CN114848717A - Aromatic south medicine compound essential oil and preparation method thereof - Google Patents

Aromatic south medicine compound essential oil and preparation method thereof Download PDF

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CN114848717A
CN114848717A CN202210359717.XA CN202210359717A CN114848717A CN 114848717 A CN114848717 A CN 114848717A CN 202210359717 A CN202210359717 A CN 202210359717A CN 114848717 A CN114848717 A CN 114848717A
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essential oil
oil
aromatic
parts
preparation
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CN114848717B (en
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潘利明
吴继婷
李颖琪
黄伟业
林铟潼
陈瑞松
张涧
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Guangdong Pharmaceutical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/01—Deodorant compositions
    • A61L9/013—Deodorant compositions containing animal or plant extracts, or vegetable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/20—Method-related aspects
    • A61L2209/21—Use of chemical compounds for treating air or the like
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the technical field of aromatic south medicine essential oil, discloses aromatic south medicine compound essential oil and a preparation method thereof, and particularly discloses compound essential oil which comprises the following components: clove essential oil, cinnamon essential oil, wrinkled gianthyssop essential oil, sandalwood essential oil and fingered citron essential oil. The aromatic south medicine composite essential oil provided by the invention does not contain essence, preservative and mineral oil, is pure, mild, safe and non-irritating, has round and mild smell, is comfortable, has costustoot flavor and fresh fruit flavor, has slight medicinal fragrance, and can be absorbed through mucous membranes such as nasal cavities, oral cavities and the like.

Description

Aromatic south medicine compound essential oil and preparation method thereof
Technical Field
The invention belongs to the technical field of aromatic south medicine essential oil, and particularly relates to aromatic south medicine compound essential oil and a preparation method thereof.
Background
Aromatic Chinese herbs refer to Chinese herbs that can emit strong aromatic odor from medicinal parts or generate aromatic odor after being burned and heated, and can be used for treating and preventing diseases, and are important parts of Chinese medicine clinical practice. The aromatic Chinese herbs have strong aromatic odor because they are rich in essential oils, which are also called volatile oils, and are a general term for a kind of volatile oily liquid that can be distilled with water vapor and is immiscible with water.
The essential oil of Chinese herbs usually has unique effects, such as relieving exterior syndrome, eliminating dampness, promoting qi circulation, inducing resuscitation, etc., and can act on local or whole body to prevent and treat diseases. The essential oil has mild action and small side effect, and has the functions of preventing infectious diseases, inhibiting bacteria, resisting inflammation, preventing corrosion, preventing and treating depression, resisting oxidation, promoting cell metabolism, cell regeneration and the like. The Chinese medicinal essential oil combines the pharmacological action of Chinese medicines with aromatherapy of Chinese medicine, and has wide application in medical treatment, health promotion, food, articles for daily use, etc. However, most of single essential oil has weak pharmacological action and single action, and may be more pungent and uncomfortable, and the single essential oil often cannot achieve the ideal effect. The compatibility of various essential oils can enhance the drug effect, play a synergistic role, cover and reduce the bad smell, and even generate the pharmacological action and specific smell which are not available in single essential oil, thereby expanding the application range of the essential oil.
The aromatic Chinese herbs in south medicine are called aromatic south herbs. Aromatic south herbs are a great treasury. In the south of Lingnan of China, in tropical and subtropical regions, the medicine is hot and rainy all the year round, the geothermal and hydrothermal resources are rich, and the produced medicine is hot and aromatic. Aromatic south herbs are numerous in quantity and excellent in quality and are mostly genuine medicinal materials. In the first 8 Lingnan Chinese medicinal materials protected in Lingnan Chinese medicinal material protection regulation of Guangdong province, 6 medicinal materials are aromatic south Chinese medicinal materials, which are exocarpium Citri Grandis, pericarpium Citri Reticulatae Chachiensis, fructus Amomi, herba Agastaches, lignum Aquilariae Resinatum, and fructus Citri Sarcodactylis. In addition, famous local south herbs such as cinnamon, sandalwood, dalbergia wood, galangal, star anise, fructus alpiniae oxyphyllae, rhizoma kaempferiae, round cardamom, katsumadai seed, tsaoko cardamon, turmeric, sappan wood and the like are aromatic south herbs. The aromatic south Chinese herbs have the advantages of numerous aromatic south herbs, definite drug effect, wide application and higher economic value.
Disclosure of Invention
The invention aims to provide an aromatic south medicine compound essential oil.
The second aspect of the invention aims to provide a preparation method of the aromatic south Chinese herbal medicine compound essential oil of the first aspect of the invention.
The third aspect of the invention aims to provide the application of the aromatic south Chinese herbal medicine compound essential oil of the first aspect of the invention in preparing products.
