kerui companies of U.S. research and development, by being distributed in indoor 2 cameras and amorphous silicon detector
Composition, is merged in the form of 2D or 3D with digital image rebuilding DRR, so as to the position of the velocity estimated patient of near real-time
Variation is put, and the movement of patient is corrected in time over the course for the treatment of.But above scheme uses the side of X-ray radiation
Formula makes patient receive unnecessary dose irradiation, and can not accomplish to verify the accuracy that tumour receives dosage.
2014, VARIAN Oncology Systems and Sweden's medical courses in general were developed radiological imaging system image taking speed up to company and are being divided
Clock magnitude, and patient respiratory cycle can not accomplish the real time imagery of tumor of breast in millisecond magnitude.
2016, the C-Dose of DoseOptics companies of U.S. production was that the currently the only tumour radiotherapy that is developed to apply to is controlled
Cherenkov's luminescence imaging (Cerenkov luminescence imaging, CLI) equipment for the treatment of, when which has imaging
Between it is short, sensitivity is good, cost-effective, it is radiationless many advantages, such as, applied to tumor of breast treatment dosage imaging research in.
But since the C-Dose release times are shorter, some outstanding problems are also exposed in application process.In breast cancer treatment mistake
Cheng Zhong, detector are placed in fixed position around, and investigative range is limited, particularly in multi-angle therapeutic process, treatment angle it is more and
Variation is fast, and detector is influenced by accelerator rack, can not acquire signal；There is also similar in the intensity modulated therapy of multi-angle
The problem of, factors above limits applications of the CLI in complicated tumour radiotherapy technology.
Invention content
Present invention solves the problem in that provide a kind of radiotherapy multispectral imaging device, by acquiring radiotherapy when generates
Cherenkov's photon, to the imaging of body surface organization absorbed dose of radiation.
The present invention is to be achieved through the following technical solutions：
A kind of radiotherapy multispectral imaging device, including the detector that is connected with X-ray emission device, the detector packet
It includes and is packaged in shell for acquiring four groups of CCD of Cherenkov's photon, the different filter of wavelength-filtered is additionally provided on every group of CCD
Wave plate；
The detector is packaged in front of KV grades of X ray bulbs, orthogonal with MV grades of heads；
At least 180 ° of the rotatable irradiation of head of the X-ray emission device, CCD follows its rotating acquisition Cherenkov
Photon is used to be imaged.
The detection angle of the detector and the MV grade x-ray angles of X-ray emission device are at a right angle, and are not penetrated with MV grades
Line angulation change and change.
Every group of CCD acquires Cherenkov's photon when head rotating is followed to irradiate, comprehensive four groups of different wave lengths
It acquires information and is used for multispectral imaging.
The wavelength-filtered of filter plate is respectively used by the CCD：515-575nm, 575-650nm, 695-
770nm and 810-875nm, four groups of filter plates according to arranging successively clockwise.
In multispectral imaging, to information combination superposition, four discrete spectrums obtained by the different wavelength-filtereds of every group of CCD
The ratio that optical signal intensity on 515-575nm, 575-650nm, 695-770nm and 810-875nm accounts for entire frequency spectrum is
0.572,0.276,0.124 and 0.028.
Compared with prior art, the present invention has technique effect beneficial below：
Radiotherapy multispectral imaging device provided by the invention, while roentgenotherapia tumour, with body surface phase interaction
With.While External absorbability X ray, with 60 degree of the angle of divergence, emit Cherenkov's photon.Camera CCD can acquire Cherenkov
Photon two-dimensional imaging.Because Cherenkov's photon relationship proportional to body surface organization absorbed dose of radiation, Cherenkov's photon X-Y scheme
As can be exchanged into two-dimentional dosage imaging.
Radiotherapy multispectral imaging device provided by the invention, is packaged in due to detector in the head of X-ray emission device,
It can be during multi-angle roentgenotherapia with head rotating, so its detector acquires signal, not by accelerator rack
It influences；And MV grades of x-ray angles of detection angle and treatment are at a right angle, and do not change with treatment angulation change；Multigroup CCD is adopted
With different filter plates, it is more accurate that multispectral imaging composes single light spectrum image-forming.
Radiotherapy multispectral imaging device provided by the invention, the hardware configuration that this project is combined using CCD and filter plate, is adopted
With the hardware of four CCD+ filter plates, orthogonal four positions are positioned over, respectively the two-dimentional dosage imaging of acquisition, human relations are cut using mixed spectrum
Multigroup two dimensional image is redeveloped into 3-D view by section husband luminescence imaging method.This imaging method has the advantages that quick, three-dimensional
Image can move at any time, form four-dimensional dynamic surface dose imaging.
The present invention collects Cherenkov's photon imaging that tumour radiotherapy process itself generates, and does not utilize additional ray
Patient is irradiated, interference is not generated to the treatment of patient, accomplishes radiationless, noninvasive dosage imaging.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the panel detector structure schematic diagram of the present invention；
Fig. 3 is tumour radiotherapy imaging results.
