CN108379601A - A kind of applications of the Au@ZIF-8 of glutathione triggering on preparing photo-acoustic detection tumor reagent - Google Patents
A kind of applications of the Au@ZIF-8 of glutathione triggering on preparing photo-acoustic detection tumor reagent Download PDFInfo
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- CN108379601A CN108379601A CN201810162060.1A CN201810162060A CN108379601A CN 108379601 A CN108379601 A CN 108379601A CN 201810162060 A CN201810162060 A CN 201810162060A CN 108379601 A CN108379601 A CN 108379601A
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- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title claims abstract description 52
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 32
- 229960003180 glutathione Drugs 0.000 title claims abstract description 26
- 238000001514 detection method Methods 0.000 title claims abstract description 16
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 15
- 108010024636 Glutathione Proteins 0.000 title claims abstract description 7
- 238000005253 cladding Methods 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 54
- 239000013154 zeolitic imidazolate framework-8 Substances 0.000 claims description 7
- MFLKDEMTKSVIBK-UHFFFAOYSA-N zinc;2-methylimidazol-3-ide Chemical compound [Zn+2].CC1=NC=C[N-]1.CC1=NC=C[N-]1 MFLKDEMTKSVIBK-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- LXBGSDVWAMZHDD-UHFFFAOYSA-N 2-methyl-1h-imidazole Chemical compound CC1=NC=CN1 LXBGSDVWAMZHDD-UHFFFAOYSA-N 0.000 claims description 3
- 150000002460 imidazoles Chemical class 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 239000010931 gold Substances 0.000 abstract description 48
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract description 6
- 229910052737 gold Inorganic materials 0.000 abstract description 6
- 239000002077 nanosphere Substances 0.000 abstract description 4
- 230000002776 aggregation Effects 0.000 abstract description 3
- 238000004220 aggregation Methods 0.000 abstract description 3
- 230000004044 response Effects 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 230000009102 absorption Effects 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 4
- 238000009835 boiling Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 235000011083 sodium citrates Nutrition 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical class [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000013007 heat curing Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910004042 HAuCl4 Inorganic materials 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 235000019647 acidic taste Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012621 metal-organic framework Substances 0.000 description 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N methylimidazole Natural products CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000007626 photothermal therapy Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019263 trisodium citrate Nutrition 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention relates to a kind of applications of the Au@ZIF 8 of glutathione triggering on preparing photo-acoustic detection tumor reagent, the Au@ZIF 8 are made of the ZIF 8 of Au NPs and cladding Au NPs.Compared with prior art, the present invention is responded using Au@ZIF 8 and GSH, make gold nanosphere be released to be coordinated to form aggregation with GSH, to be allowed to have strong absorption in near-infrared, it can be applied to tumour photo-acoustic detection, entire material preparation is simple, and response sensitivity is high, and it is high that signal-to-noise ratio is imaged at tumour.
Description
Technical field
The present invention relates to technical field of nano material, are being prepared more particularly, to a kind of Au@ZIF-8 of glutathione triggering
Application on photo-acoustic detection tumor reagent.
Background technology
Malignant tumour is had become and seriously endangers mankind's life one of the main reason for causing whole world human death at present
Life health, a kind of major disease for restricting socio-economic development.Near infrared light heat cure is the hot spot of current cancer therapies research,
Compared with traditional treatment mode, near-infrared diagnosis and treatment integration has many advantages, such as Noninvasive, Small side effects.But current skill
Art is still faced with lot of challenges for the treatment of tumour, being accurately positioned, early diagnose, monitor in real time and controlling such as tumor focus
Treat the raising etc. of validity.The near-infrared photo-thermal that near infrared light heat cure technology and diagnosing tumor technology are organically integrated
Diagnosis and treatment integration can be very good to solve these problems.The integration of near-infrared photo-thermal diagnosis both can carry out visualization inspection to tumour
It surveys, and can realize the individualized treatment for tumour difference with the photo-thermal therapy effect of dynamic evaluation tumour.And near-infrared photo-thermal
The key of diagnosis and treatment integrated technique development is to develop near-infrared photo-thermal diagnosis reagent.Therefore, it develops a kind of efficiently applicable
Near-infrared photo-thermal diagnosis reagent has especially important practical significance.
