CN116711727A - Sterilization composition and application thereof - Google Patents

Sterilization composition and application thereof Download PDF

Info

Publication number
CN116711727A
CN116711727A CN202310611109.8A CN202310611109A CN116711727A CN 116711727 A CN116711727 A CN 116711727A CN 202310611109 A CN202310611109 A CN 202310611109A CN 116711727 A CN116711727 A CN 116711727A
Authority
CN
China
Prior art keywords
alkyl
alkoxy
halo
halogen
halogenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310611109.8A
Other languages
Chinese (zh)
Inventor
王军锋
李志念
刘君丽
关爱莹
兰杰
刘长令
孙芹
单忠刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
Original Assignee
Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Yangnong Chemical Co Ltd, Shenyang Sinochem Agrochemicals R&D Co Ltd filed Critical Jiangsu Yangnong Chemical Co Ltd
Publication of CN116711727A publication Critical patent/CN116711727A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The application belongs to the field of agricultural bactericides, and in particular relates to a bactericidal composition and application thereof. The composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99:1; the active component A is one or more of pyrimidine-containing substituted pyrazole compounds or salts thereof, and the active component B is selected from a bactericide. The bactericidal composition is particularly suitable for preventing and controlling various plant pathogenic fungi and bacterial diseases.

Description

Sterilization composition and application thereof
The application is a re-divisional application aiming at a divisional application 202210553242.8 of Chinese patent 202011314120.0; the application date of the Chinese patent 202011314120.0 is 11 months and 20 days in 2020, and the application is named: sterilization composition and application thereof, publication number: CN112825859a, publication No. 202210553242.8 of chinese application: CN114903046a; the applicant has filed a divisional application for the chinese application patent 202210553242.8 again due to the singleness problem pointed out by the examiner in the chinese application patent 202210553242.8 application.
Technical Field
The application belongs to the field of agricultural bactericides, and particularly relates to a bactericidal composition containing pyrimidine substituted pyrazole compounds and a bactericide and application thereof.
Background
Patent WO2016184378 discloses pyrimidine-containing substituted pyrazoles and their use, wherein compounds of the following general formula I-A, I-B are reported to have good activity against a variety of diseases.
Respiratory depressant bactericides, nucleic acid metabolism depressant bactericides, cell wall synthesis depressant bactericides, signal transduction depressant bactericides, cytoskeletal and motor protein inhibitor bactericides, sterol biosynthesis depressant bactericides, phospholipid synthesis depressant bactericides, cell wall synthesis depressant bactericides and methionine biosynthesis depressant bactericides are bactericides widely used in agricultural production and have remarkable control effects. Because the action site is single, the field efficacy of part of varieties is obviously reduced after long-term repeated use. The multi-site inhibitor bactericide is a broad-spectrum protective bactericide, but the bactericide has poor therapeutic activity and large field dosage.
In the practice of using bactericides, people often find that a medicament has good disease prevention effect in the early stage, but the medicament dosage is gradually increased along with the increase of the use times, and the medicament effect is slightly improved, and sometimes even the disease prevention effect is completely lost. The main reason is that the pathogenic bacteria group is changed, namely, part of pathogenic bacteria obtain drug-resistant plasmid through mutation to generate drug resistance, and dominant group is gradually formed in natural selection, so that the drug effect of the bactericide is reduced. At the same time, it is recognized that after the pesticide is applied, a portion of the pesticide may be scattered on the soil or into the air or along with rainwater and farmland drainage into rivers and lakes, causing environmental pollution. Therefore, there is an urgent need for pesticide products that have high efficacy, low dosage, little environmental pollution, and can delay the drug resistance of pathogenic bacteria.
The combined application of pesticides is an important means for delaying the generation of drug resistance of pathogenic bacteria and is also an effective method for reducing the pesticide dosage. The scientificity of the combined application of bactericides depends not only on the control object and the action mechanism, but also on the combined action property of the medicines after being mixed. Therefore, various restriction factors exist in developing a high-efficiency bactericide composition with complementary action and remarkable synergism, and the success rate is extremely low.
Disclosure of Invention
The invention aims to provide a synergistic bactericidal composition containing pyrimidine substituted pyrazole compounds and a bactericide and application thereof.
In order to achieve the above purpose, the invention adopts the technical scheme that:
a bactericidal composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99:1;
wherein the active component A is one or more of pyrimidine-containing substituted pyrazole compounds or salts thereof; the active component B is selected from a bactericide.
The active component A is a compound shown in a general formula I-A or I-B or a salt thereof:
wherein:
R 1 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkynyl, C 3 -C 4 Alkenyloxy, halogenated C 3 -C 4 Alkenyloxy, C 3 -C 4 Alkynyloxy, halogenated C 3 -C 4 Alkynyloxy, C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylaminocarbonyl, halo C 1 -C 4 Alkylaminocarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl or C 1 -C 4 Alkylthio C 1 -C 4 An alkyl group;
R 2 selected from hydrogen, halogen, cyano, nitroRadicals, amino radicals, carboxyl radicals, formyl radicals, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group;
R 3 selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkynyl, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, C 1 -C 4 Alkylsulfinyl, halo C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, haloC 1 -C 4 Alkylsulfonyl, C 1 -C 4 Alkylaminosulfonyl, di (C) 1 -C 4 Alkyl) sulfamoyl, C 1 -C 4 Alkylsulfonylaminocarbonyl, C 1 -C 4 Alkylcarbonylaminosulfonyl, C 3 -C 4 Cycloalkyl-oxycarbonyl, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylcarbonyl C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, C 1 -C 4 Alkylaminocarbonyl, di (C) 1 -C 4 Alkyl) aminocarbonyl, C 2 -C 4 Alkenyloxycarbonyl, C 2 -C 4 Alkynyloxycarbonyl, C 1 -C 4 Alkoxy C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylaminothio, di (C) 1 -C 4 Alkyl) aminothio, arylcarbonyl C 1 -C 4 Alkyl, arylcarbonyl, aryloxycarbonyl, arylC 1 -C 4 Alkyloxycarbonyl, aryl C 1 -C 4 Alkyl, heteroaryl carbonyl C 1 -C 4 Alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroaryl C 1 -C 4 Alkyloxycarbonyl or heteroaryl C 1 -C 4 An alkyl group;
R 4 、R 5 may be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 4 、R 5 C connected with it can also form C 3 -C 4 Is a ring of (2);
R 6 、R 7 may be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 6 、R 7 C connected with it can also form C 3 -C 4 Is a ring of (2);
R 8 、R 9 may be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl, unsubstituted or substituted by 1-5R 11 Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;
R 11 selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, C 2 -C 4 Alkenyloxy, halogenated C 2 -C 4 Alkenyloxy, C 2 -C 4 Alkynyloxy, halogenated C 2 -C 4 Alkynyloxy, C 1 -C 4 Alkylsulfonyl, haloC 1 -C 4 Alkylsulfonyl, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio carbonyl C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio carbonyl C 1 -C 4 Alkyl, C 1 -C 4 Alkylcarbonyloxy, haloC 1 -C 4 Alkylcarbonyloxy, C 1 -C 4 Alkoxycarbonyloxy, halo C 1 -C 4 Alkoxycarbonyloxy, C 1 -C 4 Alkylsulfonyloxy, halogenated C 1 -C 4 Alkylsulfonyloxy, C 1 -C 4 Alkoxy C 1 -C 4 Alkoxy or halo C 1 -C 4 Alkoxy C 1 -C 4 An alkoxy group; n is selected from integers from 0 to 5, R when n is greater than 1 11 May be the same or different;
R 14 、R 15 、R 16 or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy or C 3 -C 4 Cycloalkyl;
w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or C 1 -C 4 An alkylsulfonyl group;
the salts of the pyrimidine-containing substituted pyrazole compounds are salts formed by compounds shown in the general formula I-A or I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
the active component B is one or more selected from respiratory inhibitor bactericide, nucleic acid metabolism inhibitor bactericide, cell wall synthesis inhibitor bactericide, signal transduction inhibitor bactericide, cytoskeletal and kinesin inhibitor bactericide, sterol biosynthesis inhibitor bactericide, phospholipid synthesis inhibitor bactericide, methionine biosynthesis inhibitor bactericide, multi-site inhibitor bactericide and bactericide with unknown action mechanism.
When the active component A is a compound of the general formula I-A or a salt thereof, preferably, the composition is an active component A and an active component B in a weight ratio of 1:50 to 50:1;
wherein the active component A is selected from one or more of compounds in the general formula I-A or salts thereof;
wherein: r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 Alkylthio; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl or C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-A is the salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from flumorph (fluororph) B41, dimethomorph (dimethomorph) B42, mandipromine (mandipromil) B43, zoxamide B44, metalaxyl (metalaxyl) B45, metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cymoxanil B48, benalaxyl (benalaxyl-M) B49, flufenamid (flufenamid) B50, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, cyflufenamid (cyflufenamid) B53, cycloxamide (fenxamid) B54, dicyclopyramid (dicyclopyramid) B55, bupirimate (bupirimate) B56, dimethamam (azoxystrobin) B59, pyrim (pyrim) B58, pyrimethanil B59, pyrimethanil (pyrimethanil) Xin Saitong (octyinone) B60, furalamide (ofurace) B61, fenazamate (chinomethionat) B62, oxadixyl (metaxyl) B63, furalaxyl (furalaxyl) B64, fludioxonil (fluxotail) B65, fenpiclonil (fenpiclonil) B66, iprodione B67, procymidone (procymidone) B68, meclozol (meclozolin) B69, ethiprole (chlorozolate) B70, dimethachlon (dimethachlon) B71, dimethachlon (vinazozol) B72, diethofencarb) B73, benzofuranone (metfanole) B74, pyrifenone B75, carbendazim (carbosulfazin) B76, methimazole (methyizol) B77, myclobutanil B79, myclobutanil B80, myclobutanil B79 Thiabendazole (thiabendazole) B81, thiabendazole (thiophanate) B82, pencycuron (pencycuron) B83, epoxiconazole (etaconzole) B84, pyripyroxime (ethaboxam) B85, fenarimol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpropimorph (fenpropimorph) B89, fenpropimorph (fenpropimorph) B90, triflumizole (mefenazamine) B91, flubenazezole (nuarconazole) B92, imidazole (oxaconzole) B93, pyrifos-tiazole (penflufenamate) B94, prochloraz (prochloraz) B95, myclobutanil (spiroxamine) B96, pyrimorph (fenpropimorph) B97, pyrimorph (oxazine) B101, morpholine (oxazine) B98, morpholine (oxazine) B100, morpholine (pyrimorph) B101, morpholine (pyrimorph) B100; imazalil (triamcinol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumizole) B105, ipfentrifluconazole B106, chloronitrobenzene (tecnazene) B107, difenoconazole (chloroni) B108, chloronitaline (dichloran) B109, biphenyl (biphenyl) B110, diphenphos (edifenphos) B111, carbendazim (ethyl) B112, iodopropynylbutyl methyl (iodocarb) B113, iprobenfos (iprobenfos) B114, isoprothiolane (isoprothiolane) B115, oxathiazopyr (oxapyrifos) B116, 35 117, propamocarb) B118, pyricarb (procarbazone) B119, methimazole (methyl) B121, pyriphos (methyl) B120, pyriphos (pyriphos) B122 Benthiavalicarb-isopropyl B123, polyoxin B124, valicarb (valicalate) B125, pyrimorph (pyrimorph) B126, blasticidin (blasticidin-s) B127, cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, cyprodinil (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (stremycin) B132, oxytetracycline (oxyetracycloine) B133, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (proepeneb) B137, mancozeb) B138, ambam (amsamson) B, sodium (napecoram) B141, and thiometiram (zeb) B142 mancozeb (mancoppe) B143, furbenomyl (cufraneb) B144, sulfur (sulfur) B145, dichlormid (anilazine) B146, captan (captan) B147, acephate (chinomethoate) B148, chlorothalonil (chlorothalonil) B149, benfomesalamine (dichlorfluanid) B150, tolofloxamide (tolofloxamid) B151, dithianon (dithianon) B152, fluoroimide (fluorooimide) B153, thiodicarb (methiocarb) B154, captan (captol) B155, folpet (folpet) B156, biguanide (iminoctadine) B157, guazatine (guazatine) B158, zinc (zizozole) B159, quinoline (copper) B160-copper (copper) 38, copper (copper) B162, copper (copper) 38 One or more of picarbazox B163, amipyrifen B164, metyltetraprole B, dodine B166, pyridachlometyl B167, pyridaben (dichlomerizine) B168, validamycin (validamycin) B169, azomethizone (ferimzone) B170, tebufloquin B171, imidazoxide B172, quinfumelin B173, ipflufenon B174, dipmometatron B175, tecloftalam B176.
