CN114982972B - Method for preparing qi-yin-deficiency health care capsule food by extracting high-quality protein from blood meat animals and Chinese herbal medicines - Google Patents
Method for preparing qi-yin-deficiency health care capsule food by extracting high-quality protein from blood meat animals and Chinese herbal medicines Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing qi-yin deficiency health care capsule food by selecting and extracting high-quality protein from blood meat animals and Chinese herbal medicines. The method comprises the following steps: (1) Sequentially adding the blood meat fragments and water into an extraction container, heating and extracting, opening a condensing valve when the temperature of the extracting solution reaches 105 ℃, filtering and taking filtrate for standby until the surface liquid is distilled; (2) Adding auxiliary materials into the filtrate, and uniformly stirring to obtain high-quality protein nutrient solution extracted from the blood meat animals; (3) Adding Chinese herbal medicine composite functional powder into the nutrient solution obtained in the step (2), uniformly stirring, collecting after spray drying, filling and packaging by capsules to obtain the qi-yin deficiency health care capsule food. The capsule food produced by the preparation method provided by the invention not only can better extract and retain nutritional ingredients, but also has the health care effects of tonifying qi and nourishing yin, nourishing liver and kidney, promoting blood circulation and soothing the nerves aiming at sub-health of qi-yin deficiency and crowd physique requiring health care.
Description
Technical Field
The invention belongs to the technical field of functional foods, and particularly relates to a method for preparing qi-yin deficiency health care capsule food by selecting and using high-quality protein extracted from blood meat animals and Chinese herbal medicines.
Background
According to the medical prediction report of health in 2020 issued by Defei, the global population is rapidly moving to the aging stage, and the population of China also enters the serious aging stage, so that the population of the elderly people over 60 years old in China reach over 2 hundred million in the present stage according to incomplete statistics. With the continuous progress of aging of the population, a series of social problems are generated. Especially for the elderly, the physiological functions gradually decline, the immune functions are reduced, and the risk of illness is increased. From the aspects of disease treatment and health care, prevention is greater than treatment, and improvement of the immune function of the aged is one of the main directions for preventing the occurrence of chronic diseases of the aged.
According to the related researches, the old people with more than 60 people mostly have the constitution of qi-yin deficiency, and the long-term qi-yin deficiency can lead to the human immunity reduction, especially the old people, and the prevalence rate of the old people with more than 60 years is up to 56 percent in recent years. Aiming at the current situation of qi-yin deficiency, the development of healthy and healthy food with dietary therapy effect can meet the urgent demands of the middle-aged and elderly consumer groups with qi-yin deficiency physique.
Disclosure of Invention
The invention aims at sub-health of qi-yin deficiency and physique of people needing to be nourished, and provides a method for preparing qi-yin deficiency health care capsule food by extracting high-quality protein from blood meat animals and Chinese herbal medicines. The capsule food produced by the preparation method provided by the invention not only can better extract and retain nutritional ingredients, but also has the health care effects of tonifying qi and nourishing yin, nourishing liver and kidney, promoting blood circulation and soothing the nerves aiming at sub-health of qi-yin deficiency and crowd physique requiring health care.
In order to achieve the above purpose, the invention adopts the following technical scheme: a method for preparing qi-yin deficiency health care capsule food by extracting high-quality protein from blood meat animals and Chinese herbal medicines comprises the following steps:
(1) Sequentially adding the blood meat poultry fragments and water into an extraction container, heating and extracting, opening a condensation valve when the temperature of the extracting solution reaches 105 ℃, filtering and taking filtrate for standby until the surface liquid is distilled;
(2) Adding auxiliary materials into the filtrate, and uniformly stirring to obtain high-quality protein nutrient solution extracted from blood meat poultry animals;
(3) Adding Chinese herbal medicine composite functional powder into the nutrient solution obtained in the step (2), uniformly stirring, collecting after spray drying, filling and packaging by capsules to obtain the qi-yin deficiency health care capsule food.
