CN104665772A - All-optical fiber type device for detecting and treating superficial cancer cells - Google Patents
All-optical fiber type device for detecting and treating superficial cancer cells Download PDFInfo
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- CN104665772A CN104665772A CN201510077495.2A CN201510077495A CN104665772A CN 104665772 A CN104665772 A CN 104665772A CN 201510077495 A CN201510077495 A CN 201510077495A CN 104665772 A CN104665772 A CN 104665772A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0636—Irradiating the whole body
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Abstract
The invention relates to an all-optical fiber type device for detecting and treating superficial cancer cells. The all-optical fiber type device comprises three parts, i.e., a removable optical fiber type laser generator, a detecting and treating device and a record and analysis system, wherein the three parts are connected by optical fibers, the detecting and treating device is in a round guide rail shape, the round guide rail shape is fixedly provided with a terahertz generating module and a terahertz detecting module, and a detected human body is positioned in the round guide rail shape; laser light generated by the optical fiber type laser generator can be conducted by the optical fibers, a part of light can reach the terahertz generating module through a delay line, the other part of light can reach the terahertz detecting module through an attenuator and a polarizer, and the optical lengths of two light beams are enabled to be equal by regulating the delay line; the terahertz generating module is used for outputting and emitting parallel light, and the parallel light are used for irradiating the detected human body; terahertz waves reflected back by the human body can enter the terahertz detecting module; the terahertz waves can be output to the record and analysis system by the terahertz detecting module. According to the all-optical fiber type device disclosed by the invention, spectrum analysis on organ tissues of the human body can be carried out through a terahertz technology, and the all-optical fiber type device is in an all-optical fiber type and is convenient to move.
Description
Technical field
The present invention relates to a kind of cancerous cell checkout gear, particularly the device of the shallow table cancerous cell of a kind of all-fiber formula test-and-treat.
Background technology
Modern medical techniques depends on CT(computer x line layer radiography for the detection of cancerous cell) and MRI(nuclear magnetic resonance, NMR), but these methods still have a lot of defect.The CT technology to analyze time is long, for less focus owing to there is partial volume effect, easily fails to pinpoint a disease in diagnosis.And the long-time CT that irradiates easily brings out malignant tumor and leukemia, to patient health, there is infringement to a certain extent.For MRI technology, although its detection range is wide, precision is higher, and imaging time is long, and its imaging capability for osseous tissue is poor, and the patient containing metallics for intracorporeal organ cannot check especially, involves great expense and also allows ordinary consumer hang back.In addition, above-mentioned two kinds of methods cannot detect the circulating tumor cell (CTC) that in blood, content is extremely rare, because 1 CTC just can be found in approximately every 1,000,000,000 normal plasma cells, therefore want effectively to detect CTC and still have difficulty to a certain extent, need extremely responsive detection means.
For above-mentioned situation, researcher's proposition THz wave is had to detect tumor cell and utilize THz wave irradiation treatment tumor cell in the world.Terahertz (THz) ripple refers to frequency at 0.1 ~ 10 THz(wavelength at 30 μm ~ 3 mm) interval Far infrared electric magnetic radiation, its wave band, between microwave and infrared light, is by the special area of electronics to photonic propulsion transition on electromagnetic spectrum.Specifically, the macromole vibration of a lot of biological substance and rotational energy level spectrum are also in terahertz wave band, and the characteristic absorption spectrum of material to THz ripple can be utilized to carry out the slight change of analysis of material composition and attribute thereof.
As for the potential treatment of oncocyte, mainly contain two kinds of modes: one is that THz radiation makes biological tissue's temperature raise and indirectly kill and wound cancerous cell.In skin model, Kristensen has confirmed that 1THz continuous wave can make local skin heat up 5 degree, enough plays lethal effect to cancerous cell.Two is biological effects that the nonlinear resonance of Non-ionizing radiation produces, and THz is main react with hydrogen bond, and the intramolecules vibration of low frequency also can cause protein conformation (each protein molecule itself is space structure specifically) to change.Cause nonlinear resonance by the THz exposure of little amplitude, interference DNA transcribes and protein synthesis, thus the change of inducible gene expression.From the above results, THz has the disintegrate or enhancing medicine that promote cancerous cell to the effect of cancerous cell.
But, it is all free space that current THz detects biological sample device, can only be applicable to the test in laboratory of small sample, can not arbitrarily movement, be not suitable for clinical medicine test-and-treat, do not have a kind of can effectively detect and treat shallow table cancerous cell in real time again can the device of convenient movement.
