CN114848767A - Herbal fermented traditional Chinese medicine nursing patch and preparation method thereof - Google Patents
Herbal fermented traditional Chinese medicine nursing patch and preparation method thereof Download PDFInfo
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- CN114848767A CN114848767A CN202210510467.5A CN202210510467A CN114848767A CN 114848767 A CN114848767 A CN 114848767A CN 202210510467 A CN202210510467 A CN 202210510467A CN 114848767 A CN114848767 A CN 114848767A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract
The invention discloses a herbal fermented traditional Chinese medicine nursing patch and a preparation method thereof, wherein the method comprises the following steps: step 1, selecting medicinal raw materials; step 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, inoculating a probiotic bacteria liquid, and performing solid state fermentation; step 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation; step 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane; step 5, repeatedly extracting the filtered residual solid product, and mixing the obtained extracting solution; step 6, heating the filtrate and the extracting solution to evaporate the solvent; and 7, processing the obtained product into the traditional Chinese medicine health-care patch. The invention also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method. The invention adopts special fermentation and extraction processes to enhance the drug property, the obtained maintenance patch is convenient to use, and the drug effect of the maintenance patch is far superior to that of the existing similar products through transdermal absorption by external application.
Description
Technical Field
The invention relates to a traditional Chinese medicine nursing patch and a preparation method thereof, in particular to a herbal fermented traditional Chinese medicine nursing patch and a preparation method thereof.
Background
The Chinese medicine is mainly composed of plant medicine (root, stem, leaf and fruit) and mineral medicine. Since the plant herbs account for the majority of the Chinese herbs, the Chinese herbs are also called Chinese herbs. The Chinese herbs used in various regions are thousands of, and the prescription formed by combining various herbs is rather numerous. Through thousands of years of research, an independent science, namely materia Medica, is formed.
Chinese herbal medicines are unique medicines used for preventing and treating diseases in the traditional Chinese medicine and are also important marks which are distinguished from other medicines in the traditional Chinese medicine. The curative effect of Chinese herbal medicine is more and more emphasized in the world, like Chinese acupuncture and moxibustion, and Chinese herbal medicine decoction are deep all over the world, but Chinese traditional medicine has many different plasticity for us with research, Chinese traditional medicine is generally brewed by two methods, one is to decoct and decoct according to a prescription given by a Chinese medicine expert, the other is to prepare medicinal liquor by soaking, and the two methods have much research in China. China is the origin of Chinese herbal medicines, and about 12000 medicinal plants are in China, which are not available in other countries and occupy monopoly advantages in Chinese herbal medicine resources. The ancient Xixian's deep exploration, research and summary of Chinese herbal medicine and Chinese medicine, so that the Chinese herbal medicine has been most widely recognized and applied.
However, the modern application technology for Chinese herbal medicines has many problems. Most of the traditional Chinese medicinal materials and products prepared from the traditional Chinese medicinal materials on the market are not subjected to processes such as scientific extraction and fermentation, medicinal components cannot be effectively refined, endless formulas exist, the component proportions are different, an optimized scheme is not provided, and the serious defect that the medicinal properties of the traditional Chinese medicinal materials in the products cannot be furthest exerted is caused.
Disclosure of Invention
The invention aims to provide a formula and a preparation process of a traditional Chinese medicine curing patch, which can solve the existing problems, and the medicine property is enhanced by adopting a special fermentation and extraction process, so that the obtained curing patch is convenient to use, and the medicine effect of the curing patch is far superior to that of the traditional similar products through transdermal absorption by external application.
In order to achieve the above object, the present invention provides a preparation method of a herbal fermented traditional Chinese medicine health patch, wherein the preparation method comprises: step 1, selecting and weighing raw materials of all medicinal materials; step 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation; step 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation; step 4, after the fermentation is finished, filtering the fermentation product by adopting a filtering membrane, and reserving the obtained filtrate for later use; step 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution; step 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, and evaporating the solvent; and 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
The preparation method of the herbal fermented traditional Chinese medicine health care patch comprises the following steps of (1): radix Stemonae, herba Eupatorii, radix Angelicae Dahuricae, radix rehmanniae Preparata, herba Saussureae Involueratae, Carthami flos, Kochiae fructus, rhizoma Smilacis Glabrae, rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, caulis Spatholobi, fructus Cnidii, radix Angelicae sinensis, and Borneolum Syntheticum.