According to the application study of traditional Chinese medicine theory and modern medicine to the biotechnology field, the invention proves that the combination of high-quality animal protein with a certain content and natural edible plant medicine in diet can obviously enhance the immunity of human body. The poultry provided by the invention is selected from the poultry which is qualified in quarantine and meets the requirements of food safety standards in a biological laboratory or a special production operation place.
Preferably, the blood meat poultry crumb in step (1) is obtained by the steps of: after the poultry is slaughtered, dehaired, eviscerated, blood meat poultry is obtained, and the blood meat poultry is cleaned and minced to obtain blood meat poultry fragments.
Preferably, the poultry in step (1) include black-bone chickens, rabbits, tortoises, crocodiles, and pigeons.
In the invention, black-bone chicken: enter the liver and kidney meridians. Sweet in nature and flat in taste. Liver and kidney tonifying, qi and blood invigorating, and deficiency heat clearing away. Rabbits: entering liver; the large intestine channel. Sweet in taste; cold property; strengthening spleen and tonifying middle-jiao; cool blood and detoxify. Tortoise: enter liver, lung and spleen; wen Weigan acid; dehumidify arthralgia, tonify yin deficiency, nourish kidney water, stop bleeding and detoxify. Crocodile can tonify qi and blood, nourish heart and lung, strengthen tendons and bones, and expel damp evils. Pigeon: entering the lung; liver; kidney meridian. Salty taste; the sex is flat. Nourishing kidney and tonifying qi, dispelling wind and detoxicating, regulating menstruation and relieving pain.
Further preferably, the blood meat poultry fragments in the step (1) comprise, by mass, 11.56-11.67 parts of black-bone chickens, 4.38-4.76 parts of rabbits, 3.40-3.89 parts of tortoises, 2.72-3.40 parts of crocodiles and 2.03-2.92 parts of pigeons.
Further preferably, the mass ratio of the blood meat poultry fragments to the water in the step (1) is 24.09:75.91-26.64:73.36. Still further preferably, the mass ratio of blood meat poultry crumb to water is 24.98:75.02.
preferably, the Chinese herbal medicine composite functional powder in the step (3) comprises the following components in parts by weight: 33.26-33.31 parts of hyacinth bean powder, 23.57-26.65 parts of Chinese yam powder, 18.86-20.79 parts of horseshoe powder, 6.66-7.07 parts of mulberry powder, 6.66-7.07 parts of medlar powder, 2.00-2.38 parts of American ginseng powder, 2.00-4.16 parts of shizandra berry powder, 0.50-0.94 parts of lucid ganoderma powder and 0.05-0.21 part of saffron powder. Further preferably, the Chinese herbal medicine composite functional powder in the step (3) comprises the following components in parts by weight: 33.26 parts of hyacinth bean powder, 26.65 parts of Chinese yam powder, 20.79 parts of horseshoe powder, 6.66 parts of mulberry powder, 6.66 parts of medlar powder, 2.00 parts of American ginseng powder, 2.00 parts of shizandra berry powder, 0.50 part of lucid ganoderma powder and 0.05 part of saffron powder.
In the invention, hyacinth beans: enters the spleen and stomach meridians. Sweet and flat. Strengthening spleen, regulating middle warmer, relieving summer heat and eliminating dampness; chinese yam: spleen, lung and kidney meridians; sweet and flat. Spleen and stomach tonifying, body fluid generating, lung benefiting, kidney tonifying and seminal emission astringing; water chestnut: enter the lung and stomach meridians. Sweet and cold. Clearing heat, resolving phlegm and removing food retention; mulberry: feeding into the heart; liver and kidney meridians. Sweet, sour and cold. Replenishing blood, nourishing yin, promoting fluid production and moistening dryness; medlar: enter liver and kidney meridians; sweet and flat. Nourishing liver and kidney, replenishing vital essence and improving eyesight; american ginseng: enters heart, lung and kidney meridians. Sweet, slightly bitter and cool. Tonifying qi, nourishing yin, clearing heat and promoting fluid production; chinese magnoliavine fruit: enter the lung, heart and kidney meridians; taste acid; warm nature. Astringing, inducing astringency, invigorating qi, promoting salivation, calming heart, and tranquilizing mind; ganoderma lucidum: it enters heart, lung, liver and kidney meridians. Sweet and flat. Tonifying qi, soothing the nerves, relieving cough and asthma; saffron crocus: feeding into the heart; the liver meridian. Sweet; flat. Promoting blood circulation, removing blood stasis, resolving stagnation, cooling blood and removing toxic substance.
