CN105105697B - A kind of medical spy radioluminescence imaging system and its imaging method - Google Patents
A kind of medical spy radioluminescence imaging system and its imaging method Download PDFInfo
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- CN105105697B CN105105697B CN201510386451.8A CN201510386451A CN105105697B CN 105105697 B CN105105697 B CN 105105697B CN 201510386451 A CN201510386451 A CN 201510386451A CN 105105697 B CN105105697 B CN 105105697B
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- endoscope
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Abstract
The present invention discloses a kind of medical spy radioluminescence imaging system and its imaging method, and its imaging system includes camera bellows, intensifying screen, endoscope, CCD camera and computer；Intensifying screen is located in camera bellows with endoscope, and the two is of coupled connections, and endoscope is connected with the CCD camera outside camera bellows, and CCD camera is with calculating mechatronics；Intensifying screen is to be detachably connected with endoscope.Its imaging method is：When intensifying screen is not installed, endoscope collection white light, CCD camera optical imagery obtains white light figure；When intensifying screen is installed, the γ converting photons that nucleic is launched are fluorescence signal by intensifying screen, and endoscope collection fluorescence signal, CCD camera carries out fluorescence imaging, obtains fluorogram；Image procossing fusion is carried out to white light figure and fluorogram and obtains registering figure.The imaging system of the present invention, its signal is strong, signal penetrability is strong, image taking speed is fast, it is simple to operate, small to the physical effects of patient, can at utmost reduce the resisting psychology of patient.
Description
Technical field
The present invention relates to biological medicine molecular image technical field, more particularly to a kind of medical spy radioluminescence imaging
System and its imaging method.
Background technology
Endoscopy refers to be sent into detecting instrument in vivo, then to internal deep layer disease by human body natural's cavity by vitro
Technology of the disease through row detection, is that the optical signalling tissue penetration limitation that the clinical Transformation Application of optical molecular image technology faces is asked
Topic provides effective solution.Using endoscope it can be seen that the lesion that X-ray can not be shown, thus it to doctor very
It is useful.
And the imaging technique of endoscope carries out accurately diagnosis to the state of an illness to doctor and plays vital effect.
Radionuclide imaging is one kind in imaging technique, and radionuclide imaging has the deficiency that instrument is expensive, imaging is slow.Cherenkov into
As (nucleic-optical imagery) is a kind of new imaging method, such as Application No. CN201310261548.7 patent document public affairs
Open " a kind of medical through endoscope Cherenkov fluoroscopic imaging systems ", it is characterised in that it includes：Endoscope probe 01, is used
That the Cherenkov that sends is combined with probe is glimmering for targeting target inside collection detected object surface white light signal and/or detected object
Optical signal；Optical fiber image transmission beam 02, one end is connected with the endoscope probe 01, for transmitting the white light signal and/or described
Cherenkov's fluorescence signal；Detection device 03, is connected with the other end of the optical fiber image transmission beam 02, for being passed described through optical fiber
The white light signal and/or Cherenkov's fluorescence signal that video beam 02 is transmitted are converted into electric signal；Calculate with imaging device 04, it is and described
Detection device 03 is connected, and for carrying out subsequent treatment to the electric signal after the conversion, obtains the white light knot on detected object surface
Targeting target is combined the Cherenkov's fluorogram sent with probe inside composition picture and/or detected object.It uses nucleic-optics
It is imaged (Cherenkov's imaging strategies), shortcoming is：Be imaged nucleic it is few, image taking speed is slow, light signal strength is low, signal penetrability not
The shortcoming of foot.And in nucleic-optical imagery reinforcing element in signal enhancing strategy (mainly nano particle etc.) bio-safety
Property is poor.
Radioluminescence imaging can lower the imaging time of radio nuclide imaging significantly, while overcoming conventional nucleic-optical imagery (to cut
Lun Kefu imaging strategies) imaging nucleic is few, image taking speed is slow, light signal strength is low, signal penetrability is not enough shortcoming, can be with
Overcome the biological safety bottle of reinforcing element in conventional nucleic-optical imagery signal enhancing strategy (mainly nano particle etc.)
Neck, new developing method is provided for clinic.