The preparation method of the herbal fermented traditional Chinese medicine health-care patch comprises the following medicinal raw materials, by weight, 10-14 parts of radix stemonae, 8-12 parts of herba eupatorii, 5-7 parts of radix angelicae, 6-9 parts of prepared rehmannia root, 2-5 parts of saussurea involucrate, 5-8 parts of safflower, 3-6 parts of fructus kochiae, 7-10 parts of rhizoma smilacis glabrae, 5-8 parts of ligusticum wallichii, 12-15 parts of salvia miltiorrhiza, 4-6 parts of caulis spatholobi, 3-5 parts of fructus cnidii, 8-10 parts of angelica sinensis and 7-9 parts of borneol.
The preparation method of the herbal fermented traditional Chinese medicine health patch comprises the step of carrying out fermentation treatment on the herbal fermented traditional Chinese medicine health patch, wherein the probiotics in the step 2 and the step 3 adopt yeast after enlarged culture.
In the preparation method of the herbal fermented traditional Chinese medicine health care patch, in the step 2, the granularity of the powdered medicinal material is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: (7-12), mixing bran, corn flour, urea, monopotassium phosphate and glucose to prepare a solid culture medium, adding purified water, adjusting humidity, and adding water to obtain a feed liquid with a mass ratio of 1: (0.8 to 1).
In the step 2, the solid fermentation is performed for 2-3 days at 27-30 ℃, and the bacterial liquid inoculum size of the probiotics accounts for 7-10% of the solid fermentation raw material by mass percent.
The preparation method of the herbal fermented traditional Chinese medicine health patch comprises the following steps of (1) adding purified water as a solvent in step 3, adding a brown sugar as a carbon source, and mixing the solid-state fermented product and the brown sugar with the purified water in a mass ratio of (60-80): (20-25): 1000, parts by weight; the bacterial liquid inoculation amount of the probiotics accounts for 0.5 to 1.5 percent of the liquid fermentation raw material in percentage by mass; the liquid fermentation is carried out for 5-7 days at the temperature of 28-35 ℃.
In the step 5, the adopted solvent is ethanol with a volume fraction of 70% -90%, the ethanol reflux method and ultrasonic treatment are combined, the extraction is repeated for 3-4 times, and the obtained extracting solutions are combined.
In the step 6 and the step 7, the solvent is evaporated by drying equipment until the product is viscous to obtain an ointment, and the ointment is filled into a patch carrier to prepare a traditional Chinese medicine nursing patch; or baking for 2 hours at the high temperature of 140 ℃ by drying equipment to evaporate all the solvent to dryness, crushing the obtained solid product into small granular medicinal powder with the granularity of 60-70 meshes, and finally filling the medicinal powder into a sanitary pad carrier to prepare the traditional Chinese medicine health-care pad patch.
The invention also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method.
The herbal fermentation traditional Chinese medicine nursing patch and the preparation method thereof provided by the invention have the following advantages:
the herbal fermented traditional Chinese medicine nursing patch obtained by the invention has a plurality of excellent functions, including: 1) cold dispelling and dampness eliminating, and is suitable for people with yin dampness and problems; 2) clearing and activating the channels and collaterals, and can relieve the problems of dysmenorrheal, cold uterus and the like; 3) expelling parasites and sterilizing, and relieving partial discomfort of gynecological inflammation; 4) the use is convenient, and the plaster can be used after being torn off.
This maintenance subsides still have other characteristics, include: 1) pure plant traditional Chinese medicinal materials are adopted, so that the medicine property is mild, and phenomena such as allergy and the like are not easy to generate; 2) no chemical agent is added, no preservative is added, and the quality guarantee period of 2-3 years is not deteriorated; 3) the effect of the percutaneous absorption medicinal materials is far better than that of the same type of products and the like.
The preparation method of the invention also has unique advantages, including: 1) the method adopts special fermentation and extraction processes to enhance drug properties; 2) the product is combined with daily health products, and is convenient to use; 3) it is administered topically without oral administration or internal application.
Detailed Description
The following further describes embodiments of the present invention.