Invention content
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide a kind of glutathione to trigger
Au@ZIF-8 prepare photo-acoustic detection tumor reagent on application.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of applications of the Au@ZIF-8 of glutathione triggering on preparing photo-acoustic detection tumor reagent, the Au@ZIF-8
It is made of the ZIF-8 of Au NPs and cladding Au NPs.
Au@ZIF-8 employed in the present invention may be used existing method and be made.Preferably, the Au@ZIF-8
It is made by the following method：
(1)：Prepare Au NPs；
(2)：Au NPs are added in PVP, stirs, is washed with methanol, centrifuges, is scattered in spare in methanol；
(3)：Zn (NO are added into Au NPs methanol solutions obtained in step (2)3)2·6H2The methanol solution and 2- of O
The methanol solution of methylimidazole stands to get to purpose product.
It is furthermore preferred that in step (1), the average grain diameter of the Au NPs is 25nm.Au NPs may be used existing
Reduction of sodium citrate method synthesizes.
It is furthermore preferred that Zn (NO in step (3)3)2·6H2The molar ratio of O and 2-methylimidazole is 1:1.
It is furthermore preferred that the time stood in step (3) is for 24 hours.
It is furthermore preferred that the photo-acoustic detection tumor reagent is the reagent of photo-acoustic detection breast cancer tumour.
The photoacoustic imaging group of photo-acoustic detection tumor reagent prepared by the present invention is divided into Au ZIF-8, utilizes photothermal conversion efficiency
There is the effect absorbed by force in near-infrared after gold nanoparticle aggregation made of high noble metal gold, meanwhile, because of tumour micro-loop
The features such as border is complicated, integrated environment pH slant acidities, and the expression of GSH wherein is far above normal structure, the present invention is using tool
There are the ZIF-8 cladding Au NPs that GSH is responded.In this way, when Au@ZIF-8 are after injecting tumour, the GSH responses due to ZIF-8 and pH
Response, MOF structural separations expose gold nanosphere, while gold nanosphere is assembled under the coordination of GSH, improve material light
Thermal conversion efficiency causes the tumour treatment effect of material to significantly improve.In photo-acoustic detection tumor reagent prepared by the present invention, in addition to
Outside Au@ZIF-8, pharmaceutically acceptable targeting vector etc. can also be coordinated as needed.
Compared with prior art, the present invention is responded using Au@ZIF-8 and GSH, and gold nanosphere is made to be released and GSH
Coordination forms aggregation, to be allowed to have strong absorption in near-infrared, can be applied to tumour photo-acoustic detection.Material preparation is simple, rings
High sensitivity is answered, it is high that signal-to-noise ratio is imaged at tumour.
Description of the drawings
Fig. 1 is the TEM figures of the different resolution for the Au@ZIF-8 that embodiment 1 is prepared；
Fig. 2 is the SEM figures of the different resolution for the Au@ZIF-8 that embodiment 1 is prepared；
Fig. 3 is that solution UV absorptions of the Au@ZIF-8 that are prepared of embodiment 1 before and after GSH is added changes；
Fig. 4 is that solution optoacoustics of the Au@ZIF-8 that are prepared of embodiment 1 before and after GSH is added is tested；
Fig. 5 and Fig. 6 is then the Au@ZIF-8 trackings that photoacoustic signal changes in vivo tumor that embodiment 1 is prepared.
Specific implementation mode
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment 1
(1) it takes 85mg sodium citrates in 150mL secondary waters, is heated to boiling, 1mL 25mM HAuCl are added4, until molten
Liquid takes on a red color, and after cooling, take 55mL solution addition 53mL secondary waters and 2mL 60mM sodium citrates to be heated to boiling, 1mL is added
HAuCl490 DEG C are cooled to, 1mL HAuCl are added after 30min4, 1mL HAuCl are added after 30min4, react 30min and obtain
The Au NPs of 25nm.25mg/mL 20mL PVP are added after cooling, 400rpm is stirred for 24 hours.Centrifugation is washed three times with methanol, dispersion
In 5mL methanol；
(2) take above-mentioned solution 1mL that 5mL 25mM Zn (NO are added3)2·6H2The methanol solution of O and the 2- first of 5mL 25mM
The methanol solution of base imidazoles is stood for 24 hours, synthesis Au@ZIF-8.
