CN109254310A - Detection device, the imaging system including the detection device and its detection method - Google Patents
Detection device, the imaging system including the detection device and its detection method Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 16
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/17—Circuit arrangements not adapted to a particular type of detector
- G01T1/178—Circuit arrangements not adapted to a particular type of detector for measuring specific activity in the presence of other radioactive substances, e.g. natural, in the air or in liquids such as rain water
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- High Energy & Nuclear Physics (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine (AREA)
- Measurement Of Radiation (AREA)
Abstract
The embodiment of the present application discloses detection device, the imaging system including the detection device and its detection method, the detection device includes: detector, for detecting the radioactive ray issued from target organism and generating corresponding electric signal in response to the radioactive ray；Fixed structure, surface corresponding to the target area for the detector to be fixed in the target organism；Processor, the electric signal for generating to the detector are handled the radioactive activity to determine the target area.By utilizing technical solution provided by the present application, cost can be reduced, reduces power consumption, improve data processing speed and provides new imaging evidence for scientific research and clinic.
Description
Technical field
This application involves radiation detection application field, in particular to a kind of detection device, the imaging including the detection device
System and its detection method.
Background technique
The description of this part only provides and discloses relevant background information to the application, without constituting the prior art.
Nuclear medicine is a kind of modern medicine image technology, by human body injection be marked with can generate γ photon or
The tracer of the radionuclide of positive electron, and tracer is known by ray caused by detectable radionuclide out of the human body
Agent is in the intracorporal distribution of people and change information, for the diagnosing and treating of disease.Nuclear medicine is typical molecule shadow
As means, it is able to reflect the intracorporal physiology of people, metabolism, function, molecular information, is one of current main-stream medical image means.
Medicine imaging technique mainly includes positron emission tomography (Positron Emission
Tomography, abbreviation PET) and single photon emission computerized tomography (Single Photon Emission Computed
Tomography, abbreviation SPECT) both technologies.Wherein, PET technology and SPECT technology are mainly that snoop tag has hair respectively
The drug of the radionuclide of positive electron and single photon is penetrated in the intracorporal distribution of people and change information.
It is examined in the prior art using the devices such as PET device or SPECT device to be detected to human body with aided disease
When disconnected, usually by the drug injection of radioisotope labeling to human body, human body then is surrounded using the detector in device, from
Different angle acquires optical signal caused by the intracorporal drug of people, optical signal collected is converted to electric signal and to telecommunications
Number carry out image reconstruction, so as to determine the intracorporal diseased region of people and lesion class according to obtained reconstruction image
Type.99mTc- diethyl antifebrin diglycinee (EHIDA) is carried out to baby for example, can use SPECT imaging device
Hepatobiliary dynamic imaging, whereby it can be detected that whether baby suffers from congenital biliary atresia.
Summary of the invention
During realizing the application, inventor has found that PET device and SPECT device in the prior art at least exist such as
Lower problem:
(1) there are the devices such as ray tube, scanning support, a large amount of detectors, this causes, and its higher cost, volume be larger, structure
Complexity, and its mobility and adjustability are poor；
(2) when being checked using above-mentioned apparatus human body, can not 24 hours real-time monitoring human body situations, and can not
The phase imaging of long period is carried out on demand；
(3) it is not suitable for fear of confined spaces due to the closure of above-mentioned apparatus, hyperactivity, orthopnea, can not lie down
Patient etc., to affect its scope of application；
(4) need to carry out image reconstruction after acquiring all signal to obtain the distributed in three dimensions image of inside of human body,
This makes the clinical data required time for obtaining having reference value from above-mentioned apparatus longer, can not make diagnosis in real time；
The purpose of the embodiment of the present application is to provide a kind of detection device, the system including the detection device, above-mentioned to solve
At least one problem.
To achieve the goals above, the embodiment of the present application provides a kind of detection device comprising:
Detector, for detecting the radioactive ray issued from target organism and being produced in response to the radioactive ray
Raw corresponding electric signal；
Fixed structure, table corresponding to the target area for the detector to be fixed in the target organism
Face；
Processor, the electric signal for generating to the detector are handled the radiation to determine the target area
Property activity.
