CN114929028A - 包含胶原蛋白的膳食补充剂组合物 - Google Patents

包含胶原蛋白的膳食补充剂组合物 Download PDF

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CN114929028A
CN114929028A CN202180008381.6A CN202180008381A CN114929028A CN 114929028 A CN114929028 A CN 114929028A CN 202180008381 A CN202180008381 A CN 202180008381A CN 114929028 A CN114929028 A CN 114929028A
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K·赛登施蒂克
C·弗里泽
K·科特
C·卡特里
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Societe des Produits Nestle SA
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Abstract

本发明涉及通过改善身体表现和运动表现的胶原蛋白肽和膳食成分来改善身体表现和运动表现，并支持关节、韧带和肌腱的恢复。本发明的膳食补充剂组合物包含胶原蛋白(优选地呈水解的胶原蛋白肽的形式)与支链氨基酸(BCAA)、硝酸肌酸、硝酸精氨酸、N‑乙酰‑L‑肉碱、L‑瓜氨酸、无水甜菜碱、α‑甘油磷酰胆碱、含苹果果实提取物的古泥炭提取物和咖啡因的组合。身体表现和运动表现以及锻炼后的恢复能力通过使用该组分的组合得到改善。

Description

包含胶原蛋白的膳食补充剂组合物
技术领域
本发明涉及通过改善身体表现和运动表现的胶原蛋白肽和膳食成分来改善身体表现和运动表现，并支持关节、韧带和肌腱的恢复。本发明的膳食补充剂组合物包含胶原蛋白(优选地呈水解的胶原蛋白肽的形式)与支链氨基酸(BCAA)、硝酸肌酸、硝酸精氨酸、N-乙酰-L-肉碱、L-瓜氨酸、无水甜菜碱、α-甘油磷酰胆碱、含苹果果实提取物的古泥炭提取物和咖啡因的组合。身体表现和运动表现以及锻炼后的恢复能力通过使用该组分的组合得到改善。
背景技术
现代运动员，甚至是普通的健身爱好者，总是在健身房或球场上寻找优势，无论是在一英里跑中减少几秒钟的时间，还是在健身房进行额外的训练。在即将进行体力活动之前摄入营养饮料或饮料粉末混合物已成为一种优选方法，这有助于增强表现并使身体处于最佳状态。
除了对优化表现的需求之外，将胶原蛋白肽作为膳食补充剂服用与增强锻炼后的恢复能力相关，并提供氨基酸来支持肌肉、关节、韧带和肌腱，这些肌肉、关节、韧带和肌腱在锻炼或体力活动期间可能会受到应力或破坏(Chang等人，2014年，Clifford等人2019年)。
虽然充足的营养、睡眠和健康的生活方式是优化表现的核心，但某些可摄入的膳食补充剂和成分有可能最大限度地提高功率输出并增加能量、耐力和专注力。这些理想的参数可以通过改善循环、增加ATP能量、维持细胞水合作用和提供改善认知功能的营养物质来增强。研究表明，几种膳食补充剂成分具有促进这些增强表现的功能的固有特性，诸如硝酸肌酸、硝酸精氨酸、L-瓜氨酸、无水甜菜碱、α-甘油磷酰胆碱、含苹果果实提取物的古泥炭提取物和咖啡因。
然而，仍然需要改善表现并增加胶原蛋白的摄取。本发明解决了该缺陷并且基于组合物的组分增强了胶原蛋白肽的摄取并改善了运动表现。
发明内容
本发明涉及一种膳食补充剂组合物，其包含胶原蛋白肽、支链氨基酸(BCAA)、硝酸肌酸、硝酸精氨酸、N-乙酰-L-肉碱、L-瓜氨酸、无水甜菜碱、α-甘油磷酰胆碱、含苹果果实提取物的古泥炭提取物和咖啡因。组合物还可包含维生素，包括维生素C、烟酸、维生素B6或泛酸。
