CN105435377A - Radiotherapy dosage measuring device and measuring method thereof - Google Patents

Radiotherapy dosage measuring device and measuring method thereof Download PDF

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Publication number
CN105435377A
CN105435377A CN201510863610.9A CN201510863610A CN105435377A CN 105435377 A CN105435377 A CN 105435377A CN 201510863610 A CN201510863610 A CN 201510863610A CN 105435377 A CN105435377 A CN 105435377A
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detector
radiotherapy
emccd
measuring device
angle
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CN105435377B (en
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汤晓斌
舒迪昀
龚频
耿长冉
陈达
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Nanjing University of Aeronautics and Astronautics
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Nanjing University of Aeronautics and Astronautics
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Abstract

The invention discloses a radiotherapy dosage measuring device and a measuring method thereof, and belongs to the radiotherapy field. The radiotherapy dosage measuring device includes 3 wide-angle lenses, 3 EMCCD detectors, a detector rotation device, a multichannel data registration and collection module and a computer processing unit. Based on the Cherenkov optical intensity data generated during a multi-angle acquisition radiotherapy process, the radiotherapy dosage measuring device and the measuring method thereof can obtain Cherenkov optical intensity distribution of a tumour and the surrounding area of the tumour through optical tomography reconstruction, and can finally obtain radiotherapy dosage distribution according to the quantitative relation between the Cherenkov optical intensity and the dosage deposition. The radiotherapy dosage measuring device and the measuring method thereof have the advantages of being able to acquire three dimensional dosage distribution, being high in real time online property and being simple in measurement, and can effectively guarantee the curative effect of radiotherapy and radiation safety for a patient.