Further preferably, the composition is an active component A and an active component B in a weight ratio of 1:20 to 20:1;
wherein the active component A is one or more of compounds shown in the general formula I-A or salts thereof;
wherein R is 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino or haloC 1 -C 4 An alkylamino group; n is selectedAn integer from 0 to 5, when n is 0, there is no substituent on the benzene ring; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from flumorph (fluororph) B41, dimethomorph (dimethomorph) B42, mandiprimide B43, zoxamide B44, metalaxyl (metalaxyl-M) B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, benalaxyl-M) B49, thiabendazole (tiadinil) B51, ethaboxam (ethaboxam) B52, bupirimate (bupirimate) B56, dimethpyrim (dimethpyrimol) B57, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, xin Saitong (oxacillin) B60, furalamide (ofacil) B61, fluquinconazole (62), fludioxonil (fludioxonil) B67 procymidone B68, procymidone B71, dimethachlon B71, vinyldimethirin B72, diethofencarb B73, benomyl B74, pyrifenone B75, carbendazim B76, thiophanate-methyl B77, fenpropidin B78, benomyl B79, pyribenzoxim B85, pyribenzoxim B86, fenbuconazole B87, fenpropidin B88, fenpropidone B90, triflumizole B91, fluoxastrobin B92, profenoxypyrim B94, pyriproxyfen B93, pyriproxyfen B92, pyriproxyfen B93, pyriproxyfen B78, pyriproxyfen B71, pyriproxyfen B86, fenpropiconazole B87, fenpropiconazole B74, pyriproxyfen B90, fenpropiconazole B76, fenpropiconazole B77, fenpropiconazole B75, fenpropiconazole B92, fenpropiconazole B75, fenpropiconazole B92, and fenpropiconazole B95 Spiroxamine (spiroxamine) B96, boscalid (pyrisoxazole) B97, simeconazole (simeconazole) B104, ipfentrifluconazole B106, diphenfos (edifenphos) B111, iprobenfos (iprobofos) B114, isoprothiolane (isoproplift) B115, oxathiapyr-ethyl (oxathiapiprolin) B116, fluoxapiproline B, propamocarb (propamocarb) B118, thiodicarb (prothiocarb) B119, pyrazophos (pyrazophos) B120, pentachloronitrobenzene (quintozene) B121, tolclofos-methyl) B122, benthiavalicarb-isopropylpyridinium (tolyphos) B123, polyoxin (polyoxin) B124, valicarb (valicarb) B125, butamol (pyriftalide) B126, pyriminol (pyriminol) B126, pyriminomethyl) B128, pyriminol (pyriminol) B128; cyprodinil (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, maneb (milneb) B142, mancozeb (mancozeb) B143, thioflavin (sulfophur) B145, dichlormid (anilazine) B146, captan (captan) B147, chlorothalonil (chlorthalide) B149, benzosulfamide (dichloranid) B150, tolofloride (tolfenid) B151, sulfob (meticol) B154, sulfamethoxide (sulfamide) B155, and thioflavin (copper-B) 159, and (copper-pyrithione) B159 One or more of thiocopper (thiodiazole-coupler) B161, noncopper (cuppric nonyl phenolsulfonate) B162, picarbazone B163, amipyrifen B164, metyltetraprole B, pyridachlometyl B167, validamycin (validamycin) B169, azomethizone (ferimzone) B170, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipymetrizole B175, and teclofthalam B176.
Still further preferably, the composition is an active component A and an active component B in a weight ratio of 1:10 to 10:1;
wherein the active component A is selected from one or more of compounds in the general formula I-A or salts thereof;
wherein R is 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r is R 4 、R 5 Can be the same or different, respectively selectFrom hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 6 、R 7 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 8 、R 9 May be the same or different and are each selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and is selected from hydrogen, halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from flumorph (fluororph) B41, dimethomorph (dimethomorph) B42, mandiproteimide (mandipropend) B43, zoxamide (zoxamide) B44, metalaxyl (metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cymoxanil (cymonoil) B48, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, bupirimate (bupirimate) B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, xin Saitong (octhiazolone) B60, quinidone (carboxin) B62, fludioxonil (fludioxonil) B65, iproviprovalic (iprovalicarb) B67, myclobutanil (procyanine) B68, pyrimethanil (pyrimethanil) B74, pyrimethanil (pyrimethanil) B75, pyrimethanil (pyrimethanil) B thiophanate-methyl B77, myclobutanil B78, fenbuconazole B87, penfluvalicazole B91, fluopyram B92, prochloraz B95, spiroxamine B96, pyribenzoxazole B97, simeconazole B104, ipfentrifluconazole B, iprobenfos B114, isoprothiolane B115, oxathiabendazole B116, 35117, propamocarb B118, pentachloronitrobenzene B121, methyl-phosphorus B, benzofuranole B122, valicarb 125, and valicarb-125, pyrimorph (pyrimorph) B126, cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, zineb (zineb) B134, mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, sulfur (sulfur) B145, captan (captan) B147, chlorothalonil (chlorothalonil) B149, benzofuranodide (dichlorfluanid) B150 one or more of captafol B155, folpet B156, zinc thiazole B159, copper quinoline B160, copper sulfide B161, copper nonate (cuppric nonyl phenolsulfonate) B162, picartrazol B163, aminopyrafen B164, metyltetraprole B, pyridachlometyl B, validamycin B169, tebufloquin B171, quinofiverin B173, ipflufequin B174, dipyrthrone B175, teclofttham B176.
When the active component A is a compound of the general formula I-B or a salt thereof, preferably, the composition is an active component A and an active component B in a weight ratio of 1:50 to 50:1;
wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl or halo C 2 -C 4 Alkynyl; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 Alkylthio; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-B is the salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from the group consisting of dinotefuran (dinocap) B40, flumorph (flumarph) B41, dimethomorph (dimethomorph) B42, mandipropamid (mandipropamid) B43, zoxamide (zoxamide) B44, metalaxyl (metalaxyl) B45, metalaxyl (metalaxyl-M) B46, iprovalicarb) B47, cymoxanil (cymoxanil) B48, benalaxyl-M) B49, sulfenamid (fluflufenamid) B50, tiadinil (tiadinil) B51, ethaboxam (ethaboxam) B52, cyflufenamid (flufenamid) B53, cycloxamide (metalaxyl) B54, dicyclopentadienamide (dicyclopentadienamide) B55, bupirimate (bupirimol) B56, bupirimol (bupirimol) B56 hymexazol B59, xin Saitong (octhiazol) B60, furalamide B61, fenazazole B62, famoxadone B63, furalaxyl B64, fludioxonil B65, fenpiclonil B66, iprodione B67, procymidone B68, meclozol B69, ethiprole B70, dimethachlon B71, dimethachlon B72, diethofencarb B73, benzonitrile B74, pyrifenone B75, carbendazim B76, methimazole B77, methimazole B78, methimazole B77, pyribenzoxazol B59, pyribenzoxazol B60, methimazole B71, methimazole B70, methimazole B73, methimazole B74, methimazole B75, methimazole B76, methimazole B77, methimazole B76, methimazole Corncob (fuberidazole) B80, thiabendazole (thiabendazole) B81, thiabendazole (thiabendazole) B82, pencycuron (pencycuron) B83, epoxiconazole (ethaboxam) B84, pyripyroxime (ethane) B85, fenarimol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpropimorph (fenpropimorph) B89, fenpropimorph (fenpropimorph) B90, penflufenazole (mefenazamine) B91, flubenmid (nuarimol) B92, oxaimidazole (oxaconazol) B93, pyrifosfomate (pyrifos) B94, prochloraz (prochloraz) B95, spiroxamine (oxazine) B96, oxazine (oxaprozin) B98, oxaprozin (fenpiclonil) B98, fenpropimorph (fenpiclonil) B98; furazoles (bromoxynil) B101, imazalil (triamcinolone) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumizole) B105, ipfentrifluconazole B, chloronitrobenzene (tecnazene) B107, difenoconazole (chlororoneb) B108, chloronitramine (dichloran) B109, biphenyl (biphenyl) B110, diphenphos (edifenphos) B111, benomyl (etidiazole) B112, iodopropynyl butyl methyl ester (iodocarb) B113, iprobenfos) B114, isoprothiolane (isoprothiolane) B115, fluorothiazolopyzone (oxapyrithione) B, fluoxapiproline B, prochloraz (prochloraz) B118, pyrithione (pyrithione) B121, pyrithione (pyrithione) B120 Methanopyraz (tolclofos-methyl) B122, benthiavalicarb-isopropyl) B123, polyoxin (polyoxin) B124, valicarb (valicalate) B125, pyrimorph (pyrimorph) B126, blasticidin (blasticidin-s) B127, cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, cyprodinil (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, oxytetracycline (oxymacyclin) B133, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, mancozeb 138, mancozeb (bam) B140, mancozeb (141, and sodium thiomancozeb (141) a mancozeb B142, mancozeb B143, furben (cufraneb) B144, thioflavin B145, dichlormid (anilazine) B146, captan B147, acephate (chinomethoate) B148, chlorothalonil B149, benfomesafen (dichlorfluanid) B150, tolofloxacin (tolofloxarid) B151, dithianon B152, fluoroimide (fluorooimide) B153, thiodicarb (methacarb) B154, dipivoxine (captafol) B155, folpet (folpet) B156, octopamide (imazamate) B157, salts (guazatie) B158, thiazolaziridine (thiodicazole) B159, copper (copper) and thiodicarboxamide B161-thiodicazole (copper) B161 One or more of copper nonate (cuppric nonyl phenolsulfonate) B162, picarbazox B163, amipyrifen B164, metyltetraprole B165, dodine B166, pyridachlometyl B167, pyridalyne B168, validamycin B169, azomethizone B170, tebufloquin B171, imidazoxide B172, quinfumelin B173, ipflufenoquin B174, dipometronine B175, teclofthiam B176.
Further preferably, the composition is an active component A and an active component B in a weight ratio of 1:20 to 20:1;
wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 Alkoxy radicalA carbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino or haloC 1 -C 4 An alkylamino group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from benzovindesipram (benzovindesipram) B1, penflufen (penflufen) B2, isopyrazam (penflufen) B3, fluxapyroxad (fluxapyroxad) B4, flupyrazaamide (flufluflufluororam) B5, flufenamide (flufenazam) B6, fluxapyroxad (sedaxane) B7, pyrithione (penthiophanate) B8, boscalid (boscalid) B9, bipyrazam (bispyrifam) B10, flufenamide (flufenamid) B11, fluflufenamid (flufenapyr) B12, thiazamide (thifluzamide) B13, flufenamid (fluflufenamid) B14, flufenamid (flufenamid) B15, flufenamid (flufenamid) B16, flufenamid (flufenamid) B18, flufenamid (flufenamid) B18, flufenamid B17 pyrapoyne B21, benazolin (benazolin) B26, fluoxastrobin (fluoxastrobin) B27, fenamidone (fenamidone) B28, famoxadone (famoxadone) B29, cyazofamid (cyazofamid) B30, zoxamide (ametocadin) B31, fluazinam (fluazinam) B32, fenpicoxamid B33, florylpicoxamid B, indazole sulfenamide (amisulben) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, flumorph (fluminoph) B41, dimethomorph (dimethomorph) B42, mandipropamid (dipalmidamid) B43, zoxamide) B44, mefloxuridine (metaxamide) B46, fluanil-M46, fluanil (fluanid) B47, benzofenamide (cyanide) B51, fluanide (myclobutanil) B51, flufenamid (pyrithiofuran) B, thiazole bacteria amine (ethaboxam) B52, bupirimate B56, dimethirimol B57, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, xin Saitong (octyilone) B60, furamide (oface) B61, quinolone (carbomethoxy) B62, fludioxonil (fluxoil) B65, fenpiclonil (fenpiclonil) B66, iprodione (iprodione) B67, procymidone (procymidone) B68, dimethachlon (dimethachlon) B71, dimethachlon (vinazozol) B72, diethofencarb (dimethachranine) B73, benzophenone (methenone) B74, pyrifenone B75, polythiazol (carbomethoxy) B76, methimazole B77, pyribenzoxazol (methyl) B78, pyribenzoxazol B85; chlorpyrimol B86, fenbuconazole B87, fenpropidin B88, fenpropidone B90, penflufen B91, nuarimol B92, oxamidazole B93, pyrifos-ethyl B94, prochloraz B95, spiroxamine B96, pyrisoxazole B97, simeconazole B104, ipfentrifluconazole B, diphenoxazole B111, iprogram B114, pyripyropene B115, fluorothiazolethide B84, pyrithione B116, pyrithione B118, pyrithione B116, pyrithione B117, pyrithione B116, pyrithione B118, pyrithione B117, pentachloronitrobenzene (quintozene) B121, tolclofos (tolclofos-methyl) B122, benthiavalicarb-isopropyl) B123, polyoxin (polyoxin) B124, valicarb (valicalate) B125, pyrimorph (pyrimorph) B126, cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, cyprodinil (mepanipyrim) B130, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycin) B132, zineb (zineb) B134, mancozeb) B135, metiram (metiram) B136, propineb (propineb) B137, maneb (maneb) B138, mancozeb (pyribam) B, propineb (pyribam) B142, copper (pyribam) B145, copper (pyribam) B dichlormid (anilazine) B146, captan (captan) B147, chlorothalonil (chlorothalonil) B149, benfomesafen (dichlorfluanid) B150, tolofloxacin (tolyfluanid) B151, thiodicarb (methiocarb) B154, captan (captafol) B155, folpet (folpet) B156, thiazolium (zinc) B159, quinolinium (oxine-coppers) B160, thiothidiazuron (thiodicazole-coppers) B161, nonoxycopper (cuppric nonyl phenolsulfonate) B162, picarbazone B163, amipyrin B164, metyltetraprole B, pyridachlometyl B, validamycin (validamin) B, azozone (hydrazone) B170, buflozon B171, quinifluanin B173, quintoxazone B174, or one of quintoxaprop B176.
Still further preferably, the composition is an active component A and an active component B in a weight ratio of 1:10 to 10:1;
wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C 1 -C 4 An alkyl group; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r is R 4 、R 5 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 6 、R 7 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 8 、R 9 May be the same or different and are each selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from benzovindesilopyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyram B5, fluopyram B6, flubendiamide (sedaxane) B7, penthiopyrad B8, boscalid B9, flubendiamide B5, flubendiamide B6, flubendiamide (sedaxane) and flubendiamide B Biflupyraclostrobin B10, thifluzamide B13, fluxapyroxad hydroxylamine (pydifumetofen) B14, fludanazol amide (flupindapyr) B15, fluoroether amide (fluopimide) B16, innorfluxam B18, isoflupram B19, pyraflumid B20, pyraflumone B21, mefenoxam (benomyl) B26, fluopyram (fluopimide) B27, fenamidone (fenamidone) B28 famoxadone B29, cyazofamid B30, ametoctradin B31, fluazinam B32, fenpiclamide B33, florylpicoxamid B34, silthiopham B36, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, iprovalicarb B47, cymoxanil B48, thiabendazole B51, thiazoloxapyrim B52, bupirimate B56, bupirimate B58, methimazole B62, methimazole B60, fludioxonil B30, fludioxonil B46, fluvalalim B47, fludioxonil B48, thiabendazole B51, ethaboxam B52, bupirimate B56, bupirimate B58, methimazole B60, fludioxonil B60 Iprodione (iprodione) B67, procymidone (procymidone) B68, diethofencarb (diethofencarb) B73, metrafenone (metrafenone) B74, pyrifenone B75, carbendazim (carboxin) B76, thiophanate-methyl) B77, myclobutanil (phenamacril) B78, fenbuconazole (fenbuconazole) B87, penfluconazole (mefenozole) B91, fluorobenzol (nuarimol) B92, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyrimazole (pyrimazole) B97, simeconazole (simeconazole) B104, 35106, ipfipronil (ipfos) B114, pyrimoxazole (pyrimoxazole) B116, pyrimoxazole (prochloraz) B115, pyrifenozole) B116, pyrifluazinam (pyrimoxazole) B117; pentachloronitrobenzene (quintozene) B121, tolclofos (tolclofos-methyl) B122, benthiavalicarb-isopropyl) B123, polyoxin (polyoxin) B124, valicarb (valicalate) B125, pyrimorph (pyrimorph) B126, cyprodinil (cyprodinil) B128, kasugamycin (kasugamycin) B129, pyrimethanil (pyrimethanil) B131, streptomycin (streptomycmycins) B132, zineb (zineb) B134, mancozeb (mancozeb) B135, metiram (metiram) B136, propineb (procyanib) B137, sulfopyrim (sulfoprint) B145, captan (captan) B147, chlorothalonil (cyprodinil) B, benzoglide (149), benzoglide (thioflavin) B150, thiozin (thioflavin) B159, thiozin (thiozineb) B159, thiozineb (thiozineb) B159), one or more of quinoline copper (oxamine-connector) B160, thiobacillus copper (thiobacillus-connector) B161, nonomycete copper (cuppric nonyl phenolsulfonate) B162, picarbazox B163, aminopyrafen B164, metyltetraprole B165, pyridachlometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipymetrizole B175, and teclofthalam B176.
Application of bactericidal composition in preparing medicine for preventing and treating plant pathogenic fungi and bacterial diseases
The plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, leaf mold, banded sclerotial blight, damping off, black nevus, smut, black powder disease, downy mildew, late blight, epidemic disease, downy mildew, black shank, cotton rot, damping off, cotton rot, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, gummy stem blight, gray mold, sclerotium disease, rot, root rot, scab, soft rot, white leaf blight, angular leaf spot, round spot, bacterial leaf blight, bacterial wilt, ulcer or yellow dragon.
The bactericidal preparation comprises the active ingredients of the bactericidal composition, wherein the bactericidal composition accounts for 0.1-95% by weight.
The composition of the present invention is used at a concentration of 5 to 500mg/L (active ingredient content, the same applies hereinafter) in the crop planting area, preferably 50 to 200mg/L, depending on the occurrence degree of crop diseases.
The composition of the invention comprises an active component A and at least one active component B which are prepared in advance or prepared on the site of use according to the proper proportion provided by the invention or the two components are used separately and sequentially.
The composition of the invention is suitable for the application of trees (apples, rubber, pears, oranges, haws, chinese chestnut, peppers, medlar, mangoes, papaya, litchis, bananas, peach trees and the like), vines (grapes and the like), melons and vegetables (tomatoes, eggplants, peppers, cucumbers, melons, white melons, watermelons, pumpkins, balsam pears, luffa, chayote, cucurbits, lettuce, potatoes, carrots), beans (peas, beans, cowpeas), cereals (wheat, rice, corn, sorghum and the like), oil crops (oilseed rape, soybeans, peanuts, sesame and the like), allium fistulosum (onions, garlic, onions), cash crops (tobacco and the like), fungi and bacterial diseases of flowers and lawns, seed treatment, fruit preservation and the like.
The bactericidal composition is particularly suitable for preventing and curing the following plant diseases: chayote powdery mildew, cucurbit powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew powdery mildew of wheat, powdery mildew of barley, powdery mildew of rose, powdery mildew of chrysanthemum chayote powdery mildew, cucurbit powdery mildew, pumpkin powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew, wheat powdery mildew, barley powdery mildew, rose powdery mildew, chrysanthemum powdery mildew powdery mildew of turf grass, powdery mildew of carrot, rust of apple tree, rust of pear tree, rust of soybean, rust of pea, rust of bean, rust of cowpea, rust of wheat, rust of barley, rust of corn onion rust, garlic rust, onion rust, turf grass rust, apple tree anthracnose, rubber tree anthracnose, pear tree anthracnose, citrus anthracnose, hawthorn anthracnose, chestnut anthracnose, prickly ash anthracnose, medlar anthracnose, mango anthracnose, papaya anthracnose, hazelnut anthracnose, grape anthracnose, tomato anthracnose, eggplant anthracnose, pepper anthracnose, melon anthracnose, white gourd anthracnose, watermelon anthracnose, pumpkin anthracnose, balsam pear anthracnose, luffa anthracnose, chayote anthracnose, cucurbit anthracnose, pumpkin anthracnose, lettuce anthracnose, cucumber downy mildew, grape downy mildew, melon downy mildew, balsam pear downy mildew, luffa downy mildew, tomato late blight, potato late, pepper blight, cucumber damping off, eggplant damping off, pepper damping off, pear tree brown spot, cucumber brown spot, pear black spot, china rose black spot, chrysanthemum black spot, soybean brown spot, cowpea red spot, apple alternaria leaf spot, bean round spot, eggplant leaf spot, potato black nevus, wheat sheath blight, rice bakanae disease, soybean damping-off, pea damping-off, bean damping-off, onion damping-off, garlic damping-off, onion damping-off, turf grass damping-off, citrus canker, citrus yellow dragon, rice bacterial leaf blight, rice bacterial leaf spot, tomato bacterial wilt, cucumber bacterial angular leaf spot, crop gray mold caused by botrytis and sclerotium pathogenic bacteria, sclerotium disease and the like.
The invention has the advantages that:
the invention combines the active component A and the active component B of the bactericide according to different proportions, the observation efficacy is larger than the calculation efficacy, the synergistic effect is obvious, the dosage of the medicament can be reduced, and the environmental pollution is reduced. The invention selects the bactericides with different action mechanisms to mix, is favorable for delaying the generation of drug resistance of pathogenic bacteria, provides an effective solution to the problem of the resistance of bactericides in agricultural production and pesticide industry, and prolongs the service life of the medicament.
Detailed Description
The synergistic effect of the compositions of the present invention on harmful fungi, bacterial diseases is further illustrated by the following examples, but the invention is in no way limited thereto. Wherein the active components are the compound A and the bactericide B in the bactericidal composition;
the preparation of the compound A is described in WO2016184378, and the bactericide B is one or more selected from respiratory inhibitor bactericides, nucleic acid metabolism inhibitor bactericides, cell wall synthesis inhibitor bactericides, signal transduction inhibitor bactericides, cytoskeletal and kinesin inhibitor bactericides, sterol biosynthesis inhibitor bactericides, phospholipid synthesis inhibitor bactericides, cell wall synthesis inhibitor bactericides, methionine biosynthesis inhibitor bactericides, multi-site inhibitor bactericides and bactericides with unknown action mechanism.
The test method and the evaluation method are as follows:
the active samples to be tested are respectively an active component A, an active component B, and a composition of the active component A and the active component B.
The active component A is one or more of an active component A1, an active component A2, an active component A3 and an active component A4;
wherein the active component A1 is a compound A1 shown in a general formula I-A;
the active component A2 is a salt formed by a compound A1 and sulfuric acid;
compound A1 is
Wherein R is 3 Selected from hydrogen, R 4 、R 5 Respectively selected from hydrogen, R 6 、R 7 Respectively selected from hydrogen, R 8 、R 9 Respectively selected from hydrogen, R 11 Selected from 4-chloro, n=1, r 14 、R 15 、R 16 Or R is 17 Respectively selected from hydrogen, wherein W is selected from hydrogen, namely the compound A1;
the active component A3 is a compound A3 shown in the general formula I-B;
the active component A4 is a salt formed by a compound A3 and sulfuric acid:
compound A3 is
Wherein:
R 1 selected from difluoromethyl, R 2 Selected from chlorine, R 3 Selected from hydrogen, R 4 、R 5 Respectively selected from hydrogen, R 6 、R 7 Respectively selected from hydrogen, R 8 、R 9 Respectively selected from hydrogen, R 11 Is selected from 4-chlorine, and W is selected from hydrogen, namely the compound A3.
The active components B are benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad hydroxylamine B14, fluopicolide B27, zoxamide B31, fluazinam B32, fenpropiram B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, bupirimate B56, bupirimate B58, fludioxonil B65, diethofencarb B73, metrafenone B74, fenhexamid B78, penoxsulam B91, prochloraz B95, fluzoxamide B116, fluoxapiproline B, polyoxin B124, kasugamycin B129, zineb 134, mancozeb 135, mancozeb 136, propineb B137, captan B147, chlorothalonil B149, thiamethoxam B163, pyribenzoxim B165, propineb B25, and metyltetraprole B.
The composition to be tested is an active component A1, each active component B, the active component A1 and each active component B respectively; the active components B are compositions of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad hydroxylamine B14, fluopicolide B27, zoxamide B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, bupirimate B56, bupirimate B58, fludioxonil B65, diethofencarb B73, metrafenone B74, fenhexamid B78, penoxsulam B91, prochloraz B95, oxaziram B116, fluoxapiproline B, polyoxin B124, kasugamycin B129, zineb 134, mancozeb 135, metiram B136, propineb B137, captan B147, chlorothalonil B149, copper-pyrim B163, copper-pyrimid B159, pyrimid B165, pyrimid B164.
The composition to be tested is composed of active components A2 and/or compositions of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad hydroxylamine B14, fluopicolide B27, flumetsulam B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, bupirimate B56, bupirimate B58, fludioxonil B65, diethofencarb B73, metrafenone B74, fenpyraclostrobin B78, difenoconazole B91, prochloraz B95, fluoxazinone B116, fluoxapiproline B, polyoxin B124, rapamycin B129, zineb zinc 134, mancozeb 135, metiram B136, propineb B137, captan B147, zineb 149, copper pyrim B159, propineb B165, and metyltetraprole B.
The composition to be tested is composed of active components A3 and/or compositions of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad hydroxylamine B14, fluopicolide B27, flumetsulam B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, bupirimate B56, bupirimate B58, fludioxonil B65, diethofencarb B73, metrafenone B74, fenpyraclostrobin B78, difenoconazole B91, prochloraz B95, fluoxazinone B116, fluoxapiproline B, polyoxin B124, rapamycin B129, zineb zinc 134, mancozeb 135, metiram B136, propineb B137, captan B147, zineb B149, copper-37B 165, propineb B165, 37 and 37-n-164.
The composition to be tested is composed of active components A4 and/or compositions of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad hydroxylamine B14, fluopicolide B27, flumetsulam B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B46, bupirimate B56, bupirimate B58, fludioxonil B65, diethofencarb B73, metrafenone B74, fenpyraclostrobin B78, difenoconazole B91, prochloraz B95, fluoxazinone B116, fluoxapiproline B, polyoxin B124, rapamycin B129, zineb zinc 134, mancozeb 135, metiram B136, propineb B137, captan B147, zineb B149, copper-37B 165, propineb B165, 37 and 37-n-164.
The specific mode is as follows:
