CN114903046A - Bactericidal composition and application thereof - Google Patents

Bactericidal composition and application thereof Download PDF

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CN114903046A
CN114903046A CN202210553242.8A CN202210553242A CN114903046A CN 114903046 A CN114903046 A CN 114903046A CN 202210553242 A CN202210553242 A CN 202210553242A CN 114903046 A CN114903046 A CN 114903046A
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pyrifenofos
halo
alkyl
radical
alkoxy
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CN114903046B (en
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王军锋
李志念
刘君丽
关爱莹
兰杰
刘长令
孙芹
单忠刚
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention belongs to the field of agricultural bactericides, and particularly relates to a bactericidal composition and application thereof. The composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99: 1; the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof, and the active component B is selected from a bactericide. The bactericidal composition is particularly suitable for preventing and treating various plant pathogenic fungi and bacterial diseases.

Description

Bactericidal composition and application thereof
The application is a divisional application of Chinese invention patent application, the original application date is 11/20/2020, and the application numbers are as follows: 202011314120.0, title of invention: the bactericidal composition and the application thereof have the following publication numbers: CN 112825859A; the applicant filed a divisional application due to the singleness problem pointed out by the examiner of the original application.
Technical Field
The invention belongs to the field of agricultural fungicides, and particularly relates to a pyrimidine-containing substituted pyrazole compound and a bactericidal composition of a fungicide and application thereof.
Background
WO2016184378 discloses a pyrimidine-containing substituted pyrazole compound and application thereof, and reports that the compound shown as the following general formula I-A, I-B has good activity on various diseases.
Figure BDA0003653790080000011
The bactericide of the respiratory inhibitor class, the bactericide of the nucleic acid metabolism inhibitor class, the bactericide of the cell wall synthesis inhibitor class, the bactericide of the signal transduction inhibitor class, the bactericide of the cytoskeleton and the kinetin inhibitor class, the bactericide of the sterol biosynthesis inhibitor class, the bactericide of the phospholipid synthesis inhibitor class, the bactericide of the cell wall synthesis inhibitor class and the bactericide of the methionine biosynthesis inhibitor class are bactericides which are widely used in agricultural production and have outstanding prevention and treatment effects. Due to the single action site, the field efficacy of part of varieties is obviously reduced after long-term repeated use. The multi-site inhibitor bactericide is a broad-spectrum protective bactericide, but the bactericide has poor therapeutic activity and large field dosage.
In the practice of applying bactericides, people often find that one medicament has a good disease prevention effect in the initial stage, but the dosage is gradually increased along with the increase of the use times, the medicament effect is slightly improved, and sometimes the disease prevention effect is even completely lost. The main reason is that the pathogenic bacteria population changes, namely part of pathogenic bacteria obtain drug-resistant plasmids through mutation to generate drug resistance, and the dominant population is gradually formed in natural selection, so that the drug effect of the bactericide is reduced. Meanwhile, it is also recognized that after the pesticide is applied, a part of the pesticide may be scattered on the soil or dissipated into the air, or may flow into rivers and lakes along with rainwater and farmland drainage, causing environmental pollution. Therefore, pesticide products which have high pesticide effect, small dosage and less environmental pollution and can delay the drug resistance of pathogenic bacteria are urgently needed.
The pesticide combination application is an important means for delaying the generation of drug resistance of pathogenic bacteria and is an effective method for reducing the pesticide dosage. The scientificity of the combined application of the bactericides depends on not only the control objects and the action mechanism, but also the combined action property after the medicaments are mixed. Therefore, the development of a high-efficiency bactericide composition with complementary action and remarkable synergism has a plurality of restriction factors and has extremely low success rate.
Disclosure of Invention
The invention aims to provide a synergistic bactericidal composition of a pyrimidine-containing substituted pyrazole compound and a bactericide and application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a bactericidal composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99: 1;
wherein, the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof; the active component B is selected from a bactericide.
The active component A is a compound shown as a general formula I-A or I-B or a salt thereof:
Figure BDA0003653790080000021
in the formula:
R 1 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio radical, C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl radical, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkynyl, C 3 -C 4 Alkenyloxy, halogeno C 3 -C 4 Alkenyloxy radical, C 3 -C 4 Alkynyloxy, halo C 3 -C 4 Alkynyloxy, C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylaminocarbonyl, halogeno C 1 -C 4 Alkylaminocarbonyl radical, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl or C 1 -C 4 Alkylthio group C 1 -C 4 An alkyl group;
R 2 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group;
R 3 selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkynyl, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylsulfinyl, halogeno C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl radical, C 1 -C 4 Alkylaminosulfonyl, di (C) 1 -C 4 Alkyl) aminosulfonyl, C 1 -C 4 Alkylsulfonylaminocarbonyl group, C 1 -C 4 Alkylcarbonylaminosulfonyl radical, C 3 -C 4 Cycloalkyloxycarbonyl radical, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl group, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkyl carbonyl group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylaminocarbonyl, di (C) 1 -C 4 Alkyl) aminocarbonyl, C 2 -C 4 Alkenyloxycarbonyl radical, C 2 -C 4 Alkynyloxycarbonyl group, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylaminosulfenyl, di (C) 1 -C 4 Alkyl) aminosulfanyl, arylcarbonyl C 1 -C 4 Alkyl, arylcarbonyl, aryloxycarbonyl, aryl C 1 -C 4 Alkyloxycarbonyl, aryl C 1 -C 4 Alkyl, heteroaryl carbonyl C 1 -C 4 Alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroaryl C 1 -C 4 Alkyloxycarbonyl or heteroaryl C 1 -C 4 An alkyl group;
R 4 、R 5 can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 4 、R 5 C attached thereto may also form C 3 -C 4 A ring of (a);
R 6 、R 7 can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 6 、R 7 C connected thereto may also form C 3 -C 4 A ring of (a);
R 8 、R 9 can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl, unsubstituted or substituted by 1 to 5R 11 Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;
R 11 selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, C 2 -C 4 Alkenyloxy, halogeno C 2 -C 4 Alkenyloxy radical, C 2 -C 4 Alkynyloxy, halo C 2 -C 4 Alkynyloxy, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl radical, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkyl carbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio carbonyl group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio carbonyl group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylcarbonyloxy, halo C 1 -C 4 Alkylcarbonyloxy, C 1 -C 4 Alkoxycarbonyloxy, halo C 1 -C 4 Alkoxycarbonyloxy, C 1 -C 4 Alkylsulfonyloxy, halo C 1 -C 4 Alkylsulfonyloxy, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkoxy or halo C 1 -C 4 Alkoxy radical C 1 -C 4 An alkoxy group; n is an integer of 0 to 5, and when n is greater than 1, R 11 May be the same or different;
R 14 、R 15 、R 16 or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy or C 3 -C 4 A cycloalkyl group;
w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio or C 1 -C 4 An alkylsulfonyl group;
the salt of the pyrimidine-containing substituted pyrazole compound is a salt formed by a compound shown in a general formula I-A or I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
the active component B is selected from one or more of a respiratory inhibitor bactericide, a nucleic acid metabolism inhibitor bactericide, a cell wall synthesis inhibitor bactericide, a signal transduction inhibitor bactericide, a cytoskeleton and kinetin inhibitor bactericide, a sterol biosynthesis inhibitor bactericide, a phospholipid synthesis inhibitor bactericide, a methionine biosynthesis inhibitor bactericide, a multi-site inhibitor bactericide and an action mechanism unknown bactericide.
When the active component A is a compound in the general formula I-A or a salt thereof, the composition is preferably composed of the active component A and the active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula: r 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r is 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r is 14 、R 15 、R 16 Or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl or C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-A is formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
active component B is selected from flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramide) B43, zoxamide (zoxamide) B44, metalaxyl (metalaxyl) B45, metalaxyl-M B46, ipropamid (iprovalicarb) B47, cymoxanil (cymoxanil) B48, benalaxyl (benalaxyl-M) B49, flusulfamide (flusulfamide) B50, tiadinil (tiadinil) B51, ethaboxam (etham) B52, cyflufenamid (cyflufenamid) B53, cyhexamid (fenhexamide) B53, fenhexamide (fenfluramine) B53, fenfluramine (fenfluramine) B53, diclofenoxapril B53, metoclopramide (ethimide B53), pyrimethanamide (ethiprole) B53, metoclopramide (ethimide B53, metoclopramide (ethiprol) B53, metoclopramide B, Ethiprole (chlorezoline) B70, dimethachlon (dimethachlon) B71, vinclozolin (vinclozolin) B72, diethofencarb (diethofencarb) B73, metrafenone (metrafenone) B74, pyriofenone B75, carbendazim (carbendazim) B76, thiophanate-methyl (thiophanate-methyl) B77, phenamacril (phenracil) B78, benomyl (benomyl) B79, fuberidazole (fuberidazole) B79, thiabendazole (thiabendazole) B79, thiophanate (thionate) B79, pencyron (pencyron) B79, ethazine (acetofenpyrazamide) B79, fenpyrazamide B79, pyribenzofenapyr (fenpyrazamide) B79, pyribenzofenapyr (fenpyrazone) B79, pyrifenoxapridine (fenpyrazamide B79), pyrifenoxadifenozide B79, pyriproxyfen (fenpyrazamide B79), pyriproxyfen (fenpyrazone B79), pyriproxyfen B79, pyriproxyfen (fenpyrazone B79), pyrifenoxadifenox (fenpyrazone B79, pyrifenoxafen) B79, pyriproxyfen (fenpyrazone B79, pyrifenoxafen B79, pyriproxyfen B79, pyrifenoxadifenofen B36fenapyr (fenpyrazone B79, pyrifenoxadifenofen B79, pyrifenoxafen B79, pyriproxyfen (fenpyrazone B79, pyrifenoxadifenofen B36fenapyr (fenpyrazone B79, pyrifenoxafen B79, pyribenzofenapyr (fenpyrazone B79, pyrifenoxafen B36fenoxafen B79, pyrifenoxadifenofen B79, pyribenzofenapyr (fenpyrazone B79, pyribenzofenapyr (fenpropiconazole B79, pyribenzofenapyr (fenpropiconazole B79, pyribenzofenapyr B36fenapyr B79, pyribenzofenapyr B79, pyribenzofena, Dodecamorph (dodemorph) B100, bromuconazole (bromuconazole) B101, imazalil (triaphenonol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumizole) B105, ipfenthifluzole B106, tetrachloronitrobenzene (cinnarizine) B107, chloroneb (chloroneb) B108, niclofenamide (dicloran) B109, biphenyl (biphenyl) B110, edifenphos (edifenphos) B111, terrazole (triconazole) B112, iodopropynyl butylcarbamate (iodocarb) B113, ipropylbenzenes B114, isoprothiolane (isoprothiolane) B115, fluorothiazole (pyriproxyfen) B125, pyriproxyfen B125, pyrithiobac (isoprothiobac) B126, pyrithiobac (isoprothiobac) B123, pyrithiobac (isoprothiobac-methyl pyrifos) B126, pyrithiobac (isoprothiobac) B123, pyriproxyfen B126, pyrifenozide B126, pyriproxyfen B126, pyrifenofos (pyriproxyfen B126, pyrifenofos (pyrifenofos) B126, pyrifenofos (pyrifenofos-p B, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifenofos-p B, pyrifenofos B126, pyrifenofos B, pyrifenofos-p (pyrifenofos-p B, pyrifenofos B126, pyrifenofos-p B, pyrifenofos (pyrifenofos-p B, pyrifenofos-p (pyrifenofos-p B (pyrifenofos-p B, pyrifenofos-p B (pyrifenofos-p B) B (pyrifenofos-p B) B (pyrifenofos B) B (pyrifenofos B126, pyrifenofos B (pyrifenofos-p B (pyrifenofos B) B126, pyrifenofos B) B, pyrifenofos B120, pyrifenofos B126, pyrifenofos B, pyrifenofos-p B, pyrifenofos B (pyrifenofos B126, pyrifenofos B (pyrifenofos-p B (pyrifenofos B126, pyrifenofos-p B126, pyrifenofos B (pyrifenofos-p B, pyrifenofos B (pyrifenofos B, pyrifenofos B120, pyrifenofos B (pyrifenofos B, pyrifenofos B (pyrifeno, Kasugamycin (kasugamycin) B129, mepanipyrim (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptamycin) B132, oxytetracycline (oxytetracycline) B133, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, sodium metbam (nabam) B140, thiothium (emet) B141, metiram (milneb) B142, mancopper (mancopper) B143, furamebic (cunafeneb) B144, sullur (phram) B145, pteridamycin (ptazim) B149, metiram B147, benthiazolium (benthiazolium) B152, benthiazolium (benthiavalicarb) B152, sulfadimidine (sulfadiazine) B151, sulfadiazine B152, sulfadimidine (sulfadiazine B) B152, sulfadiazine B152, sulfadiazinorine (152), sulfadiazine B152, sulfadiazine B150, sulfadiazine B152, fluanib (sulfadiazine B150, fluanib) B150, fluanib (thiamine B152, fluanib) B150, fluanib (thiamine B150, fluanib) B150, fluanib (thiamine B152, fluanib) B150, fluanib (thiamine B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B152, fluanib (sulfamethoxide B152, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B, fluanib (fluanib, fluanib (fluanib) B150, fluanib (fluanib ) B, fluanib, one or more of oxine-copper (oxide-copper) B160, thiodiazole-copper (thiodiazole-copper) B161, nonylomycin (cuppric nonyl phenyl sulfonate) B162, picarbutrazox B163, aminopyrazine B164, metyltetraproprole B165, dodine (dodine) B166, pyridachlomethyl B167, pyridinone (diomerzine) B168, validamycin (validamycin) B169, pyrisoxazone (ferimzone) B170, tebufloquin B171, imidazoxazine (triazoxide) B172, quinofumelin B173, iflumefenoquin B174, dipyritron B175, and teclofluhalam B176.
