CN114848717B - Aromatic south medicine compound essential oil and preparation method thereof - Google Patents

Aromatic south medicine compound essential oil and preparation method thereof Download PDF

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CN114848717B
CN114848717B CN202210359717.XA CN202210359717A CN114848717B CN 114848717 B CN114848717 B CN 114848717B CN 202210359717 A CN202210359717 A CN 202210359717A CN 114848717 B CN114848717 B CN 114848717B
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essential oil
oil
aromatic
parts
preparation
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CN114848717A (en
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潘利明
吴继婷
李颖琪
黄伟业
林铟潼
陈瑞松
张涧
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Guangdong Pharmaceutical University
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Abstract

The invention belongs to the technical field of aromatic south medicine essential oil, discloses an aromatic south medicine compound essential oil and a preparation method thereof, and in particular discloses a compound essential oil, which comprises the following components: butyl essential oil, cinnamon essential oil, wrinkled giant hyssop essential oil, sandalwood essential oil and fingered citron essential oil. The aromatic south drug compound essential oil provided by the invention does not contain essence, preservative and mineral oil, is pure, mild, safe and non-irritating, has round and comfortable smell, has the smell of costustoot and fresh fruit, has slightly drug smell, and can be absorbed through mucous membranes such as nasal cavities, oral cavities and the like.

Description

Aromatic south medicine compound essential oil and preparation method thereof
Technical Field
The invention belongs to the technical field of aromatic south medicine essential oil, and in particular relates to aromatic south medicine compound essential oil and a preparation method thereof.
Background
The aromatic Chinese medicine is a kind of Chinese medicine which can emit intense aromatic smell from medicinal parts or can generate aromatic smell after being processed by burning, heating and the like, can be used for treating and preventing diseases, and is an important component of clinical science of Chinese medicine. Aromatic traditional Chinese medicines have strong aromatic odor because of the rich essential oil, which is also called volatile oil, and is a general term for oily liquid which has volatility, can be distilled along with water vapor and is not miscible with water.
The essential oil has unique effects such as relieving exterior syndrome, eliminating dampness, activating qi-flowing, inducing resuscitation, etc., and can be applied to local or whole body to prevent and treat diseases. The essential oil has mild effect and small side effect, and has the functions of preventing infectious diseases, inhibiting bacteria, resisting inflammation, preserving, preventing and treating depression, resisting oxidation, promoting cell metabolism, promoting cell regeneration and the like. The Chinese medicinal essential oil combines the pharmacological action of Chinese medicine with aromatherapy of Chinese medicine, and has wide application in medical treatment, health promotion, food, articles for daily use, etc. However, most of the essential oils have weak pharmacological effects, single effects, and may have a more irritating taste, causing discomfort, and often not achieving the ideal effect when used alone. The compatibility of multiple essential oils can enhance the efficacy and play a synergistic role, and can mask and reduce bad smell, even generate pharmacological actions and specific smell which are not available in single essential oil, thereby expanding the application range of the essential oil.
Among the herbs in this section, the aromatic herb is called aromatic herb. Aromatic nan herbs are a great treasury. The tropical zone and subtropical zone in the Ling nan area of China are hot and rainy throughout the year, geothermal and hydrothermal resources are rich, and the produced medicinal materials are hot and aromatic at high temperature. Aromatic south herbs are numerous in quantity and good in quality, and most of them are genuine herbs. Among the first 8 protected Ling nan Chinese medicinal materials in the protection regulations of Ling nan Chinese medicinal materials in Guangdong province, 6 medicinal materials are aromatic south medicinal materials, which are exocarpium Citri Grandis, pericarpium Citri Reticulatae Chachiensis, spring sand, herba Pogostemonis, lignum Aquilariae Resinatum and fructus Citri Sarcodactylis. In addition, the famous daodality nan herbs such as cinnamon, sandalwood, rosewood, galangal, star anise, alpinia oxyphylla, kaempferia galanga, cardamom, katsumadai seed, tsaoko cardamon, turmeric, sappan wood and the like are all aromatic south herbs. The amount of aromatic south herbs is numerous, the efficacy is definite, the application is wide, and the economic value is higher.
Disclosure of Invention
The invention aims at providing aromatic south medicine compound essential oil.
The second aspect of the present invention is to provide a method for preparing the aromatic south drug compound essential oil of the first aspect of the present invention.
The invention aims at providing the application of the aromatic south drug compound essential oil in the first aspect in the preparation of products.
The object of the fourth aspect of the invention is to provide a product.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
based on the theory of fragrance and dirt avoidance and the concept of treating the disease in traditional Chinese medicine, the invention combines the theory of modern medical mucosa immunization, preferably aromatic south medicine such as cinnamon, clove, sandalwood, fingered citron and the like, and provides the aromatic south medicine compound essential oil with the characteristic of south medicine.