Preferably, the detector includes:
Scintillation crystal, for receiving incident radioactive ray and generating corresponding optical signal；
Electrooptical device, the optical signal for generating the scintillation crystal are converted to electric signal；
Coupling layer, for coupling the scintillation crystal and the electrooptical device.
Preferably, the scintillation crystal is the crystal array or the continuous crystal of monolith being made of multiple crystal.
Preferably, the electrooptical device includes single-photon avalanche diode, photomultiplier tube and silicon photoelectric multiplier
One of or it is a variety of.
Preferably, the coupling layer is made of optics silicone grease or optical glass.
Preferably, the fixed structure includes applying and/or fixing glue, wherein the application coats the detector
Outer surface, and the application is equipped with the opening for exporting the electric signal that the detector generates；The fixed glue sticking
On the bottom of the detector.
Preferably, the detection device further include:
Collimator for collimating the incident direction of the radioactive ray, and makes the radioactive ray after collimation
Into the detector, the collimator is arranged between the detector and the fixed structure and passes through the fixed knot
Structure and be fixed on surface corresponding to the target area.
Preferably, the collimator includes one or more collimation layers, and each collimation layer is equipped with one or more through-holes,
And when the collimator includes multiple collimation layers, at least there are two be dislocation coupling between collimation layer.
Preferably, the length of the collimator can be adjusted according to the position of the target area.
Preferably, the detection device further include:
First wrapping layer is set to around the scintillation crystal.
Preferably, first wrapping layer includes with one of flowering structure: by barium sulfate, tinfoil and shading rubber belt group
At three-decker, be made of barium sulfate and tinfoil double-layer structure, be made of Teflon single layer structure, by Teflon and screening
The double-layer structure of optical cement band composition or the double-layer structure being made of Teflon and tinfoil, wherein the barium sulfate or the spy
Fluorine dragon is located at the innermost layer of first wrapping layer and is attached at the outer surface of the scintillation crystal, and the shading rubber belt is located at
The outermost layer of first wrapping layer.
Preferably, the detection device further include:
Transmission structure, electric signal transmission for generating the detector to the processor, and it includes wired
Transmission module and/or wireless transport module.
The embodiment of the present application also provides a kind of imaging systems comprising: above-mentioned detection device and equipment for reconstructing image,
Described image reconstructing device be used for electric signal caused by the detector in the detection device carry out image reconstruction with
Obtain the distributed image of the target area in the target organism body.
Preferably, the imaging system further include:
Auxiliary device is used cooperatively together with the detection device, and including gammacamera, plate PET, plate
One of SPECT, PET complete machine and SPECT complete machine are a variety of.
The embodiment of the present application also provides a kind of method that above-mentioned detection device detects organism, the method packets
It includes:
Step S1: detector is fixed on appearance corresponding to the target area in target organism using fixed structure
Face；
Step S2: the radioactive ray issued from the target organism is detected using the detector and is generated corresponding
Electric signal；
Step S3: electric signal caused by the detector is handled using processor to determine the target area
The radioactive activity in domain.
Preferably, before step S1, the method also includes:
Step S0 determines the target area in the target organism using the detector and the processor.
Preferably, before step S2, the method also includes:
The radioactive ray issued from the target organism is collimated using collimator, and is made after collimating
The radioactive ray enters the detector.
As can be seen from the technical scheme provided by the above embodiments of the present application, the embodiment of the present application using fixed structure by that will be visited
It surveys device and is fixed on surface corresponding to the target area in organism, without scanning support and ray tube, and detector number
PET the or SPECT device of amount compared to the prior art significantly reduces, this may be implemented to reduce volume, reduces cost and simplification
The purpose of structure, and the mobility and adjustability of detection device can be improved.Moreover, it is also possible to improve the use of detection device
Convenience, and the phase imaging of long period with 24 hours real-time monitoring biological conditions, can be carried out on demand, it can also fit
For fear of confined spaces, hyperactivity, orthopnea, the patient that can not be lieed down, this improves its scope of application.