The preparation method of the herbal fermentation traditional Chinese medicine health care patch provided by the invention comprises the following steps: step 1, selecting and weighing raw materials of all medicinal materials; step 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation; step 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation; step 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane, and obtaining filtrate for later use; step 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution; step 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, and evaporating the solvent; and 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
In the step 1, the medicinal materials comprise: radix Stemonae, herba Eupatorii, radix Angelicae Dahuricae, radix rehmanniae Preparata, herba Saussureae Involueratae, Carthami flos, Kochiae fructus, rhizoma Smilacis Glabrae, rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, caulis Spatholobi, fructus Cnidii, radix Angelicae sinensis, and Borneolum Syntheticum.
The raw materials of the medicinal materials are preferably calculated according to the parts by weight: 10-14 parts of radix stemonae, 8-12 parts of herba eupatorii, 5-7 parts of radix angelicae, 6-9 parts of prepared rehmannia root, 2-5 parts of saussurea involucrate, 5-8 parts of safflower, 3-6 parts of fructus kochiae, 7-10 parts of rhizoma smilacis glabrae, 5-8 parts of ligusticum wallichii, 12-15 parts of salvia miltiorrhiza, 4-6 parts of caulis spatholobi, 3-5 parts of fructus cnidii, 8-10 parts of angelica and 7-9 parts of borneol.
Wherein the radix Stemonae is dried root tuber of Stemonaceae plant such as Stemonae radix Stemonae, Stemonae radix or Stemonae folium. Sweet and bitter in flavor and slightly warm in nature. It enters lung meridian. Has the effects of moistening lung, descending qi, relieving cough, killing parasites and killing lice. It is commonly used for cough due to new or old age, cough due to tuberculosis, and cough due to lung stagnation; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus. Honey radix Stemonae can moisten lung to relieve cough, and can be used for treating cough due to yin deficiency.
Herba Eupatorii is the dried aerial part of Eupatorii chinensis of Compositae. Cutting in summer and autumn twice, removing impurities, and sun drying. Pungent flavor and mild property. It enters spleen, stomach and lung meridians. Has the functions of eliminating dampness with aromatics, activating spleen, stimulating appetite, relieving exterior syndrome and relieving summer-heat. Can be used for treating damp obstruction in middle energizer, gastric fullness, emesis, halitosis, excessive salivation, summer-heat, damp exterior syndrome, fever, listlessness, and chest distress.
The angelica dahurica is a perennial tall herb plant, contains rich protein fat, carbohydrate and trace elements, has high medicinal value, can expel wind and dissipate dampness, expel pus, promote tissue regeneration and relieve pain when used as a medicament, and mainly treats diseases such as wind-cold type common cold, forehead headache, nasosinusitis, toothache, anal fistula, hematochezia, leucorrhea, carbuncle-abscess pyogenic infections, burn and the like.
The radix rehmanniae Preparata is rhizome of Scrophulariaceae plant rehmanniae radix or rehmanniae radix, and is prepared by processing, steaming and drying. Sweet and mild in nature and taste, enters liver and kidney meridians, and has effects of replenishing blood and yin, replenishing essence and marrow, and can be used for treating deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat and nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, palpitation, menoxenia, metrorrhagia, metrostaxis, tinnitus, and premature gray hair.
Herba Saussureae Involueratae is dried aerial part of herba Saussureae Involueratae of Compositae. Mainly produced in Xinjiang. Collected in summer and autumn when blooming, and dried in the shade. Slightly bitter taste and warm nature. Enter liver, spleen and kidney meridians. Has the effects of warming kidney, supporting yang, dispelling pathogenic wind, eliminating dampness, dredging channels, and promoting blood circulation. Can be used for treating arthralgia due to wind-cold-dampness, rheumatoid arthritis, lower abdomen psychroalgia, and menoxenia.
The Carthami flos is dried flower of Carthamus Tinctorius of Compositae. Collected in the shade or dried in the sun when the flowers turn yellow and red in summer. The cultivation is widely carried out all over the country. Pungent flavor and warm nature. It enters heart and liver meridians. Has the functions of promoting blood circulation to restore menstrual flow, eliminating blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.
Kochia scoparia is dried mature fruit of Kochia scoparia of Chenopodiaceae. Harvesting plants in autumn when the fruits are mature, drying in the sun, removing the fruits and removing impurities. Pungent and bitter in flavor and cold in nature. It enters kidney and bladder meridians. Has the effects of clearing heat, promoting diuresis, dispelling pathogenic wind and relieving itching. Mainly treats difficult and painful urination, pruritus vulvae, leukorrhagia, rubella, eczema and skin pruritus.