The first aspect of the invention provides aromatic south drug compound essential oil, which comprises the following components: butyl essential oil, cinnamon essential oil, wrinkled giant hyssop essential oil, sandalwood essential oil and fingered citron essential oil.
Preferably, the aromatic south drug compound essential oil comprises the following components in parts by volume: 2-6 parts of clove essential oil, 10-18 parts of cinnamon essential oil, 15-25 parts of patchouli essential oil, 25-35 parts of sandalwood essential oil and 10-20 parts of fingered citron essential oil.
Further preferably, the aromatic south drug compound essential oil comprises the following components in parts by volume: 2-4 parts of clove essential oil, 10-18 parts of cinnamon essential oil, 15-22 parts of patchouli essential oil, 28-35 parts of sandalwood essential oil and 14-20 parts of fingered citron essential oil.
Still more preferably, the aromatic south drug compound essential oil comprises the following components in parts by volume: 2.5 to 4 parts of clove essential oil, 10 to 16 parts of cinnamon essential oil, 18 to 22 parts of patchouli essential oil, 28 to 32 parts of sandalwood essential oil and 14 to 16 parts of fingered citron essential oil.
Preferably, the aromatic south drug compound essential oil also comprises 300-500 parts of base oil.
Preferably, the base oil is at least one of jojoba oil, evening primrose seed oil, sweet almond oil, apricot kernel oil, avocado oil, wheat germ oil, macadamia nut oil and grape seed oil.
Preferably, the preparation method of the clove essential oil comprises the following steps: the clove essential oil is obtained by taking clove as a raw material and water as a solvent and extracting.
Further preferably, the weight ratio of the clove to the water is 1 (9-15).
Further preferably, the clove is crushed into coarse powder before mixing with water.
More preferably, the extraction condition is atmospheric steam distillation for 4 to 5 hours.
Further preferably, the preparation method of the clove essential oil further comprises a purification step.
Preferably, the purification method is to mix the essential oil with sodium sulfate and separate to obtain the purified clove essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the preparation method of the cinnamon essential oil comprises the following steps: the cinnamon essential oil is obtained by taking cinnamon as a raw material and water as a solvent and extracting.
Further preferably, the weight ratio of the cinnamon to the water is 1 (9-15).
Further preferably, the cinnamon is crushed into coarse powder before mixing with water.
More preferably, the extraction condition is atmospheric steam distillation for 4 to 5 hours.
Further preferably, the preparation method of the cinnamon essential oil further comprises a purification step.
Preferably, the purification method is to mix the essential oil with sodium sulfate and separate to obtain the purified cinnamon essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the raw material of the wrinkled giant hyssop essential oil is fresh wrinkled giant hyssop.
Preferably, the preparation method of the wrinkled giant hyssop essential oil comprises the following steps: fresh agastache is taken as a raw material, water is taken as a solvent, and the extract is obtained.
Further preferably, the agastache rugosus is pogostemon cablin.
Further preferably, the weight ratio of the agastache rugosa to the water is 1 (20-25).
Further preferably, the agastache rugosus is cut into small pieces of 1cm to 2cm before being mixed with water.
More preferably, the extraction condition is atmospheric steam distillation for 4 to 5 hours.
Further preferably, the preparation method of the wrinkled giant hyssop essential oil further comprises a purification step.
Preferably, the purification method is to mix the essential oil with sodium sulfate and separate to obtain the purified wrinkled giant hyssop essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
Preferably, the raw material of the fingered citron essential oil is fresh fingered citron.
Preferably, the preparation method of the fingered citron essential oil comprises the following steps: fresh fingered citron is taken as a raw material, water is taken as a solvent, and fingered citron essential oil is obtained by extraction.
Further preferably, the fingered citron is a wide fingered citron.
Further preferably, the weight ratio of the fingered citron to the water is 1 (20-25).
Further preferably, the fingered citron is cut into small pieces of 1cm to 2cm before being mixed with water.
More preferably, the extraction condition is atmospheric steam distillation for 4 to 5 hours.
Further preferably, the preparation method of the fingered citron essential oil further comprises a purification step.
Preferably, the purification method is to mix the essential oil with sodium sulfate and separate to obtain the purified fingered citron essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
The patchouli and the bergamot essential oil must adopt fresh medicinal materials, but cannot adopt dried medicinal materials, so that the smell of the essential oil extracted from the fresh medicinal materials and the smell of the essential oil extracted from the dried medicinal materials are greatly different, and the smell of the essential oil obtained from the fresh medicinal materials is more fresh and aromatic.
Preferably, the preparation method of the sandalwood essential oil comprises the following steps: taking sandalwood as a raw material, taking water as a solvent, and soaking and extracting to obtain the sandalwood essential oil.
Further preferably, the soaking time is not less than 72 hours; more preferably, the soaking time is 72-96 hours.