The fourth aspect of the invention aims to provide a product.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides aromatic south medicine compound essential oil with south medicine characteristics based on the theory of aromatic filth avoidance and the concept of traditional Chinese medicine preventive treatment, and the theory of modern medical mucosal immunity is combined, and aromatic south medicines such as cinnamon, clove, sandalwood, fingered citron and the like are preferably selected.
The invention provides a compound essential oil of aromatic south medicine, which comprises the following components: clove essential oil, cinnamon essential oil, wrinkled gianthyssop essential oil, sandalwood essential oil and fingered citron essential oil.
Preferably, the aromatic south medicine compound essential oil comprises the following components in parts by volume: 2-6 parts of clove essential oil, 10-18 parts of cinnamon essential oil, 15-25 parts of wrinkled gianthyssop essential oil, 25-35 parts of sandalwood essential oil and 10-20 parts of fingered citron essential oil.
Further preferably, the aromatic south medicine compound essential oil comprises the following components in parts by volume: 2-4 parts of clove essential oil, 10-18 parts of cinnamon essential oil, 15-22 parts of wrinkled gianthyssop essential oil, 28-35 parts of sandalwood essential oil and 14-20 parts of fingered citron essential oil.
Still further preferably, the aromatic south medicine compound essential oil comprises the following components in parts by volume: 2.5-4 parts of clove essential oil, 10-16 parts of cinnamon essential oil, 18-22 parts of wrinkled gianthyssop essential oil, 28-32 parts of sandalwood essential oil and 14-16 parts of fingered citron essential oil.
Preferably, the aromatic south medicine compound essential oil also comprises 300-500 parts of base oil.
Preferably, the base oil is at least one of jojoba oil, evening primrose seed oil, sweet almond oil, avocado oil, wheat germ oil, macadamia nut oil and grape seed oil.
Preferably, the preparation method of the clove essential oil comprises the following steps: clove is taken as a raw material, water is taken as a solvent, and the clove essential oil is obtained by extraction.
Further preferably, the weight ratio of the clove to the water is 1 (9-15).
Further preferably, the clove is crushed into coarse powder before being mixed with water.
Further preferably, the extraction condition is atmospheric steam distillation for 4-5 h.
Further preferably, the preparation method of the clove essential oil further comprises a purification step.
Preferably, the purification method comprises mixing the essential oil with sodium sulfate, and separating to obtain purified essential oil of clove.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the preparation method of the cinnamon essential oil comprises the following steps: cinnamon is taken as a raw material, water is taken as a solvent, and the cinnamon essential oil is obtained by extraction.
Further preferably, the weight ratio of the cinnamon to the water is 1 (9-15).
Further preferably, the cinnamon is crushed into coarse powder before being mixed with water.
Further preferably, the extraction condition is atmospheric steam distillation for 4-5 h.
Further preferably, the preparation method of the cinnamon essential oil further comprises a purification step.
Preferably, the purification method comprises mixing the essential oil with sodium sulfate, and separating to obtain purified cinnamon essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the raw material of the agastache essential oil is fresh agastache rugosa.
Preferably, the preparation method of the agastache essential oil comprises the following steps: fresh agastache rugosus is used as a raw material, and water is used as a solvent, and the agastache rugosus essential oil is obtained by extraction.
Further preferably, the Agastache rugosa is Pogostemon cablin.
Further preferably, the weight ratio of the ageratum to the water is 1 (20-25).
Further preferably, the agastache rugosa is cut into small pieces of 1cm to 2cm before being mixed with water.
Further preferably, the extraction condition is atmospheric steam distillation for 4-5 h.
Further preferably, the preparation method of the agastache essential oil further comprises a purification step.
Preferably, the purification method comprises mixing the essential oil with sodium sulfate, and separating to obtain purified essential oil of herba Agastaches.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the raw material of the fingered citron essential oil is fresh fingered citron.
Preferably, the preparation method of the fingered citron essential oil comprises the following steps: fresh fingered citron is taken as a raw material, water is taken as a solvent, and the fingered citron essential oil is obtained by extraction.
Further preferably, the fingered citron is bergamot.
Further preferably, the weight ratio of the fingered citron to the water is 1 (20-25).
Further preferably, the fingered citron is cut into small pieces of 1 cm-2 cm before being mixed with water.
Further preferably, the extraction condition is atmospheric steam distillation for 4-5 h.
Further preferably, the preparation method of the fingered citron essential oil also comprises a purification step.
Preferably, the purification method comprises mixing the essential oil with sodium sulfate, and separating to obtain the purified essential oil of fingered citron.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
The essential oil of the patchouli and the fingered citron must adopt fresh medicinal materials but cannot adopt dry medicinal materials, the essential oil extracted from the fresh medicinal materials has larger difference in odor, and the essential oil obtained from the fresh medicinal materials has more fresh and fragrant odor
Preferably, the preparation method of the sandalwood essential oil comprises the following steps: sandalwood is used as a raw material, water is used as a solvent, and the sandalwood essential oil is obtained by soaking and extracting.