The TEM figures and SEM figures of Au@ZIF-8 obtained by the present embodiment is as depicted in figs. 1 and 2 respectively, by that can be seen in figure
Go out, has finally been successfully prepared the nano material of ZIF-8 claddings Au really.
Embodiment 2
(1) 15mg HAuCl are taken4It in 150mL secondary waters, is heated to boiling, 1% trisodium citrates of 4.5mL is added, stir
Reflux 20min is mixed, red solution is generated.25mg/mL 20mL PVP are added after cooling, 400rpm is stirred for 24 hours.Centrifugation, uses methanol
It washes three times, is dispersed in 5mL methanol；
(2) take above-mentioned solution 1mL that 3mL 25mM Zn (NO are added3)2·6H2The methanol solution of O and the 2- first of 3mL 25mM
The methanol solution of base imidazoles is stood for 24 hours, synthesis Au@ZIF-8.
Embodiment 3
It takes Au@ZIF-8 made from appropriate embodiment 1 to be scattered in deionized water, detects its ultraviolet absorption curve, then,
The 20mM GSH of equivalent are added, detect the variation of the ultraviolet absorption curve of material again.
Fig. 3 is then solution UV absorption variation diagrams of the Au@ZIF-8 before and after GSH is added, it can be seen from the figure that Au@
There is ZIF-8 extraordinary GSH to respond effect, which is easy to be degraded after encountering GSH, and then generate with very strong
Near infrared absorption effect.Embodiment 4
It takes Au@ZIF-8 made from appropriate embodiment 1 to be scattered in deionized water, detects it and detect its photoacoustic signal, with
Afterwards, the 20mM GSH of equivalent are added, detect the photoacoustic signal of material again.
After being triggered by GSH due to Au@ZIF-8, there is good near infrared absorption effect.Fig. 4 is then that Au@ZIF-8 are adding
Enter the solution optoacoustic test before and after GSH, it can be seen from the figure that before Au@ZIF-8 are triggered by GSH, does not have optoacoustic image and imitate
Fruit, and then there is extraordinary optoacoustic image effect after triggering.
Embodiment 5
Establish breast cancer tumour model with mouse, diameter 5mm grown in tumour, it is ensured that in the case of not forming a scab into
Row optoacoustic is tested, and after importing spectrum, is carried out mouse blank scanning, is then injected the Au@ZIF- prepared by a certain amount of embodiment 1
8 materials carry out live body photo-acoustic detection, variation of the tracking photoacoustic signal in 5min, 30min, 1h, 3h, 12h.
Fig. 5 and Fig. 6 then shows the Au@ZIF-8 trackings that photoacoustic signal changes in vivo tumor, can from figure
Go out, after Au@ZIF-8 injection tumours, is triggered by GSH, show extraordinary tumor imaging effect.
The above description of the embodiments is intended to facilitate ordinary skill in the art to understand and use the invention.
Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general
Principle is applied in other embodiment without having to go through creative labor.Therefore, the present invention is not limited to the above embodiments, ability
Field technique personnel announcement according to the present invention, improvement and modification made without departing from the scope of the present invention all should be the present invention's
Within protection domain.
Claims (6)
1. a kind of applications of Au@ZIF-8 of glutathione triggering on preparing photo-acoustic detection tumor reagent, which is characterized in that institute
Au@ZIF-8 are stated to be made of the ZIF-8 of Au NPs and cladding Au NPs.
2. application according to claim 1, which is characterized in that the Au@ZIF-8 are made by the following method：
(1)：Prepare Au NPs；
(2)：Au NPs are added in PVP, stirs, is washed with methanol, centrifuges, is scattered in spare in methanol；
(3)：Zn (NO are added into Au NPs methanol solutions obtained in step (2)3)2·6H2The methanol solution and 2- methyl of O
The methanol solution of imidazoles stands to get to purpose product.
