CN116492408A - Medicinal membrane capable of being used at home and relieving symptoms of knee arthritis and preparation method thereof - Google Patents
Medicinal membrane capable of being used at home and relieving symptoms of knee arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and provides a medicinal membrane capable of relieving knee arthritis symptoms for household use and a preparation method thereof, wherein the medicinal membrane comprises main material components and auxiliary material components, and the main material components comprise the following raw materials in parts by weight: 10 to 50g of gynostemma pentaphylla, 20 to 50g of sappan wood, 10 to 35g of mountain sea snail, 10 to 30g of prepared rhubarb, 10 to 50g of clematis root, 10 to 30g of garden balsam stem, 20 to 50g of rhizoma corydalis, 10 to 30g of liquorice, 9 to 20g of asarum, 10 to 50g of suberect spatholobus stem and 15 to 60g of honeysuckle stem; the adjuvant comprises vaseline and Cera flava. The stasis in the human body can be effectively removed through the matched use of the main material components; eliminating stagnation, relieving swelling, promoting blood circulation, removing blood stasis, relieving pain, promoting blood circulation, improving blood stasis state of local tissue, and dredging channels and collaterals. The traditional Chinese medicine can directly act on the focus part through the use of auxiliary material components, and has the advantages of quick response, no sensitization and no sensitization phenomenon; can be used continuously, and has the advantages of convenient use, no peculiar smell, no foreign matter feel, and no pollution to skin and clothes.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicinal membrane capable of being used at home for relieving symptoms of knee arthritis and a preparation method thereof.
Background
Knee Osteoarthritis (KOA) is a chronic degenerative joint disease, which is an inflammatory disease of joints and surrounding tissues of the human body, and the lesions are chronic, and are mostly found in middle-aged and later people. Clinically, redness, swelling, heat, pain, dysfunction and joint deformity of joints occur, pathological changes occur initially in articular cartilage, and later invade periarticular tissues such as subchondral bone plates and synovium, and are mainly characterized by cartilage degeneration and new bone formation at joint surfaces and edges. The pathogenesis is complex and is thought to be related to factors such as aging, trauma, inflammation, obesity, autoimmune reactions, metabolism and genetic and degenerative changes. Severe cases result in joint disability and affect the quality of life of the patient.
The KOA prevalence rate of symptoms in middle-aged and elderly people in China is 8.1%, and the disease has a certain growing trend, seriously influences the life quality of patients, has a certain disability rate, causes great burden to societies and families, and clinically shows pain, swelling and stiffness of knee joints. The traditional Chinese medicine has more modes for treating the disease and definite curative effect. The traditional Chinese medicine treatment mainly adopts acupuncture and moxibustion, belongs to one of the traditional therapies in China, has the characteristics of safety, economy and effectiveness, and has higher application value in knee arthritis treatment.
In the actual clinical process, many knee osteoarthritis patients often have joint movement dysfunction, go out inconveniently, delay treatment, and the treatment process needs family accompaniment, has increased time cost. The incidence of KOA is high, the recurrence rate is also high, and a simple and effective medical membrane for home use is a demand.
Disclosure of Invention
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a medicinal membrane capable of being used at home for relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 10 to 50g of gynostemma pentaphylla, 20 to 50g of sappan wood, 10 to 35g of mountain sea snail, 10 to 30g of prepared rhubarb, 10 to 50g of radix clematidis, 10 to 30g of garden balsam stem, 20 to 50g of rhizoma corydalis, 10 to 30g of liquorice, 9 to 20g of asarum, 10 to 50g of suberect spatholobus stem, 15 to 60g of honeysuckle stem and 15 to 50g of zhengshan kou black tea; the auxiliary materials comprise vaseline, paraffin and beeswax.
Gynostemma pentaphylla: lung-returning; spleen; the kidney meridian has effects of clearing heat, relieving inflammation, and invigorating qi deficiency.
Sappan wood: sappan wood has the effects of calming, entering liver meridian, promoting qi circulation, promoting blood circulation, removing blood stasis, reducing swelling and relieving pain.
Mountain conch: the Chinese medicinal composition has the effects of clearing heat, detumescence, detoxification and pus discharge.
Preparing rheum officinale: has effects of clearing heat and detoxicating, stopping bleeding, promoting blood circulation and removing blood stasis.
Radix Clematidis: it is indicated for bladder meridian, is a medicine for removing wind-dampness, and has the effects of dispelling wind-dampness and dredging meridian.
Speranskia Tuberculata (L.) Makino: has the effects of invigorating liver and spleen channels, relaxing tendons, promoting blood circulation, removing blood stasis, relieving swelling, removing toxic substances and relieving pain.
Rhizoma corydalis: promoting blood circulation, removing blood stasis, activating qi-flowing, and relieving pain.