Further preferably, the soaking time is not less than 72 hours; more preferably, the soaking time is 72-96 h.
In the preparation process of the sandalwood essential oil, soaking is a key step, the soaking process may be a process of naturally fermenting the sandalwood medicinal material under the action of microorganisms, and certain chemical components contained in the sandalwood essential oil may be decomposed or converted into other components by the microorganisms. Through natural fermentation, the smell of the obtained sandalwood essential oil is obviously changed and is more pleasant and comfortable, if the sandalwood essential oil is not soaked for enough time, the sandalwood essential oil is directly distilled by water vapor, the obtained sandalwood essential oil and the essential oil obtained by soaking for enough time have obvious difference in smell, so that the finally obtained compound essential oil has unsatisfactory and pleasant smell.
Further preferably, the weight ratio of the sandalwood to the water is 1 (9-15).
Further preferably, the sandalwood is crushed into coarse powder before being mixed with water.
Further preferably, the extraction condition is atmospheric steam distillation for 4-5 h.
Further preferably, the preparation method of the sandalwood essential oil further comprises a purification step.
Preferably, the purification method comprises mixing the essential oil with sodium sulfate, and separating to obtain purified sandalwood essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
In a second aspect of the present invention, there is provided a method for preparing the compound essential oil of aromatic south medicine of the first aspect of the present invention, comprising the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, aging, and mixing with base oil to obtain aromatic south medicine compound essential oil.
Preferably, the aging time is not less than 30 days;
further preferably, the aging time is 30-40 days.
All the plant essential oils are mixed and then are placed in a shady and cool place for aging for no less than 30 days, after 30 days, pleasant smell can be presented, and if the plant essential oils are not aged, the smell of the essential oils is not round and comfortable. During the aging process, esterification reaction, saponification reaction, condensation reaction, polymerization reaction, cracking reaction, disproportionation reaction, catalytic chain reaction, cyclization reaction, ring opening reaction and the like may occur between acid compounds and alcohol compounds, between esters, between aldehydes and aldehydes, between aldehyde and amine of various essential oils, so that new substances are generated, and molecules gradually reach equilibrium with the passage of time and are fused to generate unique smell.
Preferably, the aging is to seal the mixed essential oil and then age the essential oil in a shade.
Preferably, the aged essential oil is added into the base oil, and the mixture is stirred for 5-10 min in the same direction.
Preferably, the preparation method of the aromatic south medicine compound essential oil further comprises filtering.
Preferably, the filtration is performed by adopting a filter with a pore size of 5-10 μm.
In a third aspect of the invention, the application of the aromatic south medicine compound essential oil of the first aspect of the invention in preparing products is provided.
Preferably, the product is a product with bacteriostatic effect, a product with sleep-aiding effect and/or a product with odor-removing effect.
Preferably, the product can be a bacteriostatic gel, toothpaste, chewing gum, air freshener, or the like.
In a fourth aspect, the invention provides a product comprising the aromatic south Chinese herbal compound essential oil of the first aspect of the invention.
Preferably, the product is a product with bacteriostatic effect, a product with sleep-aiding effect and/or a product with odor-removing effect.
The invention has the beneficial effects that:
the aromatic south medicine composite essential oil provided by the invention does not contain essence, preservative and mineral oil, is pure, mild, safe and non-irritating, has round and mild smell, is comfortable, has costustoot flavor and fresh fruit flavor, has slight medicinal fragrance, and can be absorbed through mucous membranes such as nasal cavities, oral cavities and the like.
Through a plurality of tests, the clove essential oil, the cinnamon essential oil, the agastache essential oil, the sandalwood essential oil and the fingered citron essential oil in the aromatic south medicine compound essential oil are indispensable components, and the content must be within the content range, so that the prepared aromatic south medicine compound essential oil can just cover the pungent taste of the medicine essential oil, and the comfort, the safety and the effectiveness of human use are improved. Compared with the single essential oil in the formula, the aromatic south medicine compound essential oil has the advantages that the comfort level of the smell is remarkably improved, the strong traditional Chinese medicine smell of the single essential oil is avoided, and the problems that the single essential oil of the aromatic south medicines such as cinnamon, wrinkled gianthyssop herb and the like has single effect and strong medicine smell and is not easy to accept are effectively solved.
The aromatic south medicine compound essential oil provided by the invention has a strong bacteriostatic action, and has obvious inhibitory action on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans, wherein the inhibitory action on candida albicans is strongest. The aromatic south medicine compound essential oil shows good stability to ultraviolet rays and different temperatures. Meanwhile, the aromatic south medicine compound essential oil has good sleep aiding effect and peculiar smell removing effect, and experiments show that the aromatic south medicine compound essential oil can remarkably shorten the sleep latency period of mice induced by pentobarbital sodium and prolong the sleep duration of the mice.
