CN111184001B - Composition containing biphenylpyrazinamide and fluazinam and application thereof - Google Patents
Composition containing biphenylpyrazinamide and fluazinam and application thereof Download PDFInfo
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- CN111184001B CN111184001B CN202010127829.3A CN202010127829A CN111184001B CN 111184001 B CN111184001 B CN 111184001B CN 202010127829 A CN202010127829 A CN 202010127829A CN 111184001 B CN111184001 B CN 111184001B
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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Abstract
The invention relates to a composition containing biphenylpyrazinamide and fluazinam and application thereof. The bactericidal composition can be used for synergistically preventing and treating ginseng sclerotinia rot, Chinese cabbage sclerotinia rot, strawberry gray mold, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia rot, tomato gray mold, tomato sclerotinia rot, eggplant gray mold, pepper gray mold and pepper sclerotinia rot, and has an unexpected synergistic effect.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a composition containing biphenyl pyrazinyl bacteria amine and application thereof.
Background
Pyraziflumumid (test code NNF-0721) (hereinafter referred to as biphenylpyrazinecarboxamide) is known under the chemical name of N- (3',4' -difluorobiphenyl-2-yl) -3- (trifluoromethyl) pyrazine-2-carboxamide, and is produced by japan pesticide co.
Chinese patent application No. 200680046968.1 discloses the structural formula of biphenyl pyrazinamide, and describes the preparation method and the experimental effect of preventing and treating plant diseases.
WO2016060230a1 discloses formulations of biphenylpyrazinecarboxamide, wherein it is mentioned that any fungicide can be used as the second active ingredient in the formulation, but it is not clear which biphenylpyrazinecarboxamide and which fungicide combinations can have a synergistic effect, which have an antagonistic effect, and which produce an additive effect.
The prothioconazole not only has good systemic activity, excellent protection, treatment and eradication activity, but also has long lasting period. Through a large number of field efficacy tests, the results show that the prothioconazole has good safety and good disease prevention and treatment effects on crops, and is mainly used for preventing and treating a plurality of diseases of cereal crops such as wheat, barley, rape, peanut, rice, bean crops and the like.
The boscalid is mainly used for preventing and treating powdery mildew, gray mold, various rot diseases, brown rot, root rot and the like, and is mainly used for preventing and treating diseases of rape, grapes, fruit trees, vegetables, field crops and the like.
The fluazinam is a protective bactericide, can prevent and treat diseases caused by botrytis cinerea, is very effective on alternaria, botrytis, phytophthora, monascus, sclerotinia and black reclamation bacteria, has a good effect on botrytis cinerea of benzimidazoles and dicarboximide bactericides, is rain wash resistant, has a long lasting period, has a good effect of controlling phytophagous mites, also has an excellent prevention effect on cruciferous clubroot and also has a good prevention effect on rice damping-off caused by rhizopus.
However, in the process of controlling crop diseases, the single agent has large dosage or improved resistance after long-term use, and the control effect is reduced.
Disclosure of Invention
In order to solve the technical problems, the invention provides a bactericidal composition, which is characterized by comprising a bactericidal active ingredient A and a bactericidal active ingredient B, wherein the bactericidal active ingredient A is a compound shown as the following formula (I):
the bactericidal active ingredient B is selected from one of prothioconazole, boscalid and fluazinam.
Wherein, the compound of formula (I) is named as biphenyl pyrazinyl bacteria amine in the invention.
Preferably, in the bactericidal composition, the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 1:100 to 100:1, and preferably, the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 1:80 to 80: 1. Particularly preferably, the weight ratio of the biphenylpyrazinamide to the prothioconazole is 1:3, 3:1 or 1:1, the weight ratio of the biphenylpyrazinamide to the boscalid is 1:40, 10:1 or 1:8, and the weight ratio of the biphenylpyrazinamide to the fluazinam is 10:1, 8:1 or 1: 20.
Preferably, in the bactericidal composition, the bactericidal active ingredient B is fluazinam, and the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 80:1, 8:1 or 1: 80.
Preferably, in the above bactericidal composition, the sum of the weight of the bactericidal active ingredient a and the weight of the bactericidal active ingredient B accounts for 1 to 70 percent of the weight of the bactericidal composition, and preferably accounts for 5 to 60 percent of the weight of the bactericidal composition.
Preferably, the bactericidal composition further comprises a third bactericidal component, and the third bactericidal component is one selected from an amide bactericide, a dicarboximide bactericide, a triazole bactericide, an imidazole bactericide, an oxazole bactericide, a morpholine bactericide, a pyrrole bactericide, a pyridine bactericide, a pyrimidine bactericide, a quinazolinone bactericide, a carbamate bactericide, an organic phosphorus bactericide, a thiocarbamate bactericide, a copper preparation, a bactericide, and other bactericides.