Further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein the active component A is one or more compounds shown in a general formula I-A or salts thereof;
in the formula, R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r is 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino or halogeno C 1 -C 4 An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r 14 、R 15 、R 16 Or R 17 Can be the sameOr different, respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, tiadinil B51, ethaboxam B52, bupirimate B56, dimethirimol B57, ethirimol B58, hymexazol B58, octhioketone B72, furazolidone B58, fenpropiconazole B58, dimethomone B58, dimethomorph B58, dimethomone B58, dimethomorph B58, metoclopramide B58, thiomorphone B58, thiomorpholinyl-M58, thiomorpholinyl B58, metyl B58, thiomorpholinyl B58, metocloprid B58, and fosinate B58, metyl B58, metocloprid B58, metyl-M B58, metyl-L58, metocloprid B58, metyl B58, metocloprid B58, metyl-M B, Benomyl (benomyl) B79, pyribenzoxim (ethazone) B85, fenamidol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpyrazamine (fenpyrazamine) B90, fluroxypyr (mefenthifluzole) B91, nuarimol (nuarimol) B92, oxpoconazole (oxypyrazole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyriminostrobin (pyriminozole) B97, simeconazole (simeconazole) B104, ipfenpyrazamide B106, pyrifenofos (pyrifenofos) B125, pyrifenofos (pyrifenofos) B126, pyrifenofos (pyrifenofos) B128, pyrifenofos (pyrifenofos) B119, pyrifenofos (pyrifenofos) B124, pyrifenofos (pyrifenofos) B128, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifos) B119, pyrifenofos (pyrifenofos) B125), pyrifenofos (pyrifenofos) B (pyrifenofos) B, pyrifenofos B128, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifenofos) B125, pyrifenofos B, pyrifenofos (pyrifenofos B) B125, pyrifenofos B (pyrifenofos B125, pyrifenofos B119, pyrifenofos B125), pyrifenofos B128, pyrifenofos B125, pyrifenofos B104, pyrifenofos B) B, pyrifenofos B (pyrifenofos B125, pyrifenofos B (pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B (pyrifenofos B) B123, pyrifenofos B125, pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B (pyrifenofos B125, pyrifenofos B119, pyrifenofos B123, pyrifenofos B125, pyrifenofos B (pyrifenofos B123, pyrifenofos B) B, pyrifenofos B125, pyrifenofos B123, pyrifenofos B (pyrifenofos B, pyrifenofos B125, pyrifenofos B (pyrifenofos B, pyrifenofos B (pyrifenofos B125, pyrifenofos B (pyrifenofos B, pyrifenofos B119, pyrifenofos B (pyrifenofos B, pyrifenofos B125, pyrifenofos B (pyrifenofos B119, pyrifenofos B (pyri, Kasugamycin (kasugamycin) B129, mepanipyrim (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, metiram (milneb) B142, mancopper (mancoppper) B143, sulfur (sulpholur) B145, dichlofluanid (anilazine) B146, captan (captan) B147, chlorothalonil (chlorothalonil) B149, benflumethamine (dichlorfluanid) B150, tolylfluanid (carbozide) B167, thionochloride B161, thionocathimide B161, thionocathione (thionocathiazole) B163, thionocathiazole B163, thionocathione (thionocathione) B165, thionocathione B163, thionocathion B154, thionocathione B171, thionocathion B163, thionocathione B154, thionocathion B171, thionine B154, thionocathion B170, thionocathione B170, thionocathion B170, thionine B170, thionocathion B170, thionocathione B170, thionocathion B, thionocathione B, thionine B170, thionine B, thionocathione B, thionine B and thionine B170, thionine B and thionine B (thionine B, thionine B (thionine B, thionine, One or more of ipflufenoquin B174, dipyrometron B175 and teclofthalam B176.
Still further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula, R 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r 14 、R 15 、R 16 Or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro or C 1 -C 4 An alkyl group; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramid) B43, zoxamide (zoxamide) B44, metalaxyl-M (metalaxyl-M) B46, ipropamid (iprovalicarb) B47, cymoxanil (cymoxanil) B48, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, bupirimate (bupirimate) B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinidone (chinomethiazide) B60, flufenapyr (fenpyr) B60, fenpropiconazole (fenpyrazamide) B60, pyrimethanamide (fenpyraclostrobin B60), pyrimethanamide (60), pyrimethanil) B60, pyrimethanil B60, fenapyr (60, fenpropiconazole) B60, fenapyr B60, fenpropiconazole B60, fenapyr (60, fenapyr B36fenapyr B60, fenapyr B36fenoxapyroxapyr B60, fenapyr B36fenapyr B60, fenapyr B36fenoxapyr B60, fenapyr B36fenoxapyr B60, fenapyr B60, fenpyr B36fenoxapyr B60, fenpyr B36fenoxapyr B60, fenpyr B36fenoxapyr B60, fenpyr B36fenoxapyr B, fenpyr B60, fen, Simeconazole B104, iprifluorafluozole B106, iprobenfos B114, isoprothiolane B115, oxathidiazuron B116, fluxaprop B117, propamocarb B118, quintozene B121, tolclofos B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinamide B125, pyrimorph (pyrimorph) B126, pyrimorph B125, pyrimorph (pyrimorph) B126, cyprodinil B128, kasugamycin B129, pyrimethanil B149, pyrimethanil B156, pyrimethanil B150, pyrimethanil B155, pyrimethanil B145, pyrimethanil B134, pyrimethanil B150, pyrimethanil B134, pyrimethanil B137, pyrimethanil B129, pyrimethanil B150, pyrimethanil B134, pyrimethanil B150, pyrimethanil B (pyrimethanil B) B150, pyrimethanil B (pyrimethanil B) B, pyrimethanil B150, pyrimethanil B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensul B) B (bensulbensul B (bensul B) B (bensul B) B (bensulbensulbensul B) B (bensul B (bensulbensulbensulbensul B) B (bensulbensulbensul B) B (bensulbensul B) B (bensulbensulbensul B (bensulbensul B (bensul B) B (bensulbensul B) B (bensul B) B (bensul B (bensulbensul B (bensul B) B (bensul B (bensulbensul B) B (bensul B) B (bensul, One or more of cuppric nonyl phenyl sulfonate B162, picarbtrazol B163, aminopyrifen B164, metyltetrapole B165, pyridachlomethyl B167, validamycin (validamycin) B169, tebufloquin B171, quinofumelin B173, iflumenoquin B174, dipyrometrone B175, and teclofthalam B176.
When the active component A is a compound in the general formula I-B or a salt thereof, the composition is preferably composed of the active component A and the active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio radical, C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl radical, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl or halo C 2 -C 4 An alkynyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-B is formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from the group consisting of dinocap B40, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B45, mefenoxam B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, flusulfamide B50, tiadinil B51, ethaboxam B52, cyflufenamid B52, cyhalothrimide B52, metoclopramide B52, metoclopramide B52, metoclopramide B, metconazole B69, dichlozoline B70, dimethachlon B71, dichlozoline B72, diethofencarb B73, metrafenone B74, pyriofenone B75, carbendazim B76, thiophanate-methyl B77, cyanophenamide B78, benomyl B78, fuberidazole B78, thiabendazole B78, fenpyrazamide B78, penfenpyrazofenamide B78, fenpyrazamide B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyraclostrobin B78, fenpyra, Triazine (triforine) B99, dodemorph (dodemorph) B100, bromuconazole (broconazol) B101, imazalil (triphenol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumizole) B105, ifetrobrifluconate B106, tetrachloronitrobenzene (tecnazole) B107, chloroneb (chloroneb) B108, niclosamide (dicloran) B109, biphenyl (biphenyl) B110, diphenoxyphos (edifenphos) B111, terrazolin (etridiazol) B112, iodopropynyl butylcarbamate (iodocarb) B113, iprobenfonin (ipulofos) B114, isoprothiolane (isoprothiolane) B115, pyriproxyfen B125, pyrithiobac (pyrifos) B125, pyrifenofos (pyrifos) B123, pyrithiobac (pyrifos) B126, pyrithiobac (pyrifos) B126, pyriproxyfen B126, pyrifos (pyrifos) B126, pyrifos (pyrifos B126, pyrifos (pyrifos) B126, pyrifos (pyributin B126, pyrifos (pyrifos) B126, pyrifos (pyrifos B120, pyrifos B, pyrifos (pyrifos B120, pyrifos B, pyrifos (pyrifos) B, pyrifos (pyrifos) B120, pyrifos (pyrifos) B, pyrifos (pyrifos) B126, pyrifos (pyrifos) B, pyrifos (pyrifos B) B120, pyrifos B126, pyrifos B, pyrifos (pyrifos B126, pyrifos B (pyrifos B, pyrifos B126, pyrifos (pyributin B) B, pyrifos B (pyrifos B, pyrifos B120, pyrifos B) B (pyrifos B126, pyributin B126, pyrifos B, pyributin B (pyrifos B120, pyrifos B126, pyrifos B126, pyributin B120, pyrifos B126, pyributin B126, pyrifos B (pyributin B, pyrifos B (pyrifos B, pyrifos B120, pyributin B126, pyributin B, pyrifos B120, pyributin B) B, pyrifos B104, pyributin B (pyributin B, pyrifos B (pyributin B (pyrifos B (pyributin B, pyributin B104, pyributin B (pyrifos B104, pyrifos B (pyrifos B104, pyrifos B104B (pyrifos B (pyributin B (pyrifos B104, pyrifos B (pyri, Cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, mepanipyrim (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptamycin) B132, oxytetracycline (oxytetracycline) B133, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, ambam (amobam) B139, sodium (nabam) B140, thiometem (etem) B141, metiram (neb) B142, mancozeb (mancopper) B143, furametpyr B144, thioflavin (phrophthal) B149, milphos (neb) B147, sulfadimidine (sulfadimidine) B151, sulfadimidine (sulfadiazine) B152, sulfadimidine (sulfadimidine B) B150, sulfadimidine (sulfadiazine B) B152, sulfadimidine B (152), fluazulene B) B150, sulfadiazine B152, sulfadiazine B150, sulfadimidine B (sulfadimidine B) B150, sulfadimidine B152, sulfadimidine B150, fluanidine B150, sulfadimidine B (sulfadimidine B) B152, fluanidine B150, fluanidine B (sulfadimidine B) B150, fluanidine B (sulfadimidine B) B150, fluanidine B (sulfadimidine B) B150, fluanidine B152, fluanidine B150, fluanidine B (fluanib) B (fluanib) B (fluanib) B150, fluanib) B152, fluanib (fluanib) B150, fluanib (fluanib) B152, fluanib (fluanib) B152, fluanib (fluanib) B152, fluanib) B150, fluanib (fluanib) B152, fluanib) B150, fluanib (fluanib) B150, fluanib (fluanib) B150, fluanib (fluanib) B (fluanib) B150, fluanib (fluanib) B150, fluanib (flu, Zinc thiazole (thiazole) B159, oxine-copper (epoxide) B160, thiodiazole-copper (thiodiazole-copper) B161, nonylocete (cuppric nonylphenol sulfonate) B162, picarbuzox B163, aminopyrofen B164, metyltetraprop B165, dodine (done) B166, pyridachlomethyl B167, pyridinone (diclomezine) B168, validamycin (validamycin) B169, pyriminohydrazone (ferazone) B170, tebufloquin B171, triazoxide (triazoxide) B172, quinofumelilin B173, ipflufenoquin B174, dimetithron B175, and teclolam B176.
