CN213721905U - Cherenkov fluorescence imaging device and medical imaging system - Google Patents
Cherenkov fluorescence imaging device and medical imaging system Download PDFInfo
- Publication number
- CN213721905U CN213721905U CN202021342554.7U CN202021342554U CN213721905U CN 213721905 U CN213721905 U CN 213721905U CN 202021342554 U CN202021342554 U CN 202021342554U CN 213721905 U CN213721905 U CN 213721905U
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- image
- white light
- cerenkov
- fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The utility model discloses a Cerenkov fluorescence imaging device and medical imaging system, this Cerenkov fluorescence imaging device can include: the optical signal comprises a Cherenkov fluorescence signal emitted from the inside of a target object and a white light signal emitted from the surface of the target object; the optical fiber image transmission bundle comprises at least one optical fiber for transmitting the Cerenkov fluorescence signal and the white light signal collected by the collecting part, wherein the diameter of the optical fiber image transmission bundle is 0.06 mm-8 mm; and the image sensor is connected with the optical fiber image transmission beam to image the Cerenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission beam. Through utilizing the utility model provides a technical scheme can improve the accuracy of Cerenkov fluorescence testing result to help the supplementary doctor to diagnose.
Description
Technical Field
The utility model relates to an optics molecular image technical field, in particular to cheenkov fluorescence imaging device and medical imaging system.
Background
In recent years, molecular imaging technology has been developed into an important imaging technology for diagnosing, monitoring and treating cancer, nerve, cardiovascular and other diseases, and early accurate detection and treatment of tumor cells can be realized by combining with traditional imaging technologies such as Magnetic Resonance Imaging (MRI), X-ray computed tomography, Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), gamma camera and the like, so that people are receiving wide attention and research.
As a branch of the molecular imaging technology field, the optical molecular imaging technology has the advantages of high specificity, high sensitivity, high time resolution, low cost, safety, no wound and the like, and is widely applied to the fields of small animal research, human clinical/preclinical research and the like. However, the optical molecular imaging technology still faces a great challenge to clinical application due to the extremely limited optical probes that can be applied to the human body.
The Cerenkov Luminescence Imaging (CLI) technology provides possibility for solving the problem, can carry out Imaging by detecting Cerenkov Luminescence generated in the nuclear decay process of some radioactive nuclides, and has all the advantages of the optical molecular Imaging technology. However, since the intensity of the Cerenkov fluorescence is weak and the attenuation rate of the Cerenkov fluorescence is large during transmission, the Cerenkov fluorescence is difficult to penetrate deep biological tissues, so that the accuracy of detection results can be reduced, and the diagnosis results of doctors can be affected.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a Cerenkov fluorescence imaging device and medical imaging system to improve the accuracy of Cerenkov fluorescence testing result.
The utility model provides a Cherenkov fluorescence imaging device, this Cherenkov fluorescence imaging device can include:
the optical signal comprises a Cerenkov fluorescence signal emitted from the inside of a target object and a white light signal emitted from the surface of the target object;
the optical fiber image transmission bundle comprises at least one optical fiber for transmitting the Cerenkov fluorescence signal and the white light signal collected by the collecting part, wherein the diameter of the optical fiber image transmission bundle is 0.06-8 mm;
an image sensor connected with the optical fiber image transmission bundle to image the Cerenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission bundle.
Optionally, the optical fiber has a diameter of 6 mm.
Optionally, the apparatus further comprises:
an illumination light source disposed on the collecting part and for irradiating white light to the target object.
Optionally, the apparatus further comprises:
and a processing unit connected to the image sensor to perform fusion processing on the Cerenkov fluorescence image and the white light image obtained by the image sensor.
Optionally, the apparatus further comprises:
a relay lens group including at least one lens and disposed between the optical fiber image transmitting bundle and the image sensor.
Optionally, the apparatus further comprises:
and two ends of the optical adapter are respectively coupled with the optical fiber image transmission bundle and the image sensor.
Optionally, the device comprises a medical endoscope, fiberscope, or borescope.