Wherein, 1 is MV grades of X ray head CCD of outgoing；2 be KV grades of X ray bulbs of outgoing；3 be detector；4 be CCD；5
For filter plate.
Specific embodiment
With reference to specific embodiment, the present invention is described in further detail, it is described be explanation of the invention and
It is not to limit.
As shown in Figure 1 and Figure 2, a kind of radiotherapy multispectral imaging device, including the detector that is connected with X-ray emission device,
The detector includes being packaged in shell for acquiring four groups of CCD of Cherenkov's photon, and filtering is additionally provided on every group of CCD
The different filter plate of wavelength；
The detector is packaged in front of KV grades of X ray bulbs, orthogonal with MV grades of heads；
At least 180 ° of the rotatable irradiation of MV grade heads of the X-ray emission device, CCD follows its rotating acquisition to cut human relations
Section's husband's photon is used to be imaged.
Further, the detection angle of the detector and the MV grade x-ray angles of X-ray emission device are at a right angle, and not
Change with MV grades of x-ray angles and change.
Every group of CCD acquires Cherenkov's photon when head rotating is followed to irradiate, comprehensive four groups of different wave lengths
It acquires information and is used for multispectral imaging.
The wavelength-filtered of filter plate is respectively used by the CCD：
515-575nm, 575-650nm, 695-770nm and 810-875nm, four groups of filter plates according to arranging successively clockwise
Cloth.
Specifically, in multispectral imaging, to information combination superposition obtained by the different wavelength-filtereds of every group of CCD, four from
Dissipate the ratio that the optical signal intensity on frequency spectrum 515-575nm, 575-650nm, 695-770nm and 810-875nm accounts for entire frequency spectrum
Example is 0.572,0.276,0.124 and 0.028.
As shown in Fig. 2, being sky among detector parts, X ray bulb transmitting X ray is not influenced.Detector wall material simultaneously
Expect for alloy material, shielding X ray, the influences of KV grades and MV grades rays of elimination；Human body during the CCD acquisition radiotherapies of detector
Cherenkov's photon of generation, to body surface organization's absorbed dose of radiation imaging；CCD imagings need to imported on computer, are carried by CCD
Software LightField (Princeton University's instrument, Trenton, New Jersey) display.
Some design parameters of CCD are given below.
Specific occupation mode is given below：
1st, before tumour radiotherapy starts, the combination of detector is selected, selects imaging pattern.
2nd, detector switch is opened in software, it is standby.
3rd, tumour radiotherapy starts, and can show that body surface exposure dose is imaged in software, imaging results are as shown in Figure 3.
Example given above is to realize the present invention preferably example, and the present invention is not limited to above-described embodiments.This field
Technical staff any nonessential addition, the replacement made according to the technical characteristic of technical solution of the present invention, belong to this
The protection domain of invention.
Claims (5)
1. a kind of radiotherapy multispectral imaging device, which is characterized in that described including the detector that is connected with X-ray emission device
Detector include being packaged in shell for acquiring four groups of CCD of Cherenkov's photon, be additionally provided with wavelength-filtered on every group of CCD
Different filter plates；
The detector is packaged in front of KV grades of X ray bulbs, orthogonal with MV grades of heads；
At least 180 ° of the rotatable irradiation of MV grade heads of the X-ray emission device, CCD follows its rotating acquisition Cherenkov
Photon is used to be imaged.
2. radiotherapy multispectral imaging device as described in claim 1, which is characterized in that the detection angle and X of the detector
The MV grade x-ray angles of radiation-emitting device are at a right angle, and do not change with MV grades of x-ray angles and change.
3. radiotherapy multispectral imaging device as described in claim 1, which is characterized in that every group of CCD is following head
Cherenkov's photon is acquired during rotary irradiation, the acquisition information of comprehensive four groups of different wave lengths is used for multispectral imaging.
4. the radiotherapy multispectral imaging device as described in claim 1 or 3, which is characterized in that filtered used by the CCD
The wavelength-filtered of piece is respectively：515-575nm, 575-650nm, 695-770nm and 810-875nm, four groups of filter plates are according to suitable
Hour hands are arranged successively.
5. the radiotherapy multispectral imaging device as described in claim 1 or 3, which is characterized in that in multispectral imaging, to every group
Information combination superposition obtained by the different wavelength-filtereds of CCD, four discrete spectrums 515-575nm, 575-650nm, 695-770nm and
The ratio that optical signal intensity on 810-875nm accounts for entire frequency spectrum is 0.572,0.276,0.124 and 0.028.
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| CN110478630A (en) * | 2019-09-06 | 2019-11-22 | 江苏瑞尔医疗科技有限公司 | A kind of imaging device for radiotherapy system |
| CN114984462A (en) * | 2022-04-15 | 2022-09-02 | 南京航空航天大学 | Cerenkov light dose monitoring method and device based on multi-channel imaging |
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| CN108211135B (en) | 2020-05-12 |
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