Radioactive ray can excite enhanced sensitivity sense screen to light, and this is confirmed by preliminary experiment.Medical intensifying screen is that clinical radiation line is taken the photograph
The indispensable important equipment of shadow, it matches with X-ray film and used, and can be transformed into the radioactive ray for penetrating body makes film
Photosensitive visible ray, improves utilization ratio of the radioactive ray to light reaching the film.After measured, the optical density image formed on radiotelegram
In 95% above is radioactive ray can be converted into after visible fluorescence luminous energy to light reaching the film institute by the fluorescent material on intensifying screen
Cause, and the optical density image only less than 5% is formed by radioactive ray direct exposure.Therefore, the use of intensifying screen not only pole
The radiation damage of radioactive ray is reduced greatly, and has further expanded the detection methods and application of radiography.
Therefore, if intensifying screen can be applied in radioluminescence imaging, medical Endoscopy would is that one it is huge
Progressive, it will be solved, and optical signal in conventional imaging technique is poor, the shortcoming that signal penetrability is poor, image taking speed is slow, and sensitizing
Radioactive ray directly can be converted into fluorescence luminous energy by screen, internal without detecting instrument is sent into by human body natural's cavity, will be most
Big degree reduces the resisting psychology of patient.
The content of the invention
For above-mentioned the deficiencies in the prior art, the invention provides a kind of signal is strong, signal penetrability is strong, image taking speed
Hurry up, it is simple to operate, small to the physical effects of patient, and can at utmost reduce the medical spy radiation of the resisting psychology of patient
Luminescence imaging system and its imaging method.
To solve technical problem present in above-mentioned prior art, the concrete technical scheme of use is：
A kind of medical spy radioluminescence imaging system is included with lower component,
Camera bellows, it is used to accommodate Cherenkov's fluorescence detection device and object under test；
Intensifying screen, at the morbidity of object under test, the γ photons for gathering nucleic transmitting, and be by γ converting photons
Fluorescence signal；
Endoscope, it is used to gather fluorescence signal, and the lossless maximization of fluorescence signal is transferred into CCD camera；
CCD camera, it handles the fluorescence signal being collected into, and carries out optical imagery；Meanwhile, by the data and figure after processing
As exporting to computer；
Computer, it is used for the fusion treatment to data and image；
The endoscope and intensifying screen are in the camera bellows, and the dismountable company of coupling of one end and intensifying screen of endoscope
Connect, the other end of endoscope is connected with the CCD camera outside the camera bellows by optical fiber, the CCD camera and computer
Electrical connection.
The intensifying screen is cylindrical green-series rare earth intensifying screen.
Gadolinium oxysulfide is included in the composition of the intensifying screen.
The endoscope is medical fibre endoscope.
The pixel reading speed of the CCD camera be 30MHz, the CCD camera can collecting work temperature, the time for exposure,
Aperture size, frame frequency and EM gains.
Another object of the present invention is to provide a kind of imaging method of medical spy radioluminescence imaging system, and it includes
Following steps：
S1, object under test is directed at by endoscope, gathers white light；
S2, the white light that CCD camera is gathered according to endoscope carries out optical imagery, obtains white light figure；
S3, installs intensifying screen, and intensifying screen is aligned into object under test, the γ light that intensifying screen launches nucleic before endoscope
Son is converted into fluorescence signal；
S4, endoscope collection fluorescence signal；
S5, the fluorescence signal that endoscope is collected is transferred to CCD camera through optical fiber, and CCD camera carries out fluorescence imaging, obtained
Nucleic fluorogram；
White light figure obtained by step S2 and step S5 and nucleic fluorogram are carried out image procossing and matched somebody with somebody by S6, computer
Quasi- figure；
S7, is exported the registration figure using computer.
The detailed process of image procossing is as follows in the step S6：
S01, selects nucleic fluorogram, and carries out denoising, background subtraction value plus pseudo-colours, obtains the figure with valid data
As I1；
S02, area-of-interest is extracted from white light figure, obtains image I3；
S03, useful signal region is found in image I1 and obtains image I2；
S04, image I2 fusions are added on image I3, registering figure is obtained.
Described image I3 is to be based on each image significance and relative position in white light figure, color combining and textural characteristics, is adopted
Gained is extracted with region-growing method.
By using such scheme, a kind of medical spy radioluminescence imaging system of the present invention and its imaging method are with showing
There is technology to compare, it has technical effect that：
(1) by the way of intensifying screen, endoscope, CCD camera are sequentially connected, optical imaging apparatus detection nucleic, signal
By force, signal penetrability is strong, and image taking speed is fast.