In the process of preparing the sandalwood essential oil, soaking is a key step, the soaking process may be a process of naturally fermenting the sandalwood medicinal material under the action of microorganisms, and certain chemical components contained in the sandalwood essential oil may be decomposed or converted into other components by the microorganisms. The odor of the obtained sandalwood essential oil is obviously changed through natural fermentation, the sandalwood essential oil is more pleasant and comfortable, if the sandalwood essential oil is not soaked for enough time, the fermentation time is insufficient, the sandalwood essential oil is directly distilled by water vapor, the obtained sandalwood essential oil is obviously different from the essential oil obtained after the sandalwood essential oil is soaked for enough time in odor, and the odor of the finally obtained compound essential oil is not round enough and pleasant.
Further preferably, the weight ratio of the sandalwood to the water is 1 (9-15).
Further preferably, the sandalwood is crushed into a coarse powder before mixing with water.
More preferably, the extraction condition is atmospheric steam distillation for 4 to 5 hours.
Further preferably, the preparation method of the sandalwood essential oil further comprises a purification step.
Preferably, the purification method is to mix the essential oil with sodium sulfate and separate to obtain the purified sandalwood essential oil.
Preferably, the addition amount of the sodium sulfate is 10-15% of the mass of the essential oil.
The second aspect of the present invention provides a method for preparing the aromatic south drug compound essential oil according to the first aspect of the present invention, comprising the following steps: mixing the butyl essential oil, the cinnamon essential oil, the wrinkled giant hyssop essential oil, the sandalwood essential oil and the fingered citron essential oil, aging, and mixing with the base oil to obtain the aromatic south medicine compound essential oil.
Preferably, the aging time is not less than 30 days;
further preferably, the aging time is 30 to 40 days.
All the plant essential oils are mixed and then are aged for at least 30 days in a shade, and after 30 days, pleasant smell can be presented, and if the plant essential oils are not aged, the smell of the essential oils is not round and comfortable enough. During aging, esterification, saponification, condensation, polymerization, cleavage, disproportionation, catalytic chain reaction, cyclization, ring opening reaction and the like may occur between the acid compounds and alcohol compounds, between esters, between aldehydes and aldehydes, between aldehydes and amines of various essential oils, so that new substances are generated, and as time goes by, the molecules gradually reach equilibrium, and the fusion generates unique odors.
Preferably, the aging is aging in a shade after sealing the mixed essential oil.
Preferably, the aged essential oil is added into the base oil and stirred in the same direction for 5-10 min.
Preferably, the preparation method of the aromatic south drug compound essential oil further comprises filtration.
Preferably, the filtration is carried out by using a filter having a pore size of 5 to 10. Mu.m.
In a third aspect, the present invention provides an application of the aromatic south drug compound essential oil of the first aspect in preparing a product.
Preferably, the product is a product with bacteriostatic effect, a product with sleep-aiding effect and/or a product with odor-removing effect.
Preferably, the product can be a daily product such as antibacterial gel, toothpaste, chewing gum, air freshener, and the like.
In a fourth aspect, the present invention provides a product comprising the aromatic south drug compound essential oil of the first aspect of the present invention.
Preferably, the product is a product with bacteriostatic effect, a product with sleep-aiding effect and/or a product with odor-removing effect.
The beneficial effects of the invention are as follows:
the aromatic south drug compound essential oil provided by the invention does not contain essence, preservative and mineral oil, is pure, mild, safe and non-irritating, has round and comfortable smell, has the smell of costustoot and fresh fruit, has slightly drug smell, and can be absorbed through mucous membranes such as nasal cavities, oral cavities and the like.
Through multiple tests, the aromatic south drug compound essential oil disclosed by the invention is an essential component of clove essential oil, cinnamon essential oil, wrinkled giant hyssop essential oil, sandalwood essential oil and fingered citron essential oil, and the prepared aromatic south drug compound essential oil can just mask the irritation taste of the drug essential oil, so that the comfort, safety and effectiveness of human body use are improved. Compared with single essential oil in the formula, the aromatic south medicine compound essential oil has obviously improved comfort level of smell, does not have strong traditional Chinese medicine smell of single essential oil, and effectively solves the problems that the single essential oil of aromatic south medicine such as cinnamon, wrinkled giant hyssop and the like has single action and strong medicine smell and is not easy to accept.
The aromatic south drug compound essential oil provided by the invention has a strong antibacterial effect, and has obvious inhibition effect on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans, wherein the inhibition effect on candida albicans is the strongest. And the aromatic south drug compound essential oil has good stability to ultraviolet rays and different temperature treatments. Meanwhile, the aromatic south medicine compound essential oil has good sleep-aiding effect and peculiar smell removing effect, and experiments show that the aromatic south medicine compound essential oil can obviously shorten the sleep latency of mice induced by sodium pentobarbital and prolong the sleep duration of the mice.
The invention aims at the development and utilization of the aromatic south medicine, is the deep processing and utilization of the aromatic south medicine, is favorable for improving the technological content and development level of the aromatic south medicine product, and promotes the characteristics and advantages of the medicinal materials in the south of the Ling.