Summary of the invention
The present invention be directed to current THz and detect the problem that biological sample device is not suitable for clinical medicine test-and-treat, propose the device of the shallow table cancerous cell of a kind of all-fiber formula test-and-treat, by Terahertz Technology, spectrum analysis is carried out to human organ tissue, judge whether organ-tissue has cancerous cell exist and judge cancerous cell character, and can utilize that Terahertz light-wave irradiation is fixed a point to cancerous cell, localization and qualitative treatment.In addition, this device is all-fiber formula, convenient mobile, and due to the characteristic of optical fiber softness, the adaptability of device is improved.
Technical scheme of the present invention is: the device of the shallow table cancerous cell of a kind of all-fiber formula test-and-treat, comprises moveable three parts, an optical fiber type laser generator, and two detect therapy equipment, three record analysis systems, by Fiber connection between three parts,
Detecting therapy equipment is a circular guideway shape, and circular guideway shape is fixed with Terahertz generation module and terahertz detection module, human body is positioned at circular guideway shape;
The laser produced by optical fiber laser, via fiber optic conduction, is divided into two parts by beam splitter, Part I light L
1the Terahertz generation module detected in therapy equipment is arrived, Part II light L via delay line
2then pass through the terahertz detection module of attenuator and polariser arrival detection therapy equipment successively, adjustment delay line changes the optical path difference of two-way light beam, by detecting the electric field wave character of the interaction record THz wave of light and THz wave;
Terahertz generation module exports directional light and launches, and enters circular guideway inside, is irradiated in human body; The THz wave reflected via human body enters terahertz detection module;
Terahertz detection module outputs to record analysis system.
Described Terahertz generation module comprises three parts successively, one frequency-doubling crystal, two Terahertz generating meanss, three Terahertz lens, three parts are successively on the same axis, axis crosses the center of circle of circular guideway, light in optical fiber to reach the condition that can produce Terahertz light wave, then enters Terahertz generating means after frequency-doubling crystal frequency frequency multiplication, produces Terahertz light wave, Terahertz light wave is that radiant type outwards sends, and becomes directional light launch by Terahertz lens.
Described terahertz detection module is made up of two parts: Terahertz lens, two terahertz light photoconductive detectors, these two parts successively on the same axis, axis crosses the center of circle of circular guideway, the THz wave that human body reflects by Terahertz lens focus on terahertz light photoconductive detector, optical fiber laser produce light L
2terahertz light photoconductive detector is directly entered by attenuator and polariser.
Described frequency-doubling crystal selects bbo crystal, any one in lbo crystal or ktp crystal.
Described delay line is any one of surface acoustic wave delay line, charge-coupled image sensor delay line, coaxial cable delay line or magnetic static wave delay line.
Described polariser is slice component type fibre optic polarizer.
Described Terahertz lens are High Resistivity Si lens.
Beneficial effect of the present invention is: the device of the shallow table cancerous cell of all-fiber formula test-and-treat of the present invention, is a kind of diagnostic area shallow table cancerous cell Clinics and Practices device large, simple to operate; It is a kind of device that can carry out immunotherapy targeted autoantibody according to the molecular characterization of cancerous cell, biomolecule overall structure and its be the important micro-foundation that THz technology is applied to biological study at the high coherence of THz band spectrum character, biomolecule is to the response of THz radiation mainly from the collective vibration pattern that macromole distributing pattern determines, this collective vibration pattern reflects the overall structure information of molecule; Therefore the therapeutical effect of THz to tumor mainly contains two aspects, and one is that THz radiation makes biological tissue temperature raise and direct killing tumor cell, and two is biological effects that the nonlinear resonance of Non-ionizing radiation produces; Compared to traditional tumor cell detection mode, such as CT and nuclear magnetic resonance, NMR etc., its radiation produced easily causes the pathological changes of focus, and conditions of patients is worsened.But use tera-hertz spectra technology for detection but can reduce the infringement to human body greatly.This is because THz emittance is lower, and can not directly destroy chemical bond or cause electronic switch, thus little to human injury, safety be high.Because Terahertz wave frequency is very high and pulse very short (picosecond magnitude), so it has very high spatial resolution temporal resolution, therefore compared to the image that conventional equipment shows, there is higher quality by THz wave imaging, thus use tera-hertz spectra technology for detection to be not easy generation and fail to pinpoint a disease in diagnosis phenomenon.Present invention employs standing posture and horizontal two sets of plan and equipment, carry out brain diagnosis and systemic diagnostic respectively.