Further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 Alkynyl; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halogeno C 1 -C 4 An alkoxycarbonyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino or halogeno C 1 -C 4 An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-B is formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxad (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrazamide (flupyrazam) B5, flubeneramide (flubeneram) B6, sedaxane (sedaxane) B7, fluthiavalicarb (penthiopyrad) B8, boscalid (boscalid) B9, diphenpyrad (bixafen) B10, flutolanilide (flutolanil) B10, furflupyrazamide (furametpyr) B10, thifluzamide (thifluzamide) B10, flufenpyrazamide (diflufenpyrazamide) B10, flufenpyrafluzamide B10, flufenazamide B10, flufenacetoamide B10, flufenamidoxime B10, flufenamide B10, flufenamidofen B10, flufenamide B10, flufenamidofen B10, flufenamide B10, flufenamidofen B10, flufenamide B, Amisulbrom (amisulbrom) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramid) B43, zoxamide (zoxamide) B44, mefenoxam (metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cyanamide (momoxamonil) B48, benalaxyl (benaxyl-M) B48, tiadinil (tiadinil) B48, ethaboxam (ethanamizol) B48, ethirimol sulfonate (bupirimate) B48, dimethyphenol (dimethomorph) B72, silthiofam (silthiopham) B48, metoclopramide (ethiofenpyrone) B48, metoclopramide (ethiofenprox) B48, metoclopramide B36ethiofenprox B48, metoclopramide B36difenoconazole B48, metoclopramide B48, metoclopramide B36difenoconazole B, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B, thiophanate-methyl B77, phenamacril B78, benomyl B79, pyrifenoxime B85, fenamidol B86, fenbuconazole B87, fenpropidin B88, fenpyrazamine B90, fluroxypyr B91, nuarimol B92, oxpoconazole B93, pefurazoate B94, prochloraz B3, spiroxamine B96, pyriproxyfen B46120, pyrifenoxathiofamid B115, pyrifenoxathiofamid B124, pyrifenoxathiofam B108, pyrifenoxathiofamid B115, pyrifenoxathiofamid B124, pyrifenofos B123, pyrifenofos B121, pyrifenoxathiofamid B108, pyrifenoxathiofamid B124, pyrifenoxathiofamid B123, pyrifenoxathiofamid B124, pyrifenofos B123, pyrifenofos B124, pyrifenofos B123, pyrifenothiofam B124, pyrifenothiofam B123, pyrifenothiofamid B124, pyrifenothiofamid B104, pyrifenothiofamid B123, pyrifenofos, pyrifenothiofamid B123, pyrifenothiofamid B, pyrifenofos B, pyrifenothiofamid B123, pyrifenothiofamid B, pyrifenofos, pyrifenothiofamid B123, pyrifenothiofamid B, pyrifenothiofam B, pyrifenothiofamid B124, pyrifenothiofam B, pyrifenothiofamid B, pyrifenothiofam B124, pyrifenofos B123, pyrifenofos B, pyrifenothiofam B, pyrifenothiofamid B124, pyrifenothiofamid B123, pyrifenofos B, pyrifenothiofamid B124, pyrifenothiofamid B, pyrifenofos B, pyrifenothiofam B, pyrifenothiofamid B, pyrifenothiofam B, pyrifenothiofamid B124, pyrifenothiofam B124, pyrifenothiofamid B124, pyrifenothiofam B123, pyrifenofos B, pyrifenothiofamid B123, pyrifenothiofamid B, pyrifenothiofam B, pyrifenothiofamid B, pyrifenofos, pyrifenothiofamid B, pyrifenothiofam B, pyrifenothiofamid B124, pyrifenofos, pyrifenothiofam B, pyrifenofos, pyrifenothiofamid B, pyrifenothiofam B, pyrifenothiofamid, Valienamine B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, ambam B139, mancozeb B142, manocopper B143, sulpiride B145, trichloram B146, captoprene B147, carboline B156, carboline B162, carboline B154, carboline B150, carboline B154, carboline B150, carboline B, carboline B, one or more of pyridachloromethyl B167, validamycin B169, pyrizonone B170, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175 and teclofthalam B176.
Still further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C 1 -C 4 An alkyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C 1 -C 4 An alkyl group; r 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r is 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxafen (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyrazam) B5, fluorophenyletheramide (flubentiam) B6, sedaxane (sedaxane) B7, penthiopyrad (penthiopyrad) B7, boscalid (boscalid) B7, bispyramid (bixafen) B7, thifluzamide (thifluzamide) B7, fluxapyroxamide (pyflutolofen) B7, fluazinam (pydiflufenpyrad) B7, fluazimide (fluquinconazole) B7, flufenamidopropyl flufenamide (flufenamidopropyl flufenamide) B7, flufenamidone (flufenamide B7), flufenamidone (flufenamid B7), flufenamid B7, flufenamidone B7, flufenamid B, Zoxamide (zoxamide) B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, tiadinil B51, ethaboxam (ethaboxam) B52, bupirimate B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinazone (chinomethionat) B62, fludioxonil (fludioxonil) B65, iprodione (iprodione) B67, procymidone (procymidone) B68, diethofenfafenib B2, metrafilone (metryxol) B56, isophthora pirillum (iprodione) B91, isoprothiolane B3676, isoprothiolane (isophthora B) B91, isophthora B3676, isophthora B3676, isoprothiolane (isophthora B) B91, isoprothiolane B3676, isophthora B3676, isophthora piririmod B3676, isophthora B3676, isophthora pirillon (isophthora B3676, isophthora pirillum (isophthora B36fenoxadifenofos, isophthora B3676, isoprothiolane (isophthora B3676, isoprothiolane (isophthora B36fenoxadifenofos, isophthora B3676, isoprothiolane, isophthora B3676, isophthora B36fenoxadifenofos, isoprothiolane (isophthora B36fenoxadifenofos, isophthora B3676, isoprothiolane (isophthora B, isophthora B3676, isoprothiolane (isophthora B3676, isophthora B36fenoxadifenofos, isophthora B3676, flupyr (isophthora B, isophthora B36fenoxadifenom, isophthora B3676, flupyr, isophthora B36fenoxadifenom, isophthora B3676, isophthora B, flupyr (isophthora B, isophthora B3676, isophthora B, flupyr, isophthora B3676, isophthora B36fenoxadifenom, isophthora B, isophth, Fluothiazole pyriproxyfen B116, fluxapriroline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B149, propiconazole B160, pyrimethanil B161, pyrimethanil B162, pyrimethanil B150, pyrimethanil B162, pyrimethanil B150, pyrimethanil B150, pyrimethanil B (bencarb B, pyrimethanil B (bencarb B (bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbencarb B, pyrimethanil B (bensulben B (ben B (bencarb B (bensulben B, pyrimethanil B (ben B, pyrimethanil B (bensulbensulben B, pyrimethanil B (ben B (bensulben B, pyrimethanil B (ben B, pyrimethanil B (bensulben B (ben B (bencarb B, pyrimethanil, One or more of pyridachlorometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175, and teclofthalam B176.
Application of bactericidal composition in preparation of medicines for preventing and treating plant pathogenic fungi and bacterial diseases
The plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, leaf mold, banded sclerotial blight, damping off, black nevus, smut, powdery mildew, downy mildew, late blight, epidemic disease, downy mildew, black shank, soft rot, damping-off, phytophthora blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, gummy stem blight, gray mold, sclerotinia, rot, root rot, gibberellic disease, soft rot, bacterial blight, leaf blight, angular leaf spot, circular leaf spot, bacterial leaf blight, bacterial wilt, ulcer disease or yellow dragon disease.
The bactericidal preparation comprises the effective component of the bactericidal composition, and the weight percentage of the bactericidal composition is 0.1-95%.
The composition of the present invention is used at a concentration of 5 to 500mg/L (content of active ingredient, the same shall apply hereinafter) in the area where crops are grown, preferably 50 to 200mg/L, depending on the degree of occurrence of crop diseases.
The active component A and at least one active component B in the composition are prepared in advance or prepared at the use site or the two components are separately and sequentially used according to a proper proportion provided by the invention.
The composition is suitable for the application of trees (apples, rubber, pears, oranges, hawthorns, chestnuts, pepper, medlar, mangoes, pawpaw, lychees, bananas, peach trees and the like), vine plants (grapes and the like), cucurbits (tomatoes, eggplants, hot peppers, cucumbers, melons, white gourds, watermelons, pumpkins, balsam pears, luffa, chayords, cucurbits, pumpkin, lettuce, potatoes and carrots), beans (peas, beans and cowpeas), cereals (wheat, rice, corns, sorghum and the like), oil crops (rapes, soybeans, peanuts, sesames and the like), onions and garlics (shallots, garlic and onions), economic crops (tobaccos and the like), fungal and bacterial diseases control of flower plants and lawns, seed treatment, fruit preservation and the like.
The bactericidal composition is particularly suitable for preventing and treating the following plant diseases: apple powdery mildew, rubber powdery mildew, citrus powdery mildew, hawthorn powdery mildew, Chinese chestnut powdery mildew, pepper powdery mildew, medlar powdery mildew, mango powdery mildew, papaya powdery mildew, club head powdery mildew, grape powdery mildew, tomato powdery mildew, eggplant powdery mildew, pepper powdery mildew, cucumber powdery mildew, melon powdery mildew, wax gourd powdery mildew, watermelon powdery mildew, pumpkin powdery mildew, balsam pear powdery mildew, towel gourd powdery mildew, cucurbit powdery mildew, pumpkin powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew, wheat powdery mildew, barley powdery mildew, Chinese rose powdery mildew, chrysanthemum powdery mildew, lawn grass powdery mildew, carrot powdery mildew, apple rust, pear rust, soybean rust, pea rust, bean rust, cowpea rust, wheat rust, barley rust, corn rust, onion rust, Chinese cabbage rust, Chinese wolfberry powdery mildew, mango rust, grape powdery mildew, tomato powdery mildew, cucumber powdery mildew, tomato powdery mildew, cucumber powdery mildew, powdery mildew, cucumber powdery mildew, cucumber powdery mildew, powdery mildew, Garlic rust, onion rust, turf grass rust, apple anthracnose, rubber tree anthracnose, pear anthracnose, citrus anthracnose, hawthorn anthracnose, Chinese chestnut anthracnose, Chinese prickly ash anthracnose, Chinese wolfberry anthracnose, mango anthracnose, papaya anthracnose, hazel anthracnose, grape anthracnose, tomato anthracnose, eggplant anthracnose, hot pepper anthracnose, melon anthracnose, white gourd anthracnose, watermelon anthracnose, pumpkin anthracnose, bitter gourd anthracnose, towel gourd anthracnose, chayote anthracnose, cucurbit, pumpkin anthracnose, lettuce anthracnose, cucumber downy mildew, grape downy mildew, melon downy mildew, balsam pear downy mildew, towel gourd downy mildew, tomato late blight, potato late blight, pepper blight, cucumber damping-off, eggplant damping-off, pepper damping-off, pear brown spot, cucumber brown spot, pear black spot, rose black spot, pear black spot, pepper anthracnose, grape anthracnose, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow leaf spot, tomato yellow pepper yellow leaf spot, tomato yellow leaf spot, tomato leaf spot, rose black spot, chrysanthemum black spot, soybean brown spot, cowpea red spot, apple alternaria leaf spot, kidney bean round spot, eggplant rod spore leaf spot, potato black nevus, wheat sharp eyespot, rice sheath blight, rice bakanae disease, soybean damping off, pea damping off, kidney bean damping off, onion damping off, turf grass damping off, citrus canker, citrus yellow shoot, rice bacterial leaf blight, rice bacterial streak, tomato bacterial wilt, cucumber bacterial angular leaf spot, and crop gray mold and sclerotinia rot caused by botrytis and sclerotinia pathogenic bacteria.
The invention has the advantages that:
the invention combines the active component A and the bactericide active component B according to different proportions, the observation effect is larger than the calculation effect, the synergistic effect is very obvious, the dosage of the medicament can be reduced, and the environmental pollution is reduced. The bactericide with different action mechanisms is mixed, which is beneficial to delaying the generation of drug resistance of pathogenic bacteria, provides an effective solution for the problem of bactericide resistance in agricultural production and pesticide industry, and prolongs the service life of the bactericide.
Detailed Description
The synergistic effect of the compositions according to the invention on harmful fungal and bacterial diseases is further illustrated by the following examples, to which the invention is in no way restricted. Wherein the active components are the compound A and the bactericide B in the bactericidal composition;
the preparation of the compound A is described in WO2016184378, and the bactericide B is one or more of respiratory inhibitor bactericide, nucleic acid metabolism inhibitor bactericide, cell wall synthesis inhibitor bactericide, signal transduction inhibitor bactericide, cytoskeleton and kinetin inhibitor bactericide, sterol biosynthesis inhibitor bactericide, phospholipid synthesis inhibitor bactericide, cell wall synthesis inhibitor bactericide, methionine biosynthesis inhibitor bactericide, multi-site inhibitor bactericide, and bactericide with unknown action mechanism.
