CN205163039U - Diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system - Google Patents
Diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system Download PDFInfo
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- CN205163039U CN205163039U CN201520894141.2U CN201520894141U CN205163039U CN 205163039 U CN205163039 U CN 205163039U CN 201520894141 U CN201520894141 U CN 201520894141U CN 205163039 U CN205163039 U CN 205163039U
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Abstract
The utility model discloses a diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system, including main control computer, device controller, infrared imaging module, infrared ray emergence module and light power treatment module, the main control computer passes through serial bus connection with the device controller, the device controller is connected with light power treatment module, infrared ray emergence module respectively, the infrared imaging module is connected with the main control computer, the infrared imaging module is equipped with the image acquisition card who connects gradually, infrared CCD camera. The tumor of breast instrument that this diagnosis and treatment technology combined together, its application can realize respectively that tumor of breast nanometer target does not have the treatment of wound light power and surveys the diagnosis with visual nanometer target photosensitizer, and the development has the diagnosis tumor of breast diagnosis therapeutic equipment difunctional with the treatment, reach mammary gland blood oxygen function image, mammary gland blood oxygen nanometer reinforcing formation of image, mammary gland blood oxygen do not have create inspect, breast cancer nanometer target does not have the effect that wound light power was treated.
Description
Technical field
This utility model relates to medical field, has particularly related to a kind of breast tumor blood oxygen nanometer and has strengthened functional image Clinics and Practices system.
Background technology
According to investigation statistics, China suffers from breast cancer every year up to more than 210,000 people, and sicken age shifts to an earlier date 20 years old, ill rejuvenation.Because early symptom is not obvious and out in the cold, the patient of more than 85% has arrived middle and advanced stage to during examination in hospital, causes the mortality rate of breast carcinoma to rise year by year, has become the number one killer threatening women's life.In the face of so a kind of situation, the medical instruments and equipment of high end advanced how is utilized to carry out comprehensive breast screening to women movable, trying hard to be early discovery, early treatment to breast carcinoma is the task of top priority, and this is important measures of resisting breast carcinoma, protecting breast, reducing relapse rate and mortality rate.The means that existing breast examination uses are based on molybdenum target, ultrasonic.Although in breast screening, these two kinds of inspection methods have oneself local superiority, also receive certain limitation, such as: molybdenum target is responsive to calcification, but the body of gland type mammary gland level of Nails is differentiated not, have ray, belong to and have wound inspection, be unfit to do health check-up examination and use.The ultrasonic occupy-place reflection to cystic and solid is responsive, but higher to Doctors' skill level requirement, checks that speed is comparatively slow, and unsuitable extensive health check-up examination uses.Mammary gland dedicated magnetic resonates, and can find the tiny pathological changes of about 0.3cm, can check out that physical palpation gathers around the impalpable tumor nodule of hands, measurement in space can be carried out simultaneously, functional diagnosis, improves accuracy rate of diagnosis greatly, mammary cancer radical operation is protected advanced level that newborn rate reaches 60%-70%.But the price of its costliness is unfavorable for the generaI investigation application of clinical basic unit.
Domestic patent database disclosed some relevant patented technologies in recent years:
Such as [patent No.] CN2005100979817, [title] a kind of mammary gland blood-oxygen functional formation method and mammary gland blood-oxygen functional imaging system, this invention utilizes double-wavelength light source irradiated milk glandular tissue, rear detector receiving light power; Transfer Digital Signal Processing to again after transferring this light intensity to analogue signal again, by post processing of image, calculate oxygenate, deoxyhemoglobin variable quantity; Finally oxygenate, deoxyhemoglobin variable quantity are mapped to picture and generate figure; This system features is: include dual wavelength generator and computer assisted image processing system; Wherein dual wavelength generator is connected with described light source control module, and computer assisted image processing system is connected with described computer central processing system.The view data using the method and system to obtain is abundant, true, accurate and effective, carries out post processing provide good precondition for utilizing computer to scan-image.After the system increases image digitization technology, post-processing technology and blood oxygen analysis technology, improve diagnostic accordance rate.
Such as [patent No.] CN2010201208023, [title] two light source dual probe mammary gland blood-oxygen functional imaging system, this utility model relates to a kind of two light source dual probe mammary gland blood-oxygen functional imaging system, comprise: double-wavelength light source, double detector, blood oxygen and three ways of calculating subsignal collecting unit, computer and mammary gland information analysis processing system, it is characterized in that: in double detector, two outfans are connected as two inputs of capture card and an input of three ways of calculating subimage capture card with the oxigram in three ways of calculating subsignal collecting unit with blood oxygen respectively through video line, blood oxygen is connected with computer and mammary gland information analysis processing system respectively with three outfans of three ways of calculating subsignal collecting unit.This utility model provides a kind of two light source dual probe mammary gland blood-oxygen functional imaging system, for diagnosis provides a kind of efficient and convenient, practical, efficient breast image diagnostic device.
But above system is all the new diagnostic equipment of rapid screening early-stage breast cancer and various mastopathy, all without the function reaching treatment.