Caulis Spatholobi: warm nature, good liver and kidney meridian tropism, and has the effects of relaxing tendons, activating collaterals, promoting blood circulation, enriching blood and relieving pain.
Caulis Lonicerae: has the effects of clearing away heat and toxic materials, dispelling pathogenic wind and relieving pain.
Asarum herb: has the effects of restoring lung, heart and kidney meridians, dispelling cold, dispelling wind and relieving pain.
Licorice root: tonifying qi, relieving pain, and harmonizing the effects of the medicines.
Mountain-normal small-seed black tea: anti-inflammatory, diuretic and repercussive effects
Vaseline and mineral wax, which are not absorbed by skin and form a protective film on the skin surface
Further, the main material comprises the following raw materials in parts by weight: 25-35 g of gynostemma pentaphylla, 30-35 g of sappan wood, 15-20 g of mountain sea snail, 10-20 g of prepared rheum officinale, 20-30 g of radix clematidis, 15-30 g of garden balsam stem, 35-45 g of rhizoma corydalis, 15-20 g of liquorice, 10-15 g of asarum, 25-40 g of caulis spatholobi, 25-50 g of honeysuckle stem and 20-35 g of zhengshan kou black tea.
Further, the main material comprises the following raw materials in parts by weight: 30-60 parts of paraffin, 50-100 parts of beeswax, 300-500 parts of Vaseline and 10-50 parts of shea butter.
The invention also provides a preparation method of the medical film capable of relieving the knee arthritis symptoms for household use, which comprises the following specific preparation steps:
step one: weighing the raw materials of the main material according to the parts by weight: 10-50 g of gynostemma pentaphylla, 20-50 g of sappan wood, 10-35 g of mountain sea snail, 10-30 g of prepared rheum officinale, 10-50 g of radix clematidis, 10-30 g of garden balsam stem, 20-50 g of rhizoma corydalis, 10-30 g of liquorice, 9-20 g of asarum, 10-50 g of caulis spatholobi, 15-60 g of honeysuckle stem and 15-50 g of zhengshan kombucha tea, and mixing the materials together to remove impurities, cleaning, drying and sterilizing;
step two: mixing the main material components and pulverizing into fine powder for later use;
step three: preparing auxiliary material components, namely weighing 30-60 g of paraffin and 50-100 g of beeswax in a clean measuring cup with 1000ml of capacity, firstly pouring the paraffin and the beeswax into the measuring cup, putting the measuring cup on a closed electric furnace for heating, adding 300-500g of Vaseline after the paraffin and the beeswax are dissolved, adding 10-50 g of shea butter after the Vaseline is completely dissolved, and closing the electric furnace until the paraffin and the beeswax are completely dissolved;
step four: preparing main material components, namely weighing 150-500 g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, and stirring the traditional Chinese medicine powder by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into a constant temperature box, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Further, in the first step, the temperature of drying is 50-60 ℃, and the drying is repeatedly lifted for 3 hours.
Further, in the second step, the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve completely and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Further, in the third step, the temperature of the electric furnace is 100 ℃ when the paraffin wax, the beeswax and the vaseline are dissolved.
Further, in the third step, the temperature of the electric furnace is 70 ℃ when the shea butter is dissolved.
Further, in the fourth step, 100ml of the liquid in which the auxiliary materials are dissolved is poured into each time.
Further, in the fifth step, the temperature of the incubator is 25 ℃.
The using method comprises the following steps:
taking out the prepared medicine film box, opening a sealing cover, putting into a microwave oven, heating for 4 minutes, taking out the fresh-keeping box, placing, selecting a wooden high-temperature-resistant meal spoon as a smearing tool, measuring the temperature of the medicine film below 45 ℃ by using a thermometer before smearing, firstly, putting a thickened fresh-keeping film on the lower pad of the knee at the affected side before smearing, smearing some medicine films at the center of the fresh-keeping film, putting the popliteal fossa of the knee at the affected side on the medicine film, then, smearing the front side, taking out a pasty medicine film, and smearing the pasty medicine film on the whole knee at the affected side, wherein the upper half section comprises Liang Qiuxue and blood sea acupoints; the lower half section comprises YINLINGQUAN acupoint and ZUSANLI acupoint, and the medicinal membrane flows on both sides of knee during application, and is not scraped, and the thickness of the whole medicinal membrane reaches 2-3 cm, and one side knee is applied with one box of medicinal membrane. All the medicine films are used up, the whole knee joint is tightly packed by a preservative film which is padded below the knee, the warm blanket is covered outside, after 30 minutes, the medicine films are cooled and solidified, the medicine films can be torn off in a whole, put into a box for later use, the medicine films cannot be remained on the skin, each box of medicine films can be continuously used for 6 times, and the medicine films can be discarded after being used, and then new medicine films are used.
The invention has the following beneficial effects:
(1) The medicinal film for relieving the knee osteoarthritis symptoms prepared by adopting the raw material formula disclosed by the invention has the main ingredients of gynostemma pentaphylla, sappan wood, conch, prepared rhubarb, radix clematidis, garden balsam stem, rhizoma corydalis, liquorice, zhengshan black tea, asarum, caulis spatholobi and honeysuckle stem, and the sappan wood has the effects of promoting qi circulation, activating blood circulation to remove blood stasis, and relieving swelling and pain; the conch has effects of clearing heat, detumescence, removing toxic substance, and expelling pus; radix Clematidis has effects of dispelling pathogenic wind and dampness and dredging channels and collaterals; the garden balsam stem has the effects of relaxing tendons, promoting blood circulation, removing blood stasis, relieving swelling, detoxifying and relieving pain; rhizoma corydalis has effects of promoting blood circulation, removing blood stasis, activating qi-flowing and relieving pain; caulis Spatholobi has effects of relieving rigidity of muscles and activating collaterals, promoting blood circulation, replenishing blood and relieving pain; the honeysuckle stem has the effects of clearing heat and detoxicating, dispelling wind and relieving pain; the Zhengshan black tea has the effects of diminishing inflammation, promoting urination and reducing swelling; the asarum has the effects of dispelling cold, dispelling wind and relieving pain, and can effectively remove stasis in human bodies through the matched use of the main material components; eliminating stagnation, relieving swelling, promoting blood circulation, removing blood stasis, relieving pain, promoting blood circulation, improving blood stasis state of local tissue, and dredging channels and collaterals.
(2) The auxiliary material components of the invention adopt vaseline and beeswax, which can not be absorbed by skin, can form a protective film on the skin surface, can be used as a humectant and also can play a role of a lubricant, can directly contact with human skin, and can directly act on focus parts by using the auxiliary material components, thus having quick response, no sensitization and no sensitization phenomenon; can be used continuously, and has the advantages of convenient use, no peculiar smell, no foreign matter feel, and no pollution to skin and clothes.
Drawings
Figure 1 is a graph comparing VAS values of a drug membrane set and a warm needle set before and after treatment.
Detailed Description
The following detailed description, taken in conjunction with the drawings and detailed description, should be taken as illustrative of the invention only and not as limiting, the examples being intended to provide those skilled in the art with a better understanding and appreciation of the inventive concepts, the scope of the invention being best understood from the appended claims.
Example 1
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 35g of gynostemma pentaphylla, 20g of sappan wood, 25g of mountain sea snail, 20g of prepared rheum officinale, 25g of radix clematidis, 25g of garden balsam stem, 20g of rhizoma corydalis, 15g of liquorice, 15g of asarum, 30g of caulis spatholobi, 30g of honeysuckle stem and 20g of zhengshan kohliana black tea; the auxiliary materials comprise 80g of paraffin, 40g of beeswax, 300g of Vaseline and 30g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 35g of gynostemma pentaphylla, 20g of sappan wood, 25g of mountain sea snail, 20g of prepared rheum officinale, 25g of radix clematidis, 25g of garden balsam stem, 20g of rhizoma corydalis, 15g of liquorice, 15g of asarum, 30g of caulis spatholobi, 30g of honeysuckle stem and 20g of zhengshan kohliana black tea; mixing the materials together, removing impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary materials, namely taking a clean measuring cup with 1000ml capacity, weighing 80g of paraffin and 40g of beeswax, pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace at the heating temperature of 100 ℃, adding 300g of Vaseline after the paraffin and the beeswax are heated, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, and finally adding 30g of shea butter until the paraffin and the beeswax are completely dissolved, and closing the electric furnace;
step four: preparing main material components, namely weighing 200g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 2
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 50g of gynostemma pentaphylla, 50g of sappan wood, 35g of mountain sea snail, 30g of prepared rheum officinale, 50g of radix clematidis, 30g of garden balsam stem, 50g of rhizoma corydalis, 30g of liquorice, 20g of asarum, 50g of caulis spatholobi, 60g of honeysuckle stem and 15g of zhengshan kohliana black tea; the auxiliary materials comprise 60g of paraffin, 100g of beeswax, 500g of Vaseline and 50g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 50g of gynostemma pentaphylla, 50g of sappan wood, 35g of mountain sea snail, 30g of prepared rheum officinale, 50g of radix clematidis, 30g of garden balsam stem, 50g of rhizoma corydalis, 30g of liquorice, 20g of asarum, 50g of caulis spatholobi, 60g of honeysuckle stem and 15g of zhengshan small-seed black tea, and mixing the above materials together to remove impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 60g of paraffin and 100g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 500g of Vaseline after the paraffin and the beeswax are dissolved, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, finally adding 50g of shea butter until the paraffin and the beeswax are completely dissolved, closing the electric furnace, and measuring the temperature;
step four: preparing main material components, namely weighing 300g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 3
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 25g of gynostemma pentaphylla, 30g of sappan wood, 15g of mountain sea snail, 10g of prepared rheum officinale, 20g of radix clematidis, 15g of garden balsam stem, 35g of rhizoma corydalis, 15g of liquorice, 10g of asarum, 25g of caulis spatholobi, 25g of honeysuckle stem and 25g of zhengshan small-seed black tea; the auxiliary materials comprise 30g of paraffin, 50g of beeswax, 300g of Vaseline and 10g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing 25g of gynostemma pentaphylla, 30g of sappan wood, 15g of mountain sea snail, 10g of prepared rheum officinale, 20g of radix clematidis, 15g of garden balsam stem, 35g of rhizoma corydalis, 15g of liquorice, 10g of asarum, 25g of suberect spatholobus stem, 25g of honeysuckle stem and 25g of zhengshan kohliana tea according to parts by weight, blending the materials together, removing impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 30g of paraffin and 50g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 300g of Vaseline after the paraffin and the beeswax are dissolved, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, finally adding 10g of shea butter until the paraffin and the beeswax are completely dissolved, closing the electric furnace, and measuring the temperature;
step four: preparing main material components, namely weighing 200g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 4
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 35g of gynostemma pentaphylla, 35g of sappan wood, 20g of mountain sea snail, 20g of prepared rheum officinale, 30g of radix clematidis, 30g of garden balsam stem, 45g of rhizoma corydalis, 20g of liquorice, 15g of asarum, 40g of caulis spatholobi, 50g of honeysuckle stem and 40g of zhengshan small-seed black tea; the auxiliary materials comprise 60g of paraffin, 100g of beeswax, 350g of vaseline and 50g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 35g of gynostemma pentaphylla, 35g of sappan wood, 20g of mountain sea snail, 20g of prepared rheum officinale, 30g of radix clematidis, 30g of garden balsam stem, 45g of rhizoma corydalis, 15-20 g of liquorice, 15g of asarum, 40g of caulis spatholobi, 50g of honeysuckle stem and 40g of zhengshan small-seed black tea; mixing the materials together, removing impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 60g of paraffin and 100g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 350g of Vaseline after the paraffin and the beeswax are dissolved, reducing the temperature to 70 ℃ after the Vaseline is completely dissolved, and finally adding 50g of shea butter until the paraffin and the beeswax are completely dissolved, closing the electric furnace, and measuring the temperature;
step four: preparing main material components, weighing 250g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 5
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 30g of gynostemma pentaphylla, 20g of sappan wood, 10g of mountain sea snail, 10g of prepared rheum officinale, 10g of radix clematidis, 10g of garden balsam stem, 20g of rhizoma corydalis, 10g of liquorice, 9g of asarum, 10g of caulis spatholobi, 15g of honeysuckle stem and 20g of zhengshan kohliana black tea; the auxiliary materials comprise 30g of paraffin, 50g of beeswax, 300g of Vaseline and 10g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 30g of gynostemma pentaphylla, 20g of sappan wood, 10g of mountain sea snail, 10g of prepared rheum officinale, 10g of radix clematidis, 10g of garden balsam stem, 20g of rhizoma corydalis, 10g of liquorice, 9g of asarum, 10g of caulis spatholobi, 15g of honeysuckle stem and 20g of zhengshan small-seed black tea, and mixing the above materials together to remove impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 30g of paraffin and 50g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 300g of Vaseline after the paraffin and the beeswax are dissolved, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, and finally adding 10g of shea butter until the electric furnace is completely dissolved finally, and closing the electric furnace;
step four: preparing main material components, weighing 150g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 6
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 30g of gynostemma pentaphylla, 35g of sappan wood, 26g of mountain sea snail, 20g of prepared rheum officinale, 25g of radix clematidis, 20g of garden balsam stem, 35g of rhizoma corydalis, 20g of liquorice, 14g of asarum, 30g of caulis spatholobi, 40g of honeysuckle stem and 32g of zhengshan kohliana black tea; the auxiliary materials comprise 45g of paraffin, 75g of beeswax, 350g of Vaseline and 25g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 30g of gynostemma pentaphylla, 35g of sappan wood, 26g of mountain sea snail, 20g of prepared rheum officinale, 25g of radix clematidis, 20g of garden balsam stem, 35g of rhizoma corydalis, 20g of liquorice, 14g of asarum, 30g of caulis spatholobi, 40g of honeysuckle stem and 32g of zhengshan small-seed black tea, and mixing the above materials together to remove impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 45g of paraffin and 75g of beeswax, pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 350g of Vaseline after the paraffin and the beeswax are dissolved, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, adding 25g of shea butter until the electric furnace is completely dissolved at last, and closing the electric furnace;
step four: preparing main material components, namely weighing 200g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Example 7
The embodiment provides a medical film capable of being used at home and relieving symptoms of knee arthritis, which comprises main material components and auxiliary material components, wherein the main material components comprise the following raw materials in parts by weight: 30g of gynostemma pentaphylla, 32g of sappan wood, 17g of mountain sea snail, 15g of prepared rhubarb, 25g of radix clematidis, 20g of garden balsam stem, 40g of rhizoma corydalis, 17g of liquorice, 32g of asarum, 37g of suberect spatholobus stem, 37g of honeysuckle stem and 27g of zhengshan kohliana black tea; the auxiliary materials comprise 30g of paraffin, 50g of beeswax, 300g of Vaseline and 10g of shea butter.
The preparation method comprises the following specific steps:
step one: weighing the raw materials of the main material according to the parts by weight: 30g of gynostemma pentaphylla, 32g of sappan wood, 17g of mountain sea snail, 15g of prepared rheum officinale, 25g of radix clematidis, 20g of garden balsam stem, 40g of rhizoma corydalis, 17g of liquorice, 32g of asarum, 37g of caulis spatholobi, 37g of honeysuckle stem and 27g of zhengshan race black tea, and mixing the above materials together to remove impurities, cleaning, drying and sterilizing; wherein the temperature of the drying is 50-60 ℃, and the drying is repeatedly carried out for 3 hours.
Step two: mixing the main material components and pulverizing into fine powder for later use; the standard of the fine powder means that the fine powder can pass through a 100-mesh sieve in its entirety and contains not less than 95% of the powder which can pass through a 120-mesh sieve.
Step three: preparing auxiliary material components, namely taking a clean measuring cup with 1000ml capacity, weighing 30g of paraffin and 50g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, heating the measuring cup on a closed electric furnace, wherein the heating temperature of the electric furnace is 100 ℃, adding 300g of Vaseline after the paraffin and the beeswax are dissolved, reducing the heating temperature of the electric furnace to 70 ℃ after the Vaseline is completely dissolved, and finally adding 10g of shea butter until the electric furnace is completely dissolved finally, and closing the electric furnace;
step four: preparing main material components, namely weighing 300g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, pouring 100ml of the liquid into each time, and stirring by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into an incubator with the temperature of 25 ℃, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
Experimental example 1
The films with different proportions in examples 1-7 are respectively used for treating KOA patients, and the numerical comparison of the knee joint function score (Lysholm) before and after treatment is observed; the scoring system consists of 8 questions, the score is 0-100, and the higher the score is, the better the functional state of the patient is; the Lysholm score is more prone to activities of daily living than other scoring scales. The results of the Lysholm scoring for examples 1-7 are shown in Table 1, as compared before and after treatment:
TABLE 1
P < 0.001 compared to before and after treatment in the group; example 1 compares with the other groups, < P < 0.05 (0.02, 0.04, 0.01, 0.044, 0.003, 0.016)
According to Table 1, according to the medicinal films with different proportions prepared in examples 1-7, after treatment by using the medicinal films, lysholm scores of KOA patients are increased and the increase is obvious, the medicinal films prepared by the scheme can obviously improve knee joint functions, and 35g of gynostemma pentaphylla, 20g of sappan wood, 25g of conch, 20g of prepared rheum officinale, 25g of radix clematidis, 25g of garden balsam stem, 20g of rhizoma corydalis, 15g of liquorice, 15g of asarum, 30g of caulis spatholobi, 30g of honeysuckle stem and 20g of small-sized black tea of Zhengshan are adopted; the auxiliary materials comprise 80g of paraffin, 40g of beeswax, 300g of vaseline and 30g of shea butter, and the effect of the prepared medicinal film is more obvious.
Experimental example 2
In a certain clinic department, 82 cases of knee osteoarthritis of old people who visit the clinic before are selected, and the cases are divided into warm needle groups and medicinal membrane groups by adopting a random digital method, wherein the warm needle groups comprise 15 cases of men and 26 cases of women, the ages of the men and the women are 55-80 years, the average ages of the men and the women are 65.73 +/-6.13 years, the disease course is 9-96 months, and the average disease course is 36.61 +/-21.19 months; in the medicine film group, 17 men and 24 women with the ages of 55-79 years old, the average age of 65.80 +/-7.15 years old, the course of disease of 12-96 months and the average course of disease of 33.83 +/-21.65 months. Average age two groups compared, P value 0.149; the average disease course was compared with two groups, the P value was 0.811 and the P value was less than 0.05, and the two groups had no obvious difference in age and disease course.