The invention aims at the development and utilization of aromatic south medicine, is the fine and deep processing and utilization of the aromatic south medicine, and is beneficial to improving the technological content and the development level of aromatic south medicine products and developing the characteristics and the advantages of Ling south authentic medicinal materials.
The preparation method of the compound essential oil is simple and convenient, and can be used for large-scale production.
Detailed Description
The present invention will now be described in detail with reference to specific examples, but the scope of the present invention is not limited thereto.
The materials, reagents and the like used in the present examples are commercially available materials and reagents unless otherwise specified.
Example 1
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil (purchased from Chongqing spring Ziyu trade company, production lot 1035510162020);
the preparation method of the clove essential oil comprises the following steps: accurately weighing a certain amount of dry clove medicinal material, crushing into coarse powder, putting into a distillation kettle, adding distilled water which is 10 times of the weight of the dry clove medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving the essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain crude clove extraction essential oil, adding anhydrous sodium sulfate which accounts for 10% of the mass of the crude clove extraction essential oil, carrying out dehydration refining, and filtering to obtain the clove essential oil;
the preparation method of the cinnamon essential oil comprises the following steps: accurately weighing a certain amount of dried cinnamon medicinal material, crushing into coarse powder, putting into a distillation still, adding distilled water which is 10 times of the weight of the dried cinnamon medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving the essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain crude cinnamon extract oil, adding anhydrous sodium sulfate which accounts for 10% of the mass of the crude extract oil, carrying out dehydration refining, and filtering to obtain the cinnamon extract oil;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of fresh pogostemon cablin medicinal material, cutting into small sections of about 1cm, putting into a distillation kettle, adding distilled water of which the weight is 20 times that of the fresh pogostemon cablin medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain pogostemon cablin crude extract oil, adding anhydrous sodium sulfate of which the mass is 10% of the crude extract oil, carrying out dehydration and refining, and filtering to obtain pogostemon cablin essential oil;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood medicinal materials, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dry sandalwood medicinal materials, soaking for 72 hours at room temperature, then putting the medicinal powder and soaking liquid into a distillation kettle for atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10 percent of the mass of the crude extract oil for dehydration and refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of fresh bergamot fruits, cutting into small pieces of about 1cm, putting into a distillation kettle, adding distilled water of which the weight is 20 times that of the fresh bergamot fruits, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain bergamot crude extract oil, adding anhydrous sodium sulfate of which the mass is 10% of that of the crude extract oil for dehydration and refining, and filtering to obtain bergamot essential oil;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 2
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 2.5 parts of clove essential oil, 14 parts of cinnamon essential oil, 18 parts of patchouli essential oil, 28 parts of sandalwood essential oil, 14 parts of bergamot essential oil and 300 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 3
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3.5 parts of clove essential oil, 16 parts of cinnamon essential oil, 22 parts of patchouli essential oil, 32 parts of sandalwood essential oil, 16 parts of fingered citron essential oil and 500 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 4
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of fingered citron essential oil and 400 parts of jojoba oil.
Preparing clove essential oil: the preparation method is the same as that of example 1;
preparing cinnamon essential oil: the preparation method is the same as that of example 1;
preparing patchouli essential oil: the preparation method is the same as that of example 1;
preparing sandalwood essential oil: accurately weighing a certain amount of dry sandalwood medicinal materials, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dry sandalwood medicinal materials, soaking for 96 hours at room temperature, then putting the medicinal powder and soaking liquid into a distillation kettle for atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving the essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10 percent of the mass of the crude extract oil for dehydration and refining, and filtering to obtain the sandalwood essential oil;
preparing the bergamot essential oil: the preparation method is the same as that of example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 5
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 40 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 6
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of dry pogostemon cablin medicinal material, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight being 20 times that of the dry pogostemon cablin medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain pogostemon cablin crude extract essential oil, adding anhydrous sodium sulfate with the mass being 10% of that of the crude extract essential oil for dehydration and refining, and filtering to obtain pogostemon cablin essential oil;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 7
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of fingered citron essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of dried fructus citri sarcodactylis fruits, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight being 20 times that of the fresh fructus citri sarcodactylis fruits, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain crude fructus citri sarcodactylis essential oil, adding anhydrous sodium sulfate accounting for 10% of the mass of the crude essential oil for dehydration and refining, and filtering to obtain the essential oil of fructus citri sarcodactylis;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Pogostemonis essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 8
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood medicinal materials, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dry sandalwood medicinal materials, putting into a distillation still for atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving the essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10% of the mass of the crude extract oil for dehydration and refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 9
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood medicinal materials, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dry sandalwood medicinal materials, soaking for 24 hours at room temperature, then putting the medicinal powder and soaking liquid into a distillation kettle for atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10 percent of the mass of the crude extract oil for dehydration and refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 10
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood medicinal materials, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dry sandalwood medicinal materials, soaking for 48 hours at room temperature, then putting the medicinal powder and soaking liquid into a distillation kettle for atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving the essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10 percent of the mass of the crude extract oil for dehydration and refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, sealing, placing in shade, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic compound essential oil.