在一个实施方案中，胶原蛋白以组合物的约15重量％至约22重量％的量作为胶原蛋白肽的形式存在，包括亮氨酸、异亮氨酸、缬氨酸的支链氨基酸(BCAA)以组合物的约15重量％至约22重量％的量存在，L-瓜氨酸以组合物的约9重量％至约13重量％的量存在，无水甜菜碱以组合物的约7重量％至约11重量％的量存在，硝酸肌酸以组合物的约4.6重量％至约6.5重量％的量存在，硝酸精氨酸以组合物的约4.6重量％至约6.5重量％的量存在，N-乙酰肉碱以组合物的约1.5重量％至约2.2重量％的量存在，古泥炭提取物和苹果果实提取物的共混物以组合物的0.45重量％至约0.65重量％的量存在，并且咖啡因以组合物的约0.45重量％至约0.65重量％的量存在。
本发明的组合物可为粉末或液体的形式。
本发明的组合物旨在用于替代在体力活动期间分解的胶原蛋白，并改善身体表现和运动表现。
具体实施方式
本发明涉及一种膳食补充剂组合物，其可以作为补充剂服用以维持体内的胶原蛋白水平，这有助于支持肌肉、关节、肌腱和韧带，并且支持健康睡眠并改善身体表现和运动表现。
本发明的组合物包含胶原蛋白(优选地呈水解的胶原蛋白肽的形式)与支链氨基酸(BCAA)、硝酸肌酸、硝酸精氨酸、N-乙酰-L-肉碱、L-瓜氨酸、无水甜菜碱、α-甘油磷酰胆碱、含苹果果实提取物的古泥炭提取物和咖啡因的组合。该组合物可以液体、溶液、悬浮液、粉末或凝胶的形式使用。如果为粉末形式，则粉末如所指导的那样在施用之前在可溶性液体中混合。
胶原蛋白以组合物的约7重量％至30重量％、组合物的约11重量％至26重量％、或组合物的约15重量％至22重量％的量存在于组合物中。另选地，胶原蛋白可以以约2克/份至8克/份、约3克/份至7克/份或约5克/份的量存在于组合物中。在一个优选的实施方案中，胶原蛋白可以约5克/份的量存在于组合物中。胶原蛋白是蛋白质并且可以任何可用的形式存在于组合物中。然而，本发明优选地使用胶原蛋白肽。胶原蛋白肽可源自任何已知的来源，包括但不限于牛肉、鸡肉、鱼肉、蛋壳膜和鸡蛋白。在一个优选的实施方案中，胶原蛋白肽呈海洋胶原蛋白的形式，优选地来自白鱼。
必需的氨基酸是人类无法自己合成的氨基酸。这些氨基酸是苯丙氨酸、缬氨酸、苏氨酸、色氨酸、甲硫氨酸、亮氨酸、异亮氨酸、赖氨酸和组氨酸。这些氨基酸可以以约7重量％至30重量％、约11重量％至26重量％、或约15重量％至22重量％的量存在于组合物中。
作为亮氨酸、异亮氨酸和缬氨酸的支链氨基酸(BCAA)以约2g/份至8g/份、约3g/份至7g/份、约4g/份至6g/份或约5g/份的量存在于组合物中。另选地，支链氨基酸(BCAA)可以以约7重量％至30重量％、约11重量％至26重量％、或约15重量％至22重量％的量存在于组合物中。
L-瓜氨酸也以约1g/份至5g/份、约2g/份至4g/份、约2.5g/份至3.5g/份或约3g/份的量存在于组合物中。另选地，L-瓜氨酸可以以约3.7重量％至19重量％、约7重量％至15重量％、或约9重量％至13重量％的量存在于组合物中。
无水甜菜碱也以约1g/份至5g/份、约2g/份至4g/份、约2.5g/份至3.5g/份或约3克/份的量存在于组合物中。另选地，无水甜菜碱可以以约3.7重量％至19重量％、约7重量％至15重量％、或约9重量％至13重量％的量存在于组合物中。
硝酸肌酸也以约0.5g/份至3g/份、约1g/份至2g/份、约1.25g/份至1.75g/份或约1.5g/份的量存在于组合物中。另选地，硝酸肌酸可以以约1.8重量％至11.1重量％、约3.7重量％至7.4重量％、或约4.6重量％至6.5重量％的量存在于组合物中。
硝酸精氨酸也以约0.5g/份至3g/份、约1g/份至2g/份、约1.25g/份至1.75g/份或约1.5g/份的量存在于组合物中。另选地，硝酸精氨酸可以以约1.8重量％至11.1重量％、约3.7重量％至7.4重量％、或约4.6重量％至6.5重量％的量存在于组合物中。
