CN114767796A - Composition for erosive gastritis and preparation method thereof - Google Patents
Composition for erosive gastritis and preparation method thereof Download PDFInfo
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Abstract
The application provides a composition for erosive gastritis and a preparation method thereof, and relates to the technical field of medicines. The composition for erosive gastritis comprises the following raw materials in parts by weight: 100 portions of camphor pear 200 portions, 1-10 portions of sorghum, 1-10 portions of polished round-grained rice, 2-10 portions of almond, 1-10 portions of mulberry ear, 3-12 portions of red bean, 5-15 portions of millet, 1-11 portions of walnut kernel and 5-12 portions of dried orange peel. The composition of the application can treat erosive gastritis and can effectively prevent early gastric cancer through combined action of inhibiting or killing helicobacter pylori, protecting and repairing gastric mucosa and regulating pepsin level. In the preparation method of the composition, different medicinal materials are pretreated and mixed and extracted by a plurality of methods, so that medicinal components of the medicine are better separated out, and the gastritis is better treated.
Description
Technical Field
The application relates to the technical field of medicines, in particular to a composition for erosive gastritis and a preparation method thereof.
Background
Gastritis (gastronitis) is a gastric mucositis caused by various causes and is one of the most common digestive diseases. According to the clinical onset of the disease, the disease can be generally divided into two types of acute gastritis and chronic gastritis; it can be classified into helicobacter pylori related gastritis, stress gastritis, autoimmune gastritis, etc. according to the cause of disease. Gastritis, which is caused by different etiologies, is also different in its pathological changes, and generally includes three processes, namely, epithelial injury, mucosal inflammatory response, and epithelial regeneration. Acute gastritis can be classified into simple gastritis, erosive gastritis, purulent gastritis, etc. according to its pathological changes, and chronic gastritis can be classified into non-atrophic gastritis, atrophic gastritis and special gastritis.
Gastric erosion generally refers to gastric ulcer, which is one of peptic ulcers that occur in the gastric horn, antrum, cardia, and hiatal hernia. Gastric ulcers are formed by the autodigestion of the mucosa by gastric acid and pepsin.
At present, western medicines are generally used for relieving treatment, but the western medicines have poor curative effect on part of patients, clinical symptoms are easy to relapse after the medicine is stopped, the tolerance is strong, the side effect is large after long-term use, and vicious circle is easy to form.
Disclosure of Invention
The application aims to provide a composition for treating erosive gastritis, which can treat erosive gastritis and effectively prevent early gastric cancer by combined action of inhibiting or killing helicobacter pylori, protecting and repairing gastric mucosa and regulating pepsin level.
The other purpose of the application is to provide a preparation method of the composition for erosive gastritis, which is characterized in that different medicinal materials are pretreated and mixed and extracted by multiple methods, so that medicinal components of the medicinal materials are better separated out, and the gastritis can be better treated.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
The application provides a composition for erosive gastritis, which comprises the following raw materials in parts by weight: 100 portions of camphor pear 200 portions, 1-10 portions of sorghum, 1-10 portions of polished round-grained rice, 2-10 portions of almond, 1-10 portions of mulberry ear, 3-12 portions of red bean, 5-15 portions of millet, 1-11 portions of walnut kernel and 5-12 portions of dried orange peel.
The application provides a preparation method of a composition for erosive gastritis, which comprises the following steps:
adding a mixed solvent of ethanol and methanol into the camphor pear, and performing microwave extraction to obtain an extracting solution; mixing the rest materials, adding water, and decocting to obtain decoction; mixing the extractive solutions and the decoction, centrifuging, concentrating, and drying.
The embodiment of the application has at least the following beneficial effects:
according to the application, the camphor pear is used as a main raw material, and other raw materials such as sorghum, polished round-grained rice and almonds are used as auxiliary materials, so that the distribution of gastric flora is improved, the breeding of bacteria is inhibited, gastric cells are protected, the repair of gastric mucosa is accelerated, flatulence can be prevented and treated, the health of the stomach is protected, the health of a human body is maintained, and the effects of warming the middle warmer and harmonizing the stomach, and inducing diuresis to alleviate pain are achieved; can also reduce gastric acid secretion, reduce free acidity and total acidity of gastric juice, inhibit activity of pepsin, protect gastric mucosa, promote gastric mucosa repair, and protect gastric mucosa barrier. The traditional Chinese medicine composition is reasonable in proportion, has the effects of tonifying spleen and stomach, strengthening middle warmer and replenishing qi, and strengthening spleen to promote digestion, can effectively reduce gastric acid, regulate the level of pepsin, supplement each other, and take effect synergistically, can treat gastritis and gastric erosion from multiple aspects, is beneficial to comprehensive rehabilitation of patients, and can also effectively prevent gastric cancer.