Description

A kind of radiotherapy dose measuring device and measuring method
Technical field
The invention belongs to field of radiation therapy, being specifically related to a kind of device and method for measuring radiotherapy radiation dose in real time.
Technical background
In radiation therapy process, the factor such as anatomical structure change, the inaccurate and patient's Set-up errors of radiotherapy apparatus output parameter all will cause Radiotherapy dosimetry inaccurate, thus affects the effect of radiation therapy or cause excessive exposure.Namely No. ICRU24 report pointed out, the departing from of target dose ± 5% just likely makes primary tumor out of control or increase the probability of normal organ complication.The Real-time Measuring Technique of radiotherapy dosage can the actual deviation of authorizing between dosage and intended dose of real-time verification, be convenient to Timeliness coverage plan executive problem and amendment and for follow-up curative effect evaluation, truly accomplish the real-time quality assurance of dosage accuracy, effectively guarantee Radiotherapy and ensure patient irradiation's safety.But the difficulty that in patient body, dose distribution is measured in real time and uncertainty are large, real-time measurement means is still more single and not yet enough " ideal ", is to restrict the bottleneck that radiotherapy further develops always.Therefore, be badly in need of a kind of new equipment of measuring in real time for radiotherapy dosage of development and new method, the real-time measurement of dose distribution in patient body can be realized.
Summary of the invention
Technical problem to be solved by this invention is for prior art defect, and 3-dimensional dose distributes, real-time online is good, measure simple radiotherapy dose measuring device and measuring method to provide one to obtain.
The present invention is for solving the problems of the technologies described above by the following technical solutions:
A kind of radiotherapy dose measuring device, comprises three wide-angle lens, three EMCCD detectors, detector rotary apparatus, multi-channel data registration collection module and computer processing units; Described wide-angle lens is connected with EMCCD detector, and described detector rotary apparatus and EMCCD detector are connected with multi-channel data registration collection module respectively, and multi-channel data registration collection module connects computer processing unit.
Described wide-angle lens is large aperture adjustable focus wide-angle lens.
The spectral response range of described EMCCD detector should with Cherenkov light Spectral matching, the peak quantum efficiency of described EMCCD detector should reach more than 90%, and reading noise should be low as far as possible.
Described EMCCD detector is fixed on detector rotary apparatus, realizes 360 ° of all-directional rotations of detector by rotary apparatus.
Described computer processing unit can control the even parameter of detector rotary apparatus and rotate and fixed point remaining, and space angle information residing for EMCCD detector can be passed to multi-channel data registration collection module by detector rotary apparatus simultaneously.
Space angle information when described multi-channel data registration collection module can receive simultaneously and integrate optical signal data and the EMCCD detector measurement of three EMCCD detectors, and then pass to computer processing unit.
Described computer processing unit have realize background data deduction, optical fault rebuilds and Cherenkov light light distribution is converted to the function of dose distribution.
Present invention also offers the measuring method of radiotherapy dose measuring device, comprise following steps:
1) according to knub position and size, the distributing position of adjustment detector rotary apparatus position, EMCCD detector and wide-angle lens focal length size.
2) before radiation treatment, the measurement parameter according to device in therapeutic process is arranged, and utilizes wide-angle lens to obtain stray radiation background data and the ambient light background data of single angle.
3) in radiation therapy process, the even parameter of computer processing unit control EMCCD detector rotary apparatus rotates and fixed point remaining, space angle information when multi-channel data registration collection module receives simultaneously and integrates optical signal data and the EMCCD detector measurement of three EMCCD detectors, passes to computer processing unit.This information collected is the multi-angle optical signal data of tumor and peripheral region thereof and corresponding space angle information.
4) optical signal data that each angle obtains is deducted stray radiation background data and ambient light background data respectively, obtain the Cherenkov light light intensity data of each angle.
5) utilize the Cherenkov light light intensity data of each angle and corresponding space angle information to carry out optical fault reconstruction, obtain the unit volume Cherenkov light light distribution N(x of tumor and peripheral region thereof, y, z).
6) based on the quantitative ratio relation between Cherenkov light light intensity and dosage deposition, according to unit volume Cherenkov light light distribution N(x, y, z) obtain Dose Distribution in Radiotherapy Treatment D(x, y, z).
Beneficial effect of the present invention is: utilize the Cherenkov light produced in ray and matter interaction process, utilizes multi-angle Cherenkov light light intensity data to rebuild the Cherenkov light light distribution obtaining tumor and peripheral region thereof; Meanwhile, based on the quantitative relationship between Cherenkov light light intensity and dosage deposition, and then the dose distribution in radiation therapy process in patient body can be obtained in real time, to guarantee radiocurable curative effect and to ensure patient irradiation's safety.