Preferably, the mass ratio of the nutrient solution to the Chinese herbal medicine composite functional powder is 73.55-84.99: 15.01 to 26.45. Further preferably, the mass ratio of the nutrient solution to the Chinese herbal medicine composite functional powder is 78.79:21.21.
Preferably, the particle size of each component in the Chinese herbal medicine composite functional powder is 60 meshes.
Preferably, the auxiliary material in the step (2) is potassium sorbate. The addition amount of the potassium sorbate is 0.75-0.78% of the mass of the nutrient solution.
The invention also protects the health care capsule food for treating the deficiency of qi and yin, which is prepared by the method.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention does not use chemical preparation in the preparation process, thereby ensuring that the nutrition components of the raw materials can be fully reserved. The formula components are mainly prepared by compounding high-quality protein nutrient solution extracted from various blood-meat poultry animals and medicinal and edible Chinese herbal medicines, the formula is prepared from cool American ginseng, mulberry, water chestnut powder, and Chinese wolfberry and lucid ganoderma which are flat in nature, so that qi and yin are benefited, tranquillization and dryness moistening are realized, the sour Chinese magnoliavine fruit is astringed and astringed, the flat beans and Chinese yam are used for invigorating spleen and qi, and the saffron with little adjuvant can promote blood circulation and dispel depression. Meanwhile, the rabbit meat, the crocodile meat, the pigeon meat and the black chicken meat which are slightly cold are selected as main materials, and the turtle meat which is slightly warm is added, so that the effects of tonifying qi and blood, nourishing liver and kidney and strengthening bones and muscles can be achieved together.
2. The invention can cause symptoms of hypodynamia, less Qi and no speaking, weak body, dryness, soreness of waist and knees, dysphoria with feverish sensation in chest and abdomen, dizziness and tinnitus, dry mouth and tongue and the like of people with qi-yin deficiency constitution, such as people who stay up at night frequently and eat food easy to get up with age, frequent sexual life times, chronic consumption diseases and the like. All have obvious improving effect, and can be used as a health-care functional food for people with yin deficiency constitution.
3. The capsule food produced by the preparation method provided by the invention not only can better extract and retain nutritional ingredients, but also has the health care effects of tonifying qi and nourishing yin, nourishing liver and kidney, promoting blood circulation and soothing the nerves aiming at sub-health of qi-yin deficiency and crowd physique requiring health care.
Drawings
Fig. 1 shows changes in organs of mice in each treatment group in experimental example 1, wherein the yin deficiency capsule group refers to a high dose group of yin deficiency capsules.
Detailed Description
The following examples are further illustrative of the invention and are not intended to be limiting thereof. The experimental methods without specific conditions noted in the examples below are generally in accordance with conventional conditions in the art or in accordance with manufacturer's recommendations; the raw materials, reagents and the like used, unless otherwise specified, are considered to be commercially available through conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art in light of the above teachings are intended to be within the scope of the invention as claimed.