Detailed description of the invention
In order to illustrate the technical solutions in the embodiments of the present application or in the prior art more clearly, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The some embodiments recorded in application, for those of ordinary skill in the art, in the premise of not making the creative labor property
Under, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is that a kind of 3 D stereo of detection device provided by the embodiments of the present application splits the schematic diagram of structure；
Fig. 2 is the cross-sectional view of the detection device in Fig. 1；
Fig. 3 shows detector in the schematic diagram of the skin surface of human body；
Fig. 4 shows detector in the schematic diagram of the body cavity surface of human body；
Fig. 5 is the schematic diagram of animal experimental model；
Fig. 6 m- radioactive activity curve when showing corresponding to the animal experimental model in Fig. 5；
Fig. 7 is the schematic diagram of two collimation layers of dislocation coupling；
Fig. 8 is a kind of structural representation of system including the detection device in Fig. 1 and Fig. 2 provided by the embodiments of the present application
Figure；
Fig. 9 is that a kind of detection device using in Fig. 1 and Fig. 2 provided by the embodiments of the present application detects organism
The flow diagram of method.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present application, technical solutions in the embodiments of the present application carries out clear, complete
Site preparation description, it is clear that described embodiment is only used for illustrating a part of the embodiment of the application, rather than all
Embodiment, it is undesirable that limitation scope of the present application or claims.Based on the embodiment in the application, this field is common
The application guarantor all should belong in technical staff's all other embodiment obtained without making creative work
The range of shield.
It should be noted that it can be arranged directly on another when element is referred to as on " setting exists " another element
On element or there may also be elements placed in the middle.When element is referred to as " connection/coupling " to another element, it be can be directly
Another element is connect/be coupled in succession or may be simultaneously present centering elements.Term as used herein " connection/coupling " can
To include electrical and/or mechanical-physical connection/coupling.Term as used herein "comprises/comprising" refers to feature, step or element
Presence, but the presence or addition of one or more other features, step or element is not precluded.Term as used herein
"and/or" includes any and all combinations of one or more related listed items.
Unless otherwise defined, all technical and scientific terms used herein and the technical field for belonging to the application
The normally understood meaning of technical staff is identical.Term used herein is intended merely to the purpose of description specific embodiment, and
It is not intended to limitation the application.
In addition, term " first ", " second " etc. are used for description purposes only the life similar with distinguishing in the description of the present application
Object between the two and is not present sequencing, can not be interpreted as indication or suggestion relative importance.In addition, the application's
In description, unless otherwise indicated, the meaning of " plurality " is two or more.
In embodiments herein, radioactive ray can refer to X-ray, gamma-rays, β ray and/or alpha ray etc..
Target organism can be the organism that pointed injection has radiopharmaceutical (being marked with radionuclide thereon), for example, people or dynamic
Object is also possible to other objects for needing to detect.Target area can refer to inside organism occur abnormal organ (for example,
Heart, enteron aisle, stomach etc.) region, it is also possible to the other area-of-interests for needing to detect in target organism.Target area
Surface corresponding to domain can refer to the skin surface or body cavity surface of organism.Electric signal can refer to electric impulse signal, connect
Continuous electric signal or discrete electric signals etc..
System and its spy to detection device provided by the embodiment of the present application, including the detection device with reference to the accompanying drawing
Survey method is described in detail.
As depicted in figs. 1 and 2, the embodiment of the present application provides a kind of detection device 100, may include:
Detector 110, for detecting the radioactive ray issued from target organism and being produced in response to radioactive ray
Raw corresponding electric signal；
Fixed structure 120, for detector 110 to be fixed on surface corresponding to the target area in target organism；
Processor 130, the electric signal for generating to detector 110 are handled, to determine the radiation of target area
Property activity.