The test method and the evaluation method are as follows:
the active samples to be detected are respectively active component A, active component B, and the composition of active component A and active component B.
The active component A is one or more of active component A1, active component A2, active component A3 and active component A4;
wherein the active component A1 is a compound A1 shown in a general formula I-A;
the active component A2 is a salt formed from compound A1 and sulfuric acid;
compound A1 is
Figure BDA0003653790080000091
In the formula, R 3 Selected from hydrogen, R 4 、R 5 Are each selected from hydrogen, R 6 、R 7 Are each selected from hydrogen, R 8 、R 9 Are each selected from hydrogen, R 11 Selected from 4-chloro, n ═ 1, R 14 、R 15 、R 16 Or R 17 Are respectively selected from hydrogen, W is selected from hydrogen, namely the compound A1;
the active component A3 is a compound A3 shown in a general formula I-B;
active ingredient a4 is a salt formed from compound A3 and sulfuric acid:
compound A3 is
Figure BDA0003653790080000101
In the formula:
R 1 selected from difluoromethyl, R 2 Selected from chlorine, R 3 Selected from hydrogen, R 4 、R 5 Are each selected from hydrogen, R 6 、R 7 Are each selected from hydrogen, R 8 、R 9 Are each selected from hydrogen, R 11 Is selected from 4-chlorine, W is selected from hydrogen, namely the compound A3.
The active component B is benzovindiflupyr B1, fluxapyroxamide B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxamide B14, fluopyram B27, ametoctradin B31, fluazinam B32, fenpicoxamide B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, phenamacystron B78, fluroxypyr B91, prochloraz B95, fluthiazopyr B116, pyfluxaprop-roline B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B149, propineb B137, propineb B163, propineb B159, propiconazole B159, prothioconazole B159, etc.
The composition to be detected is active component A1, each active component B, active component A1 and each active component B respectively; wherein the active component B is a composition consisting of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctrad B31, fluazinam B32, fenpicoamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, phenamacystron B78, fluroxypyr B91, prochloraz B95, fluthiazopyr B116, fluxaprop-iprole B117, polyoxin B124, kasugamycin B129, zinokinomycin B149, mancozeb B137, propineb B163, propineb B159, and propineb B159.
The composition to be detected is a composition which consists of an active component A2 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhaloxate B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxatradine B117, doxicap B124, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The composition to be detected is a composition which consists of an active component A3 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhaloxate B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxatradine B117, doxicap B124, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The composition to be detected is a composition which consists of an active component A4 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhaloxate B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxatradine B117, doxicap B124, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The specific mode is as follows:
dissolving the above active components or compositions in acetone (volume ratio of acetone amount to liquid spray amount is equal to or less than 0.05), diluting with water containing 0.1% Tween 80 to obtain solution to be tested with desired concentration, and preparing the solution to be tested according to a set proportion. The solution to be tested is sprayed on neat and uniform host plants (which are not inoculated before pesticide application and are not used with other medicines) cultured in a greenhouse on a crop sprayer, and disease inoculation is carried out 24 hours later. According to the characteristics of diseases, inoculating the disease plants to be cultured by temperature and moisture control, culturing in a climatic chamber, and transferring into a greenhouse for culturing after the diseases are infected; the disease plants which do not need to be subjected to moisturizing culture are inoculated and then directly transferred into a greenhouse for culture. And (5) after the disease is fully developed, carrying out disease investigation, and recording the total leaf number, the diseased leaf number and the disease grade number of the investigation.
The disease grading method comprises the following steps:
level 0: the whole plant is disease-free;
level 1: the area of the lesion spots is less than 5% of the whole leaf area;
and 3, level: the area of the lesion spots is 6-10% of the whole leaf area;
and 5, stage: the area of the whole leaf of the lesion spot is 11-20%;
and 7, stage: the area of the lesion spots is 21-50% of the whole leaf area;
and 9, stage: the area of the lesion spots is more than 51 percent of the whole leaf area.
Observed efficacy of active ingredients or compositions (C) obs ) Using a general formula for pesticide effect evaluation (a correction control effect calculation formula) to calculate:
Figure BDA0003653790080000111
Figure BDA0003653790080000112
an efficacy of "0" indicates that the level of infestation of the treated crop is the same as the level of infestation of the untreated control crop; an efficacy of "100" indicates that the treated crop is not infested.
Expected efficacy of the composition (C) exp ) Using Abbott's method (see Liu Ching et al, germicide)Synergistic effect of mixed application, pesticide science and management, 2002, 23(5), 12-15).
C exp ＝X+Y–XY/100
In the formula:
x: the efficacy of active ingredient a at the concentration a used;
y: the efficacy of active component B at concentration B is used.
Observed efficacy of synergistic Effect of compositions (C) obs ) And expected efficacy (C) exp ) And (4) evaluating the ratio of (A) to (B). Ratio (synergy ratio)>1, the composition exhibits a synergistic effect; when the ratio (synergy ratio) is 1, the composition shows an additive effect; ratio (synergy ratio)<1, indicating that the composition is antagonistic.
Example 1 control of cucumber powdery mildew test 1
Spraying aqueous solution (effective component concentration is shown in the following table) of each active component or composition on potted cucumber seedlings of two-leaf stage of Jinzhan-4 variety, spraying spores of Ustilago virens on leaves after 24 hours, culturing in a greenhouse, and performing disease investigation after 10 days and full control disease.
The activity data and the synergistic effect of the individual active components and the composition of the invention for controlling cucumber powdery mildew are shown in tables 1 and 2.
The results in Table 2 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on cucumber powdery mildew in a test proportioning range.
TABLE 1 Activity of the Individual active ingredients
Figure BDA0003653790080000113
Figure BDA0003653790080000121
TABLE 2 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000122
Figure BDA0003653790080000131
Figure BDA0003653790080000141
Example 2 control of cucumber powdery mildew test 2
The seedling of the potted cucumber with the variety of 'Xintai Mici' at the two-leaf stage is sprayed with aqueous solution (the concentration of active ingredients is shown in the table below) of each active component or composition, after 24 hours, the spores of the yellow-white powdery mildew germs are sprayed on the leaves by using an adaptor and cultured in a greenhouse, and after 10 days, disease investigation is carried out after full control attack.
The activity data and the synergistic effect of the individual active components and the composition of the invention for controlling cucumber powdery mildew are shown in tables 3 and 4.
The results in Table 4 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on cucumber powdery mildew in a test proportioning range.
TABLE 3 Activity of the Individual active Components
Figure BDA0003653790080000142
TABLE 4 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000143
Figure BDA0003653790080000151
Example 3 test for controlling powdery mildew of melon
Potted four-leaf sweet melon seedlings (1-2 leaves are cut off before the test and only 3-4 leaves are reserved) of the variety 'sweet melon' are sprayed with aqueous solutions (the concentration is shown in the table below) of various active components or compositions, after 24 hours, the spore suspension of the powdery mildew of the melon is inoculated on the leaves and cultured in a greenhouse, and after 15 days, disease investigation is carried out after the control is fully developed.
The activity data of the individual active ingredients of the invention for controlling powdery mildew of melon are shown in table 5.
The activity data and the synergistic effect of the composition for preventing and treating powdery mildew of melons are shown in table 6.
The results in Table 6 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on the powdery mildew of melons in a test proportioning range.
TABLE 5 Activity of the Individual active Components
Figure BDA0003653790080000152
Figure BDA0003653790080000161
TABLE 6 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000162
Example 4 test for controlling powdery mildew of Capsicum
Spraying the potted six-leaf stage pepper seedlings of 'green round pepper' with aqueous solutions (effective component concentrations are shown in the following table) of active components or compositions, inoculating pepper powdery mildew spores on the back surfaces of the leaves after 24 hours, culturing in a climate chamber, transplanting the leaves into a greenhouse for culturing after the diseases are infected, and performing disease investigation after the diseases are fully developed in contrast after 20-25 days.
The activity data of each individual active component for controlling powdery mildew of pepper of the invention are shown in tables 7 and 8.
The activity data and synergistic effect of the composition of the invention for controlling powdery mildew of capsicum are shown in tables 9 and 10.
The results in tables 9 and 10 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on pepper powdery mildew in a test proportioning range.
TABLE 7 Activity of the Individual active Components
Figure BDA0003653790080000171
TABLE 8 Activity of the Individual active Components
Figure BDA0003653790080000172
TABLE 9 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000173
TABLE 10 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000181
Example 5 test for controlling powdery mildew of beans
Spraying aqueous solution (effective component concentration shown in the following table) of active components or compositions on potted two-leaf kidney bean seedling of Fenggao No. 1, air drying naturally after spraying, and suspending spore water suspension (5 × 10) of pathogenic bacteria of powdery mildew of kidney bean for 24 hr 6 Individual/ml) on the leaf of kidney bean, naturally drying, transferring into a greenhouse for culture, and culturing under the conditions (temperature: day 23-28 deg.C, night 18-20 deg.C, waiting for the pairAfter the disease is fully developed, the disease condition is investigated.
The activity data of the individual active ingredients of the invention for controlling powdery mildew of kidney beans are shown in table 11.
The activity data and synergistic effect of the composition of the invention for preventing and treating powdery mildew of kidney beans are shown in Table 12.
The results in Table 12 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on the powdery mildew of kidney beans in a test proportioning range.
TABLE 11 Activity of the Individual active Components
Figure BDA0003653790080000182
TABLE 12 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000183
Figure BDA0003653790080000191
Example 6 tobacco powdery mildew control test
The tobacco seedling in six-leaf period cultivated in a pot of variety CN89 is treated by spraying with aqueous solution (concentration is shown in the table below) of each active component or composition, after 24 hours, the tobacco powdery mildew spore suspension is inoculated on the tobacco seedling leaf, and is directly transplanted into a greenhouse for culture, and after 20 days, disease condition investigation is carried out after full control disease.
The activity data of the individual active ingredients of the invention for controlling tobacco powdery mildew are shown in table 13.
The activity data and synergistic effect of the composition of the invention for preventing and treating powdery mildew of tobacco are shown in Table 14.
The results in Table 14 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition is shown to be matched in the range of the experimental mixture ratioThe powdery mildew of tobacco shows synergistic effect.
TABLE 13 Activity of the Individual active Components
Figure BDA0003653790080000192
TABLE 14 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000201
Example 7 corn rust control test
Spraying the potted two-leaf corn seedlings of the variety 'golden yellow glutinous' with aqueous solutions (the concentration of active ingredients is shown in the following table) of the active components or the compositions, inoculating the corn rust germ spore suspension on the corn leaves after 24 hours, culturing in a climatic chamber, transferring the corn rust germ spore suspension into a greenhouse for culturing after the infection of diseases is finished, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data of the activity of the individual active ingredients of the invention against corn rust are shown in table 15.
The activity data and synergistic effect of the composition of the invention for controlling corn rust are shown in table 16.
The results in Table 16 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on the corn rust in a test mixture ratio range.
TABLE 15 Activity of the Individual active Components
Figure BDA0003653790080000202
Figure BDA0003653790080000211
TABLE 16 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000212
Figure BDA0003653790080000221
Example 8 control of cucumber downy mildew test 1
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data on the activity of the individual active ingredients according to the invention for controlling cucumber downy mildew are given in table 17.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in Table 18.
The results in table 18 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 17 Activity of the Individual active Components
Figure BDA0003653790080000222
TABLE 18 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000223
Figure BDA0003653790080000231
Figure BDA0003653790080000241
Figure BDA0003653790080000251
Example 9 control of cucumber downy mildew test 2
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 19.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in table 20.
The results in table 20 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 19 Activity of the Individual active Components
Figure BDA0003653790080000252
TABLE 20 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000253
Figure BDA0003653790080000261
Figure BDA0003653790080000271
Figure BDA0003653790080000281
Example 10 control of cucumber downy mildew test 3
The test is carried out according to the national standard GB/T17980.26-2000: pesticide field efficacy test guidelines (I) -related content execution of the bactericide for controlling cucumber downy mildew. The test site is arranged in Bayizhen protected area of Suzhongyuan region of Shenyang city, the cucumber variety is Sinomei thorn, the management level is middle, during the test, the cucumber is in the cucumber forming period, downy mildew slightly occurs, and the area of the cell is about 25m 2 (ii) a Carrying out medicament spraying treatment on the cucumbers according to the set dosage of the experiment; the test is carried out for 2 times, the application intervals are 7 days, and the attack condition of cucumber downy mildew in each cell is investigated 10 days after the second application. Sampling is carried out at 4 points in each cell, 8 plants are taken at each point, and the disease condition of the whole plant leaf is investigated from top to bottom of each plant.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 21.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in Table 22.