Example 1:
a method for preparing qi-yin deficiency health care capsule food by adopting blood meat poultry animals to extract high-quality protein and Chinese herbal medicines comprises the following steps:
(1) Selecting qualified black-bone chicken, rabbit, tortoise, crocodile and pigeon which are subjected to slaughter dehairing, head removing and viscera removing through a biological laboratory or a special production and operation place meeting the food safety standard requirements, cleaning and cutting up;
(2) Adding 11.56% of black-bone chickens, 4.38% of rabbits, 3.40% of tortoises, 2.72% of crocodiles and 2.92% of pigeons into a multifunctional extraction tank according to the total mass fraction of the blood-bone poultry and clear water of 100%, and heating and extracting under the pressure of 0.1 Mpa;
(3) When the temperature of the extracting solution reaches 105 ℃, opening a condensing valve until the surface liquid is distilled, filtering the residual materials of the extracting tank, and taking filtrate;
(4) Slowly adding potassium sorbate with the mass of 0.76% of the filtrate into the filtrate obtained in the step (3), and uniformly stirring to obtain high-quality protein nutrient solution extracted from blood meat poultry animals;
(5) The nutrient solution obtained in the step (4) is added with Chinese herbal medicine composite functional powder which is prepared from 33.26 parts of hyacinth bean powder, 26.65 parts of Chinese yam powder, 20.79 parts of horseshoe powder, 6.66 parts of mulberry powder, 6.66 parts of medlar powder, 2.00 parts of American ginseng powder, 2.00 parts of schisandra chinensis powder, 0.50 part of lucid ganoderma powder and 0.05 part of saffron powder according to the mass ratio of 78.79:21.21, the two are uniformly stirred, and the mixture is subjected to capsule filling and filling according to 0.5 g/capsule after spray drying, so that the qi-yin-deficiency healthy capsule food is obtained.
Comparative example 1
The preparation method of the capsule food 1 comprises the following steps:
(1) Selecting qualified black-bone chicken, rabbit, tortoise, crocodile and pigeon which are subjected to slaughter dehairing, head removing and viscera removing through a biological laboratory or a special production and operation place meeting the food safety standard requirements, cleaning and cutting up;
(2) Adding 11.56% of black-bone chickens, 4.38% of rabbits, 3.40% of tortoises, 2.72% of crocodiles and 2.92% of pigeons into a multifunctional extraction tank according to the total mass fraction of the blood-bone poultry and clear water of 100%, and heating and extracting under the pressure of 0.1 Mpa;
(3) When the temperature of the extracting solution reaches 105 ℃, a condensing valve is opened until the surface liquid is distilled, the residual materials of the extracting tank are filtered, and the filtrate is taken to obtain the high-quality protein nutrient solution extracted from the blood meat poultry animals;
(4) And (3) spray-drying the nutrient solution obtained in the step (3), and filling capsules according to 0.5 g per granule, and filling to obtain the capsule food 1.
1. The capsule food 1 obtained in comparative example 1 was tested, and the content of effective nutritional ingredients is shown in table 1:
2. as a food, 100 volunteers with yin deficiency were taken 12 g a day (three meals a day, 8 grains each after half an hour of a meal) without the assistance of other drugs, 1% of the volunteers had a relief of yin deficiency symptoms after 7 days of consumption, 8% of the volunteers had a relief of yin deficiency symptoms after 10 days of consumption, 15% of the volunteers had a relief of yin deficiency symptoms after 15 days of consumption, and 38% of the volunteers had a relief of yin deficiency symptoms after 25 days of consumption.
Comparative example 2
The preparation method of the capsule food 2 comprises the following steps: 33.26 parts of 60-mesh hyacinth bean powder, 26.65 parts of Chinese yam powder, 20.79 parts of horseshoe powder, 6.66 parts of mulberry powder, 6.66 parts of medlar powder, 2.00 parts of American ginseng powder, 2.00 parts of shizandra berry powder, 0.50 part of lucid ganoderma powder and 0.05 part of saffron powder are uniformly mixed and stirred, and then capsule filling and filling are carried out according to 0.5 g per capsule, thus obtaining the capsule food 2.
1. The capsule food 2 obtained in comparative example 2 was tested, and the content of effective nutritional ingredients is shown in table 2:
3. as a food, 100 volunteers with yin deficiency were taken 12 g a day (three meals a day, 8 grains each after half an hour of a meal) without the assistance of other drugs, with 10% of the volunteers having a relief in yin deficiency symptoms after 7 days of consumption, 28% of the volunteers having a relief in yin deficiency symptoms after 10 days of consumption, 48% of the volunteers having a relief in yin deficiency symptoms after 15 days of consumption, and 63% of the volunteers having a relief in yin deficiency symptoms after 25 days of consumption.