The preparation method of the compound essential oil is simple and convenient, and can be used for large-scale production.
Detailed Description
The invention will now be described in detail with reference to specific examples, without limiting the scope of the invention.
The materials, reagents and the like used in this example are commercially available materials and reagents unless otherwise specified.
Example 1
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil (purchased from Chongqing spring Imperial trade, production lot number 1035510162020);
the preparation method of the butyl essential oil comprises the following steps: accurately weighing a certain amount of dry clove medicinal materials, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight 10 times of that of the dry clove medicinal materials, performing normal-pressure steam distillation, extracting for 4 hours, receiving essential oil by an essential oil extractor, distilling, condensing and separating oil from water to obtain crude clove extract oil, adding anhydrous sodium sulfate with the weight 10% of that of the crude clove extract oil, dehydrating and refining, and filtering to obtain butyl essential oil;
The preparation method of the cinnamon essential oil comprises the following steps: accurately weighing a certain amount of dry cinnamon medicinal materials, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight 10 times of that of the dry cinnamon medicinal materials, performing normal-pressure steam distillation, extracting for 4 hours, receiving essential oil by an essential oil extractor, obtaining crude cinnamon essential oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight 10% of that of the crude cinnamon essential oil, dehydrating and refining, and filtering to obtain cinnamon essential oil;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of fresh herba Agastaches, cutting into small sections of about 1cm, putting into a distillation kettle, adding distilled water with the weight of 20 times of that of the fresh herba Agastaches, performing normal pressure steam distillation, extracting for 4 hours, receiving essential oil by using an essential oil extractor, obtaining coarse herba Agastaches extract oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the coarse extract oil for dehydration refining, and filtering to obtain herba Agastaches extract oil;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, soaking at room temperature for 72h, then adding the medicinal powder and the soaking solution into a distillation kettle for normal pressure steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by an essential oil extractor, obtaining crude sandalwood extract by distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude extract for dehydration refining, and filtering to obtain the sandalwood essential oil;
The preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of fresh bergamot fruits, cutting into small blocks with the weight of about 1cm, putting into a distillation kettle, adding distilled water with the weight of 20 times of the fresh bergamot fruits, performing normal-pressure steam distillation, wherein the distillation and extraction time is 4 hours, receiving essential oil by an essential oil extractor, obtaining crude bergamot essential oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude bergamot essential oil for dehydration refining, and filtering to obtain the bergamot essential oil;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 2
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 2.5 parts of clove essential oil, 14 parts of cinnamon essential oil, 18 parts of patchouli essential oil, 28 parts of sandalwood essential oil, 14 parts of bergamot essential oil and 300 parts of jojoba oil;
The preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 3
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3.5 parts of clove essential oil, 16 parts of cinnamon essential oil, 22 parts of patchouli essential oil, 32 parts of sandalwood essential oil, 16 parts of bergamot essential oil and 500 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
The preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 4
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil.
Preparation of butyl essential oil: the preparation method is the same as in example 1;
preparation of cinnamon essential oil: the preparation method is the same as in example 1;
preparation of patchouli essential oil: the preparation method is the same as in example 1;
preparation of sandalwood essential oil: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, soaking at room temperature for 96 hours, then adding the medicinal powder and the soaking solution into a distillation kettle for normal pressure steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by an essential oil extractor, obtaining crude sandalwood extract by distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude extract for dehydration refining, and filtering to obtain the sandalwood essential oil;
Preparation of bergamot essential oil: the preparation method is the same as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 5
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 40 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 6
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of dry herba Agastaches, pulverizing into coarse powder, adding into a distillation kettle, adding distilled water with 20 times of dry herba Agastaches, performing normal pressure steam distillation for 4 hr, collecting essential oil with an essential oil extractor, distilling, condensing, separating oil from water to obtain coarse herba Agastaches extract, adding anhydrous sodium sulfate with 10% of coarse herba Agastaches extract oil quality, dehydrating, and filtering to obtain herba Agastaches extract;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 7
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of dried bergamot fruits, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight of 20 times of that of fresh bergamot fruits, performing normal-pressure steam distillation, extracting for 4 hours, receiving essential oil by an essential oil extractor, obtaining crude bergamot essential oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude bergamot essential oil for dehydration refining, and filtering to obtain the bergamot essential oil;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 8
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, adding into a distillation kettle, performing normal pressure steam distillation for 4 hours, receiving essential oil by an essential oil extractor, distilling, condensing, separating oil from water to obtain crude sandalwood extract, adding anhydrous sodium sulfate with the weight of 10% of the crude sandalwood extract, dehydrating and refining, and filtering to obtain sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 9
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, soaking at room temperature for 24 hours, then adding the medicinal powder and the soaking solution into a distillation kettle for normal pressure steam distillation, wherein the distillation extraction time is 4 hours, receiving essential oil by an essential oil extractor, obtaining crude sandalwood extract by distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude extract for dehydration refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 10
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, soaking at room temperature for 48h, then adding the medicinal powder and the soaking solution into a distillation kettle for normal pressure steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by an essential oil extractor, obtaining crude sandalwood extract by distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude extract for dehydration refining, and filtering to obtain the sandalwood essential oil;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: uniformly mixing the butyl essential oil, the cinnamon essential oil, the patchouli essential oil, the sandalwood essential oil and the bergamot essential oil, sealing and placing in a shade place, and aging for 30 days; adding the aged essential oil into jojoba oil, stirring for 5min in the same direction, fully mixing, fully diluting and fusing, filtering with a 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicine compound essential oil.