Preferably, the amide fungicide is selected from thifluzamide, propionibamide, fenhexamid, fenpropamide, silthiopham, furametpyr, zoxamide, metalaxyl-M, metalaxyl, benalaxyl, diclocyanamide, sulfenamide, tiadinil, isotianil, flutolanil, cyflufenamid, penthiopyrad, diynamide, carboxin, enestrobin, fluoxafen, orysastrobin, trifloxystrobin, fluoxastrobin, flupyraclostrobin, cyazofamid, valcarb, fluoxastrobin, coumoxystrobin, pyraclostrobin, trifloxystrobin, kresoxim-methyl, dimoxystrobin, metominostrobilurin, metominostrobin, triclosan-methyl, clorine, trifloxystrobin;
the dicarboximide bactericide is selected from procymidone, iprodione, vinclozolin, fluocinolone, tolcloride, ethephon, sclerotinia, captafol, captan, folpet, climbazole, sterile phosphorus, and sulfur chlorophenylimine;
the triazole bactericide is selected from epoxiconazole, triadimefon, diniconazole, myclobutanil, tebuconazole, propiconazole, prothioconazole, metconazole, tetraconazole, triticonazole, ipconazole, fenbuconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, penconazole, simeconazole, triadimenol, bitertanol and tricyclazole;
the imidazole bactericide is selected from carbendazim, prochloraz, thiophanate-methyl, probenazole, prothioconazole, fuberidazole, imazalil, benomyl and triflumizole;
the oxazole bactericide is selected from hymexazol;
the morpholine bactericide is selected from dimethomorph, flumorph and tridemorph;
the pyrrole bactericide is selected from dimethachlon, fenpiclonil and fludioxonil;
the pyridine bactericide is selected from the group consisting of pyribenzoxim, cyprodinil, bixafen, fluopicolide, pyrimethanil, buthionine and boscalid;
the pyrimidine bactericide is selected from cyprodinil, fluopyram, mepanipyrim, pyrimethanil, fenarimol, flufenarimol, bupirimate, dimetrimol, ethirimol, pyrizone and pyrimethanl;
the quinazolinone bactericide is selected from dithianon;
the carbamate bactericide is selected from diethofencarb, iprovalicarb, benthiavalicarb, propamocarb, sulbencarb and amikazadol;
the organic phosphorus bactericide is selected from diphacinone, iprobenfos, pyrazophos, tolclofos-methyl, pyrifenoxan, ethylphosphonic acid, phosphorus for seed soaking, and captafos;
the thiocarbamate fungicide is selected from mancozeb, maneb, zineb, propineb, amobam, thiram, ziram, thiram oxide, morbus, ferbam, sodium metiram, thiram, sulphur, metiram and zineb;
the copper preparation is selected from Bordeaux mixture, copper acetate, copper carbonate, copper oxychloride, copper silicate, basic copper sulfate, cuprous oxide, and oxine-copper;
the bactericide is selected from blasticidin, kasugamycin, polyoxin, validamycin, diclazone, bismerthiazol, bronopol, copper hydroxide, ethylicin, sodium disulfate, quinconone, oxytetracycline, bismertin, probenazole, thielavone, thienconch, simetryn and thiazole zinc;
other bactericide is selected from isoprothiolane copper oxychloride, metrafenone, spiroxamine, azinam-clonitron, indomethamide, trichlofop, thiophanate, dichloronaphthoquinone, fenpyrazamine, cyhalothrin, thiophanate, fluazinam, and a,
The third sterilization component accounts for 1-50% of the sterilization composition by weight, preferably, 1-30%.
Preferably, in the above bactericidal composition, the bactericidal composition further comprises a pesticide carrier and a pesticide adjuvant, and the sum of the weight of the pesticide carrier and the weight of the pesticide adjuvant accounts for 1 to 90 percent of the weight of the bactericidal composition, preferably 1 to 80 percent of the weight of the bactericidal composition.
In the above bactericidal composition, the pesticide carrier is a liquid carrier (or a solvent) or a solid carrier, wherein the liquid carrier is selected from one or more of water, aromatic hydrocarbons, aliphatic hydrocarbons, ketones, ethers, and the like, preferably, from one or more of water, acetone, cyclohexanone, xylene, benzene, cyclohexane, isopropanol, ethylene glycol, sorbitol, methanol, ethanol, butanol, dimethylformamide, decalin, machine oil, petroleum ether, cyclohexanone, methyl oleate, methylated soybean oil, and the like, and a part of the liquid carrier may be used as a cosolvent, for example, methanol, phenol, isoamyl alcohol, dimethyl sulfoxide, ethyl acetate, butanone, dimethylformamide, tetradecanol, ethylene glycol, and the like may be used as a cosolvent.