Rhizoma Smilacis Glabrae is dried rhizome of Smilax scobinicaulis of Liliaceae, and is perennial evergreen climbing shrub, which is mostly grown in hillside or under forest. The part for medicine is only selected from dried rhizome. Collected in summer and autumn, removed fibrous root, cleaned, dried and used as medicine; or cutting into slices, drying, and making into medicine. Sweet and bland in flavor and mild in nature. It enters liver and stomach meridians. Has the effects of removing toxic substances, eliminating dampness, and relieving joint pain, and is mainly used for treating limb spasm and arthralgia and myalgia caused by syphilis and mercury poisoning; stranguria with turbid pathogen due to damp-heat, leukorrhagia, abscess, scrofula, scabies and tinea.
Rhizoma Ligustici Chuanxiong is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong; digging in 5 months, removing silt, drying in the sun, and removing fibrous root. Sliced, unprocessed or stir-baked with wine. Pungent and warm in nature and taste; entering liver, gallbladder and pericardium; has the effects of promoting qi circulation, resolving stagnation, dispelling pathogenic wind, eliminating dampness, promoting blood circulation, and relieving pain; it can be used for treating wind-cold headache, vertigo, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stagnation, pain, carbuncle, cellulitis, and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Bitter and slightly cold in taste. It enters heart and liver meridians. Collected in spring and autumn, removed stem and leaf, cleaned, moistened, cut into thick pieces, and dried in the sun. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain. The Saviae Miltiorrhizae radix contains bioactive substances such as tanshinone, cryptotanshinone, isotanshinone, tanshinone, tanshinol, etc., and also contains vitamin A, E and metal elements such as ferrum and potassium. Tanshinone has female hormone-like function, and female hormone can reduce sebaceous gland and reduce sebum secretion.
Caulis Spatholobi is dry rattan of Spatholobus Suffruticosa of Leguminosae. Collecting caulis Seu folium Ampelopsis Brevipedunculatae in autumn and winter, removing branches and leaves and impurities, moistening thoroughly, slicing, and sun drying. Unprocessed or decocted to paste. Has bitter and slightly sweet taste and warm nature, enters liver, heart and kidney meridians, has the effects of promoting blood circulation, relaxing muscles and tendons, nourishing blood and regulating menstruation, is mainly used for treating rheumatic arthralgia, numbness of hands and feet, quadriplegia, irregular menstruation, unsmooth menstruation, dysmenorrheal, amenorrhea and leukopenia, and can be used for promoting blood circulation, removing blood stasis and replenishing blood.
Fructus Cnidii is named as wild carrot seed, and is dried mature fruit of cnidium monnieri (L.) DC of Umbelliferae. Pungent and bitter with warm nature. It enters kidney meridian. Has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, relieving itching, warming kidney and tonifying yang. Can be used for treating pruritus vulvae, leukorrhagia, eczema, pruritus, lumbago due to damp arthralgia, sexual impotence due to kidney deficiency, and infertility due to cold womb.
The radix Angelicae sinensis is dried root of Angelica sinensis (oliv.) Diels of Umbelliferae. Collected in late autumn, removed reed heads and fibrous roots, and bundled into small bundles according to size and thickness after water is slightly evaporated, and slowly dried by slow fire or smoked by sulfur, sliced for raw use for mothproof and mildew-proof purposes, or mixed with wine and fried with wine. Sweet, slightly bitter, slightly numb and pungent taste, sweet and pungent taste, warm nature. It enters liver, heart and spleen meridians. Has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation, resisting cancer, resisting aging, and enhancing immunity. It can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. Can be used for promoting blood circulation, removing blood stasis, and relieving constipation.
The Borneolum Syntheticum is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Colorless transparent or semitransparent flaky crisp crystals with faint scent; it is volatile, and can be ignited to produce thick smoke and flame with light. Contains Borneolum (not less than 55.0%). Pungent, bitter and slightly cold in nature. It enters heart, spleen and lung meridians. The product has effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substances, improving eyesight, and removing nebula, and can be used for treating hemorrhoid, fever, hyperpyrexia, coma, apoplexy, phlegm syncope, convulsion, summer-heat dampness covering resuscitation, pharyngitis, deafness, aphtha, swelling of teeth, skin ulcer, carbuncle, malnutritional hemorrhoid, conjunctival congestion, swelling and pain, nebula, and eye covering.