Example 11
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: mixing oleum Caryophylli, oleum Cinnamomi, herba Pogostemonis, oleum Santali albi and oleum Citri Sarcodactylis uniformly, adding into oleum Nelumbinis, stirring for 5min, mixing uniformly, diluting, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south drug compound essential oil.
Example 12
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
The preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
the preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: mixing oleum Caryophylli, oleum Cinnamomi, herba Pogostemonis essential oil, oleum Santali albi and oleum Citri Sarcodactylis, sealing, aging for 10 days, adding the aged essential oil into jojoba oil, stirring for 5min, mixing, diluting, filtering with 5 μm pore diameter filter, packaging, and sealing to obtain aromatic south medicinal compound essential oil.
Example 13
The aromatic south medicine compound essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil, 15 parts of cinnamon essential oil, 20 parts of patchouli essential oil, 30 parts of sandalwood essential oil, 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: as in example 1;
the preparation method of the cinnamon essential oil comprises the following steps: as in example 1;
the preparation method of the patchouli essential oil comprises the following steps: as in example 1;
the preparation method of the sandalwood essential oil comprises the following steps: as in example 1;
The preparation method of the bergamot essential oil comprises the following steps: as in example 1;
the preparation method of the aromatic south drug compound essential oil comprises the following steps: mixing oleum Caryophylli, oleum Cinnamomi, herba Pogostemonis essential oil, oleum Santali albi and oleum Citri Sarcodactylis, sealing, aging for 20 days, adding the aged essential oil into jojoba oil, stirring for 5min, mixing, diluting, filtering with 5 μm pore diameter filter, packaging, and sealing to obtain aromatic south medicinal compound essential oil.
Comparative example 1
The aromatic south medicine essential oil comprises the following components in parts by volume: 3 parts of butyl essential oil and 400 parts of jojoba oil;
the preparation method of the butyl essential oil comprises the following steps: accurately weighing a certain amount of dry flos Caryophylli medicinal materials, pulverizing into coarse powder, adding into a distillation kettle, adding distilled water 10 times the weight of the dry flos Caryophylli medicinal materials, performing normal pressure steam distillation for 4 hr, collecting essential oil with an essential oil extractor, distilling, condensing, separating oil from water to obtain flos Caryophylli crude extract, adding anhydrous sodium sulfate 10% of the crude extract oil for dehydration refining, filtering to obtain oleum Caryophylli, sealing, standing in shade place, and aging for 30 days;
The preparation method of the aromatic south medicinal essential oil comprises the following steps: adding oleum Caryophylli into oleum Nelumbinis, stirring for 5min, mixing, diluting, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicinal essential oil.
Comparative example 2
The aromatic south medicine essential oil comprises the following components in parts by volume: 15 parts of cinnamon essential oil and 400 parts of jojoba oil;
the preparation method of the cinnamon essential oil comprises the following steps: accurately weighing a certain amount of dry cinnamon medicinal materials, crushing into coarse powder, putting into a distillation kettle, adding distilled water with the weight of 10 times of that of the dry cinnamon medicinal materials, performing normal-pressure steam distillation, extracting for 4 hours, receiving essential oil by an essential oil extractor, obtaining crude cinnamon essential oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of that of the crude cinnamon essential oil for dehydration refining, filtering to obtain cinnamon essential oil, sealing and placing in a shady place, and aging for 30 days;
the preparation method of the aromatic south medicinal essential oil comprises the following steps: adding oleum Cinnamomi into jojoba oil, stirring for 5min, mixing, diluting, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicinal essential oil.
Comparative example 3
The aromatic south medicine essential oil comprises the following components in parts by volume: 20 parts of patchouli essential oil and 400 parts of jojoba oil;
the preparation method of the patchouli essential oil comprises the following steps: accurately weighing a certain amount of fresh herba Agastaches, cutting into small sections of about 1cm, putting into a distillation kettle, adding distilled water with the weight of 20 times of that of the fresh herba Agastaches, performing normal pressure steam distillation, extracting for 4 hours, receiving essential oil by using an essential oil extractor, obtaining coarse herba Agastaches extract after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the coarse extract for dehydration refining, filtering to obtain herba Agastaches extract, sealing and placing in a shady place, and aging for 30 days;
the preparation method of the aromatic south medicinal essential oil comprises the following steps: adding oleum herba Pogostemonis into oleum Simmondsia chinensis, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicinal essential oil.
Comparative example 4
The aromatic south medicine essential oil comprises the following components in parts by volume: 15 parts of bergamot essential oil and 400 parts of jojoba oil;
the preparation method of the bergamot essential oil comprises the following steps: accurately weighing a certain amount of fresh bergamot fruits, cutting into small blocks with the weight of about 1cm, putting the small blocks into a distillation kettle, adding distilled water with the weight of 20 times of the fresh bergamot fruits, performing normal-pressure steam distillation, wherein the distillation and extraction time is 4 hours, receiving essential oil by an essential oil extractor, obtaining crude bergamot essential oil after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the weight of 10% of the crude bergamot essential oil for dehydration refining, filtering to obtain the bergamot essential oil, sealing and placing in a shady place, and aging for 30 days;
The preparation method of the aromatic south medicinal essential oil comprises the following steps: adding oleum Citri Sarcodactylis into oleum Simmondsia chinensis, stirring in the same direction for 5min, mixing, diluting, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicinal essential oil.
Comparative example 5
The aromatic south medicine essential oil comprises the following components in parts by volume: 30 parts of sandalwood essential oil and 400 parts of jojoba oil;
the preparation method of the sandalwood essential oil comprises the following steps: accurately weighing a certain amount of dry sandalwood, pulverizing into coarse powder, adding distilled water 10 times the weight of the dry sandalwood, soaking at room temperature for 72h, then adding the medicinal powder and the soaking solution into a distillation kettle for normal pressure steam distillation, wherein the distillation extraction time is 4h, receiving essential oil by an essential oil extractor, obtaining crude sandalwood extract after distillation, condensation and oil-water separation, adding anhydrous sodium sulfate with the crude extract oil quality of 10% for dehydration refining, filtering to obtain sandalwood essential oil, sealing and placing in a shade place, and aging for 30 days;
the preparation method of the aromatic south medicinal essential oil comprises the following steps: adding oleum Santali albi into oleum Simmondsia chinensis, stirring in the same direction for 5min, mixing, diluting, mixing, filtering with 5 μm pore size filter, packaging, and sealing to obtain aromatic south medicinal essential oil.
Effect examples
1. Sensory evaluation
50 volunteers 18 to 60 years old are randomly selected as test groups, and sensory evaluation (including appearance, smell and the like) is carried out on the aromatic south drug compound essential oils prepared in examples 1 to 13 and comparative examples 1 to 5. Appearance indexes: the essential oil liquid appearance is presented: clear, pale yellow transparent liquid, no turbidity and no delamination. Odor index: the smell of the essential oil is pleasant, loved, happy and comfortable. The testing method comprises the following steps: the aromatic south medicine compound essential oil is smeared on the palm center to smell fragrance, each person scores the smell according to the happy mood and happy degree, the highest score is 10, the lowest score is 0, and finally the average score is taken.
The test results are shown in table 1, all the prepared aromatic south drug compound essential oils are clear, pale yellow, light brown or nearly colorless liquid, are not turbid and layered, but have certain difference in smell, the aromatic south drug compound essential oils prepared in examples 1-5 are round and pleasant in smell, have costustoot and fresh fruit smell, have slightly medicinal smell, and the aromatic south drug compound essential oils prepared in comparative examples 1-5 have defects of different degrees in smell, such as pungency, nose flushing, fishy smell, and insufficient round smell and the like. The pleasant degree of the smell indicates the acceptance of the smell of different combined essential oils by the crowd, and the score of the pleasant degree of the smell can be seen, the scores of examples 1-5 are highest, when fresh patchouli, the patchouli medicinal material and the sandalwood medicinal material are not adopted in the preparation process of the patchouli essential oil and the patchouli essential oil, the sandalwood medicinal material is not soaked for more than 72 hours in the preparation process of the patchouli essential oil and the sandalwood essential oil, and the score of the pleasant degree of the smell of the prepared aromatic south medicinal compound essential oil is lower when the aging time of the essential oil is not more than 30 days, so that the flavor acceptance of each example is higher than that of the comparative example, and the compatibility relation between the smell characteristics and various essential oils and the preparation process are obvious.
Table 1 sensory evaluation of aromatic nanyao compound essential oils
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2. Determination of bacteriostasis
The antibacterial effect of the aromatic south medicine compound essential oil of the examples 1-3 is measured by using a filter paper sheet method, and experimental results show that the aromatic south medicine compound essential oil of the examples 1-3 has better inhibition effect on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans, and the antibacterial circle sizes of all the aromatic south medicine compound essential oils on all bacteria are close without obvious difference, wherein the diameter of the antibacterial circle on candida albicans is larger than 20mm, and the inhibition effect is most obvious and is strong; the diameter of the inhibition zone for the escherichia coli, staphylococcus aureus and staphylococcus albus is 10-20 mm, and the bacteria are moderately inhibited.