Accompanying drawing explanation
Fig. 1 is radiotherapy dose measuring device structural representation of the present invention;
Fig. 2 is the measuring method schematic flow sheet of radiotherapy dose measuring device of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further detail.
As shown in Figure 1, this radiotherapy dose measuring device, comprise detector rotary apparatus 1 and some EMCCD detectors 2 being provided with wide-angle lens 3, detector rotary apparatus 1 is all connected 5 by multi-channel data registration collection module 4 with computer processing unit with each EMCCD detector 2; EMCCD detector 2 is fixed on detector rotary apparatus 1, and detector rotary apparatus 1 controls whole EMCCD detectors 2 around the rotation of 360 °, a certain center.
Described wide-angle lens 3 is large aperture adjustable focus wide-angle lens, according to target area and can jeopardize organ size adjusting focal length.The spectral response range of described EMCCD detector 2 should with Cherenkov light Spectral matching, the peak quantum efficiency of described EMCCD detector 2 should reach more than 90%, and reading noise should be low as far as possible.Described EMCCD detector 2 is fixed on detector rotary apparatus 1, and realize 360 ° of all-directional rotations of detector by rotary apparatus, described detector rotary apparatus 1 is fixed on directly over tumor locus by two support bars.Described computer processing unit 5 can control the even parameter of detector rotary apparatus 1 and rotate and fixed point remaining, space angle information residing for EMCCD detector 2 can be passed to multi-channel data registration collection module 4 simultaneously.
Space angle information when described multi-channel data registration collection module 4 can receive simultaneously and integrate optical signal data and the EMCCD detector measurement of three EMCCD detectors, and then pass to computer processing unit 5.Described computer processing unit 5 have realize background data deduction, optical fault rebuilds and Cherenkov light light distribution is converted to the function of dose distribution.
In radiation therapy process, the optical signal data after integrating after multi-channel data registration collection module 4 processes, is passed to computer processing unit 5 by the multi-angle optical signal detected by described EMCCD detector 2.Optical signal data is deducted stray radiation background data and ambient light background data by described computer processing unit 5, and carry out optical fault reconstruction in conjunction with the space angle information of EMCCD detector 2, the optical tomographic image obtained and original CT anatomical structure figure are carried out registration, obtains the unit volume Cherenkov light light distribution of tumor and peripheral region thereof.According to the quantitative relationship that Cherenkov light light intensity and dosage deposit, finally obtain Dose Distribution in Radiotherapy Treatment.
Fig. 2 is the measuring method schematic flow sheet of radiotherapy dose measuring device of the present invention, and detailed process is:
Step 1) according to knub position and size, adjustment detector rotary apparatus position and wide-angle lens focal length size, the rotation of clinac head when detector rotary apparatus position should take into full account treatment;
Step 2) based on digital equivalent body mould, in conjunction with the beam condition that TPS plan is arranged, Monte Carlo tool kit Geant4 is utilized to calculate Cherenkov light light distribution and the dosage deposition distribution of tumor and peripheral region thereof, the conversion coefficient that acquisition tumor and any position, peripheral region thereof deposit from Cherenkov light light intensity to dosage;
Before radiation treatment, the measurement parameter according to device in therapeutic process is arranged step 3), covers the lens cap of wide-angle lens 3, obtains the stray radiation background data that identical beam condition irradiates lower single angle; Meanwhile, open at lens cap and obtain ambient light background data under non-radiation situation;
Step 4) is in radiation therapy process, control detector rotary apparatus 1 by computer processing unit 5 and carry out multi-angle one-point measurement, space angle information and the optical signal transfer detected are processed to multi-channel data registration collection module 4, data pass to computer processing unit 5 the most at last simultaneously;
The optical signal data deduction stray radiation background data that each angle obtains by step 5) computer processing unit 5 and ambient light background data, and the angle information combining acquisition carries out optical fault reconstruction, the optical tomographic image obtained and original CT anatomical structure figure are carried out registration, obtain the unit volume Cherenkov light light distribution N(x of tumor and peripheral region thereof, y, z);
The conversion coefficient obtained in step 6) integrating step 2, according to unit volume Cherenkov light light distribution N(x, y, z) be converted to Dose Distribution in Radiotherapy Treatment D(x, y, z).
The present embodiment is explained technical solution of the present invention with three EMCCD detectors and three wide-angle lens, can according to actual needs and economic condition increase the number of detector and wide-angle lens, no longer repeat at this.
The above is only the preferred embodiment of the present invention, it should be pointed out that for those skilled in the art, can also make some improvement under the premise without departing from the principles of the invention, and these improvement also should be considered as protection scope of the present invention.

Claims (5)

1. a radiotherapy dose measuring device, it is characterized in that: comprise detector rotary apparatus (1) and some EMCCD detectors (2) being provided with wide-angle lens (3), detector rotary apparatus (1) is all connected with computer processing unit (5) by multi-channel data registration collection module (4) with each EMCCD detector (2); EMCCD detector (2) is fixed on detector rotary apparatus (1), and detector rotary apparatus (1) controls whole EMCCD detectors (2) around a certain central rotation.
2. radiotherapy dose measuring device according to claim 1, is characterized in that: described wide-angle lens (3) is large aperture adjustable focus wide-angle lens.
3. radiotherapy dose measuring device according to claim 1, is characterized in that: the spectral response range of described EMCCD detector (2) should with Cherenkov light Spectral matching, the peak quantum efficiency of described EMCCD detector (2) should be greater than 90%.
4. radiotherapy dose measuring device according to claim 3, is characterized in that: described detector rotary apparatus (1) controls whole EMCCD detectors (2) and carries out 360 ° of rotations around a certain center.
5. a measuring method for radiotherapy dose measuring device described in any one of claim 1-4, is characterized in that comprising the following steps:
1) according to knub position and size, the distributing position of adjustment detector rotary apparatus position, EMCCD detector and wide-angle lens focal length size;
2) before radiation treatment, the measurement parameter according to device in therapeutic process is arranged, and utilizes wide-angle lens to obtain stray radiation background data and the ambient light background data of single angle;
3) in radiation therapy process, the even parameter of computer processing unit control EMCCD detector rotary apparatus rotates and fixed point remaining, space angle information when multi-channel data registration collection module receives simultaneously and integrates optical signal data and the EMCCD detector measurement of three EMCCD detectors, passes to computer processing unit;
4) optical signal data that each angle obtains is deducted stray radiation background data and ambient light background data respectively, obtain the Cherenkov light light intensity data of each angle;
5) utilize the Cherenkov light light intensity data of each angle and corresponding space angle information to carry out optical fault reconstruction, obtain the unit volume Cherenkov light light distribution N(x of tumor and peripheral region thereof, y, z);
6) based on the quantitative ratio relation between Cherenkov light light intensity and dosage deposition, according to unit volume Cherenkov light light distribution N(x, y, z) obtain Dose Distribution in Radiotherapy Treatment D(x, y, z).
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106772529A (en) * 2016-11-28 2017-05-31 北京格物时代科技发展有限公司 A kind of dose of radiation remains activity value monitoring method and system
CN109893778A (en) * 2019-03-15 2019-06-18 南京航空航天大学 A kind of particle radiation therapy beam method of real-time
CN110465002A (en) * 2019-07-09 2019-11-19 中国科学院西安光学精密机械研究所 Tumor radiotherapy real-time monitoring synchronous acquisition device and monitoring instrument based on CLI
CN111991710A (en) * 2020-08-24 2020-11-27 西安交通大学医学院第一附属医院 Radiotherapy position and dose real-time monitoring and positioning device and tumor radiotherapy system
CN114887237A (en) * 2022-04-15 2022-08-12 南京航空航天大学 Method and system for enhancing Cerenkov effect dose imaging effect
CN114984462A (en) * 2022-04-15 2022-09-02 南京航空航天大学 Cerenkov light dose monitoring method and device based on multi-channel imaging

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CN104755014A (en) * 2012-08-03 2015-07-01 光点医疗有限公司 Fibrescope for optical imaging of radiopharmaceuticals

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Publication number Priority date Publication date Assignee Title
US20030081303A1 (en) * 2001-09-12 2003-05-01 Micronic Laser Systems Ab Method and apparatus using an SLM
CN101262812A (en) * 2005-09-13 2008-09-10 皇家飞利浦电子股份有限公司 Optical tomography imaging device
CN104755014A (en) * 2012-08-03 2015-07-01 光点医疗有限公司 Fibrescope for optical imaging of radiopharmaceuticals

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106772529A (en) * 2016-11-28 2017-05-31 北京格物时代科技发展有限公司 A kind of dose of radiation remains activity value monitoring method and system
CN106772529B (en) * 2016-11-28 2019-03-29 北京格物时代科技发展有限公司 A kind of dose of radiation residual activity value monitoring method and system
CN109893778A (en) * 2019-03-15 2019-06-18 南京航空航天大学 A kind of particle radiation therapy beam method of real-time
CN109893778B (en) * 2019-03-15 2021-02-05 南京航空航天大学 Particle radiotherapy beam real-time monitoring method
CN110465002A (en) * 2019-07-09 2019-11-19 中国科学院西安光学精密机械研究所 Tumor radiotherapy real-time monitoring synchronous acquisition device and monitoring instrument based on CLI
CN111991710A (en) * 2020-08-24 2020-11-27 西安交通大学医学院第一附属医院 Radiotherapy position and dose real-time monitoring and positioning device and tumor radiotherapy system
CN114887237A (en) * 2022-04-15 2022-08-12 南京航空航天大学 Method and system for enhancing Cerenkov effect dose imaging effect
CN114984462A (en) * 2022-04-15 2022-09-02 南京航空航天大学 Cerenkov light dose monitoring method and device based on multi-channel imaging

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