CN105011956A - Optical imaging system for medical radionuclide and medical nuclide detection method - Google Patents
Optical imaging system for medical radionuclide and medical nuclide detection method Download PDFInfo
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- CN105011956A CN105011956A CN201510233144.6A CN201510233144A CN105011956A CN 105011956 A CN105011956 A CN 105011956A CN 201510233144 A CN201510233144 A CN 201510233144A CN 105011956 A CN105011956 A CN 105011956A
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Abstract
Provided is an optical imaging system for medical radionuclide. The optical imaging system comprises a gamma ray luminescent material coated plate, a light-blocking channel, a high-performance optical camera and a system support. The gamma ray luminescent material coated plate is coated with rare earth material which is excited by a gamma ray so as to be capable of producing a fluorescence signal and used for converting the gamma ray to the fluorescence signal acquired by the high-performance optical camera. The light-blocking channel can provide an enclosed optical path channel for the high-performance optical camera in order to avoid external interference of ambient light. The gamma ray luminescent material coated plate is installed at the top end of the light-blocking channel. The high-performance optical camera is used for acquiring an optical signal produced by the gamma ray luminescent material coated plate. The system support is used for bearing the gamma ray luminescent material coated plate, the light-blocking channel and the high-performance optical camera and can elevate in order to adjust heights of gamma ray luminescent material coated plate, the light-blocking channel and the high-performance optical camera.
Description
Technical field
The present invention relates to a kind of optical imaging system of medical radionuclide and medical nucleic detection method.More specifically, it relates to a kind of based on gamma-rays luminescent material coated plate medical nucleic detection system and medical nucleic detection method.
Background technology
To the detection extensive use radio nuclide imaging method of human carcinoma.To conventional medical radionuclide imaging, both directly can carry out radio nuclide imaging with nucleic detecting devices, can Cherenkov's optical imagery be carried out again.Positron emission tomography, single photon emission computerized tomography and utilize gamma camera imaging to be direct radio nuclide imaging, but this type of imaging pattern has the shortcomings such as γ photon detection apparatus expensive used, acquisition time be longer; Cherenkov's optical imagery is the very faint Cherenkov light of signal due to detection, adopts general optical camera to be difficult to collect optical signalling, requires very harsh to the lucifuge of imaging circumstances.
Summary of the invention
The object of this invention is to provide a kind of optical imaging system of medical radionuclide, it comprises, lucifuge passage, high-performance optical camera and system frame;
Described lucifuge passage provides an airtight path channels for high-performance optical camera, and gamma-rays luminescent material coated plate is equipped with on described lucifuge passage top, described gamma-rays luminescent material coated plate scribbles and excites the rare earth material that can produce fluorescence signal by gamma-rays, for gamma-rays being converted to the fluorescence signal that described high-performance optical camera can gather;
High-performance optical camera, the optical signal that described high-performance optical camera produces for gathering described gamma-rays luminescent material coated plate;
System frame, for carrying described lucifuge passage and high-performance optical camera, described system frame can be elevated, to regulate the height of described lucifuge passage and high-performance optical camera simultaneously.
On the basis of technique scheme, described fluorescent material is gadolinium oxysulfide rare earth.
On the basis of technique scheme, described fluorescent material is the mixture of gadolinium oxysulfide rare earth and viscosity crystal glue-dropping.
On the basis of technique scheme, the described medical nucleic detection system based on gamma-rays luminescent material coated plate also comprises a system frame, and described lucifuge passage and described high-performance camera are located in described system frame.
On the basis of technique scheme, described system frame comprises base, is installed on the elevating lever on base, and is mounted on the object stage on described elevating lever.
On the basis of technique scheme, described lucifuge passage is connected with described high-performance camera, and described lucifuge passage and described high-performance camera are on the same line.
On the basis of technique scheme, described lucifuge passage comprises main channel, sealing silica gel, camera fixed cap, described main channel comprises contact skin end and the camera installation end relative with described contact skin end, and described sealing silica gel is installed on described contact skin end, described camera fixed cap is installed on described camera installation end.
On the basis of technique scheme, described gamma-rays luminescent material coated plate is positioned over contact skin end, and described sealing silica gel can be fitted with human body skin, and described camera fixed cap is fixed with high-performance camera.
The present invention also provides a kind of medical nucleic detection method, and it comprises the following steps,
Step 1: be coated with on gamma-rays luminescent material coated plate and excite the fluorescent material that can produce fluorescence signal by gamma-rays;
Step 2: lucifuge passage is closely leaned against the position to be detected that injection has the patient to be detected of diagnosis radioisotope labeling medicine;
Step 3: gather fluorescence signal by optical CCD camera.
Beneficial effect of the present invention is: owing to using high-performance phase function to accelerate image taking speed greatly, and use fluorescence mass-energy to effectively reduce cost.
Accompanying drawing explanation
Fig. 1 is detection system general frame schematic diagram of the present invention;
Fig. 2 is that each module part splits detail drawing;
Fig. 3 is native system concrete operation step schematic diagram.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.
Please refer to Fig. 1-Fig. 2, the invention provides a kind of optical imaging system of medical radionuclide, the optical imaging system of this medical radionuclide is made up of system frame 1, high-performance optical camera 2 and lucifuge passage 3.
System frame comprises base 10, is installed on the elevating lever 11 on base 10, and is mounted on the object stage 12 on elevating lever 11, and object stage 12 is provided with high-performance optical camera 2 and lucifuge passage 3.Elevating lever 11 can drive object stage 12 to move up and down, to adjust the height of high-performance optical camera 2 and lucifuge passage 3, to match with people's height to be detected.
Lucifuge passage 3 comprises main channel 30, sealing silica gel 31, camera fixed cap 32, main channel 30 comprises contact skin end 33 and the camera installation end 34 relative with described contact skin end 33, and sealing silica gel peace 31 is loaded on described contact skin end 33, camera fixed cap 32 is installed on described camera installation end 34.
Gamma-rays luminescent material coated plate 35 the contact skin end 33 of lucifuge passage 3 is equipped with, the light interference in external world when sealing silica gel 31 can avoid human body to be attached on lucifuge passage.Ensure that the gamma-rays luminescent material coated plate 35 of installing on contact skin end 33 receives only from injecting the fluorescence signal having the position to be detected place of the patient to be detected of diagnosis radioisotope labeling medicine to excite.
Gamma-rays luminescent material coated plate 35 scribbles and excites the rare earth material that can produce fluorescence signal by gamma-rays, for gamma-rays being converted to the fluorescence signal that described high-performance optical camera can gather, fluorescent material is the mixture of gadolinium oxysulfide rare earth or gadolinium oxysulfide rare earth and viscosity crystal glue-dropping.
High-performance optical camera 2 is fixed on the camera fixed cap 32 of lucifuge passage 3, is interconnected between lucifuge passage 3 and high-performance camera 2 meanwhile.Lucifuge passage 3 and high-performance camera 2 on the same line, make the optical signal in lucifuge passage 3 can directly catch by high-performance optical camera 2.And the area optical be connected with lucifuge passage 3 at high-performance optical camera 2 is airtight, lucifuge passage 3 provides an airtight path channels for high-performance optical camera 2, avoids external light influence testing result.When patient to be detected is attached on the sealing silica gel 31 of lucifuge passage 3, and when high-performance optical camera 2 is fixed on the camera fixed cap 32 of lucifuge passage 3, the region to be detected of human body, lucifuge passage 3 and high-performance camera 2 three form a space airtight with external optical jointly.The fluorescence that the direct recipient's in-vivo diagnostic radioisotope labeling medicine of high-performance camera 2 excites also carries out imaging.Owing to using high-performance camera imaging exposure period, image taking speed can be accelerated greatly, and use fluorescence mass-energy to effectively reduce cost.
