CN114981288A - 一种抗体结合的特征性表位及其应用 - Google Patents
一种抗体结合的特征性表位及其应用 Download PDFInfo
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- CN114981288A CN114981288A CN202080094292.3A CN202080094292A CN114981288A CN 114981288 A CN114981288 A CN 114981288A CN 202080094292 A CN202080094292 A CN 202080094292A CN 114981288 A CN114981288 A CN 114981288A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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Abstract
提供一种多肽片段及其制备方法，所述多肽片段包含从N端至C端如X1X 2X 3X 4X 5GX 6所示的氨基酸序列，其中，X1为S、T、E、Y或F；X2为T、N、G、S或D；X3为H、E、Y、T、K、R或A；X4为G、Y、H、R或M；X5为A、F、Q、H、I或V；X6为W或F。还公开了编码该多肽的分离的核酸分子，并利用该多肽来制作针对PCSK9的多肽疫苗。该多肽片段可与抗PCSK9抗体结合，可检测、筛选或辅助筛选新的抗PCSK9抗体，从而缓解患者对原抗体出现免疫原性强等不良反应的问题。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/104876 WO2022021000A1 (zh) | 2020-07-27 | 2020-07-27 | 一种抗体结合的特征性表位及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114981288A true CN114981288A (zh) | 2022-08-30 |
| CN114981288B CN114981288B (zh) | 2024-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080094292.3A Active CN114981288B (zh) | 2020-07-27 | 2020-07-27 | 一种抗体结合的特征性表位及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114981288B (zh) |
| WO (1) | WO2022021000A1 (zh) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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