The preparation method of the composition is simple, different medicinal materials are pretreated, and the medicinal components are extracted by mixing a plurality of methods, so that the medicinal component precipitation effect is better, the loss of effective components can be reduced as much as possible, the medicinal effect is enhanced, the curative effect of the composition is better, and the effect is quicker.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The composition for erosive gastritis comprises the following raw materials in parts by weight: 100 portions of camphor pear 200 portions, 1-10 portions of sorghum, 1-10 portions of polished round-grained rice, 2-10 portions of almond, 1-10 portions of mulberry ear, 3-12 portions of red bean, 5-15 portions of millet, 1-11 portions of walnut kernel and 5-12 portions of dried orange peel.
The camphor pear has pungent and warm taste, is warm in nature, enters stomach and liver meridians, has the effects of invigorating stomach, warming middle energizer, regulating qi to alleviate pain, and is mainly used for treating stomach cold, abdominal pain, dyspepsia, abdominal distension, vomiting and diarrhea; it is used externally to treat sore and swelling.
Sorghum is sweet in taste, warm in nature and astringent, enters spleen and stomach channels, has the main effects of tonifying qi, strengthening spleen, nourishing stomach and checking diarrhea, is suitable for infantile dyspepsia and qi deficiency of spleen and stomach, and is mainly used for treating spleen deficiency damp encumbering, damp-heat diarrhea, dysuria and other symptoms. The sorghum contains magnesium element, and can regulate the activity of cardiac muscle of human body, promote fibrinolysis of human body and reduce the occurrence of cardiovascular diseases. The calcium component in sorghum can promote the growth and development of human skeleton. Sorghum is cool in nature, has the effects of cooling blood, detoxifying, harmonizing stomach, tonifying spleen and checking diarrhea, and can be used for treating various diseases such as dyspepsia, food retention, damp-heat diarrhea, dysuria and the like. The sorghum can delay the rise of blood sugar, and can be properly eaten by diabetics.
The polished round-grained rice is sweet and light in taste and mild in nature, and has the effects of strengthening spleen and stomach, tonifying middle-jiao and Qi, relieving diarrhea and dysentery and removing polydipsia. The rice contains excellent protein, and can keep blood vessel soft and reduce blood pressure. The japonica rice contains vitamin B1, protein, vitamin E, dietary fiber and other nutrients. The polished round-grained rice is especially suitable for people with deficiency of spleen-stomach qi, lassitude, hypodynamia, vexation, thirst, poor appetite and anorexia.
The almond has the function of health care, and can enhance the cognitive ability of human bodies, protect memory and delay brain aging. The almond has the functions of relieving cough and asthma, relaxing bowel, treating lung disease and cough and the like, contains rich brass, polyphenol and other components, can reduce the content of cholesterol in a human body, and can reduce the occurrence of heart disease and chronic diseases. The almond has the functions of maintaining beauty and keeping young, and promoting skin microcirculation to make the skin ruddy and glossy. The almond contains a large amount of cellulose, can enhance satiety, and has the effects of moistening lung, clearing heat, relaxing bowels and expelling toxin.
Mulberry ear, with sweet flavor, enters liver and spleen meridians, can cool blood, stop bleeding, activate blood and dissipate nodulation, and is mainly used for treating epistaxis, hematuria, hematochezia, hemorrhoidal bleeding, metrorrhagia and metrostaxis, pharyngitis, abdominal mass and the like. The phellinus igniarius is also called phellinus igniarius, can benefit five internal organs, ventilate intestines and stomach qi, expel toxin and qi, and phellinus igniarius polysaccharide can relieve symptoms such as pain, inappetence, weight loss, fatigue and lassitude, is a bioactive substance capable of enhancing the immune function of a human body, and has the functions of resisting tumor, regulating immunity, reducing blood pressure and blood fat, resisting thrombus, invigorating stomach and protecting liver, resisting oxidation, resisting radiation, resisting ulcer, resisting aging, resisting virus, reducing blood sugar and the like. Phellinus igniarius flavonoids have effects in improving cardiovascular and cerebrovascular circulation, scavenging free radicals, resisting aging, inhibiting lipid peroxidation, resisting platelet aggregation, preventing capillary penetration, protecting skin, resisting cancer, bacteria, virus, liver toxicity, and allergy, and improving immunity. Phellinus linteus terpenoids have hemolytic, blood lipid reducing, blood pressure lowering, anti-tumor, anticancer, liver protecting, HIV-1 and HIV-1 protease activity resisting, antiinflammatory, antibacterial, anti-HIV, and contraceptive effects. Phellinus igniarius proteins, polypeptides, amino acids, trace elements and the like can enhance human immunity. In addition, Phellinus linteus also has antitumor effect, can inhibit proliferation or growth of tumor cells, and has no toxicity to normal cells.