In embodiments herein, detector 110 may include scintillation crystal 111, the coupling set gradually from top to bottom
Close layer 112 and electrooptical device 113.Scintillation crystal 111 can be used for receiving incident radioactive ray and light occurring
Generated after the effects such as electrical effect, Compton effect, Rayleigh scattering and/or pair effect corresponding optical signal (such as, it is seen that
Light photon).Scintillation crystal 111 may include yttrium luetcium silicate (LYSO) crystal, silicic acid lutetium (LSO) crystal, bismuth germanium oxide (BGO) crystalline substance
Body, barium fluoride (BaF2) crystal, lanthanum bromide (LaBr3) crystal, yttrium aluminate (YAP) crystal, aluminic acid lutetium (LuAP) crystal, sodium iodide
(NaI) one of inorganic scintillation crystals such as crystal, cesium iodide (CsI) crystal or a variety of.Scintillation crystal 111 can be to be cut completely
It cuts or crystal permutation that multiple crystal for not exclusively cutting are constituted, is also possible to the continuous crystal of monolith.The axial direction of scintillation crystal 111
Can be vertical with the surface corresponding to target area, and in detection, it can be contacted with the surface.Coupling layer 112 can be with
For coupled scintillation crystal 111 and electrooptical device 113, scintillation crystal 111 and electrooptical device 113 are coupled with realizing
Together.Coupling layer 112 can be thickened by silicone oil made of paste (for example, optics silicone grease) form, be also possible to by
Optical glass composition, can also be other guide structures.What electrooptical device 113 can be used for generating scintillation crystal 111
Optical signal is converted to electric signal, can be one in single-photon avalanche diode, photomultiplier tube and silicon photoelectric multiplier etc.
Kind is a variety of, is also possible to other devices with photomultiplication effect.
It should be noted that, although illustrating only a detector 110 in attached drawing, but actually the detection device can wrap
Multiple detectors 110 are included, it is not restricted to the quantity of detector 110 herein.
It is fixed after determining the target area in target organism in actual operation in embodiments herein
Surface corresponding to the target area that structure 120 can be used for being fixed on detector 110 in target organism is (for example, skin
Surface or body cavity surface) at, as shown in Figure 3 and Figure 4.Fixed structure 120 can be detachably connected with detector 110, and can
To be any structure for not influencing radioactive ray and penetrating and there is fixed function, such as it can be application 121, but be not limited to
This.Application 121 can coat the outer surface (outer surface that specifically, can refer to electrooptical device 113) of detector 110,
And the periphery of its surrounding or partial region and surface corresponding to target area or the surface directly fits, so as to protect
Detector 110 is fixed on surface corresponding to the target area in target organism by card.In addition, can be equipped in application 121
For the opening of detector 110 (specifically, electrooptical device 113) output electric signal, transmitted produced by detector 110 outward
Electric signal.
In addition, fixed structure 120 can also include fixed glue (for example, glue) 122, detector 110 can be bonded in
Bottom (specifically, can refer to the bottom of scintillation crystal 111, the i.e. side opposite with electrooptical device 113) on,
Detector 110 can be fixed on surface corresponding to the target area in target organism, it is brilliant to can be also used for filling flashing
Gap between body 111 and the skin surface of target organism.When fixed structure 120 includes application 121 and fixed glue 122,
The fixed effect of detector 110 can be made more preferable.
In embodiments herein, processor 130 can be connect with the electrooptical device 113 in detector 110, from
And the electric signal that can be exported to electrooptical device 113 is handled.Specifically, processor 130 can recorde the unit time
The quantity of the electric signal that interior electrooptical device 113 exports determines in target organism so as to (1) according to the following formula
Target area radioactive activity:
Ci=k*Counts (1)
Wherein, Ci indicates radioactive activity；Counts indicates the electric signal quantity in the unit time；K is fixed parameter
Value.
Furthermore, it is possible to be ordinate using the time as abscissa, electric signal quantity, when drafting m- radioactive activity curve, such as
Shown in Fig. 6, Fig. 6 m- radioactive activity curve when showing corresponding to the animal experimental model in Fig. 5.According to determining
Radioactive activity or the when m- radioactive activity curve drawn, can determine the metabolic rule of target area, from
And may determine that target area whether lesion.It is living by the radioactivity determined according to the electric signal of the detector of different location
Degree, can go out lesion locations and/or disease type etc. with comprehensive descision.For example, being the situation of human body intestinal canal for target area, just
Radioactive activity starts to occur in about 15min in normal situation, and radioactive activity reaches peak value and enters entire lowering rank in 1 hour
Section.If m- radioactive activity curve shows that radioactive activity does not reach in 1 hour when obtained after the processing of processor 130
To peak value, then illustrate that the patient may be with obstruction of biliary tract, and the time of peak value can be reached according to radioactive activity come really
Determine obstruction of biliary tract degree.For another example being the situation of human heart for target area, if processor 130 is acquired after handling
When m- radioactive activity curve show that radioactive activity is not up to peak value even radioactivity missing in preset time, then says
The bright patient may suffer from myocardial infarction, and can reach the time of peak value according to radioactive activity to determine the serious journey of infarct
Degree.