Summary of the invention
The present utility model object is to overcome the deficiencies in the prior art, there is provided one that Multifunctional galactophore blood-oxygen functional imaging system and near infrared light, nano target Imaging enhanced are combined with optical dynamic therapy, be better than the existing system for breast examination and treatment comprehensively, the early diagnosis accuracy rate of effective raising breast tumor and therapeutic effect, improve and protect newborn rate, and the effect that Clinics and Practices technology combines can be reached.
To achieve these goals, the present utility model have employed following technical scheme:
A kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, comprises main control computer, device controller, infrared imaging module, infrared ray generation module and optical dynamic therapy module; Described main control computer is connected by universal serial bus with device controller; Described device controller respectively with optical dynamic therapy module, infrared ray generation model calling; Described infrared imaging module is connected with main control computer by bus; Described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively.
Described main control computer provide the input of user interface, information, result output display and printing, galactophore image analysis and treament, with the communication of device controller and the data analysis of system and process.
Described device controller plays a kind of effect of gateway between main control computer and modules, equipment controls to be connected with computer by RS232 bus, be responsible for receiving the control command from computer and data, and according to received order, modules is controlled, read state and the data of modules simultaneously, then send main control computer to.Avoid modules be directly directly connected with main control computer and cause the complicated burden with increasing main control computer of line.
The function of infrared imaging module is the blood flow blood oxygen of collection lesion and is colored tumor tissues image, then gives main control computer and carries out treatment and analysis.
Further, described infrared CCD photographic head is provided with infrared fileter, makes gathered image not by the interference of extraneous visible ray, reduces background noise.
Further, described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively.The function of infrared ray drive circuit and infrared emitting probe is under the control of device controller, produce the infrared drive singal of characteristic frequency and pulsewidth, infrared emitting probe is driven to produce the infrared light of certain power and wavelength, and be irradiated to treatment target corresponding site, provide necessary light source for infrared CCD photographic head carries out infrared image acquisition.
Further, described photodynamic therapy system is provided with the drive circuit and optical dynamic therapy probe that connect successively.HONGGUANG or the near infrared light of specific wavelength and certain power is produced by optical dynamic therapy probe, irradiation is targeted nanometer liposome and dyes glaucous tumor tissues or tumor cell, sensitiser absorption in tumor tissues or tumor cell can produce photodynamic reaction (photochemical reaction) and generate active very strong singlet oxygen and (or) free radical after the light energy of this wavelength, singlet oxygen and multiple biomacromolecule generation oxidation reaction, and tumor cell kills by rapid temperature increases to certain temperature, and normal histiocyte is had no side effect and noinvasive damage.
Described targeted nano tumor staining agent a kind ofly has the micromolecule polypeptide of targeting to be the nanoparticle of targeting agent to breast carcinoma, carry oxygenation agent simultaneously, photosensitizer, targeting breast tissues in body is entered by local injection or the approach such as oral, targeted nano granule can automatic tracking of knub tissue or tumor cell, and combine with its surface receptor, tumor tissues or tumor cell are coloured to the aeruginous tissue (and normal structure does not absorb stain) of Glassless, increase the blood oxygen concentration of focus local simultaneously, at lesion region enrichment photosensitizer, obtain the high-resolution imaging of lesion, and the wavelength HONGGUANG simultaneously utilizing photodynamic therapy system to send or near infrared light, irradiate tumor tissues or tumor cell, sensitiser absorption in tumor tissues or tumor cell can produce photodynamic reaction (photochemical reaction) and generate active very strong singlet oxygen and (or) free radical after the light energy of this wavelength, singlet oxygen and multiple biomacromolecule generation oxidation reaction, and rapid temperature increases to certain temperature kills tumor cell, realize AT optical dynamic therapy.
Further, described diagnosis and therapy system also comprises infrared temperature detecting module, and described infrared temperature detecting module is connected with device controller.The function of infrared temperature detecting module carries out Real-Time Monitoring to the temperature of target area, and feed back to device controller and main control computer, for optical dynamic therapy module output provides reference data, make the output controlling optical dynamic therapy module better, improve therapeutic effect.
Utility model works principle:
Described infrared ray generation module, under the control of device controller, produces the infrared drive singal of characteristic frequency and pulsewidth, drives infrared emitting probe to produce the infrared light of certain power and specific wavelength, and is irradiated to treatment target corresponding site; Then, the blood flow of infrared imaging module acquires treatment target specific region, blood oxygen and the tumor tissues image be colored, then feed back to main control computer and carry out treatment and analysis; Again according to the analyzing and diagnosing result of main control computer, HONGGUANG or the near infrared light that optical dynamic therapy module produces specific wavelength and power is controlled by device controller, the HONGGUANG sent by light dynamical system or near infrared light lesions position, excitated blue composite Nano liposome produces singlet oxygen, and rapid temperature increases is to certain temperature, and kill tumor cell, reach therapeutic purposes; Simultaneously, infrared temperature detecting module carries out Real-Time Monitoring to the temperature of target area, and feeds back to device controller and main control computer, for optical dynamic therapy module output provides reference data, make to control optical dynamic therapy module output better, improve therapeutic effect.