The red bean is rich in protein, fat, carbohydrate, crude fiber, ash, calcium, phosphorus, iron, vitamin B1, vitamin B2, vitamin B3 and the like, and is beneficial to enhancing the immune function of the body and improving the disease resistance; is rich in dietary fiber, and has effects of loosening bowel to relieve constipation, lowering blood pressure, reducing blood lipid, regulating blood sugar, removing toxic substance, resisting cancer, and preventing calculus; contains saponin, and has diuretic, anti-hangover, and toxic materials clearing away effects.
The millet can supplement carbohydrate, namely sugar, for the organism, so that glycogen in muscles can be timely supplemented, and the effects of relieving muscle fatigue and recovering physical strength are very obvious; has good effects of regulating the middle warmer and tonifying the kidney by nourishing the kidney channel for people with deficiency heat of the spleen and the stomach, repeated vomiting, abdominal fullness, poor appetite, soreness and weakness of waist and knees and lumbocrural pain. The millet has high iron content and can enrich the blood. In addition, it can also supplement vitamin B1.
The semen Juglandis has effects of loosening bowel to relieve constipation and promoting digestion, and can be used for treating constipation. The walnut kernel also has the effects of supplementing brain cells and delaying aging, is more suitable for middle-aged people to eat, and can promote brain development. The walnut kernel also has the effects of promoting sleep and improving sleep quality, and is helpful for treating insomnia.
Pericarpium Citri Tangerinae, with warm nature and bitter and pungent taste, enters lung and spleen channels, has effects of regulating qi and invigorating spleen, eliminating dampness and eliminating phlegm, can be used for treating qi stagnation of spleen and stomach, abdominal distention and pain, nausea and emesis, diarrhea, abdominal distention and pain caused by food stagnation, abdominal pain and massage, anorexia, loose stool caused by spleen deficiency and qi stagnation, and can also be used for treating emesis, singultus, damp phlegm, cough with cold phlegm, thoracic obstruction, etc. The bitter substances of pericarpium Citri Tangerinae are "limonoids" represented by limonin and bitter principle, which have mild taste, are easily dissolved in water, and are helpful for digestion of food. The pericarpium Citri Tangerinae contains volatile oil, hesperidin, vitamin B, C, etc., and the volatile oil has mild irritation to gastrointestinal tract, and can promote secretion of digestive juice, eliminate intestinal qi accumulation, and stimulate appetite.
The camphor pear is used as a main raw material, and other raw materials such as sorghum, polished round-grained rice, almond and the like are used as auxiliary materials, so that the camphor pear is beneficial to improving the distribution of gastric flora, inhibiting bacterial breeding, protecting gastric cells, accelerating the repair of gastric mucosa, preventing and treating flatulence, protecting the health of the stomach, being beneficial to maintaining the health of a body and playing roles of warming the middle-jiao and harmonizing the stomach, benefiting qi and relieving pain; can also reduce gastric acid secretion, reduce free acidity and total acidity of gastric juice, inhibit activity of pepsin, protect gastric mucosa, promote gastric mucosa repair, and protect gastric mucosa barrier. The formula is reasonable, has the effects of tonifying spleen and stomach, strengthening middle-jiao and replenishing qi, strengthening spleen and promoting digestion, can effectively reduce gastric acid, regulate the level of pepsin, supplement each other and take effect synergistically, treats erosive gastritis from multiple aspects, is beneficial to the overall rehabilitation of patients, and can also effectively prevent gastric cancer.
