CN114869946A - Traditional Chinese medicine wax moxibustion phase change paste and preparation and use methods thereof - Google Patents

Traditional Chinese medicine wax moxibustion phase change paste and preparation and use methods thereof Download PDF

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CN114869946A
CN114869946A CN202210685010.8A CN202210685010A CN114869946A CN 114869946 A CN114869946 A CN 114869946A CN 202210685010 A CN202210685010 A CN 202210685010A CN 114869946 A CN114869946 A CN 114869946A
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parts
chinese medicine
traditional chinese
paste
wax moxibustion
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CN114869946B (en
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典迎彬
高志红
王旭洋
胡艳丽
丁遥
马音音
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First Affiliated Hospital of Henan University of TCM
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First Affiliated Hospital of Henan University of TCM
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235Foeniculum (fennel)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a traditional Chinese medicine wax moxibustion phase change paste and a preparation and use method thereof, wherein the traditional Chinese medicine wax moxibustion phase change paste comprises the following raw materials: medical paraffin, medical vaseline and various traditional Chinese medicine powders. The melting point, hardness and cohesiveness of the traditional Chinese medicine wax moxibustion phase-change paste are adjusted by adding the medical vaseline, the risk of low-temperature scalding is reduced, the use safety is improved, compared with the traditional wax moxibustion paste, the traditional wax moxibustion paste has the effects of softness without separation and hardness without dispersion, the plasticity of the traditional Chinese medicine wax moxibustion phase-change paste is increased, the fitness with a human body is improved, the medicine uniformity of the phase-change paste is improved, and the repeated use is more convenient; the radix angelicae dahuricae is added, so that the problem of greasy skin of the existing wax moxibustion cream is solved, and the use experience of the traditional Chinese medicine wax moxibustion phase-change cream is greatly improved.

Description

Traditional Chinese medicine wax moxibustion phase change paste and preparation and use methods thereof
Technical Field
The invention belongs to the field of traditional Chinese medicine external use drugs, and particularly relates to a traditional Chinese medicine wax moxibustion phase change paste and a preparation method and a use method thereof.
Background
The traditional Chinese medicine wax moxibustion ointment is a practical traditional Chinese medicine external treatment technology which combines the wax therapy and the medicinal moxibustion extension, combines the traditional Chinese medicine technology and the modern medical technology, and achieves the effects of warming channel and dispelling cold, activating blood and relieving pain, and dispelling wind and removing dampness by applying the traditional Chinese medicine wax moxibustion ointment to the affected part or acupuncture points of a human body and utilizing the medicinal action of the traditional Chinese medicine and the heat conduction and mechanical action of the wax therapy.
The raw materials used in the common wax therapy are medical paraffin, the wax therapy only has the functions of heat conduction and mechanical pressure, the unique effect of the traditional Chinese medicine cannot be realized, and the texture is crisp and fragile, and is not easy to adhere to the concave-convex articular surface; although the traditional Chinese medicine has good permeation effect, the medicine moxibustion has low thermal capacity and large heat conductivity coefficient, has higher requirement on temperature accuracy in operation, is easy to cause scald, is not easy to smear and is easy to crack in use.
The inventor tries the existing traditional Chinese medicine wax moxibustion paste on the market, and finds that the following problems exist: the existing traditional Chinese medicine wax moxibustion ointment usually directly uses paraffin as a phase change material, but the phase change temperature of the paraffin exceeds 45 ℃, and the low-temperature scalding risk is increased when the paraffin is attached to human skin for a long time, so that the melting point of the traditional Chinese medicine wax moxibustion ointment needs to be adjusted. In addition, when the inventor uses the conventional paraffin-based wax moxibustion paste which is commonly available on the market, the inventor finds that the conventional wax moxibustion paste is not strong in cohesiveness when being peeled from the skin of a human body after being used, and the medicine powder and the wax base are easy to separate (hard and scattered), so that the phenomenon that some traditional Chinese medicine fine powder and the wax base stain the skin is caused, and the phenomenon that the medicine powder and the wax base are layered (soft and divided) is easy to occur when being heated and melted, and the medicine powder and the wax base are required to be fully stirred in condensation to be uniformly mixed again, so that the operation of the conventional paraffin-based wax moxibustion paste is very troublesome when being repeatedly used. In addition, after the traditional wax moxibustion ointment is used and the skin is peeled off, the patient reflects that the skin is greasy, which indicates that more low-melting-point wax oil is remained on the skin.