The raw materials are wild Chinese herbal medicines, and perennial Chinese herbal medicines are five years or more. The material is obtained from wild rare animals and plants, and can be artificially cultured and planted under the condition that conditions are not allowed, or other substitutes with equivalent and similar effects.
And (3) adopting the yeast after the enlarged culture as the probiotics in the step 2 and the step 3.
The granularity of the powdered medicinal material in the step 2 is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: (7-12), and mixing bran, corn flour, urea, monopotassium phosphate and glucose to prepare the solid culture medium. Wherein the corn bran corn starch is prepared from 50-55% of bran, 36-42% of corn flour, 0.6-0.7% of urea, 0.4-0.5% of monopotassium phosphate and 7-8% of glucose by mass percentage. And adding purified water, adjusting the humidity, wherein the mass ratio of the feed liquid after water is added is 1: (0.8-1), then carrying out sterilization treatment, and then carrying out probiotic inoculation.
The solid fermentation in the step 2 is carried out for 2-3 days at the temperature of 27-30 ℃, and the bacterial liquid inoculum size of the probiotics accounts for 7-10% of the solid fermentation raw material by mass percent.
The solvent added in the step 3 is purified water, the carbon source is brown sugar, and the mass ratio of the solid-state fermentation product to the brown sugar to the purified water is (60-80): (20-25): 1000, uniformly mixing, sterilizing, and inoculating probiotics; the bacterial liquid inoculation amount of the probiotics accounts for 0.5 to 1.5 percent of the liquid fermentation raw material in percentage by mass; the liquid fermentation is carried out in a large-scale boiler or a fermentation tank at the temperature of 28-35 ℃ for 5-7 days.
The aperture of the filtering membrane adopted in the step 4 is determined according to the molecular size of the effective components of the medicine, so that the corresponding filtering membrane is selected to fully retain the effective components of the medicine in the filtrate.
In the step 5, the mass-volume ratio of the extracted matter to the solvent is 1: (12-15), the adopted solvent is ethanol with the volume fraction of 70% -90%, the ethanol reflux method is matched with ultrasonic treatment, repeated extraction is carried out for 3-4 times, each time lasts for 30-45 min, and then the obtained extracting solutions are combined.
The ethanol reflux method is a method of extracting medicinal materials with volatile organic solvent such as ethanol, heating the extract, distilling the solvent, condensing and refluxing the solvent to the extractor, and extracting the medicinal materials repeatedly until the effective components are fully extracted.
In the step 6 and the step 7, evaporating the solvent by drying equipment until the product is viscous to obtain an ointment, and then filling the ointment into a patch carrier to prepare a traditional Chinese medicine curing patch; or baking for 2 hours at the high temperature of 140 ℃ by drying equipment to evaporate all the solvent to dryness, crushing the obtained solid product into small granular medicinal powder with the granularity of 60-70 meshes, and finally filling the medicinal powder into a sanitary pad carrier to prepare the traditional Chinese medicine health-care pad patch.
The equipment and other process conditions employed in the present invention are known to those skilled in the art.
The invention also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method.
The herbal fermented traditional Chinese medicine curing patch and the preparation method thereof provided by the invention are further described below with reference to the examples.
Example 1
A preparation method of a herbal fermented traditional Chinese medicine health-care patch comprises the following steps:
step 1, selecting and weighing raw materials of the medicinal materials.
Preferably, the raw materials of the medicinal materials are as follows by weight: 12 parts of radix stemonae, 10 parts of herba eupatorii, 6 parts of radix angelicae, 7 parts of prepared rehmannia root, 3 parts of saussurea involucrate, 6 parts of safflower, 5 parts of fructus kochiae, 8 parts of rhizoma smilacis glabrae, 7 parts of ligusticum wallichii, 14 parts of salvia miltiorrhiza, 5 parts of caulis spatholobi, 4 parts of fructus cnidii, 9 parts of angelica and 8 parts of borneol.
And 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation.
The granularity of the pulverized medicinal material raw materials is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: 7, mixing the solid culture medium with bran, corn flour, urea, monopotassium phosphate and glucose to prepare, adding purified water, adjusting humidity, and adding water to obtain a feed liquid with a mass ratio of 1: 0.8.
the solid-state fermentation process is to ferment for 2-3 days at the temperature of 27-30 ℃, and the bacterial liquid inoculum size of the probiotics accounts for 9% of the solid-state fermentation raw material by mass percent.