In this embodiment, the composition for erosive gastritis further comprises 1-5 parts by weight of pinellia ternate and 0.5-4 parts by weight of endothelium corneum gigeriae galli.
Pinellia ternate is pungent in taste, warm in nature and toxic in toxicity, enters spleen, stomach and lung channels, has the effects of eliminating dampness and phlegm, lowering adverse qi and preventing vomiting, dissolving lumps and dissipating stagnation and the like, and is used for treating damp phlegm and cold phlegm, cough and asthma with excessive phlegm, phlegm retention and dizziness and palpitation, wind phlegm dizziness, phlegm syncope and headache, vomiting and regurgitation, chest and epigastric stuffiness and oppression and plum stone; it is indicated for abscess with phlegm nodule. It mainly contains volatile oil, a small amount of fat, starch, alkaloid, mucus, amino acid, beta-sitosterol, choline and dihydroxybenzaldehyde, has the effects of relieving cough, inhibiting glandular secretion, stopping vomiting, promoting vomiting and the like, and has obvious resisting effect on experimental ventricular arrhythmia and premature ventricular contraction; has remarkable gastric secretion inhibiting effect; has remarkable prevention and treatment effects on gastric ulcer.
The endothelium corneum Gigeriae Galli mainly contains gastric hormone, keratin, trace pepsin, amylase, multiple vitamins and minerals, and 18 amino acids, and has effects of regulating gastrointestinal function, resisting blood coagulation, and regulating blood lipid.
The pinellia ternate, the endothelium corneum gigeriae galli and the raw materials are matched, so that the inhibition effect of gastric secretion can be enhanced, the gastrointestinal function can be enhanced and regulated, the gastrointestinal function is recovered to be normal, the gastric mucosa is protected, the pepsin level is reduced, and the gastric erosion is effectively treated.
In this embodiment, the composition for erosive gastritis further comprises, by weight, 0.1-2 parts of dendrobium and 1-6 parts of clove.
The dendrobium nobile is sweet in taste and slightly cold in nature, enters stomach and kidney meridians, and has the effects of tonifying stomach, promoting fluid production, nourishing yin and clearing heat. The dendrobium has certain antipyretic and analgesic effects, can promote gastric secretion, enhance small intestine peristalsis, promote digestion, enhance metabolic capability, and is favorable for softening excrement and defecation; the gastrointestinal peristalsis can be promoted, the absorption capacity of the stomach is improved, and the gastric mucosa is helped to be repaired; the immunity can be enhanced, the invasion of viruses can be resisted, and the disease incidence can be reduced; the contained polysaccharide has the functions of resisting cell mutation and clearing aging and injured cells in vivo, can stabilize the physiological state of an organism and has stronger antitumor activity; can obviously improve the levels of superoxide dismutase and HYP in human bodies and obviously reduce the oxidation function of the organisms, thereby playing the role of resisting aging.
Clove, pungent in flavor and warm in nature, enters stomach, spleen and kidney meridians, and has the effects of warming middle energizer, lowering adverse qi, tonifying kidney and supporting yang. Flos Caryophylli has effects of resisting gastric ulcer, relieving diarrhea, promoting bile flow, relieving pain, resisting anoxia, resisting blood coagulation, resisting mutation, inhibiting bacteria, and killing parasite. Clove also has the efficacy and function of invigorating stomach, and the leaching solution has obvious function of stimulating gastric secretion and can relieve abdominal distension, nausea, vomiting and the like. In addition, flos Caryophylli has inhibitory effect on pathogenic fungi, coccus, streptococcus, Bacillus such as pneumonia, dysentery, large intestine, typhoid, etc., and influenza virus. The main component eugenol of clove has the activities of bacteriostasis, anesthesia, fever reduction, oxidation resistance and tumor resistance, can inhibit or kill helicobacter pylori, and can effectively resist the invasion and breeding of the helicobacter pylori.
The dendrobium and the clove are matched with the raw materials, so that the dendrobium and the clove are beneficial to improving the distribution of gastric flora, inhibiting the breeding of bacteria, protecting gastric cells, accelerating the repair of gastric mucosa, preventing flatulence, protecting the health of the stomach, being beneficial to maintaining the health of the body and playing the roles of warming the middle-jiao and harmonizing the stomach, and benefiting qi and relieving pain.
In this embodiment, the composition for erosive gastritis further includes 2-10 parts by weight of peony and 1-4 parts by weight of bletilla striata.