the active components or the composition are dissolved by acetone (the volume ratio of the acetone amount to the spray liquid amount is equal to or smaller than 0.05), diluted by water containing 0.1% Tween 80 to prepare a solution to be tested with the required concentration, and the solution to be tested of the composition is prepared according to the set proportion. The liquid to be tested is sprayed on neat and consistent host plants (not inoculated before application and other medicines) cultured in a greenhouse on a crop sprayer, and disease inoculation is carried out after 24 hours. According to the disease characteristics, inoculating a disease plant to be subjected to temperature control and moisture preservation culture, then placing the inoculated plant into a climatic chamber for culture, and transferring the plant into a greenhouse for culture after the disease is infected; the disease plants which do not need to be subjected to the moisture preservation culture are inoculated and then directly transferred into a greenhouse for culture. And after the disease is sufficiently developed by contrast, carrying out disease investigation, and recording the total leaf number, the disease leaf number and the disease progression of the investigation.
The disease classification method comprises the following steps:
level 0: the whole plant is free from diseases;
stage 1: spot area is less than 5% of the whole leaf area;
3 stages: spot area spot 6-10% of the whole leaf area;
5 stages: spot area spot 11-20% of the whole leaf area;
7 stages: spot area spot 21-50% of the whole leaf area;
stage 9: the area of the lesion is more than 51% of the whole leaf area.
Observed efficacy of active Components or compositions (C obs ) The pesticide effect evaluation general formula (correction control effect calculation formula) is used for calculation:
efficacy of "0" means that the level of infestation of the treated crop is the same as the level of infestation of the untreated control crop; efficacy of "100" means that the treated crop was not infested.
Expected efficacy of the composition (C exp ) The use of Abbott method (see Liu Xuemin et al, synergistic effect of bactericide blend, pesticide science and management, 2002, 23 (5), 12-15).
C exp ＝X+Y–XY/100
Wherein:
x: efficacy of active component a at a concentration of a;
y: efficacy of active component B at concentration B is used.
The synergistic effect of the composition was observed with respect to efficacy (C obs ) And expected efficacy (C) exp ) Is a ratio of (2). When the ratio (synergistic ratio)>1, the composition shows a synergistic effect; when the ratio (synergistic ratio) =1, the composition exhibits an additive effect; when the ratio (synergistic ratio)<1, the composition is antagonistic.
Example 1 test 1 for controlling powdery mildew of cucumber
The seedlings of the potted two-leaf stage cucumber of the variety Jinyan-4 are sprayed with an aqueous solution of each active component or composition (the concentration of the active components is shown in the table below), after 24 hours, the spores of the powdery mildew are sprayed on leaves by a connector, and are cultured in a greenhouse, and after 10 days, the disease is investigated after the contrast is fully distributed.
The activity data and the synergistic effect of each individual active component and the composition for preventing and treating powdery mildew of cucumber are shown in tables 1 and 2.
The results in Table 2 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on powdery mildew of cucumber in the range of the experimental proportion.
TABLE 1 Activity of the individual active ingredients
TABLE 2 Activity and synergy of the compositions of the invention
Example 2 test 2 for controlling powdery mildew of cucumber
The seedlings of the potted two-leaf stage cucumber with the variety of 'Xintaimi thorns' are sprayed with an aqueous solution of each active component or composition (the concentration of the active components is shown in the table below), after 24 hours, the spores of the yellow white powder germ are sprayed on the leaves by a connector, and are cultured in a greenhouse, and after 10 days, the disease is investigated after the contrast is fully distributed.
The activity data and the synergistic effect of each individual active component and the composition for preventing and treating powdery mildew of cucumber are shown in tables 3 and 4.
The results in Table 4 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on powdery mildew of cucumber in the range of the experimental proportion.
TABLE 3 Activity of the individual active ingredients
TABLE 4 Activity and synergistic effects of the compositions of the present invention
EXAMPLE 3 test for controlling powdery mildew of melon
Potted four-leaf stage melon seedlings (1-2 leaves have been cut off before the test, and only 3-4 leaves remain) of the variety "Hongxian melon" are sprayed with an aqueous solution of each active component or composition (the concentrations are described in the following table), after 24 hours, melon powdery mildew spore suspensions are inoculated on the leaves, and cultured in a greenhouse, and after 15 days, disease investigation is performed after sufficient disease is achieved by contrast.
The activity data of each independent active component for preventing and treating melon powdery mildew are shown in table 5.
The activity data and the synergistic effect of the composition for preventing and treating melon powdery mildew are shown in Table 6.
The results in Table 6 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on melon powdery mildew in the range of the experimental proportion.
TABLE 5 Activity of the individual active ingredients
TABLE 6 Activity and synergistic effects of the compositions of the present invention
Example 4 test for controlling powdery mildew of Capsici fructus
Spraying the potted six-leaf stage pepper seedling of green round pepper with water solution of each active component or composition (the concentration of the active components is shown in the following table), inoculating the pepper powdery mildew spores on the back of the leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the disease is infected, and carrying out disease investigation after the contrast is fully distributed after 20-25 days.
The activity data of each single active component for preventing and treating pepper powdery mildew are shown in tables 7 and 8.
The activity data and the synergistic effect of the composition for preventing and treating powdery mildew of capsicum are shown in Table 9 and Table 10.
The results in tables 9 and 10 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on powdery mildew of capsicum in the experimental proportioning range.
TABLE 7 Activity of the individual active ingredients
TABLE 8 Activity of the individual active ingredients
TABLE 9 Activity and synergy of the compositions of the present invention
TABLE 10 Activity and synergy of the compositions of the present invention
Example 5 test for controlling powdery mildew of beans
Spraying young plants of potted two-leaf stage kidney bean of variety "Fengshou No. 1" with aqueous solutions of each active component or composition (the concentrations of the active components are shown in the following table), naturally drying after spraying, and after 24 hours, suspending the pathogenic bacteria spores of kidney bean powdery mildew in water (5×10) 6 Seed on kidney bean leaves, naturally air-dried, transferred into a greenhouse for cultivation, and the cultivation conditions (temperature: day 23-28deg.C, night 18-20deg.C) and investigation of the disease condition after the control is sufficiently ill.
The activity data of each individual active component for preventing and treating powdery mildew of kidney beans are shown in Table 11.
The activity data and the synergistic effect of the composition for preventing and treating powdery mildew of kidney beans are shown in Table 12.
The results in Table 12 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on powdery mildew of kidney beans in the range of the experimental proportioning.
TABLE 11 Activity of the individual active ingredients
TABLE 12 Activity and synergy of the compositions of the present invention
Example 6 test for controlling powdery mildew of tobacco
The potted six-leaf tobacco seedling with the variety CN89 is sprayed with the water solution of each active component or composition, the concentration is shown in the following table, and after 24 hr, tobacco powdery mildew spore suspension is inoculated onto tobacco seedling leaf, and the tobacco seedling is directly transferred into greenhouse for cultivation, and after 20 days, the disease is investigated after the contrast is fully distributed.
The activity data of each individual active component for preventing and treating tobacco powdery mildew are shown in Table 13.
The activity data and the synergistic effect of the composition for preventing and treating tobacco powdery mildew are shown in Table 14.
The results in Table 14 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on tobacco powdery mildew in the range of a test proportion.
TABLE 13 Activity of individual active Components
TABLE 14 Activity and synergy of the compositions of the present invention
Example 7 test for controlling corn rust
The two-leaf stage potted corn seedlings with the variety 'golden glutinous' are sprayed with water solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, corn rust germ spore suspension is inoculated on corn leaves and cultured in a climatic chamber, after disease infection is completed, the corn seedlings are transferred into a greenhouse for culture, and after 7 days, disease investigation is carried out after full contrast is carried out.
The activity data of each individual active ingredient of the present invention for controlling corn rust is shown in table 15.
The activity data and synergy of the compositions of the present invention for controlling corn rust are shown in Table 16.
The following table16 shows the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on corn rust in the range of the test proportion.
TABLE 15 Activity of individual active Components
TABLE 16 Activity and synergy of the compositions of the present invention
Example 8 test 1 for controlling cucumber downy mildew
The cucumber seedlings in the two-leaf stage of the pot plant with the variety of 'Xintaimi thorns' are subjected to spray treatment by using an aqueous solution of each active component or composition (the concentration of the active components is shown in the table below), after 24 hours, the cucumber downy mildew pathogenic bacteria sporangium suspension is inoculated on cucumber leaves and cultured in a climatic chamber, after the infection of diseases is completed, the cucumber seedlings are transferred into a greenhouse for culture, and after the contrast is sufficiently developed, the disease condition is investigated.
The activity data of each individual active component for controlling cucumber downy mildew are shown in Table 17.
The activity data and the synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 18.
The results in Table 18 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber downy mildew over the range of the tested ratios.
TABLE 17 Activity of individual active Components
TABLE 18 Activity and synergy of the compositions of the present invention
Example 9 test 2 against cucumber downy mildew
The cucumber seedlings in the two-leaf stage of the pot plant with the variety of 'Xintaimi thorns' are subjected to spray treatment by using an aqueous solution of each active component or composition (the concentration of the active components is shown in the table below), after 24 hours, the cucumber downy mildew pathogenic bacteria sporangium suspension is inoculated on cucumber leaves and cultured in a climatic chamber, after the infection of diseases is completed, the cucumber seedlings are transferred into a greenhouse for culture, and after the contrast is sufficiently developed, the disease condition is investigated.
The activity data of each individual active ingredient of the invention for controlling cucumber downy mildew are shown in Table 19.
The activity data and the synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 20.
The results in Table 20 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber downy mildew over the range of the tested ratios.
TABLE 19 Activity of individual active Components
TABLE 20 Activity and synergy of the compositions of the present invention
Example 10 test 3 against cucumber downy mildew
The test is carried out according to the national standard GB/T17980.26-2000: pesticide field efficacy test criterion (one) -related content execution of the bactericide for preventing and controlling cucumber downy mildew. The cucumber is experimentally set in the eight town protection place in Sujia Tu area of Shenyang, the cucumber variety is Xintaimi thorn, in the management level, when the test is carried out, the cucumber is in the melon setting period, the downy mildew is slightly generated, and the area of the district is about 25m 2 The method comprises the steps of carrying out a first treatment on the surface of the Spraying the cucumber with the medicament according to the set dose of the test; the test was carried out 2 times with 7 days between the two administrations, and 10 days after the second administration, and the occurrence of cucumber downy mildew in each cell was investigated. 4-point sampling is carried out in each cell, 8 plants are taken in each point, and the disease condition of all the plants is investigated from top to bottom.