N-乙酰-L-肉碱也以约0.1g/份至1.5g/份、约0.25g/份至0.75g/份、约0.4g/份至0.6g/份或约0.5g/份的量存在于组合物中。另选地，N-乙酰-L-肉碱可以以约0.35重量％至5.6重量％、约0.9重量％至2.8重量％、或约1.45重量％至2.25重量％的量存在于组合物中。
古泥炭提取物和苹果果实提取物的共混物也以约0.05g/份至0.3g/份、约0.1g/份至0.2g/份、约0.125g/份至0.175g/份或约0.15克/份的量存在于组合物中。另选地，古泥炭提取物和苹果果实提取物的共混物可以以约0.19重量％至1.11重量％、约0.37重量％至0.74重量％、或约0.46重量％至0.65重量％的量存在于组合物中。
咖啡因也以约0.05g/份至0.3g/份、约0.1g/份至0.2g/份、约0.125g/份至0.175g/份或约0.14g/份的量存在于组合物中。另选地，咖啡因可以以约0.19重量％至1.11重量％、约0.37重量％至0.74重量％、或约0.46重量％至0.65重量％的量存在于组合物中。
还可向组合物中添加维生素。适于以膳食补充剂摄取的任何维生素均是适用的。合适的维生素包括但不限于维生素B，包括维生素B1(例如，作为氯化硫胺素)、维生素B2(例如，作为核黄素)、维生素B3(例如，烟酰胺)、维生素B6(例如，作为盐酸吡哆醇)、维生素B5(例如，作为泛酸或D-泛酸钙)、维生素B12(氰钴胺)、叶酸盐(例如，作为叶酸)、维生素C(例如，作为抗坏血酸钠)、维生素D、维生素E等。在本发明的上下文中，所述维生素中的每一种维生素可以以约0克/份至0.2克/份、约0克/份至1克/份、约0.2克/份至0.8克/份、0.4克/份至0.6克/份、或总组合物的约0重量％至0.25重量％、约0重量％至0.2重量％、约0.001重量％至0.2重量％、约0.002重量％至0.175重量％的量独立地存在于组合物中。
此外，可使用任何已知的天然风味剂对组合物进行调味，以增强组合物的风味。另外，适用于膳食补充剂的其它添加剂，包括但不限于僧侣果提取物、喜马拉雅粉红海盐、果蔬汁粉、柠檬酸和苹果酸。
根据本发明，合适的组合物包括但不限于表1中所述的那些。
表1
Figure BDA0003732372360000041
Figure BDA0003732372360000051
**日常值未建立
在本发明的一个实施方案中，补充剂的热量摄取为每份小于约100卡路里、小于约75卡路里、或约40卡路里。另外，组合物中碳水化合物和总糖的量有利地较低。例如，碳水化合物可以以小于10克/份、小于7克/份、小于5克/份、约4克/份或约2克/份的量存在。类似地，总糖有利地保持较少，例如小于6克/份、小于5克/份、或约0克/份。如上所述，呈胶原蛋白或胶原蛋白肽的形式的蛋白质的含量较高，优选地高于2克/份，高于4克/份，或约5克/份。
实施例1
制备表1中描绘的配方的组合物。
参考文献
Chang等人,(2014)胶原蛋白分子的分子生物力学，今日材料，第17卷，第2期，2014年3月(Molecular biomechanics of collagen molecules,Materials Today,Volume 17,Number 2,March 2014)。
Clifford等人,(2019)胶原蛋白肽对锻炼后肌肉损伤、炎症和骨转换的影响：一项随机对照试验，氨基酸(2019)51:691–704(The effects of collagen peptides onmuscle damage,inflammation and bone turnover following exercise:a randomized,controlled trial,Amino Acids(2019)51:691–704)。