The beneficial effects of the utility model:
(1) this utility model adopts visual nano target technology, utilize nanoparticle automatic target to tumor tissues, blood-oxygen functional Enhanced Imaging can be realized, optical dynamic therapy can be produced again kill tumor tissues and remove remaining zero tumor cell under infrared ray action, reduce and omit probability, improve Clinics and Practices effect.
(2) this utility model carries out acquisition process to the tumor image of tracer radiography, clearly shows the wheel hub of tumor and region and border, for the operation treatment of healthcare givers provides effective guiding.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Detailed description of the invention
Below in conjunction with drawings and Examples, this utility model is further illustrated, but protection domain of the present utility model is not only confined to following examples.
Embodiment 1
A kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, comprises main control computer, device controller, infrared imaging module, infrared ray generation module and optical dynamic therapy module; Described main control computer is connected by universal serial bus with device controller; Described device controller respectively with optical dynamic therapy module, infrared ray generation model calling; Described infrared imaging module is connected with main control computer by bus.
Described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively.Described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively.Described optical dynamic therapy module is provided with the drive circuit and optical dynamic therapy probe that connect successively.
The operation principle of the present embodiment:
Infrared ray generation module, under the control of device controller, produces the infrared drive singal of characteristic frequency and pulsewidth, drives infrared emitting probe to produce the infrared light of certain power and specific wavelength, and is irradiated to treatment target corresponding site, then, the blood flow of infrared imaging module acquires treatment target specific region, blood oxygen and the tumor tissues image be colored, then feed back to main control computer and carry out treatment and analysis, again according to the analyzing and diagnosing result of main control computer, HONGGUANG or the near infrared light that optical dynamic therapy module produces specific wavelength and power is controlled by device controller, the HONGGUANG sent by light dynamical system or near infrared light lesions position, sensitiser absorption in tumor tissues or tumor cell can produce photodynamic reaction (photochemical reaction) and generate active very strong singlet oxygen and (or) free radical after the light energy of this wavelength, singlet oxygen and multiple biomacromolecule generation oxidation reaction, and rapid temperature increases to certain temperature kills tumor cell, realize AT optical dynamic therapy.
Embodiment 2
The present embodiment difference from Example 1 is: described infrared CCD photographic head is provided with infrared fileter.Make gathered image not by the interference of extraneous visible ray, reduce background noise.
Embodiment 3
The present embodiment difference from Example 2 is: described diagnosis and therapy system also comprises infrared temperature detecting module, and described infrared temperature detecting module is connected with device controller.The function of infrared temperature detecting module carries out Real-Time Monitoring to the temperature of target area, and feed back to device controller and main control computer, for optical dynamic therapy module output provides reference data, make the output controlling optical dynamic therapy module better, improve therapeutic effect.
Claims (6)
1. breast tumor blood oxygen nanometer strengthens a functional image Clinics and Practices system, it is characterized in that: main control computer, device controller, infrared imaging module, infrared ray generation module and optical dynamic therapy module; Described main control computer is connected by universal serial bus with device controller; Described device controller respectively with optical dynamic therapy module, infrared ray generation model calling; Described infrared imaging module is connected with main control computer by bus.
2. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system, it is characterized in that: described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively.
3. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system, it is characterized in that: described infrared CCD photographic head is provided with infrared fileter.
4. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system, it is characterized in that: described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively.
5. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system, it is characterized in that: described optical dynamic therapy module is provided with the drive circuit and optical dynamic therapy probe that connect successively.
6. strengthen functional image Clinics and Practices system according to the arbitrary described breast tumor blood oxygen nanometer of claim 1-5, it is characterized in that: described Clinics and Practices system also comprises infrared temperature detecting module, described infrared temperature detecting module is connected with device controller.
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| CN201520894141.2U CN205163039U (en) | 2015-11-11 | 2015-11-11 | Diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106667430A (en) * | 2015-11-11 | 2017-05-17 | 南宁科伦新技术有限公司 | Nano-reinforced functional blood oxygen imaging diagnosing and treating system for breast tumor and application thereof |
| CN111493887A (en) * | 2020-03-30 | 2020-08-07 | 浙江大学 | Handheld tubular biological probe and detection method for detecting activity of organs |
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2015
- 2015-11-11 CN CN201520894141.2U patent/CN205163039U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106667430A (en) * | 2015-11-11 | 2017-05-17 | 南宁科伦新技术有限公司 | Nano-reinforced functional blood oxygen imaging diagnosing and treating system for breast tumor and application thereof |
| CN111493887A (en) * | 2020-03-30 | 2020-08-07 | 浙江大学 | Handheld tubular biological probe and detection method for detecting activity of organs |
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Effective date of registration: 20210407 Address after: No. 501-5c30, 5th floor, building 1, electronic industrial park, Gaoke Road, Nanning high tech Zone, No. 8, Gaoke Road, Nanning City, Guangxi Zhuang Autonomous Region, 530000 Patentee after: Guangxi Dingyao chaohang Biomedical Technology Co.,Ltd. Address before: 530007 No. 98 Daling Road, the Guangxi Zhuang Autonomous Region, Nanning Patentee before: NANNING KELUN NEW TECHNOLOGY Co.,Ltd. |