In another embodiment of the application, before the quantity for the electric signal that record electrooptical device 113 exports, place
Reason device 130 can also amplify electric signal, integrate, the processing such as analog-to-digital conversion, to convert electrical signals to digital signal, from
And it is handled convenient for follow-up data.
It should be noted that processor 130 can be the processor in computer, it is also possible to entire computer, may be used also
Equipment is calculated with others.
In another embodiment of the application, which can also include that the standard of setting is matched with detector 110
Straight device 140, can be used for collimating the radioactive ray issued from target organism, and penetrate the radioactivity after collimation
Line enters detector 110, this can guarantee the received radioactive ray of detector 110 from its pair linear position, from
And can to avoid around target organism and in vivo other signals bring interference, being directed to for subsequent probe result can be improved in this
Property, and then the accuracy of follow-up diagnosis result can be improved.
Collimator 140 can be set between detector 110 and solid structure 120, and it is brilliant to be particularly provided at flashing
It, can be perpendicular to surface corresponding to the target area between body 111 and application 121, and preferably.Moreover, collimation
Device 140 can be fixed on corresponding to the target area in target organism together by fixed structure 120 and detector 110
Surface.It can be fixed, can also relatively move between collimator 140 and detector 110.Moreover, collimator 140 can be down to
Two sides of scintillation crystal 111 and opposite with receiving plane (that is, the surface of photon being received, for example, bottom surface) are coated less
Another surface, and coupling layer 112 and photoelectric conversion crystal 113 can also be coated.In addition, not wrapped in fixed structure 120
When including fixed glue 122, scintillation crystal 111 in detector 110 can be corresponding to the bottom end of collimator 140 and target area
Surface directly contact；When fixed structure 120 includes fixed glue 122, the scintillation crystal 111 in detector 110 can pass through
Fixed glue 122 and the surface mediate contact corresponding to the bottom end of collimator 140 and target area.
When fixed structure includes application 121, can be equipped with and the opening pair in application 121 on the top of collimator 140
The opening answered can electric signal caused by output detector 110 outward by the opening.
Collimator 140 may include one or more collimation layers, and each collimation layer is equipped with one or more through-holes, each
Scintillation crystal 111 in the direction directed towards detector 110 of through-hole, and through-hole can be the shapes such as circle, triangle, polygon
Shape.In addition, being dislocation coupling between wherein at least two collimation layer, and collimate layer when the collimation layer is multiple
Position be it is adjustable, so as to improve the performance of collimator 140 and can satisfy different application demands.The mistake
Position coupling can refer to that the center line of through-hole of two collimation layers both in series coupled is not overlapped, as shown in Figure 7.
Collimator 140 can be made of radiation proof materials such as lead after wolfram steel or package.By collimator 140, can keep away
Exempt from the interference of other rays around target organism, so as to further increase the accuracy of subsequent probe result, Jin Eryou
Conducive to the medical diagnosis on disease to organism.
In addition, the length of collimator 140 can be adjusted according to the position of target area, so as to flexibly make
With.For example, the length of collimator 140 is longer, if the target area is part cardiac muscle to shield around target organism
And other internal all signals；If the target area is entire enteron aisle, the length of collimator 140 can be significantly less than mesh
Length when region is part cardiac muscle is marked, to improve the experience effect of patient.
It is located between detector 110 and application 121 it should be noted that, although illustrating only collimator 140 in figure, but real
Collimator 140 can also be between detector 110 and solid gum 122 on border.