Introduce the method using the optical imaging system of medical radionuclide of the present invention to carry out medical nucleic detection below, please refer to Fig. 3, a kind of method that the present invention also provides medical nucleic to detect, it comprises the following steps,
Step 1: be coated with on gamma-rays luminescent material coated plate 35 and excite the fluorescent material that can produce fluorescence signal by gamma-rays;
Step 2: lucifuge passage 3 is closely leaned against the position to be detected that injection has the patient to be detected of diagnosis radioisotope labeling medicine;
Step 3: gather fluorescence signal with high-performance camera 2.
The present invention uses the high-performance camera 2 Imagewise exposure time period, can accelerate image taking speed greatly, and uses fluorescence mass-energy to effectively reduce cost.Meanwhile, the region to be detected of human body, lucifuge passage and high-performance camera three form a space airtight with external optical jointly, have good certainty of measurement and accuracy.
For a person skilled in the art, according to technical scheme described above and design, other various corresponding change and distortion can be made, and all these change and distortion all should belong within the protection domain of the claims in the present invention.
Claims (8)
1. an optical imaging system for medical radionuclide, is characterized in that: it comprises, lucifuge passage, high-performance optical camera and system frame;
Described lucifuge passage provides an airtight path channels for high-performance optical camera, and gamma-rays luminescent material coated plate is equipped with on described lucifuge passage top, described gamma-rays luminescent material coated plate scribbles and excites the rare earth material that can produce fluorescence signal by gamma-rays, for gamma-rays being converted to the fluorescence signal that described high-performance optical camera can gather;
High-performance optical camera, the optical signal that described high-performance optical camera produces for gathering described gamma-rays luminescent material coated plate;
System frame, for carrying described lucifuge passage and high-performance optical camera, described system frame can be elevated, to regulate the height of described lucifuge passage and high-performance optical camera simultaneously.
2. the optical imaging system of a kind of medical radionuclide as claimed in claim 1, is characterized in that: described fluorescent material is gadolinium oxysulfide rare earth.
3. the optical imaging system of a kind of medical radionuclide as claimed in claim 1, is characterized in that: described fluorescent material is the mixture of gadolinium oxysulfide rare earth and viscosity crystal glue-dropping.
4. the optical imaging system of a kind of medical radionuclide as claimed in claim 3, is characterized in that: described system frame comprises base, is installed on the elevating lever on base, and be mounted on the object stage on described elevating lever.
5. the optical imaging system of a kind of medical radionuclide as claimed in claim 4, is characterized in that: described lucifuge passage is connected with described high-performance camera, and described lucifuge passage and described high-performance camera are on the same line.
6. the optical imaging system of a kind of medical radionuclide as claimed in claim 1, it is characterized in that: described lucifuge passage comprises main channel, sealing silica gel, camera fixed cap, described main channel comprises contact skin end and the camera installation end relative with described contact skin end, and described sealing silica gel is installed on described contact skin end, described camera fixed cap is installed on described camera installation end.
7. the optical imaging system of a kind of medical radionuclide as claimed in claim 6, it is characterized in that: described gamma-rays luminescent material coated plate is positioned over contact skin end, and described sealing silica gel can be fitted with human body skin, described camera fixed cap is fixed with high-performance camera.
8. use the optical imaging system of a kind of medical radionuclide of any one described in claim 1-7 to carry out a method for medical nucleic detection, it is characterized in that: it comprises the following steps,
Step 1: be coated with on gamma-rays luminescent material coated plate and excite the fluorescent material that can produce fluorescence signal by gamma-rays;
Step 2: lucifuge passage is closely leaned against the position to be detected that injection has the patient to be detected of diagnosis radioisotope labeling medicine;
Step 3: with high-performance collected by camera fluorescence signal.
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| CN106491094A (en) * | 2016-11-30 | 2017-03-15 | 西北大学 | A kind of medical radionuclide imaging system based on radiofluorescence material coated plate |
| CN107569210A (en) * | 2017-07-25 | 2018-01-12 | 西北大学 | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding |
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Application publication date: 20151104 |