(2) use the intensifying screen on endoscope head design, endoscope to be detachably connected with endoscope, operate simpler
Just；And the scattering influence of radioluminescence imaging can be reduced.
(3) exterior design is used completely, without there is detection device to stretch into inside of human body, to the physical effects very little of patient,
Principle of Pain sense, can at utmost reduce the resisting psychology of patient.
Brief description of the drawings
Fig. 1 is a kind of medical structural representation through endoscope Cherenkov's fluoroscopic imaging systems of prior art；
Fig. 2 is a kind of structural representation of medical spy radioluminescence imaging system of the present invention；
Fig. 3 is the connection signal of intensifying screen and endoscope in a kind of medical spy radioluminescence imaging system of the present invention
Figure；
Fig. 4 is a kind of structural representation of the imaging method of medical spy radioluminescence imaging system of the present invention；
Fig. 5 is a kind of Irnaging procedures schematic diagram of the imaging method of medical spy radioluminescence imaging system of the present invention.
Embodiment
To make the object, technical solutions and advantages of the present invention of greater clarity, with reference to instantiation, to the present invention
It is further described.It should be understood that these descriptions are merely illustrative, and it is not intended to limit the scope of the present invention.In addition,
In illustrating below, the description to known features and technology is eliminated, to avoid unnecessarily obscuring idea of the invention.
As shown in Figures 2 to 5,
A kind of medical spy radioluminescence imaging system, including camera bellows 1, intensifying screen 2, endoscope 3, CCD camera 4 and meter
Calculation machine 5；One end of the intensifying screen 2 and the endoscope 3 is of coupled connections, and the intensifying screen 2 and endoscope 3 are located at camera bellows 1
Interior, the other end of the endoscope 3 is connected with the CCD camera 4 outside the camera bellows 1 by optical fiber, the CCD camera 4
Interior to be provided with optical imagery module, the CCD camera 4 is electrically connected with computer 5；The intensifying screen 2 is detachably to connect with endoscope 3
Connect.Adapter 6 is connected between the endoscope 3 and CCD camera 4.
The camera bellows 1, for accommodating Cherenkov's fluorescence detection device and object under test；
The intensifying screen 2, for gathering the γ photons of nucleic transmitting, and is converted into fluorescence signal by it；The intensifying screen 2
For cylindrical green-series rare earth intensifying screen；Its composition is gadolinium oxysulfide, is decayed institute by nucleic using gadolinium oxysulfide rare earth material
The γ lines of transmitting, which are excited, can produce the characteristic of fluorescence signal, and intensifying screen is made in gadolinium oxysulfide rare earth material.Intensifying screen 2 is placed in
At morbidity, the gamma-rays that radionuclide decay is sent can be converted to fluorescence signal.
The endoscope 3, for gathering signal, and carries out lossless maximization optical signalling transmission；The endoscope 3 is
Medical fibre endoscope, the endoscope lens are coupled with the intensifying screen 2.Nucleic decay is sent in patient's body to be diagnosed
γ lines penetrate human body and reach intensifying screen 2, excite gadolinium oxysulfide rare earth material above and send fluorescence, the collection fluorescence of endoscope 3
It is transferred to Scientific Grade optics ANDOR CCD cameras to be imaged, medical fibre endoscope can ensure to collect glimmering to greatest extent
Light simultaneously carries out loss-free being transferred to CCD camera.The substep situation for waiting to diagnose nucleic in patient body can be captured, is realized in medical
Surfing style radioluminescence is imaged.
The CCD camera 4, for control signal collection and optical imagery, and handles the fluorescence data collected；It is described
CCD camera 4 is signal acquisition and the Scientific Grade optics ANDOR CCD cameras of optical imagery, and it uses brand-new design, and is integrated with
The advanced attribute of iXon series, while quantitative stability is ensured, pixel reading speed reaches 30MHz.It can collecting work
Temperature, time for exposure, aperture size, collection frame frequency and EM gains.
The computer 5, for the fusion output to data and image.
