CN114929733A - 调节性t细胞表面抗原的表位和与其特异性结合的抗体 - Google Patents
调节性t细胞表面抗原的表位和与其特异性结合的抗体 Download PDFInfo
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- CN114929733A CN114929733A CN202080077856.2A CN202080077856A CN114929733A CN 114929733 A CN114929733 A CN 114929733A CN 202080077856 A CN202080077856 A CN 202080077856A CN 114929733 A CN114929733 A CN 114929733A
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2019-0142251 | 2019-11-08 | ||
| KR20190142251 | 2019-11-08 | ||
| PCT/KR2020/015656 WO2021091359A1 (ko) | 2019-11-08 | 2020-11-09 | 조절 t 세포 표면 항원의 에피토프 및 이에 특이적으로 결합하는 항체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114929733A true CN114929733A (zh) | 2022-08-19 |
Family
ID=75848106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080077856.2A Pending CN114929733A (zh) | 2019-11-08 | 2020-11-09 | 调节性t细胞表面抗原的表位和与其特异性结合的抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250243272A1 (https=) |
| EP (1) | EP4056586A4 (https=) |
| JP (1) | JP2023500248A (https=) |
| KR (1) | KR102488967B1 (https=) |
| CN (1) | CN114929733A (https=) |
| AU (1) | AU2020380072B2 (https=) |
| BR (1) | BR112022008730A2 (https=) |
| CA (1) | CA3156600A1 (https=) |
| WO (1) | WO2021091359A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112912402A (zh) * | 2018-10-17 | 2021-06-04 | 古德T细胞有限公司 | Lrig-1蛋白的特异性结合分子及其用途 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117716238A (zh) * | 2021-07-16 | 2024-03-15 | 古德T细胞有限公司 | 调节性t细胞表面抗原的表位及其特异性结合的抗体 |
| US20250018033A1 (en) * | 2021-11-24 | 2025-01-16 | Regcell Co., Ltd. | Human inducibility controllable t-cell and method for preparing same |
| KR20240115192A (ko) * | 2023-01-17 | 2024-07-25 | 주식회사 굳티셀 | 조절 t 세포 표면 항원 및 이에 특이적으로 결합하는 항체 |
| CN120882739A (zh) * | 2023-03-10 | 2025-10-31 | 古德T细胞有限公司 | 调节性t细胞表面抗原的表位,以及特异性结合该表位的抗体 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120251509A1 (en) * | 2009-10-22 | 2012-10-04 | Waldman Scott A | Cell-based anti-cancer compositions and methods of making and using the same |
| US20150239964A1 (en) * | 2011-01-24 | 2015-08-27 | Sang-Kyou Lee | Novel Use of Regulatory T Cell-Specific Surface Protein LRIG-1 |
| KR20180022761A (ko) * | 2018-02-26 | 2018-03-06 | 연세대학교 산학협력단 | 조절자 T 세포에 특이적으로 존재하는 새로운 표면단백질 Lrig-1의 용도 |
| WO2018194381A1 (ko) * | 2017-04-18 | 2018-10-25 | 주식회사 굳티셀 | Lrig-1 단백질에 특이적인 결합 분자 및 이의 용도 |
| KR20180116925A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 암 또는 면역 질환의 예방 또는 치료용 약학 조성물 |
| KR20180116924A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 면역 세포 표면 단백질의 항원 결정기인 폴리펩티드 |
| CN110036027A (zh) * | 2016-12-08 | 2019-07-19 | 伊玛提克斯生物技术有限公司 | 新型t细胞受体及其免疫治疗应用 |
| KR20190124665A (ko) * | 2018-04-26 | 2019-11-05 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3755350A4 (en) * | 2018-02-23 | 2021-11-03 | TrueBinding, Inc. | TREATING CANCER BY BLOCKING THE INTERACTION OF VISTA AND HIS ASSOCIATION PARTNER |
-
2020
- 2020-11-09 US US17/758,550 patent/US20250243272A1/en not_active Abandoned
- 2020-11-09 WO PCT/KR2020/015656 patent/WO2021091359A1/ko not_active Ceased
- 2020-11-09 CA CA3156600A patent/CA3156600A1/en active Pending
- 2020-11-09 AU AU2020380072A patent/AU2020380072B2/en active Active
- 2020-11-09 KR KR1020200148886A patent/KR102488967B1/ko active Active
- 2020-11-09 EP EP20885858.9A patent/EP4056586A4/en active Pending
- 2020-11-09 CN CN202080077856.2A patent/CN114929733A/zh active Pending
- 2020-11-09 JP JP2022525129A patent/JP2023500248A/ja active Pending
- 2020-11-09 BR BR112022008730A patent/BR112022008730A2/pt unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120251509A1 (en) * | 2009-10-22 | 2012-10-04 | Waldman Scott A | Cell-based anti-cancer compositions and methods of making and using the same |
| US20150239964A1 (en) * | 2011-01-24 | 2015-08-27 | Sang-Kyou Lee | Novel Use of Regulatory T Cell-Specific Surface Protein LRIG-1 |
| CN110036027A (zh) * | 2016-12-08 | 2019-07-19 | 伊玛提克斯生物技术有限公司 | 新型t细胞受体及其免疫治疗应用 |
| WO2018194381A1 (ko) * | 2017-04-18 | 2018-10-25 | 주식회사 굳티셀 | Lrig-1 단백질에 특이적인 결합 분자 및 이의 용도 |
| KR20180116925A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 암 또는 면역 질환의 예방 또는 치료용 약학 조성물 |
| KR20180116924A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 면역 세포 표면 단백질의 항원 결정기인 폴리펩티드 |
| KR20180022761A (ko) * | 2018-02-26 | 2018-03-06 | 연세대학교 산학협력단 | 조절자 T 세포에 특이적으로 존재하는 새로운 표면단백질 Lrig-1의 용도 |
| KR20190124665A (ko) * | 2018-04-26 | 2019-11-05 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Non-Patent Citations (2)
| Title |
|---|
| "leucine-rich repeats and immunoglobulin-like domains protein 1 precursor", 《BCBI》, 13 August 2019 (2019-08-13), pages 1 - 6 * |
| YIBIN XU ET AL: "LRIG1 extracellular domain: structure and function analysis", 《J MOL BIOL》, vol. 427, 22 May 2015 (2015-05-22), pages 1934 - 1948, XP055678885, DOI: 10.1016/j.jmb.2015.03.001 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112912402A (zh) * | 2018-10-17 | 2021-06-04 | 古德T细胞有限公司 | Lrig-1蛋白的特异性结合分子及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4056586A1 (en) | 2022-09-14 |
| CA3156600A1 (en) | 2021-05-14 |
| KR102488967B1 (ko) | 2023-01-16 |
| KR20210056280A (ko) | 2021-05-18 |
| WO2021091359A1 (ko) | 2021-05-14 |
| AU2020380072A1 (en) | 2022-05-19 |
| BR112022008730A2 (pt) | 2022-07-19 |
| EP4056586A4 (en) | 2024-04-10 |
| JP2023500248A (ja) | 2023-01-05 |
| US20250243272A1 (en) | 2025-07-31 |
| AU2020380072B2 (en) | 2025-11-27 |
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