CN114981307A - 抗btla抗体药物组合物及其用途 - Google Patents

抗btla抗体药物组合物及其用途 Download PDF

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Publication number
CN114981307A
CN114981307A CN202180009885.XA CN202180009885A CN114981307A CN 114981307 A CN114981307 A CN 114981307A CN 202180009885 A CN202180009885 A CN 202180009885A CN 114981307 A CN114981307 A CN 114981307A
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China
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cancer
buffer
sodium chloride
antibody
histidine
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CN202180009885.XA
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Inventor
刘洪川
刘沛想
张静
周岳华
刘辉
陈雪茹
王静
冯辉
姚盛
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Shanghai Junshi Biosciences Co Ltd
Suzhou Junmeng Biosciences Co Ltd
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Shanghai Junshi Biosciences Co Ltd
Suzhou Junmeng Biosciences Co Ltd
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Publication of CN114981307A publication Critical patent/CN114981307A/zh
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract

提供一种稳定的抗BTLA(B和T淋巴细胞弱化子)抗体的药物组合物及其在医药上的应用。该药物组合物含有抗BTLA抗体、缓冲液，还可以含有至少一种稳定剂，任选的还可以含有表面活性剂。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202180009885.XA 2020-01-20 2021-01-19 抗btla抗体药物组合物及其用途 Pending CN114981307A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010066932.1A CN113134081A (zh) 2020-01-20 2020-01-20 抗btla抗体药物组合物及其用途
CN2020100669321 2020-01-20
PCT/CN2021/072660 WO2021147846A1 (zh) 2020-01-20 2021-01-19 抗btla抗体药物组合物及其用途

Publications (1)

Publication Number Publication Date
CN114981307A true CN114981307A (zh) 2022-08-30

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CN202010066932.1A Pending CN113134081A (zh) 2020-01-20 2020-01-20 抗btla抗体药物组合物及其用途
CN202180009885.XA Pending CN114981307A (zh) 2020-01-20 2021-01-19 抗btla抗体药物组合物及其用途

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US (1) US20230192854A1 (zh)
EP (1) EP4095158A4 (zh)
JP (1) JP2023510928A (zh)
KR (1) KR20220129564A (zh)
CN (2) CN113134081A (zh)
AU (1) AU2021211795A1 (zh)
BR (1) BR112022013292A2 (zh)
CA (1) CA3165369A1 (zh)
WO (1) WO2021147846A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117693362A (zh) * 2021-08-02 2024-03-12 甘李药业股份有限公司 含有抗il-4r抗体的稳定制剂
WO2023125483A1 (zh) * 2021-12-28 2023-07-06 山东先声生物制药有限公司 一种抗tnfr2抗体药物组合物
US20230322929A1 (en) 2022-04-12 2023-10-12 Shanghai Junshi Biosciences Co., Ltd. Compositions and Methods for Treating Solid Tumors with Anti-BTLA as Mono or Combination Therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102762593A (zh) * 2009-07-31 2012-10-31 米德列斯公司 抗btla的完全人抗体
CN110790837A (zh) * 2018-08-02 2020-02-14 上海君实生物医药科技股份有限公司 抗btla抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546541B2 (en) * 2002-06-20 2013-10-01 Washington University Compositions and methods for modulating lymphocyte activity
CA3013333A1 (en) * 2016-02-26 2017-08-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antibodies having specificity for btla and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102762593A (zh) * 2009-07-31 2012-10-31 米德列斯公司 抗btla的完全人抗体
CN110790837A (zh) * 2018-08-02 2020-02-14 上海君实生物医药科技股份有限公司 抗btla抗体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRYSTAL M. PAULOS等: "Putting the brakes on BTLA in T cell-mediated cancer immunotherapy", 《THE JOURNAL OF CLINICAL INVESTIGATION》, vol. 120, no. 1, 31 January 2010 (2010-01-31), pages 76 - 80, XP055143199, DOI: 10.1172/JCI41811 *
王月颖等: "BTLA在T细胞上的表达和功能", 《细胞与分子免疫学杂志》, no. 03, 18 March 2009 (2009-03-18), pages 83 - 85 *

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AU2021211795A1 (en) 2022-09-15
US20230192854A1 (en) 2023-06-22
CN113134081A (zh) 2021-07-20
EP4095158A4 (en) 2024-03-20
CA3165369A1 (en) 2021-07-29
JP2023510928A (ja) 2023-03-15
EP4095158A1 (en) 2022-11-30
WO2021147846A1 (zh) 2021-07-29
BR112022013292A2 (pt) 2022-09-06
KR20220129564A (ko) 2022-09-23

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