CN114845996A - 一种含苯环的化合物及其应用 - Google Patents

一种含苯环的化合物及其应用 Download PDF

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CN114845996A
CN114845996A CN202080081732.1A CN202080081732A CN114845996A CN 114845996 A CN114845996 A CN 114845996A CN 202080081732 A CN202080081732 A CN 202080081732A CN 114845996 A CN114845996 A CN 114845996A
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independently
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CN114845996B (zh
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娄军
陈永凯
张轶涵
郭晓丹
钱丽娜
柳力
彭微
容飞
王朝东
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Wuhan LL Science and Technology Development Co Ltd
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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Abstract

提供一种如式I所示的含苯环的化合物、其药学上可接受的盐、其立体异构体、其互变异构体、其同位素化合物、其晶型、其氮氧化物、其溶剂合物或其药学上可接受的盐的溶剂合物，该化合物具有高的P2X4拮抗活性，且具有较好的选择性，毒性较低、代谢稳定性较好。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN202080081732.1A 2019-11-29 2020-11-27 一种含苯环的化合物及其应用 Active CN114845996B (zh)

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CN2019112031272 2019-11-29
CN201911203127 2019-11-29
PCT/CN2020/132418 WO2021104486A1 (zh) 2019-11-29 2020-11-27 一种含苯环的化合物及其应用

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EP (1) EP4053108A4 (zh)
JP (1) JP2023503682A (zh)
KR (1) KR20220134747A (zh)
CN (1) CN114845996B (zh)
AU (1) AU2020390377B2 (zh)
CA (1) CA3159689A1 (zh)
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CN114901642A (zh) * 2019-12-30 2022-08-12 武汉朗来科技发展有限公司 一种稠环化合物及其应用

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IL299383A (en) 2020-06-30 2023-02-01 Bayer Ag Use of N-phenylacetamides with P2X4 receptor antagonist activity to treat certain eye disorders

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CN109415321A (zh) * 2016-05-03 2019-03-01 拜耳制药股份公司 芳族磺酰胺衍生物

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US20160271131A1 (en) * 2005-09-01 2016-09-22 Roche Palo Alto Llc Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
CN102803245A (zh) * 2009-06-22 2012-11-28 弗·哈夫曼-拉罗切有限公司 作为p2x3和/或p2x2/3拮抗剂的新的吲哚、吲唑和苯并咪唑芳基酰胺类
CN104812393A (zh) * 2012-05-08 2015-07-29 默沙东公司 用于抑制RORγ活性和治疗疾病的四氢萘啶和相关双环化合物
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114901642A (zh) * 2019-12-30 2022-08-12 武汉朗来科技发展有限公司 一种稠环化合物及其应用
CN114901642B (zh) * 2019-12-30 2024-02-23 武汉朗来科技发展有限公司 一种稠环化合物及其应用

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CA3159689A1 (en) 2021-06-03
AU2020390377A1 (en) 2022-07-14
EP4053108A1 (en) 2022-09-07
AU2020390377B2 (en) 2023-12-21
JP2023503682A (ja) 2023-01-31
WO2021104486A1 (zh) 2021-06-03
KR20220134747A (ko) 2022-10-05
CN114845996B (zh) 2023-09-12
US20230183182A1 (en) 2023-06-15
EP4053108A4 (en) 2023-01-25

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