Meets the standard of (1) diagnosis of knee osteoarthritis and diagnosis of knee joint diseases in traditional Chinese medicine; (2) has good cognitive function and can be matched with the whole course of treatment; (3) the patella floating test is negative; (4) age above 55 years old; (5) study content was known and participants were agreed.
Exclusion criteria (1) knee osteoarthritis patients with surgical treatment indications; (2) psychotic patients with a violent tendency; (3) a patient in the near end; (4) combining infectious diseases, and isolating the infectious diseases separately; (5) similar treatments have been accepted recently; (6) skin ulcer exists at the knee joint part; (7) treating knee osteoarthritis again.
Therapeutic method
Warm needle group: the acupoints of the affected knee, the outer knee, the eye, the three inner feet, the hills, the blood sea and the yin ling are selected. The patient is in supine position, and a disposable sterile acupuncture needle with the thickness of 0.3mm multiplied by 40mm is selected. Sterilizing needle and skin surface, directly puncturing acupoints, performing twisting, selecting inner and outer knee and eye acupoints for warm acupuncture after qi is passed, adding thin paper board for separating acupoints, selecting moxibustion strip with length of 3cm, inserting into needle handle, igniting moxa strip, performing moxibustion, and leaving needle for 30min for 2 times. 3 times per week and 4 weeks as a treatment course.
Medicine film group: the medical film prepared by the components in the embodiment 1 is subjected to hot compress, the first two weeks are subjected to hot compress in an outpatient service, and the second two weeks are subjected to hot compress in a home, and the outpatient service is followed by telephone call. 3 times per week, one knee joint, one pack of films can be used 6 times, 2 packs of films are prepared for each treatment course, and one treatment course is 4 weeks.
And (3) observing the indexes:
(1) Efficacy index
The curative effect judgment standard of the study is prepared by referring to the curative effect evaluation standard of the traditional Chinese medicine bone traumatology clinical diagnosis and treatment guide knee arthralgia (knee osteoarthritis) and combining the pain relieving condition and the knee joint function recovering condition of a patient.
Clinical cure: the knee pain completely disappears, and the knee joint functions normally;
the effect is shown: the knee joint is slightly painful, normal movement of the knee joint is not affected, but pain is slightly aggravated when the knee joint is overactive; improvement: the knee joint pain is slightly obvious but does not affect the normal movement of the knee joint;
invalidation: the pain of the knee joint is not obviously relieved, and the knee joint can not normally move.
Total effective rate= (total number of cases-ineffective cases)/total number of cases×100%.
(2) VAS scoring
The VAS score, i.e., the pain class score, is a visual simulation method for assessing pain severity. The scoring criteria were 10 aliquots using a ruler, 0 no pain, 1-3 mild pain, 4-6 moderate pain, and 7-10 severe pain.
(3) WOMAC osteoarthritis index
The general scale covers 3 dimensions of pain (5 items), stiffness (2 items) and joint function (17 items) by adopting the university of marst, western great lake and marst, osteoarthritis index (WOMAC osteoarthritis index), each item option is respectively provided with 1-5 minutes according to the severity, and the changes of knee joint pain, morning stiffness, activity and the like are respectively observed before and after treatment, wherein the higher the score is, the more serious the illness state is.
The scoring table effectively reflects the conditions before and after treatment, such as patient satisfaction, and is an assessment table for OA patients in wide use.
(4) Recurrence rate
Follow-up for 3 months and 6 months after treatment, the number of cases changed from effective to ineffective after treatment is the number of recurrence cases.
Therapeutic results
(1) The comparison of the drug film group and the warm needle group according to the curative effect evaluation standard and combining the pain relieving condition of the patient and the knee joint function recovering condition is shown in the table 2.
TABLE 2
| Group of | The number of people involved in the treatment | Healing | Has obvious effect | Improvement of | Invalidation of | Total effective rate |
| Warm needle group | 41 | 4 | 19 | 10 | 8 | 80.49％ |
| Medicinal film group | 41 | 6 | 20 | 10 | 5 | 87.80％ |
The χ2 value was 4.267 and the p value was 0.833
After one treatment course of warm acupuncture treatment, 4 cases are cured, 19 cases are obviously effective, 10 rows are improved, 8 cases are ineffective, and the total effective rate is 80.49%; after the warm needle is combined with the medicine film group for one treatment course, 6 cases are cured, 20 cases are obvious, 10 cases are improved, 5 cases are invalid, and the total effective rate is 87.80%; compared with the two groups, the curative effect of the medicinal membrane group is higher than that of the warm needle group (P is more than 0.05).
(2) The pairs of drug film sets and warm needle sets are shown in table 3 based on the VAS values quantified for pain.
TABLE 3 Table 3
| Group of | The number of people involved in the treatment | Before treatment | After treatment | t value | P value |
| Warm needle group | 41 | 7.61±1.05 | 3.54±2.10 | 12.406 | 0.000* |
| Medicinal film group | 41 | 7.41±1.20 | 2.71±2.00 | 20.498 | 0.000* |
P < 0.001 compared to before treatment; the P value was 0.071 compared to the warm needle group after treatment.
In one treatment course after treatment, the warm needle group is 3.54+/-2.10 minutes, and compared with 7.61+/-1.05 minutes before treatment, the warm needle group has obvious difference (P is less than 0.001) before and after treatment; the value of the medicine film group before treatment is 7.41+/-1.20 minutes, the value of the medicine film group after treatment is 2.71+/-2.00 minutes, the medicine film group has obvious difference before and after treatment, the t value of the warm needle group is 12.406 when the two groups are compared, and the t value of the medicine film group is 20.498, so that the treatment effect of the medicine film group is better.
Figure 1 more intuitively shows the difference between VAS before and after treatment of the acupuncture group and the drug membrane group, and the decrease of VAS value after treatment of the drug membrane group is more remarkable.
(3) The comparison of WOMAC osteoarthritis index was followed, and the comparison of the drug membrane group and the warm needle group is shown in table 4.
TABLE 4 Table 4
P < 0.001 compared to prior to treatment in the same group; compared with the warm needle group after treatment, P is less than 0.05 (0.679, 0.578, 0.019)
After a treatment course, the warm needle group and the medicinal membrane group are improved in pain, stiffness and joint functions, and the medicinal membrane group effectively improves the pain, stiffness and movement function symptoms (P is less than 0.001) of knee joints of the old; the efficacy of the medicinal membrane group on relieving the knee joint movement function is obviously better than that of a warm needle group (P is less than 0.05).
(4) The comparison of recurrence rates at 3 months and 6 months follow-up after treatment is shown in Table 5.
TABLE 5
| Group of | The number of people involved in the treatment | 3 months after treatment | 6 months after treatment | Recurrence rate |
| Warm needle group | 33 | 3(9.09) | 4(12.12) | 21.21 |
| Medicinal film group | 36 | 1(2.78) | 2(5.56) | 8.33 |
P < 0.001 compared to before treatment
In follow-up of 3 months and 6 months after treatment, the recurrence rate of the warm needle group is 9.09% and 12.12%, respectively, and the total recurrence rate is 21.21%; the temperature needle combined medicine film components are 2.78 percent and 5.56 percent respectively, and the total recurrence rate is 8.33 percent. Compared with the two groups, the recurrence rate of the medicinal membrane group is obviously lower than that of the warm needle group.
In conclusion, the medicinal film for relieving the knee osteoarthritis symptoms prepared by adopting the raw material formula disclosed by the invention has the main ingredients of gynostemma pentaphylla, threo, conch, prepared rhubarb, radix clematidis, garden balsam stem, rhizoma corydalis, liquorice, asarum, caulis spatholobi, caulis lonicerae and zhengshan black tea, and the sappan wood has the effects of promoting qi circulation, activating blood circulation to remove blood stasis, and relieving swelling and pain; the conch has effects of clearing heat, detumescence, removing toxic substance, and expelling pus; radix Clematidis has effects of dispelling pathogenic wind and dampness and dredging channels and collaterals; the garden balsam stem has the effects of relaxing tendons, promoting blood circulation, removing blood stasis, relieving swelling, detoxifying and relieving pain; rhizoma corydalis has effects of promoting blood circulation, removing blood stasis, activating qi-flowing and relieving pain; caulis Spatholobi has effects of relieving rigidity of muscles and activating collaterals, promoting blood circulation, replenishing blood and relieving pain; the honeysuckle stem has the effects of clearing heat and detoxicating, dispelling wind and relieving pain; the Zhengshan black tea has the effects of diminishing inflammation, promoting urination and reducing swelling; herba asari has effects of dispelling cold, dispelling pathogenic wind and relieving pain, and can effectively remove blood stasis in human body by mixing the main ingredients according to a certain proportion; eliminating stagnation, relieving swelling, promoting blood circulation, removing blood stasis, relieving pain, promoting blood circulation, improving blood stasis state of local tissue, and dredging channels and collaterals.
While preferred embodiments of the present application have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the application.
Claims (10)
1. The medical film for relieving the knee arthritis symptoms, which can be used at home, comprises a main material component and an auxiliary material component, and is characterized in that the main material component comprises the following raw materials in parts by weight: 10 to 50g of gynostemma pentaphylla, 20 to 50g of sappan wood, 10 to 35g of mountain sea snail, 10 to 30g of prepared rhubarb, 10 to 50g of radix clematidis, 10 to 30g of garden balsam stem, 20 to 50g of rhizoma corydalis, 10 to 30g of liquorice, 9 to 20g of asarum, 10 to 50g of suberect spatholobus stem, 15 to 60g of honeysuckle stem and 15 to 50g of zhengshan kou black tea; the auxiliary materials comprise vaseline, paraffin and beeswax.
2. The medical film for relieving symptoms of knee arthritis for home use according to claim 1, wherein the main ingredients comprise the following raw materials in parts by weight: 25-35 g of gynostemma pentaphylla, 30-35 g of sappan wood, 15-20 g of mountain sea snail, 10-20 g of prepared rheum officinale, 20-30 g of radix clematidis, 15-30 g of garden balsam stem, 35-45 g of rhizoma corydalis, 15-20 g of liquorice, 10-15 g of asarum, 25-40 g of caulis spatholobi, 25-50 g of honeysuckle stem and 20-35 g of zhengshan kou black tea.
3. The medical film for relieving symptoms of knee arthritis for home use according to claim 1, wherein the main ingredients comprise the following raw materials in parts by weight: 30-60 parts of paraffin, 50-100 parts of beeswax, 300-500 parts of Vaseline and 10-50 parts of shea butter.
4. A method for preparing a medical film for alleviating symptoms of knee arthritis for home use according to any one of claims 1 to 3, wherein the specific preparation steps are as follows:
step one: weighing the raw materials of the main material according to the parts by weight: 10-50 g of gynostemma pentaphylla, 20-50 g of sappan wood, 10-35 g of mountain sea snail, 10-30 g of prepared rheum officinale, 10-50 g of radix clematidis, 10-30 g of garden balsam stem, 20-50 g of rhizoma corydalis, 10-30 g of liquorice, 9-20 g of asarum, 10-50 g of caulis spatholobi, 15-60 g of honeysuckle stem and 15-50 g of zhengshan kombucha tea, and blending the materials together to remove impurities, cleaning, drying and sterilizing;
step two: mixing the main material components and pulverizing into fine powder for later use;
step three: preparing auxiliary material components, taking a clean measuring cup with 1000ml capacity, weighing 30-60 g of paraffin and 50-100 g of beeswax, firstly pouring the paraffin and the beeswax into the measuring cup, putting the measuring cup on a closed electric furnace for heating, adding 300-500g of Vaseline after the paraffin and the beeswax are dissolved, adding 10-50 g of shea butter after the Vaseline is completely dissolved, and closing the electric furnace until the paraffin and the beeswax are completely dissolved.
Step four: preparing main material components, namely weighing 150-500 g of the traditional Chinese medicine powder for standby in the step one, pouring the traditional Chinese medicine powder into a clean glass container, pouring the liquid dissolved in the step three into the traditional Chinese medicine powder in batches, and stirring the traditional Chinese medicine powder by using a stirrer until the traditional Chinese medicine powder is completely blended into the liquid to form paste;
step five: and (3) preparing a clean food-grade preservation box capable of being heated by a microwave oven, pouring the pasty liquid in the fourth step into the preservation box, putting the preservation box into a constant temperature box, naturally cooling, taking out the preservation box after at least 12 hours, and covering a sealing cover.
5. The method for preparing a medical film for alleviating symptoms of knee osteoarthritis for home use according to claim 4, wherein in the first step, the temperature of drying is 50-60 ℃, and the drying is repeatedly raised and lowered for 3 hours.
6. The method for preparing a medical film for alleviating symptoms of knee osteoarthritis for home use according to claim 4, wherein in the second step, the fine powder is a powder which can pass through 100 mesh sieve completely and contains not less than 95% of powder which can pass through 120 mesh sieve.
7. The method for preparing a medical film for alleviating symptoms of gonarthritis for home use according to claim 4, wherein in the third step, the temperature of the electric furnace is 100 ℃ when paraffin, beeswax and vaseline are dissolved.
8. The method for preparing a medical film for alleviating symptoms of gonarthritis, which can be used at home, according to claim 4, wherein in the third step, the temperature of the electric furnace is 70 ℃ when the shea butter is dissolved.
9. The method for preparing a medical film for alleviating symptoms of knee osteoarthritis for home use according to claim 4, wherein in the fourth step, 100ml of the liquid in which the auxiliary material is dissolved is poured each time.
10. The method for preparing a medical film for alleviating symptoms of knee osteoarthritis for home use according to claim 4, wherein in the fifth step, the temperature of the incubator is 25 ℃.
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