The results in table 22 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 21 Activity of the Individual active Components
Figure BDA0003653790080000282
TABLE 22 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000283
Figure BDA0003653790080000291
Example 11 control of cucumber downy mildew test 4
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 23.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in Table 24.
The results in table 24 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 23 Activity of the Individual active Components
Figure BDA0003653790080000292
TABLE 24 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000301
Example 12 control of grape downy mildew test 1
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in Table 25.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in Table 26.
The results in Table 26 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 25 Activity of Individual active Components
Figure BDA0003653790080000302
Figure BDA0003653790080000311
TABLE 26 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000312
Figure BDA0003653790080000321
Example 13 control of grape downy mildew test 2
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients according to the invention against grape downy mildew are given in Table 27.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in Table 28.
The results in Table 28 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 27 Activity of Individual active Components
Figure BDA0003653790080000322
Figure BDA0003653790080000331
TABLE 28 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000332
Figure BDA0003653790080000341
Example 14 control of grape downy mildew test 3
The method comprises the steps of carrying out spray treatment on potted five-leaf grape seedlings of 'seedless white heart' varieties by using aqueous solutions (effective component concentrations are shown in the table below) of active components or compositions, inoculating grape downy mildew pathogen sporangium suspension on grape leaves after 24 hours, placing the grape seedlings in a climatic chamber for culture, moving the grape seedlings into a greenhouse for culture after diseases are infected, and carrying out disease investigation after 7 days and full control attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in table 29.
The activity data and synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 30.
The results in Table 30 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 29 Activity of the Individual active Components
Figure BDA0003653790080000342
Figure BDA0003653790080000351
TABLE 30 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000352
Figure BDA0003653790080000361
Example 15 control of grape downy mildew test 4
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in table 31.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in table 32.
The results in Table 32 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 31 Activity of Individual active Components
Figure BDA0003653790080000362
TABLE 32 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000363
Figure BDA0003653790080000371
Example 16 control of Chinese cabbage downy mildew test
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf Chinese cabbage seedling of 'four-season Chinese cabbage', inoculating peronospora pelagi sporangium on the back of leaf after 24 hours, culturing in climate chamber, culturing in greenhouse after infection of disease is completed, and performing disease investigation after disease is fully developed in contrast after 5-7 days.
The activity data of each single active component for preventing and treating the Chinese cabbage downy mildew is shown in a table 33.
The activity data and the synergistic effect of the composition for preventing and treating Chinese cabbage downy mildew are shown in Table 34.
The results in Table 34 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on the cabbage downy mildew in a test proportioning range.
TABLE 33 Activity of Individual active Components
Figure BDA0003653790080000381
TABLE 34 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000382
Figure BDA0003653790080000391
Example 17 sunflower downy mildew control test
A potted sunflower seedling with the variety of 'three-eyebrow' in the six-leaf stage (1-4 leaves are cut off and only 5-6 leaves are reserved before the test) is sprayed with aqueous solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, a suspension of sporangium of the downy mildew pathogen of sunflower is inoculated on the leaf, the leaf is cultured in a climatic chamber, after the infection of the disease is completed, the leaf is moved into a greenhouse for culture, and after 12 days, the disease investigation is carried out after the contrast is fully developed.
The data of the activity of each individual active ingredient of the invention for controlling sunflower downy mildew are shown in table 35.
The activity data and synergistic effect of the composition of the invention for controlling sunflower downy mildew are shown in table 36.
The results in Table 36 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on sunflower downy mildew in a test proportioning range.
TABLE 35 Activity of Individual active Components
Figure BDA0003653790080000392
TABLE 36 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000401
Example 18 control of tomato late blight test 1
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf stage tomato seedlings of 'Pingtai ', inoculating tomato late blight pathogen sporangium suspension on tomato leaves after 24 hours, placing the tomato seedlings in a climatic chamber for culture, transferring the tomato seedlings into a greenhouse for culture after infection of diseases is completed, and carrying out disease investigation after 7 days and full control disease.
The activity data of each single active component for preventing and treating the tomato late blight of the invention are shown in a table 37.
The activity data and the synergistic effect of the composition for preventing and treating the tomato late blight are shown in a table 38.
The results in table 38 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on late blight of tomato over the range of the tested ratios.
TABLE 37 Activity of Individual active Components
Figure BDA0003653790080000402
Figure BDA0003653790080000411
TABLE 38 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000412
Figure BDA0003653790080000421
Example 19 test for controlling tomato late blight 2
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf stage tomato seedlings of 'Pingtai ', inoculating tomato late blight pathogen sporangium suspension on tomato leaves after 24 hours, placing the tomato seedlings in a climatic chamber for culture, transferring the tomato seedlings into a greenhouse for culture after infection of diseases is completed, and carrying out disease investigation after 7 days and full control disease.
The activity data of each single active component for preventing and treating the tomato late blight of the invention are shown in a table 39.
The activity data and the synergistic effect of the composition for preventing and treating the tomato late blight are shown in a table 40.
The results in table 40 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) for the composition is greater than 1, indicating that the composition exhibits a synergistic effect on late blight of tomato over the range of the tested ratios.
TABLE 39 Activity of the Individual active Components
Figure BDA0003653790080000422
TABLE 40 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000423
Figure BDA0003653790080000431
Example 20 test for controlling cucumber anthracnose 1
Spraying the cucumber seedlings of two-leaf period potted plant with Xintai Mici with water solution of each active component or composition, naturally drying after spraying, inoculating the cucumber anthracnose pathogen spore water suspension on the cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, carrying out disease investigation after 7 days, grading the leaves according to the development degree of the pathogen infection on the leaves, recording the total leaf number, the diseased leaf number and the disease grade number of the investigation, and calculating the efficacy of the medicament according to a formula.
The activity data of the individual active components of the invention for controlling cucumber anthracnose are shown in table 41.
The activity data and synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 42.
The results in table 42 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose in the range of the tested ratios.
TABLE 41 Activity of Individual active Components
Figure BDA0003653790080000432
Figure BDA0003653790080000441
TABLE 42 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000442
EXAMPLE 21 test for controlling cucumber anthracnose 2
Spraying the cucumber seedlings of two-leaf period potted plant with Xintai Mici with water solution of each active component or composition, naturally drying after spraying, inoculating the cucumber anthracnose pathogen spore water suspension on the cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, carrying out disease investigation after 7 days, grading the leaves according to the development degree of the pathogen infection on the leaves, recording the total leaf number, the diseased leaf number and the disease grade number of the investigation, and calculating the efficacy of the medicament according to a formula.
The activity data of each single active component for preventing and treating cucumber anthracnose are shown in a table 43.
The activity data and synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 44.
The results in table 44 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose in the range of the tested ratios.
TABLE 43 Activity of Individual active Components
Figure BDA0003653790080000443
Figure BDA0003653790080000451
TABLE 44 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000452
EXAMPLE 22 test for controlling Colletotrichum Pepper
Spraying potted six-leaf stage pepper seedlings of 'green round pepper' with aqueous solutions (effective component concentrations are shown in the following table) of active components or compositions, inoculating pepper anthracnose pathogen spore suspension on the back of leaves after 24 hours, culturing in a climate chamber, transplanting into a greenhouse for culturing after infection of diseases is completed, and performing disease investigation after full control disease occurs after 5-7 days.
The activity data of each single active component for preventing and treating the pepper anthracnose are shown in a table 45.
The activity data and synergistic effect of the composition for preventing and treating pepper anthracnose are shown in Table 46.
The results in Table 46 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on pepper anthracnose in a test proportioning range.
TABLE 45 Activity of Individual active Components
Figure BDA0003653790080000453
Figure BDA0003653790080000461
TABLE 46 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000462
Figure BDA0003653790080000471
Example 23 test for controlling eggplant cercospora brown spot
Spraying the eggplant seedlings in five-leaf period potted in Liaoqie No. 1 with aqueous solution (concentration is shown in the table below) of each active component or composition, inoculating the eggplant phomopsis alternata spore suspension on eggplant leaves after 24 hours, culturing in a climatic chamber, transplanting into a greenhouse for culturing after the diseases are infected, and performing disease investigation after 10 days and fully developing diseases in contrast.
The activity data of the individual active components of the invention for controlling eggplant cercospora brown spot are shown in table 47.
The activity data and the synergistic effect of the composition for preventing and treating the eggplant cercospora brown spot are shown in a table 48.
The results in Table 48 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on eggplant cercospora brown spot in a test proportioning range.
TABLE 47 Activity of Individual active Components
Figure BDA0003653790080000472
TABLE 48 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000473
Figure BDA0003653790080000481
Example 24 test for controlling leaf spot disease of eggplant
The method comprises the steps of carrying out spray treatment on potted five-leaf eggplant seedlings of 'Liaoqie No. 1' with aqueous solutions (the concentration is shown in the table below) of active components or compositions, inoculating eggplant corynespora cassiacola spore suspension on eggplant leaves after 24 hours, culturing in a climatic chamber, transferring the eggplant leaves into a greenhouse for culture after infection of diseases is completed, and carrying out disease investigation after 8 days and full disease attack of contrast.
The activity data of the individual active ingredients of the invention for controlling eggplant solanum melongena leaf spot are shown in table 49.
The activity data and the synergistic effect of the composition for preventing and treating the leaf spot disease of eggplant, namely the corynespora solani, are shown in a table 50.
The results in Table 50 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of (A to B)>1, the composition shows a synergistic effect on the leaf spot of eggplant, namely the corynespora solanacearum in a test proportioning range.
TABLE 49 Activity of Individual active Components
Figure BDA0003653790080000482
Figure BDA0003653790080000491
TABLE 50 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000492
Figure BDA0003653790080000501
EXAMPLE 25 Pear Blackspot control test
Taking the tender leaves of potted seedlings of 'bergamot pears', disinfecting the surfaces, washing the leaves clean with sterile water and drying in the shade for later use. Soaking with water solution (concentration shown in the table below) of each active component or composition, inoculating leaf blade with Pyricularia nivalis spore suspension after 24 hr, placing in culture dish (containing 2% water agar) and culturing under constant temperature illumination, and after 14 days, performing disease investigation after control fully attacks disease.
The data of the activity of each individual active ingredient of the invention for controlling pear black spot are shown in table 51.
The activity data and synergistic effect of the composition for preventing and treating pear black spot are shown in table 52.
The results in Table 52 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of (A to B)>1, the composition shows a synergistic effect on pear black spot in a test proportioning range.
TABLE 51 Activity of Individual active Components
Figure BDA0003653790080000502
Figure BDA0003653790080000511
TABLE 52 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000512
Example 26 peanut leaf spot control test 1
Two pairs of potted plant double-leaf flat-growth peanut seedlings of 'Baisha' are sprayed with aqueous solutions (the concentration is shown in the table below) of active components or compositions, after 24 hours, peanut brown germ spore suspension is inoculated on leaves and cultured in a climatic chamber, after the diseases are infected, the leaves are moved into a greenhouse for culture, and after 10 to 12 days, disease investigation is carried out after full control is developed.
The data of the activity of each individual active ingredient of the invention for controlling the leaf spot of peanut are shown in table 53.
The activity data and synergistic effect of the composition for preventing and treating peanut leaf spot are shown in table 54.
The results in Table 54 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on the peanut leaf spot within the range of the experimental mixture ratio.
TABLE 53 Activity of Individual active Components
Figure BDA0003653790080000521
TABLE 54 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000522
Example 27 peanut leaf Spot control test 2
Two pairs of potted plant double-leaf flat-growth-period peanut seedlings of 'Baisha' are treated by spraying with aqueous solutions (the concentrations are shown in the table) of active components or compositions, after 24 hours, peanut brown germ spore suspension is inoculated on leaves and cultured in a climate chamber, after the infection of diseases is completed, the leaves are moved into a greenhouse for culture, and after 10-12 days, disease condition investigation is carried out after full control and disease attack.
The data of the activity of each individual active ingredient for controlling the peanut leaf spot disease are shown in table 55.
The activity data and synergistic effect of the composition for preventing and treating peanut leaf spot are shown in table 56.
The results in Table 56 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of (A to B)>1, the composition shows a synergistic effect on the peanut leaf spot in the range of the experimental mixture ratio.
TABLE 55 Activity of Individual active Components
Figure BDA0003653790080000531
TABLE 56 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0003653790080000532
EXAMPLE 28 wheat scab control test
The potted two-leaf period wheat seedling of the variety Liaochun 18 is treated by spraying with aqueous solution (concentration is shown in the table) of each active component or composition, 24 hours later, the suspension of the wheat scab germ spores is inoculated on the leaves and cultured in a greenhouse, and after 5 days, the disease condition is investigated after the control fully attacks the disease.
