CN108806776A - A method of the Multimodal medical image based on deep learning - Google Patents

A method of the Multimodal medical image based on deep learning Download PDF

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Publication number
CN108806776A
CN108806776A CN201810611120.3A CN201810611120A CN108806776A CN 108806776 A CN108806776 A CN 108806776A CN 201810611120 A CN201810611120 A CN 201810611120A CN 108806776 A CN108806776 A CN 108806776A
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image
deep learning
medical image
image based
multimodal medical
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张水兴
张斌
方进
张璐
莫笑开
陈秋颖
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First Affiliated Hospital of Jinan University
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First Affiliated Hospital of Jinan University
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/30Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/97Determining parameters from multiple pictures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10081Computed x-ray tomography [CT]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10088Magnetic resonance imaging [MRI]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30096Tumor; Lesion

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Primary Health Care (AREA)
  • Quality & Reliability (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Pathology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
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Abstract

The invention discloses a kind of methods of the Multimodal medical image based on deep learning, include the following steps:S1:Image capturing:The medical image of patient's detection position, S2 are obtained using CT scan and mr imaging technique:Image processing:The two width images obtained using CT scan and mr imaging technique described in S1 are pre-processed, S3:Feature extraction:To treated described in S2, two width images carry out internal feature extraction and surface extraction, S4:Image alignment:The surface of the two width images extracted described in S3 is aligned, the internal feature that two width image of method pair is aligned using image segmentation alignment and pixel characteristic is aligned.The present invention is merged by the medical image to acquisition, and the image data of fusion is shown in the same three dimensions, forms 3-D view, more intuitively can be carried out comprehensive analysis to image, can be made diagnosis faster.

Description

A method of the Multimodal medical image based on deep learning
Technical field
The present invention relates to Multimodal medical image technical field more particularly to a kind of multi-modal medicine based on deep learning The method of image.
Background technology
Currently, with accurate medical treatment and the arriving in big data epoch, other than diagnosing text information, the analysis of image data And application has become one of the link of clinical medicine more core.Medical staff is as needed to these medical images into pedestrian Work identifies, to be diagnosed to corresponding sufferer.Since the daily medical image quantity of hospital is thousands of, workload is very big, examines It is disconnected less efficient.In order to reduce the workload of medical staff, now it is badly in need of a kind of medical image recognition methods, through retrieval, application number 201710071847.2 patent document discloses a kind of Multimodal medical image recognition methods based on deep learning, including: Multimodal medical image based on patient position to be detected is using method for registering by Multimodal medical image in same three dimensions Interior display utilizes R-CNN based on Multimodal medical image, the lesion region in Multimodal medical image is identified, according to diseased region Coordinate of the domain in Multimodal medical image lesions showed body in same three dimensions, it is corresponding according to the lesion region made a definite diagnosis Image block obtains the probability of happening of each default disease using the dense method of sampling and CNN.The present invention provides a kind of based on depth The Multimodal medical image identification device of habit, including:Multimodal medical image display module, lesion region detection module, lesion Body display module presets disease probability of happening module.The present invention realizes the automatic identification of lesion region in medical image, and is The further diagnosis of doctor provides effective reference data, but this recognition methods is not easy to merge image, no More intuitively image can be observed, extend Diagnostic Time.
Invention content
Technical problems based on background technology, the present invention propose a kind of multi-modal medicine shadow based on deep learning The method of picture.
A kind of method of Multimodal medical image based on deep learning proposed by the present invention, includes the following steps:
S1:Image capturing:Patient's detection position is obtained using CT scan and mr imaging technique Medical image;
S2:Image processing:To what is obtained using CT scan and mr imaging technique described in S1 Two width images are pre-processed;
S3:Feature extraction:Internal feature extraction is carried out to treated described in S2 two width images and surface carries It takes;
S4:Image alignment:The surface of the two width images extracted described in S3 is aligned, image point is utilized The internal feature for cutting alignment and pixel characteristic alignment two width image of method pair is aligned;
S5:Visual fusion:After surface described in the S4 is aligned completion with internal feature, two width images are carried out Fusion, the image data of fusion is shown in the same three dimensions, forms 3-D view;
S6:Image analysing computer:Comprehensive analysis is carried out to the 3-D view described in S5, makes diagnosis.
Preferably, in the S1, carry out CT scan when, using the X-ray beam of Accurate collimation, gamma-rays, Ultrasonic wave makees profile scanning one by one together with detector around detection position.
Preferably, it in the S1, when carrying out magnetic resonance imaging, is obtained from the position to be detected of human body using electromagnetic induction phenomenon Electromagnetic signal, and reconstruct human body information.
Preferably, in the S2, when being pre-processed to image, to image into row format, filtering, brightness processed.
Preferably, in the S3, internal feature extraction is mainly with human anatomic structure feature, such as:Skull, backbone, chest Soft tissue under bone, rib cage, joint and diaphragm.
Preferably, in the S2, when handling image, initial error correction, geometric transformation school are carried out to image Just.
Preferably, it in the S5, when carrying out visual fusion, needs to assess the error of fusion.
Preferably, it when being filtered to image, needs that signal is kept not suffer a loss, the profile of image cannot be damaged With marginal information.
Beneficial effects of the present invention:It is merged by the medical image to acquisition, by the image data of fusion same Display in a three dimensions, forms 3-D view, more intuitively can carry out comprehensive analysis to image, can make faster Diagnosis.
Specific implementation mode
The present invention is made further to explain with reference to specific embodiment.
Embodiment
A kind of method of the Multimodal medical image based on deep learning is proposed in the present embodiment, is included the following steps:
S1:Image capturing:Patient's detection position is obtained using CT scan and mr imaging technique Medical image;
S2:Image processing:To what is obtained using CT scan and mr imaging technique described in S1 Two width images are pre-processed;
S3:Feature extraction:Internal feature extraction is carried out to treated described in S2 two width images and surface carries It takes;
S4:Image alignment:The surface of the two width images extracted described in S3 is aligned, image point is utilized The internal feature for cutting alignment and pixel characteristic alignment two width image of method pair is aligned;
S5:Visual fusion:After surface described in the S4 is aligned completion with internal feature, two width images are carried out Fusion, the image data of fusion is shown in the same three dimensions, forms 3-D view;
S6:Image analysing computer:Comprehensive analysis is carried out to the 3-D view described in S5, makes diagnosis.
In the present embodiment, in S1, carry out CT scan when, using the X-ray beam of Accurate collimation, gamma-rays, Ultrasonic wave makees profile scanning one by one together with detector around detection position, in S1, when carrying out magnetic resonance imaging, and profit Electromagnetic signal is obtained from the position to be detected of human body with electromagnetic induction phenomenon, and reconstructs human body information, in S2, is carried out to image When pretreatment, to image into row format, filtering, brightness processed, in S3, internal feature extraction is mainly with human anatomic structure spy Sign, such as:Soft tissue under skull, backbone, breastbone, rib cage, joint and diaphragm in S2, when handling image, carries out image Initial error is corrected, geometric transformation correction, in S5, when carrying out visual fusion, needs to assess the error of fusion, right When image is filtered, needs that signal is kept not suffer a loss, the profile and marginal information of image cannot be damaged, it is of the invention Advantageous effect is merged by the medical image to acquisition, and the image data of fusion is shown in the same three dimensions Show, form 3-D view, can comprehensive analysis more intuitively be carried out to image, diagnosis can be made faster.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (8)

1. a kind of method of the Multimodal medical image based on deep learning, which is characterized in that include the following steps:
S1:Image capturing:The medicine of patient's detection position is obtained using CT scan and mr imaging technique Image;
S2:Image processing:To two width obtained using CT scan and mr imaging technique described in S1 Image is pre-processed;
S3:Feature extraction:To treated described in S2, two width images carry out internal feature extraction and surface extraction;
S4:Image alignment:The surface of the two width images extracted described in S3 is aligned, image segmentation pair is utilized The internal feature of neat and pixel characteristic alignment two width image of method pair is aligned;
S5:Visual fusion:After surface described in the S4 is aligned completion with internal feature, two width images are melted It closes, the image data of fusion is shown in the same three dimensions, form 3-D view;
S6:Image analysing computer:Comprehensive analysis is carried out to the 3-D view described in S5, makes diagnosis.
2. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S1, when carrying out CT scan, using the X-ray beam, gamma-rays, ultrasonic wave of Accurate collimation together with detector Make profile scanning one by one around detection position.
3. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S1, when carrying out magnetic resonance imaging, obtains electromagnetic signal from the position to be detected of human body using electromagnetic induction phenomenon, and reconstruct Human body information.
4. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S2, when being pre-processed to image, to image into row format, filtering, brightness processed.
5. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S3, internal feature extraction is mainly with human anatomic structure feature, such as:Under skull, backbone, breastbone, rib cage, joint and diaphragm Soft tissue.
6. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S2, when handling image, initial error correction, geometric transformation correction is carried out to image.
7. a kind of method of Multimodal medical image based on deep learning according to claim 1, which is characterized in that institute It states in S5, when carrying out visual fusion, needs to assess the error of fusion.
8. a kind of method of Multimodal medical image based on deep learning according to claim 4, which is characterized in that When being filtered to image, needs that signal is kept not suffer a loss, the profile and marginal information of image cannot be damaged.
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Cited By (8)

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CN109859168A (en) * 2018-12-28 2019-06-07 上海联影智能医疗科技有限公司 A kind of X-ray rabat picture quality determines method and device
CN111358484A (en) * 2020-03-23 2020-07-03 广州医科大学附属第一医院(广州呼吸中心) Nuclear medicine lung perfusion imaging quantitative analysis method, analysis equipment and storage medium
CN111369546A (en) * 2020-03-10 2020-07-03 北京邮电大学 Neck lymph node image classification and identification device and method
CN111415727A (en) * 2020-03-13 2020-07-14 广州医科大学附属肿瘤医院 Multi-mode image data management system and analysis method
CN111863205A (en) * 2020-07-23 2020-10-30 山东协和学院 Accurate image recognition system and image recognition method
CN111914925A (en) * 2020-07-28 2020-11-10 复旦大学 Patient behavior multi-modal perception and analysis system based on deep learning
CN113384261A (en) * 2021-05-28 2021-09-14 华南理工大学 Centrum compression fracture multi-mode intelligent diagnosis system based on deep learning
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109859168A (en) * 2018-12-28 2019-06-07 上海联影智能医疗科技有限公司 A kind of X-ray rabat picture quality determines method and device
US11436720B2 (en) 2018-12-28 2022-09-06 Shanghai United Imaging Intelligence Co., Ltd. Systems and methods for generating image metric
CN111369546A (en) * 2020-03-10 2020-07-03 北京邮电大学 Neck lymph node image classification and identification device and method
CN111369546B (en) * 2020-03-10 2023-07-18 北京邮电大学 Cervical lymph node image classification and identification device and method
CN111415727A (en) * 2020-03-13 2020-07-14 广州医科大学附属肿瘤医院 Multi-mode image data management system and analysis method
CN111358484A (en) * 2020-03-23 2020-07-03 广州医科大学附属第一医院(广州呼吸中心) Nuclear medicine lung perfusion imaging quantitative analysis method, analysis equipment and storage medium
CN111358484B (en) * 2020-03-23 2021-12-24 广州医科大学附属第一医院(广州呼吸中心) Nuclear medicine lung perfusion imaging quantitative analysis method, analysis equipment and storage medium
CN111863205A (en) * 2020-07-23 2020-10-30 山东协和学院 Accurate image recognition system and image recognition method
CN111914925A (en) * 2020-07-28 2020-11-10 复旦大学 Patient behavior multi-modal perception and analysis system based on deep learning
CN113384261A (en) * 2021-05-28 2021-09-14 华南理工大学 Centrum compression fracture multi-mode intelligent diagnosis system based on deep learning

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Application publication date: 20181113