Present invention also offers a kind of imaging method of medical spy radioluminescence imaging system, it includes following step
Suddenly：
Step 1, when intensifying screen is not installed, endoscope collection white light；It is transferred to after endoscope probe collection white light through optical fiber
Scientific Grade optics ANDOR CCD cameras simultaneously treat imaging object progress optical imagery, obtain white light figure；
Step 2, intensifying screen is installed additional, the γ converting photons that nucleic is launched are fluorescence signal by intensifying screen；Endoscope probe is adopted
Scientific Grade optics ANDOR CCD cameras are transferred to through light after collection fluorescence and treat imaging object and carry out optical imagery, obtain glimmering
Light figure；
Step 3, binaryzation is carried out to white light figure, corrosion separates noise regions and target area, prevents noise regions and target area
Adhesion and cause noise regions not eliminate, calculate binary map in connected region number, connected region area is then calculated again, is asked
The area of the maximum connected region of area, and the maximum region of area is chosen, then target area interior void is filled, for upper
The corrosion in face carries out expansion reduction, and it is area-of-interest to extract boundary graph；
Step 4, denoising is carried out to fluorogram, subtracts background value, plus pseudo-colours；Specific method：Medium filtering removes highlighted
Point；It is one piece of region of artificial selection to subtract background value, draws average value, then full figure subtracts this value；Plus pseudo-colours is first pre-
An iris colormap is first defined, is then mapped；
Step 5, the area-of-interest that the white light figure is chosen is extracted and merged on fluorogram, matched somebody with somebody
Image after standard.
Clinically, patient is first in the camera bellows of lucifuge, is then treated with the intensifying screen alignment needs before endoscope lens
Position is surveyed, patient 5-15s time remains stationary as, then medical personnel's operating computer of outside is acquired data, is collected
Can just allow patient to come out afterwards, with avoid asphyxia the problems such as；And doctor can just immediately know that this while patient comes out
Whether patient suffers from hyperthyroidism disease.
A kind of medical spy radioluminescence imaging system of the present invention can realize the radioluminescence imaging of medical nucleic, bag
Include the imaging of the radionuclides such as FDG, Tc, I conventional in radiodiagnosis；Overcome conventional nucleic-optical imagery (Cherenkov
Imaging strategies) in, the shortcoming that imaging nucleic is few, image taking speed is slow, light signal strength is low, signal penetrability is not enough；Can with gram
Take the biological safety bottleneck of reinforcing element in conventional nucleic-optical imagery signal enhancing strategy (mainly nano particle etc.)；
Open the new application of endoscope.
It should be appreciated that the above-mentioned embodiment of the present invention is used only for exemplary illustration or explains the present invention's
Principle, without being construed as limiting the invention.Therefore, that is done in the case of the thought and scope without departing from the present invention is any
Modification, equivalent substitution, improvement etc., should be included in the scope of the protection.In addition, appended claims purport of the present invention
Covering the whole changes fallen into scope and border or this scope and the equivalents on border and repairing
Change.
Claims (8)
1. a kind of medical spy radioluminescence imaging system, it is characterised in that：It is included with lower component, camera bellows, and it is used to hold
Receive Cherenkov's fluorescence detection device and object under test；
Intensifying screen, at the morbidity of object under test, the γ photons for gathering nucleic transmitting, and be fluorescence by γ converting photons
Signal；
Endoscope, it is used to gather fluorescence signal, and the lossless maximization of fluorescence signal is transferred into CCD camera；
CCD camera, it handles the fluorescence signal being collected into, and carries out optical imagery；Meanwhile, the data and image after processing are defeated
Go out to computer；
Computer, it is used for the fusion treatment to data and image；
The endoscope and intensifying screen are in camera bellows, and one end of endoscope is removably of coupled connections with intensifying screen, interior
The other end of sight glass is connected with the CCD camera outside the camera bellows by optical fiber, and the CCD camera is electrically connected with computer
Connect.
2. a kind of medical spy radioluminescence imaging system according to claim 1, it is characterised in that：The intensifying screen
For cylindrical green-series rare earth intensifying screen.
3. a kind of medical spy radioluminescence imaging system according to claim 1, it is characterised in that：The intensifying screen
Composition in include gadolinium oxysulfide.
4. a kind of medical spy radioluminescence imaging system according to claim 1, it is characterised in that：The endoscope
For medical fibre endoscope.
5. a kind of medical spy radioluminescence imaging system according to claim 1, it is characterised in that：The CCD phases
The pixel reading speed of machine is 30MHz, and the CCD camera can be big according to signal collected intensity adjustment time for exposure, aperture
Small, frame frequency and EM gains.