Disclosure of Invention
Aiming at the defects and disadvantages in the prior art, the invention provides a traditional Chinese medicine wax moxibustion phase-change paste with the phase-change temperature of 40-45 ℃ and a preparation and use method thereof, wherein medical paraffin and medical vaseline are mainly compounded in proportion to achieve the purpose of reducing the melting point of the traditional Chinese medicine wax moxibustion phase-change paste.
In order to solve the technical problems, the invention provides the following technical scheme:
a traditional Chinese medicine wax moxibustion phase change ointment is characterized by comprising medical paraffin, medical vaseline and traditional Chinese medicine fine powder.
Preferably, each part by weight of the traditional Chinese medicine wax moxibustion phase change cream comprises 520 parts by weight of 450-one medicine paraffin, 40-70 parts by weight of medical vaseline and 300 parts by weight of 200-one medicine powder, wherein each part by weight of the traditional Chinese medicine powder comprises 10-20 parts by weight of radix angelicae pubescentis, 25-30 parts by weight of parasitic loranthus, 10-20 parts by weight of eucommia ulmoides, 15-25 parts by weight of radix cyathulae, 8-12 parts by weight of frankincense, 8-14 parts by weight of myrrh, 25-30 parts by weight of rheum officinale, 3-8 parts by weight of pericarpium zanthoxyli, 3-6 parts by weight of borneol, 4-5 parts by weight of fennel, 8-10 parts by weight of pericarpium citri reticulatae viride, 10-15 parts by weight of rhizoma corydalis, 15-20 parts by weight of ground beeltle, 25-35 parts by weight of lycopodium clavatum, 20-35 parts by weight of caulis spatholobi and 5-10 parts by weight of radix angelicae.
In addition, the invention also provides a preparation method of the traditional Chinese medicine wax moxibustion phase change paste, which is characterized by comprising the following steps:
(1) weighing 10-20 parts of radix angelicae pubescentis, 25-30 parts of parasitic loranthus, 10-20 parts of eucommia ulmoides, 15-25 parts of medicinal cyathula root, 8-12 parts of frankincense, 8-14 parts of myrrh, 25-30 parts of rheum officinale, 3-8 parts of pericarpium zanthoxyli, 3-6 parts of borneol, 4-5 parts of fennel, 8-10 parts of pericarpium citri reticulatae viride, 10-15 parts of rhizoma corydalis, 15-20 parts of ground beeltle, 25-35 parts of lycopodium clavatum, 20-35 parts of caulis spatholobi and 5-10 parts of radix angelicae, crushing into 200-mesh fine powder, and uniformly mixing for later use;
(2) and then heating and melting the medical paraffin to liquid state, adding the medical vaseline, continuously stirring until the medical paraffin is completely melted and uniformly mixed, adding the traditional Chinese medicine fine powder prepared in advance in the step (1), uniformly stirring, continuously heating until the traditional Chinese medicine fine powder is completely melted into thin paste, pouring the thin paste into a clean container with a cover, sealing and storing at normal temperature.
Preferably, the clean container with the cover can be made of polypropylene transparent lunch boxes.