The activity data of each individual active component for preventing and treating cucumber downy mildew are shown in Table 21.
The activity data and the synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 22.
The results in Table 22 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber downy mildew over the range of the tested ratios.
TABLE 21 Activity of the individual active ingredients
TABLE 22 Activity and synergy of the compositions of the present invention
Example 11 test 4 against cucumber downy mildew
The cucumber seedlings in the two-leaf stage of the pot plant with the variety of 'Xintaimi thorns' are subjected to spray treatment by using an aqueous solution of each active component or composition (the concentration of the active components is shown in the table below), after 24 hours, the cucumber downy mildew pathogenic bacteria sporangium suspension is inoculated on cucumber leaves and cultured in a climatic chamber, after the infection of diseases is completed, the cucumber seedlings are transferred into a greenhouse for culture, and after the contrast is sufficiently developed, the disease condition is investigated.
The activity data of each individual active component for controlling cucumber downy mildew are shown in Table 23.
The activity data and the synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 24.
The results in Table 24 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber downy mildew over the range of the tested ratios.
TABLE 23 Activity of individual active Components
TABLE 24 Activity and synergy of the compositions of the present invention
Example 12 test 1 for controlling grape downy mildew
The potted pentaleaf stage grape seedlings with the variety of 'seedless Bai Jixin' are sprayed with aqueous solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of diseases is completed, the grape seedlings are transferred into a greenhouse for culture, and after the contrast is fully developed, the disease condition is investigated after 7 days.
The activity data for controlling grape downy mildew for each individual active ingredient of the present invention is shown in Table 25.
The activity data and the synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 26.
The results in Table 26 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on grape downy mildew over the range of the tested ratios.
TABLE 25 Activity of individual active Components
TABLE 26 Activity and synergy of the compositions of the present invention
Example 13 test 2 against grape downy mildew
The potted pentaleaf stage grape seedlings with the variety of 'seedless Bai Jixin' are sprayed with aqueous solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of diseases is completed, the grape seedlings are transferred into a greenhouse for culture, and after the contrast is fully developed, the disease condition is investigated after 7 days.
The activity data of each individual active ingredient of the invention for controlling grape downy mildew are shown in Table 27.
The activity data and the synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 28.
The results in Table 28 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on grape downy mildew over the range of the tested ratios.
TABLE 27 Activity of individual active Components
TABLE 28 Activity and synergy of the compositions of the present invention
Example 14 test 3 against grape downy mildew
The potted pentaleaf stage grape seedlings with the variety of 'seedless Bai Jixin' are sprayed with aqueous solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of diseases is completed, the grape seedlings are transferred into a greenhouse for culture, and after the contrast is fully developed, the disease condition is investigated after 7 days.
The activity data of each individual active ingredient of the invention for controlling grape downy mildew are shown in Table 29.
The activity data and the synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 30.
The results in Table 30 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on grape downy mildew over the range of the tested ratios.
TABLE 29 Activity of individual active Components
TABLE 30 Activity and synergy of the compositions of the present invention
Example 15 test 4 against grape downy mildew
The potted pentaleaf stage grape seedlings with the variety of 'seedless Bai Jixin' are sprayed with aqueous solutions of active components or compositions (the concentration of the active components is shown in the table below), after 24 hours, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of diseases is completed, the grape seedlings are transferred into a greenhouse for culture, and after the contrast is fully developed, the disease condition is investigated after 7 days.
The activity data of each individual active ingredient of the invention for controlling grape downy mildew are shown in Table 31.
The activity data and the synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 32.
The results in Table 32 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on grape downy mildew over the range of the tested ratios.
TABLE 31 Activity of individual active Components
TABLE 32 Activity and synergy of the compositions of the present invention
EXAMPLE 16 test for controlling downy mildew of cabbage
Spraying the potted five-leaf stage Chinese cabbage seedling of the variety 'four-season Chinese cabbage' with water solution of each active component or composition (the concentration of the active components is shown in the following table), inoculating the Chinese cabbage downy mildew spore ascope on the back of the leaf for 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the contrast is fully developed after 5-7 days.
The activity data of each independent active component for preventing and treating cabbage downy mildew are shown in Table 33.
The activity data and the synergistic effect of the composition for preventing and treating cabbage downy mildew are shown in Table 34.
The results in Table 34 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on cabbage downy mildew in a test proportion range.
TABLE 33 Activity of individual active Components
TABLE 34 Activity and synergy of the compositions of the present invention
EXAMPLE 17 test for controlling sunflower downy mildew
Potted six-leaf stage sunflower seedlings (1-4 leaves have been cut off before the test and only 5-6 leaves remain) of the variety 'three eyebrows' are sprayed with an aqueous solution of each active component or composition (the concentration of the active components is as described in the following table), after 24 hours, the sunflower downy mildew germ sporangium suspension is inoculated on the leaves and cultivated in a climatic chamber, after the infection of the disease is completed, the sunflower seedlings are transplanted into a greenhouse for cultivation, and after 12 days, the disease investigation is carried out after the contrast is fully distributed.
The activity data of each individual active ingredient of the invention for controlling sunflower downy mildew are shown in Table 35.
The activity data and the synergistic effect of the composition for preventing and treating sunflower downy mildew are shown in Table 36.
The results in Table 36 below show that observations of the compositionsEfficacy (C) obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on sunflower downy mildew in the experimental proportioning range.
TABLE 35 Activity of individual active Components
TABLE 36 Activity and synergy of the compositions of the present invention
Example 18 tomato late blight control test 1
The potted pentaleaf stage tomato seedling with the variety "Pintai " is sprayed with an aqueous solution of each active component or composition (the concentration of the active components is shown in the following table), after 24 hours, the tomato late blight pathogenic bacteria sporangium suspension is inoculated on tomato leaves, the tomato seedling is placed in a climatic chamber for culture, after the infection of diseases is completed, the tomato seedling is transferred into a greenhouse for culture, and after the contrast is fully developed, the disease investigation is carried out after 7 days.
The activity data of each individual active ingredient of the present invention for controlling tomato late blight is shown in table 37.
The activity data and synergy of the compositions of the invention for controlling tomato late blight are shown in Table 38.
The results in Table 38 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on tomato late blight disease over the range of the tested formulation.
TABLE 37 Activity of individual active Components
TABLE 38 Activity and synergy of the compositions of the present invention
Example 19 tomato late blight control test 2
The potted pentaleaf stage tomato seedling with the variety "Pintai " is sprayed with an aqueous solution of each active component or composition (the concentration of the active components is shown in the following table), after 24 hours, the tomato late blight pathogenic bacteria sporangium suspension is inoculated on tomato leaves, the tomato seedling is placed in a climatic chamber for culture, after the infection of diseases is completed, the tomato seedling is transferred into a greenhouse for culture, and after the contrast is fully developed, the disease investigation is carried out after 7 days.
The activity data of each individual active ingredient of the present invention for controlling tomato late blight is shown in Table 39.
The activity data and synergy of the compositions of the invention for controlling tomato late blight are shown in Table 40.
The results in Table 40 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on tomato late blight disease over the range of the tested formulation.
TABLE 39 Activity of individual active Components
TABLE 40 Activity and synergy of the compositions of the present invention
Example 20 test 1 for controlling cucumber anthracnose
Spraying the potted two-leaf period cucumber seedlings with the variety of 'Xintaimi thorns' with water solutions of active components or compositions, naturally airing the seedlings after spraying, inoculating a cucumber anthracnose pathogen spore water suspension on cucumber leaves after 24 hours, culturing the seedlings in a climatic chamber, transferring the seedlings into a greenhouse for culturing after the diseases are infected, carrying out disease investigation after 7 days, grading the leaves according to the development degree of pathogen infection on the leaves, recording the total leaf number, the leaf number and the disease number of the investigation, and calculating the medicament efficacy according to a formula.
The activity data of each individual active component of the invention for controlling cucumber anthracnose are shown in Table 41.
The activity data and the synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 42.
The results in Table 42 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose over the range of the tested formulation.
TABLE 41 Activity of individual active Components
TABLE 42 Activity and synergy of the compositions of the present invention
Example 21 test 2 for controlling cucumber anthracnose
Spraying the potted two-leaf period cucumber seedlings with the variety of 'Xintaimi thorns' with water solutions of active components or compositions, naturally airing the seedlings after spraying, inoculating a cucumber anthracnose pathogen spore water suspension on cucumber leaves after 24 hours, culturing the seedlings in a climatic chamber, transferring the seedlings into a greenhouse for culturing after the diseases are infected, carrying out disease investigation after 7 days, grading the leaves according to the development degree of pathogen infection on the leaves, recording the total leaf number, the leaf number and the disease number of the investigation, and calculating the medicament efficacy according to a formula.
The activity data of each individual active component for controlling cucumber anthracnose are shown in Table 43.
The activity data and the synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 44.
The results in Table 44 below show that the compositions have a ratio of observed efficacy (Cobs) to expected efficacy (Cexp) of greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose over the range of the tested formulation.
TABLE 43 Activity of individual active components
TABLE 44 Activity and synergy of the compositions of the present invention
EXAMPLE 22 test for controlling Capsici fructus anthracnose
Spraying the potted six-leaf stage pepper seedling with green round pepper for 24 hr, inoculating the pepper anthracnose spore suspension onto the back of the leaf blade, culturing in climatic chamber, culturing in greenhouse for 5-7 days, and inspecting the disease condition.
The activity data of each individual active component for preventing and treating pepper anthracnose is shown in Table 45.
The activity data and the synergistic effect of the composition for preventing and treating pepper anthracnose are shown in Table 46.
The results in Table 46 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on pepper anthracnose in the experimental proportioning range.
TABLE 45 Activity of individual active components
TABLE 46 Activity and synergy of the compositions of the present invention
Example 23 test for controlling eggplant brown spot