The activity data of each single active component for preventing and treating wheat scab is shown in a table 57.
The activity data and synergistic effect of the composition for preventing and treating wheat scab are shown in Table 58.
The results of Table 58 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on wheat scab in a test proportioning range.
TABLE 57 Activity of Individual active Components
Figure BDA0003653790080000541
TABLE 58 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000542
Example 29 test for controlling Rice sheath blight disease 1
Potted two-leaf stage rice seedlings of the variety "Longdao 18" were treated with spray with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, 24 hours later, suspension of rice sheath blight hypha was inoculated on rice leaves and cultured in a greenhouse, and after 5 days, disease investigation was conducted after full control.
The activity data of each individual active component of the invention for preventing and treating rice sheath blight disease are shown in table 59.
The activity data and synergistic effect of the composition for preventing and treating rice sheath blight disease are shown in Table 60.
The results of Table 60 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on rice sheath blight in a test mixture ratio range.
TABLE 59 Activity of Individual active Components
Figure BDA0003653790080000551
TABLE 60 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000552
Figure BDA0003653790080000561
Example 30 test for controlling rice sheath blight 2 potted two-leaf stage rice seedlings of "Longdao 18" were treated with spray with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, 24 hours later, the suspension of hyphae of Rhizoctonia solani was inoculated on the rice leaves and cultured in a greenhouse, and after 5 days, disease investigation was conducted after the control had sufficiently developed.
The data of the activity of each individual active ingredient for controlling rice sheath blight disease of the present invention are shown in table 61.
The activity data and synergistic effect of the composition for preventing and treating rice sheath blight disease are shown in Table 62.
The results in Table 62 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on rice sheath blight in a test mixture ratio range.
TABLE 61 Activity of Individual active Components
Figure BDA0003653790080000571
TABLE 62 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000572
Figure BDA0003653790080000581
Example 31 test for controlling bacterial blight of rice
Planting rice (variety is overtight) in the same pot of a greenhouse, 8 plants/pot, spraying water solution of each active component or composition when the rice grows to the four-leaf stage, uniformly spraying the activated rice bacterial leaf blight strain on rice leaves after 24 hours, preserving moisture for 24 hours by artificial gas, and then transferring the rice leaves into the greenhouse for continuous culture. After the control of clear water is sufficiently diseased, the length of the disease spots of each treated leaf is measured, and the disease inhibition rate, namely the observation effect, is calculated by the following formula.
Figure BDA0003653790080000582
The activity data of each individual active component for preventing and treating the bacterial blight of rice are shown in a table 63.
The activity data and synergistic effect of the composition for preventing and treating bacterial blight of rice are shown in Table 64.
The results in Table 64 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on rice bacterial leaf blight within a test mixture ratio range.
TABLE 63 Activity of Individual active Components
Figure BDA0003653790080000583
TABLE 64 Activity and synergy of the compositions of the invention
Figure BDA0003653790080000584
Figure BDA0003653790080000591
Example 32 treatment of pepper anthracnose
Inoculating pepper seedling with green round pepper variety in six-leaf period to pepper colletotrichum spore suspension, culturing in climate chamber for 24 hr, spraying with water solution of active components or compositions (effective component concentration shown in the following table), culturing in greenhouse, and investigating disease condition after full control disease occurrence after 5-7 days.
The data on the therapeutic activity of the individual active ingredients and compositions of the invention against anthracnose of capsicum are shown in tables 65 and 66.
The results in tables 65 and 66 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on pepper anthracnose in a test proportioning range.
TABLE 65 therapeutic efficacy of active ingredients and synergistic effect of the compositions
Figure BDA0003653790080000592
Figure BDA0003653790080000601
TABLE 66 therapeutic efficacy of active ingredients and synergistic effect of the compositions
Figure BDA0003653790080000602
EXAMPLE 33 persistent test for controlling powdery mildew of Capsicum
The pepper seedlings in the six-leaf period of potted plants of the variety 'green round pepper' are treated by spraying with aqueous solutions (the concentration of active ingredients is shown in the table below) of the active components or the compositions, the pepper powdery mildew spores are sprayed on the back surfaces of the leaves by an inoculator after 1 day, 3 days, 5 days, 7 days and 10 days, the pepper powdery mildew spores are cultured in a greenhouse, and disease investigation is carried out after the control fully attacks 20-25 days.
The data on the activity of the individual active ingredients and the compositions according to the invention for controlling powdery mildew of capsicum are shown in table 67.
The results in Table 67 below show that the observed efficacy of the individual components and compositions of the invention on powdery mildew of capsicum also decreased gradually with increasing inoculation time after dosing; at the same concentration, when inoculated 5 days after the drug administration, the observed efficacy of the individual components is 50 percent lower, and the observed efficacy of the composition is higher than 60 percent; after inoculation for 10 days after the application, the observation effect of the single component is not obvious, the observation effect of the composition is about 30 percent, and the obvious control effect is shown. The single components of the invention are used in the form of a composition, which enhances the lasting activity of the medicament on the powdery mildew of hot pepper.
TABLE 67 persistent activity and synergism of active ingredients
Figure BDA0003653790080000603
Figure BDA0003653790080000611
Example 34 field test for controlling cucumber powdery mildew
In the middle stage of powdery mildew development of cucumber (variety "fruit cucumber") in a sunlight greenhouse, spray treatment was performed with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, and after 15 days, disease investigation was performed.
The activity data of the individual active ingredients of the invention for controlling cucumber powdery mildew are shown in table 68.
The activity data and synergistic effect of the composition for preventing and treating cucumber powdery mildew are shown in Table 69.
The results of Table 69 below show the observed efficacy of the compositions (C) obs ) And expected efficacy (C) exp ) All ratio of>1, the composition shows a synergistic effect on cucumber powdery mildew in the field in the range of the experimental mixture ratio.
TABLE 68 Activity of Individual active Components
Figure BDA0003653790080000612
TABLE 69 Activity and synergy of the compositions of the present invention
Figure BDA0003653790080000613

Claims (10)

1. A germicidal composition, characterized by: the composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99: 1;
wherein, the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof; the active component B is selected from a bactericide.
2. The germicidal composition of claim 1, wherein: the pyrimidine-containing substituted pyrazole compound is a compound shown as a general formula I-A or I-B or a salt thereof:
Figure FDA0003653790070000011
in the formula:
R 1 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical、C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio, halogeno C 1 -C 4 Alkylthio radical, C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl radical, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkynyl, C 3 -C 4 Alkenyloxy, halogeno C 3 -C 4 Alkenyloxy radical, C 3 -C 4 Alkynyloxy, halo C 3 -C 4 Alkynyloxy, C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylaminocarbonyl, halogeno C 1 -C 4 Alkylaminocarbonyl radical, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl or C 1 -C 4 Alkylthio group C 1 -C 4 An alkyl group;
R 2 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group;
R 3 selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkynyl, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylsulfinyl, halogeno C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl radical, C 1 -C 4 Alkylaminosulfonyl, di (C) 1 -C 4 Alkyl) aminosulfonyl, C 1 -C 4 Alkylsulfonylaminocarbonyl group, C 1 -C 4 Alkylcarbonylaminosulfonyl radical, C 3 -C 4 Cycloalkyloxycarbonyl radical, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl group, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkyl carbonyl radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylaminocarbonyl, di (C) 1 -C 4 Alkyl) aminocarbonyl, C 2 -C 4 Alkenyloxycarbonyl radical, C 2 -C 4 Alkynyloxycarbonyl, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylaminosulfenyl, di (C) 1 -C 4 Alkyl) aminosulfanyl, arylcarbonyl C 1 -C 4 Alkyl, arylcarbonyl, aryloxycarbonyl, aryl C 1 -C 4 Alkyloxycarbonyl, aryl C 1 -C 4 Alkyl, heteroaryl carbonyl C 1 -C 4 Alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroaryl C 1 -C 4 Alkyloxycarbonyl or heteroaryl C 1 -C 4 An alkyl group;
R 4 、R 5 can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 4 、R 5 C attached thereto may also form C 3 -C 4 A ring of (a);
R 6 、R 7 can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 6 、R 7 C attached thereto may also form C 3 -C 4 A ring of (a);
R 8 、R 9 can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl, unsubstituted or substituted by 1 to 5R 11 Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;
R 11 selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, C 2 -C 4 Alkenyloxy, halogeno C 2 -C 4 Alkenyloxy radical, C 2 -C 4 Alkynyloxy, halo C 2 -C 4 Alkynyloxy, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl radical, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl group, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxy radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl, halo C 1 -C 4 Alkoxycarbonyl radical C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylthio carbonyl group C 1 -C 4 Alkyl, halo C 1 -C 4 Alkylthio carbonyl group C 1 -C 4 Alkyl radical, C 1 -C 4 Alkylcarbonyloxy, halo C 1 -C 4 Alkylcarbonyloxy, C 1 -C 4 Alkoxycarbonyloxy, halo C 1 -C 4 Alkoxycarbonyloxy, C 1 -C 4 Alkylsulfonyloxy, halo C 1 -C 4 Alkylsulfonyloxy, C 1 -C 4 Alkoxy radical C 1 -C 4 Alkoxy or halo C 1 -C 4 Alkoxy radical C 1 -C 4 An alkoxy group; n is an integer from 0 to 5, and when n is greater than 1, R 11 May be the same or different;
R 14 、R 15 、R 16 or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy or C 3 -C 4 A cycloalkyl group;
w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio or C 1 -C 4 An alkylsulfonyl group;
the salt of the pyrimidine-containing substituted pyrazole compound is formed by a compound shown in a general formula I-A or I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
the active component B is selected from one or more of a respiration inhibitor bactericide, a nucleic acid metabolism inhibitor bactericide, a cell wall synthesis inhibitor bactericide, a signal transduction inhibitor bactericide, a cytoskeleton and motor protein inhibitor bactericide, a sterol biosynthesis inhibitor bactericide, a phospholipid synthesis inhibitor bactericide, a methionine biosynthesis inhibitor bactericide, a multi-site inhibitor bactericide and an action mechanism unknown bactericide.