Example 2
A method for preparing qi-yin deficiency health care capsule food by adopting blood meat poultry animals to extract high-quality protein and Chinese herbal medicines comprises the following steps:
(1) Selecting qualified black-bone chicken, rabbit, tortoise, crocodile and pigeon which are subjected to slaughter dehairing, head removing and viscera removing through a biological laboratory or a special production and operation place meeting the food safety standard requirements, cleaning and cutting up;
(2) Adding 11.67% of black-bone chickens, 4.76% of rabbits, 3.89% of tortoises, 3.40% of crocodiles and 2.03% of pigeons into a multifunctional extraction tank according to the total mass fraction of the blood-bone poultry and clear water of 100%, and heating and extracting under the pressure of 0.1 Mpa;
(3) When the temperature of the extracting solution reaches 105 ℃, opening a condensing valve until the surface liquid is distilled, filtering the residual materials of the extracting tank, and taking filtrate;
(4) Slowly adding potassium sorbate with the mass of 0.78% of the filtrate into the filtrate obtained in the step (3), and uniformly stirring to obtain high-quality protein nutrient solution extracted from blood meat poultry animals;
(5) The nutrient solution obtained in the step (4) is added with Chinese herbal medicine composite functional powder which is composed of 33.31 parts of hyacinth bean powder, 23.57 parts of Chinese yam powder, 18.86 parts of horseshoe powder, 7.07 parts of mulberry powder, 7.07 parts of medlar powder, 2.38 parts of American ginseng powder, 4.16 parts of schisandra chinensis powder, 0.94 part of lucid ganoderma powder and 0.21 part of saffron powder according to the mass ratio of 73.55:26.45, the two are uniformly stirred, and the mixture is subjected to capsule filling and filling according to 0.5 g/granule after spray drying, so that the qi-yin-deficiency healthy and nourishing capsule food is obtained.
Experimental example 1
1. The capsule for healthy and nourishing with deficiency of qi and yin obtained in example 1 was tested, and the content of effective nutritional ingredients is shown in table 3:
2. as a food, 100 volunteers with yin deficiency were taken 12 g a day (three meals a day, 8 grains each after half an hour of a meal) without the assistance of other drugs, 35% of the volunteers had a relief of yin deficiency symptoms after 7 days of consumption, 52% of the volunteers had a relief of yin deficiency symptoms after 10 days of consumption, 83% of the volunteers had a relief of yin deficiency symptoms after 15 days of consumption, and 96% of the volunteers had a relief of yin deficiency symptoms after 25 days of consumption.
3. Acute toxicity study of Qi Yin deficiency rehabilitation Capsule (Yin deficiency Capsule)
1. Experimental grouping
The test sample is administered multiple times a day by maximum dose method. 40 ICR mice were divided into different dosing groups and one control group of 10 animals each. The control group was given the same volume of distilled water as the administration group. The specific experimental animal grouping and lavage volume conditions are shown in table 4. The yin deficiency capsule obtained in example 1 was dissolved in water to form a solution with a mass concentration of 0.3 g/mL.
2. Experimental observation and analysis
After the yin-deficiency capsule was dissolved in water (0.3 g/mL), administration was completed according to the amount of gastric lavage of table 4, followed by continuous observation for 14 days, and the reaction of animals within 48 hours after administration was closely observed. According to the requirements of relevant content of traditional Chinese medicine and natural medicine acute toxicity research technical guidelines, the condition of toxic reaction of animals, the occurrence time, duration, recovery time and shortest death time, longest death time, average death time and number of dead animals of the animals are recorded in detail, the dead animals are subjected to autopsy in time, abnormal animals are observed by naked eyes for pathological histology examination, and the records are but not limited to the following:
(1) animal appearance: whether the skin color is changed, whether the skin has red swelling, spots, luster of hair, etc
(2) The nervous system: behavior and response, abnormal movement, response to stimulus, neural reflex, twitch, and muscular tension.
(3) Respiratory function: depth and frequency of breathing, nasal secretions, wheezing, and whether shortness of breath and pauses occur.
(4) Motion function: the gait, increase or decrease of movement, abnormal movement, prone position, tremor, fasciculi and the like of the mice are observed.
(5) Reflection function: the cornea eyelid is examined for closure, righting reflex, stretch reflex, light reflex.
