CN114984152B - Traditional Chinese medicine composition for treating beef cattle transportation stress syndrome and application thereof - Google Patents

Traditional Chinese medicine composition for treating beef cattle transportation stress syndrome and application thereof Download PDF

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CN114984152B
CN114984152B CN202210805645.7A CN202210805645A CN114984152B CN 114984152 B CN114984152 B CN 114984152B CN 202210805645 A CN202210805645 A CN 202210805645A CN 114984152 B CN114984152 B CN 114984152B
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beef cattle
traditional chinese
chinese medicine
medicine composition
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CN114984152A (en
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史秋梅
高桂生
高光平
张志强
吴同垒
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Hubei Tianhe Beef Cattle Farming Ltd
Hebei Normal University of Science and Technology
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Hubei Tianhe Beef Cattle Farming Ltd
Hebei Normal University of Science and Technology
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Abstract

The invention discloses a traditional Chinese medicine composition for treating beef cattle transportation stress syndrome, and belongs to the technical field of medicines. The preparation method comprises the following raw materials: the Chinese herbal medicines comprise eight immortals grass, cudweed, cacumen biotae, lophatherum gracile, chinese knotweed, hawthorn, medicated leaven, mint and liquorice. The invention provides a novel traditional Chinese medicine composition for treating beef cattle transportation stress syndrome, which has a good treatment effect on sick cattle, remarkably improves the cure rate of the sick cattle and shortens the treatment time. The invention also provides a preparation method of the traditional Chinese medicine composition oral liquid and powder.

Description

Traditional Chinese medicine composition for treating beef cattle transportation stress syndrome and application thereof
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating beef cattle transportation stress syndrome and application thereof
Background
At present, four large beef belts exist in beef cattle raising industry in China, namely, a middle-source beef belt which is centered on Huaihai and yellow sea plains, and northeast, southwest and west beef belts which are composed of northeast three provinces and the eastern part of inner Mongolia, and the south is relatively lack of enough beef cattle resources, so that 'easily fattening', 'North-propagating-North-south-north beef south-south regulation' is a main mode of beef cattle production in China, and in the transportation process, the beef cattle can have multiple beef cattle transportation stress syndromes due to the influence of various stress sources, the morbidity is 60%, the mortality is 2-15%, and huge economic losses are brought to beef cattle farmers.
The beef cattle transportation stress syndrome is a syndrome of the beef cattle affected by various stressors in the transportation process, which leads to the reduction of organism immunity, infection of various pathogens and causes pathological reactions of respiratory tracts, digestive tracts and even whole bodies. Clinically beef cattle manifest as inappetence, fever, coughing, runny nose, dyspnea, diarrhea and even bloody stool. Pathogenic bacteria causing respiratory symptoms mainly include Pasteurella multocida, klebsiella, mannheimia, and Mycoplasma bovis, and pathogenic bacteria causing digestive tract symptoms mainly include Escherichia coli and Salmonella.
At present, antibiotics western medicines are mostly adopted as medicines for treating the beef cattle transportation stress syndrome, and have certain curative effects, but the western medicines have serious drug resistance and side effects, and the medicine residues can influence the food safety of meat, so that potential threat is brought to human health; the Chinese herbal medicine has the characteristics of nature, no toxic or side effect and no chemical drug residue, and at present, although the traditional Chinese medicine for preventing and treating the beef cattle transportation stress syndrome also exists, the practical curative effect is poor, the cure rate is low, the treatment course is long and the cost is high.
Therefore, the traditional Chinese medicine composition for treating the beef cattle transportation stress syndrome, which has good curative effect, high cure rate and short treatment course, and the application thereof are the problems to be solved by the technicians in the field.