Paeonia lactiflora pall, bitter and sour in taste and slightly cold in nature, has the functions of calming the liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating, and is mainly used for treating headache, dizziness, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, chlorosis, irregular menstruation, spontaneous perspiration and night sweat. Radix Paeoniae has effects of inhibiting gastric secretion, resisting inflammation and bacteria, and protecting gastric mucosa.
Bletilla striata, bitter, sweet, astringent in taste, slightly cold in nature, enters lung, liver and stomach meridians, and has the functions of astringing to stop bleeding, relieving swelling and promoting granulation. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin; pulmonary tuberculosis hemoptysis, ulcer hemorrhage. Bletilla striata is highly viscous and may form a jelly-like film of a certain thickness in the stomach, thereby blocking the perforations and stopping the outflow of stomach contents. Bletilla striata can stimulate the gastric mucosa to synthesize and release endogenous prostaglandin, thereby protecting the gastric mucosa.
The peony, the bletilla striata and the raw materials are matched, the purpose of protecting the gastric mucosa is achieved through inhibiting gastric secretion, resisting inflammation and resisting bacteria, the effect of protecting the gastric mucosa is further enhanced through stimulating the synthesis and the release of endogenous prostaglandin by the gastric mucosa, the gastric mucosa is effectively prevented from being damaged, and the treatment effect on erosive gastritis is improved.
A preparation method of a composition for erosive gastritis comprises the following steps:
adding a mixed solvent of ethanol and methanol into the camphor pear, and performing microwave extraction to obtain an extracting solution; mixing the rest materials, adding water, and decocting to obtain decoction; mixing the extractive solutions and the decoction, centrifuging, concentrating, and drying.
The preparation method of the composition is simple, the medicinal components of the medicine are better separated out by pretreating different medicinal materials and mixing and extracting by a plurality of methods, and the loss of the effective components can be reduced as much as possible, so that the medicine effect is enhanced, the curative effect of the composition is better, and the effect is quicker.
In this example, the volume ratio of ethanol to methanol in the mixed solvent was (2-5): 0.5. when the mixed solvent uses, methyl alcohol and ethanol combined action, be favorable to extracting as much as possible the active ingredient in the camphor pear, ethanol is volatile by the temperature influence, under the effect of methyl alcohol, the stability of ethanol is better, thereby can let inside ethanol can permeate into the camphor pear better faster, back and forth movement through methyl alcohol and ethanol, make the active ingredient in the camphor pear taken out, both cooperate the back, can show the extraction rate that improves camphor pear active ingredient.
In the embodiment, during microwave extraction, the extract is firstly extracted at 70-80 ℃ for 20-30min and then extracted at 40-50 ℃ for 30-40 min. The extraction is carried out at a higher temperature, so that the movement rate of the mixed solvent can be increased, the mixed solvent can permeate into the camphor pear more quickly, and the effective components in the camphor pear can be separated out more quickly; and then extracting at low temperature, so that the motion state of the mixed solvent can be changed, and the equilibrium state of the effective components during precipitation is broken, thereby being more beneficial to extracting the effective components in the camphor pear and improving the content of the effective components.
In this embodiment, after mixing the rest raw materials, before adding water, parching at 90-100 deg.C for 5-10min is also included. Therefore, the internal structures of the components can be loosened, so that the effective components can be more easily separated out during decoction, the extraction rate is improved, and the content of the effective components is increased.
In the embodiment, the decoction is carried out for 2-4h at 90-110 ℃.
In this embodiment, the centrifugation is performed at 1000r/min of 800-. After drying, the composition can be prepared into granules, powder, pills, capsules and the like.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 200g of camphor pear, 10g of sorghum, 10g of polished round-grained rice, 10g of almond, 10g of mulberry, 10g of small red bean, 10g of millet, 10g of walnut kernel and 10g of dried orange peel;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 3: 0.5, microwave extracting, namely extracting at 80 ℃ for 30min and then at 50 ℃ for 40min to obtain an extracting solution; mixing the rest materials, parching at 100 deg.C for 10min, adding water, and decocting at 110 deg.C for 4 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 1000r/min for 10min, concentrating, and spray drying at 60 deg.C until water content is less than 5%.