(6) Eye indications: such as herniation, ptosis, conjunctival turbidity, iritis, conjunctivitis.
(7) Cardiovascular indications: the blood vessel expands.
(8) Gastrointestinal indications: fecal character, abdominal morphology, and the like.
(9) Urogenital indications: external genitalia condition.
At the end of the observation period, the surviving animals are sacrificed after weighing and are subjected to anatomical examination, the changes of organs such as heart, liver, kidney, spleen, lung, stomach and intestine are observed, if obvious changes exist, pathological examination is further performed, the weights of the organs are counted, and the organ coefficients are recorded.
3. Experimental results
After the mice are subjected to gastric lavage treatment for 14 days by using yin-deficiency capsules with different dosages, compared with a control group, the appearance of the mice is normal, no death phenomenon occurs, the appearance, the action and the posture of the mice are not obviously abnormal, which indicates that the LD50 of the yin-deficiency capsules is larger than the maximum tolerance dosage of the mice, and no obvious acute toxicity exists.
The maximum dose of the mice was converted to 1.5 g/kg body weight, which is about 87.5 times the normal dose (1.2 g/70 kg) for adults, showing good safety.
Because the test sample has no obvious toxicity, in order to make the experimental result simple and visual, only the normal control group and the yin deficiency capsule high-dose experimental group are analyzed later.
(1) Appearance observation of experimental animal
The animals have no obvious abnormality in diet and activity before and after administration, and the excreta has normal appearance. No animal death was observed throughout the experiment. Through continuous observation, the mice before and after administration have no obvious abnormality in appearance, clear mind, steady action gait, fresh hair color and no salivation and nasal discharge (tables 5 and 6).
(2) Recording of changes in body weight of mice before and after administration
Mice were weighed at different time points and found to have a weight change substantially consistent with the trend of the control group after receiving the intragastric administration treatment, and the weight of the yin-deficiency capsule-administered mice was significantly higher than that of the control group on days 11 and 14 of administration (table 7).
(3) Visceral change record of experimental animal after gastric lavage treatment
After the end of the experiment, animals of the administration group and the control group were roughly dissected, and no obvious abnormal changes were observed in organs such as heart, lung, liver, spleen, kidney and stomach of each group of mice (see tables 8 and 9). And weighing partial organs such as liver, spleen, lung, kidney and reproductive organs, calculating related organ coefficients (organ weight/weight), wherein compared with a control group, the yin deficiency capsule administration treatment group (yin deficiency capsule high dose group) has no obvious difference in indexes of main organs such as heart, lung, liver and kidney, and is interesting that the indexes of spleen and thymus of a mice in the yin deficiency capsule group are obviously increased, so that the yin deficiency capsule can promote the growth of immune organs of the mice and improve the immunity of the mice.
(4) Pathological examination of partial organs of mice
And (3) respectively taking partial viscera of each group of mice, performing histopathological examination by tissue section, wherein the viscera of each treatment group of mice are not found to have obvious abnormal lesions, as shown in figure 1, the viscera are uniform in texture, clear in nuclear mass edge, regular in shape, free of tissue necrosis phenomenon, complete in liver and spleen tissue morphology, and free of obvious abnormal in structure.
5. Conclusion(s)
After the mice are infused with different doses of yin-deficiency capsules within one day, continuous observation is carried out for 14 days, no abnormal reaction is seen in the animals during the whole observation period, and no death condition of the animals is seen. The weight measurement results show that the weight of the mice is significantly higher than that of the control group after one week of gastric lavage of the yin deficiency capsule. Through tissue observation and histopathological examination, the yin deficiency capsules are not found to have obvious adverse effects on main organs of mice, but the increase of spleen and thymus quality is obviously promoted.
The results show that the yin deficiency capsule has no obvious acute toxicity to experimental mice, and has obvious growth promoting effect on main immune organs of the mice.
Experimental example 2 therapeutic Effect of yin deficiency Capsule on mice with kidney yin deficiency
Taking 20 ICR mice of 6-7 weeks old, dividing into control group and yin deficiency capsule administration group, dissolving yin deficiency capsule in water, administering to mice via stomach infusion, taking blood 50 μl from orbital venous plexus of mice 1 min and 5 min after injection, and dissolving in 0.1% Na of 3 mL once daily for 21 consecutive days, 1 hr after each administration, and intravenous injection of 25% Indian ink 20 mL/kg at tail of mice 2 CO 3 Shaking the solution, standing for 30 min, and exposing to ultravioletOD was measured at 680 and nm on a spectrophotometer at 0.1% Na 2 CO 3 The solution is a blank control; taking liver and spleen of a mouse after cervical vertebra removal and sacrifice, sucking blood by filter paper, weighing, and calculating clearance index and phagocytosis index in unit time according to the following calculation formula
Clearance index= (lgOD 1-lgOD 5)/(t 5-t 1);
phagocytic index (α) =k×body weight/(liver weight+spleen weight);
the K and alpha values of the drug group and the control group are counted, and t value test is carried out. The test data were analyzed using SPSS software and the results are shown in table 10.
From the above results, the medicinal liquid of the embodiment 1 of the invention is infused with 0.2. 0.2 mL/10g of body weight per day, and after 21 days, the clearance index and the phagocytic index of the mice are obviously improved relative to the control group, the difference is obvious (P < 0.01), namely the yin deficiency capsule can obviously improve the phagocytic capacity of mononuclear-macrophages, and the yin deficiency capsule is prompted to obviously improve the immunity of organisms.
Experimental example 3 Effect of yin deficiency Capsule on mice with kidney yin deficiency
The main research content is as follows
Healthy Kunming mice were 30, 5-6 weeks old, and after one week of adaptive rearing, the mice were randomly divided into 3 groups of 10. The specific grouping is as follows:
control group i.e. intraperitoneal injection
Physiological saline 0.3 mL/1 times/day for 7 consecutive days.
Kidney yin deficiency group: hydrocortisone 50 mg/(kg body weight. Day) was injected intraperitoneally for 7 consecutive days;
treatment group with kidney yin deficiency: the dosage of the oral capsule solution for curing the deficiency of stomach-yin is 10 mL/kg body weight, and the oral capsule solution is continuously 7 days.
During the experiment, the mice drink water freely, the appearance form and the activity state of the mice are observed every day, relevant records are made, and after the 7-day experiment treatment period is ended, the blood of the mice is collected for relevant biochemical and biological index detection.
Experimental results:
(1) Morphological appearance observation
Normal mice have normal appearance and behavior, are bright in hair color, active in action, normal in diet and wet in feces in granular form. Mice with deficiency of kidney-yin have fluffy hair, inactive behaviors, dysphoria, irritability, biting, poor mental state, sparse stool and frequent extrados. After the yin-deficiency capsule is used for stomach irrigation, the hair color of the mice becomes bright, the activity of the mice is increased, and the feces are granular.
(2) Biochemical detection
By detecting the levels of FSH, testosterone and estrogen E2 in the serum of each group of mice, the levels of FSH and testosterone in the serum of the mice with kidney-yin deficiency are obviously lower than those of a normal control group (P < 0.05), but the change of the estrogen level is not obvious. After treatment with yin deficiency capsules, testosterone levels were significantly increased, the values were not significantly different from those of the normal group, FSH levels were also significantly increased, but there was still a large difference compared with the normal group; the yin deficiency capsule also reduces the estrogen level in the serum of mice with kidney yin deficiency to a certain extent, but the difference is not obvious, and the specific experimental results are shown in table 11.
Experimental example 4 Effect of yin deficiency Capsule on people with deficiency of Qi and Yin
With reference to the "clinical study guidelines for New Chinese medicine" (trial run), 60 candidates were selected in combination with the dialectical criteria of Chinese medicine, including compliance with the dialectical criteria of Chinese medicine with deficiency of qi and yin, age 40-78 years, informed consent of group personnel, etc. The individuals after the group were subjected to the differentiation of symptoms in the traditional Chinese medicine by a single blind method, and the individuals were classified into 6 grades according to the severity of symptoms according to asymptomatic symptoms (0 score), mild symptoms (1 score), lighter symptoms (2 score), moderate symptoms (3 score), heavier symptoms (4 score) and severe symptoms (5 score) and scored and counted.