In addition, the invention also provides a use method of the traditional Chinese medicine wax moxibustion phase change paste, which is characterized by comprising the following steps:
1) putting the traditional Chinese medicine wax moxibustion phase change paste into a microwave oven, and heating for 5 minutes to melt the paste into flowable thin paste again;
2) slowly pouring the thin pasty traditional Chinese medicine wax moxibustion phase change paste obtained in the step 1) onto a preservative film to enable the paste to automatically flow and spread into a thin cake shape, standing and cooling, covering a layer of mulberry paper after the surface of the thin pasty traditional Chinese medicine wax moxibustion phase change paste loses luster and does not flow, and then tightly attaching one side of the mulberry paper of the traditional Chinese medicine wax moxibustion phase change paste to the skin of a certain part of a human body;
3) then, covering clothes on the preservative film or applying a heat preservation bag, removing the traditional Chinese medicine wax moxibustion phase change cream after the heat felt by the human body is dissipated, and hardening the traditional Chinese medicine wax moxibustion phase change cream into a thin cake which is fit with the curve of the human body part;
4) cutting the traditional Chinese medicine wax moxibustion phase change paste obtained in the step 3) into small pieces, putting the small pieces into a clean container with a cover, sealing and storing at normal temperature for the next use.
Preferably, the traditional Chinese medicine wax moxibustion phase change ointment can be reused for 10 times at most.
In the invention, the medical paraffin has large heat capacity and small heat conductivity, and is not suitable for scald; slow heat dissipation, strong heat preservation capability and continuous action for improving blood circulation; has plasticity and viscosity, and can exert mechanical compression effect on the treated part during cooling and solidifying process, promote absorption of edema, transfer heat to deep tissue, and soften scar and connective tissue adhesion.
According to the invention, the medical vaseline has small irritation to the skin, and can play a role in softening the traditional Chinese medicine wax moxibustion phase-change paste by adding the traditional Chinese medicine wax moxibustion phase-change paste, so that the melting point and hardness of the wax moxibustion paste can be reduced, the traditional Chinese medicine wax moxibustion phase-change paste is soft and not dispersed (when the paste is melted and softened, medicinal powder, medical paraffin and medical vaseline are uniformly mixed, gravity layering does not occur), and the traditional Chinese medicine wax moxibustion phase-change paste is hard and not dispersed (when the paste is cooled, solidified and hardened, the whole paste has good molding plasticity, no fracture and cracking occur, and fragments are generated to pollute the skin), and the low-temperature scald to the skin caused by long-time use of the traditional Chinese medicine wax moxibustion phase-change paste can be prevented, so that the irreversible injury to the skin is avoided. Test data show that the melting point range of the traditional Chinese medicine wax moxibustion phase change paste can be effectively reduced to 40-45 ℃ by adopting the component proportion of the medical paraffin and the medical vaseline.
The mistletoe and the eucommia bark in the traditional Chinese medicine fine powder can strengthen the muscles and bones; radix Angelicae Pubescentis, pericarpium Citri Reticulatae viride, rhizoma corydalis, herba Lycopodii, and Olibanum for dredging collaterals and relieving pain; radix Cyathulae, radix et rhizoma Rhei, Myrrha, Eupolyphaga Seu Steleophaga, caulis Spatholobi can promote blood circulation for removing blood stasis; the pericarpium zanthoxyli, the borneol and the fennel have the functions of dispelling cold and relieving pain, have aromatic substances, can improve the comprehensive effect of permeable traditional Chinese medicine fine powder of the active ingredients of the traditional Chinese medicines, can obviously improve the blood circulation state of a human body, and prevent diseases; simultaneously has the effects of strengthening tendons and bones, warming and activating meridian, promoting blood circulation by removing blood stasis, dispelling cold and relieving pain, and can effectively improve the uncomfortable symptoms of cervical spondylosis, lumbar disc herniation, knee osteoarthritis, scapulohumeral periarthritis, mastitis, chronic prostatitis, pelvic effusion and other diseases. In the traditional Chinese medicine fine powder, lignans and flavonoids of loranthus parasiticus and eucommia ulmoides, phenylpropanoids of radix angelicae pubescentis, volatile oils and flavonoids of pericarpium citri reticulatae viride, various alkaloids of rhizoma corydalis and lycopodium clavatum, volatile oils of frankincense and myrrh, sterols of radix cyathulae, anthraquinones of rheum officinale, n-hexane and n-butanol of ground beeltle and flavonoids of caulis spatholobi are main effective components, and the traditional Chinese medicine fine powder has the effects of promoting blood circulation, resisting bacteria, diminishing inflammation, relieving pain and promoting body immunity.
The radix angelicae powder has viscosity and adsorbability similar to flour, so that the cohesiveness of the traditional Chinese medicine wax moxibustion phase-change cream can be increased, the adsorption effect on low-melting-point oily substances in medical paraffin and medical vaseline is increased, and then the precipitation of the low-melting-point oily substances in the medical vaseline is reduced, so that the technical effect of stickiness without sticking is realized, namely, when the traditional Chinese medicine wax moxibustion phase-change cream is separated from the skin after use, the residual quantity of wax oil is reduced, the skin of a human body is not stained, and the greasy feeling of the traditional Chinese medicine wax moxibustion phase-change cream on the skin is reduced.
Compared with the prior art, the invention can obtain the following beneficial effects:
(1) the external traditional Chinese medicine wax moxibustion phase change paste is added with a plurality of traditional Chinese medicines, can realize unique functions of promoting blood circulation to remove blood stasis, regulating qi activity, strengthening tendons and bones, dredging collaterals and relieving pain, and has good curative effect, quick response, safety and no side effect; the medical paraffin is added, so that the heat dissipation is slow, the heat preservation capability is strong, the medicine absorption can be accelerated, the medicine components can be transferred to deep tissues by means of heat, scars and connective tissue adhesion are softened, and the blood circulation is continuously improved;
(2) the invention adds medical vaseline which is nontoxic and harmless, can improve the sealing property, the ductility and the dry cracking resistance of the traditional Chinese medicine wax moxibustion phase change paste, moisturize and moisten the traditional Chinese medicine wax moxibustion phase change paste, so that the traditional Chinese medicine wax moxibustion phase change paste achieves the effects of good plasticity, softness without layering (namely when the paste is melted and softened, the medicine powder, the paraffin and the vaseline are uniformly mixed, gravity layering does not occur, medicine components and a matrix can not be layered when the paste is solidified, and the effect of the medicine components on heat permeation can be prevented from being reduced, through repeated tests, the 200-mesh particle size of the traditional Chinese medicine fine powder is selected to solve the problem of uniform mixing of the medicine powder and the matrix, which plays a key role in the invention), and hardness without scattering (namely when the paste is cooled, solidified and hardened, the whole paste has good molding plasticity and is not cracked), thereby avoiding the defects of premature reduction and easy reduction of the plasticity and the dispersion of the paste when the traditional Chinese medicine wax moxibustion phase change paste is repeatedly recycled, thereby improving the repeated use times of the traditional Chinese medicine wax moxibustion phase change ointment. The test result shows that the traditional Chinese medicine wax moxibustion phase change ointment can be stably and repeatedly used for 10 times.
(3) Through the compounding of the medical paraffin and the medical vaseline, the phase change melting point of the single medical paraffin-based wax moxibustion paste is reduced, and the material ratio used in the application can reduce the integral melting point of the traditional Chinese medicine wax moxibustion phase change paste from about 53 ℃ to 40-45 ℃, so that the phenomenon of low-temperature scald possibly caused by the fact that human skin is contacted with materials higher than 45 ℃ for a long time is avoided, and the use safety of the traditional Chinese medicine wax moxibustion phase change paste is greatly improved.
(4) The radix angelicae powder has viscosity and adsorbability similar to flour, so that the cohesiveness of the traditional Chinese medicine wax moxibustion phase-change paste can be increased, the adsorption effect on low-melting-point oily substances in medical paraffin and medical vaseline is increased, the precipitation of partial low-melting-point wax oil in the cooling process is reduced, the technical effect of being sticky and not sticky is realized, namely, when the traditional Chinese medicine wax moxibustion phase-change paste is separated from the skin after being used, the residual quantity of the wax oil on the surface of the skin is reduced, the skin of a human body is not polluted, and the greasy feeling of the skin is easily caused after the traditional Chinese medicine wax moxibustion phase-change paste is used.
Drawings
FIG. 1A Chinese medicinal liquid in form of wax moxibustion phase-change paste
FIG. 2 flow chart of preparation of Chinese medicinal wax moxibustion phase-change ointment
FIG. 3 flow chart of the application of the Chinese medicinal wax moxibustion phase-change ointment
Detailed Description
Example 1
A traditional Chinese medicine wax moxibustion phase change paste comprises the following components: 450g of medical paraffin, 40g of medical vaseline, 16g of radix angelicae pubescentis, 25g of parasitic loranthus, 10g of eucommia ulmoides, 15g of radix cyathulae, 8g of frankincense, 8g of myrrh, 25g of rheum officinale, 3g of pericarpium zanthoxyli, 3g of borneol, 4g of fennel, 8g of pericarpium citri reticulatae viride, 10g of rhizoma corydalis, 15g of ground beeltle, 25g of lycopodium clavatum, 20g of caulis spatholobi and 5g of radix angelicae.
The preparation method of the traditional Chinese medicine wax moxibustion phase change paste comprises the following steps:
(1) weighing 16g of radix angelicae pubescentis, 25g of parasitic loranthus, 10g of eucommia ulmoides, 15g of medicinal cyathula root, 8g of frankincense, 8g of myrrh, 25g of rheum officinale, 3g of pericarpium zanthoxyli, 3g of borneol, 4g of fennel, 8g of green tangerine peel, 10g of rhizoma corydalis, 15g of ground beeltle, 25g of lycopodium clavatum, 20g of caulis spatholobi and 5g of radix angelicae, weighing 200g in total, crushing the medicaments into 200-mesh fine powder, and uniformly mixing the fine powder for later use; weighing 450g of medical paraffin and 40g of medical vaseline;
(2) and (2) putting the medical paraffin in the step (1) into a stainless steel container, heating the medical paraffin in a water bath to melt the medical paraffin to a liquid state, adding the medical vaseline in the step (1), continuously stirring the medical vaseline to be completely melted and uniformly mixed, adding the traditional Chinese medicine fine powder prepared in advance in the step (1), uniformly stirring the traditional Chinese medicine fine powder, continuously heating the traditional Chinese medicine fine powder in a water bath to be completely melted into a thin paste, pouring the thin paste into a transparent lunch box made of polypropylene, sealing the lunch box and storing the lunch box at normal temperature.
The application method of the traditional Chinese medicine wax moxibustion phase change paste comprises the following steps:
(1) opening the cover of the sealed container which is stored at normal temperature and is filled with the traditional Chinese medicine wax moxibustion phase change cream, putting the container into a microwave oven, and heating for 5 minutes to enable the container to be melted into flowable thin paste again;
(2) slowly pouring the thin pasty traditional Chinese medicine wax moxibustion phase change paste obtained in the step (1) onto a preservative film to enable the paste to automatically flow and spread into a thin cake shape, standing and cooling, covering a layer of mulberry paper after the surface of the thin pasty traditional Chinese medicine wax moxibustion phase change paste loses luster and does not flow, and then tightly attaching one side of the mulberry paper of the traditional Chinese medicine wax moxibustion phase change paste to the skin of a certain part of a human body;
(3) then, covering clothes or applying a heat preservation bag through the preservative film, removing the traditional Chinese medicine wax moxibustion phase change cream after the heat felt by the human body is dissipated, and hardening the traditional Chinese medicine wax moxibustion phase change cream into a thin cake which is fit with the curve of the human body part;
(4) and (4) cutting the traditional Chinese medicine wax moxibustion phase change paste obtained in the step (3) into small blocks, putting the small blocks into a clean container with a cover, sealing, and storing at normal temperature for the next use.
The melting point of the wax moxibustion paste of example 1 was measured as follows:
the traditional Chinese medicine wax moxibustion phase-change paste prepared in example 1 and the box body are directly put into a microwave oven to be heated, the traditional Chinese medicine wax moxibustion phase-change paste is taken out after being changed into liquid in about 5 minutes, a thermometer (measuring range of 0-100 ℃) is quickly put into the liquid wax moxibustion paste, temperature reading is recorded every 20 seconds, and descending data of temperature along with time change is obtained, so that the melting point of the wax moxibustion paste in example 1 is 42.4 ℃, and the melting point is shown in table 1.
Examples 2 to 6
Examples 2 to 6 were prepared differently from example 1 in that the specific amounts of medical paraffin, medical vaseline and the fine powder of the chinese medicine used were different from example 1.
Comparative examples 1 to 6
The melting point of the medical paraffin 100g and the medical vaseline 100g are weighed in the comparative examples 1 and 2 respectively; the comparative example 3 is that 450g of medical paraffin is compounded with 200g of traditional Chinese medicine fine powder; comparative example 4 is that 520g of medical paraffin and 40g of medical vaseline are compounded without adding traditional Chinese medicine fine powder; the comparative example 5 is the compounding treatment when 30g of medical vaseline, 520g of medical paraffin and 200g of traditional Chinese medicine fine powder are selected; 80g of medical vaseline, 450g of medical paraffin and 200g of fine traditional Chinese medicine powder are selected for the medical vaseline used in the comparative example 6. Comparative examples 1 to 6 were prepared according to the preparation method given in example 1, and the melting point was determined according to example 1. The results of melting point measurements for comparative examples 1-6 and examples 1-6 are shown in Table 1.
TABLE 1 test data of material ratio and melting point of each treatment group
Figure BDA0003696220230000051
Figure BDA0003696220230000061
The experimental data given in table 1 show that after medical vaseline is mixed with medical paraffin according to a certain proportion, the phase-change melting point of the traditional Chinese medicine wax moxibustion phase-change paste can be well reduced, so that the use requirement of the traditional Chinese medicine wax moxibustion phase-change paste is met and low-temperature scald is avoided. The comparison of the test data of the comparative example 1 and the test data of the comparative example 3 shows that the influence degree of the traditional Chinese medicine fine powder on the melting point of the ointment is small. The weight ratio of the medical paraffin, the medical vaseline and the traditional Chinese medicine fine powder is 450-520: 40-70: when the proportion is 200-300 ℃, the phase transition temperature range of the traditional Chinese medicine wax moxibustion phase transition paste can be controlled within the range of 40-45 ℃ and does not include 45 ℃.
Evaluation test of greasy feeling effect
Based on the test protocol of example 3, the protocol containing fine powders of 0 part (comparative example 7), 2 parts (comparative example 8), 5 parts (example 3), and 10 parts (example 3a) of radix Angelicae Dahuricae was compared with commercially available wax moxibustion ointment A and wax moxibustion ointment B. In the test, 9 adult women (with the age of 30-40 years) were randomly selected in the outpatient service process, and divided into A, B, C groups, wherein each group was divided into three groups (respectively numbered A1, A2 and A3; B1, B2, B3; C1, C2 and C3), and the manufactured products of comparative example 7, comparative example 8, example 3 and example 3a were experienced, and the greasy feeling was subjectively scored, and the subjective feeling of greasy feeling was divided into four levels (0 point represents no greasy feeling, 1 point represents weak greasy feeling, 2 point represents strong greasy feeling, 3 point represents strong greasy feeling), and the subjective scores of the persons on the greasy feeling of the wax moxibustion-applied phase change cream were detailed, and the results are shown in Table 2.
TABLE 2 subjective perception of greasiness
Figure BDA0003696220230000062
As can be seen from the scoring results in Table 2, the addition of a proper amount of radix Angelicae Dahuricae powder (5-10 parts) to the wax moxibustion phase transition paste can significantly improve the greasy feeling of the wax moxibustion paste on the skin after use, and improve the comfort of the patient. Compared with the existing wax moxibustion paste on the market, the invention obviously controls the greasy feeling of the human skin after improving the formula. Although the radix angelicae can improve the greasiness of the wax moxibustion phase-change cream, the dosage of the radix angelicae cannot be too much, otherwise the self-leveling performance of the wax moxibustion phase-change cream can be seriously influenced, when the wax moxibustion phase-change cream is poured on a preservative film and is spread, the cream body is easily solidified too fast, and the spreading operation is troublesome.
Repeated cycle use test
750G of the traditional Chinese medicine wax moxibustion phase change ointment obtained in example 3 is compared with 750G of two traditional Chinese medicine wax moxibustion ointments (A and B) of certain brands purchased on the market, the traditional Chinese medicine wax moxibustion phase change ointment obtained in example 3, the brand A and the brand B are respectively heated for 5 minutes in a microwave oven, after the ointment is cooled and solidified, the microwave oven is heated for 5 minutes, the cycle is repeated, the hardness performance of the ointment after each standing, cooling and solidification is recorded (the hardness performance is measured by measuring the penetration of the product, the lower the penetration is, the higher the hardness is, the poorer the plasticity is, the measuring method can refer to GB/T4985-Petroleum penetration tester, the domestic SYD-2801G penetration tester is used for measuring, the instrument resolution is 0.01mm in the test), the medicine taste performance (the smell of an experimenter is used for evaluation, the medicine taste performance is divided into none, light, thick and thick 5 levels), the uniformity is observed by the experimenter, when the color difference between the upper part and the lower part of the condensed wax moxibustion paste body is obvious, the uniformity of the medicinal powder and the wax base is not good, the test result can be represented by 3 levels of no difference, slight layering and obvious layering), and the medicinal flavor performance and the uniformity of each treatment are recorded after each condensation, as shown in table 3. Note: the penetration degrees of the medical paraffin and the medical vaseline used in the test are 14.647mm and 201.548mm respectively.
TABLE 3 presentation of penetration, drug taste and uniformity
Figure BDA0003696220230000071
Figure BDA0003696220230000081
As can be seen from Table 3, the condensed penetration degree of the traditional Chinese medicine wax moxibustion phase change ointment prepared by the invention is obviously increased due to the addition of medical vaseline, and is higher than that of the traditional Chinese medicine wax moxibustion ointment with single paraffin base on the market, which shows that the plasticity of the traditional Chinese medicine wax moxibustion phase change ointment is greatly improved compared with the existing product, and the traditional Chinese medicine wax moxibustion phase change ointment has better fit with the human body curve when in use. Although the medicine flavor is obviously reduced after the medicine is recycled for 15 times, the requirement of repeated use is basically met, the medicine flavor release is not only related to the matrix, but also related to the formula of the traditional Chinese medicine fine powder, the dosage formula of the brand A and the brand B is not clear, the difference exists for the improved diseases, and the integral effect is considered to be good if the brand B medicine flavor still has larger medicine flavor after being recycled for multiple times. In the aspect of uniformity of the wax moxibustion paste, compared with the layering phenomenon of brand A and brand B, the wax block which is repeatedly used for 10 times has almost no layering phenomenon, and can be obviously layered after being circularly used for 15 times, so that the uniformity of the wax moxibustion paste is better than that of the existing wax moxibustion paste on the market.
The test results in table 3 show that the penetration of a single paraffin-based traditional Chinese medicine wax moxibustion ointment is slightly reduced after multiple cycles, but after 15 cycles of cyclic use, the penetration of the traditional Chinese medicine wax moxibustion phase-change ointment in the invention is still higher than that of the existing commercial wax moxibustion ointment, which indicates that the hardness of the traditional Chinese medicine wax moxibustion phase-change ointment in the invention is lower than that of the single paraffin-based wax moxibustion ointment, but with the increase of the cyclic heating times, the low melting point and volatile components in the phase-change ointment are more and more lost along with heating, so that the high melting point wax and the volatile components are enriched, and the penetration is obviously reduced after a certain number of cycles. In order to ensure the product quality and the curative effect on patients in clinical use, the invention can select 10 times of recycling as the waste judgment standard by combining the consideration of the penetration degree, the medicinal flavor factors and the layering phenomenon. The waste traditional Chinese medicine wax moxibustion phase change paste can be recycled as a common wax therapy using material, or can be used again after being further supplemented with traditional Chinese medicine fine powder.
It should be understood that although the present specification has been described in terms of embodiments, such descriptions are for clarity only and those skilled in the art will understand that the present specification as a whole may form other embodiments that will be apparent to those skilled in the art and also fall within the scope of the present invention.

Claims (4)

1. A traditional Chinese medicine wax moxibustion phase change paste is characterized in that: the Chinese medicinal wax moxibustion phase-change ointment comprises medical paraffin, medical vaseline and Chinese medicinal fine powder.
2. The traditional Chinese medicine wax moxibustion phase change paste as claimed in claim 1, which is characterized in that: the traditional Chinese medicine wax moxibustion phase change ointment comprises, by weight, 520 parts of medical paraffin wax, 40-70 parts of medical vaseline and 300 parts of 200-one powder, wherein each part of the traditional Chinese medicine powder comprises 10-20 parts of radix angelicae pubescentis, 25-30 parts of parasitic loranthus, 10-20 parts of eucommia ulmoides, 15-25 parts of radix cyathulae, 8-12 parts of frankincense, 8-14 parts of myrrh, 25-30 parts of rheum officinale, 3-8 parts of pericarpium zanthoxyli, 3-6 parts of borneol, 4-5 parts of fennel, 8-10 parts of pericarpium citri reticulatae viride, 10-15 parts of rhizoma corydalis, 15-20 parts of ground beeltle, 25-35 parts of lycopodium clavatum, 20-35 parts of caulis spatholobi and 5-10 parts of radix angelicae.
3. The preparation method of the traditional Chinese medicine wax moxibustion phase change paste according to claim 2, which is characterized by comprising the following steps:
(1) weighing 10-20 parts of radix angelicae pubescentis, 25-30 parts of parasitic loranthus, 10-20 parts of eucommia ulmoides, 15-25 parts of medicinal cyathula root, 8-12 parts of frankincense, 8-14 parts of myrrh, 25-30 parts of rheum officinale, 3-8 parts of pericarpium zanthoxyli, 3-6 parts of borneol, 4-5 parts of fennel, 8-10 parts of pericarpium citri reticulatae viride, 10-15 parts of rhizoma corydalis, 15-20 parts of ground beeltle, 25-35 parts of lycopodium clavatum, 20-35 parts of caulis spatholobi and 5-10 parts of radix angelicae, crushing into 200-mesh fine powder, and uniformly mixing for later use;
(2) and then heating and melting the medical paraffin to liquid state, adding the medical vaseline, continuously stirring until the medical paraffin is completely melted and uniformly mixed, adding the traditional Chinese medicine fine powder prepared in advance in the step (1), uniformly stirring, continuously heating until the traditional Chinese medicine fine powder is completely melted into thin paste, pouring the thin paste into a clean container with a cover, sealing and storing at normal temperature.
4. The use method of the traditional Chinese medicine wax moxibustion phase change paste according to claim 2 is characterized by comprising the following steps:
1) putting the traditional Chinese medicine wax moxibustion phase change paste into a microwave oven, and heating for 5 minutes to melt the paste into flowable thin paste again;
2) slowly pouring the thin pasty traditional Chinese medicine wax moxibustion phase change paste obtained in the step 1) onto a preservative film to enable the paste to automatically flow and spread into a thin cake shape, standing and cooling, covering a layer of mulberry paper after the surface of the thin pasty traditional Chinese medicine wax moxibustion paste loses luster and does not flow, and then closely attaching one side of the mulberry paper of the traditional Chinese medicine wax moxibustion phase change paste to the skin of a certain part of a human body;
3) then, covering clothes on the preservative film or applying a heat preservation bag, removing the traditional Chinese medicine wax moxibustion phase change cream after the heat felt by the human body is dissipated, and hardening the traditional Chinese medicine wax moxibustion phase change cream into a thin cake which is fit with the curve of the human body part;
4) cutting the traditional Chinese medicine wax moxibustion phase change paste obtained in the step 3) into small pieces, putting the small pieces into a clean container with a cover, sealing and storing at normal temperature for the next use.
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