6. a kind of imaging method of medical spy radioluminescence imaging system, it is characterised in that：It comprises the following steps：
S1, object under test is directed at by endoscope, gathers white light；
S2, the white light that CCD camera is gathered according to endoscope carries out optical imagery, obtains white light figure；
S3, installs intensifying screen before endoscope, and intensifying screen is aligned into object under test, and intensifying screen turns the γ photons that nucleic is launched
Turn to fluorescence signal；
S4, endoscope collection fluorescence signal；
S5, the fluorescence signal that endoscope is collected is transferred to CCD camera through optical fiber, and CCD camera carries out fluorescence imaging, obtains nucleic
Fluorogram；
White light figure obtained by step S2 and step S5 and nucleic fluorogram are carried out image procossing and obtain registration by S6, computer
Figure；
S7, is exported the registration figure using computer.
7. a kind of imaging method of medical spy radioluminescence imaging system according to claim 6, it is characterised in that：
The detailed process of image procossing is as follows in the step S6：
S01, selects nucleic fluorogram, and carries out denoising, background subtraction value plus pseudo-colours, obtains the image I1 with valid data；
S02, area-of-interest is extracted from white light figure, obtains image I3；
S03, useful signal region is found in image I1 and obtains image I2；
S04, image I2 fusions are added on image I3, registering figure is obtained.
8. a kind of imaging method of medical spy radioluminescence imaging system according to claim 7, it is characterised in that：
Described image I3 is to be based on each image significance and relative position in white light figure, color combining and textural characteristics, is given birth to using region
Regular way extracts gained.
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| BR112019000143A2 (en) * | 2016-07-07 | 2019-04-16 | Memorial Sloan Kettering Cancer Center | imaging systems and methods for knowledge-based and predictive particle-driven cancer radiogenomy |
| CN106308731A (en) * | 2016-08-31 | 2017-01-11 | 北京数字精准医疗科技有限公司 | Endoscopic multi-spectrum excited imaging system |
| CN106510633B (en) * | 2016-11-29 | 2019-09-17 | 中国人民解放军第四军医大学 | A kind of high-resolution spoke light imaging system and its imaging method and application |
| CN106491094A (en) * | 2016-11-30 | 2017-03-15 | 西北大学 | A kind of medical radionuclide imaging system based on radiofluorescence material coated plate |
| CN106725257A (en) * | 2016-12-12 | 2017-05-31 | 中国人民解放军第四军医大学 | A kind of gasbag-type white light-multi-modal endoscopic imaging system of spoke light |
| CN107569210A (en) * | 2017-07-25 | 2018-01-12 | 西北大学 | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding |
| CN109003230A (en) * | 2018-06-07 | 2018-12-14 | 西安电子科技大学 | A kind of Cherenkov's fluorescent image impact noise minimizing technology and system |
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| JPH04132987A (en) * | 1990-09-25 | 1992-05-07 | Olympus Optical Co Ltd | Radiation detecting probe |
| US5694933A (en) * | 1995-04-28 | 1997-12-09 | Care Wise Medical Products Corporation | Apparatus and methods for determining spatial coordinates of radiolabelled tissue using gamma-rays and associated characteristic X-rays |
| JP2001330677A (en) * | 2000-05-24 | 2001-11-30 | Canon Inc | Radiation detector |
| AU2003224348A1 (en) * | 2002-05-02 | 2003-11-17 | Csir | Bone densitometry and mammography |
| JP2006519032A (en) * | 2002-12-02 | 2006-08-24 | エダ リサーチ アンド ディベロップメント カンパニー リミティド | Characterization of arteriosclerosis by optical imaging |
| EP2586358A1 (en) * | 2010-06-25 | 2013-05-01 | Konica Minolta Advanced Layers, Inc. | Probe, diagnosis device, and method for using the diagnosis device |
| CN102429668B (en) * | 2011-07-28 | 2014-05-07 | 中国科学院自动化研究所 | Functional-molecular-structural imaging system and method |
| CN103315711B (en) * | 2013-06-26 | 2015-07-01 | 西安电子科技大学 | Medical endoscopic Cherenkov fluorescence imaging system |
| CN104027064B (en) * | 2014-06-27 | 2015-11-04 | 中国科学院自动化研究所 | Planar imaging method is peeped based in Cerenkov effect |
| CN104739516A (en) * | 2015-03-26 | 2015-07-01 | 刘侠 | Endoscopic surgery navigation system and method based on Cherenkov effect |
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