And 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation.
The added solvent is purified water, the carbon source is brown sugar, and the mass ratio of the solid-state fermentation product to the brown sugar to the purified water is 3: 1: 50; the bacterial liquid inoculation amount of the probiotics is 0.5 percent of the liquid fermentation raw material in percentage by mass. The liquid fermentation process is carried out for 5-7 days at the temperature of 28-35 ℃.
The probiotics inoculated in the solid fermentation and the liquid fermentation both adopt yeast after enlarged culture.
And 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane, and obtaining filtrate for later use.
And 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution.
The adopted solvent is ethanol with volume fraction of 70%, the ethanol reflux method is combined with ultrasonic treatment, the extraction is repeated for 4 times, each time is 30min, and the obtained extracting solutions are combined.
And 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, so that the solvent is evaporated.
And 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
Preferably, the solvent is evaporated by drying equipment until the product is viscous to obtain an ointment, and the ointment is filled into a patch carrier to prepare the Chinese medicinal nursing patch.
In the method, all the raw materials respectively accord with the corresponding national quality standards.
The embodiment also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method.
Example 2
A preparation method of a herbal fermented traditional Chinese medicine health-care patch comprises the following steps:
step 1, selecting and weighing raw materials of the medicinal materials.
Preferably, the raw materials of the medicinal materials are as follows by weight: 10 parts of radix stemonae, 8 parts of herba eupatorii, 5 parts of radix angelicae, 6 parts of prepared rehmannia root, 2 parts of saussurea involucrate, 5 parts of safflower, 3 parts of fructus kochiae, 7 parts of rhizoma smilacis glabrae, 5 parts of ligusticum wallichii, 12 parts of salvia miltiorrhiza, 4 parts of caulis spatholobi, 3 parts of fructus cnidii, 8 parts of angelica and 7 parts of borneol.
And 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation.
The granularity of the powdered medicinal material is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: 10, mixing a solid culture medium prepared by bran, corn flour, urea, monopotassium phosphate and glucose, adding purified water, adjusting humidity, and adding water to obtain a feed liquid with a mass ratio of 1: 0.9.
the solid-state fermentation process is to ferment for 2-3 days at the temperature of 27-30 ℃, and the bacterial liquid inoculum size of the probiotics accounts for 9.5% of the solid-state fermentation raw material by mass percent.
And 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation.
The added solvent is purified water, the carbon source is brown sugar, and the mass ratio of the solid-state fermentation product to the brown sugar to the purified water is 35: 11: 500, a step of; the bacterial liquid inoculation amount of the probiotics accounts for 1 percent of the liquid fermentation raw material in percentage by mass. The liquid fermentation process is carried out for 5-7 days at the temperature of 28-35 ℃.
The probiotics inoculated in the solid fermentation and the liquid fermentation both adopt yeast after enlarged culture.
And 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane, and obtaining filtrate for later use.
And 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution.
The adopted solvent is 80% ethanol by volume fraction, and the ethanol reflux method is combined with ultrasonic treatment, repeated extraction is carried out for 3 times, each time is 40min, and then the obtained extracting solutions are combined.
And 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, so that the solvent is evaporated.
And 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
Preferably, baking for 2 hours at the high temperature of 140 ℃ by a drying device to evaporate all the solvent, crushing the obtained solid product into small granular medicinal powder with the granularity of 60-70 meshes, and finally filling the medicinal powder into a sanitary pad carrier to prepare the traditional Chinese medicine health-care pad patch.
In the method, all the raw materials respectively accord with the corresponding national quality standards.
The embodiment also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method.
Example 3
A preparation method of a herbal fermented traditional Chinese medicine health-care patch comprises the following steps:
step 1, selecting and weighing raw materials of the medicinal materials.
Preferably, the raw materials of the medicinal materials in parts by weight are as follows: 14 parts of radix stemonae, 12 parts of herba eupatorii, 7 parts of radix angelicae, 9 parts of prepared rehmannia root, 5 parts of saussurea involucrate, 8 parts of safflower, 6 parts of fructus kochiae, 10 parts of rhizoma smilacis glabrae, 8 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 6 parts of caulis spatholobi, 5 parts of fructus cnidii, 10 parts of angelica sinensis and 9 parts of borneol.