Claims (17)

1.膳食补充剂组合物，所述膳食补充剂组合物包含量为所述组合物的约30重量％至60重量％的胶原蛋白肽，量为所述组合物的约2重量％至约3.5重量％的谷氨酰胺，以及量为所述组合物的约0.2重量％至约0.5重量％的牛磺酸。
2.根据权利要求1所述的膳食补充剂组合物，其中所述组合物还包含至少一种选自以下的营养必需氨基酸：亮氨酸、异亮氨酸、缬氨酸、赖氨酸、苯丙氨酸、苏氨酸、色氨酸、组氨酸和甲硫氨酸，其量为所述组合物的约15重量％至22重量％或量为约8克/份。
3.根据权利要求2所述的膳食补充剂，其中所述组合物包含至少一种选自以下的支链氨基酸(BCCA)：亮氨酸、异亮氨酸和缬氨酸，其量为所述组合物的约15重量％至22重量％或量为约8克/份。
4.根据权利要求2或3所述的膳食补充剂，其中所存在的必需氨基酸的总量为约7重量％至30重量％、约11重量％至26重量％或约15重量％至22重量％的量。
5.根据权利要求2所述的膳食补充剂组合物，其中所述组合物为粉末。
6.根据权利要求2所述的膳食补充剂组合物，其中所述组合物为液体。
7.根据权利要求2所述的膳食补充剂组合物，其中胶原蛋白以所述组合物的约40重量％至55重量％的量存在，谷氨酰胺以所述组合物的2.75重量％至约3.0重量％的量存在，并且牛磺酸以所述组合物的约0.3重量％至0.45重量％的量存在。
8.根据权利要求2所述的膳食补充剂组合物，其中胶原蛋白以所述组合物的50重量％至55重量％的量存在，谷氨酰胺以所述组合物的约2.75重量％至3.0重量％的量存在，并且牛磺酸以所述组合物的约0.4重量％至0.42重量％的量存在。
9.根据权利要求2所述的膳食补充剂组合物，其中所述组合物还包含量为所述组合物的约10重量％至20重量％的椰子水。
10.根据权利要求2所述的膳食补充剂组合物，其中所述组合物还包含量为所述组合物的约12重量％至16重量％的椰子水。
11.根据权利要求2所述的膳食补充剂组合物，其中所述组合物还包含选自钠、钾、镁和锌的电解质。
12.根据权利要求2所述的膳食补充剂组合物，所述膳食补充剂组合物还包含选自以下的电解质：钠、钾、镁、钙、碳酸氢盐、氯化物和磷酸盐。
13.根据权利要求2所述的膳食补充剂组合物，所述膳食补充剂组合物还包含硒。
14.根据权利要求2所述的膳食补充剂组合物，所述膳食补充剂组合物还包含以下维生素中的一种或多种：维生素B1、维生素B2、维生素B3、维生素B6、维生素B5、叶酸、维生素C、维生素D和维生素E。
15.根据权利要求14所述的膳食补充剂组合物，其中所述组合物包含以下维生素中的每一种：维生素B1、维生素B2、维生素B3、维生素B6、维生素B5、叶酸、维生素C和维生素D。
16.膳食补充剂组合物，所述膳食补充剂组合物包含以下量的以下成分：
Figure FDA0003732372350000021
Figure FDA0003732372350000031
17.替代在体力活动期间分解的胶原蛋白的方法，所述方法包括在所述体力活动之后向对其有需要的患者施用根据权利要求1至16中任一项所述的组合物。
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