Disclosure of Invention
Aiming at the problems, the invention provides a traditional Chinese medicine composition for treating beef cattle transportation stress syndrome and application thereof, and the traditional Chinese medicine composition has the advantages of good curative effect, high cure rate, short treatment course and the like in the aspect of treating beef cattle transportation stress by researching the components and the proportion of the traditional Chinese medicine composition.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating beef cattle transportation syndrome comprises the following components in parts by weight: 5-7 parts of hydrangea, 4-6 parts of cudweed, 2-4 parts of cacumen biotae, 2-4 parts of lophatherum gracile, 2-4 parts of herb of Chinese knotweed, 2-4 parts of hawthorn, 1-2 parts of medicated leaven, 1-2 parts of mint and 1-2 parts of liquorice.
Preferably, the traditional Chinese medicine composition for treating beef cattle transportation syndrome further comprises the following components in parts by weight: 5 parts of hydrangea, 4 parts of cudweed, 2 parts of cacumen biotae, 2 parts of lophatherum gracile, 2 parts of charcoal, 2 parts of hawthorn, 1 part of medicated leaven, 1 part of mint and 1 part of liquorice.
The efficacy of the eight immortals grass: the name of the cleaver is as follows. Bitter and pungent in flavor and slightly cold in nature. It enters the channels of the shaoyin and taiyin. Contains protopine, ha Erming alkali, crystal lanoside, chlorogenic acid, etc. Has inhibiting effect on Staphylococcus aureus, escherichia coli, and Bacillus He Liji. Has antibacterial, antiinflammatory, heat-clearing and detoxicating, blood circulation promoting, blood stasis dispelling, and water eliminating effects. Can be used for treating dysentery, carbuncle, toxic swelling, edema, common cold, and fever.
Efficacy of cudweed: aliases include mouse ear, herba phoropterygii, etc. Sweet in flavor and neutral in nature. It enters liver, heart and spleen meridians. Contains volatile oil, stigmasterol, potassium chloride, potassium nitrate, luteolin, and affine cuisine. Has inhibiting effect on Staphylococcus aureus and Bacillus dysenteriae Song. Has effects of regulating middle warmer, invigorating qi, relieving cough, and eliminating phlegm, and can be used for treating asthma and bronchitis.
Arborvitae She Gongxiao: aliases cypress, huang Xinbai, etc. Bitter and astringent taste, slightly cold nature, enter lung, liver and large intestine meridians. Contains volatile oil mainly comprising anisone, camphora, camphol acetate, terpene alcohol, hinokitiol, kaempferide, hinokitiol, wax, etc. Other flavonoid components such as bergamot essence, quercetin, myricetin, hinokitiol, etc.; the leaves also contain trace elements such as potassium, sodium, nitrogen, phosphorus, calcium, magnesium, manganese, zinc and the like. Has inhibiting effect on Staphylococcus aureus, cardiococcus, bacillus dysenteriae, typhoid bacillus, diphtheria bacillus, etc. Has effects of cooling blood, stopping bleeding, relieving cough and asthma. Can be used for treating hematemesis, epistaxis, bloody dysentery, rheumatalgia, bacillary dysentery, cough, etc.
Lophatherum gracile She Gongxiao: aliased bamboo leaves, crushed bone, bamboo leaf roll cores and the like. Sweet in flavor and cold in nature. It enters heart, lung, stomach and bladder meridians. The stems of Lophatherum gracile and She Fuhan triterpene compounds, aerial parts contain organic acids, saccharides, flavonoids and bioactive polysaccharides, and also contain microelements such as manganese, zinc, selenium, etc. Has inhibiting effect on Staphylococcus aureus and hemolytic streptococcus. Has obvious immunity enhancing effect and can improve the body resistance to adverse environment and diseases. Has effects of clearing heat and detoxicating, eliminating carbuncle and swelling pain, relieving fever and promoting urination. Can be used for treating chest heat, cough, qi upward, hematemesis, diabetes, phlegm, and dysphoria, palpitation, heat and spleen.