The group-entering personnel take blood with a hollow stomach again, obtain a serum sample, detect relevant biochemical indexes of TNF alpha, IL-1, IFN gamma and other cytokines, and then carry out the detection and record relevant data after the group-entering personnel take the capsules with yin deficiency for two weeks.
Experimental results:
based on the inclusion criteria, there were finally 46 persons included in the study cohort, wherein 21 serum samples were obtained for the relevant biochemical factor detection, and the specific results are shown in Table 12.
As can be seen from the table 12, after the yin-deficiency capsule is taken, the symptoms of people with deficiency of qi and yin are obviously relieved, and the symptoms of palpitation and shortness of breath are mainly relieved, the phenomena of spontaneous perspiration and night sweat and dry mouth are obviously improved, the complexion, the lip color and the tongue characterization are obviously improved, and the pulse condition is stable. The level of each inflammatory factor is obviously reduced.
The results show that the yin deficiency capsules have remarkable improving effect on the symptoms of people with qi and yin deficiency.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that the above-mentioned preferred embodiment should not be construed as limiting the invention, and the scope of the invention should be defined by the appended claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (6)
1. A method for preparing a qi-yin-deficiency health care capsule food by extracting high-quality protein from blood meat animals and Chinese herbal medicines is characterized by comprising the following steps:
(1) Sequentially adding blood meat fragments and water into an extraction container for heating and extracting, and when the temperature of an extracting solution reaches 105 ℃, opening a condensing valve until surface liquid is distilled, filtering and taking filtrate for later use, wherein the blood meat fragments comprise, by mass, 11.56-11.67 parts of black-bone chickens, 4.38-4.76 parts of rabbits, 3.40-3.89 parts of tortoises, 2.72-3.40 parts of crocodiles and 2.03-2.92 parts of pigeons;
(2) Adding auxiliary materials into the filtrate, and uniformly stirring to obtain high-quality protein nutrient solution extracted from the blood meat animals;
(3) Adding Chinese herbal medicine composite functional powder into the nutrient solution obtained in the step (2), uniformly stirring, and collecting after spray drying to obtain the qi-yin deficiency health care capsule food, wherein the mass ratio of the nutrient solution to the Chinese herbal medicine composite functional powder is 73.55-84.99: 15.01-26.45 parts of Chinese herbal medicine composite functional powder, which comprises the following components in parts by mass: 33.26-33.31 parts of hyacinth bean powder, 23.57-26.65 parts of Chinese yam powder, 18.86-20.79 parts of horseshoe powder, 6.66-7.07 parts of mulberry powder, 6.66-7.07 parts of medlar powder, 2.00-2.38 parts of American ginseng powder, 2.00-4.16 parts of shizandra berry powder, 0.50-0.94 parts of lucid ganoderma powder and 0.05-0.21 part of saffron powder.
2. The method of claim 1, wherein the blood meat pieces of step (1) are obtained by: the animal is slaughtered, dehaired, and eviscerated, and then cleaned and chopped to obtain blood and meat fragments.
3. The method of claim 1, wherein the mass ratio of blood meat pieces to water in step (1) is 24.09:75.91-26.64:73.36.
4. The method according to claim 1, wherein the particle size of each component in the herbal composite functional powder is 60 mesh.
5. The method of claim 1, wherein the auxiliary material in the step (2) is potassium sorbate, and the addition amount of the potassium sorbate is 0.75-0.78% of the mass of the filtrate.
6. The health care capsule food for treating deficiency of qi and yin, which is prepared by the method of claim 1.
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| CN108403931A (en) * | 2018-05-15 | 2018-08-17 | 江西益佰年药业股份有限公司 | A kind of black chicken oral liquid and preparation method thereof |
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| CN108403931A (en) * | 2018-05-15 | 2018-08-17 | 江西益佰年药业股份有限公司 | A kind of black chicken oral liquid and preparation method thereof |
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