And 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation.
The granularity of the powdered medicinal material is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: 12, mixing a solid culture medium prepared by bran, corn flour, urea, potassium dihydrogen phosphate and glucose, adding purified water, adjusting humidity, and adding water to obtain a feed liquid with a mass ratio of 1: 1.
the solid-state fermentation process is to ferment for 2-3 days at the temperature of 27-30 ℃, and the bacterial liquid inoculum size of the probiotics accounts for 10% of the solid-state fermentation raw material by mass percent.
And 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation.
The added solvent is purified water, the carbon source is brown sugar, and the mass ratio of the solid-state fermentation product to the brown sugar to the purified water is 16: 5: 200 of a carrier; the bacterial liquid inoculation amount of the probiotics accounts for 1.5 percent of the liquid fermentation raw material in percentage by mass. The liquid fermentation process is carried out for 5-7 days at the temperature of 28-35 ℃.
The probiotics inoculated in the solid fermentation and the liquid fermentation adopt the yeast after the enlarged culture.
And 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane, and obtaining filtrate for later use.
And 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution.
The adopted solvent is 90% ethanol by volume fraction, repeatedly extracting for 3 times (45 min each time) by ethanol reflux method in combination with ultrasonic treatment, and mixing the obtained extractive solutions.
And 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, so that the solvent is evaporated.
And 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
Preferably, baking for 2 hours at the high temperature of 140 ℃ by a drying device to evaporate all the solvent, crushing the obtained solid product into small granular medicinal powder with the granularity of 60-70 meshes, and finally filling the medicinal powder into a sanitary pad carrier to prepare the traditional Chinese medicine health-care pad patch.
In the method, all the raw materials respectively accord with the corresponding national quality standards.
The embodiment also provides the herbal fermented traditional Chinese medicine health-care patch prepared by the method.
The key point of the processing technology of the herbal fermentation traditional Chinese medicine health-care patch provided by the invention is the process of treating the medicinal materials in the adopted method, and the processing technology specifically comprises the following steps: cleaning, drying and pulverizing the medicinal materials, adding the medicinal materials into a solid culture substrate, uniformly mixing, adjusting the humidity, inoculating probiotic yeast, performing solid fermentation for 2-3 days, then adding a solvent, uniformly mixing, putting the obtained extract into a large boiler or a fermentation tank, adding purified water and a carbon source, inoculating probiotic yeast liquid subjected to expanded culture, performing liquid fermentation on the medicinal materials for 5-7 days, performing fine screening according to the molecular weight of the effective components of the medicaments by adopting a filter membrane for fermentation products, putting the filtered residual solid products into large equipment, repeatedly extracting through a solvent extraction method to excite the residual medicament properties, finally mixing the extracted products and the filtered filtrate, putting the mixture into drying equipment to evaporate the solvent to obtain an ointment, and finally putting the ointment into a patch carrier, preparing the traditional Chinese medicine nourishing paste; or baking the mixed solution at 140 deg.C for 2 hr, crushing the obtained solid product into small granular powder, and packaging the powder into sanitary pad carrier to obtain the final product.
The herbal fermented traditional Chinese medicine health-care patch prepared by the invention adopts special fermentation and extraction processes, enhances the medicine property, is combined with daily health-care products, is convenient to use, can be torn once and pasted once, does not need to be taken orally or used in vivo, and can ensure that the effect of percutaneous absorption of medicinal materials is far better than that of the same type of products through external application.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (10)
1. A preparation method of a herbal fermented traditional Chinese medicine health-care patch is characterized by comprising the following steps:
step 1, selecting and weighing raw materials of all medicinal materials;
step 2, cleaning, drying and powdering the medicinal materials, adding the medicinal materials into a solid culture medium, uniformly mixing, adjusting humidity, performing sterilization treatment, inoculating a probiotic liquid, and performing solid state fermentation;
step 3, adding a solvent into the solid-state fermentation product, supplementing a carbon source, uniformly mixing, adding the obtained mixed solution into a fermentation container, sterilizing, inoculating a probiotic bacterial liquid, and performing liquid-state fermentation;
step 4, after the fermentation is finished, filtering the fermentation product by using a filtering membrane, and obtaining filtrate for later use;
step 5, adding the filtered residual solid product into a solvent, performing repeated extraction by matching with ultrasound, and mixing the obtained extracting solution;
step 6, putting the filtrate obtained in the step 4 and the extracting solution obtained in the step 5 into drying equipment for heating, and evaporating the solvent;
and 7, processing the product obtained in the step 6 into the traditional Chinese medicine nursing patch, sterilizing, and finally packaging to obtain a finished product.
2. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 1, wherein in the step 1, the raw materials of the medicinal materials comprise: radix Stemonae, herba Eupatorii, radix Angelicae Dahuricae, radix rehmanniae Preparata, herba Saussureae Involueratae, Carthami flos, Kochiae fructus, rhizoma Smilacis Glabrae, rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, caulis Spatholobi, fructus Cnidii, radix Angelicae sinensis, and Borneolum Syntheticum.
3. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 2, wherein the raw materials of the medicinal materials comprise, by weight, 10-14 parts of radix stemonae, 8-12 parts of herba eupatorii, 5-7 parts of radix angelicae, 6-9 parts of prepared rehmannia root, 2-5 parts of saussurea involucrate, 5-8 parts of safflower carthamus, 3-6 parts of fructus kochiae, 7-10 parts of rhizoma smilacis glabrae, 5-8 parts of ligusticum wallichii, 12-15 parts of radix salviae miltiorrhizae, 4-6 parts of caulis spatholobi, 3-5 parts of fructus cnidii, 8-10 parts of angelica sinensis and 7-9 parts of borneol.
4. The method for preparing herbal fermented traditional Chinese medicine health patch according to claim 1, wherein the probiotics in the step 2 and the step 3 are yeast after enlarged culture.
5. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 1, wherein in the step 2, the granularity of the pulverized medicinal material is 30-50 meshes; the mass ratio of the medicinal raw materials to the solid culture medium is 1: (7-12), mixing bran, corn flour, urea, monopotassium phosphate and glucose to prepare a solid culture medium, adding purified water, adjusting humidity, and adding water to obtain a feed liquid with a mass ratio of 1: (0.8 to 1).
6. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 5, wherein in the step 2, the solid state fermentation is performed for 2-3 days at 27-30 ℃, and the bacterial liquid inoculation amount of the probiotics is 7-10% of the solid state fermentation raw material by mass percent.
7. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 1, wherein in the step 3, the added solvent is purified water, the carbon source is brown sugar, and the mass ratio of the solid-state fermented product to the brown sugar to the purified water is (60-80): (20-25): 1000, parts by weight; the bacterial liquid inoculation amount of the probiotics accounts for 0.5 to 1.5 percent of the liquid fermentation raw material in percentage by mass; the liquid fermentation is carried out for 5-7 days at the temperature of 28-35 ℃.
8. The preparation method of the herbal fermented traditional Chinese medicine health patch as claimed in claim 1, wherein in the step 5, the adopted solvent is ethanol with a volume fraction of 70% -90%, the ethanol reflux method and ultrasonic treatment are combined, the extraction is repeated for 3-4 times, and then the obtained extracting solutions are combined.
9. The method for preparing a herbal fermented traditional Chinese medicine nursing patch as claimed in claim 1, wherein in the steps 6 and 7, the solvent is evaporated by drying equipment until the product is viscous to obtain an ointment, and then the ointment is filled into a patch carrier to prepare a traditional Chinese medicine nursing patch; or baking for 2 hours at the high temperature of 140 ℃ by drying equipment to evaporate all the solvent to dryness, crushing the obtained solid product into small granular medicinal powder with the granularity of 60-70 meshes, and finally filling the medicinal powder into a sanitary pad carrier to prepare the traditional Chinese medicine health-care pad patch.
10. A herbal fermented traditional Chinese medicine health patch prepared by the method of any one of claims 1-9.
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| CN105709138A (en) * | 2016-04-17 | 2016-06-29 | 刘建强 | Nursing patch for genital disease treatment and genital healthcare |
| CN107625920A (en) * | 2017-10-11 | 2018-01-26 | 付金龙 | Gynaecology's gel and preparation method thereof |
| CN107998366A (en) * | 2018-02-06 | 2018-05-08 | 河南迪国科技发展有限公司 | It is a kind of suitable for Chinese medicine composition of puerpera's lactagogue at initial stage in postpartum and preparation method thereof |
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Application publication date: 20220805 |