Table 2 antibacterial assay results of aromatic nan drug compound essential oils of examples 1-3
3. Thermal and ultraviolet stability detection
In order to examine the stability of the aromatic south drug compound essential oil of examples 1 to 3, experiments were performed on the thermal stability and ultraviolet stability of the aromatic south drug compound essential oil.
Thermal stability experiments: the aromatic south drug compound essential oil of examples 1 to 3 was placed under different temperatures (20 ℃, 30 ℃, 40 ℃, 50 and 60 ℃) for 25 minutes, the properties and the smell thereof were observed, and the antibacterial effect of the aromatic south drug compound essential oil on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans at different temperatures was measured by using a filter paper sheet method.
Ultraviolet stability experiment: the aromatic south drug compound essential oil of examples 1 to 3 was irradiated with ultraviolet rays for different times (5 min, 10min, 15min, 20min and 25 min), the properties and the smell thereof were observed, and the antibacterial effect of the aromatic south drug compound essential oil after the ultraviolet irradiation treatment for different times on escherichia coli, staphylococcus aureus, staphylococcus albus and candida albicans was measured by a filter paper sheet method.
By observing the properties and the smell of the aromatic south drug compound essential oil of examples 1-3 after being treated at different temperatures, no obvious difference between the properties and the smell of the aromatic south drug compound essential oil and the properties and the smell of the aromatic south drug compound essential oil before being treated is found. The antibacterial effect of each aromatic south drug compound essential oil is further detected, and the result shows that the aromatic south drug compound essential oil treated at different temperatures has no obvious difference from the aromatic south drug compound essential oil before being treated (table 3), and the temperature has no obvious influence on the antibacterial effect of the aromatic south drug compound essential oil in examples 1-3, namely, the antibacterial components of the aromatic south drug compound essential oil are not obviously influenced along with the temperature rise, and the aromatic south drug compound essential oil in examples 1-3 has better heat stability.
By observing the properties and the smell of the aromatic south drug compound essential oil in examples 1-3 after being subjected to ultraviolet irradiation for different times, no obvious difference between the properties and the smell of the aromatic south drug compound essential oil and the properties and the smell of the aromatic south drug compound essential oil before being treated is found. The antibacterial effect of each aromatic south drug compound essential oil is further detected, and the result shows that the aromatic south drug compound essential oil subjected to ultraviolet irradiation treatment for different time has no obvious difference from the aromatic south drug compound essential oil before the treatment (table 4), and the result shows that ultraviolet light has no obvious influence on the antibacterial effect of the aromatic south drug compound essential oil in examples 1-3, and the aromatic south drug compound essential oil in examples 1-3 has good ultraviolet stability.
TABLE 3 antibacterial assay results of aromatic south drug Compound essential oil treated at different temperatures
TABLE 4 antibacterial assay results of aromatic south drug Compound essential oils after different time ultraviolet irradiation treatment
4. Sleep-aiding effect
The aromatic south drug compound essential oil of examples 1 to 3 was applied to the pentobarbital sodium-induced ICR mice, the sleep latency and sleep duration of the mice were recorded, and the sleeping-aiding effect of the aromatic south drug compound essential oil of examples 1 to 3 was examined by observing whether the aromatic south drug compound essential oil of examples 1 to 3 can prolong the sleeping time of pentobarbital sodium.
Male ICR mice of 4 weeks of age are selected and randomly divided into 9 groups, 13 groups are specifically a blank control group, an aromatic south drug compound essential oil one day group (further divided into three groups, namely an aromatic south drug compound essential oil one day group of example 1, an aromatic south drug compound essential oil one day group of example 2, an aromatic south drug compound essential oil one day group of example 3), an aromatic south drug compound essential oil three day group (further divided into an aromatic south drug compound essential oil three day group of example 1, an aromatic south drug compound essential oil three day group of example 2, an aromatic south drug compound essential oil three day group of example 3), a positive control one day group and a positive control three day group.
Before the experiment, the physiological saline is respectively injected into the abdominal cavity of the mice in the blank control group and the aromatic south drug compound essential oil groups according to the ratio of 10 mL/kg. Adding 20g/L aromatic south drug compound essential oil into an aromatherapy atomizer, placing the ultrasonic atomizer into an animal aromatherapy chamber, opening the ultrasonic atomizer for 5min to fill the whole aromatherapy chamber with the aromatic south drug compound essential oil, placing the mice of each group of aromatic south drug compound essential oil into the aromatherapy chamber, closing a box cover after the mice completely enter the aromatherapy chamber, allowing the mice to move in the aromatherapy chamber for 60min, and sequentially placing the mice into a mouse cage after the inhalation is completed. Wherein, for each group of mice of the aromatic south drug compound essential oil three-day group, the treatment is carried out for 3 days continuously according to the method. The mice of each positive control group were given 3mg/kg (this dose was an effective dose measured by pre-experiments to enable 100% of the mice to fall asleep but not to sleep for too long) by intraperitoneal injection, and diazepam was formulated as a 0.05% solution with distilled water. Wherein the positive control three-day group of mice was treated as described above for 3 consecutive days.