In another embodiment of the application, which can also include the first wrapping layer 150, can set
It is placed in around scintillation crystal 111, to reflect the light photon generated inside scintillation crystal 111, protects scintillation crystal 111 not
It is influenced by extraneous visible light signal, and can be Nian Jie to realize the fixation to scintillation crystal 111 with fixed glue 122.First
Wrapping layer 150 can be single or multi-layer structure, to improve the protecting effect to scintillation crystal 111.For example, wrapping layer 150 can
With the three-decker being made of barium sulfate, tinfoil and shading rubber belt etc., the double-layer structure being made of barium sulfate and tinfoil etc.,
The single layer structure that is made of Teflon, the double-layer structure being made of Teflon and shading rubber belt etc. or by Teflon and tinfoil
The double-layer structure of equal compositions, wherein barium sulfate and Teflon can be located at the innermost layer of the first wrapping layer 150, and be attached at
The outer surface of scintillation crystal 111；Tinfoil can be located at the middle layer of the first wrapping layer 150, and can be used for wrapping up barium sulfate
And Teflon；Shading rubber belt can be located at the outermost layer of the first wrapping layer 150.
In another embodiment of the application, which can also include transmission structure 160, with detector
110 and processor 130 connect, can be used for electric signal transmission caused by the electrooptical device 113 in detector 110
To processor 130.The transmission structure may include wire transmission module and/or wireless transport module, wherein wire transmission mould
Block can be data line or cable etc., and the wireless transport module can pass through wireless routing, WiFi agreement, purple honeybee
(Zigbee) modes such as agreement are by electric signal transmission to processor 130 to carry out subsequent processing.It, can be with by transmission structure 160
Electric signal caused by detector 110 is transmitted, neatly so as to meet different application demands.
In another embodiment of the application, which can also include memory (not shown), can
To connect with processor 130, with the obtained data processed result of storage processor 130, and it can also be with detector 110
In electrooptical device 113 connect, to store electric signal caused by electrooptical device 113.
In another embodiment of the application, which can also include the second wrapping layer (not shown),
It can be used for the encapsulated by structures such as detector 110 and collimator 140 wherein, in order to be fixed in body cavity surface.Institute
It states the second wrapping layer and can be penetrated by not influencing radioactive ray and the intracorporal material of biology can be placed in and form.
By above description as can be seen that detection device provided by the embodiments of the present application using fixed structure by that will be detected
Device is fixed on surface corresponding to the target area in organism, without scanning support and ray tube, and detector quantity
PET or SPECT device compared to the prior art significantly reduces, this may be implemented to reduce volume, reduce cost and simplify knot
The purpose of structure, and the mobility and adjustability of detection device can be improved.Moreover, because detector is fixed on organism,
Without scanning support, it is possible to be monitored whenever and wherever possible to organism, the easy-to-use of detection device can be improved in this
Property, and the phase imaging of long period with 24 hours real-time monitoring biological conditions, can be carried out on demand, it can be applicable to
Fear of confined spaces, hyperactivity, the patient that can not be lieed down, this improves its scope of application.In addition, detector generate electric signal it
Afterwards, can electric signal in the fast recording unit time quantity to determine the radioactive activity of target area, without into
Row subsequent image reconstruction, this can reduce power consumption and improve data processing speed.
The embodiment of the present application also provides a kind of system including detection device 100 described in above-described embodiment, such as Fig. 8
It is shown.The system can also include equipment for reconstructing image 200, and equipment for reconstructing image 200 can turn with the photoelectricity in detector 110
Parallel operation part 113 and/or processor 130 connect, and can be used for electricity caused by the detector 110 in detection device 100
Signal carries out image reconstruction to obtain the distributed image of the target area in target organism body.According to the distributed image, Ke Yigeng
Be conducive to determine the metabolic rule of bioagent in order to subsequent scientific research, doctor can also be conducive to and intuitively diagnose birth
The intracorporal diseased region of object and its type, so as to symptomatic treatment.
It should be noted that equipment for reconstructing image 200 can be integrated in one or be independently arranged with processor 130.
In addition, the system also can also include auxiliary device (not shown) in another embodiment of the application,
It can be used cooperatively together with detection device 100.For different organisms, the different parts of same organism and organism
The present situation, can choose using detection device 110 and/or auxiliary device, so as to further guarantee subsequent analysis
Or the accuracy of diagnostic result.The auxiliary device can be gammacamera in the prior art, plate PET, plate SPECT, PET
Complete machine or SPECT complete machine.
The embodiment of the present application also provides a kind of method detected using above-mentioned detection device to organism, such as Fig. 9
Shown, this method may comprise steps of:
Step S1: detector is fixed on surface corresponding to the target area in target organism using fixed structure.