Example 2
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 100g of camphor pear, 1g of sorghum, 1g of polished round-grained rice, 2g of almond, 1g of mulberry ear, 3g of small red bean, 5g of millet, 1g of walnut kernel and 5g of dried orange peel;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 2: 0.5, microwave extracting, namely extracting for 20min at 70 ℃ and then extracting for 30min at 40 ℃ to obtain an extracting solution; mixing the rest materials, parching at 90 deg.C for 5min, adding water, and decocting at 90 deg.C for 2 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 800r/min for 5min, concentrating, and spray drying at 50 deg.C until water content is less than 5%.
Example 3
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 150g of pinto pear, 5g of sorghum, 5g of polished round-grained rice, 5g of almond, 5g of mulberry, 5g of small red bean, 7g of millet, 5g of walnut kernel and 8g of dried orange peel;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 5: 0.5, microwave extracting, namely extracting at 75 ℃ for 25min and then at 45 ℃ for 35min to obtain an extracting solution; mixing the rest materials, parching at 95 deg.C for 8min, adding water, and decocting at 100 deg.C for 3 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 900r/min for 8min, concentrating, and spray drying at 55 deg.C until water content is less than 5%.
Example 4
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 120g of camphor pear, 2g of sorghum, 3g of polished round-grained rice, 4g of almond, 2g of mulberry leaf, 4g of small red bean, 6g of millet, 2g of walnut kernel, 8g of dried orange peel, 2g of pinellia tuber and 1g of chicken's gizzard-membrane;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 4: 0.5, microwave extracting, namely extracting for 22min at 78 ℃, and then extracting for 33min at 46 ℃ to obtain an extracting solution; mixing the rest materials, parching at 98 deg.C for 6min, adding water, and decocting at 105 deg.C for 3 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 850r/min for 6min, concentrating, and spray drying at 54 deg.C until water content is less than 5%.
Example 5
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 120g of camphor pear, 2g of sorghum, 3g of polished round-grained rice, 4g of almond, 2g of mulberry, 4g of small red bean, 6g of millet, 2g of walnut kernel, 8g of dried orange peel, 2g of pinellia ternate, 1g of chicken's gizzard-membrane, 1g of dendrobium and 3g of clove;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 4: 0.5, microwave extracting, namely extracting for 22min at 78 ℃, and then extracting for 33min at 46 ℃ to obtain an extracting solution; mixing the rest materials, parching at 98 deg.C for 6min, adding water, and decocting at 105 deg.C for 3 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 850r/min for 6min, concentrating, and spray drying at 54 deg.C until water content is less than 5%.
Example 6
A preparation method of a composition for erosive gastritis comprises the following steps:
raw materials: 120g of camphor pear, 2g of sorghum, 3g of polished round-grained rice, 4g of almond, 2g of mulberry, 4g of small red bean, 6g of millet, 2g of walnut kernel, 8g of dried orange peel, 2g of pinellia ternate, 1g of chicken's gizzard-membrane, 1g of dendrobium, 3g of clove, 5g of peony and 3g of bletilla striata;
adding a mixed solvent of ethanol and methanol into the camphor pears, wherein the volume ratio of the ethanol to the methanol is 4: 0.5, microwave extracting, namely extracting for 22min at 78 ℃, and then extracting for 33min at 46 ℃ to obtain an extracting solution; mixing the rest materials, parching at 98 deg.C for 6min, adding water, and decocting at 105 deg.C for 3 hr to obtain decoction; mixing extractive solutions and decoctions, centrifuging at 850r/min for 6min, concentrating, and spray drying at 54 deg.C until water content is less than 5%.
Comparative example 1
The comparative example is different from example 1 in that camphor pear is not added to the raw materials. The preparation method of the composition for erosive gastritis is the same as in example 1.
Comparative example 2
The comparative example is different from example 1 in that microwave extraction is carried out on the camphor pear by using ethanol only, and the rest of raw materials and operation steps are the same as example 1.
Test results
40 chronic erosive gastritis testers are selected and randomly divided into 8 groups, and each group comprises 5 persons, and the clinical manifestations of the chronic erosive gastritis are nonspecific dyspepsia, such as epigastric vague pain, acid regurgitation, postprandial fullness and anorexia. The endoscopic examination shows that the gastritis is erosive and swelling type.
The test method comprises the following steps: 1-8 groups correspond to the use of the compositions of examples 1-6 and comparative examples 1-2, respectively, 3 times per day, 1 time with 10g, and 1 month of continuous administration.