The efficacy of the charcoal master batch: aliases of Pimpinella, mars, marsdenia tenacissima, etc. Warm nature, slightly sour and slightly astringent. It enters heart and liver meridians. Contains carthamin yellow and carthamin, and is hydrolyzed with hydrochloric acid to obtain glucose and carthamin. And polyphenols such as chlorogenic acid, dynorphic acid, catechol, etc. The beverage also contains more than eighty volatile components, and has the determined structure of ethyl acetate, benzene, 1-pentene-3-alcohol and the like, and also contains rhamnose, arabinose, xylose, glucose, oleic acid, linoleic acid and the like. Has effects of clearing heat and detoxicating, promoting diuresis and removing food stagnation, cooling blood and relieving itching, improving eyesight and removing nebula. Can be used for treating dysentery, enteritis, dyspepsia, common cold, and pharyngolaryngitis.
The efficacy of the hawthorns: also called mountain fruit and mountain red. Sweet and sour in flavor and slightly warm in nature. Enters spleen, stomach and liver meridians. Contains vitamin C, a large amount of carotene, calcium, red pigment, crataegolic acid, pectin, lipolytic enzyme and various medicinal components. The burnt hawthorn and the fresh hawthorn have stronger inhibition effect on dysentery bacillus, and can obviously inhibit staphylococcus aureus, beta streptococcus, escherichia coli, bacillus proteus, bacillus anthracis, diphtheria bacillus, typhoid bacillus, pseudomonas aeruginosa and the like. Has effects of invigorating spleen, stimulating appetite, resolving food stagnation, promoting blood circulation, and eliminating phlegm, and can be used for treating chest distress, spleen fullness, blood stasis, dysentery, abdominal pain, etc.
Medicated leaven efficacy: the medicated leaven is a leaven agent prepared by adding flour or bran into the mixture of the polygonum hydropiper, the sweet wormwood, the almond paste, the red bean and the fresh fructus xanthil and fermenting. Sweet and pungent taste and warm nature, enter spleen and stomach meridians. The main components are saccharomycetes, amylase, volatile oil, fatty oil, vitamin B and the like. Has effects of invigorating spleen, stimulating appetite, resolving food stagnation, regulating qi-flowing, strengthening spleen and stomach, relieving exterior syndrome, dispelling cold, eliminating dampness, and eliminating phlegm. Can be used for treating dyspepsia, anorexia, abdominal distention, emesis, diarrhea, phlegm retention, cough, and limb edema.
Peppermint efficacy: aliases such as Su Bo, shu Bo He, yu Xiang and ren Dan Cao, etc., pungent and cool in nature. It enters lung and liver meridians. Contains volatile oil, wherein the main component of the oil is menthol, and then menthone, and further contains menthyl acetate, camphene, limonene, isomenthone, pinene menthenone, resin, a small amount of tannins and rosmarinic acid. In addition, leaves contain various free amino acids such as threonine, alanine, glutamic acid, asparagine, etc. Has effects of dispelling pathogenic wind heat, clearing heat from throat, promoting eruption, removing toxic substance, dispersing stagnated liver qi for relieving qi stagnation and relieving itching, and can be used for treating symptoms such as no sweat, hernia pain and scrofula.
Licorice efficacy: the Chinese medicinal herbs include Lao Guo, tian Cao, wu La Er Cao, tian Shen Zi, etc., are sweet in taste and neutral in nature, enter twelve meridians. Mainly contains glycyrrhizic acid, glycyrrhizin, 24-hydroxy glycyrrhetinic acid, licoflavone, glycyrrhizin, isoliquiritigenin, and Glycyrrhrizae radix polysaccharide. Glycyrrhizic acid is a natural antidote, and can be used for resisting aging, enhancing immunity, and maintaining water and salt metabolism balance. Has effects of invigorating spleen, replenishing qi, clearing heat, detoxicating, relieving spasm, relieving pain, and harmonizing various drugs. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, abdominal pain, and relieving drug toxicity and intensity.
The formula of the invention is as follows: the invention relates to a beef cattle transportation stress syndrome, which mainly causes the beef cattle to have symptoms of high fever, cough, running clear water nasal discharge, diarrhea and the like during or after transportation due to factors such as long-distance transportation, hunger thirst, crowding, mixed population, environmental mutation and the like; lophatherum gracile and Chinese knotweed herb can be used for treating vexation and palpitation caused by long-distance transportation, and can be used for removing heat and relieving spleen and treating enteritis and cold; hawthorn fruit and medicated leaven can strengthen stomach and promote digestion, and lower qi to regulate middle warmer; the mint has stronger permeation effect, can promote the medicine to be spread in intestinal tracts in an accelerating way, is uniformly distributed, permeates and absorbs to mucous membranes, strengthens the antibacterial and anti-inflammatory effects, and is favorable for fully exerting the curative effect of the medicine; the liquorice is sweet in taste and can tonify qi, harmonize the middle-jiao and spleen, and unblock twelve main and collateral channels to harmonize various medicines. The Chinese medicinal materials in the formula are combined, have the effects of clearing heat and detoxicating, resisting bacteria and diminishing inflammation, and improving the immunity and disease resistance of organisms, and are suitable for beef cattle transportation syndromes caused by various stresses.
The invention also provides application of the traditional Chinese medicine composition for treating the beef cattle transportation syndrome in preparation of a medicine for treating the beef cattle transportation stress syndrome.
Preferably, the medicament comprises the following dosage forms: oral liquid and powder.
Preferably, the oral liquid is prepared by the following method:
1) Pretreatment of raw materials: weighing the raw materials according to the proportion, crushing into coarse powder, and soaking for 1h;
2) Concentrating by decoction: taking the pretreated crude drugs in the step 1, adding water for first decoction, boiling water, decocting with slow fire for 30min, and filtering to obtain filtrate 1 and filter residue 1; adding water into the filter residue 1 for a second time, and decocting with slow fire for 20min to obtain filtrate 2 and filter residue 2; decocting the residue 2 with water for the third time, decocting with slow fire for 20min to obtain filtrate 3, mixing the three filtrates, concentrating, adding 0.05% sodium benzoate as antiseptic, and diluting with water to 1g per ml of crude drug to obtain the final product.
Preferably, in the preparation process of the oral liquid, the weight-volume ratio of the raw material medicine to water for the first time is 1:8; the weight-volume ratio of the filter residue 1 and water in the second decoction is 1:6; the weight-volume ratio of the filter residue 2 and water in the third decoction is 1:6.
Preferably, the powder is prepared by the following method: weighing the raw materials according to the proportion, pulverizing into coarse powder, and sieving with a 40-60 mesh sieve to obtain traditional Chinese medicine powder.
Compared with the prior art, the invention has the following beneficial effects: the invention provides a traditional Chinese medicine composition for treating beef cattle transportation syndrome, which is screened according to the ancient formula of traditional medicine and by combining modern epidemiology, etiology and immunology theory on the basis of a large number of practical applications, and is used for treating beef cattle transportation stress syndrome, and has the advantages of short treatment course, high cure rate, low cost, safety and no toxic or side effect.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
Weighing the following raw materials (decoction pieces) in parts by weight, 250g of hydrangea macrophylla, 200g of cudweed, 100g of cacumen biotae, 100g of lophatherum gracile, 100g of charcoal, 100g of hawthorn, 50g of medicated leaven, 50g of mint and 50g of liquorice; pulverizing the above raw materials into coarse powder respectively, and sieving with 40-60 mesh sieve; soaking in 8000mL water for 1h, decocting, boiling water, and decocting with slow fire for 30min; filtering to obtain filtrate 1 and residue 1, adding 6000mL of water into residue 1, decocting for 20min for the second time, and filtering to obtain filtrate 2 and residue 2; adding 6000mL of water into the filter residue 2, decocting for 20min, filtering to obtain filtrate 3, mixing the three filtrates, concentrating to 900mL, adding 0.05% sodium benzoate as antiseptic, adding water to 1000mL, stirring, filtering, packaging, and sterilizing to obtain the traditional Chinese medicine oral liquid for treating beef cattle transportation stress syndrome.
Example 2
Weighing the following raw materials (decoction pieces) in parts by weight, 240g of hydrangea macrophylla, 160g of cudweed, 120g of cacumen biotae, 120g of lophatherum gracile, 120g of charcoal, 120g of hawthorn, 40g of medicated leaven, 40g of mint and 40g of liquorice; pulverizing the above raw materials into coarse powder respectively, and sieving with 40-60 mesh sieve; soaking in 8000mL water for 1h, decocting, boiling water, and decocting with slow fire for 30min; filtering to obtain filtrate 1 and residue 1, adding 6000mL of water into residue 1, decocting for 20min for the second time, and filtering to obtain filtrate 2 and residue 2; adding 6000mL of water into the filter residue 2, decocting for 20min, filtering to obtain filtrate 3, mixing the three filtrates, concentrating to 900mL, adding 0.05% sodium benzoate as antiseptic, adding water to 1000mL, stirring, filtering, packaging, and sterilizing to obtain the traditional Chinese medicine oral liquid for treating beef cattle transportation stress syndrome.
1. The traditional Chinese medicine composition of the invention is used for drug sensitivity test of main pathogenic bacteria of beef cattle transportation stress syndrome
Preparation of pathogenic bacteria: selecting a beef cattle case with clinical transport stress syndrome, and separating and identifying 2 pathogenic bacteria with stronger pathogenicity: pasteurella multocida and E.coli. Inoculating clinically isolated Pasteurella multocida to cottonInoculating Escherichia coli into Maiconk agar medium, culturing at 37deg.C for 18 hr, selecting typical colony, inoculating into 5mL broth, culturing at 37deg.C for 18 hr, and diluting to 10 with 0.5 McUK standard turbidimetric tube 6 CFU/mL E.coli diluted to 10 5 CFU/mL was ready for use.
Drug sensitivity test: the drug sensitivity test was performed using the oral liquid of the Chinese medicinal composition prepared in example 1 of the present invention as a test group and penicillin, ampicillin, and ciprofloxacin as a control group. Inoculating Pasteurella multocida to sheep fresh blood agar medium, inoculating Escherichia coli to Maiconkai agar medium, punching the culture medium by plate punching method, and adding 1g/mL of the Chinese herbal medicine oral liquid of the invention into the holes respectively, preferably to fill up but not overflow the holes. Paper sheets of three antibiotics of 10 IU/tablet of penicillin, 10 mug/mL of ampicillin and 5 mug/mL of ciprofloxacin are taken as drug sensitivity test control, and are placed in a constant temperature incubator at 37 ℃ for culturing for 24 hours, the diameter of a bacteriostasis circle is measured, the drug sensitivity test of each drug is repeated three times, and the drug sensitivity test results are shown in table 1:
TABLE 1 results of drug sensitivity test of different drugs against two bacteria
Determination criteria: according to the standards of traditional Chinese medicine pharmacology and drug sensitivity test standardization related to 2005 edition of American clinical laboratory standardization institute, namely, the antibacterial diameter is more than or equal to 20mm and is extremely sensitive, and the antibacterial diameter is more than or equal to 15mm and is highly sensitive; 15mm antibacterial diameter is equal to or larger than 10mm, and is middle sensitization, and lower sensitization below 10 mm.
Table 1 shows that the oral liquid of example 1 is extremely sensitive to Pasteurella multocida and Escherichia coli, and has antibacterial diameters of 23mm and 24mm, respectively, and the ciprofloxacin, ampicillin and penicillin are inferior to the invention. The Chinese herbal medicine oral liquid has better inhibition effect on two pathogenic bacteria of the beef cattle transportation stress syndrome than three antibiotics of penicillin, ampicillin and ciprofloxacin, and is the first choice in the practice of preventing and treating the beef cattle transportation stress syndrome.
2. Example 1 test of the therapeutic Effect of oral liquid on beef cattle Transit stress syndrome
The transport stress syndrome naturally occurs in beef cattle, which are respectively provided by farmers in Changli county, 28390 can county and Letin county in Hebei province, and is confirmed to be the transport stress syndrome according to clinical symptoms and laboratory examination results. The Chinese medicinal composition of the invention is used as a test group, ciprofloxacin is used as a control group, the sick cattle are treated, the cure rate is counted, and the treatment results are shown in tables 2 and 3.
Standard of medication: the Chinese herbal medicine oral liquid is mixed into water according to the dosage of 50 ml/head for the sick cattle, and the administration is carried out for 5-7 days for a treatment course, wherein the administration is carried out 1 time a day. Ciprofloxacin administration standard: orally taking 2.5-5 mg/kg body weight.
Cure rate criterion: after the medicine is used, the patient is continuously observed for 3 to 5 days, the patient is judged to be cured by the disappearance of clinical symptoms, the drinking water, the ingestion and the recovery of mental state, and then the prevention and treatment effect is determined by combining the pathological section detection sampling detection result, so that the cure rate is counted.
Table 2: example 1 Effect of oral liquid on treating naturally occurring beef cattle transportation stress syndrome
Table 3: effect of ciprofloxacin control group on treating naturally-occurring beef cattle transportation stress syndrome
The oral liquid of the embodiment 1 has obvious treatment effect on the transport stress syndrome of the beef cattle by treating 157 naturally-occurring transport stress syndromes of the beef cattle, the average cure rate is 99 percent, and the symptoms generally disappear through 6 to 7 days, so that normal feeding is recovered; and the ciprofloxacin control group treats 152 beef cattle transportation stress syndromes with natural morbidity, the average cure rate is 96.71%, and the 7d symptoms disappear, so that normal feeding is recovered. The traditional Chinese medicine composition has better treatment effect on the beef cattle transportation stress syndrome than that of a ciprofloxacin control group.
3. Detection of hematological index before and after administration of drug for treating beef cattle transportation stress syndrome
And selecting 20 beef cattle (10 beef cattle in a traditional Chinese medicine treatment group and a ciprofloxacin group) with clinically confirmed diagnosis of the beef cattle transportation stress syndrome in a certain cattle farm of Changli, 8 beef cattle in a synchronous healthy control group (healthy control group), and 10 beef cattle in a diseased control group (diseased group, which is not treated by medication). The traditional Chinese medicine composition treatment group and ciprofloxacin beef cattle are respectively treated by the oral liquid of the example 1 and ciprofloxacin (oral liquid of 2.5-5 mg/kg body weight) after the patients are diagnosed, the dosage is 50mL each, 1 time a day, and 6d is 1 course of treatment. Example 1 oral liquid and ciprofloxacin-treated beef cattle were collected once for each jugular vein before and after administration of the confirmed diagnosis, and red blood cell count, hemoglobin content, and the like were performed. The healthy beef cattle control group and the diseased beef cattle control group are subjected to synchronous blood sampling, and erythrocyte counting and hemoglobin content measurement are also carried out. The measurement results of the number of erythrocytes, the amount of hemoglobin and the hematocrit in blood are shown in Table 4.
Table 4: measurement of the number of red blood cells, the amount of hemoglobin and the hematocrit in blood
As can be seen from table 2, the number of red blood cells, the content of hemoglobin and the hematocrit of healthy beef cattle are maintained at the normal level basically, and the number of red blood cells, the content of hemoglobin and the hematocrit of injured beef cattle are small, and the number of red blood cells, the content of hemoglobin and the hematocrit of beef cattle in the treatment group of example 1 are maintained at the normal level after the beef cattle are cured by the drug, which indicates that both the oral liquid of example 1 and the ciprofloxacin can increase the number of red blood cells, the content of hemoglobin and the hematocrit of beef cattle, but the effect of the oral liquid of example 1 is better than that of the treatment group of ciprofloxacin. Erythrocytes and hemoglobin play an important role in hematopoiesis and oxygen transport in the body, are important for animal survival, growth and production, and have a partial immune function. After the oral liquid of the embodiment 1 treats the beef cattle transportation stress syndrome, the three indexes are obviously increased to reach normal values, which shows that the Chinese herbal medicine oral liquid of the invention has the function of increasing the number of red blood cells and the content of hemoglobin in blood.