The mice of the last treated group were injected with pentobarbital sodium by intraperitoneal injection at a dose of 45mg/kg (this dose was an effective dose measured by a preliminary experiment, which could make the mice fall asleep 100% but not make the sleep time too long), and the pentobarbital sodium was formulated into a 0.5% solution with physiological saline. The treatment of each group was observed for prolonged sleep time of sodium pentobarbital and the sleep latency and sleep time of each group of mice were recorded. Judging the basis: the phenomenon that the front turning reflection is in a sleep state does not occur within 1 min; the period from the time when pentobarbital sodium is injected into the abdominal cavity to the time when the eversion and the reflection disappear is a sleep latency period, and the time from the time when the eversion and the reflection disappear to the time when the reflection is restored is a sleep time.
The experimental results of the pentobarbital-induced sleep latency and the sleep time after the ICR mice inhale the compound essential oil are shown in table 5, and compared with the mice in the blank control group, the sleep latency of the mice in the positive control group has significant differences (P < 0.05) from the sleep latency of the mice in the positive control group for one day and the sleep latency of the mice in the positive control group for three days, so that the sleep latency of the mice can be significantly shortened; the sleep latency of each group of mice in one day group of aromatic south drug compound essential oil and the sleep latency of mice in the blank group of mice are not significantly different (P is more than 0.05), but the data still show that the aromatic south drug compound essential oil of the examples 1-3 can shorten the sleep latency to a certain extent; compared with mice in a blank control group, the sleep latency of the mice is obviously shortened (P < 0.05) in all the mice in the three-day group of aromatic south drug compound essential oil, which shows that the aromatic south drug compound essential oil of examples 1-3 has a trend of reducing the sleep latency of the mice along with the extension of the administration time and the increase of the administration times, and meanwhile, the aromatic south drug compound essential oil of examples 1-3 has no obvious difference in shortening the sleep latency.
From the aspect of sleep duration, compared with mice in a blank control group, the sleep duration of mice in a positive control group with one day and mice in a positive control group with three days is obviously prolonged (P < 0.05); the sleep duration of mice in one day group of aromatic south drug compound essential oil is obviously increased (P < 0.05), and the sleep duration of mice in three days group of aromatic south drug compound essential oil is obviously longer than the sleep duration of mice in one day group of aromatic south drug compound essential oil, which indicates that the aromatic south drug compound essential oil of examples 1-3 can obviously prolong the sleep duration of mice, and has the same change trend as the mice in diazepam group, and meanwhile, the aromatic south drug compound essential oil of examples 1-3 has no obvious difference in prolonging the sleep duration of mice.
Table 5 effects of aromatic nana drug Compound essential oil on sleep in mice (x±s, n=13) examples 1 to 3
Note that: each other group was compared to the blank group with P <0.05 and P <0.01.
While the embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. Furthermore, embodiments of the invention and features of the embodiments may be combined with each other without conflict.

Claims (6)

1. The compound essential oil is characterized by comprising the following components in parts by volume: 2-6 parts of butyl essential oil, 10-18 parts of cinnamon essential oil, 15-25 parts of wrinkled giant hyssop essential oil, 25-35 parts of sandalwood essential oil, 10-20 parts of fingered citron essential oil and 300-500 parts of base oil; the raw material of the wrinkled giant hyssop essential oil is fresh wrinkled giant hyssop; the fingered citron essential oil is prepared from fresh fingered citron; the preparation method of the sandalwood essential oil comprises the following steps: soaking and extracting sandalwood serving as a raw material and water serving as a solvent to obtain sandalwood essential oil; the soaking time is not less than 72 hours;
the compound essential oil is prepared by the following preparation method: mixing oleum Caryophylli, oleum Cinnamomi, herba Agastaches essential oil, lignum Santali albi essential oil and fructus Citri Sarcodactylis essential oil, aging, and mixing with base oil to obtain compound essential oil; the aging time is not less than 30 days.
2. The compound essential oil according to claim 1, wherein the preparation method of the patchouli essential oil is characterized in that fresh patchouli is used as a raw material, water is used as a solvent, and the patchouli essential oil is obtained by extraction.
3. The compound essential oil of claim 2, wherein the preparation method of the fingered citron essential oil comprises the following steps: fresh fingered citron is taken as a raw material, water is taken as a solvent, and fingered citron essential oil is obtained by extraction.
4. The compound essential oil according to any one of claims 1 to 3, wherein the base oil is at least one of jojoba oil, evening primrose seed oil, sweet almond oil, apricot kernel oil, avocado oil, wheat germ oil, macadamia nut oil and grape seed oil.
5. The use of the compound essential oil of any one of claims 1-4 in the preparation of a product.
6. A product comprising the compound essential oil of any one of claims 1-4.
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