Accompanying drawing explanation
Fig. 1 is the apparatus structure schematic diagram that the present invention realizes the shallow table cancerous cell of a kind of all-fiber formula test-and-treat;
Fig. 2 is Terahertz generation module of the present invention and terahertz detection module diagram;
Fig. 3 is that the present invention detects therapy equipment vertical unit schematic diagram;
Fig. 4 is that the present invention detects therapy equipment horizontal type device schematic diagram.
Detailed description of the invention
Realize the apparatus structure schematic diagram of the shallow table cancerous cell of a kind of all-fiber formula test-and-treat as shown in Figure 1, device is mainly divided into three parts, optical fiber type laser generator 1 respectively, detect therapy equipment 6 and record analysis system 14, by Fiber connection between three parts, convenient mobile, little by ectocine, easy to maintenance time saving and energy saving.
The laser produced by optical fiber laser 1, via fiber optic conduction, is divided into two parts by beam splitter 2, Part I light L
1(detection light) arrives via delay line 5 and detects therapy equipment 6, Part II light L
2then arrived the Part II detection therapy equipment 6 of device by attenuator 3 and polariser 4, wherein delay line 5 is the optical path differences in order to change between detection light and terahertz light, thus records the waveform of the Terahertz of different optical path difference.
The Part II of device detects therapy equipment 6, main detection and the treatment being used as shallow table cancerous cell.Circular guideway 9 is fixed with Terahertz generation module 7 and terahertz detection module 8.Circular guideway 9 can guarantee the relative position of these two modules in same plane and easily adjusting module all the time when device moves, convenient collection of irradiating and reflecting spectral line data to the shallow table cancerous tissue of diverse location.The Terahertz can being measured human body a part by the angle changed between module 7 and module 8 reflects spectral line, facilitates post analysis and judgement.
The structural representation of Terahertz generation module and terahertz detection module as shown in Figure 2.Terahertz generation module 7 is made up of three parts successively: frequency-doubling crystal 10, Terahertz generating means 11 and Terahertz lens 13-1, and successively on the same axis, axis crosses the center of circle of circular guideway 9 to three parts.Wherein, frequency-doubling crystal 10 is used as to carry out frequency frequency multiplication to reach the condition that can produce Terahertz light wave to the light in optical fiber, such as, the light of 1550 nm in optical fiber can be become the pumping light of 780 nm.Terahertz generating means 11 is placed below at frequency-doubling crystal 10, be used for producing THz wave, the Terahertz light wave produced by generating means is that radiant type outwards sends, and launches by becoming directional light after Terahertz lens 13-1, enter circular guideway inside, be irradiated in human body.
Terahertz detection module 8 is made up of two parts: Terahertz lens 13-2 and terahertz light photoconductive detector 12, and successively on the same axis, axis crosses the center of circle of circular guideway 9 to these two parts.First the THz wave reflected via human body focuses on terahertz light photoconductive detector 12 by Terahertz lens 13-2, and another bundle detection phot-luminescence photoconductive detector (is from Part I light L
1come) in free carrier, Terahertz electric field impels carrier moving to produce as deflecting electric field to be proportional to the electric current of terahertz pulse electric field instantaneous value.By changing the time delay (terahertz light, from 3,4,7, reflexes to 8, and detection light is from 5 to 8, and two-beam converges inside 8) between detection light and terahertz light, whole Terahertz electric field situation over time can be obtained, i.e. the reflectance spectrum of Terahertz.Calculate absorbance or reflectance by record analysis system 14 again, and draw out corresponding spectral line, and compare with the data in data base, to judge type and the character of cancerous tissue, the last diagnostic for doctor provides solid Data support.
Described frequency-doubling crystal 10 can be bbo crystal, lbo crystal or ktp crystal.
Described delay line 5 can be surface acoustic wave (ASW) delay line, charge-coupled device (CCD) delay line, coaxial cable delay line or magnetic static wave (MSW) delay line.
Described polariser 4 can be slice component type fibre optic polarizer.
Described Terahertz lens 13 material can be TPX, High Resistivity Si lens.
In addition, detect therapy equipment 6 and can provide vertical and horizontal two kinds of rack constructions, respectively as shown in Figure 3 and Figure 4, doctor according to the different choice detection mode of conditions of patients, can improve detection efficiency, for patient provides convenient.Described device, except the shallow table cancerous cell of detection, also can utilize THz wave to irradiate the characteristic changing cancerous cell, treat shallow table cancerous cell.
