CN113559204A - Honeyed pill for treating seborrheic alopecia and alopecia areata and preparation method thereof - Google Patents

Honeyed pill for treating seborrheic alopecia and alopecia areata and preparation method thereof Download PDF

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Publication number
CN113559204A
CN113559204A CN202111074206.5A CN202111074206A CN113559204A CN 113559204 A CN113559204 A CN 113559204A CN 202111074206 A CN202111074206 A CN 202111074206A CN 113559204 A CN113559204 A CN 113559204A
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Prior art keywords
parts
alopecia
root
honeyed pill
honey
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张征
康丽
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Yulin Traditional Chinese Medicine Hospital
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Yulin Traditional Chinese Medicine Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia

Abstract

The invention relates to the technical field of medicines, in particular to a honeyed pill for treating seborrheic alopecia and alopecia areata, which is mainly prepared from the following components in parts by weight: 30-50 parts of gastrodia elata; 20-30 parts of notopterygium root; 60-100 parts of prepared rhizome of rehmannia; 20-50 parts of red peony root; 60-100 parts of semen cuscutae; 20-30 parts of eucommia ulmoides; 20-50 parts of teasel roots; 60-100 parts of Chinese yam; 60-100 parts of fleece-flower root; 20-30 parts of glossy privet fruit. The invention starts from nourishing liver and kidney, replenishing essence and growing hair, and can effectively treat seborrheic alopecia and alopecia areata. Compared with the Chinese patent medicine for treating alopecia sold on the market at present, the Chinese patent medicine for treating alopecia has the advantages of convenience in taking, exact curative effect, convenience in popularization and the like, and is suitable for popularization and application in a large range.

Description

Honeyed pill for treating seborrheic alopecia and alopecia areata and preparation method thereof
Technical Field
The invention relates to the technical field of medicines, and in particular relates to a honeyed pill for treating seborrheic alopecia and alopecia areata and a preparation method thereof.
Background
Seborrheic alopecia and alopecia areata have certain universality and certain harmfulness. Clinical data show that: 30% of patients have a severe depression tendency and 90% of patients apparently feel self-distrust. Therefore, from this group of data, it is imperative to stop hair loss and grow hair. Alopecia is described in the "internal classic" as: the clinical observation of "Fall abortion" can be seen in many diseases, but there are also independent ones, which are difficult to distinguish the reasons why the lung governs the skin and hair, and the kidney governs the essence, which is prosperous and erupting in hair, and these can indicate that alopecia is connected with the functional changes of some viscera. Clinically, alopecia is characterized by sudden onset of alopecia, circular or elliptical alopecia and no subjective symptom of bright scalp, which is called alopecia areata, and generally caused by mental stimulation, emotional disturbance, hyperactivity of heart-fire, blood heat generating wind and wind-driven alopecia, and the alopecia is suitable for cooling blood, clearing heat and tonifying qi. Also, the scalp has more grease, scurf, scalp itch and thin and sparse whole scalp hair, which is the deficiency of both qi and blood and yin deficiency and blood heat, and is suitable for tonifying qi and blood, nourishing yin and clearing heat at any age.
At present, no traditional Chinese medicine honeyed pill can treat seborrheic alopecia and alopecia areata. Therefore, how to provide a honeyed pill for treating seborrheic alopecia and alopecia areata and a preparation method thereof become a long-term technical demand of the technical personnel in the field.
Disclosure of Invention
In order to solve the problems, the invention provides the honeyed pill for treating the seborrheic alopecia and the alopecia areata and the preparation method thereof, which starts with nourishing liver and kidney and replenishing essence to grow hair and can effectively treat the seborrheic alopecia and the alopecia areata.
In order to achieve the purpose, the invention adopts the technical scheme that: a honeyed pill for treating seborrheic alopecia and alopecia areata is mainly prepared from the following components in parts by weight: 30-50 parts of gastrodia elata; 20-30 parts of notopterygium root; 60-100 parts of prepared rhizome of rehmannia; 20-50 parts of red peony root; 60-100 parts of semen cuscutae; 20-30 parts of eucommia ulmoides; 20-50 parts of teasel roots; 60-100 parts of Chinese yam; 60-100 parts of fleece-flower root; 20-30 parts of glossy privet fruit.
Further, the gastrodia elata is rhizoma gastrodiae, the eucommia ulmoides is salted eucommia ulmoides, and the polygonum multiflorum is prepared polygonum multiflorum.
Further, the composition is mainly prepared from the following components: 50g of gastrodia elata, 30g of notopterygium root, 100g of prepared rehmannia root, 50g of red paeony root, 100g of dodder, 30g of eucommia ulmoides, 50g of teasel root, 100g of Chinese yam, 100g of fleece-flower root and 30g of glossy privet fruit.
The invention also provides a preparation method of the honeyed pill for treating seborrheic alopecia and alopecia areata, which comprises the following steps:
s1, weighing the components in parts by weight;
s2, mixing rhizoma Gastrodiae, rhizoma Et radix Notopterygii, radix rehmanniae Preparata, radix Paeoniae Rubra, semen Cuscutae, cortex Eucommiae, radix Dipsaci, rhizoma Dioscoreae, radix Polygoni Multiflori, and fructus Ligustri Lucidi, micronizing to 100 mesh, mixing the fine powder with Mel, and making into honeyed pill.
Further, the ratio of the fine powder to the honey is 1: 0.9-1.5, wherein the honey is refined honey.
Further, the diameter of the honeyed pill is 8-10 mm.
The invention has the following beneficial effects: starting from 'nourishing liver and kidney, replenishing essence and growing hair', the traditional Chinese medicine can effectively treat seborrheic alopecia and alopecia areata, has the effects of calming endogenous wind and arresting convulsion, clearing and activating the channels and collaterals, relieving exterior cold and dispelling wind and dampness, has the effects of nourishing yin and tonifying kidney, has the effects of clearing away heat and cooling blood and removing blood stasis, has the effects of tonifying liver and kidney and strengthening essence, has the effects of tonifying liver and kidney, tonifying kidney and regulating blood vessels, warming kidney and supporting yang, warming spleen and stopping diarrhea, has the effects of tonifying spleen and stomach, tonifying kidney and strengthening essence, tonifying liver and kidney, tonifying essence and blood, blackening beard and hair, nourishing liver and kidney and blackening hair and improving eyesight. The medicines have the effects of nourishing liver and kidney, replenishing essence and promoting hair growth. Compared with the Chinese patent medicine for treating alopecia sold on the market at present, the Chinese patent medicine for treating alopecia has the advantages of convenience in taking, exact curative effect, convenience in popularization and the like, and is suitable for popularization and application in a large range.
The honeyed pill is prepared with refined honey as adhesive, and has the functions of moistening lung, relieving cough, relaxing bowels, nourishing middle warmer, moistening dryness, etc. and is suitable for children to take.
Detailed Description
In order that the objects and advantages of the invention will be more clearly understood, the invention is further described in detail below with reference to examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A honeyed pill for treating seborrheic alopecia and alopecia areata is prepared by the following steps:
s1, weighing: 50g of gastrodia elata, 30g of notopterygium root, 100g of prepared rehmannia root, 50g of red paeony root, 100g of dodder, 30g of eucommia ulmoides, 50g of teasel root, 100g of Chinese yam, 100g of fleece-flower root and 30g of glossy privet fruit;
s2, crushing: mixing rhizoma Gastrodiae, Notopterygii rhizoma, radix rehmanniae Preparata, radix Paeoniae Rubra, semen Cuscutae, Eucommiae cortex, radix Dipsaci, rhizoma Dioscoreae, Polygoni Multiflori radix and fructus Ligustri Lucidi, micronizing to 100 mesh to obtain medicinal powder, and placing in a sterilizing basin;
s3, secret matching: preparing honey (such as 500g of medicinal powder and 450-750 g of honey) according to the weight ratio of 1: 0.9-1.5;
s4, refining honey: the purpose of refining honey is to remove impurities, destroy enzymes, kill bacteria, evaporate water and enhance viscosity. Selecting Chinese honey, boiling with strong fire when refining the honey, then slowly decocting with slow fire, meanwhile placing a bowl of cold water beside, dipping a drop of honey with bamboo chopsticks when the honey is yellow and foamy, dropping the honey into the cold water, and if the honey is not dispersed in the water and sinks to the bottom (namely, dropping water to form beads), finishing refining the honey, wherein about 800g of refined honey can be obtained from 1000g of honey, and about 1200g of refined honey needs to be used from 1000g of Chinese medicinal powder;
s5, mixing and blending drugs: pouring the boiled honey into the medicinal powder contained in the disinfection basin by using a spoon, stirring the medicinal powder while pouring the honey, stopping adding the honey when dry medicinal powder is basically not seen (the honey cannot be added too much, and more honey is added, so that pills are not easy to form), and after the honey is mixed, kneading the medicinal powder and the honey into a dough in the disinfection basin;
s6, and pill: in order to prevent the medicinal mass from sticking hands or sticking a device, a small amount of glycerin, sesame oil or peanut oil and the like can be dripped into the palm during pill mixing, so that the medicinal pill is not easy to stick, and the pill can be smooth and bright, and the diameter of the honeyed pill is 8-10 mm;
s7, packaging and storing: the prepared honeyed pill has round and smooth appearance, compact and moist surface, no visible fiber or other abnormal color points, and can be packaged with wax paper, cellophane, plastic bag or wax shell, and stored in dry place.
The taking method comprises the following steps: it is administered 2 times per day, 1 granule each time.
The invention starts from the prescription of nourishing liver and kidney, replenishing essence and growing hair, has obvious effect on seborrheic alopecia and alopecia areata, and compared with the existing Chinese patent medicine for treating alopecia sold on the market, the honeyed pill has the advantages of convenient taking, definite curative effect, convenient popularization and the like, and is suitable for wide popularization and application. Adds new means and method for treating the patients with seborrheic alopecia and alopecia areata, and improves the life quality.
Clinical data
100 diagnosed seborrheic alopecia and alopecia areata patients are collected, and honeyed pills prepared by the invention are added on the basis of general treatment for oral administration. The clinical curative effect and the drug safety are evaluated according to the set observation indexes before and after the drug is taken, so that the clinical curative effect of the invention is further researched and verified.
The specific treatment scheme is as follows:
oral administration: the preparation is administered with warm water 2 times per day, 1 granule each time, and the effect is detected for 30-60 days
The therapeutic effect judgment standard is as follows: the method has the following advantages: reduced head oil, reduced dandruff, and hair growth
And (4) invalidation: the symptoms are not improved basically after the medicine is continuously taken for more than 60 days
As a result: 96 cases are cured, 4 cases are invalid.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.

Claims (6)

1. The honeyed pill for treating seborrheic alopecia and alopecia areata is characterized by being mainly prepared from the following components in parts by weight: 30-50 parts of gastrodia elata; 20-30 parts of notopterygium root; 60-100 parts of prepared rhizome of rehmannia; 20-50 parts of red peony root; 60-100 parts of semen cuscutae; 20-30 parts of eucommia ulmoides; 20-50 parts of teasel roots; 60-100 parts of Chinese yam; 60-100 parts of fleece-flower root; 20-30 parts of glossy privet fruit.
2. The honeyed pill for the treatment of seborrheic alopecia and alopecia areata of claim 1, wherein the rhizoma Gastrodiae is rhizoma Gastrodiae, the fructus Chaenomelis is fructus Chaenomelis, cortex Eucommiae is cortex Eucommiae, and radix Polygoni Multiflori Preparata is radix Polygoni Multiflori Preparata.
3. The honeyed pill for the treatment of seborrheic alopecia and alopecia areata as claimed in claim 1, which is prepared from the following components: 50g of gastrodia elata, 30g of notopterygium root, 100g of prepared rehmannia root, 50g of red paeony root, 100g of dodder, 30g of eucommia ulmoides, 50g of teasel root, 100g of Chinese yam, 100g of fleece-flower root and 30g of glossy privet fruit.
4. The preparation method of the honeyed pill for treating seborrheic alopecia and alopecia areata as claimed in claim 1, which comprises the following steps:
s1, weighing the components in parts by weight;
s2, mixing rhizoma Gastrodiae, rhizoma Et radix Notopterygii, radix rehmanniae Preparata, radix Paeoniae Rubra, semen Cuscutae, cortex Eucommiae, radix Dipsaci, rhizoma Dioscoreae, radix Polygoni Multiflori, and fructus Ligustri Lucidi, micronizing to 100 mesh, mixing the fine powder with Mel, and making into honeyed pill.
5. The preparation method of claim 4, wherein the ratio of the fine powder to the honey is 1: 0.9-1.5, wherein the honey is refined honey.
6. The preparation method according to claim 4, wherein the diameter of the honeyed pill is 8-10 mm.
CN202111074206.5A 2021-09-14 2021-09-14 Honeyed pill for treating seborrheic alopecia and alopecia areata and preparation method thereof Pending CN113559204A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106549A (en) * 2015-09-30 2015-12-02 成都倍加特生物科技有限公司 Oral traditional Chinese medicine pill for treating phalacrosis and preparation method of oral traditional Chinese medicine pill
CN105943886A (en) * 2016-06-08 2016-09-21 晏小明 Traditional Chinese medicine composition capsules for nourishing blood and growing hair and preparation method thereof
CN110538258A (en) * 2019-09-12 2019-12-06 郭运山 traditional Chinese medicine formula for treating alopecia and leukotrichia and preparation method thereof
CN111419989A (en) * 2020-04-27 2020-07-17 山东马加润丝生物科技有限公司 Formula and preparation method of honeyed pills for nourishing blood and growing hair

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106549A (en) * 2015-09-30 2015-12-02 成都倍加特生物科技有限公司 Oral traditional Chinese medicine pill for treating phalacrosis and preparation method of oral traditional Chinese medicine pill
CN105943886A (en) * 2016-06-08 2016-09-21 晏小明 Traditional Chinese medicine composition capsules for nourishing blood and growing hair and preparation method thereof
CN110538258A (en) * 2019-09-12 2019-12-06 郭运山 traditional Chinese medicine formula for treating alopecia and leukotrichia and preparation method thereof
CN111419989A (en) * 2020-04-27 2020-07-17 山东马加润丝生物科技有限公司 Formula and preparation method of honeyed pills for nourishing blood and growing hair

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Title
苏路侠等: "生发汤治脱发", 《山东医药工业》 *
陈淡峰: "神应养真汤治疗秃发30例", 《湖北中医杂志》 *

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Application publication date: 20211029