The experimental result shows that the Chinese herbal medicine oral liquid for treating the beef cattle transportation stress syndrome has the effects of clearing heat and detoxicating, resisting bacteria and diminishing inflammation, and improving the immunity and disease resistance of organisms.
In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (7)

1. The traditional Chinese medicine composition for treating beef cattle transportation syndrome is characterized by comprising the following raw material medicines in parts by weight: 5-7 parts of hydrangea, 4-6 parts of cudweed, 2-4 parts of cacumen biotae, 2-4 parts of lophatherum gracile, 2-4 parts of herb of Chinese knotweed, 2-4 parts of hawthorn, 1-2 parts of medicated leaven, 1-2 parts of mint and 1-2 parts of liquorice.
2. The traditional Chinese medicine composition for treating beef cattle transportation syndrome according to claim 1, wherein the raw material medicines comprise the following components in parts by weight: 5 parts of hydrangea, 4 parts of cudweed, 2 parts of cacumen biotae, 2 parts of lophatherum gracile, 2 parts of charcoal, 2 parts of hawthorn, 1 part of medicated leaven, 1 part of mint and 1 part of liquorice.
3. Use of a traditional Chinese medicine composition according to any one of claims 1-2 for the preparation of a medicament for the treatment of beef cattle transportation stress syndrome.
4. Use of a traditional Chinese medicine composition according to claim 3 for preparing a medicament for treating beef cattle transportation stress syndrome, wherein the dosage form of the medicament comprises: oral liquid and powder.
5. The application of the traditional Chinese medicine composition in preparing a medicine for treating beef cattle transportation stress syndrome according to claim 4, wherein the oral liquid is prepared by the following method:
1) Pretreatment of raw materials: weighing the raw materials according to the proportion, crushing into coarse powder, and soaking for 1h;
2) Concentrating by decoction: taking the pretreated crude drugs in the step 1, adding water for first decoction, boiling water, decocting with slow fire for 30min, and filtering to obtain filtrate 1 and filter residue 1; adding water into the filter residue 1 for a second time, and decocting with slow fire for 20min to obtain filtrate 2 and filter residue 2; decocting the residue 2 with water for the third time, decocting with slow fire for 20min to obtain filtrate 3, mixing the three filtrates, concentrating, adding 0.05% sodium benzoate as antiseptic, and diluting with water to 1g per ml of crude drug to obtain the final product.
6. The use of the Chinese medicinal composition according to claim 5 in preparing a medicament for treating beef cattle transportation stress syndrome, wherein in the preparation process of the oral liquid, the weight-volume ratio of the first decoction raw material medicament to water is 1:8; the weight-volume ratio of the filter residue 1 and water in the second decoction is 1:6; the weight-volume ratio of the filter residue 2 and water in the third decoction is 1:6.
7. The use of the traditional Chinese medicine composition according to claim 4 for preparing a medicament for treating beef cattle transportation stress syndrome, wherein the powder is prepared by the following method: weighing the raw materials according to the proportion, pulverizing into coarse powder, and sieving with a 40-60 mesh sieve to obtain traditional Chinese medicine powder.
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CN102511687A (en) * 2011-12-26 2012-06-27 河南中医学院 Chinese herbal composite feed additive used for transportation stress recovery of beef cattle
CN104222523A (en) * 2014-09-26 2014-12-24 中国农业科学院北京畜牧兽医研究所 Anti-stress feed additive and preparation method thereof
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