After predefining the target area in target organism, it can use fixed structure and be fixed on detector
Skin surface corresponding to target area in target organism or body cavity surface.
Step S2: the radioactive ray issued from target organism is detected using detector and generates corresponding electric signal.
After detector is fixed on target organism, detector can use to detect from target organism sending
Radioactive ray.After detecting radioactive ray, detector can generate corresponding electric signal.
Step S3: radiation to determine target area is handled using processor electric signal caused by detector
Property activity.
After detector generates electric signal, it can use in processor record unit time caused by detector 110
Then the quantity of electric signal calculates the radioactive activity of target area according to above-mentioned formula (1).Furthermore, it is possible to be with the time
Abscissa, electric signal quantity are ordinate, when drafting m- radioactive activity curve.According to identified radioactive activity or
The when m- radioactive activity curve drawn, can determine the metabolic rule, diseased region and/or disease class of bioagent
Type etc..
In another embodiment of the application, before step S1, this method can also include:
Step S0: the target area in target organism is determined using detector and processor；
It, can be according to doctor to target organism when thering is the target organism of radiopharmaceutical to detect injection
Tentative diagnosis result or the empirical data counted before primarily determine the region to be detected in target organism, then basis
Region to be detected simultaneously determines target area using detector and processor.Specifically,
Place the detector skin surface corresponding to region to be detected or body cavity surface, then using detector detection from
The interior radioactive ray issued of organism simultaneously generates corresponding electric signal and moves left and right detector in areas adjacent to be detected,
Electric signal caused by detector is handled using processor, corresponding position when determining radioactive activity maximum
It sets, so that the position is determined as target area.
The movement of the detector can be controlled by people or controller.The target area can refer to inside organism
There is abnormal organ (for example, heart, enteron aisle, stomach etc.) region, is also possible to need to detect in target organism
Other regions.
In another embodiment in this application, before step S0 or S2, this method can also include:
Step S4: collimating the radioactive ray issued from target organism using collimator, and makes after collimating
Radioactive ray enters detector.
Before the radioactive ray using detector detection target organism, collimator can use to penetrate to radioactivity
Line is collimated, then using the radioactive ray after detector detection collimation, to avoid around target organism and its in vivo
The interference of other signals bring.
About the detailed description of above-mentioned steps S0-S4, it is referred to the above-mentioned description to detection device, it is no longer superfluous herein
It chats.
It can be seen from the above description that the embodiment of the present application is raw by the way that detector is fixed on target using fixed structure
Surface corresponding to target area in object, and the ray issued from target organism and utilization are detected using detector
Processor records the quantity of electric signal caused by detector to determine the radioactive activity of target area, without carrying out
Image reconstruction, this can reduce power consumption and improve data processing speed.
System, device, unit, module that above-described embodiment illustrates etc., specifically can be real by computer chip and/or entity
It is existing, or realized by the product with certain function.For convenience of description, it describes to be divided into when apparatus above with function various
Device describes respectively.Certainly, when implementing the application can the function of each device same or multiple computer chips and/
Or it is realized in entity.
Although this application provides the method operating procedure as described in above-described embodiment or flow chart, based on conventional or
It in the method may include more or less operating procedure without creative labor.There is no must in logicality
In the step of wanting causality, the execution of these steps sequence is not limited to provided by the embodiments of the present application execute sequence.
All the embodiments in this specification are described in a progressive manner, same and similar portion between each embodiment
Dividing may refer to each other, and the highlights of each of the examples are differences from other embodiments.
Above-described embodiment be for convenient for those skilled in the art it will be appreciated that and being described using the application
's.Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein
General Principle is applied in other embodiments without having to go through creative labor.Therefore, the application is not limited to the above embodiments,
Those skilled in the art do not depart from improvement that the application scope is made and modification all should be in this Shens according to the announcement of the application
Within protection scope please.
Claims (17)
1. a kind of detection device, which is characterized in that the detection device includes:
Detector, for detecting the radioactive ray issued from target organism and generating in response to the radioactive ray pair
The electric signal answered；
Fixed structure, surface corresponding to the target area for the detector to be fixed in the target organism；
Processor, the electric signal for generating to the detector are handled to determine that the radioactivity of the target area is living
Degree.