The potted eggplant seedlings in five-leaf period with the variety Liaoeggplant No. 1 are sprayed with the water solution of each active component or composition (the concentration is shown in the table below), after 24 hours, eggplant brown spot germ spore suspension is inoculated on eggplant leaves and cultured in a climatic chamber, after the infection of diseases is completed, the eggplant seedlings are transferred into a greenhouse for culture, and after the control is fully distributed for disease, the disease condition is investigated after 10 days.
The data of the activity of each individual active component for preventing and treating eggplant brown spot are shown in Table 47.
The activity data and the synergistic effect of the composition for preventing and treating eggplant brown spot are shown in Table 48.
The results in Table 48 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on eggplant brown spot in a test proportion range.
TABLE 47 Activity of individual active Components
TABLE 48 Activity and synergy of the compositions of the present invention
Example 24 test for controlling leaf spot disease in Isaria verniciflua
Potted eggplant seedlings of the Liaoqian No. 1 in five-leaf period are sprayed with water solutions of active components or compositions (the concentration is shown in the table below), after 24 hours, the eggplant leaf spot bacterial spore suspension is inoculated on eggplant leaves and cultured in a climatic chamber, after the infection of diseases is completed, the eggplant seedlings are transferred into a greenhouse for culture, and after 8 days, the disease investigation is carried out after the contrast is fully distributed.
The activity data of each individual active component for preventing and treating the leaf spot disease of the eggplant is shown in Table 49.
The activity data and the synergistic effect of the composition for preventing and treating the leaf spot disease of the eggplant are shown in Table 50.
The results in Table 50 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on the leaf spot of the eggplant in the test proportioning range.
TABLE 49 Activity of individual active Components
TABLE 50 Activity and synergy of the compositions of the present invention
EXAMPLE 25 test for controlling pear black spot
Potted plant Miao Nenshe with pear variety is taken, and after surface disinfection, the potted plant is washed clean with sterile water and dried in shade for standby. Soaking with aqueous solution of each active component or composition (concentration is shown in the following table), inoculating spore suspension of Pyricularia pyrifolia onto leaf for 24 hr, placing into culture dish (containing 2% water agar) for constant temperature illumination culture, and performing disease investigation after control is fully affected after 14 days.
The data of the activity of each individual active ingredient for preventing and treating pear black spot is shown in Table 51.
The activity data and the synergistic effect of the composition for preventing and treating pear black spot are shown in Table 52.
The results in Table 52 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on pear black spot in the range of the test proportion.
TABLE 51 Activity of individual active Components
TABLE 52 Activity and synergy of the compositions of the present invention
Example 26 test 1 for controlling peanut leaf spot
Two pairs of pot-cultivated double-leaf flat-period peanut seedlings with a variety of white sand are sprayed with aqueous solutions of active components or compositions (the concentrations are shown in the table below), after 24 hours, brown fungus spore suspension of peanut is inoculated on leaves and cultured in a climatic chamber, after disease infection is completed, the pot-cultivated plants are moved into a greenhouse for culture, and after control is complete, disease investigation is carried out after 10-12 days.
The activity data of each individual active component for preventing and treating peanut leaf spot disease are shown in table 53.
The activity data and the synergistic effect of the composition for preventing and treating the leaf spot disease of the peanut are shown in table 54.
The results in Table 54 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on peanut leaf spot in the range of the test proportion.
TABLE 53 Activity of individual active Components
TABLE 54 Activity and synergy of the compositions of the present invention
Example 27 test 2 against peanut leaf spot
Two pairs of pot-cultivated double-leaf flat-period peanut seedlings with a variety of white sand are sprayed with aqueous solutions of active components or compositions (the concentrations are shown in the table below), after 24 hours, brown fungus spore suspension of peanut is inoculated on leaves and cultured in a climatic chamber, after disease infection is completed, the pot-cultivated plants are moved into a greenhouse for culture, and after control is complete, disease investigation is carried out after 10-12 days.
The activity data of each individual active component of the invention for controlling leaf spot disease of peanut are shown in Table 55.
The activity data and the synergistic effect of the composition for preventing and treating the leaf spot disease of the peanut are shown in table 56.
The results in Table 56 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on peanut leaf spot in the range of the test proportion.
TABLE 55 Activity of individual active Components
TABLE 56 Activity and synergy of the compositions of the present invention
Example 28 test for controlling wheat scab
Potted two-leaf wheat seedlings of the variety "Liaochun 18" were sprayed with an aqueous solution of each active ingredient or composition (concentrations as set forth in the following table), 24 hours later, with a suspension of wheat scab spore inoculated onto leaves and cultured in a greenhouse for 5 days later, after which a full-scale disease control was performed.
The activity data of each individual active ingredient of the present invention for controlling wheat scab are shown in table 57.
The activity data and the synergistic effect of the composition for preventing and treating wheat scab are shown in Table 58.
The results in Table 58 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on wheat scab within the range of the test proportion.
TABLE 57 Activity of individual active Components
TABLE 58 Activity and synergy of the compositions of the invention and synergy
Example 29 control of Rice sheath blight disease test 1
Potted two-leaf stage rice seedlings of the variety "Long Dao" were sprayed with an aqueous solution of each active ingredient or composition (concentrations as set forth in the following table) and 24 hours later, a suspension of Rhizoctonia solani hypha was inoculated onto rice leaves and cultured in a greenhouse for 5 days later and after the control was sufficiently sick, the investigation of the disease state was carried out.
The activity data of the individual active ingredients of the present invention for controlling rice sheath blight disease are shown in Table 59.
The activity data and the synergistic effect of the composition for controlling rice sheath blight disease are shown in Table 60.
The results in Table 60 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on rice sheath blight disease in the experimental proportioning range.
TABLE 59 Activity of individual active Components
TABLE 60 Activity and synergy of the compositions of the present invention
Example 30 Rice sheath blight disease control test 2
Potted two-leaf stage rice seedlings of the variety "Long Dao" were sprayed with an aqueous solution of each active ingredient or composition (concentrations as set forth in the following table) and 24 hours later, a suspension of Rhizoctonia solani hypha was inoculated onto rice leaves and cultured in a greenhouse for 5 days later and after the control was sufficiently sick, the investigation of the disease state was carried out.
The activity data of the individual active components of the present invention for controlling rice sheath blight disease are shown in Table 61.
The activity data and the synergistic effect of the composition for controlling rice sheath blight disease are shown in Table 62.
The results in Table 62 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on rice sheath blight disease in the experimental proportioning range.
TABLE 61 Activity of the individual active ingredients
TABLE 62 Activity and synergy of the compositions of the present invention
EXAMPLE 31 test for controlling bacterial leaf blight of Rice
The rice (the variety is the more light) is planted in the same pot of a greenhouse, 8 plants/pot are sprayed with the water solution of each active component or composition when the rice grows to the four-leaf period, after 24 hours, the activated rice bacterial leaf blight strain is uniformly sprayed on rice leaves, and the rice leaves are moisturized for 24 hours by artificial air and then are moved into the greenhouse for continuous culture. After the fresh water control was sufficiently sick, the leaf spot length of each treatment was measured, and the disease inhibition rate, i.e., the observation efficacy, was calculated by the following formula.
The activity data of each individual active component for preventing and treating bacterial leaf blight of rice are shown in Table 63.
The activity data and the synergistic effect of the composition for preventing and treating bacterial leaf blight of rice are shown in Table 64.
The results in Table 64 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on bacterial leaf blight of rice in the experimental proportioning range.
TABLE 63 Activity of individual active Components
TABLE 64 Activity and synergy of the compositions of the present invention
EXAMPLE 32 treatment test for Capsici fructus anthracnose
Inoculating six-leaf stage pepper seedling of green pepper into spore suspension of pepper anthracnose pathogen, culturing in climatic chamber for 24 hr, spraying with water solution of each active component or composition (with effective component concentration as shown in the following table), transferring into greenhouse, culturing, and performing disease investigation after control is complete for 5-7 days.
The data of the therapeutic activity of each individual active ingredient and composition of the present invention against pepper anthracnose is shown in tables 65, 66.
The results in tables 65 and 66 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on pepper anthracnose in the experimental proportioning range.
Table 65 synergistic effects of the active ingredients and compositions
Therapeutic effects of Table 66 active ingredients and synergistic effects of the compositions
EXAMPLE 33 efficacy-sustaining test for controlling powdery mildew of Capsici fructus
Spraying the potted six-leaf stage pepper seedling of green round pepper with water solution of each active component or composition (the concentration of the active components is shown in the table below), spraying the pepper powdery mildew spores on the back of the leaves after 1 day, 3 days, 5 days, 7 days and 10 days, culturing in a greenhouse, and carrying out disease investigation after the contrast is fully developed for 20-25 days.
The activity data of each individual active component and the composition for preventing and treating powdery mildew of capsicum are shown in Table 67.
The results in table 67 below show that the observed efficacy of the individual components and compositions of the present invention against pepper powdery mildew gradually decreases as the time of vaccination increases after the drug; at the same concentration, the inoculation is carried out 5 days after the medicine, the observed efficacy of the individual components is 50% lower, and the observed efficacy of the composition is higher than 60%; the composition is inoculated 10 days after the medicine, the observation efficacy of the individual components is not obvious, the observation efficacy of the composition is about 30%, and the composition shows obvious control effect. The individual components of the invention are used in the form of a composition, which enhances the lasting activity of the medicament on pepper powdery mildew.
Sustained activity and synergistic effect of table 67 active components
EXAMPLE 34 field test for controlling powdery mildew of cucumber
In the sunlight greenhouse, in the middle of powdery mildew of cucumber (variety "fruit cucumber"), the aqueous solutions of each active component or composition (the concentrations are shown in the following table) were sprayed, and after 15 days, the investigation of the disease state was carried out.
The activity data of each independent active component for preventing and treating powdery mildew of cucumber are shown in table 68.
The activity data and the synergistic effect of the composition for preventing and treating powdery mildew of cucumber are shown in Table 69.
The results in Table 69 below show that the observed efficacy (C obs ) And expected efficacy (C) exp ) All of the ratio of (3)>1, the composition shows a synergistic effect on powdery mildew of cucumber in the field in a test proportioning range.
TABLE 68 Activity of individual active Components
TABLE 69 Activity and synergism of the compositions of the inventionAs same asAction

Claims (10)

1. A bactericidal composition characterized in that: the composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99:1;
wherein the active component A is one or more of pyrimidine-containing substituted pyrazole compounds or salts thereof; the active component B is selected from a bactericide.
2. The bactericidal composition of claim 1 wherein: the pyrimidine-containing substituted pyrazole compound is a compound shown in a general formula I-A or I-B or a salt thereof:
wherein:
R 1 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkynyl, C 3 -C 4 Alkenyloxy, halogenated C 3 -C 4 Alkenyloxy, C 3 -C 4 Alkynyloxy, halogenated C 3 -C 4 Alkynyloxy, C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylaminocarbonyl, halo C 1 -C 4 Alkylamino groupCarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl or C 1 -C 4 Alkylthio C 1 -C 4 An alkyl group;
R 2 selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group;
R 3 selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkynyl, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, C 1 -C 4 Alkylsulfinyl, halo C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, haloC 1 -C 4 Alkylsulfonyl, C 1 -C 4 Alkylaminosulfonyl, di (C) 1 -C 4 Alkyl) sulfamoyl, C 1 -C 4 Alkylsulfonylaminocarbonyl, C 1 -C 4 Alkylcarbonylaminosulfonyl, C 3 -C 4 Cycloalkyl-oxycarbonyl, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylcarbonyl C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, C 1 -C 4 Alkylaminocarbonyl, di (C) 1 -C 4 Alkyl) aminocarbonyl, C 2 -C 4 Alkenyloxycarbonyl, C 2 -C 4 Alkynyloxycarbonyl, C 1 -C 4 Alkoxy C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkylaminothio, di (C) 1 -C 4 Alkyl) aminothio, arylcarbonyl C 1 -C 4 Alkyl, arylcarbonyl, aryloxycarbonyl, arylC 1 -C 4 Alkyloxycarbonyl, aryl C 1 -C 4 Alkyl, heteroaryl carbonyl C 1 -C 4 Alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroaryl C 1 -C 4 Alkyloxycarbonyl or heteroaryl C 1 -C 4 An alkyl group;
R 4 、R 5 may be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 4 、R 5 C connected with it can also form C 3 -C 4 Is a ring of (2);
R 6 、R 7 may be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; wherein R is 6 、R 7 C connected with it can also form C 3 -C 4 Is a ring of (2);
R 8 、R 9 may be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl, unsubstituted or substituted by 1-5R 11 Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl A radical, heteroarylmethylcarbonyl or heteroaryloxycarbonyl;
R 11 selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, C 2 -C 4 Alkenyloxy, halogenated C 2 -C 4 Alkenyloxy, C 2 -C 4 Alkynyloxy, halogenated C 2 -C 4 Alkynyloxy, C 1 -C 4 Alkylsulfonyl, haloC 1 -C 4 Alkylsulfonyl, C 1 -C 4 Alkylcarbonyl, halo C 1 -C 4 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, halo C 1 -C 4 Alkoxycarbonyl group, C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxy C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkoxycarbonyl group C 1 -C 4 Alkyl, C 1 -C 4 Alkylthio carbonyl C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkylthio carbonyl C 1 -C 4 Alkyl, C 1 -C 4 Alkylcarbonyloxy, haloC 1 -C 4 Alkylcarbonyloxy, C 1 -C 4 Alkoxycarbonyloxy, halo C 1 -C 4 Alkoxycarbonyloxy, C 1 -C 4 Alkylsulfonyloxy, halogenated C 1 -C 4 Alkylsulfonyloxy, C 1 -C 4 Alkoxy C 1 -C 4 Alkoxy or halo C 1 -C 4 Alkoxy C 1 -C 4 An alkoxy group; n is selected from integers from 0 to 5, R when n is greater than 1 11 May be the same or different;
R 14 、R 15 、R 16 Or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy or C 3 -C 4 Cycloalkyl;
w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or C 1 -C 4 An alkylsulfonyl group;
the salts of the pyrimidine-containing substituted pyrazole compounds are salts formed by compounds shown in the general formula I-A or I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
the active component B is selected from multi-site inhibitor bactericides.
3. The bactericidal composition of claim 1 or 2, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:50-50:1;
wherein the active component A is selected from one or more of compounds in the general formula I-A or salts thereof;
wherein: r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 Alkylthio; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl or C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-A is the salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
The active component B is selected from zineb (zineb) B134, mancozeb B135, metiram B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, sodium zineb (nabam) B140, mancozeb (zeb) B141, mancozeb 142, mancozeb 143, furben-zene (cufraneb) B144, sulfur (sulfophur) B145, dichlormid (anilazine) B146, captan (captan) B147, fenamic (fenamic) B148, chlorothalonil (chloranil) B149, benzosulfonamide (dichlormid) B150, tolu-fluoro (tolfenpyrad) B151, dicyandiamide (dicyandiamide) B152, fluoroimine (fluoroimine) B153 Sulfofacil (metasulfocarb) B154, captafol (captafol) B155, folpet (folpet) B156, iminoctadine (iminoctadine) B157, biguanide (guazatin) B158, zinc thiazole (zinothiazole) B159, copper quinoline (oxa-coppers) B160, copper thiabendazole (thiodiazole-coppers) B161, copper nonoxide (cuppric nonylphenolsulfonate) B162, picarbazox B163, aminopyrafen B164, metyltetraprole B165, dodine (dodine) B166, pyridachlometyl B, pyridazone (dicyclazine) B168, validamycin (validamycin) B169, azohydrazone (ferrozon) B170, teflozon B171, imidazoxin (triazoxin) B172, quinomefurone B173, flubenzofuranone B174, or several other than one of them 176.
4. A bactericidal composition as claimed in claim 3, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:20-20:1;
wherein the active component A is one or more of compounds shown in the general formula I-A or salts thereof;
wherein R is 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy group,C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino or haloC 1 -C 4 An alkylamino group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and are each selected from hydrogen, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from one or more of zineb (zineb) B134, mancozeb B135, metiram B136, propineb (propineb) B137, captan (captan) B147, chlorothalonil (chlorothalonil) B149, zinc thiazole B159, copper quinoline (oxamine-coupler) B160, copper thiabendazole (thiodicazole-coupler) B161, picarbazox B163, aminopyrafen B164, metyltetraprole B, validamycin (validamycin) B169, quinofumelin B173, ipflufequinone B174, dipyridamole B175 and teclothiam B176.
5. The bactericidal composition of claim 4 wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:10-10:1;
Wherein the active component A is selected from one or more of compounds in the general formula I-A or salts thereof;
wherein R is 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r is R 4 、R 5 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 6 、R 7 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 8 、R 9 May be the same or different and are each selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; r is R 14 、R 15 、R 16 Or R is 17 May be the same or different and is selected from hydrogen, halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from one or more of zineb (zineb) B134, mancozeb B135, metiram (metiram) B136, propineb (propineb) B137, captan (captan) B147, chlorothalonil (chlorothalonil) B149, zinc thiazole (zinc thiazole) B159, copper quinoline (oxamine-coupler) B160, picarbazox B163, aminopyrafen B164 and metyltetraprole B.
6. The bactericidal composition of claim 1 or 2, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:50-50:1;
wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio, halo C 1 -C 4 Alkylthio, C 1 -C 4 Alkylsulfinyl, C 1 -C 4 Alkylsulfonyl, C 2 -C 4 Alkenyl, halo C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl or halo C 2 -C 4 Alkynyl; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino, halo C 1 -C 4 Alkylamino, di (C) 1 -C 4 Alkyl) amino, halo di (C) 1 -C 4 Alkyl) amino or C 1 -C 4 Alkylthio; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-B is the salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from zineb (zineb) B134, mancozeb B135, metiram B136, propineb (propineb) B137, maneb (maneb) B138, amobam (amobam) B139, sodium zineb (nabam) B140, mancozeb (zeb) B141, mancozeb 142, mancozeb 143, furben-zene (cufraneb) B144, sulfur (sulfophur) B145, dichlormid (anilazine) B146, captan (captan) B147, fenamic (fenamic) B148, chlorothalonil (chloranil) B149, benzosulfonamide (dichlormid) B150, tolu-fluoro (tolfenpyrad) B151, dicyandiamide (dicyandiamide) B152, fluoroimine (fluoroimine) B153 Sulfofacil (metasulfocarb) B154, captafol (captafol) B155, folpet (folpet) B156, iminoctadine (iminoctadine) B157, biguanide (guazatin) B158, zinc thiazole (zinothiazole) B159, copper quinoline (oxa-coppers) B160, copper thiabendazole (thiodiazole-coppers) B161, copper nonoxide (cuppric nonylphenolsulfonate) B162, picarbazox B163, aminopyrafen B164, metyltetraprole B165, dodine (dodine) B166, pyridachlometyl B, pyridazone (dicyclazine) B168, validamycin (validamycin) B169, azohydrazone (ferrozon) B170, teflozon B171, imidazoxin (triazoxin) B172, quinomefurone B173, flubenzofuranone B174, or several other than one of them 176.
7. The bactericidal composition of claim 6 wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:20-20:1;
wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C 1 -C 4 Alkyl or halo C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 Alkenyl, C 2 -C 4 Alkynyl, halo C 2 -C 4 Alkenyl or halo C 2 -C 4 Alkynyl; r is R 4 、R 5 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 6 、R 7 May be the same or different and are respectively selected from hydrogen, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy or halo C 1 -C 4 An alkoxy group; r is R 8 、R 9 May be the same or different and are respectively selected from hydrogen, cyano, halogen and C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxycarbonyl or halogen C 1 -C 4 An alkoxycarbonyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkylamino or haloC 1 -C 4 An alkylamino group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 3 -C 4 Cycloalkyl, C 1 -C 4 Alkoxy or C 1 -C 4 Alkylthio;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from one or more of zineb (zineb) B134, mancozeb B135, metiram B136, propineb (propineb) B137, captan (captan) B147, chlorothalonil (chlorothalonil) B149, zinc thiazole B159, copper quinoline (oxamine-coupler) B160, copper thiabendazole (thiodicazole-coupler) B161, picarbazox B163, aminopyrafen B164, metyltetraprole B, validamycin (validamycin) B169, quinofumelin B173, ipflufequinone B174, dipyridamole B175 and teclothiam B176.
8. The bactericidal composition of claim 7 wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:10-10:1;
Wherein the active component A is selected from one or more of compounds in the general formula I-B or salts thereof;
wherein R is 1 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C 1 -C 4 An alkyl group; r is R 2 Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C 1 -C 4 An alkyl group; r is R 3 Selected from hydrogen, hydroxy, formyl or C 1 -C 4 An alkyl group; r is R 4 、R 5 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 6 、R 7 May be the same or different and are each selected from hydrogen, halogen or C 1 -C 4 An alkyl group; r is R 8 、R 9 May be the same or different and are each selected from hydrogen, cyano, halogen or C 1 -C 4 An alkyl group; r is R 11 Selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 An alkyl group; n is an integer from 0 to 5, and when n is 0, the benzene ring has no substituent; when n is greater than 1, R 11 May be the same or different; w is selected from hydrogen, halogen or C 1 -C 4 An alkyl group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from one or more of zineb (zineb) B134, mancozeb B135, metiram (metiram) B136, propineb (propineb) B137, captan (captan) B147, chlorothalonil (chlorothalonil) B149, zinc thiazole (zinc thiazole) B159, copper quinoline (oxamine-coupler) B160, picarbazox B163, aminopyrafen B164 and metyltetraprole B.
9. Use of the bactericidal composition of claim 1, wherein: the bactericidal composition is used for preparing medicines for preventing and treating plant pathogenic fungi and bacterial diseases.
10. Use of a bactericidal composition as claimed in claim 6, wherein: the plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, banded sclerotial blight, damping-off, black mole, downy mildew, late blight, epidemic disease, downy mildew, black shank, cotton rot, damping-off, cotton blight, white rust, black spot, leaf spot, brown spot, soft rot, bacterial leaf blight, bacterial wilt, ulcer or yellow dragon.
CN202310611109.8A 2019-11-25 2020-11-20 Sterilization composition and application thereof Pending CN116711727A (en)