Optionally, the image sensor comprises a CCD camera or an EMCCD camera.
The utility model also provides a medical imaging system, the system can include above-mentioned Cerenkov fluorescence imaging device and be used for with Cerenkov fluorescence imaging device surveys together the radiation detection device of target object.
Optionally, the radiation detection apparatus comprises an MRI device, a CT device, a SPECT device, a PET device or a PET-CT device.
According to the technical scheme provided by the utility model, the utility model utilizes the acquisition part to acquire the Cerenkov fluorescence signal emitted from the target object and the white light signal emitted from the surface of the target object; transmitting the Cherenkov fluorescence signal and the white light signal collected by the collecting part by using an optical fiber image transmission bundle, wherein the diameter of the optical fiber image transmission bundle is 0.06 mm-8 mm; the image sensor is used for imaging the Cherenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission beam to obtain a Cherenkov fluorescence image and a white light image, so that the accuracy of the Cherenkov fluorescence detection result can be improved, and the diagnosis of a doctor is assisted.
Drawings
In order to more clearly illustrate the technical solutions of the present invention or the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive labor.
Fig. 1 is a schematic structural diagram of a chencov fluorescence imaging device provided in an embodiment of the present invention;
FIG. 2 is a schematic cross-sectional view of an optical fiber image-transmitting bundle;
FIG. 3 is a schematic cross-sectional view of another optical fiber image-transmitting bundle;
fig. 4 is a schematic structural diagram of a cherenkov fluorescence imaging device provided in another embodiment of the present invention;
FIG. 5 is a schematic illustration of an obtained Cerenkov fluorescence image;
fig. 6 is a schematic structural diagram of a cherenkov fluorescence imaging device provided in yet another embodiment of the present invention;
fig. 7 is a schematic structural diagram of a medical imaging system provided in an embodiment of the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings in the present application, and it is obvious that the described embodiments are only used for explaining some embodiments of the present invention, but not all embodiments, and are not intended to limit the scope of the present invention or the claims. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
It will be understood that when an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected/coupled" to another element, it can be directly connected/coupled to the other element or intervening elements may also be present. The term "connected/coupled" as used herein may include electrical and/or mechanical physical connections/couplings. The term "comprises/comprising" as used herein refers to the presence of features, steps or elements, but does not preclude the presence or addition of one or more other features, steps or elements. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
In addition, in the description of the present invention, the terms "first", "second", "third", and the like are used for descriptive purposes only and to distinguish similar objects, and there is no order of precedence between the two, and no indication or implication of relative importance is to be inferred. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.
The present invention provides a cheenkov fluorescence imaging apparatus and a medical imaging system, which are described below with reference to the accompanying drawings.
As shown in fig. 1, the present invention provides a chemberfkov fluorescence imaging device, which may be a medical fiber endoscope, and may include an acquisition portion 100, an optical fiber image bundle 200, and an image sensor 300. Wherein, the collecting part can be used for collecting the Cerenkov fluorescence signal emitted from the target object and the white light signal emitted from the surface of the target object, and is provided with a filter structure 110 for collecting the optical signal with specific wavelength and an objective lens 120 for focusing the optical signal passing through the filter structure 120 on the optical fiber image transmission beam 200, and the optical signal can comprise the Cerenkov fluorescence signal and the white light signal emitted from the target object; the optical fiber image transmission bundle 20 may include at least one optical fiber for transmitting the cerenkov fluorescence signal and the white light signal collected by the collecting part 100, and the diameter of the optical fiber image transmission bundle 200 may be 0.06mm to 8 mm; and an image sensor 300 which can be connected with the optical fiber image transmission bundle 200 to image the optical signals such as the Cerenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission bundle 200 so as to obtain the optical images such as the Cerenkov fluorescence image and the white light image.
The diameter of the optical fiber image transmission bundle 200 is set within 0.06-8 mm, so that the attenuation rate of the Cerenkov fluorescence signal in the transmission process can be reduced, the accuracy of the Cerenkov fluorescence detection result can be improved, and the diagnosis by a doctor can be assisted.