Example 11
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil uniformly, adding into jojoba oil, stirring in the same direction for 5min, mixing well, diluting and fusing sufficiently, filtering with a filter with pore diameter of 5 μm, packaging, and sealing to obtain aromatic south Chinese medicinal compound essential oil.
Example 12
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil uniformly, sealing and placing in shade, aging for 10 days, adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing well, diluting and fusing well, filtering with a filter with pore diameter of 5 μm, packaging, and sealing to obtain the aromatic south medicine compound essential oil.
Example 13
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of clove essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: the same as example 1;
the preparation method of the cinnamon essential oil comprises the following steps: the same as example 1;
the preparation method of the patchouli essential oil comprises the following steps: the same as example 1;
the preparation method of the sandalwood essential oil comprises the following steps: the same as example 1;
the preparation method of the bergamot essential oil comprises the following steps: the same as example 1;
the preparation method of the aromatic south Chinese medicine compound essential oil comprises the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil uniformly, sealing and placing in shade, aging for 20 days, adding the aged essential oil into jojoba oil, stirring in the same direction for 5min, mixing well, diluting and fusing well, filtering with a filter with pore diameter of 5 μm, packaging, and sealing to obtain the aromatic south medicine compound essential oil.
Comparative example 1
The aromatic south medicine essential oil comprises the following components in parts by volume: 3 parts of clove essential oil and 400 parts of jojoba oil;
the preparation method of the clove essential oil comprises the following steps: accurately weighing a certain amount of dry clove medicinal material, crushing into coarse powder, putting into a distillation kettle, adding distilled water which is 10 times of the weight of the dry clove medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving the essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain crude clove extraction essential oil, adding anhydrous sodium sulfate which accounts for 10% of the mass of the crude clove extraction essential oil, carrying out dehydration refining, filtering to obtain clove essential oil, sealing and placing in a shade, and aging for 30 days;
the preparation method of the aromatic south Chinese medicine essential oil comprises the following steps: adding flos Caryophylli essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic south Chinese medicinal essential oil.
Comparative example 2
The aromatic south medicine essential oil comprises the following components in parts by volume: 15 parts of cinnamon essential oil and 400 parts of jojoba oil;
the preparation method of the cinnamon essential oil comprises the following steps: accurately weighing a certain amount of dried cinnamon medicinal material, crushing into coarse powder, putting into a distillation still, adding distilled water which is 10 times of the weight of the dried cinnamon medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving the essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain crude cinnamon extract oil, adding anhydrous sodium sulfate which accounts for 10% of the mass of the crude cinnamon extract oil, carrying out dehydration refining, filtering to obtain cinnamon extract oil, sealing and placing in a shade, and aging for 30 days;
the preparation method of the aromatic south Chinese medicine essential oil comprises the following steps: adding cortex Cinnamomi essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic south drug essential oil.
Comparative example 3
The aromatic south medicine essential oil comprises the following components in parts by volume: 20 parts of patchouli essential oil and 400 parts of jojoba oil;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of fresh pogostemon cablin medicinal material, cutting into small sections of about 1cm, putting into a distillation kettle, adding distilled water of which the weight is 20 times that of the fresh pogostemon cablin medicinal material, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain pogostemon cablin crude extract oil, adding anhydrous sodium sulfate of which the mass is 10% of the crude extract oil for dehydration and refining, filtering to obtain pogostemon cablin essential oil, sealing and placing in a shade place, and aging for 30 days;
the preparation method of the aromatic south Chinese medicine essential oil comprises the following steps: adding patchouli essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic south drug essential oil.
Comparative example 4
The aromatic south medicine essential oil comprises the following components in parts by volume: 15 parts of fructus citri sarcodactylis essential oil and 400 parts of jojoba oil;
the preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of fresh bergamot fruits, cutting into small pieces of about 1cm, putting into a distillation kettle, adding distilled water of which the weight is 20 times that of the fresh bergamot fruits, carrying out atmospheric steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by using an essential oil extractor, carrying out distillation, condensation and oil-water separation to obtain bergamot crude extract oil, adding anhydrous sodium sulfate of which the mass is 10% of that of the crude extract oil for dehydration and refining, filtering to obtain bergamot essential oil, sealing and placing in a shade place, and aging for 30 days;
the preparation method of the aromatic south Chinese medicine essential oil comprises the following steps: adding fructus Citri Sarcodactylis essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic south Chinese medicinal essential oil.
Comparative example 5
The aromatic south medicine essential oil comprises the following components in parts by volume: 30 parts of sandalwood essential oil and 400 parts of jojoba oil;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dried sandalwood medicinal material, crushing into coarse powder, adding distilled water which is 10 times of the weight of the dried sandalwood medicinal material, soaking for 72 hours at room temperature, then putting the medicinal powder and soaking liquid into a distillation still for atmospheric steam distillation, wherein the distillation extraction time is 4 hours, receiving the essential oil by using an essential oil extractor, obtaining sandalwood crude extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate which accounts for 10 percent of the mass of the crude extract oil for dehydration and refining, filtering to obtain the sandalwood essential oil, sealing and placing in a shade place, and aging for 30 days;
the preparation method of the aromatic south Chinese medicine essential oil comprises the following steps: adding lignum Santali albi essential oil into jojoba oil, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm filter, packaging, and sealing to obtain aromatic south Chinese medicinal essential oil.
Effects of the embodiment
1. Sensory evaluation
50 volunteers of 18-60 years old were randomly selected as test population, and sensory evaluation (including appearance, smell, etc.) was performed on the aromatic south medicine compound essential oil prepared in examples 1-13 and comparative examples 1-5. Appearance index: appearance of the essential oil liquid: clear, pale yellow transparent liquid, no turbidity, no delamination. Odor index: the smell of the essential oil is smelled to make people feel pleasant, like, happy and comfortable. The test method comprises the following steps: the aromatic south medicine compound essential oil is smeared in the palm and smells the fragrance, everyone scores the smell according to the joyful and comfortable mood of the people, the maximum is 10 points, the minimum is 0 point, and finally, the average is taken.
The test results are shown in table 1, all the prepared aromatic south medicine compound essential oils are clear, light yellow, light brown or nearly colorless liquids, are not turbid and are not layered, but have certain differences in smell, the aromatic south medicine compound essential oils prepared in examples 1 to 5 have round and comfortable smell, have woody smell and fresh fruit smell, and have slight medicinal smell, while the aromatic south medicine compound essential oils prepared in comparative examples 1 to 5 have different defects in smell, such as pungency, nasal flushing, fishy smell, insufficient round and mild smell and the like. The pleasure degree of the smell indicates the acceptance of people to the smell of essential oil with different combinations, the value of the pleasure degree of the smell is the highest in the examples 1-5, and when the fresh patchouli, fingered citron and sandalwood essential oil are not adopted in the preparation process of the patchouli essential oil and the fingered citron essential oil, the sandalwood medicinal material is not soaked for more than 72 hours in the preparation process of the patchouli essential oil and the fingered citron essential oil, and the ageing time of the essential oil is not more than 30 days, the value of the pleasure degree of the smell of the prepared south aromatic medicine compound essential oil is lower, so that the smell acceptance degree of each example is higher than that of the comparative example, and the compatibility relationship between the smell characteristics and various essential oils and the preparation process have an obvious relationship.
TABLE 1 sensory evaluation of aromatic south drug Compound essential oil
Figure BDA0003584521490000151
Figure BDA0003584521490000161
2. Determination of bacteriostatic action
The effect of the aromatic south medicine compound essential oil of the embodiments 1 to 3 on bacteriostasis is measured by a filter paper sheet method, and experimental results show that the aromatic south medicine compound essential oil of the embodiments 1 to 3 has better inhibition effect on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans, the inhibition zone size of each aromatic south medicine compound essential oil on each bacterium is close, and no significant difference exists, wherein the diameter of the inhibition zone on the candida albicans is larger than 20mm, the inhibition effect is most obvious, and the inhibition effect is strong; the diameters of inhibition zones for escherichia coli, staphylococcus aureus and staphylococcus albus are all 10-20 mm, and the bacteria inhibition zone is moderate bacteria inhibition.
TABLE 2 results of antibacterial assay of aromatic south medicine compound essential oil of examples 1 to 3
Figure BDA0003584521490000162
3. Thermal and UV stability testing
In order to examine the stability of the aromatic south medicinal compound essential oil of examples 1 to 3, the thermal stability and the ultraviolet stability of the aromatic south medicinal compound essential oil were tested.
Thermal stability experiments: the compound essential oil of south aromatic medicine in the embodiment 1-3 is placed at different temperatures (20 ℃, 30 ℃, 40 ℃, 50 ℃ and 60 ℃) for 25min, the properties and the smell of the essential oil are observed, and the bacteriostatic effect of the compound essential oil of south aromatic medicine at different temperatures on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans is measured by a filter paper method.
Ultraviolet stability test: the aromatic south medicine compound essential oil of the embodiment 1-3 is irradiated by ultraviolet for different time (5min, 10min, 15min, 20min and 25min), the properties and the smell of the aromatic south medicine compound essential oil are observed, and the bacteriostatic effect of the aromatic south medicine compound essential oil subjected to ultraviolet irradiation treatment for different time on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans is measured by a filter paper method.