Applications Claiming Priority (33)

Application Number Priority Date Filing Date Title
CN2019111684534 2019-11-25
CN201911168465 2019-11-25
CN2019111682492 2019-11-25
CN2019111670033 2019-11-25
CN201911167003 2019-11-25
CN201911166996 2019-11-25
CN2019111669962 2019-11-25
CN2019111684657 2019-11-25
CN201911167031 2019-11-25
CN2019111670315 2019-11-25
CN201911168249 2019-11-25
CN201911168453 2019-11-25
CN2020101860227 2020-03-17
CN202010186297 2020-03-17
CN202010186022 2020-03-17
CN2020101862970 2020-03-17
CN202010522094 2020-06-10
CN202010522097 2020-06-10
CN2020105220978 2020-06-10
CN2020105220944 2020-06-10
CN2020109870994 2020-09-18
CN2020109850365 2020-09-18
CN202010985009 2020-09-18
CN202010985036 2020-09-18
CN202010987118 2020-09-18
CN2020109871361 2020-09-18
CN202010987099 2020-09-18
CN202010987136 2020-09-18
CN202010985026 2020-09-18
CN2020109850261 2020-09-18
CN2020109871183 2020-09-18
CN2020109850098 2020-09-18
CN202011314120.0A CN112825859B (en) 2019-11-25 2020-11-20 Bactericidal composition and application thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202011314120.0A Division CN112825859B (en) 2019-11-25 2020-11-20 Bactericidal composition and application thereof

Publications (1)

Publication Number Publication Date
CN116711727A true CN116711727A (en) 2023-09-08

Family

ID=75923238

Family Applications (6)

Application Number Title Priority Date Filing Date
CN202310611255.0A Pending CN117016551A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202210553242.8A Active CN114903046B (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202011314120.0A Active CN112825859B (en) 2019-11-25 2020-11-20 Bactericidal composition and application thereof
CN202310611195.2A Pending CN117016550A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202310611109.8A Pending CN116711727A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202310611327.1A Pending CN118058288A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CN202310611255.0A Pending CN117016551A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202210553242.8A Active CN114903046B (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof
CN202011314120.0A Active CN112825859B (en) 2019-11-25 2020-11-20 Bactericidal composition and application thereof
CN202310611195.2A Pending CN117016550A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202310611327.1A Pending CN118058288A (en) 2019-11-25 2020-11-20 Sterilization composition and application thereof

Country Status (2)

Country Link
CN (6) CN117016551A (en)
WO (1) WO2021104171A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2932925B2 (en) * 2021-07-21 2023-09-25 Qiuhua Huang A USE OF FUNGICIDAL COMPOSITION
WO2024007376A1 (en) * 2022-07-05 2024-01-11 浙江省化工研究院有限公司 Fungicidal compositions and uses thereof in prevention and treatment of fusarium diseases of crops
CN115868396B (en) * 2022-12-16 2024-05-24 广西南亚热带农业科学研究所 Ecological seedling raising substrate for macadimia nuts
CN116267976A (en) * 2023-01-14 2023-06-23 青岛滕润翔检测评价有限公司 Sterilization combination and application thereof
CN116210700B (en) * 2023-02-16 2024-09-17 信阳农林学院 Sterilization composition for preventing and treating strawberry anthracnose
CN118383378B (en) * 2024-06-24 2024-09-06 江门市植保有限公司 Composition containing benzovindiflupyr and kasugamycin and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0720943B2 (en) * 1988-08-19 1995-03-08 宇部興産株式会社 Aminopyrimidine derivative, its manufacturing method and insecticide / bactericide
AU7551894A (en) * 1993-09-09 1995-03-27 E.I. Du Pont De Nemours And Company Fungicidal, miticidal and arthropodicidal aminopyrimidines
EP3702355B1 (en) * 2015-05-18 2022-01-12 Shenyang Sinochem Agrochemicals R&D Co., Ltd. Substituted pyrazole compounds containing pyrimidine, the preparation and application thereof
CN108059629B (en) * 2016-11-08 2021-04-02 沈阳中化农药化工研发有限公司 Pyrimidine-containing substituted pyrazole compound and preparation method and application thereof
CN109836417A (en) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 Substituted uracil compound and preparation method thereof and purposes as fungicide
CN109836418A (en) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 Substituted pyrazolecarboxylic class compound and preparation method thereof and purposes as insecticidal/acaricidal agent
CN111316992B (en) * 2018-12-14 2021-07-20 沈阳中化农药化工研发有限公司 Fungicidal composition and application thereof
CN111316991B (en) * 2018-12-14 2021-07-20 沈阳中化农药化工研发有限公司 Fungicidal compositions and uses
CN111316990B (en) * 2018-12-14 2021-06-25 沈阳中化农药化工研发有限公司 Fungicidal compositions and their use
CN111316987B (en) * 2018-12-14 2021-06-29 沈阳中化农药化工研发有限公司 Fungicidal composition and application thereof

Also Published As

Publication number Publication date
WO2021104171A1 (en) 2021-06-03
CN117016551A (en) 2023-11-10
CN114903046A (en) 2022-08-16
CN112825859B (en) 2022-06-14
CN117016550A (en) 2023-11-10
CN118058288A (en) 2024-05-24
CN114903046B (en) 2023-06-16
CN112825859A (en) 2021-05-25

Similar Documents

Publication Publication Date Title
CN114903046B (en) Sterilization composition and application thereof
KR101302266B1 (en) Fungicidal mixtures of thiophene derivative
CN111316987B (en) Fungicidal composition and application thereof
KR20070084423A (en) Agricultural or horticultural bactericide composition and method of controlling plant disease
CN102302025A (en) Bactericidal composition containing pyraclostrobin and thiocarbamate
JP2015020978A (en) Plant grow promoting method
CN109805018A (en) A kind of Fungicidal composition and application
JP2016199526A (en) Agricultural and horticultural bactericide composition
CN111316990B (en) Fungicidal compositions and their use
CN111316991B (en) Fungicidal compositions and uses
CN111316992B (en) Fungicidal composition and application thereof
WO2021004195A1 (en) Fungicidal and bactericidal composition and application
CN105532696B (en) Fungicidal composition and its application
CN112189660B (en) Fungicidal and bacterial compositions and uses thereof
CN103651395B (en) Sterilization composition
CN114532346B (en) Fungicidal and bacterial composition and application thereof
CN112189668B (en) Fungicidal and bacterial composition and application
CN109717194A (en) A kind of bactericidal composition
CN112189669B (en) Fungicidal and bacterial compositions and uses
CN112189663B (en) Fungicidal and bacterial composition and application
CN116349686A (en) Fungicidal composition containing substituted triazolinone ether compound and application thereof
CN116349683A (en) Fungicidal composition containing substituted triazolinone ether compound and application thereof
CN116349682A (en) Fungicidal composition containing cell wall synthesis inhibitor bactericides and application thereof
CN116349684A (en) Fungicidal composition containing sterol biosynthesis inhibitor bactericide and application thereof
CN111109269A (en) Bactericidal composition

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination