CN115381921B - Traditional Chinese medicine composition and medicinal wax for treating knee osteoarthritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition and medicinal wax for treating knee osteoarthritis and preparation method thereof Download PDFInfo
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- CN115381921B CN115381921B CN202211030109.0A CN202211030109A CN115381921B CN 115381921 B CN115381921 B CN 115381921B CN 202211030109 A CN202211030109 A CN 202211030109A CN 115381921 B CN115381921 B CN 115381921B
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Abstract
The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine composition and medicinal wax for treating knee osteoarthritis and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 2-4 parts of pericarpium zanthoxyli, 2-4 parts of fennel, 2-4 parts of garden balsam stem, 2-4 parts of radix clematidis, 2-4 parts of Chinese honeylocust fruit, 1-3 parts of rhizoma corydalis, 1-3 parts of ligusticum wallichii, 1-3 parts of radix angelicae pubescentis, 1-3 parts of dried ginger, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh. The composition can obviously relieve joint pain of patients, improve life quality of patients, and has a clinical effective rate of 86%; the medical wax prepared by mixing the medical wax is simple to prepare, sanitary and safe, and has low price.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine composition and medicinal wax for treating knee osteoarthritis and a preparation method thereof.
Background
Knee osteoarthritis is a common clinical chronic disease, and the pathological changes mainly comprise knee cartilage degeneration, subchondral ossification and synovitis, and the main clinical manifestations are knee joint swelling, pain and stiffness, and the severe cases can lead to knee joint varus and valgus deformity to cause walking disorder. At present, the pathogenesis of knee osteoarthritis is not completely defined, is considered to be caused by the interaction of mechanical factors and biological factors, is related to factors such as inflammatory infiltration, estrogen deficiency, cytokine synthesis, metabolic disorder and the like, and belongs to the categories of knee arthralgia, bone paralysis and the like in traditional Chinese medicine. The disease is the pattern of the deficiency and excess, and the traditional Chinese medicine considers that liver governs tendons and kidneys govern bones, such as liver and kidneys are full, so that tendons and bones are strong, joints are smooth, and movement is flexible. The viscera of the middle-aged and the elderly gradually decline in yin and yang qi and blood, yang deficiency cannot warm up meridians, qi deficiency cannot care meridians, qi and blood circulation is weak, and the meridians are easy to be affected by cold and dampness; or the deficiency of yang qi in the body caused by the damage of yang qi in cold-damp environment, the warming and pushing actions of the yang qi are lost, and the meridians of the human body are affected by cold evil to lead to stagnation, so that qi and blood flow are not smooth, and pain is caused by the obstruction.
The disease is counted to be better developed in middle-aged and elderly patients, women are higher than men, the incidence rate of people over 45 years old reaches 13.8%, and the incidence rate of obese patients is higher. At present, knee osteoarthritis is one of the main burdens of the current medical treatment and economy, no thorough cure method for the disease is available in clinic, and serious patients can be disabled along with the development of the disease.
Therefore, there is a great need for a medicament for treating knee osteoarthritis.
Disclosure of Invention
Aiming at the problems, the invention aims to provide the traditional Chinese medicine composition for treating knee osteoarthritis, which can obviously relieve joint pain of patients, improve life quality of the patients and has a clinical effective rate of up to 86%.
In order to achieve the above object, the following technical scheme may be adopted:
the invention provides a traditional Chinese medicine composition for treating knee osteoarthritis, which comprises, by weight, 2-4 parts of pericarpium zanthoxyli, 2-4 parts of fennel, 2-4 parts of garden balsam stem, 2-4 parts of radix clematidis, 2-4 parts of Chinese honeylocust, 1-3 parts of rhizoma corydalis, 1-3 parts of ligusticum wallichii, 1-3 parts of radix angelicae pubescentis, 1-3 parts of dried ginger, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh.
The invention also provides a medicinal wax for treating knee osteoarthritis, which comprises, by mass, 440-460 parts of medical white wax, 90-110 parts of Vaseline, 120-180 parts of water and a traditional Chinese medicine composition for treating knee osteoarthritis.
In still another aspect, the present invention provides a method for preparing the above medicinal wax for treating knee osteoarthritis, which comprises: mixing Cera chinensis, vaseline and water, heating to melt, mixing with the Chinese medicinal composition for treating knee osteoarthritis, and cooling to obtain medicinal wax for treating knee osteoarthritis.
The beneficial effects of the invention at least comprise:
(1) The composition for treating knee osteoarthritis provided by the invention can obviously relieve joint pain of patients, improve life quality of patients and achieve a clinical effective rate of 86%;
(2) The medicinal wax for treating knee osteoarthritis is simple to prepare, sanitary and safe and low in cost.
Detailed Description
The examples are presented for better illustration of the invention, but the invention is not limited to the examples. Those skilled in the art will appreciate that various modifications and adaptations of the embodiments described above are possible in light of the above teachings and are intended to be within the scope of the invention.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. Unless the context clearly differs, singular forms of expression include plural forms of expression. As used herein, it is understood that terms such as "comprising," "having," "including," and the like are intended to indicate the presence of a feature, number, operation, component, part, element, material, or combination. The terms of the present invention are disclosed in the specification and are not intended to exclude the possibility that one or more other features, numbers, operations, components, elements, materials or combinations thereof may be present or added. As used herein, "/" may be interpreted as "and" or "as appropriate.
The embodiment of the invention provides a traditional Chinese medicine composition for treating knee osteoarthritis, which comprises, by weight, 2-4 parts of pericarpium zanthoxyli, 2-4 parts of fennel, 2-4 parts of garden balsam stem, 2-4 parts of radix clematidis, 2-4 parts of Chinese honeylocust fruit, 1-3 parts of rhizoma corydalis, 1-3 parts of ligusticum wallichii, 1-3 parts of radix angelicae pubescentis, 1-3 parts of dried ginger, 0.5-1.5 parts of frankincense and 0.5-1.5 parts of myrrh.
In some embodiments, the above traditional Chinese medicine composition for treating knee osteoarthritis comprises, by weight, 3 parts of pericarpium zanthoxyli, 3 parts of fructus Foeniculi, 3 parts of herba speranskiae tuberculatae, 3 parts of radix Clematidis, 3 parts of fructus gleditsiae, 2 parts of rhizoma corydalis, 2 parts of rhizoma Chuanxiong, 2 parts of radix angelicae pubescentis, 2 parts of rhizoma zingiberis, 1 part of Olibanum, and 1 part of myrrha.
In the traditional Chinese medicine composition for treating knee osteoarthritis, the radix angelicae pubescentis removes long-term arthralgia, and removes pathogenic wind-cold-dampness between lower jiao and bones and muscles; radix Clematidis, herba Speranskiae Tuberculatae, and caulis et folium Gaultheriae Yunnanensis for dispelling pathogenic wind and dampness and dredging channels and collaterals; the compatibility of the pericarpium zanthoxyli, the fennel and the dried ginger plays roles in warming channels, dispelling cold and relieving pain; fructus Gleditsiae Abnormalis and radix scrophulariae Hu Xiaozhong can relieve pain, and rhizoma Ligustici Chuanxiong, olibanum and Myrrha can promote blood circulation, remove meridian obstruction and relieve arthralgia; the Chinese medicinal composition has effects of warming channels, dispelling cold, relieving swelling and pain; in addition, the radix angelicae pubescentis can reduce the secretion of inflammatory medium IL-1 in synovial fluid to relieve synovitis, promote the secretion of TGF-beta to relieve the damage of chondrocytes; both the clematis root and the garden balsam stem have obvious analgesic and anti-inflammatory effects.
The invention further provides a medicinal wax for treating knee osteoarthritis, which comprises, by mass, 440-460 parts of medical white wax, 90-110 parts of Vaseline, 120-180 parts of water and a traditional Chinese medicine composition for treating knee osteoarthritis. It should be noted that, the above-mentioned traditional Chinese medicine composition for treating knee osteoarthritis may be a traditional Chinese medicine composition known in the art, and preferably the traditional Chinese medicine composition for treating knee osteoarthritis provided by the invention, namely, the above-mentioned traditional Chinese medicine composition for treating knee osteoarthritis.
In some implementations, the above medicinal wax for treating knee osteoarthritis comprises, by mass, 450 parts of medical white wax, 100 parts of vaseline, 150 parts of water, and a traditional Chinese medicine composition for treating knee osteoarthritis.
Another embodiment of the present invention provides a method for preparing the above medicinal wax for treating knee osteoarthritis, comprising: mixing Cera chinensis, vaseline and water, heating to melt, mixing with the Chinese medicinal composition for treating knee osteoarthritis, and cooling to obtain medicinal wax for treating knee osteoarthritis. The purpose of the heating and melting is to form paste, which is convenient to mix with the traditional Chinese medicine composition powder. Likewise, the traditional Chinese medicine composition for treating knee osteoarthritis in the preparation method can be a traditional Chinese medicine composition known in the art, and preferably the traditional Chinese medicine composition for treating knee osteoarthritis provided by the invention, namely the traditional Chinese medicine composition for treating knee osteoarthritis.
The traditional Chinese medicine has abundant clinical experience accumulated in internal and external therapies for treating knee osteoarthritis, such as traditional Chinese medicine smearing, wax therapy, acupoint application, traditional Chinese medicine fumigation and the like, and has good clinical curative effects. In 2001 edition of "diagnosis and treatment guidelines for osteoarthritis" it is indicated that a local external treatment method is firstly recommended for knee osteoarthritis treatment, and a wax treatment method is recorded in Sunshiji Qianjiading Fang, wherein it is mentioned that the dislocation of the mandibular joint is treated by the wax treatment method after the manual reduction, so that the reduction of the joint can be promoted. The wax therapy has wide clinical application and good effect of treating knee osteoarthritis. The simple medical paraffin has the warm effect after being heated and dissolved, can dilate local capillary vessels, promote blood circulation to increase capillary vessel permeability, accelerate epithelial cell growth to make local exudation and absorption, and is beneficial to tissue regeneration and repair. Specifically, the paraffin is continuously reduced in volume in the cooling process, and the generated local mechanical compression effect can prevent lymphatic fluid and blood in tissues from exuding, lighten tissue edema, be closely contacted with skin, and can transfer heat to deep tissues to play roles in diminishing inflammation, spasmolysis and pain relief.
It should be noted that, the traditional Chinese medicine wax therapy is a traditional Chinese medicine special therapy combining traditional therapy and modern technology based on the guidance of traditional Chinese medicine theory, wherein the traditional Chinese medicine wax therapy combines the traditional Chinese medicine package formed by flexible addition and subtraction of traditional Chinese medicine with medical paraffin for application, and is externally applied to the affected part to play roles of activating blood circulation to dissipate blood stasis, eliminating dampness and cold, warming and dredging channels and collaterals. In addition, the product can be combined with the warm effect and mechanical compression effect of paraffin, so that the two treatment factors of traditional Chinese medicine and wax therapy are mutually enhanced to treat knee osteoarthritis. In a word, the Chinese medicine wax therapy integrates percutaneous absorption, acupoint stimulation, thermotherapy and the like, has rapid, simple and convenient effect, low cost, safety and small toxic and side effects, and is a measure commonly used for treating painful diseases in rehabilitation, pain and rheumatism.
In addition, the clinical traditional Chinese medicine wax therapy adopts the traditional Chinese medicine and medical wax separation technology, the manufacturing of the medical wax is provided with a full-automatic wax manufacturing machine, the cost is high, the temperature of the wax block is not easy to master, the wax block is required to be disinfected repeatedly and then used, and the operation is complex. The traditional Chinese medicine composition for treating knee osteoarthritis is uniformly mixed with the medical wax, so that the traditional Chinese medicine composition is simple in preparation, sanitary, safe and low in cost, and one person can use the traditional Chinese medicine composition for treating knee osteoarthritis; in addition, clinical efficacy evaluation shows that the medicinal wax can obviously relieve joint pain of patients, improve life quality of the patients and achieve a clinical effective rate of 86%.
When the medicinal wax for treating knee osteoarthritis is used, the Chinese medicaments and the medicinal wax can be directly contacted with the skin of an affected part, so that the operation is simple and the grasping is convenient; the Chinese medicinal composition has the advantages of not affecting the curative effect of the Chinese medicaments, not affecting the thermal therapy effect and the mechanical effect of the wax, guaranteeing the balance of the medicament at the affected part and enhancing the curative effect of the local treatment of the Chinese medicaments and the wax; moreover, the operation flow method is simple, convenient, effective and cheap, and improves the satisfaction degree of patients.
For a better understanding of the present invention, the content of the present invention is further elucidated below in connection with the specific examples, but the content of the present invention is not limited to the examples below.
1. Preparation of cerate
EXAMPLE 1 preparation of traditional Chinese medicine wax extract
Taking 3 parts of pericarpium zanthoxyli, 3 parts of fennel, 3 parts of garden balsam stem, 3 parts of radix clematidis, 3 parts of Chinese honeylocust fruit, 2 parts of rhizoma corydalis, 2 parts of szechuan lovage rhizome, 2 parts of radix angelicae pubescentis, 2 parts of dried ginger, 1 part of frankincense and 1 part of myrrh, and grinding into fine powder for standby; 450 g of medical white wax, 100 g of Vaseline and 150 ml of water are put into a special plastic microwave preservation box (bag cover) with the specification of 1200 ml, heated for 15 minutes by using a medium fire of a microwave oven, 250 g of medicinal powder is added after the white wax is melted, and the mixture is uniformly mixed and cooled to obtain the prepared traditional Chinese medicine cerate.
Comparative example 1 preparation of ordinary cerate
450 g of medical white wax, 100 g of Vaseline and 150 ml of water are taken to be put into a special plastic microwave preservation box (bag cover) with the specification of 1200 ml, the plastic microwave preservation box is heated for 15 minutes by using a medium fire of a microwave oven, and after the white wax is melted, edible coloring agent is added, evenly mixed and cooled, thus obtaining the prepared common cerate.
2. Verification of efficacy of cerate
In this validation experiment, the temperature was maintained in a treatment room at 24 ℃ -30 ℃; proper amount of warm boiled water is needed before and after the wax therapy, and the bath is not needed for 3-4 hours after the wax therapy, and cold air is not needed to be blown; the temperature of the wax is accurately controlled, the coating is uniform, the action medicine is rapid, and if the patient has pain, the patient should check immediately; after wax therapy, patients reflect skin discomfort, old wax must be completely discarded and replaced by new wax blocks; after the treatment is finished, the patient takes a rest for half an hour and then goes out of the door to prevent cold wind from being affected by cold; 1 time per day for about 30 minutes, 15 times for 1 treatment course, rest for 2 days between the treatment courses, and 2 treatment courses in total; the wax can be repeatedly used, and one person can use the wax in a box, and 20 times of optimal use are recommended, so that the optimal components of the wax and the traditional Chinese medicine can be exerted.
In the verification test, the patients are immediately checked after wax therapy for pain induction, and the treatment is stopped immediately when rash appears at the treatment part, so that symptoms are relieved; when the skin of the affected part is broken during wax therapy, a layer of vaseline gauze can be covered for treatment, and the local ulcer or wound is treated after washing by potassium permanganate solution and covering a thin wax film; small blisters appear in the part, patients can be ordered to protect the blisters, the blisters do not break, and the patients can heal after absorbing the blisters in 2 to 5 days. If the water bubble is large, the disinfection millineedle can be used for puncturing the water bubble and discharging water liquid, and the scald oil and the like are properly coated on the surface of the wound to keep the surface of the wound clean, and the wound can be healed in a plurality of days generally.
In the verification test, 100 cases of knee osteoarthritis patients from the first clinical hospital of Jilin province traditional Chinese medicine academy of sciences of Chinese medicine and the third affiliated hospital of Changchun traditional Chinese medicine university in 1 month to 2021 month were selected as study subjects. The treatment group and the control group were randomized into 50 cases. Treatment group 50, 16 men and 34 women; age at least 51 years, at most 77 years, mean (55.41 ±7.61) years; the average course of disease is 3.71+ -2.12 years. Control group 50, 18 men and 32 women; the ages are at least 50 years old, at most 74 years old, and the average (54.15+/-8.01) years old; the average course of disease is 3.82+ -1.91 years. Both groups of patients were not statistically significant (P > 0.05) for analysis in terms of sex, age, course of disease, etc. The study meets the ethical requirements of the declaration of Helsinki, ethical examination number: jlszkl 2020 reviews the word-016.
In this validation experiment, western diagnostic criteria: knee joint pain repeatedly occurs in approximately 1 month with reference to the department of orthopedics, and orthopedics, bone joint diagnosis and treatment guidelines (2007 edition) (1); (2) x-ray film (standing or weight bearing position) shows joint gap narrowing, subchondral bone sclerosis and/or cystic changes, joint margin osteophyte formation; (3) joint fluid (at least 2 times) clear, viscous, WBCs < 2000/ml; (4) patients age 40 years or older; (5) morning stiffness is less than 30 minutes; (6) the bone is rubbed during the activity; the knee osteoarthritis can be diagnosed by integrating clinical, laboratory and X-ray examination, and conforming to (1) + (2) or (1) + (3) + (5) + (6) or (1) + (4) + (5) + (6).
In the verification test, traditional Chinese medicine syndrome waiting diagnosis standard: the "guidelines for clinical study of new Chinese medicine" was formulated and issued by Ministry of health of China in 1993, with reference to "common medical expert of knee osteoarthritis" (2015 edition) [15] And (5) formulating. The Chinese medicine differentiation type: cold-dampness obstruction syndrome. Main symptoms are as follows: knee joint cold pain; soreness and heaviness of waist and knee; aggravate when it encounters cold, and get pain due to heat. Secondary symptoms: swelling of the joints; adverse flexing and stretching; local skin is not red and is not hot to touch; aversion to wind-cold. Tongue pulse: a pale red or purple tongue with thin, white or greasy coating, and a wiry, tight or deep, thin, astringent or soft pulse.
In the verification test, volunteers accord with early and middle stage knee osteoarthritis patients with the traditional Chinese and western medicine diagnosis standards, the ages are 45-80 years, the sexuality is unlimited, the volunteers participate in the test study, and the volunteers sign informed consent; volunteers do not belong to women in lactation and gestation, to allergic constitution patients, and to patients with serious primary diseases and mental diseases such as heart, brain, liver, kidney, hematopoietic system and endocrine system.
In the verification test, the curative effect judgment standard is as follows: pain assessment was scored using VAS, with a total score of 10 points, and a high score indicated that the patient had severe pain. Knee function scoring with Lysholm [18] The functions of supporting, squatting, knee softening, pain, claudication, twisting lock, swelling, going up and down stairs and the like of the patient are evaluated, the total score is 100 minutes, and the high score indicates that the knee joint function of the patient is good. The curative effect standard refers to the curative effect evaluation standard of the bone arthralgia in the traditional Chinese medicine disease diagnosis curative effect standard. And (3) curing: the calculated result is more than or equal to 90 percent, the joint pain disappears, and the swelling and the activity function and the physical sign completely disappear; the effect is shown: 90 percent of calculation results are more than or equal to 70 percent, the arthralgia disappears, and the swelling, the activity function and the physical sign are obviously reduced; the method is effective: 70 percent more than 30 percent of calculated results show that the arthralgia disappears and the swelling, the activity function and the physical sign are reduced; invalidation: the calculated result is less than 30% and the joint pain disappears, and the swelling, the activity function and the physical sign are not improved.
In the verification test, SPSS20.0 statistical software is adopted to conduct data processing analysis, the count data is expressed in terms of rate, and X is used 2 Checking and metering dataIt is statistically significant that P <0.05 is the difference by t-test.
Example 2 test verification
Putting a box of wax paste prepared in advance into a microwave oven, dissolving the medicinal wax to about 50-60 DEG (long-time high-temperature heating is not needed to avoid damaging the wax when the wax is dissolved) for 5 minutes by medium fire, taking out the medicinal wax, uniformly stirring the dissolved medicinal wax by a wooden shovel, and then coating the medicinal wax on the knee joint of a patient after the medicinal wax is stably reduced to 40-45 DEG (the temperature can be properly regulated according to different tolerance degrees of the patient and is based on the tolerance of the patient), wherein the thickness of the medicinal wax is about 1.5 cm; covering a disposable plastic film and a thick towel on the wax paste for heat preservation; the treatment group used the traditional Chinese medicine cerate prepared in example 1; the control group used the normal cerate prepared in comparative example 1. Both groups used basal treatment regimens: making diagnosis and treatment guidelines for osteoarthritis in 2010 with reference to the rheumatology division of the Chinese medical society; 1 time per day for about 30 minutes, and 10 times are 1 treatment course, and rest for 2 days between treatment courses for 2 treatment courses.
Judging the treatment course effect according to the treatment effect judgment standard, wherein the treatment course effect is specifically as follows:
(1) VAS score comparison for knee pain
The results of the VAS score comparison for knee pain are shown in Table 1 below, where the difference in scores of the two groups of patients before treatment was not statistically significant P >0.05, and the difference between the two groups was statistically significant P <0.05, after treatment, which was significantly lower than that before treatment.
Table 1 knee pain VAS scores (score,)
| group of | Before treatment | After treatment |
| Treatment group | 6.29±1.23# | 3.51±1.22*△ |
| Control group | 6.18±1.21 | 3.89±1.34* |
Note that: comparison of two groups before treatment, #p >0.05, comparison of two groups before and after treatment, #p <0.05, comparison of two groups after treatment, #p >0.05.
(2) Knee function Lyshlom score
The results of Lyshlom scoring of knee joint function are shown in table 2 below, where the difference in scores of the two groups of patients before treatment was not statistically significant P >0.05, the difference between the two groups of patients after treatment was significantly lower than before treatment, the difference was statistically significant P <0.05, and the comparison between the two groups of patients was superior to the control group P <0.05.
Table 2Lyshlom knee function scores (score,)
| group of | Before treatment | After treatment |
| Treatment group | 43.14±2.51# | 67.35±2.23*▲ |
| Control group | 42.72±2.04 | 47.48±2.61* |
Note that: comparison of two groups before treatment, #p >0.05, comparison of two groups before and after treatment, #p <0.05, comparison between two groups after treatment, #p <0.05.
(3) Comparison of clinical efficacy
The results of the clinical effect comparison are shown in the following table 3, the total effective rate of the treatment group is 86%, and the total effective rate of the control group is 70% higher than that of the control group (p < 0.05).
Table 3 comparative clinical efficacy of the two groups (%)
Note that: comparison of the two groups, p <0.05.
The following verification effects show that both the treatment group and the control group can obviously relieve joint pain of patients, improve the life quality of the patients, and have statistical significance in VAS score and Lysholm knee joint score before and after treatment; the clinical effective rate of the treatment group is 86%, the clinical effective rate of the control group is 70%, and the treatment group is superior to the control group in comparison between the two groups.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention.
Claims (3)
1. The medicinal wax for treating knee osteoarthritis is characterized by being prepared from 2-4 parts of pericarpium zanthoxyli, 2-4 parts of fennel, 2-4 parts of garden balsam stem, 2-4 parts of radix clematidis, 2-4 parts of Chinese honeylocust fruit, 1-3 parts of rhizoma corydalis, 1-3 parts of ligusticum wallichii, 1-3 parts of radix angelicae pubescentis, 1-3 parts of dried ginger, 0.5-1.5 parts of frankincense, 0.5-1.5 parts of myrrh, 440-460 parts of medical white wax, 90-110 parts of vaseline and 120-180 parts of water according to parts by weight.
2. The medicinal wax for treating knee osteoarthritis according to claim 1, wherein the medicinal wax is prepared from 3 parts by weight of pericarpium zanthoxyli, 3 parts by weight of fennel, 3 parts by weight of garden balsam stem, 3 parts by weight of radix clematidis, 3 parts by weight of Chinese honeylocust fruit, 2 parts by weight of rhizoma corydalis, 2 parts by weight of ligusticum wallichii, 2 parts by weight of radix angelicae pubescentis, 2 parts by weight of dried ginger, 1 part by weight of frankincense, 1 part by weight of myrrh, 450 parts by weight of medicinal white wax, 100 parts by weight of vaseline and 150 parts by weight of water.
3. The method for preparing the medicinal wax for treating knee osteoarthritis according to claim 1, comprising:
mixing white wax, vaseline and water, heating to melt, mixing with pericarpium Zanthoxyli, fructus Foeniculi, herba speranskiae tuberculatae, radix Clematidis, fructus Gleditsiae Abnormalis, rhizoma corydalis, rhizoma Chuanxiong, radix Angelicae Pubescentis, rhizoma Zingiberis, olibanum, and Myrrha, and cooling to obtain medicinal wax for treating knee osteoarthritis.
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| CN111632096A (en) * | 2020-06-29 | 2020-09-08 | 临沂职业学院 | Biological wax composition for treating osteoarthritis and preparation method thereof |
| CN114869946A (en) * | 2022-06-15 | 2022-08-09 | 河南中医药大学第一附属医院 | Traditional Chinese medicine wax moxibustion phase change paste and preparation and use methods thereof |
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| CN111632096A (en) * | 2020-06-29 | 2020-09-08 | 临沂职业学院 | Biological wax composition for treating osteoarthritis and preparation method thereof |
| CN114869946A (en) * | 2022-06-15 | 2022-08-09 | 河南中医药大学第一附属医院 | Traditional Chinese medicine wax moxibustion phase change paste and preparation and use methods thereof |
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