CN106491094A - A kind of medical radionuclide imaging system based on radiofluorescence material coated plate - Google Patents
A kind of medical radionuclide imaging system based on radiofluorescence material coated plate Download PDFInfo
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- CN106491094A CN106491094A CN201611083821.1A CN201611083821A CN106491094A CN 106491094 A CN106491094 A CN 106491094A CN 201611083821 A CN201611083821 A CN 201611083821A CN 106491094 A CN106491094 A CN 106491094A
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- radiofluorescence
- material coated
- imaging
- coated plate
- array detector
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
Abstract
The present invention provides a kind of medical radionuclide imaging system based on radiofluorescence material coated plate to be included：Energy change-over panel, detection device control imaging device, lucifuge camera bellows；Radiation fluorescent material coated plate is coordinated to realize that medical radionuclide medicine is imaged using CCD camera, the nuclear medical imaging apparatus such as the PET and SPECT technology commonly used relative to clinic/pre- clinic and γ cameras reduce equipment by a relatively large margin and build and maintenance cost, reduce the threshold of nuclear medicine research, system cost is reduced relative to PET and SPECT imaging methods simultaneously, is easy to promote.
Description
Technical field
The present invention relates to a kind of imaging system, belongs to medical field, specifically refer to a kind of based on radiofluorescence material coated plate
Medical radionuclide imaging system.
Background technology
Radionuclide drug imaging technique is referred to radionuclide or radionuclide as a kind of Imaging Technology
Certain compound of mark introduces (intravenous injection is oral) organism, has using some tissues or organ of organism
Selective absorbing or the function of dense poly- radioactive compound, treat introduced radionuclide drug privileged site in vivo
After convergence, technology that radionuclide drug in organism is imaged.At present, positron emission is clinically widely used
Computerized tomograph (Positron Emission Computed Tomography, abbreviation PET) and single photon emission are calculated
Machine tomography (Single-Photon Emission Computed Tomography, abbreviation SPECT) comes in organism
Radionuclide drug be imaged：The gamma-rays that produces carry out one and be in decay by detectable radionuclide medicine
Column count, final acquisition radionuclide drug locus distributed intelligence in vivo.So far, PET and SPECT
It is still the strong instrument of development mechanism for the treatment of, research, the biological in-vivo tumour of monitoring.However, either PET is still
SPECT, all costly, this significantly limit radionuclide drug imaging technique in basic medical research to its use cost
Field widely uses.
Cherenkov's fluorescence imaging (Cerenkov Luminescence Imaging, abbreviation CLI) is a kind of emerging putting
Penetrating property nucleic medicine imaging technique, the technology carry out detectable radionuclide medicine in nuclear decay by using optical imaging apparatus
During the visible ray that produces and near infrared light signal, and then the radionuclide drug in organism is imaged.Compare
PET and SPECT technology, CLI technical costs is cheap, Imaging fast and easily operated.However, CLI technology can only collect radiation
Optical profile information of the Cherenkov's fluorescence signal that property nucleic medicine is sent in organism surface, it is impossible to describe radioactive nucleus
The locus distributed intelligence in plain medicine portion in vivo.
In order to obtain radionuclide drug locus distributed intelligence in vivo, researchers are based on CLI skills
Art proposes Cherenkov's fault imaging (Cerenkov Luminescence Tomography, abbreviation CLT) technology.Such as China
Institute of Automation Tian Jie team of the academy of sciences is in its application for a patent for invention file " tomograph imaging method based on Cerenkov effect ", Shen
Please number for 201080059913.0 PCT Patent in propose a kind of CLT methods, by using high-order simplify spherical harmonic approximation model
The method being coupled with half threshold operator of iteration, it is achieved that radionuclide drug in vivo part cloth two-dimentional tomography into
Picture.But, Cherenkov's fluorescence signal that the imaging method is built upon sending when radionuclide drug decays can be passed through
Biological tissue reaches organism surface and is optically imaged on the basis of equipment detects.When decaying as radionuclide drug
Secondary species, Cherenkov's fluorescence signal intensity is very weak, along with decay shadow of the biological tissue to Cherenkov's fluorescence signal
Ring than more serious, so, when radionuclide drug is located at organism deep place, Cherenkov's fluorescence signal is difficult to reach
Organism surface is detected by optical device.