By observing the properties and the odor of the compound essential oil of south aromatic medicine in the embodiment 1-3 after being treated at different temperatures, the properties and the odor of the compound essential oil of south aromatic medicine are found to have no obvious difference with those before being treated. The antibacterial effect of the aromatic south medicine compound essential oil is further detected, and the result shows that the aromatic south medicine compound essential oil treated at different temperatures has no obvious difference with the aromatic south medicine compound essential oil treated before treatment (table 3), and shows that the temperature has no obvious influence on the antibacterial effect of the aromatic south medicine compound essential oil in the embodiments 1-3, namely, the antibacterial component of the aromatic south medicine compound essential oil is not obviously influenced along with the temperature rise, and the aromatic south medicine compound essential oil in the embodiments 1-3 has better thermal stability.
By observing the properties and the odor of the aromatic south medicine compound essential oil obtained in the embodiment 1-3 after being subjected to ultraviolet irradiation treatment for different time, the properties and the odor of the aromatic south medicine compound essential oil are not obviously different from those of the aromatic south medicine compound essential oil before being treated. The antibacterial effect of the aromatic south medicine compound essential oil is further detected, and the result shows that the aromatic south medicine compound essential oil after being subjected to ultraviolet irradiation treatment for different time has no obvious difference with the aromatic south medicine compound essential oil before being treated (table 4), so that the antibacterial effect of the aromatic south medicine compound essential oil in the embodiments 1-3 is not obviously influenced by ultraviolet light, and the aromatic south medicine compound essential oil in the embodiments 1-3 has good ultraviolet stability.
TABLE 3 antibacterial test results of aromatic south medicine compound essential oil treated at different temperatures
Figure BDA0003584521490000171
Figure BDA0003584521490000181
Table 4 bacteriostatic test results of aromatic south medicine compound essential oil treated by ultraviolet irradiation at different times
Figure BDA0003584521490000182
4. Sleep-aiding effect
The aromatic south medicine compound essential oil of examples 1 to 3 was applied to an ICR mouse induced by pentobarbital sodium, the sleep latency and the sleep duration of the mouse were recorded, and the sleep-aiding effect of the aromatic south medicine compound essential oil of examples 1 to 3 was examined by observing whether the aromatic south medicine compound essential oil of examples 1 to 3 can prolong the sleep time of the pentobarbital sodium.
The 4-week-old male ICR mice were selected and randomly divided into 9 groups, each of which was 13, specifically, a blank control group, a one-day group of aromatic south pharmaceutical compound essential oil (further subdivided into three groups, i.e., the one-day group of aromatic south pharmaceutical compound essential oil of example 1, the one-day group of aromatic south pharmaceutical compound essential oil of example 2, and the one-day group of aromatic south pharmaceutical compound essential oil of example 3), a three-day group of aromatic south pharmaceutical compound essential oil (further subdivided into the three-day group of aromatic south pharmaceutical compound essential oil of example 1, the three-day group of aromatic south pharmaceutical compound essential oil of example 2, and the three-day group of aromatic south pharmaceutical compound essential oil of example 3), a one-day group of positive control, and a three-day group of positive control.
Before the experiment, normal saline is injected into the abdominal cavity of mice of an empty control group and aromatic south medicine compound essential oil groups according to the proportion of 10mL/kg respectively. Adding aromatic south medicine compound essential oil with the concentration of 20g/L into an aromatherapy atomizer, placing the ultrasonic atomizer in an animal aromatherapy chamber, opening the ultrasonic atomizer for 5min to enable the aromatic south medicine compound essential oil to fill the whole aromatherapy chamber, placing mice of each group of the aromatic south medicine compound essential oil into the aromatherapy chamber, closing a box cover after the mice completely enter the aromatherapy chamber, enabling the mice to move in the aromatherapy chamber for 60min, and sequentially placing the mice back into a mouse cage after the completion of the inhalation. Wherein, the mice of the three-day group of the aromatic south medicine compound essential oil are continuously treated for 3 days according to the method. Mice in each group of positive control were administered (diazepam) by intraperitoneal injection at a dose of 3mg/kg (the dose was determined to be an effective dose in preliminary experiments to allow 100% of mice to sleep but not to allow too long sleep time) according to the weight of each mouse, and the diazepam was prepared in distilled water as a 0.05% solution. Mice in the positive control three-day group were treated continuously for 3 days as described above.
Pentobarbital sodium is injected into each group of mice after the last treatment in an intraperitoneal injection mode, the administration dose is 45mg/kg (the administration dose is the effective administration dose measured by a preliminary experiment, the mice can fall asleep 100 percent, but the sleeping time is not too long), and the pentobarbital sodium is prepared into a 0.5 percent solution by using normal saline. And (5) observing whether the treatment of each group can prolong the sleep time of the sodium pentobarbital, and recording the sleep latency and the sleep time of the mice of each group. The judgment basis is as follows: the falling asleep state is achieved without occurrence of turning reflection within 1 min; the time period from the intraperitoneal injection of the pentobarbital sodium to the disappearance of the righting reflex is the sleep latency period, and the time from the disappearance of the righting reflex to the restoration of the reflex is the sleep time.
The experimental results of the sleep latency and the sleep time induced by pentobarbital after the ICR mice inhale the compound essential oil are shown in Table 5, and compared with the blank control group mice, the sleep latency of the positive control one-day group mice and the sleep latency of the positive control three-day group mice are obviously different (P is less than 0.05) from the aspect of the sleep latency, so that the sleep latency of the mice can be obviously shortened; the sleep latency of each group of mice in one day group of the compound essential oil of aromatic south medicine has no significant difference (P is more than 0.05) with the sleep latency of mice in a blank control group, but the data still show that the compound essential oil of aromatic south medicine in examples 1-3 can shorten the sleep latency to a certain extent; compared with mice in a blank control group, the sleep latency of the mice in each group of three days of the compound essential oil of the aromatic south medicine is obviously shortened (P is less than 0.05), which shows that the sleep latency of the mice tends to be reduced along with the prolonging of the administration time and the increasing of the administration times of the mice in the embodiments 1 to 3, and meanwhile, the compound essential oil of the aromatic south medicine in the embodiments 1 to 3 has no obvious difference in the shortening of the sleep latency.
From the aspect of sleep duration, compared with the blank control group mice, the sleep duration of the positive control one-day group and positive control three-day group mice is obviously increased (P < 0.05); the sleep duration time of the mice in the group of three days of the compound essential oil of the aromatic south medicine is obviously prolonged (P <0.05), and the sleep duration time of the mice in the group of three days of the compound essential oil of the aromatic south medicine is obviously longer than the sleep duration time of the mice in the group of one day of the compound essential oil of the aromatic south medicine, which shows that the compound essential oil of the aromatic south medicine in the embodiments 1 to 3 can obviously prolong the sleep duration time of the mice, has the same change trend with the mice in the diazepam group, and meanwhile, the compound essential oil of the aromatic south medicine in the embodiments 1 to 3 has no obvious difference in prolonging the sleep duration time of the mice.
Table 5 examples 1-3 effects of aromatic south drug compound essential oils on sleep in mice (X ± s, n ═ 13)
Figure BDA0003584521490000191
Figure BDA0003584521490000201
Note: other groups were compared to the blank control group,. P <0.05,. P < 0.01.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

Claims (10)

1. A compound essential oil comprises the following components: clove essential oil, cinnamon essential oil, wrinkled gianthyssop essential oil, sandalwood essential oil and fingered citron essential oil.
2. The compound essential oil according to claim 1, which comprises the following components in parts by volume: 2-6 parts of clove essential oil, 10-18 parts of cinnamon essential oil, 15-25 parts of wrinkled gianthyssop essential oil, 25-35 parts of sandalwood essential oil and 10-20 parts of fingered citron essential oil.
3. The compound essential oil of claim 2, wherein the raw material of the agastache essential oil is fresh agastache rugosa; the preparation method of the agastache essential oil is preferably to extract fresh agastache rugosus serving as a raw material and water serving as a solvent to obtain the agastache rugosus essential oil.
4. The compound essential oil according to claim 3, wherein the raw material of the fingered citron essential oil is fresh fingered citron; the preparation method of the fingered citron essential oil is preferably as follows: fresh fingered citron is taken as a raw material, water is taken as a solvent, and the fingered citron essential oil is obtained by extraction.
5. The compound essential oil according to any one of claims 1 to 4, wherein the preparation method of the sandalwood essential oil comprises the following steps: soaking and extracting sandalwood serving as a raw material and water serving as a solvent to obtain sandalwood essential oil; the soaking time is preferably not less than 72 h.
6. The compound essential oil according to any one of claims 1 to 4, further comprising a base oil, wherein the base oil is preferably at least one of jojoba oil, evening primrose seed oil, sweet almond oil, apricot kernel oil, avocado oil, wheat germ oil, macadamia nut oil and grape seed oil.
7. The method for preparing the compound essential oil of claim 6, comprising the following steps: mixing flos Caryophylli essential oil, cortex Cinnamomi essential oil, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, aging, and mixing with base oil to obtain compound essential oil.
8. The method of claim 7, wherein the aging time is not less than 30 days.
9. Use of the compound essential oil of any one of claims 1 to 6 in the preparation of a product.
10. A product comprising the compound essential oil of any one of claims 1 to 6.
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Citations (2)

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CN105682669A (en) * 2013-09-06 2016-06-15 马斯公司 Oral anti-parasitic composition
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US20170056464A1 (en) * 2015-08-28 2017-03-02 Winston C. V. Parris Composition for musculoskeletal pain

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