3. The germicidal composition as claimed in claim 1 or 2, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula: r is 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r 14 、R 15 、R 16 Or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl or C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-A is formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
active component B is selected from flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramide) B43, zoxamide (zoxamide) B44, metalaxyl (metalaxyl) B45, metalaxyl-M B46, ipropamid (iprovalicarb) B47, cymoxanil (cymoxanil) B48, benalaxyl (benalaxyl-M) B49, flusulfamide (flusulfamide) B50, tiadinil (tiadinil) B51, ethaboxam (etham) B52, cyflufenamid (cyflufenamid) B53, cyhexamid (fenhexamide) B53, fenhexamide (fenfluramine) B53, fenfluramine (fenfluramine) B53, diclofenoxapril B53, metoclopramide (ethimide B53), pyrimethanamide (ethiprole) B53, metoclopramide (ethimide B53, metoclopramide (ethiprol) B53, metoclopramide B, Ethiprole (chlorezoline) B70, dimethachlon (dimethachlon) B71, vinclozolin (vinclozolin) B72, diethofencarb (diethofencarb) B73, metrafenone (metrafenone) B74, pyriofenone B75, carbendazim (carbendazim) B76, thiophanate-methyl (thiophanate-methyl) B77, phenamacril (phenracil) B78, benomyl (benomyl) B79, fuberidazole (fuberidazole) B79, thiabendazole (thiabendazole) B79, thiophanate (thionate) B79, pencyron (pencyron) B79, ethazine (acetofenpyrazamide) B79, fenpyrazamide B79, pyribenzofenapyr (fenpyrazamide) B79, pyribenzofenapyr (fenpyrazone) B79, pyrifenoxapridine (fenpyrazamide B79), pyrifenoxadifenozide B79, pyriproxyfen (fenpyrazamide B79), pyriproxyfen (fenpyrazone B79), pyriproxyfen B79, pyriproxyfen (fenpyrazone B79), pyrifenoxadifenox (fenpyrazone B79, pyrifenoxafen) B79, pyriproxyfen (fenpyrazone B79, pyrifenoxafen B79, pyriproxyfen B79, pyrifenoxadifenofen B36fenapyr (fenpyrazone B79, pyrifenoxadifenofen B79, pyrifenoxafen B79, pyriproxyfen (fenpyrazone B79, pyrifenoxadifenofen B36fenapyr (fenpyrazone B79, pyrifenoxafen B79, pyribenzofenapyr (fenpyrazone B79, pyrifenoxafen B36fenoxafen B79, pyrifenoxadifenofen B79, pyribenzofenapyr (fenpyrazone B79, pyribenzofenapyr (fenpropiconazole B79, pyribenzofenapyr (fenpropiconazole B79, pyribenzofenapyr B36fenapyr B79, pyribenzofenapyr B79, pyribenzofena, Dodecamorph (dodemorph) B100, bromuconazole (bromuconazole) B101, imazalil (triaphenonol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumizole) B105, ipfenthifluzole B106, tetrachloronitrobenzene (cinnarizine) B107, chloroneb (chloroneb) B108, niclofenamide (dicloran) B109, biphenyl (biphenyl) B110, edifenphos (edifenphos) B111, terrazole (triconazole) B112, iodopropynyl butylcarbamate (iodocarb) B113, ipropylbenzenes B114, isoprothiolane (isoprothiolane) B115, fluorothiazole (pyriproxyfen) B125, pyriproxyfen B125, pyrithiobac (isoprothiobac) B126, pyrithiobac (isoprothiobac) B123, pyrithiobac (isoprothiobac-methyl pyrifos) B126, pyrithiobac (isoprothiobac) B123, pyriproxyfen B126, pyrifenozide B126, pyriproxyfen B126, pyrifenofos (pyriproxyfen B126, pyrifenofos (pyrifenofos) B126, pyrifenofos (pyrifenofos-p B, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifenofos-p B, pyrifenofos B126, pyrifenofos B, pyrifenofos-p (pyrifenofos-p B, pyrifenofos B126, pyrifenofos-p B, pyrifenofos (pyrifenofos-p B, pyrifenofos-p (pyrifenofos-p B (pyrifenofos-p B, pyrifenofos-p B (pyrifenofos-p B) B (pyrifenofos-p B) B (pyrifenofos B) B (pyrifenofos B126, pyrifenofos B (pyrifenofos-p B (pyrifenofos B) B126, pyrifenofos B) B, pyrifenofos B120, pyrifenofos B126, pyrifenofos B, pyrifenofos-p B, pyrifenofos B (pyrifenofos B126, pyrifenofos B (pyrifenofos-p B (pyrifenofos B126, pyrifenofos-p B126, pyrifenofos B (pyrifenofos-p B, pyrifenofos B (pyrifenofos B, pyrifenofos B120, pyrifenofos B (pyrifenofos B, pyrifenofos B (pyrifeno, Kasugamycin (kasugamycin) B129, mepanipyrim (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptamycin) B132, oxytetracycline (oxytetracycline) B133, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, sodium metbam (nabam) B140, thiothium (emet) B141, metiram (milneb) B142, mancopper (mancopper) B143, furamebic (cunafeneb) B144, sullur (phram) B145, pteridamycin (ptazim) B149, metiram B147, benthiazolium (benthiazolium) B152, benthiazolium (benthiavalicarb) B152, sulfadimidine (sulfadiazine) B151, sulfadiazine B152, sulfadimidine (sulfadiazine B) B152, sulfadiazine B152, sulfadiazinorine (152), sulfadiazine B152, sulfadiazine B150, sulfadiazine B152, fluanib (sulfadiazine B150, fluanib) B150, fluanib (thiamine B152, fluanib) B150, fluanib (thiamine B150, fluanib) B150, fluanib (thiamine B152, fluanib) B150, fluanib (thiamine B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib) B150, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B152, fluanib (sulfamethoxide B152, fluanib (sulfamethoxide B150, fluanib (sulfamethoxide B150, fluanib) B, fluanib (fluanib, fluanib (fluanib) B150, fluanib (fluanib ) B, fluanib, one or more of oxine-copper (oxide-copper) B160, thiodiazole-copper (thiodiazole-copper) B161, nonylomycin (cuppric nonyl phenyl sulfonate) B162, picarbutrazox B163, aminopyrazine B164, metyltetraproprole B165, dodine (dodine) B166, pyridachlomethyl B167, pyridinone (diomerzine) B168, validamycin (validamycin) B169, pyrisoxazone (ferimzone) B170, tebufloquin B171, imidazoxazine (triazoxide) B172, quinofumelin B173, iflumefenoquin B174, dipyritron B175, and teclofluhalam B176.
4. The germicidal composition as claimed in claim 3, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein the active component A is one or more compounds shown in a general formula I-A or salts thereof;
in the formula, R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical、C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 An alkynyl group; r is 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r is 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino or halogeno C 1 -C 4 An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r 14 、R 15 、R 16 Or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-A is formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramide) B43, zoxamide (zoxamide) B44, metalaxyl-M (metalaxyl-M) B46, ipropamid (iprovalicarb) B47, cymoxanil (cymoxanil) B48, benalaxyl (benalaxyl-M) B49, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, bupirimate (bupirimate) B56, dimethirimol (dimethirimol) B57, ethirimol (ethirimol) B58, hymexazol (hymexazol) B58, octopiroctone B, quinacridone (fenpropiconazole) B58, fenpropiconazole (58), pyrimethanamide (ethiofenoxamide B58), pyrimethanpyrimethanil B (58), pyrimethanidone (36diocarb B58), pyrimethanil B58, pyrimethanil B58, pyrimethanil B58, pyrimethanil B, pyrimethanil, Benomyl (benomyl) B79, pyribenzoxim (ethazone) B85, fenamidol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpyrazamine (fenpyrazamine) B90, fluroxypyr (mefenthifluzole) B91, nuarimol (nuarimol) B92, oxpoconazole (oxypyrazole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyriminostrobin (pyriminozole) B97, simeconazole (simeconazole) B104, ipfenpyrazamide B106, pyrifenofos (pyrifenofos) B125, pyrifenofos (pyrifenofos) B126, pyrifenofos (pyrifenofos) B128, pyrifenofos (pyrifenofos) B119, pyrifenofos (pyrifenofos) B124, pyrifenofos (pyrifenofos) B128, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifos) B119, pyrifenofos (pyrifenofos) B125), pyrifenofos (pyrifenofos) B (pyrifenofos) B, pyrifenofos B128, pyrifenofos (pyrifenofos) B, pyrifenofos (pyrifenofos) B125, pyrifenofos B, pyrifenofos (pyrifenofos B) B125, pyrifenofos B (pyrifenofos B125, pyrifenofos B119, pyrifenofos B125), pyrifenofos B128, pyrifenofos B125, pyrifenofos B104, pyrifenofos B) B, pyrifenofos B (pyrifenofos B125, pyrifenofos B (pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B (pyrifenofos B) B123, pyrifenofos B125, pyrifenofos B) B, pyrifenofos B (pyrifenofos B) B (pyrifenofos B125, pyrifenofos B119, pyrifenofos B123, pyrifenofos B125, pyrifenofos B (pyrifenofos B123, pyrifenofos B) B, pyrifenofos B125, pyrifenofos B123, pyrifenofos B (pyrifenofos B, pyrifenofos B125, pyrifenofos B (pyrifenofos B, pyrifenofos B (pyrifenofos B125, pyrifenofos B (pyrifenofos B, pyrifenofos B119, pyrifenofos B (pyrifenofos B, pyrifenofos B125, pyrifenofos B (pyrifenofos B119, pyrifenofos B (pyri, Kasugamycin (kasugamycin) B129, mepanipyrim (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, metiram (milneb) B142, mancopper (mancoppper) B143, sulfur (sulpholur) B145, dichlofluanid (anilazine) B146, captan (captan) B147, chlorothalonil (chlorothalonil) B149, benflumethamine (dichlorfluanid) B150, tolylfluanid (carbozide) B167, thionochloride B161, thionocathimide B161, thionocathione (thionocathiazole) B163, thionocathiazole B163, thionocathione (thionocathione) B165, thionocathione B163, thionocathion B154, thionocathione B171, thionocathion B163, thionocathione B154, thionocathion B171, thionine B154, thionocathion B170, thionocathione B170, thionocathion B170, thionine B170, thionocathion B170, thionocathione B170, thionocathion B, thionocathione B, thionine B170, thionine B, thionocathione B, thionine B and thionine B170, thionine B and thionine B (thionine B, thionine B (thionine B, thionine, One or more of ipflufenoquin B174, dipyrometron B175 and teclofthalam B176.
5. The germicidal composition as claimed in claim 4, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula, R 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; r 14 、R 15 、R 16 Or R 17 Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro or C 1 -C 4 An alkyl group; w is selected from hydrogen, halogenElement or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramid) B43, zoxamide (zoxamide) B44, metalaxyl-M (metalaxyl-M) B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, bupirimate (bupirimate) B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinidone (chinomethiazide) B60, fludioxonil (fenpyr) B60, fenpropiconazole (fenpyrazoxamide) B60, pyrimethanil (fenpropiconazole) B60, pyrimethanil B60, fenacetophenone (60), fenapyr B60, fenapyr B36fenoxapyroxim B60, fenapyr B36fenoxapyr B60, fenapyr B36fenoxapyr B60, fenapyr B36fenoxapyroxapyr B60, fenapyr B36fenoxapyr B60, fenapyr B36fenoxapyr B60, fenapyr B60, flufenoxapyr B36fenoxapyr B60, flufenoxapyr B60, flupyr B36fenoxapyr B60, flufenoxapyr B60, flupyr B60, flufenoxapyr B60, Simeconazole B104, iprifluorafluozole B106, iprobenfos B114, isoprothiolane B115, oxathidiazuron B116, fluxaprop B117, propamocarb B118, quintozene B121, tolclofos B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinamide B125, pyrimorph (pyrimorph) B126, pyrimorph B125, pyrimorph (pyrimorph) B126, cyprodinil B128, kasugamycin B129, pyrimethanil B149, pyrimethanil B156, pyrimethanil B150, pyrimethanil B155, pyrimethanil B145, pyrimethanil B134, pyrimethanil B150, pyrimethanil B134, pyrimethanil B137, pyrimethanil B129, pyrimethanil B150, pyrimethanil B134, pyrimethanil B150, pyrimethanil B (pyrimethanil B) B150, pyrimethanil B (pyrimethanil B) B, pyrimethanil B150, pyrimethanil B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (pyrimethanil B) B (pyrimethanil B) B, pyrimethanil B (pyrimethanil B) B (bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbensul B) B (bensulbensul B (bensul B) B (bensul B) B (bensulbensulbensul B) B (bensul B (bensulbensulbensulbensul B) B (bensulbensulbensul B) B (bensulbensul B) B (bensulbensulbensul B (bensulbensul B (bensul B) B (bensulbensul B) B (bensul B) B (bensul B (bensulbensul B (bensul B) B (bensul B (bensulbensul B) B (bensul B) B (bensul, One or more of cuppric nonyl phenyl sulfonate B162, picarbtrazol B163, aminopyrifen B164, metyltetrapole B165, pyridachlomethyl B167, validamycin (validamycin) B169, tebufloquin B171, quinofumelin B173, iflumenoquin B174, dipyrometrone B175, and teclofthalam B176.