The subjects were allowed to score themselves after administration, with the following symptom grading criteria:
TABLE 1 symptom Scoring criteria
TABLE 2 scoring results
Note: the scoring results of each group are the average value of each group, and the higher the score is, the better the treatment effect is.
As can be seen from Table 2, the higher scores of the subjects of the groups of examples 1 to 6 indicate that the compositions of examples 1 to 6 have better effects on the treatment of chronic erosive gastritis. The lower score of comparative example 1 indicates that the composition without the addition of the camphor pear has a poor treatment effect on erosive gastritis. Comparative example 2 shows that the composition obtained by performing microwave extraction on the camphor pear by using the mixed solvent has a better treatment effect on erosive gastritis.
In summary, the composition for erosive gastritis in the embodiment of the application takes the camphor pear as a main raw material and other raw materials such as sorghum, polished round-grained rice and almond as auxiliary materials, so that the composition is beneficial to improving the distribution of gastric flora, inhibiting bacterial growth, protecting gastric cells, accelerating the repair of gastric mucosa, preventing and treating flatulence, protecting the health of the stomach, being beneficial to maintaining the health of the body, and playing roles in warming the middle-jiao and harmonizing the stomach, and benefiting qi and relieving pain; can also reduce gastric acid secretion, reduce free acidity and total acidity of gastric juice, inhibit activity of pepsin, protect gastric mucosa, promote gastric mucosa repair, and protect gastric mucosa barrier. The traditional Chinese medicine composition is reasonable in proportion, has the effects of tonifying spleen and stomach, strengthening middle-jiao and replenishing qi, and strengthening spleen and helping digestion, can effectively reduce gastric acid, adjusts the level of pepsin, supplements each other, takes effect synergistically, treats gastric erosion from multiple aspects, is beneficial to comprehensive rehabilitation of patients, and can also effectively prevent gastric cancer.
The preparation method of the composition for erosive gastritis, which is provided by the embodiment of the application, is simple to operate, and through pretreatment and mixed extraction of different medicinal materials by various methods, medicinal components of the medicine are better separated out, loss of effective components can be reduced as much as possible, so that the medicine effect is enhanced, the curative effect of the composition is better, and the effect is faster.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. The composition for erosive gastritis is characterized by comprising the following raw materials in parts by weight: 100 portions of camphor pear 200 portions, 1-10 portions of sorghum, 1-10 portions of polished round-grained rice, 2-10 portions of almond, 1-10 portions of mulberry ear, 3-12 portions of red bean, 5-15 portions of millet, 1-11 portions of walnut kernel and 5-12 portions of dried orange peel.
2. The composition for erosive gastritis of claim 1, further comprising 1-5 parts by weight of pinellia ternate and 0.5-4 parts by weight of endothelium corneum gigeriae galli.
3. The composition for erosive gastritis of claim 2, further comprising, by weight, 0.1-2 parts of herba Dendrobii and 1-6 parts of flos Caryophylli.
4. The composition for erosive gastritis of claim 3, further comprising 2-10 parts by weight of Paeonia lactiflora and 1-4 parts by weight of bletilla striata.
5. A method for preparing the composition for erosive gastritis as defined in any of claims 1-4, comprising the steps of:
adding a mixed solvent of ethanol and methanol into the camphor pears, and performing microwave extraction to obtain an extracting solution; mixing the rest materials, adding water, and decocting to obtain decoction; mixing the extractive solutions and the decoction, centrifuging, concentrating, and drying.
6. The production method according to claim 5, wherein the volume ratio of ethanol to methanol in the mixed solvent is (2-5): 0.5.
7. the method of claim 6, wherein the microwave extraction is carried out at 70-80 deg.C for 20-30min, and at 40-50 deg.C for 30-40 min.
8. The method of claim 7, wherein the step of parching the mixture of the remaining ingredients at 90-100 deg.C for 5-10min is further included before adding water.
9. The preparation method according to claim 8, wherein the decoction is carried out at 90-110 deg.C for 2-4 hr.
10. The method as claimed in claim 9, wherein the centrifugation is performed at 1000r/min at 800-10 min, and the drying is performed by spray drying at 50-60 ℃ until the water content is less than 5%.
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| CN101306180A (en) * | 2008-06-10 | 2008-11-19 | 王立财 | Gastropathy treating medicine |
| CN105687425A (en) * | 2016-03-17 | 2016-06-22 | 袁尊山 | Capsule preparation for treating epigastralgia |
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