Content of the invention
It is an object of the invention to provide a kind of medical radionuclide imaging system based on radiofluorescence material coated plate,
To solve in prior art, in Cherenkov's fluorescence imaging, Cherenkov's fluorescence signal is difficult to reach organism surface by optical device
The problem for being detected, while reduce system cost relative to PET and SPECT imaging methods.
To achieve these goals, the present invention provide a kind of medical radionuclide based on radiofluorescence material coated plate into
As system includes：
Energy change-over panel, the high-energy ray produced during for medical radionuclide decaying are changed into radiofluorescence letter
Number；
Detection device, the white light signal for the radiofluorescence signal that sends energy change-over panel and organism surface turn
Turn to electric signal；
Control imaging device, for carrying out subsequent treatment to the electric signal after the conversion, acquisition biology is medical in vivo to be put
Two-dimensional position information and distributed intelligence of the penetrating property nucleic corresponding to its surface, the control imaging device are connected with the detection device
Connect,；
Lucifuge camera bellows, connects the energy change-over panel and detection device, it is to avoid radiofluorescence signal is passed by energy change-over panel
It is delivered to detection device process to be disturbed by extraneous optical signalling.
Wherein, the energy change-over panel includes radiofluorescence material coated plate and lead hole collimating plate, the radiofluorescence material
Coated plate is brought into close contact with lead hole collimating plate.
Wherein, the detection device includes imaging len and planar array detector, affiliated radiofluorescence signal and white light
Signal focuses to the planar array detector through imaging len, and optical signalling is converted into electric signal transmission by the planar array detector
To the control imaging device.
Wherein, the control imaging device includes planar array detector control card and coupled computer, described
Planar array detector control card is connected with planar array detector.
Wherein, the planar array detector is CCD camera or CMOS cameras.
Wherein, the one side of the energy change-over panel is located in the detection device on the focal plane of imaging len.
A kind of imaging method of the medical radionuclide imaging system based on radiofluorescence material coated plate, including following step
Suddenly：
(1) White-light image acquisition phase：
(1a) energy change-over panel is removed from lucifuge camera bellows；
(1b) white light signal of organism surface focuses to the planar array detector through the imaging len；
(1c) planar array detector converts optical signal into electric signal transmission to imaging device is controlled, and obtains organism surface
White-light image；
(2) radiofluorescence image acquisition phase：
(2a) by the energy reformer plate installed in the lucifuge camera bellows side corresponding with the detection device；
(2b) high-energy ray that the medical radionuclide decay inside organism is produced is arrived through lead hole collimating plate
Up to radiofluorescence material coated plate, radiofluorescence material is excited to send radiofluorescence；
(2c) radiofluorescence focuses to the planar array detector through the imaging len；
(2d) radiofluorescence signal is converted into electric signal transmission to imaging device is controlled by the planar array detector, is put
Penetrate fluoroscopic image；
(3) the image co-registration stage：
The White-light image collected by step (1c) and step (2d) and radiofluorescence image, carry out figure on computers
As denoising and fusion treatment, fused images of attaining the Way；
(4) position and the distributed intelligence of medical radionuclide are obtained：
The fused images obtained based on step (3), obtain biological medical radionuclide corresponding to its surface two in vivo
Dimension positional information and distributed intelligence.
The beneficial effects of the present invention is：
1st, the present invention coordinates radiation fluorescent material coated plate to realize that medical radionuclide medicine is imaged using CCD camera, phase
The nuclear medical imaging apparatus such as the PET and SPECT technology commonly used for clinic/pre- clinic and γ cameras are reduced by a relatively large margin
Equipment is built and maintenance cost, reduces the threshold of nuclear medicine research；
2nd, the CCD camera that present invention employs lower cost coordinates radiation fluorescent material coated plate to realize medical radionuclide
Medicine is imaged, the nuclear medical imaging apparatus such as the PET and SPECT technology commonly used relative to clinic/pre- clinic and γ cameras, damages
Certain sensitivity and imaging precision is lost, but has been compared with existing CLI technology, due to detection has been by with high biology
The high-energy ray of penetration into tissue excites the radiofluorescence of gained, and such ray when propagating in biological tissues hardly
There is the change of transmission direction, so the sensitivity of the present invention and imaging precision can be higher than existing CLI technology.
Description of the drawings
Fig. 1 present system composition schematic diagrams；
Fig. 2 is the flow chart of imaging system using method of the present invention；
Pre- clinical trial results of the Fig. 3 for the embodiment of the present invention.
Specific embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with drawings and Examples, right
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only in order to explain the present invention, not
For limiting the present invention.
As shown in figure 1, a kind of medical radionuclide imaging system based on radiofluorescence material coated plate includes：Energy turns
Plate 1 is changed, the high-energy ray produced during for medical radionuclide decaying is changed into radiofluorescence signal；
Detection device 2, for the radiofluorescence signal that sends the energy change-over panel 1 and the white light of organism surface
Signal is converted into electric signal；
Control and imaging device 3, are connected with the detection device 2, for carrying out subsequently to the electric signal after the conversion
Process, obtain two-dimensional position information and distributed intelligence of the biological medical radionuclide in vivo corresponding to its surface；
Lucifuge camera bellows 4, connection energy change-over panel 1 and detection device 2, it is to avoid radiofluorescence signal is transmitted by energy change-over panel
Disturbed to detection device process by extraneous optical signalling.
It should be noted that affiliated energy change-over panel 1, including radiofluorescence material coated plate 11 and lead hole collimating plate 12, its
In, together with lead hole collimating plate 12 is brought into close contact with radiofluorescence material coated plate 11.
It should be noted that affiliated detection device 2, including imaging len 21 and planar array detector 22, affiliated radiation is glimmering
Optical signal and white light signal focus to the planar array detector 22 through imaging len 21, then have the planar array detector 22 to incite somebody to action
Optical signalling is converted into electric signal transmission to the control and imaging device 3.
It should be noted that the control includes planar array detector control card 31 with imaging device 3, and coupled
Computer 32, wherein, the planar array detector control card 31 is connected with planar array detector 32.
Used as a kind of preferred version, the planar array detector 22 is CCD camera or CMOS cameras.
Need it is further noted that the one side of the energy change-over panel 1 is located at imaging len 21 in the detection device 2
Focal plane on.
As shown in Fig. 2 a kind of imaging method of the medical radionuclide imaging system based on radiofluorescence material coated plate,
Comprise the following steps：
(1) White-light image acquisition phase：
(1a) energy change-over panel is removed from lucifuge camera bellows；
(1b) white light signal of organism surface focuses to the planar array detector through the imaging len；
(1c) planar array detector converts optical signal into electric signal transmission to imaging device is controlled, and obtains organism surface
White-light image；
(2) radiofluorescence image acquisition phase：
(2a) by the energy reformer plate installed in the lucifuge camera bellows side corresponding with the detection device；
(2b) high-energy ray that the medical radionuclide decay inside organism is produced is arrived through lead hole collimating plate
Up to radiofluorescence material coated plate, radiofluorescence material is excited to send radiofluorescence；
(2c) radiofluorescence focuses to the planar array detector through the imaging len；
(2d) radiofluorescence signal is converted into electric signal transmission to imaging device is controlled by the planar array detector, is put
Penetrate fluoroscopic image；
(3) the image co-registration stage：
The White-light image collected by step (1c) and step (2d) and radiofluorescence image, carry out figure on computers
As denoising and fusion treatment, fused images of attaining the Way；
(4) position and the distributed intelligence of medical radionuclide are obtained：
The fused images obtained based on step (3), obtain biological medical radionuclide corresponding to its surface two in vivo
Dimension positional information and distributed intelligence.
It should be noted that the medical radionuclide medicine in toy body is18F-FDG nucleic probes, excite radiation
It is art technology produced by the radionuclide decay in the probe that fluorescent material sends the high-energy ray of radiofluorescence
Personnel are appreciated that medical radionuclide medicine can also be Na131I nucleic probes etc..
The pre- clinical trial results of the embodiment of the present invention are illustrated in figure 3, volunteer's Patients with Hyperthyroidism, the medical of employing are put
Penetrating property nucleic medicine is Na131I.After traditional SPECT diagnosis of scans is carried out to volunteer, using imaging proposed by the present invention
System carries out signals collecting according to imaging method proposed by the present invention, obtains its table corresponding of medical radionuclide inside thyroid gland
The two-dimensional position information in face and distributed intelligence.Can see, medical radioactive inside the thyroid gland acquired using the present invention
The two-dimensional position information on nucleic its surface corresponding has preferably consistent with distributed intelligence and clinically SPECT diagnosis of scans result
Property.
For a person skilled in the art, technical scheme that can be as described above and design, make other each
Plant corresponding change and deform, and all these changes and deforms the protection model that should all belong to the claims in the present invention
Within enclosing.
Claims (7)
1. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate, it is characterised in that the system bag
Include：
Energy change-over panel, the high-energy ray produced during for medical radionuclide decaying are changed into radiofluorescence signal；
Detection device, the white light signal for the radiofluorescence signal that sends energy change-over panel and organism surface are converted into
Electric signal；
Control imaging device, for carrying out subsequent treatment to the electric signal after the conversion, obtains biological medical radioactive in vivo
Two-dimensional position information and distributed intelligence of the nucleic corresponding to its surface, the control imaging device are connected with the detection device,；
Lucifuge camera bellows, connects the energy change-over panel and detection device, it is to avoid radiofluorescence signal is delivered to by energy change-over panel
Detection device process is disturbed by extraneous optical signalling.
2. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate according to claim 1, its
It is characterised by, the energy change-over panel includes radiofluorescence material coated plate and lead hole collimating plate, the radiofluorescence material coated plate
It is brought into close contact with lead hole collimating plate.
3. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate according to claim 1, its
It is characterised by, the detection device includes imaging len and planar array detector, affiliated radiofluorescence signal and white light signal
The planar array detector is focused to through imaging len, optical signalling is converted into electric signal transmission to institute by the planar array detector
State control imaging device.
4. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate according to claim 1, its
It is characterised by, the control imaging device includes planar array detector control card and coupled computer, the face battle array
Detector control card is connected with planar array detector.
5. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate according to claim 1, its
It is characterised by, the planar array detector is CCD camera or CMOS cameras.
6. a kind of medical radionuclide imaging system based on radiofluorescence material coated plate according to claim 1, its
It is characterised by, the one side of the energy change-over panel is located in the detection device on the focal plane of imaging len.
7. the medical radionuclide described in a kind of utilization claim 1-6 any one based on radiofluorescence material coated plate is imaged
The imaging method of system, it is characterised in that the method comprising the steps of：
(1) White-light image acquisition phase：
(1a) energy change-over panel is removed from lucifuge camera bellows；
(1b) white light signal of organism surface focuses to the planar array detector through the imaging len；
(1c) planar array detector converts optical signal into electric signal transmission to imaging device is controlled, and obtains the white of organism surface
Light image；
(2) radiofluorescence image acquisition phase：
(2a) by the energy reformer plate installed in the lucifuge camera bellows side corresponding with the detection device；
(2b) high-energy ray that the medical radionuclide decay inside organism is produced is reached through lead hole collimating plate and is put
Fluorescent material coated plate is penetrated, excites radiofluorescence material to send radiofluorescence；
(2c) radiofluorescence focuses to the planar array detector through the imaging len；
(2d) radiofluorescence signal is converted into electric signal transmission to imaging device is controlled by the planar array detector, obtains radiation glimmering
Light image；
(3) the image co-registration stage：
The White-light image collected by step (1c) and step (2d) and radiofluorescence image, carry out image on computers and go
Make an uproar and fusion treatment, fused images of attaining the Way；
(4) position and the distributed intelligence of medical radionuclide are obtained：
The fused images obtained based on step (3), obtain biological Two-dimensional Position of the medical radionuclide corresponding to its surface in vivo
Confidence breath and distributed intelligence.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107569210A (en) * | 2017-07-25 | 2018-01-12 | 西北大学 | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding |
| CN108211135A (en) * | 2017-12-20 | 2018-06-29 | 西安交通大学医学院第附属医院 | Radiotherapy multispectral imaging device |
| CN109254310A (en) * | 2018-10-17 | 2019-01-22 | 苏州瑞派宁科技有限公司 | Detection device, the imaging system including the detection device and its detection method |
| CN114587480A (en) * | 2022-03-23 | 2022-06-07 | 中国人民解放军火箭军特色医学中心 | Aorta blocking balloon device based on 18F-FDG detection and positioning |
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| CN105105697A (en) * | 2015-07-03 | 2015-12-02 | 西安电子科技大学 | Medical endoscopic radiation luminescence imaging system and imaging method thereof |
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| CN101317765A (en) * | 2008-05-23 | 2008-12-10 | 新奥博为技术有限公司 | Double-mode imaging system of integral radio nuclide imaging and fluorescence imaging |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107569210A (en) * | 2017-07-25 | 2018-01-12 | 西北大学 | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding |
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| CN114587480A (en) * | 2022-03-23 | 2022-06-07 | 中国人民解放军火箭军特色医学中心 | Aorta blocking balloon device based on 18F-FDG detection and positioning |
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