6. The germicidal composition as claimed in claim 1 or 2, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio radical, C 1 -C 4 Alkylsulfinyl radical, C 1 -C 4 Alkylsulfonyl radical, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl or halo C 2 -C 4 An alkynyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halogeno C 1 -C 4 An alkoxycarbonyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino, halogeno C 1 -C 4 Alkylamino radical, di (C) 1 -C 4 Alkyl) amino, halo-di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-B is formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from benzovindiflupyr (benzovindiflurylpyr) B1, fluxapyroxafen (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyram) B5, flutolanil (flubeneteram) B6, flutolanil (sedaxane) B7, penthiopyrad (penthiopyrad) B8, boscalid (boscalid) B9, bispyribac (bixafen) B10, flutolanil (flutolanil) B11, furametpyr (furametpyr) B12, thifluzamide (thifluzamide) B13, flufenamidofluzamide (diflufenpyrafluzamide B13, furametprofluoride B13, furametprofluorfen B13, furamex B13, flufenamidone B13, furamex B13, flufenamidoxime B13, flufenamidone B13, flufenamide B13, flufenamidothiopyrazamide (13B 13, flufenamidofen) B13, flufenamide B13, flufenamidofen B13, flufenamidone B13, flufenamide B13, flufenamidofen B13, flufenamide B13, flufenamidofen B13, flufenamide B13, flufenamidofen B13, flufenamide B13B, Cyazofamid (cyazofamid) B30, ametoctradin (ametoctradin) B31, fluazinam (fluazinam) B32, fenpicoamid B33, florylpicoxamid B34, amisulbrom (amisulbactam) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B53, triphenyltin chloride (triphenoxytin chloride) B38, diniconic acid ester (cincipap) B39, dinocap (dinocap) B40, flumorph (flumorph) B41, dimethomorph (dimethomomoh) B42, propynil (propadipamid) B42, zofenoxamide (zofenoxamide) B42, fenflurazofamid) B42, cyazofamid (fenazafenoxamide B42, dimethomofenoxamide B42, cyazofamid (fenapyr) B42, dimethomofenoxamide (42), dimethomofenoxamide B42, dimethofenoxamide (42), dimethoxamide B42, dimethofenoxamide (36fenapyr) B42, dimethoxamide B36fenapyr (42), dimethoxamide B42, dimethoxamide B36fenapyr B36fenamide (42), dimethoxamide B36fenamide B42, dimethoxamide B36fenapyr B42, fosfamide B36fenapyr B36fenamide (42, fosfamide B36fenapyr B42, dimethofenapyr B42, fosfamide B36fenapyr B42, fosfamide B36fenapyr B42, fosfamide B36fenapyr B36fenapyr 42, fosfamide B36fenapyr B42, fosfamide B36fenapyr B42, fosfamide B36fenapyr B42, flufenapyr B42, fosfamide B36fenapyr B42, flufenapyr B36fenapyr 42, flufenapyr B36fenapyr B42, flufenapyr 42, Hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, furosemide (ofaurace) B61, quinazone (chinomethionat) B62, oxadixyl (metaxyl) B62, furalaxyl (furalaxyl) B62, fludioxonil (fizoxonil) B62, fenpiclonil (fenticloni) B62, iprodione (iprodione) B62, procymidone (procymidone) B62, metconazole (meclozolid) B62, chlozolinate (chlozolinate) B62, dimethachlon (dimethaclolon) B62, vinclozolin (vinclozolin) B62, ethiofencfencarb (diethylfenpyranpyrafen) B62, pyribenzofenacetone (dimethiazolizone) B62, fenpyrazofenozide) B62, pyribenzofenacetophenone (fenpyrazofenozide) B62, fenpyrazofenoxazone (fenpyrazofenoxazone) B62, fenpyrazofenoxazone B62, fenpyrazofenoxafen (fenpyrazofenoxazone B62, fenpyrazofenoxafen B62, fenpyrazofenoxazone B62, fenpyrazofenoxafen B62, fenpyrazone B62, fenpyrazofenoxafen B62, fenpyroxafen B62, fenpyrazone B62, fenpyroxafen B36fenoxafen B62, fenpyroxafen B36fenoxafen B62, fenpyroxafen B62, fenpropiconazole B36fenoxafen B62, fenpyroxafen B62, fenpyroxafen B36, Chlorofloxacin (mefenthifluzole) B91, nuarimol B92, oxaziridine (oxypolyzole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyrisoxazole (pyrisoxazole) B97, tridemorph (tridemorph) B98, fluazinam (triforine) B99, dodemorph B100, bromuconazole (brofenazol) B101, imazalil (triafol) B102, naftifine (naftifine) B103, simeconazole (simeconazol) B104, flufendazole (triflumzole) B105, pyrithionazole B106, pyrifenozide B120, pyrifenozide (pyrifenozide) B108, pyrifenozide B110, pyrifenozide B108, metoclopramide (propineb) B108, pyrifenozide B110, pyrifenozide B108, pyrifenozide B110, pyrifenozide B110, pyrifenozide B (propidium chloride B, pyrifenozide B (propidium chloride B, pyrifenozide B (propidium chloride B) B (propidium chloride B) B (benazol B) B (propidium chloride B) B110, pyrifenozide B (benazol B (propidium chloride B) B (benazol B) B (benazol B, pyrifenozide B (propidium chloride B (benazol B) B (benazol B) B108, pyrifenozide B110, pyrifenozide B108, pyrifenozide B (benazol B110, pyrifenozide B (propidium chloride B108, pyrifenozide B110, pyrifenozide B108, pyrifenozide B (propidium chloride B108, pyrifenozide B110, pyrifenozide B108, pyrifenozide B (propidium chloride B (propineb B, pyrifenozide B (propineb B110, pyrifenozide B (propineb B108, pyrifenozide B (propineb B110, pyrifenozide B (propineb B, pyrifenozide B (propidium chloride B, pyrifenozide B110, pyrifenozide B (propineb B, pyrifenozide B (propineb, Tolclofos-methyl B122, benthiavalicarb-isopyramid B123, polyoxin B124, valicarb-125, pyrimorph B126, blasticidin B127, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, oxytetracycline B133, zineb B134, mancozeb B135, metiram B136, propineb B149, fenbuconazole B150, fenpropathrin B145, fenfluramine B148, fenfluramine B137, fenflurane B148, fenfluramine B142, fenfluramine B145, fenfluramine B131, streptomycin B137, streptomycin B133, zineb B134, fenfluramine B147, fenfluramine B150, fenfluramine B145, fenfluramine B150, fenfluramine B, flupyr B, fenfluramine B, flupyr B, flufenozide B, flufenofos, flufenoxathim, flufenofos, flufenoxaprop-B, flufenofos, benfluram B, flufenofos, benfluramine B, flufenofos, benfluram B, flufenoxaprop-B, benfluram B, benfluride B, benfluramine B, benfluram B, thim, benfluram B, benfluram, Dithianon B152, fluimide B153, sulfocarb (methasulfocarb) B154, captafol B155, folpet (folpet) B156, iminoctadine B157, guazatine B158, zinc thiazole B159, oxine-copper B160, thiodiazole-copper B161, nonylocin B162, picarbuzox B163, aminopyrifenesin B164, metetraphyloproprile B165, polyformaldehyde B166, pyridalyl B167, pyridazone B168, jinozolomide B168, fluquindoxine B170, fluquinazine B175, fluquinazine B171, fluquinazine B175, fluquinazine B171, fluquinconazole B175, fluquinconazole B170, fluquinconazole B175, fluquinconazole B171, fluquinconazole B175, fluquinconazole B and others.
7. The germicidal composition of claim 6, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylthio radical, C 2 -C 4 Alkenylthio radical, C 2 -C 4 Alkenyl radical, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halogeno C 2 -C 4 An alkynyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 6 、R 7 Can be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxycarbonyl or halo C 1 -C 4 An alkoxycarbonyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkylamino or halogeno C 1 -C 4 An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halo C 1 -C 4 Alkyl radical, C 3 -C 4 Cycloalkyl radical, C 1 -C 4 Alkoxy or C 1 -C 4 An alkylthio group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxad (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrazamide (flupyrazam) B5, flubeneramide (flubeneram) B6, sedaxane (sedaxane) B7, fluthiavalicarb (penthiopyrad) B8, boscalid (boscalid) B9, diphenpyrad (bixafen) B10, flutolanilide (flutolanil) B10, furflupyrazamide (furametpyr) B10, thifluzamide (thifluzamide) B10, flufenpyrazamide (diflufenpyrazamide) B10, flufenpyrafluzamide B10, flufenazamide B10, flufenacetoamide B10, flufenamidoxime B10, flufenamide B10, flufenamidofen B10, flufenamide B10, flufenamidofen B10, flufenamide B10, flufenamidofen B10, flufenamide B, Amisulbrom (amisulbrom) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopramid) B43, zoxamide (zoxamide) B44, mefenoxam (metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cyanamide (momoxamonil) B48, benalaxyl (benaxyl-M) B48, tiadinil (tiadinil) B48, ethaboxam (ethanamizol) B48, ethirimol sulfonate (bupirimate) B48, dimethyphenol (dimethomorph) B72, silthiofam (silthiopham) B48, metoclopramide (ethiofenpyrone) B48, metoclopramide (ethiofenprox) B48, metoclopramide B36ethiofenprox B48, metoclopramide B36difenoconazole B48, metoclopramide B48, metoclopramide B36difenoconazole B, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B48, metoclopramide B, thiophanate-methyl B77, phenamacril B78, benomyl B79, pyribenzoxim B85, fenamidol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpyrazamine (fenpyrazamine) B90, fluroxypyr (mefenthifluzole) B91, nuarimol B92, oxpoconazole B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B3, spiroxamine B96, pyriminostrobin B84, pyriminostrobilurin B77, pyrifenoxathiobac B115, pyrifenoxadinocarb B46122, pyrifenoxathiobac (pyrazofos) B123, pyrifenoxathiobac-methyl B115, pyrifenofos B104, pyrifenofos B737B 123, pyrifenofos B104, pyrifenofos B737B 123, pyrifenofos B104, pyrithiobac (pyrithiobac-methyl pyrithiobac-sodium B108, pyrifos B120, pyrithiobac (pyrifos) B120, pyrifos B104, pyrithiobac (pyrifos B104, pyrifos B113, pyrifos B104, pyrifos B, pyrithiobac (pyrifos B, pyrifos B123, pyrifenofos B, pyrifos B104, pyrifos B, pyrithiobac-pyrathiopyrathiopyrathiobac (pyrifos B123, pyrifos B123, pyrifos B (pyrifos B, pyrifos B (pyrifos B123, pyrifos B123, pyrifos B123, pyrifos B, pyrifos, Valienamine B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, ambam B139, mancozeb B142, manocopper B143, sulpiride B145, trichloram B146, captoprene B147, carboline B156, carboline B162, carboline B154, carboline B150, carboline B154, carboline B150, carboline B, carboline B, one or more of pyridachloromethyl B167, validamycin B169, pyrizonone B170, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175 and teclofthalam B176.
8. The germicidal composition as claimed in claim 7, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C 1 -C 4 An alkyl group; r 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C 1 -C 4 An alkyl group; r 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r 4 、R 5 Can be the same or different and are respectively selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r 6 、R 7 May be the same or different and are each selected from hydrogenHalogen or C 1 -C 4 An alkyl group; r 8 、R 9 Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxafen (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyrazam) B5, fluorophenyletheramide (flubentiam) B6, sedaxane (sedaxane) B7, penthiopyrad (penthiopyrad) B7, boscalid (boscalid) B7, bispyramid (bixafen) B7, thifluzamide (thifluzamide) B7, fluxapyroxamide (pyflutolofen) B7, fluazinam (pydiflufenpyrad) B7, fluazimide (fluquinconazole) B7, flufenamidopropyl flufenamide (flufenamidopropyl flufenamide) B7, flufenamidone (flufenamide B7), flufenamidone (flufenamid B7), flufenamid B7, flufenamidone B7, flufenamid B, Zoxamide (zoxamide) B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, tiadinil B51, ethaboxam (ethaboxam) B52, bupirimate B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinazone (chinomethionat) B62, fludioxonil (fludioxonil) B65, iprodione (iprodione) B67, procymidone (procymidone) B68, diethofenfafenib B2, metrafilone (metryxol) B56, isophthora pirillum (iprodione) B91, isoprothiolane B3676, isoprothiolane (isophthora B) B91, isophthora B3676, isophthora B91, isoprothiolane (isophthora B) B91, isoprothiolane B3676, isophthora B3676, isophthora piriripyrrocarb (isophthora B3676, isophthora pirillon, isophthora B3676, isophthora pirillum (isophthora B36fenoxadifenofos, isophthora B3676, isoprothiolane (isophthora B3676, isophthora B36fenoxadifenofos, isophthora B3676, isoprothiolane (isophthora B3676, isophthora B36fenoxadifenom, isophthora B3676, isoprothiolane (isophthora B3676, isophthora B36fenoxadifenom, isophthora B368, isophthora B3676, isoprothiolane (isophthora B36fenoxadifenom, isophthora B3676, flupyr, isophthora B36fenoxadifenom, isophthora B3676, isophthora B36fenoxadifenom, isophthora B3676, isophthora B3676, isophthora B, isop, Fluothiazole pyriproxyfen B116, fluxapriroline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B149, propiconazole B160, pyrimethanil B161, pyrimethanil B162, pyrimethanil B150, pyrimethanil B162, pyrimethanil B150, pyrimethanil B (bencarb B, pyrimethanil B (bensulbencarb B (ben B, pyrimethanil, One or more of pyridachlorometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175, and teclofthalam B176.
9. Use of a fungicidal composition according to claim 1, characterized in that: the bactericidal composition is used for preparing medicines for preventing and treating plant pathogenic fungi and bacterial diseases.
10. Use of a fungicidal composition according to claim 6, characterized in that: the plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, leaf mold, banded sclerotial blight, damping off, black nevus, smut, powdery mildew, downy mildew, late blight, epidemic disease, downy mildew, black shank, soft rot, damping-off, phytophthora blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, gummy stem blight, gray mold, sclerotinia, rot, root rot, gibberellic disease, soft rot, bacterial blight, leaf blight, angular leaf spot, circular leaf spot, bacterial leaf blight, bacterial wilt, ulcer disease or yellow dragon disease.
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CN111316991A (en) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 Fungicidal compositions and uses
CN111316992A (en) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 Fungicidal composition and application thereof

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