The solid carrier is selected from one or more of natural or synthetic clays and silicates, naturally occurring rock flour, chalk, quartz, clays, montmorillonite, silica, diatomaceous earth, pumice, gypsum, talc, bentonite, kaolin, china clay, synthetic ground minerals, crushed and graded calcite, marble, pumice, sepiolite, dolomite and the like.
The pesticide adjuvant is selected from one or more of emulsifier, dispersant, wetting agent, thickener, defoamer, oxidant, antifreeze, disintegrant and the like.
Preferably, the emulsifier is selected from one or more of ethoxylated castor oil, polyoxyethylene phenethyl phenol ether oleate, alkylaryl polyoxyethylene polyoxypropylene ether, agricultural milk 0201B, agricultural milk 36#, alkylaryl formaldehyde resin polyoxyethylene ether, diphenyl phenol polyoxyethylene ether formaldehyde condensate, agricultural milk 1601#, sodium dodecyl sulfate, agricultural milk 700#, agricultural milk NP-7, agricultural milk 0203B, agricultural milk 2201#, agricultural milk S-80, agricultural milk 507#, agricultural milk NP-15, agricultural milk T-20, agricultural milk 100#, agricultural milk 600#, and the like.
Preferably, the dispersant is selected from one or more of sodium lignosulfonate, calcium lignosulfonate, sodium naphthalene sulfonate formaldehyde condensate, methyl naphthalene sulfonate formaldehyde condensate, sodium methylene naphthalene sulfonate, sodium methyl aminoethyl oleate, epoxy polyether, p-tert-butyl ether, piperonyl butyl ether, alkylamido taurate, dibutyl naphthalene sulfonate formaldehyde condensate, alkylphenol polyoxyethylene phosphate, methyl cellulose, sodium naphthol sulfonate formaldehyde condensate and the like.
Preferably, the wetting agent is selected from one or more of sodium sulfate, sodium lauryl sulfate, sodium methylene naphthalene sulfonate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, sodium alkyl naphthalene sulfonate fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, and the like.
Preferably, the thickener is selected from one or more of carboxymethyl alcohol, polyvinyl acetate, xanthan gum, gelatin gum, gum arabic, polyvinylpyrrolidone, magnesium aluminum silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, soluble starch, carboxymethyl cellulose and sodium alginate.
Preferably, the defoaming agent is selected from one or more of natural products such as natural products, natural products and the like, wherein the natural products are natural products, and the natural products are natural products.
Preferably, the oxidant is selected from one or more of potassium chlorate, sodium chlorate, potassium perchlorate, sodium nitrate, potassium nitrate and potassium permanganate.
Preferably, the antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, urea and sodium chloride.
Preferably, the disintegrating agent is selected from one or more of ammonium sulfate, urea, sucrose, glucose, citric acid, succinic acid and sodium bicarbonate.
The invention also provides a composition preparation prepared from the composition, and the preparation is missible oil, a suspending agent, a water dispersible granule, an aqueous emulsion, a microemulsion, a soluble liquid agent, a wettable powder, a suspension seed coating agent, a granular agent or an oil suspending agent.
The above composition preparation can be prepared by conventional processing method, i.e. mixing active ingredient with liquid carrier or solid carrier, and adding one or more of the above adjuvants such as emulsifier, dispersant, etc. Typically, the germicidal composition includes at least one carrier and at least one surfactant. In each case, a homogeneous distribution of the active ingredient in the above-mentioned compositions should be ensured.
The invention also provides application of the bactericidal composition, and the bactericidal composition is used for preventing and treating plant diseases.
Preferably, the bactericidal composition is used for controlling plant diseases such as ginseng sclerotinia rot, Chinese cabbage sclerotinia rot, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia rot, tomato sclerotinia rot, eggplant gray mold, pepper gray mold or pepper sclerotinia rot, and comprises a bactericidal active ingredient A and a bactericidal active ingredient B, wherein the bactericidal active ingredient A is a compound shown in the following formula (I):
preferably, in the application of the bactericidal composition, the bactericidal active ingredient B is fluazinam, the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 1:80 to 80:1, and the weight ratio of the bactericidal active ingredient A to the fluazinam is 20:1, 8:1 or 1: 20.
The invention also provides a method for preventing and treating plant diseases by applying the bactericidal composition to the stem and leaf parts, the roots or plant seeds of plants in a bactericidal effective amount in a spraying mode, a root application mode or a seed coating mode.