The filtering structure 110 on the collecting part 100 may be a component having a filtering function, for example, a narrow band filter or a filter, so that only light of a specific wavelength (for example, cerenkov fluorescence and white light) is allowed to pass through, and light of other wavelengths is isolated. The objective lens 120 may comprise at least one optical lens, and the objective lens 120 may be used to focus an optical signal passing through the filter structure 110 on an optical fiber within the optical fiber image bundle 200. In addition, an illumination light source (not shown) may be disposed on the collecting part 100, may be located in an illumination passage (e.g., upper and lower sides) disposed thereon, and may be a cold light source emitting white light, a Light Emitting Diode (LED), or an Organic Light Emitting Diode (OLED). By arranging the illumination light source on the acquisition part 100, an external light source and a light guide beam can be omitted, so that the internal structure of the Cerenkov fluorescence imaging device can be simplified, the brightness of the Cerenkov fluorescence imaging device at the periphery of the Cerenkov fluorescence imaging device during working can be fully ensured, and the imaging quality can be ensured.
The optical fiber image transmission bundle 200 can be used for transmitting optical signals such as the cerenkov fluorescence signal and the white light signal obtained by the acquisition unit 100. The optical fiber image-transmitting bundle 200 may include one or more optical fibers 210 and a protective layer 220 covering the optical fibers 210. These optical fibers 210 have high luminous flux and light collection efficiency and may be arranged in a polygonal shape as shown in fig. 2 and 3, but are not limited to the two shapes shown in the drawings, and may be arranged in a square shape, for example, so that the efficiency of transmitting optical signals may be improved. The protective layer 220 may serve to prevent the optical fiber 210 from being damaged due to the external environment.
The diameter of the optical fiber image-transmitting bundle 220 may be 0.06mm to 8mm, and preferably may be 6 mm. The diameter range of the fiber optic image transmission bundle 220 is determined experimentally, and it has been proved by related experiments that the intensity of detected Cerenkov fluorescence is highest when the diameter thereof is 6mm, and insertion into the tissue of the target organism is facilitated.
The image sensor 300 may include a Charge Coupled Device (CCD) camera or an Electron Multiplying Charge Coupled Device (EMCCD) camera, etc., but is not limited thereto. By using the image sensor 300, the sharpness of the obtained image can be improved, and the obtained image has an enlarging effect, thereby helping a doctor to make a diagnosis.
In another embodiment of the present invention, as shown in fig. 4, the cerenkov fluorescence imaging device may further include a processing portion 400, which may be connected to the image sensor 300 to process optical images such as cerenkov fluorescence image and white light image obtained by the image sensor 300. For example, the processing unit 400 may perform processing such as denoising and/or distortion correction on the cerenkov fluorescence image to obtain a processed cerenkov fluorescence image, may perform processing such as denoising and/or distortion correction on the cerenkov fluorescence image, and then perform fusion processing on the processed cerenkov fluorescence image and the white light image to obtain a cerenkov fluorescence registration image, and may further display the obtained cerenkov fluorescence registration image. With regard to the specific manner of denoising, distortion correction and fusion processing of the images, reference may be made to the corresponding description in the prior art, which is not described again herein. The processing unit 400 may perform the corresponding processing on the cerenkov fluorescence image according to actual needs, and is not limited to the preprocessing and the fusion processing.
The processing unit 400 may be any computing device (e.g., a computer) having computing capabilities, or may be a part of the computing device, such as a processor.
Fig. 5 shows a cerenkov fluorescence image of a tumor tissue, organs such as liver, kidney, heart, brain, and muscle tissue obtained after the processing by the processing unit 400.
In another embodiment of the present invention, as shown in fig. 6, the cerenkov fluorescence imaging apparatus may further include a relay lens group 500, which may be disposed between the optical fiber image transmitting bundle 200 and the image sensor 300, and may include at least one optical lens. By using the relay lens assembly 500, the optical image transmitted by the optical fiber image transmitting bundle 200 can be better transmitted to the image sensor 300.
In addition, the cherenkov fluorescence imaging device may further include an optical adapter (not shown), both ends of which may be respectively coupled with the optical fiber image transmission bundle 200 and the image sensor 300, so that the optical fiber image transmission bundle 200 and the image sensor 300 may be fixed, and a focal length adjustment function may be performed, so that the obtained optical image may be clearer. In the case where the relay lens group 500 is provided, an optical adapter may be provided between the optical fiber image bundle 200 and the relay lens group 500 and between the relay lens group 500 and the image sensor 300, so as to indirectly fix the optical fiber image bundle 200 and the image sensor 300. The optical adapter may take any configuration commonly used in the art, and its specific configuration is not limited herein.
As can be seen from the above description, the present invention collects the cerenkov fluorescence signal emitted from the inside of the target object and the white light signal emitted from the surface of the target object by using the collecting part; transmitting the Cherenkov fluorescence signal and the white light signal collected by the collecting part by using an optical fiber image transmission beam; the image sensor is used for imaging the Cerenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission beam to obtain the Cerenkov fluorescence image and the white light image, and the diameter of the optical fiber image transmission beam is set to be 0.06 mm-8 mm, so that the loss of Cerenkov fluorescence in the transmission process can be reduced, the accuracy of the Cerenkov fluorescence detection result can be improved, and the accuracy of the diagnosis result of a doctor can be improved.
The utility model also provides a medical imaging system, as shown in figure 7, this medical imaging system can include the Cerenkov fluorescence imaging device that describes in the above-mentioned embodiment and be used for surveying the radiation detection device of target object together with Cerenkov fluorescence imaging device. The nuclear radiation detection device may be any device capable of detecting radioactive rays, which may be an MRI device, a CT device, a SPECT device, a PET device, or a PET-CT device, for example.
When the target object is detected by the aid of the Cerenkov fluorescence imaging device, the target object can be subjected to radiation detection by the aid of the radiation detection device, so that doctors can refer to detection results of the radiation detection device during diagnosis, and accuracy of diagnosis results can be improved.
It is noted that the target object may be any organism, e.g. a patient, injected with a radiotracer. The radiotracer may be a radionuclide capable of emitting radioactive radiation at various concentrations, for example, it may be18F-FDG solution, or alternatively a combination of a radionuclide and a specific fluorescent material which fluoresces Cerenkov under excitation by the radioactive radiation emitted by the radionuclide, which may be Gd, for example2O2Tb particles, which enhances the detected Cerenkov fluorescenceThe intensity of the optical signal can improve the accuracy of the detection result, thereby being beneficial to assisting a doctor to diagnose.
In addition, the drawings are only schematic, and although the elements in the devices shown in the drawings are separated from each other, the elements may be directly connected or coupled or indirectly connected or coupled through the related elements, and the specific arrangement mode may refer to the arrangement mode of the corresponding elements in the prior art.
The systems, devices, apparatuses, units and the like set forth in the above embodiments may be specifically implemented by semiconductor chips, computer chips and/or entities, or implemented by products with certain functions. For convenience of description, the above devices are described as being divided into various units by function, and are described separately. Of course, the functions of the units may be implemented in the same or in a plurality of chips in implementing the present invention.
The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. In addition, the technical features of the above embodiments may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-described embodiments are described in order to enable those of ordinary skill in the art to make and use the invention. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention according to the disclosure of the present invention.
Claims (10)
1. A chencov fluorescence imaging apparatus, comprising:
the optical signal comprises a Cerenkov fluorescence signal emitted from the inside of a target object and a white light signal emitted from the surface of the target object;
the optical fiber image transmission bundle comprises at least one optical fiber for transmitting the Cerenkov fluorescence signal and the white light signal collected by the collecting part, wherein the diameter of the optical fiber image transmission bundle is 0.06-8 mm;
an image sensor connected with the optical fiber image transmission bundle to image the Cerenkov fluorescence signal and the white light signal transmitted by the optical fiber image transmission bundle.
2. The apparatus of claim 1, wherein the optical fiber has a diameter of 6 mm.
3. The apparatus of claim 1, further comprising:
an illumination light source disposed on the collecting part and for irradiating white light to the target object.
4. The apparatus of claim 1, further comprising:
and a processing unit connected to the image sensor to perform fusion processing on the Cerenkov fluorescence image and the white light image obtained by the image sensor.
5. The apparatus of claim 1, further comprising:
a relay lens group including at least one lens and disposed between the optical fiber image transmitting bundle and the image sensor.
6. The apparatus of claim 1, further comprising:
and two ends of the optical adapter are respectively coupled with the optical fiber image transmission bundle and the image sensor.
7. The device of claim 1, wherein the device comprises a medical endoscope, fiberscope, or borescope.
8. The apparatus of claim 1, wherein the image sensor comprises a CCD camera or an EMCCD camera.
9. A medical imaging system, characterized in that the system comprises a chemberfkov fluorescence imaging apparatus according to any of claims 1-8 and radiation detection means for detecting the target object together with the chemberfkov fluorescence imaging apparatus.
10. The system of claim 9, wherein the radiation detection device comprises an MRI device, a CT device, a SPECT device, a PET device, or a PET-CT device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021342554.7U CN213721905U (en) | 2020-07-09 | 2020-07-09 | Cherenkov fluorescence imaging device and medical imaging system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021342554.7U CN213721905U (en) | 2020-07-09 | 2020-07-09 | Cherenkov fluorescence imaging device and medical imaging system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213721905U true CN213721905U (en) | 2021-07-20 |
Family
ID=76814838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021342554.7U Active CN213721905U (en) | 2020-07-09 | 2020-07-09 | Cherenkov fluorescence imaging device and medical imaging system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213721905U (en) |
-
2020
- 2020-07-09 CN CN202021342554.7U patent/CN213721905U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100593389C (en) | Continuous dynamic gathering type beastie inducing fluorescence molecule imaging system | |
| US8046055B2 (en) | Lymph node detector | |
| US8041409B2 (en) | Method and apparatus for multi-modal imaging | |
| DE69925869T2 (en) | Laser imaging device using biomedical markers that bind to cancer cells | |
| JP2008537131A (en) | Optical imaging detector | |
| CN105105697B (en) | A kind of medical spy radioluminescence imaging system and its imaging method | |
| US10588585B2 (en) | Systems and methods that use multi-modal imaging for enhanced resolution images | |
| KR20150058174A (en) | Fibrescope for optical imaging of radiopharmaceuticals | |
| CN109044277B (en) | Near-infrared two-region fluorescence tomography system | |
| CN103300812A (en) | Endoscope-based multispectral video navigation system and method | |
| GB2254417A (en) | Photodynamic laser detection for cancer diagnosis | |
| WO2012168972A1 (en) | Radiation tomography image pick-up device | |
| CN102026582A (en) | Data collection method | |
| CN106361281B (en) | Fluorescence real time imagery, fusion method and device | |
| EP3417763A1 (en) | System for endoscopic imaging | |
| CN107569210A (en) | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding | |
| CN1882276A (en) | Lymph node detector | |
| CN102319058B (en) | Three-mode small animal imaging system integrating fluorescence, nuclei and X rays | |
| US20070093700A1 (en) | Computational optical biopsy | |
| JP5742660B2 (en) | Medical data processing apparatus and radiation tomography apparatus including the same | |
| US20080121806A1 (en) | Wavelength shifting lightguides for optimal photodetection in light-sharing applications | |
| CN106491094A (en) | A kind of medical radionuclide imaging system based on radiofluorescence material coated plate | |
| CN213721905U (en) | Cherenkov fluorescence imaging device and medical imaging system | |
| KR20140101930A (en) | Near-infrared Fluorescent Imaging Instrument for Surgical Guidance of Large Animal And Method for Imaging And Surgical Guidance thereof | |
| CN111759281A (en) | Signal detection device and system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |