CN114869930A - Silver strip powder for traditional Chinese medicine composition and preparation process and application thereof - Google Patents

Silver strip powder for traditional Chinese medicine composition and preparation process and application thereof Download PDF

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Publication number
CN114869930A
CN114869930A CN202210318884.XA CN202210318884A CN114869930A CN 114869930 A CN114869930 A CN 114869930A CN 202210318884 A CN202210318884 A CN 202210318884A CN 114869930 A CN114869930 A CN 114869930A
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silver
powder
silver strip
strips
chinese medicine
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CN114869930B (en
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赵站周
赵杰
李晓艳
赵科杰
智娟娟
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract

A preparation process of the silver strip powder for the traditional Chinese medicine composition comprises the steps of material selection, cleaning, selection, blanching, drying, crushing, sieving, packaging and the like, and the prepared silver strip powder for the traditional Chinese medicine composition can be applied to traditional Chinese medicine prescriptions of constipation, large intestine melanosis or irritable bowel syndrome. The process of the invention takes fresh silver strips as raw materials, and the improvement of the preparation and processing process can furthest reserve and exert the effective pharmacological components in the fresh silver strips, and prepare the silver strip powder which is convenient to store and transport, convenient to use, remarkable in medicinal effect, capable of being used alone or compatible with a traditional Chinese medicine composition and has better treatment effect on constipation, large intestine melanosis or irritable bowel syndrome, thereby expanding the application of the silver strip powder in medical clinic.

Description

Silver strip powder for traditional Chinese medicine composition and preparation process and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a silver strip powder for a traditional Chinese medicine composition, a preparation process thereof and application thereof in treating constipation, large intestine melanosis or irritable bowel syndrome and the like.
Background
Silver strips (Stachys floridana Schuttl. ex Benth) also named as Diling, Hemsleya amabilis, Miquel silverweed, Hemsleya amabilis, etc., are perennial root herbaceous plants of Stachys genus of Labiatae family. The leaf of silver leaf is oval, and the underground rhizome is white, cylindrical and slender, like the stem of grape, and has fine texture, crisp, tender and succulent, and white meat quality. Mainly produced in northern China, south China, Xinjiang and other places, is mostly in a semi-wild state, and the artificial cultivation is mainly concentrated on the elytrigs in Henan, and accounts for more than 95 percent of the total cultivation amount in China. Because it is white like silver, crisp, tender and tasty, has no fiber, no residue, rich nutrition and good taste. Thousands of years of history of first-class dishes and application are existed in China. According to the record of Elytrigs county, silver strips have been used as palace tributes in all ages since the Tang Dynasty. In 2005, 6.1.1, the State administration of quality supervision, inspection and quarantine issues bulletins, and the original region protection is formally obtained by the silver bar of Elytrigs. The department of agriculture 8.8.17.2011 notes elytrigs silver as a national geographical marking product.
The silver strips are rich in stachyose, vitamin C, crude protein, fat, carbohydrate, amino acid and organic substances and the like, and have the effects of reducing blood fat, softening blood vessels and improving blood circulation. Research shows that the root of the silver strips contains stachyose, stachydrine, choline and other bioactive substances, has the effects of moistening lung, enriching blood, tonifying kidney and moistening intestines, and can relax the bowels and treat asthma, cough due to lung deficiency, lumbago due to kidney deficiency, scrofula, hemoptysis and other diseases. The oligosaccharide can enhance humoral immunity and cellular immunity, and is a vegetable with high medical and health promotion value. The stachyose product produced with the plant material has stachyose content 2-3 times higher than that extracted with common soybean material.
Stachyose (stachyyose) is a naturally-occurring functional oligomeric tetrasaccharide, has the characteristics of high stability, low sweetness, low heat and low heat, can obviously promote the proliferation of beneficial flora such as bifidobacterium, lactobacillus and the like in gastrointestinal tracts, can quickly improve the internal environment of human digestive tracts, and can regulate the balance of microbial flora, and is known as a 'natural super-strong bifidus factor'. With the rapid development of world economy and the increasing attention of people on health, stachyose has attracted extensive attention in food ingredients, the market demand is continuously increased, and the prospect is wide. The pioneer study found that the major alpha-Galactooligosaccharides (alpha-GOS) in silver bars were stachyose, accounting for about 86.03% of the total alpha-GOS content. Research shows that the silver bar alpha-GOS has good immunoregulation activity to organisms. The silver bar alpha-GOS can obviously improve the spleen index of a CTX immune suppression mouse, the ear swelling degree of DTH and the activity of lysozyme in serum.
In recent years, silver-strip research has mainly focused on silver-strip planting and tuber cultivation techniques. The utilization mainly stays at the food processing stages of salting, saucing, can making and storing and the like, the application in deep processing, traditional Chinese medicine composition, medical health preserving and health care is very limited, and the medicinal value of the silver strips cannot be improved.
The existing silver strip processing technology and application mainly have the following aspects: 1. fresh silver strips: in three or four months from 11 months to early spring in the lunar calendar, silver strips are ripe and harvested, and people's generations use fresh silver strips to be scalded with water (vegetables are taken out after being put in boiled water and slightly boiled) and then are pounded into paste to be used as a single proved prescription for treating diseases. 2. And (3) silver strip dry product: the fresh silver strips are cleaned, boiled with water, dried in the sun in the natural environment, and dried to obtain the dried silver strips which are eaten as single proved prescriptions or dried vegetables. 3. Cold dish with silvery pickles (from scratch). 4. The silver strips are cooked (from scratch). 5. The silver bar can is prepared by modern processing technology (omitted from the following).
The existing silver strip processing technology has the main problems that: 1. the fresh silver strips are not suitable for long-term storage, and the service life is short (generally two or three months from 11 months to early spring in the lunar calendar). 2. The dried silver strips are slightly yellow or earthy yellow in natural environment, the taste is bitter and astringent, and the dried silver strips are easy to turn yellow, black and deteriorate. Is greatly influenced by external factors, environmental pollution and the like, and can cause harm to human health after being eaten. The cold-mixed silver strips, the cooked silver strips and the modern processing technology are made into silver strips cans and the like, and the food attributes and the biological effects of the silver strips are qualitatively changed, so the silver strips are not suitable to be used as medicines or Chinese medicinal compositions.
Disclosure of Invention
The technical purpose of the invention is as follows: the fresh silver strip is used as a raw material, effective pharmacological components in the fresh silver strip are retained and exerted to the maximum extent through the improvement of a preparation processing technology, and the silver strip powder which is convenient to store and transport, convenient to use, remarkable in medicinal effect, capable of being used independently or in combination with a traditional Chinese medicine composition and has a good treatment effect on constipation, large intestine melanosis or irritable bowel syndrome is prepared, so that the application of the silver strip powder in medical clinic is expanded.
In order to realize the purpose, the invention adopts the following technical scheme: the preparation process of the silver strip powder for the traditional Chinese medicine composition comprises the following steps:
(1) selecting materials
Selecting thick, hollow and fracture-free fresh underground silver strip rhizomes as raw materials;
(2) cleaning the substrate
Spreading the silver strip raw material selected in the step (1) on a cleaning machine, and cleaning the silver strip raw material in a continuous flooding washing mode to ensure that the surface of the silver strip raw material is clean and free of impurities;
(3) and refining
Manually picking and detecting the silver strips cleaned in the step (2), and removing bad heads, yellow heads, dry heads, tender heads, impurities and deformed silver strips;
(4) blanching the water
Blanching the silver strips selected in the step (3) in boiling water for 1-2min, continuously turning over the silver strips in the blanching process, and immediately taking the silver strips out of the pot for cooling after the blanching treatment is finished;
(5) and drying the mixture
Placing the silver strips cooled in the step (4) in a drying dehumidifier, controlling the drying temperature to be 40-80 ℃, and performing drying treatment for 5-12h to obtain a dry silver strip product with the water content not higher than 12% for later use;
(6) pulverizing the above materials
Putting the dried silver strips prepared in the step (5) into a grinder for grinding;
(7) and sieving the mixture
Sieving the silver strips crushed in the step (6) to obtain silver strip powder with the fineness of 24-50 meshes for later use;
(8) and a package
And (4) sterilizing the silver strip powder prepared in the step (7), sealing and packaging, and after the silver strip powder is qualified through inspection, printing a code, labeling and warehousing to obtain the finished silver strip powder for the traditional Chinese medicine composition.
Preferably, in the step (1), the length of the underground rhizome of the fresh silver strip is not less than 20 cm.
Preferably, in the step (2), the silver strip raw material spread on the cleaning machine is cleaned by using a high-pressure spray head.
Preferably, in the step (2), the height of the silver strip raw material spread on the cleaning machine should not exceed 5 cm.
Preferably, in the blanching treatment process in the step (4), after the silver strips are put into the pot, the water temperature in the pot should be kept at 90-96 ℃, and the water in the pot should be capable of completely immersing the silver strips.
Preferably, in the step (5), 2 to 5 layers of silver strips are uniformly spread on the steel wire meshes in the process of drying in a drying dehumidifier.
The silver strip powder for the Chinese medicinal composition prepared by the method is used.
The obtained silver strip powder can be made into decoction, powder, pill, granule or oral liquid.
The prepared silver strip powder for the traditional Chinese medicine composition can be compounded with at least one of tremella, sesame, American ginseng, astragalus, poria cocos, bighead atractylodes rhizome, Chinese yam, tartary buckwheat, malt, wheat bran, white hyacinth bean, black date, wild jujube, peach kernel, fructus amomi, nutmeg, arillus longan, wolfberry fruit, kelp, endothelium corneum gigeriae galli, sea buckthorn and lalang grass rhizome to prepare decoction, powder, pills, medicinal granules or oral liquid for use.
The application of the silver strip powder for the traditional Chinese medicine composition in a traditional Chinese medicine prescription for constipation, large intestine melanosis or irritable bowel syndrome.
The invention has the beneficial effects that:
1. the preparation process of the invention takes the medicine and food dual-purpose vegetable-silver strips as the raw material, and comprehensively adopts a multi-step and orderly processing method, so that the biological active substances such as stachyose, stachydrine, choline and the like in the fresh silver strips and the nutrient substances such as vitamin C, crude protein, protein and the like are reserved and enriched to the maximum extent, and the finished silver strip powder has the effects of increasing the nutrition of intestinal tracts, improving the environment of the intestinal tracts, recovering the function of the intestinal tracts and improving the immunity of organisms. The finished product of the silver bar powder can be used independently or compounded in a traditional Chinese medicine composition, and the empirical formula shows that the silver bar powder has a good treatment effect on constipation, large intestine melanosis or irritable bowel syndrome, and has an obvious medicinal function and a good use effect.
2. The preparation process of the invention adopts a more scientific and effective blanching way to carry out primary processing on the fresh silver strips aiming at the plant characteristics of the fresh silver strip raw material. The whole blanching process emphasizes 'pot cleaning, water width and fire excess', a large amount of water is used for blanching the fresh silver strips with high water content in a relatively high temperature and in a rapid stirring manner, the blanching mode avoids over-cooking and nutrient loss caused by the overlarge heating area of the fresh silver strips, the blanching time of 1-2min can remove grass sourness, peculiar smell, astringent taste and the like in the fresh silver strips, and when free water in partial cells in the silver strips is discharged, the loss of water-soluble nutrient components such as vitamin C and the like is reduced, so that the drug effect of the silver strips is guaranteed and the drug property of the silver strips is kept.
3. In the drying step, the blanched silver strips are processed by spreading 2-5 layers and drying at 40-80 ℃ for 5-12 hours. The processing technology of the step is to slowly evaporate and release water in cell tissues at a relatively low temperature according to the blanched texture and humidity characteristics of the silver strips, so that the aims of reducing toxicity and keeping medicinal efficacy of the silver strips are fulfilled. The drying temperature of 40-80 ℃ can also effectively avoid overlong time consumption and large power consumption caused by overlow drying temperature; the silver strips are shriveled and deteriorated due to overhigh drying temperature, the internal bioactive components are damaged, and the like. In the subsequent crushing and sieving steps, according to the attribute of the silver strip raw material which does not contain dietary fiber, the silver strip powder of 24-50 meshes is specifically selected for use as the medicine, so that the problem that the effective bioactive ingredients in the silver strip raw material are easily damaged or lost, the preparation difficulty is increased and the like can be avoided, the pertinence is high, and the medicinal substance retention is good.
4. The preparation process of the invention aims at the processing and preparation of the effective components in the silver strips, develops functional medicated diet articles containing various effective medicinal components, improving the intestinal environment and adjusting the intestinal tract, provides a new method for the application of the silver strips in the aspect of traditional Chinese medicine, fully develops and utilizes the green, natural and rich-nutrition silver strips, widens the application of the silver strips in medical health care clinic, improves the additional value of the silver strip products, promotes the virtuous cycle of industry, has good economic and social benefits, and meets the requirement of the innovation and development of the traditional Chinese medicine. Is beneficial to changing the dietary structure and the health condition of people and has profound significance for improving the health level of people.
Detailed Description
The present invention will be described in further detail with reference to examples, but the scope of the present invention is not limited thereto.
Studies in the prior art have shown that: traditional Chinese medicine has great advantages in treating constipation, and the method is diversified. In traditional Chinese medicine formulas for treating constipation, the constipation is difficult to treat without using purgatives since ancient times. Indicating that cold-cool purgative herbs are an important part in treating constipation. However, if the chronic constipation patient uses cold-cool cathartic for a long time, the body fluid is easily damaged and the liquid is consumed, and the cold-cool can damage the spleen and stomach, which can cause intestinal diseases such as colonic paralysis, large intestine melanosis, irritable bowel syndrome and the like for a long time. Therefore, it is urgent to find a medicine and method for treating constipation. For years, the traditional Chinese medicine inherits the traditional Chinese medicine holism concept of treating chronic diseases and preventive diseases, treats based on syndrome differentiation, mainly treats constipation by medicated diet, and explores a new method for treating both principal and secondary aspects of constipation and protecting intestines and relaxing bowels.
Modern researches show that the stachyose is a vegetable with the highest stachyose content, and the stachyose is a naturally-occurring tetrasaccharide, and has a simple structure of fructose-glucose-galactose, a molecular formula of C24H42O21 and a relative molecular weight of 666.59. The saccharide is functional oligosaccharide, can completely enter colon without hydrolysis of digestive enzyme, and is hydrolyzed by intestinal bacteria, and has effects of promoting proliferation of Bacillus bifidus, lowering intestinal pH, promoting intestinal peristalsis, and improving intestinal function.
The invention provides a silver strip powder product and develops application of the silver strip powder product in medicines with the function of promoting or improving intestinal functions. The preparation process adopts fresh silver strips as raw materials and is matched with a multi-step and orderly processing treatment process to prepare the silver strip powder with remarkable medicinal function. The silver strip powder can be used alone or in combination with other medicines with intestinal function improving effect, and can be made into various oral dosage forms such as decoction, powder, pill, granule, and oral liquid by conventional preparation method. The other compound medicines comprise at least one of Tremella, semen Sesami, radix Panacis Quinquefolii, Ginseng radix, radix astragali, Poria, Atractylodis rhizoma, rhizoma Dioscoreae, radix Et rhizoma Fagopyri Tatarici, fructus Hordei Germinatus, testa Tritici, semen lablab album, fructus Jujubae, cortex Choerospondiatis, semen Persicae, fructus Amomi, semen Myristicae, arillus longan, fructus Lycii, thallus laminariae, endothelium corneum Gigeriae Galli, fructus Hippophae, and lalang grass rhizome.
The preparation method takes the silver strips as raw materials, and prepares the raw materials suitable for the application of the traditional Chinese medicine composition through the preparation process of the patent. Then, the selectivity of the intestinal tract to the active ingredients such as stachyose in the silver strips is utilized to screen out a silver strip powder formulation which is suitable for intestinal tract digestion and utilization, a use method, a use amount and the like, so as to achieve the purposes of increasing the intestinal nutrition, improving the intestinal environment and recovering the intestinal function by the active ingredients such as stachyose in the silver strips.
The invention relates to a silver bar product which is obtained by screening natural plants and has the function of definitely improving the intestinal function, and widens the application of silver bar powder in medical care clinic. The product can improve intestinal environment, promote intestinal function, relieve and prevent injury of intestinal dysfunction to human body, and improve symptoms, and is suitable for patients with functional intestinal diseases and complications such as constipation, large intestine melanosis, irritable bowel syndrome, etc. The application of the Chinese medicinal composition of the silver strip powder has the basic characteristics of large formula, large amount, wide range, mild tonification and mild regulation, body resistance strengthening and pathogenic factor eliminating, and prevention and treatment, has no obvious toxic or side effect in application, effectively improves the intestinal environment, and solves the problems of functional digestive tract diseases and the like.
The invention relates to a preparation process of silver strip powder for a traditional Chinese medicine composition, which comprises the following steps of material selection, cleaning, selection, blanching, drying, crushing, sieving, packaging, inspection, packaging and warehousing, and the preparation process comprises the following specific steps:
s1 material selection: the underground rhizomes of the silver strips are selected, the underground rhizomes of the silver strips are fine in texture, white like silver, thick, strong, free of breakage, hollow and free of impurities such as silt, the length of the underground rhizomes is generally more than 20cm, and the underground rhizomes of the silver strips are smooth and crisp due to fresh quality of the silver strips, are easy to break and are not suitable for long-term storage (easy to yellow, shrivel and decay and deterioration after long-term storage). The mixing of empty and deteriorated silver strips is forbidden to influence the quality.
S2, cleaning: the fresh silver strips are easy to be adhered with soil, sand and stone and inedible foreign matters. Uniformly spreading fresh silver strips on a cleaning machine, starting the cleaning machine for three groups, wherein the virtual height is not more than 5 cm. The silver strips are continuously flushed by the high-pressure spray head and then put in clean water to be thoroughly flushed. The silver strips are cleaned by clear water, the quality is ensured, and the silver strips are pure, white and jade for medicinal use.
S3, selecting: and (4) manually selecting the cleaned silver strips, and removing dry heads, tender heads, impurities and deformed silver strips. Yellow head, bad head and sundries are not needed, the silver strips are not too short, and the length is generally more than 20 cm.
S4 blanching: the silver strip in blanching water the in-process, require "the pot is clean, the water is wide, the fire is vigorous", heat the clear water in the pot to boiling and roll, then put into the silver strip of sanitization to in time turn over, the silver strip of blanching water the in-process keeps the complete form of silver strip as far as possible, make contact water and heated area reduce. The blanching time is controlled, and the nutrient components are lost along with the discharge of a large amount of water if the blanching time is too long due to the fact that the silver strips are crisp and tender and contain more water. Blanching the crisp and tender silver strips, preferably slightly rolling after blanking, and taking out after blanching for 1-2 min. If the time exceeds 2 minutes, the water-solubility of the silver strips (such as vitamin C) and other nutritional ingredients can be lost, and even the medicinal effect of the silver strips can be lost. The scientific blanching method can remove oxalic acid, peculiar smell, astringent taste and the like of the silver strips and can protect the medicinal efficacy of the silver strips.
S5, drying: and (4) putting the silver strips which are blanched, cooled and cooled into a drying dehumidifier for drying, wherein the silver strips are preferably placed in 2-5 layers. The drying temperature is 40-80 ℃, and the drying time is 5-12 h. The following problems are noted in the drying process:
(1) the silver strips are not overlapped on the steel wire mesh grid to be too thick or uneven in thickness.
(2) The drying time or temperature should be adjusted according to the texture and humidity of the silver strips. If the drying temperature is lower than 30 ℃, the time consumption is too long and the power consumption is large; the dried silver strips are easy to shrink and deteriorate after a long time at the drying temperature of higher than 80 ℃, and the bioactive components of the silver strips are damaged. Therefore, the control of the drying time and temperature of the silver strips is an important step for the silver strips to have attenuated survivability and maintain the medicinal efficacy.
S6, crushing: and putting the dried silver strips into a grinder for grinding.
S7, sieving: sieving the crushed silver bar coarse powder by a third-mesh sieve (50 meshes), then putting the obtained crude product on the sieve into a second-mesh sieve (24 meshes) for sieving, and taking the sun-dried 24-50 meshes of fine powder. The prepared silver bar powder which is suitable for preparing the traditional Chinese medicine composition and has relatively uniform granularity is obtained. The silver strip powder does not contain dietary fiber and is easy to be digested and utilized in intestinal tracts, so the silver strip powder required by the preparation process of the traditional Chinese medicine composition is not too coarse or too fine. If the particle size is larger than 24 meshes, it should not be used; being smaller than 50 meshes, the silver bar not only can damage the effective components of the silver bar and influence the efficacy of the silver bar, but also can increase the preparation difficulty.
S8, packaging, inspecting, packaging and warehousing: sterilizing the silver strip powder according to the preparation requirement, and quantitatively sealing and packaging; carefully inspecting the prepared finished silver strip powder, and coding, labeling, packaging and warehousing qualified products.
The clinical test application of the silver strip powder for the traditional Chinese medicine composition prepared by the preparation process of the invention is as follows:
1. application of silver strip powder for Chinese medicinal composition in treating constipation (deficient constipation):
constipation is a common disease, which is classified into excess and deficient. The actual secret is divided into heat secret, gas secret and cold secret; deficient constipation is also classified into qi deficiency, blood deficiency, yin deficiency and yang deficiency. Constipation, "chronic disease is mostly deficient", the deficient constipation is the most common type of constipation, accounting for more than 90% of constipation. We observed in the clinic that: the deficient syndrome is caused by improper diet, stagnation of qi, deficiency of qi, blood, yin and body fluids, etc. The elderly and the weak are high-incidence people, women are obviously higher than men, and people who lack sports for a long time are obviously higher than those who do frequent sports. Treatment principle of deficient constipation: replenishing qi to invigorate the spleen, and loosening the bowel to relieve constipation.
In the treatment, the Chinese medicinal composition No. 1 of the silver bar powder is used, and the formula is as follows: 10-20 parts of silver strip powder, 6-10 parts of tremella, 10-30 parts of astragalus, 3-5 parts of American ginseng, 10-20 parts of sesame and 20-40 parts of wheat bran, and the raw materials are added and reduced according to the disease condition, and are prepared into powder according to the method, the powder is decocted lightly, the powder is taken before meals, 15-30 g is taken each time, the powder is taken 2-3 times a day, and 3 months are a treatment course. In recent years, 100 patients with constipation (deficient constipation) are treated, 39 patients are cured, 61 patients are improved, and the effective rate is 100%.
Typical cases are: a certain Liu is a female with age of 44, suffering from constipation for more than 20 years, and the doctor can see a doctor in 2013. The study pressure is high in the high school, breakfast is rarely eaten, exercise is little, drinking water is little, fruit and vegetable are rarely eaten, medical treatment is carried out at four places after constipation occurs, various cathartics are taken, and the effect is not good enough. Defecation is usually carried out for 1 time in 7-8 days, and sometimes no defecation is carried out for 10 days, and enema is carried out. The dry stool is like a Chinese chestnut, difficult to defecate, short breath due to sweating and hypodynamia after defecating when the people struggle with strength and anger. Dizziness, blurred vision, pale complexion, lassitude, tired limbs and no desire to speak. No bloody pus and stool, and menopause for more than 4 years. Examination of enteroscopy at the time of arrival, routine of blood, urine, feces, etc.: no obvious abnormality was observed. Checking: a pale tongue with white coating and a weak pulse. Constipation (qi deficiency). The pathogenesis of the disease is that the patient has long-term improper diet, emotional disorder, deficiency of qi and blood and the like, so that the spleen and lung qi is deficient, the intestinal tract is not good, and the transportation and transformation are disordered. The treatment principle is as follows: replenishing qi to invigorate the spleen, and loosening the bowel to relieve constipation. A Chinese medicinal composition 1 is prepared from herba Lobeliae chinensis powder, Tremella, radix astragali, radix Panacis Quinquefolii, semen Sesami, and testa Tritici by making into powder according to the disease condition, decocting, and taking 15-30 g before meal for 2-3 times daily. During the treatment period, patients are instructed to avoid taking cooling drugs and laxatives for a long time, and attention is paid to basic therapy (reasonable diet, proper exercise, psychological balance) and other prevention. After 1 treatment course, the patient's dizziness, face whitish and tired, limb tired and lazy speaking etc. condition are obviously improved, can defecate smoothly 1 time every 1-2 days, occasionally the excrement is dry and hard, unfavorable. After 3 treatment courses, the patients feel good overall, and the constipation is cured. The defecation condition is normal after many years of follow-up visits.
2. The application of the silver strip powder used for the traditional Chinese medicine composition in treating chronic constipation and rectal melanosis comprises the following steps:
colonic Melanosis (MC) refers to a lesion characterized by mucosal pigmentation of lipofuscin-like substances in macrophages in the lamina propria of the colon, and since 1928 it was suggested that MC was associated with active or passive oral administration of anthraquinone purgative agents, chronic constipation and long-term oral administration of anthraquinone purgative agents were currently recognized as major causes of MC.
The causes and physiological and pathological changes of MC and Rectal Melanosis (RM) are basically the same, and the RM is mostly clinically included in the MC category. Literature systems are less studied. RM occurrence is also associated with chronic constipation and/or administration of anthraquinone laxatives, with the longer the administration time, the higher the RM incidence.
The prescription of using the silver bar powder traditional Chinese medicine composition No. 2 for treating constipation and rectal melanosis is as follows: 10-20 parts of honeysuckle, 10-20 parts of poria cocos, 10-20 parts of fried Chinese yam, 10-15 parts of fried bighead atractylodes rhizome, 20-40 parts of fried wheat bran and 5-15 parts of peach kernel, which are added according to the disease condition, and are prepared into powder by following the method, and the powder is decocted lightly and taken before meals, 20 g for each time and 3 times per day.
From 5 months to 8 months in 2013, 734 patients with chronic constipation are selected and subjected to clinical research of anoscopy diagnosis of chronic constipation and rectal melanosis, wherein 291 cases of men and 443 cases of women are aged 18-95 years and the disease course is 5 months-52 years. The main clinical symptoms include constipation, abdominal distension, difficult defecation, incomplete defecation and the like. Patients have long-term history of oral administration of rhubarb, senna leaf, aloe capsule, phenolphthalein tablet and the like, and the administration time is 2 months to 27 years. Of 734 patients with chronic constipation, RM138 patients were examined, with a detection rate of 18.8% (our research paper: Zhao Stand week, Zhao Jie, Nianlong Qi. anal gloscopy diagnosis of chronic constipation rectal melanosis clinical value [ J ]. J. anorectal J. in 2020, Vol. 40, No. 6: 51-52.). Meanwhile, the study on the treatment of the traditional Chinese medicine composition silver strip powder is carried out on 80 chronic constipation RM patients, and the study result shows that: the traditional Chinese medicine composition silver strip powder has a good effect of treating chronic constipation RM, and the effective rate is 100%.
Typical cases are: li Yi, Neu, 29 years old. The self-complaint cause is unknown and constipation occurs for more than 15 years. In the first two years, the patient defecates 1 time in 3-5 days without attention, and then becomes obese obviously due to constipation and weight increase. For treating constipation and obesity, the traditional Chinese medicine and western medicine are required for a plurality of places, and the effect is still not good. The patient can regulate himself and control diet without eating breakfast, egg and meat food for a long time. The laxative such as weight reducing tea, GUOSHUANG tablet, Aloe capsule, SIXIAO pill, SANHUANG tablet, and folium sennae is often administered alternately. In 2016, due to physical tiredness and hypodynamia, abdominal distension and discomfort and difficult defecation, the excrement is dry like sheep manure, and 40-60 minutes of defecation is carried out each time, and the excrement can not be discharged without laxatives, so that the life and the work are seriously influenced. The result of colonoscopy in certain Western's Ann hospital is the melanosis of colon. The doctor of 7 months of the old in 2017 introduces the doctor to see a doctor in the future; the examination and diagnosis by using an anoscope and the like are as follows: chronic constipation and rectal melanosis. A Chinese medicinal composition No. 2 in the form of powder for treating constipation and rectal melanosis comprises herba Vermilion, Poria, rhizoma Dioscoreae preparata, Atractylodis rhizoma preparata, testa Tritici preparata, and semen Persicae, and is prepared into powder by adding and subtracting according to the disease condition, and decocting lightly, wherein the powder is taken 20 g before meal, 3 times per day. When in treatment, the patient is instructed to insist on long-term comprehensive treatment, the diet is reasonable, the nutrition is comprehensive, three meals a day and breakfast are considered. Avoid taking anthraquinone (such as radix et rhizoma Rhei, Aloe, folium sennae, etc.) medicine, cold and cool cathartic, and weight reducing tea, etc., to avoid affecting recovery of intestinal function and health. The treatment of 9 months with the method can improve diet, mental status, defecation, etc. And (3) rechecking the colonoscope and the anoscope: no obvious abnormality was observed. The intractable constipation, the large intestine melanosis and the like of the plum are all reported to be cured, and no relapse is seen after 5 years of follow-up visit.