2. detection device according to claim 1, which is characterized in that the detector includes:
Scintillation crystal, for receiving incident radioactive ray and generating corresponding optical signal；
Electrooptical device, the optical signal for generating the scintillation crystal are converted to electric signal；
Coupling layer, for coupling the scintillation crystal and the electrooptical device.
3. detection device according to claim 2, which is characterized in that the scintillation crystal is the crystalline substance being made of multiple crystal
Volume array or the continuous crystal of monolith.
4. detection device according to claim 2, which is characterized in that the electrooptical device includes single-photon avalanche two
One of pole pipe, photomultiplier tube and silicon photoelectric multiplier are a variety of.
5. detection device according to claim 2, which is characterized in that the coupling layer is by optics silicone grease or optical glass group
At.
6. detection device according to claim 1, which is characterized in that the fixed structure includes applying and/or fixing glue,
Wherein, the application coats the outer surface of the detector, and the application is equipped with and generates for exporting the detector
Electric signal opening；The fixed glue sticking is on the bottom of the detector.
7. detection device according to claim 1, which is characterized in that the detection device further include:
Collimator for collimating the incident direction of the radioactive ray, and enters the radioactive ray after collimation
The detector, the collimator are arranged between the detector and the fixed structure and pass through the fixed structure
It is fixed on surface corresponding to the target area.
8. detection device according to claim 7, which is characterized in that the collimator includes one or more collimation layers,
Each collimation layer is equipped with one or more through-holes, and when the collimator includes multiple collimation layers, at least there are two quasi-
It is dislocation coupling between straight layer.
9. detection device according to claim 7, which is characterized in that the length of the collimator is according to the target area
Position adjust.
10. detection device according to claim 2, which is characterized in that the detection device further include:
First wrapping layer is set to around the scintillation crystal.
11. detection device according to claim 10, which is characterized in that first wrapping layer includes in flowering structure
It is a kind of: the three-decker that is made of barium sulfate, tinfoil and shading rubber belt, the double-layer structure being made of barium sulfate and tinfoil, by
It the single layer structure of Teflon composition, the double-layer structure that is made of Teflon and shading rubber belt or is made of Teflon and tinfoil
Double-layer structure, wherein the barium sulfate or the Teflon are located at the innermost layer of first wrapping layer and are attached at institute
The outer surface of scintillation crystal is stated, for the tinfoil for wrapping up the barium sulfate or the Teflon, the shading rubber belt is located at institute
State the outermost layer of the first wrapping layer.
12. detection device according to claim 1, which is characterized in that the detection device further include:
Transmission structure, electric signal transmission for generating the detector to the processor, and it includes wire transmission
Module and/or wireless transport module.
13. a kind of imaging system characterized by comprising detection device of any of claims 1-12 and figure
As reconstructing device, described image reconstructing device is used to carry out electric signal caused by the detector in the detection device
Image reconstruction is to obtain the distributed image of the target area in the target organism body.
14. imaging system according to claim 13, which is characterized in that the imaging system further include:
Auxiliary device is used cooperatively together with the detection device, and including gammacamera, plate PET, plate SPECT,
One of PET complete machine and SPECT complete machine are a variety of.
15. a kind of method detected using the detection device of any of claims 1-12 to organism, special
Sign is, which comprises
Step S1: detector is fixed on surface corresponding to the target area in target organism using fixed structure；
Step S2: the radioactive ray issued from the target organism is detected using the detector and generates corresponding telecommunications
Number；
Step S3: electric signal caused by the detector is handled using processor to determine the target area
Radioactive activity.
16. according to the method for claim 15, which is characterized in that before step S1, the method also includes:
Step S0 determines the target area in the target organism using the detector and the processor.
17. method according to claim 15 or 16, which is characterized in that before step S2, the method also includes:
The radioactive ray issued from the target organism is collimated using collimator, and is made described after collimation
Radioactive ray enters the detector.
Priority Applications (2)
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| CN201811218238.6A CN109254310A (en) | 2018-10-17 | 2018-10-17 | Detection device, the imaging system including the detection device and its detection method |
| PCT/CN2019/090910 WO2020078013A1 (en) | 2018-10-17 | 2019-06-12 | Detection device, imaging system comprising same, and detection method thereof |
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