Preferably, the plant diseases are wheat stripe rust, wheat leaf rust, wheat stem rust, wheat scab, wheat yellow dwarf, wheat soil-borne mosaic, wheat stripe mosaic, wheat streak mosaic, big, wheat loose smut, wheat stem smut, wheat black smut, wheat powdery mildew, wheat take-all, wheat sharp eyespot, wheat downy mildew, barley stripe, barley net blotch, wheat snow mildew leaf blight, wheat helminthosporium root rot leaf spot, rice blast, false smut, rice sheath blight, rice bacterial stripe, rice flax spot, bakanae disease, rice rot, rice stalk rot, rice stripe leaf blight, rice red blight, maize big, small spot, maize round spot, maize head smut, maize black smut, maize bacterial wilt, maize mosaic disease, maize dwarf mosaic disease, maize yellow rot, maize, wheat stripe leaf blight, wheat stripe leaf spot, rice stem rot, rice stripe leaf blight, rice leaf blight, maize black smut, maize black spot, maize bacterial wilt, maize bacterial leaf blight, maize yellow spot, maize yellow leaf blight, maize yellow leaf spot, maize, Maize rough dwarf, maize bacterial wilt, maize downy mildew, maize curvularia leaf spot, maize gray leaf spot, maize anthracnose, maize take-all, sorghum head smut, sorghum loose smut, sorghum head smut, sorghum long-grain smut, sorghum anthracnose, penicillium glumae glume blight, sorghum black bunch disease, sorghum top rot, sorghum smut, millet powdery mildew, millet smut, millet red leaf disease, sweet potato black spot, garlic sprout root rot, potato ring rot, potato late blight, potato early blight, potato cancer, soybean drug leaf disease, soybean top blight, soybean sclerotinia, soybean root rot, soybean cyst disease, soybean gray leaf spot, soybean downy mildew, soybean bacterial blight, soybean bacterial leaf spot, soybean violet spot, soybean leaf spot, soybean brown rust, peanut root knot nematode disease, soybean leaf spot, corn anthracnose, corn head rot, corn head blight, corn stalk knot nematode disease, corn head rot, corn head blight, corn head rot, corn head blight, Peanut stem rot, peanut black spot, peanut brown spot, peanut net blotch, peanut rust, peanut virus disease, cotton wilt, cotton verticillium wilt, cotton seedling disease, cotton angular leaf spot, cotton boll disease, flax rust, flax wilt, tobacco black shank, tobacco anthracnose, tobacco brown spot, beet powdery mildew, beet root rot, beet clump root disease, pear scab, pear rust, pear ring rot, pear black spot, pear brown rot, pear blight, apple rot, apple rust, apple defoliation, apple rust, apple virosis, apple leaf rot, apple root rot, apple purple rot, apple leaf scald, apple anthracnose, apple ring rot, apple penicilliosis, apple heart rot, apple tiger skin disease, apple bitter leaf rot, apple leaf spot, apple leaf rot, apple leaf spot, apple leaf rot, apple leaf scald, apple leaf spot, apple leaf rot, apple leaf spot, peanut leaf, Apple pox disease, apple blight, apple core rot, grape white rot, grape anthracnose, grape downy mildew, grape anthracnose, grape brown spot, grape spike brown blight, grape gray mold, jujube witches broom, jujube fruit rot, fruit tree root canker, seedling diseases of solanaceous vegetables, tomato virus diseases, tomato leaf mold, tomato canker, tomato wilt, tomato yellow wilt, tomato early blight, tomato spot blight, tomato leaf mold, tomato gray mold, tomato powdery mildew, tomato brown rot, tomato soft rot, pepper blight, pepper scab, cucumber downy mildew, melon blight, melon powdery mildew, cucumber scab, cucumber blight, cucumber sclerotinia rot, cucumber angular leaf spot, cruciferous soft rot, cruciferous downy mildew, cruciferous black spot, grape gray mold, grape gray spot, grape gray mold, grape gray spot, grape leaf spot, grape gray mold, grape leaf spot, grape leaf mold, tomato leaf spot, tomato leaf mold, leaf, Cruciferae clubroot, cruciferae sclerotinia sclerotiorum, ginseng sclerotinia sclerotiorum, cruciferae black rot, peanut leaf spot, strawberry powdery mildew, banana leaf spot, banana vascular wilt, banana bunching top disease, banana tea leaf heart rot, banana anthracnose, banana scab, rape sclerotinia sclerotiorum, rape downy mildew, sesame wilt, sesame stem blight, sunflower sclerotinia sclerotiorum, sunflower black spot, peach plum brown rot, peach anthracnose, peach blossom blight, peach leaf shrinkage disease, peach tree rot disease, peach apricot scab, peach tree gummosis, persimmon angular leaf spot disease, persimmon round spot disease, persimmon anthracnose, strawberry gray mold, Chinese chestnut dry blight, walnut black spot disease, walnut anthracnose disease, hawthorn flower rot disease, kiwi fruit canker disease, bean bacterial blight, bean rust disease, bean anthracnose, bean wilt disease, celery spot blight, celery early blight, onion purple spot disease or ginger blast and the like.
Preferably, in the application of the bactericidal composition, the plant diseases are ginseng sclerotinia rot, Chinese cabbage sclerotinia rot, strawberry gray mold, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia rot, tomato gray mold, tomato sclerotinia rot, eggplant gray mold, pepper gray mold or pepper sclerotinia rot.
Preferably, in the application of the bactericidal composition, the plant diseases are ginseng sclerotinia rot, Chinese cabbage sclerotinia rot, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia rot, tomato sclerotinia rot, eggplant gray mold, pepper gray mold or pepper sclerotinia rot.
The invention has the beneficial effects that:
1) the synergistic effect is remarkable: in the above-mentioned bactericidal composition of the present invention, the bipyramid can form a synergistic effect with prothioconazole, boscalid and fluazinam, that is, the synergistic effect of the two components in the composition can make the total effect greater than or more durable than the sum of the effects obtained by the two (or more) components alone. In a method of providing control of plant disease wherein synergy is exhibited by a combination of active ingredients applied to a plant or seed, the active ingredients are applied in a synergistic weight ratio. The bactericidal composition can be used for preventing and treating ginseng sclerotinia rot, strawberry gray mold, cucumber powdery mildew or cucumber sclerotinia rot in a synergistic manner, and an unexpected synergistic effect is obtained.
2) The use cost is reduced: the biphenylpyrazinamide and the prothioconazole, the boscalid or the fluazinam have obvious synergistic effect and obviously improved disease prevention effect, so that the application times are reduced, the use cost is reduced, the time and the labor are saved, and the economic benefit and the social benefit are obvious;
3) the development of resistance is delayed: the effective components of the invention, such as the biphenyl pyrazinamide, the prothioconazole, the pyrimethanil or the fluazinam, have different action mechanisms and bactericidal spectrums, the bactericidal effect is good, the use dosage of a single medicament is obviously reduced, the generation of pathogenic bacteria resistance is favorably delayed, the use range of the product is expanded, and the service life of the product is prolonged;
4) and (3) reduction of environmental pollution: the biphenyl pyrazinamide and prothioconazole, boscalid or fluazinam have excellent synergistic effect and disease prevention effect, so that the effects of preventing and controlling germs, resisting bacteria or inhibiting bacteria are improved, the prevention spectrum is expanded, the medicine using times can be reduced, the application dosage is obviously reduced, the environmental pollution is reduced, and the safety to people and livestock is improved.
Detailed Description
Example 1: experiment of combined toxicity effect of different compounding agents on ginseng sclerotinia rot
The test takes the sensitive strain of the ginseng sclerotinia sclerotiorum as an object to carry out formula screening of the compound medicament. After the related biphenyl pyrazinamide, prothioconazole, boscalid and fluazinam are dissolved by acetone, experiments are designed according to the mass ratio.
The inhibition rate of the bactericidal composition of the bactericides Bispyrazine, prothioconazole, pyrimethanil and fluazinam single dose and the active ingredients with different weights is determined by referring to the Sunweper (1960) cotoxicity coefficient method.
The indoor combined toxicity test adopts a toxic medium method, namely adding a quantitative test agent (calculated according to effective components) into a PDA culture medium, taking the PDA culture medium without the agent as a control, cooling, inoculating sclerotinia sclerotiorum to be tested, after inoculating for 48 hours, respectively measuring the growth diameters of the control and the colonies treated differently by a cross method, and calculating the inhibition rate and the Effective Concentration (EC)50) The value is obtained.
Then according to the concentration logarithm-hyphal growth inhibition rate probability value analysis (Bliss) method, using DPS2000 data processing software to obtain virulence regression equation and inhibition medium concentration (EC)50) The value of (c). Then, the co-toxicity coefficient (CTC) of each mixture was determined according to the method described in Sun Yunpei (Sun).
The Actual Toxicity Index (ATI) of mixed preparation is standard preparation EC 50/mixed preparation EC50×100
Theoretical virulence index (TTI) of mixed preparation ═ sigma (virulence index of single preparation x the content of single preparation in mixed preparation)
The co-toxicity coefficient (CTC) of mixed preparation is mixed preparation actual toxicity index/mixed preparation theoretical toxicity index x 100
When the cotoxicity coefficient CTC is more than 120, the synergistic effect is achieved; 80 < CTC < 120, for addition; and if CTC is less than 80, antagonism is obtained.
Results of the indoor-linked and virulence assays of the single agents of the biphenylpyrazinamide, the prothioconazole, the boscalid and the fluazinam and the compositions thereof against the ginseng sclerotinia strain are shown in the following tables 1, 2 and 3.
Table 1: indoor joint toxicity determination method of biphenyl pyrazinamide and fluazinam composition on ginseng sclerotinia sclerotiorum
| Name of medicament | Regression equation of virulence | EC50(mg/kg) | Correlation coefficient | Co-toxicity coefficient | Evaluation of |
| Fluazinam | Y＝4.9310+0.3138X | 1.6591 | 0.9507 | ---- | --- |
| Biphenyl pyrazinamide | Y＝4.2346+0.5938X | 19.4530 | 0.8682 | ----- | ---- |
| Biphenyl pyrazinamide fluazinam 80:1 | Y＝0.7734+3.8775X | 12.3038 | 0.9791 | 139.40 | Efficiency enhancement |
| Biphenyl pyrazinamide and fluazinam 20:1 | Y＝4.9684+0.2517X | 1.3352 | 0.9446 | 964.40 | Efficiency enhancement |
| Biphenyl pyrazinamide and fluazinam 10:1 | Y＝4.9468+0.5977X | 1.2275 | 0.9277 | 802.41 | Efficiency enhancement |
| Biphenyl pyrazinamide + fluazinam 1:1 | Y＝5.0406+0.4215X | 0.8011 | 0.9849 | 381.66 | Efficiency enhancement |
| Biphenyl pyrazinamide and fluazinam 1:10 | Y＝4.8311+1.2982X | 1.3493 | 0.9162 | 134.11 | Efficiency enhancement |
| Biphenyl pyrazinamide and fluazinam 1:40 | Y＝4.9082+0.5046X | 1.5203 | 0.7914 | 111.62 | Addition of |
| Biphenyl pyrazinamide and fluazinam 1:80 | Y＝4.9655+0.3879X | 1.2273 | 0.9382 | 136.73 | Efficiency enhancement |
Table 2: biphenyl pyrazinamide: indoor combined toxicity determination method of prothioconazole to ginseng sclerotinia sclerotiorum
| Name of medicament | Regression equation of virulence | EC50(mg/kg) | Correlation coefficient | Co-toxicity coefficient | Evaluation of |
| Prothioconazole | Y＝3.8148+0.7121X | 46.1714 | 0.9777 | --- | ---- |
| Biphenyl pyrazinamide | Y＝4.2346+0.5938X | 19.4530 | 0.8682 | ---- | ---- |
| Biphenyl pyrazinamide and prothioconazole 1:10 | Y＝4.4196+0.5046X | 14.1300 | 0.9367 | 290.49 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 1:3 | Y＝4.7376+0.3434X | 5.8093 | 0.9252 | 591.63 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 3:1 | Y＝4.7694+0.2925X | 6.1429 | 0.8729 | 370.24 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 9:1 | Y＝4.4156+0.479X | 16.600 | 0.9921 | 124.38 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 20:1 | Y＝3.5537+1.2064X | 15.8047 | 0.8625 | 126.44 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 40:1 | Y＝4.7960+0.3641X | 3.6332 | 0.9899 | 543.09 | Efficiency enhancement |
| Biphenyl pyrazinamide + prothioconazole 80:1 | Y＝4.8434+0.1995X | 6.0948 | 0.9098 | 321.47 | Efficiency enhancement |
Table 3: biphenyl pyrazinamide: boscalid indoor combined toxicity determination method for ginseng sclerotinia sclerotiorum
| Name of medicament | Regression equation of virulence | EC50(mg/ kg) | Correlation system Number of | Co-virus system Number of | Evaluation of |
| Biphenyl pyrazinamide | Y＝4.2346+0.5938X | 19.4530 | 0.8682 | ---- | --- |
| Boscalid | Y＝4.3440+0.4073X | 40.7950 | 0.9715 | ---- | ---- |
| 1:1 of biphenyl pyrazinamide and boscalid | Y＝4.2619+0.6718X | 12.5513 | 0.9807 | 209.89 | Efficiency enhancement |
| 1:20 of biphenyl pyrazinamide and boscalid | Y＝4.2746+0.7488X | 9.3125 | 0.8386 | 416.32 | Efficiency enhancement |
| 1:40 of biphenyl pyrazinamide and boscalid | Y＝4.8903+0.2690X | 2.5574 | 0.9719 | 1553.60 | Efficiency enhancement |
| 1:80 of biphenyl pyrazinamide and boscalid | Y＝3.8465+1.0028X | 14.1334 | 0.9003 | 284.79 | Efficiency enhancement |
Example 2: field efficacy test of different compound agents for preventing and treating gray mold, powdery mildew, sclerotinia sclerotiorum and the like
Respectively adopting single agents of biphenyl pyrazinamide, prothioconazole, boscalid and fluazinam and a composition preparation thereof to carry out spray treatment at the initial stage of the gray mold of the strawberry in a protected area, carrying out application twice at intervals of 7 days, and investigating the control effect 15 days after the second application; spraying twice at 7 days intervals at the early stage of powdery mildew of cucumber, and investigating 15 days after application; spraying twice at the initial stage of sclerotinia rot of cucumber in protected area, and investigating at 7-day intervals, and after 20-day investigation, spraying twice at the initial stage of gray mold of cucumber, and investigating at 7-day intervals, and after 20-day investigation; spraying at the early stage of strawberry powdery mildew, applying the pesticide twice at intervals of 7 days, and investigating 15 days after the pesticide application; spraying at the early stage of Chinese cabbage sclerotinia sclerotiorum, applying twice at intervals of 7 days, and investigating 25 days after application; spraying at the early stage of tomato gray mold generation, applying the pesticide twice at intervals of 7 days, and investigating 15 days after pesticide application; spraying at the early stage of tomato sclerotiniose occurrence, applying the pesticide twice at intervals of 7 days, and investigating 15 days after pesticide application; spraying twice at the initial stage of gray mold of eggplant, investigating at intervals of 7 days after application, and investigating at intervals of 7 days at the initial stage of gray mold of pepper, spraying twice at intervals of 7 days, investigating at intervals of 15 days after application; spraying at the initial stage of the occurrence of the capsicum sclerotinia sclerotiorum, applying the pesticide twice at intervals of 7 days, and investigating 15 days after the pesticide is applied; see tables 4-14 below for results.
The single-dose preparation and the compound preparation used for preventing and treating each disease have the same dosage form, and are generally suspending agents. The formulation is not the key for verifying the synergistic effect of the compound preparation, the preparation sometimes needs to be adjusted according to actual crops and diseases, but the formulation used in all experiments aiming at each disease is the same regardless of the adjustment, and the auxiliary agent is not changed except for the change of the active ingredients so as to ensure the consistency of the active ingredients.
According to the efficacy evaluation mode of the Gowing method, the calculation formula is as follows: e0X + Y (100-X)/100, wherein X is A single-agent control effect (%), Y is B single-agent control effect (%), E is A, B actual control effect (%) of two single-agents in a mixed mode, and when E-E is used0>10 hours is synergistic, E-E0<10 hours is a decrease, E-E0Within + -10 is additive.
Table 4: field efficacy test of different compound agents for preventing and treating strawberry gray mold
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment of preventing and treating the gray mold of the strawberry with a single agent is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the gray mold of the strawberry.
Table 5: field efficacy test of different compound agents for preventing and treating cucumber powdery mildew
The synergistic comparison of the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the single-agent cucumber powdery mildew control treatment room is carried out, the actual control effects are all more than 10 greater than the theoretical control effects, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic control of the cucumber powdery mildew.
Table 6: field efficacy test of different compound agents for preventing and treating cucumber sclerotinia rot
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment room for controlling the cucumber sclerotinia by using a single agent is carried out, the actual control effects are all more than 10 greater than the theoretical control effects, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic control of the cucumber sclerotinia.
Table 7: field efficacy test of different compound agents for preventing and treating cucumber gray mold
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment of controlling the gray mold of the cucumber by using a single agent is carried out, the actual control effects are all more than 10 greater than the theoretical control effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic control of the gray mold of the cucumber.
Table 8: field efficacy test of different compound agents for preventing and treating strawberry powdery mildew
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the single-agent treatment room for preventing and treating the strawberry powdery mildew is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the strawberry powdery mildew.
Table 9: field efficacy test of different compound agents for preventing and treating Chinese cabbage sclerotinia rot
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the single-dose treatment for preventing and treating the Chinese cabbage sclerotinia is carried out, the actual prevention effects are all more than 10 greater than the theoretical prevention effects, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the Chinese cabbage sclerotinia.
Table 10: field efficacy test of different compound agents for preventing and treating tomato gray mold
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment of preventing and treating the gray mold of the tomatoes with a single dose is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the gray mold of the tomatoes.
Table 11: field efficacy test of different compound agents for preventing and treating tomato sclerotinia rot
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment room for preventing and treating the tomato sclerotinia with a single dose is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the tomato sclerotinia.
Table 12: field efficacy test of different compound agents for controlling gray mold of eggplant
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment for controlling the gray mold of the eggplant with a single dose is carried out, the actual control effects are all more than 10 greater than the theoretical control effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic control of the gray mold of the eggplant.
Table 13: field efficacy test of different compound agents for preventing and treating gray mold of capsicum
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the treatment of preventing and treating the gray mold of the pepper with a single dose is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid can realize the synergistic prevention and treatment of the gray mold of the pepper.
Table 14: field efficacy test of different compound agents for preventing and treating capsicum sclerotium disease
The synergistic comparison between the compound preparation of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid and the single-dose treatment for preventing and treating the capsicum sclerotinia disease is carried out, the actual prevention effect is more than 10 times greater than the theoretical prevention effect, and the synergistic prevention and treatment of the capsicum sclerotinia disease can be realized by the compound composition of the biphenylpyrazinamide and the fluazinam, the prothioconazole and the boscalid.
Claims (10)
1. The bactericidal composition is characterized by comprising a bactericidal active ingredient A and a bactericidal active ingredient B, wherein the bactericidal active ingredient A is a compound shown as the following formula (I):
the bactericidal active ingredient B is fluazinam, and the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 80:1, 8:1 or 1: 80.
2. The bactericidal composition of claim 1, wherein the sum of the weight of bactericidal active ingredient a and bactericidal active ingredient B is 1-70% of the weight of the bactericidal composition.
3. The bactericidal composition according to claim 1, wherein the bactericidal composition comprises a third bactericidal component, the third bactericidal component is one selected from the group consisting of amide bactericides, dicarboximide bactericides, triazole bactericides, imidazole bactericides, oxazole bactericides, thiazole bactericides, morpholine bactericides, pyrrole bactericides, pyridine bactericides, pyrimidine bactericides, quinazolinone bactericides, carbamate bactericides, organic phosphorus bactericides, thiocarbamate bactericides and copper bactericides, and the third bactericidal component accounts for 1-50 wt% of the bactericidal composition.
4. The bactericidal composition according to claim 1, wherein the bactericidal composition comprises a pesticide carrier and a pesticide adjuvant, the sum of the weight of the pesticide carrier and the weight of the pesticide adjuvant accounts for 1-90% of the weight of the bactericidal composition, the pesticide carrier is a liquid carrier or a solid carrier, and the pesticide adjuvant is one or more selected from an emulsifier, a dispersant, a wetting agent, a thickener, an antifoaming agent, an oxidant, an antifreezing agent and a disintegrant.
5. The bactericidal composition according to any one of claims 1 to 4, which is prepared into a composition preparation in the form of emulsifiable concentrate, suspending agent, water dispersible granule, aqueous emulsion, microemulsion, soluble liquid, wettable powder, oil suspending agent, suspended seed coating agent or granule.
6. The application of the bactericidal composition is to control plant diseases, wherein the plant diseases are ginseng sclerotinia rot, Chinese cabbage sclerotinia rot, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia rot, tomato sclerotinia rot, eggplant gray mold, pepper gray mold or pepper sclerotinia rot, the bactericidal composition comprises a bactericidal active ingredient A and a bactericidal active ingredient B, and the bactericidal active ingredient A is a compound shown in the following formula (I):
the bactericidal active ingredient B is fluazinam, and the weight ratio of the bactericidal active ingredient A to the bactericidal active ingredient B is 20:1, 8:1 or 1: 20.
7. Use according to claim 6, characterized in that the sum of the weight of the bactericidal active ingredient A and the bactericidal active ingredient B accounts for 1 to 70% of the weight of the bactericidal composition.
8. The use according to claim 6, characterized in that the bactericidal composition contains a third bactericidal component, the third bactericidal component is selected from one of amide bactericides, dicarboximide bactericides, triazole bactericides, imidazole bactericides, oxazole bactericides, thiazole bactericides, morpholine bactericides, pyrrole bactericides, pyridine bactericides, pyrimidine bactericides, quinazolinone bactericides, carbamate bactericides, organic phosphorus bactericides, thiocarbamate bactericides and copper bactericides, and the third bactericidal component accounts for 1-50% of the weight of the bactericidal composition.
9. The use according to claim 6, characterized in that the bactericidal composition comprises a pesticide carrier and a pesticide adjuvant, the sum of the weight of the pesticide carrier and the pesticide adjuvant accounts for 1-90% of the weight of the bactericidal composition, the pesticide carrier is a liquid carrier or a solid carrier, and the pesticide adjuvant is one or more selected from the group consisting of an emulsifier, a dispersant, a wetting agent, a thickener, an antifoaming agent, an oxidant, an antifreeze and a disintegrant.
10. A method for controlling plant diseases by applying the fungicidal composition according to any one of claims 1 to 2, in a fungicidally effective amount to the stem and leaf parts, roots or plant seeds by spraying, root application or seed coating, wherein the plant diseases are ginseng sclerotinia, Chinese cabbage sclerotinia, strawberry powdery mildew, cucumber gray mold, cucumber sclerotinia, tomato sclerotinia, eggplant gray mold, pepper gray mold or pepper sclerotinia.
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