3. application according to claim 2, which is characterized in that in step (1), the average grain diameter of the Au NPs is
25nm。
4. application according to claim 2, which is characterized in that Zn (NO in step (3)3)2·6H2O and 2-methylimidazole
Molar ratio is 1:1.
5. application according to claim 2, which is characterized in that the time stood in step (3) is for 24 hours.
6. application according to claim 2, which is characterized in that the photo-acoustic detection tumor reagent is photo-acoustic detection mammary gland
The reagent of tumor.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109663135A (en) * | 2018-11-21 | 2019-04-23 | 上海师范大学 | ZIF-8 coats ferriferrous oxide nano-particle material and its preparation method and application |
| CN110125434A (en) * | 2019-05-14 | 2019-08-16 | 东南大学 | A kind of preparation method of photo-thermal gold nano-material |
| CN110404071A (en) * | 2019-08-23 | 2019-11-05 | 上海师范大学 | A kind of tumour diagnosis and treatment reagent of glutathione triggering |
| CN115260508A (en) * | 2022-06-06 | 2022-11-01 | 西北工业大学 | Preparation method of ZIF-8 and glutathione responsive hollow microspheres |
| CN115282290A (en) * | 2022-07-20 | 2022-11-04 | 武汉理工大学 | pH-responsive Au @ ZIF-8 water phase preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160250357A1 (en) * | 2015-02-26 | 2016-09-01 | George Mason University | Mechanisms involved in the formation of biocompatible lipid polymeric patchy particles |
| CN107137060A (en) * | 2017-04-14 | 2017-09-08 | 同济大学 | A kind of gold nanosphere/chicken egg white composite Nano optoacoustic probe being easily metabolized and its preparation |
| CN107648606A (en) * | 2017-11-09 | 2018-02-02 | 上海纳米技术及应用国家工程研究中心有限公司 | Collect chemotherapy and the preparation method of thermotherapy integrated nuclear shell nanometer material and products thereof and application |
-
2018
- 2018-02-26 CN CN201810162060.1A patent/CN108379601A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160250357A1 (en) * | 2015-02-26 | 2016-09-01 | George Mason University | Mechanisms involved in the formation of biocompatible lipid polymeric patchy particles |
| CN107137060A (en) * | 2017-04-14 | 2017-09-08 | 同济大学 | A kind of gold nanosphere/chicken egg white composite Nano optoacoustic probe being easily metabolized and its preparation |
| CN107648606A (en) * | 2017-11-09 | 2018-02-02 | 上海纳米技术及应用国家工程研究中心有限公司 | Collect chemotherapy and the preparation method of thermotherapy integrated nuclear shell nanometer material and products thereof and application |
Non-Patent Citations (7)
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109663135A (en) * | 2018-11-21 | 2019-04-23 | 上海师范大学 | ZIF-8 coats ferriferrous oxide nano-particle material and its preparation method and application |
| CN109663135B (en) * | 2018-11-21 | 2021-10-22 | 上海师范大学 | ZIF-8 coated ferroferric oxide nanoparticle material and preparation method and application thereof |
| CN110125434A (en) * | 2019-05-14 | 2019-08-16 | 东南大学 | A kind of preparation method of photo-thermal gold nano-material |
| CN110125434B (en) * | 2019-05-14 | 2022-07-29 | 东南大学 | Preparation method of photo-thermal gold nano material |
| CN110404071A (en) * | 2019-08-23 | 2019-11-05 | 上海师范大学 | A kind of tumour diagnosis and treatment reagent of glutathione triggering |
| CN115260508A (en) * | 2022-06-06 | 2022-11-01 | 西北工业大学 | Preparation method of ZIF-8 and glutathione responsive hollow microspheres |
| CN115260508B (en) * | 2022-06-06 | 2023-09-19 | 西北工业大学 | Preparation method of ZIF-8 and glutathione responsive hollow microspheres |
| CN115282290A (en) * | 2022-07-20 | 2022-11-04 | 武汉理工大学 | pH-responsive Au @ ZIF-8 water phase preparation method |
| CN115282290B (en) * | 2022-07-20 | 2023-08-15 | 武汉理工大学 | PH response Au@ZIF-8 aqueous phase preparation method |
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Application publication date: 20180810 |