3. Use of silver bar powder for a Chinese medicinal composition for the treatment of irritable bowel syndrome:
irritable bowel syndrome (irritable bowel syndrome IBS) is one of the most common functional bowel disorders in the clinic, and changes to a main feature with repeated onset abdominal pain and defecation habits associated with defecation. Is one of the most common digestive tract diseases, and the prevalence rate in China is 7 to 12 percent. According to the main clinical manifestations of IBS, the names of the traditional Chinese medicine belong to the categories of constipation, diarrhea and abdominal pain. Weakness of the spleen and the stomach and/or liver dysfunction are important links of IBS pathogenesis, liver depression and spleen deficiency are important mechanisms of IBS pathogenesis, spleen and kidney yang deficiency and deficiency-excess inclusion are key factors of difficult disease recovery, no specific therapeutic drug exists at present, and IBS treatment is limited to symptomatic treatment.
In recent decades, we continuously learn to explore the effect of applying traditional Chinese medicine medicated diet therapy to IBS (relevant research papers: Zhao standing week, Li Xiao Yan, Houming month, etc. for the prescription of "Jiu Du kang-10" for treating irritable bowel syndrome clinical experience, Chinese medicated research conference, the first medicated conference, Beijing, 2021, the discussion of the academic seminal collection of Chinese medicated diet 2021 for 10 months and 529 + 531.), and the research of applying the traditional Chinese medicine composition silver bar powder to treat IBS, and have obtained certain achievements.
The prescription of the silver bar powder traditional Chinese medicine composition No. 3 for treating IBS is as follows: 10-20 parts of silver strips, 10-20 parts of tartary buckwheat, 10-15 parts of white hyacinth beans, 3-10 parts of endothelium corneum gigeriae galli, 10-15 parts of rice sprouts, 3-10 parts of sea buckthorn, 3-6 parts of fructus amomi, 3-10 parts of nutmeg and the like.
Typical cases are: somebody, woman, age 33. Postpartum abdominal pain and abdominal distension, constipation and diarrhea alternate for 7 years. Frequent insomnia and dreamful sleep, tiredness and hypodynamia, dysphoria, no dinner, preference for cold and uncooked snacks, abdominal pain and abdominal distension. Defecation is performed for 1 time in 3-4 days, and the stool is dry and hard, small in quantity, difficult to defecate, hard to do, urgent in defecation and unclean in defecation; sometimes, the defecation is 1-5 times a day, the stool is thin paste or soft and formed, and bloody stool is not purulent. The treatment is carried out by applying levofloxacin, tinidazole, mesalazine, probiotics, prebiotics and the like, and intestinal infectious diseases, tumor diseases and the like are eliminated by examining abdominal ultrasound, colonoscopy, excrement routine and the like in Luoyang hospital in 11 months in 2012. When irritable bowel syndrome is diagnosed, the pill for reinforcing spleen and benefiting intestine, the pill for tranquilizing mind, the pill for regulating middle warmer of aconite and the decoction of traditional Chinese medicine are applied to treat more than 1 year, and the curative effect is poor. The patients are diagnosed 6 months ago in 2014, intestinal infectious diseases and organic lesions of the patients are eliminated through further examination, and irritable bowel syndrome is diagnosed. The composition No. 3 is used for treating IBS, and the prescription comprises silver strips, tartary buckwheat, white hyacinth beans, endothelium corneum gigeriae galli, rice sprouts, sea buckthorn, fructus amomi, nutmeg and the like, and is modified according to the following syndrome. The patient is instructed to keep good mood for a long time while treating, three meals are reasonable, and the timing and the quantification are carried out. Unhealthy food is prohibited. The disease condition of the patient is obviously improved after the treatment of 2 months by the method. The disease is cured after continuous nursing and consolidation treatment for 3 months. In recent years, a certain period of regular follow-up is satisfied with the treatment effect.
The silver strips are plants with wide prospects in the aspects of development and utilization of medicines and health-care foods. The method can provide the added value of agricultural products, develop the market of agricultural products, promote the production enthusiasm of farmers and become a new income-creating industry for increasing the income of farmers. The silver strips can increase the income of farmers by 5000 plus 10000 yuan per mu.