Claims (7)
1. a device for the shallow table cancerous cell of all-fiber formula test-and-treat, is characterized in that, comprises moveable three parts, an optical fiber type laser generator, and two detect therapy equipment, three record analysis systems, by Fiber connection between three parts,
Detecting therapy equipment is a circular guideway shape, and circular guideway shape is fixed with Terahertz generation module and terahertz detection module, human body is positioned at circular guideway shape;
The laser produced by optical fiber laser, via fiber optic conduction, is divided into two parts by beam splitter, Part I light L
1the Terahertz generation module detected in therapy equipment is arrived, Part II light L via delay line
2then pass through the terahertz detection module of attenuator and polariser arrival detection therapy equipment successively, adjustment delay line changes the optical path difference of two-way light beam, by detecting the electric field wave character of the interaction record THz wave of light and THz wave;
Terahertz generation module exports directional light and launches, and enters circular guideway inside, is irradiated in human body; The THz wave reflected via human body enters terahertz detection module;
Terahertz detection module outputs to record analysis system.
2. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 1, it is characterized in that, described Terahertz generation module comprises three parts successively, one frequency-doubling crystal, two Terahertz generating meanss, three Terahertz lens, three parts successively on the same axis, axis crosses the center of circle of circular guideway, light in optical fiber after frequency-doubling crystal frequency frequency multiplication to reach the condition that can produce Terahertz light wave, enter Terahertz generating means again, produce Terahertz light wave, Terahertz light wave is that radiant type outwards sends, become directional light by Terahertz lens to launch.
3. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 1 or 2, it is characterized in that, described terahertz detection module is made up of two parts: Terahertz lens, two terahertz light photoconductive detectors, these two parts successively on the same axis, axis crosses the center of circle of circular guideway, the THz wave that human body reflects by Terahertz lens focus on terahertz light photoconductive detector, optical fiber laser produce light L
2terahertz light photoconductive detector is directly entered by attenuator and polariser.
4. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 2, it is characterized in that, described frequency-doubling crystal selects bbo crystal, any one in lbo crystal or ktp crystal.
5. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 1, is characterized in that, described delay line is any one of surface acoustic wave delay line, charge-coupled image sensor delay line, coaxial cable delay line or magnetic static wave delay line.
6. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 1, it is characterized in that, described polariser is slice component type fibre optic polarizer.
7. the device of the shallow table cancerous cell of all-fiber formula test-and-treat according to claim 1, it is characterized in that, described Terahertz lens are High Resistivity Si lens.
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Cited By (6)
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| CN105910707A (en) * | 2016-06-16 | 2016-08-31 | 中国工程物理研究院流体物理研究所 | All-fiber time domain terahertz spectroscopy rapid scanning method based on optical fiber stretcher |
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| CN106599594A (en) * | 2016-12-22 | 2017-04-26 | 白云绮 | Human digital model based on terahertz quantum wave information and disease-diagnosing and treating system |
| CN110338792A (en) * | 2019-08-22 | 2019-10-18 | 华中科技大学同济医学院附属同济医院 | Ovarian epithelium malignant tumour detection device |
| CN113471797A (en) * | 2021-05-14 | 2021-10-01 | 中国人民解放军空军军医大学 | Optical fiber laser integrating pathological detection and laser treatment functions |
| CN118319647A (en) * | 2024-05-08 | 2024-07-12 | 零平衡健康产业(常州)有限公司 | Multifunctional biological energy sleep health maintenance cabin system |
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| CN106248615A (en) * | 2015-06-05 | 2016-12-21 | 中国科学院苏州纳米技术与纳米仿生研究所 | A kind of THz wave analyzer |
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| CN106599594A (en) * | 2016-12-22 | 2017-04-26 | 白云绮 | Human digital model based on terahertz quantum wave information and disease-diagnosing and treating system |
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| CN110338792A (en) * | 2019-08-22 | 2019-10-18 | 华中科技大学同济医学院附属同济医院 | Ovarian epithelium malignant tumour detection device |
| CN113471797A (en) * | 2021-05-14 | 2021-10-01 | 中国人民解放军空军军医大学 | Optical fiber laser integrating pathological detection and laser treatment functions |
| CN118319647A (en) * | 2024-05-08 | 2024-07-12 | 零平衡健康产业(常州)有限公司 | Multifunctional biological energy sleep health maintenance cabin system |
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