The stachyose and the nutrient substances of the wild edible plant of the honeysuckle are rich, and the pH value of the intestinal tract can be reduced after the wild edible plant is used, so that the environment of the intestinal tract is improved, and the peristalsis of the intestinal tract is enhanced, thereby achieving the effect of reducing the absorption of ammonia in the intestinal tract. The silver strips can improve energy, promote multiple bifidobacteria in vivo to multiply, reduce ammonia substances such as indole in intestinal tract, and reduce endotoxemia. Meanwhile, the silver strips have the functions of tonifying, resisting aging and the like and can promote the health of the organism. The silver strip powder can be widely applied to food processing and medical care. The application of the Chinese medicinal composition, namely the silver strip powder, in preventing and treating digestive system diseases such as chronic constipation, large intestine melanosis, irritable bowel syndrome and the like, and chronic diseases such as hyperlipidemia, diabetes and the like is expected to obtain good application prospects. We should continue to study and utilize the function of silver strips and products thereof to broaden the application range of silver strips in medical care, so that the silver strips of ' special vegetable varieties in China ', national geographical indication products ' and ' national original region protection ' benefit more people.
In conclusion, the silver strips have the medical care efficacy, and can be processed and prepared aiming at the silver strips to develop various effective novel blood fat reducing medicines and functional medicinal food products for improving the intestinal environment and adjusting the intestinal tract. Can create a new method for the application of the silver strips in the aspect of traditional Chinese medicine. The patent mainly researches the development and utilization of the traditional Chinese medicine composition on the silver strips, improves the added value of the product, promotes the virtuous cycle of the industry, and has good economic and social benefits. The developed silver strips meet the national industrial policy, the direction of promoting novel agriculture and industrial and agricultural production and the requirement of innovation and development of traditional Chinese medicines. Is beneficial to changing the dietary structure and the health condition of people and has profound significance for improving the health level of people.

Claims (10)

1. The preparation process of the silver strip powder for the traditional Chinese medicine composition is characterized by comprising the following steps of:
(1) selecting materials
Selecting thick, hollow and fracture-free fresh underground silver strip rhizomes as raw materials;
(2) cleaning the substrate
Spreading the silver strip raw material selected in the step (1) on a cleaning machine, and cleaning the silver strip raw material in a continuous flooding washing mode to ensure that the surface of the silver strip raw material is clean and free of impurities;
(3) and refining
Manually picking and detecting the silver strips cleaned in the step (2), and removing bad heads, yellow heads, dry heads, tender heads, impurities and deformed silver strips;
(4) blanching the water
Blanching the silver strips selected in the step (3) in boiling water for 1-2min, continuously turning over the silver strips in the blanching process, and immediately taking the silver strips out of the pot for cooling after the blanching treatment is finished;
(5) and drying the mixture
Placing the silver strips cooled in the step (4) in a drying dehumidifier, controlling the drying temperature to be 40-80 ℃, and performing drying treatment for 5-12h to obtain a dry silver strip product with the water content not higher than 12% for later use;
(6) pulverizing the above materials
Putting the dried silver strips prepared in the step (5) into a grinder for grinding;
(7) and sieving the mixture
Sieving the silver strips crushed in the step (6) to obtain silver strip powder with the fineness of 24-50 meshes for later use;
(8) and a package
And (4) sterilizing the silver strip powder prepared in the step (7), sealing and packaging, and after the silver strip powder is qualified through inspection, printing a code, labeling and warehousing to obtain the finished silver strip powder for the traditional Chinese medicine composition.
2. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: in the step (1), the length of the underground rhizome of the fresh silver strip is not less than 20 cm.
3. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: and (3) in the step (2), cleaning the silver strip raw material spread on the cleaning machine by using a high-pressure spray head.
4. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: in the step (2), the height of the silver strip raw material spread on the cleaning machine is not more than 5 cm.
5. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: in the step (4), in the blanching treatment process, after the silver strips are put into the pot, the water temperature in the pot should be kept at 90-96 ℃, and the water in the pot should be capable of completely immersing the silver strips.
6. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: in the step (5), 2-5 layers of silver strips are uniformly spread on the steel wire meshes in the process of drying the silver strips in a drying dehumidifier.
7. The silver bar powder for a Chinese medicinal composition prepared using the process for preparing a silver bar powder for a Chinese medicinal composition according to any one of claims 1 to 6.
8. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: the obtained silver strip powder can be made into decoction, powder, pill, granule or oral liquid.
9. The process for preparing silver strip powder for a Chinese medicinal composition according to claim 1, wherein: the prepared silver strip powder for the traditional Chinese medicine composition can be compounded with at least one of tremella, sesame, American ginseng, astragalus, poria cocos, bighead atractylodes rhizome, Chinese yam, tartary buckwheat, malt, wheat bran, white hyacinth bean, black date, wild jujube, peach kernel, fructus amomi, nutmeg, arillus longan, wolfberry fruit, kelp, endothelium corneum gigeriae galli, sea buckthorn and lalang grass rhizome to prepare decoction, powder, pills, medicinal granules or oral liquid for use.
10. The application of the silver strip powder for the traditional Chinese medicine composition in a traditional Chinese medicine prescription for constipation, large intestine melanosis or irritable bowel syndrome.
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