CN107913372A - A kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis - Google Patents

A kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis Download PDF

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CN107913372A
CN107913372A CN201710280492.8A CN201710280492A CN107913372A CN 107913372 A CN107913372 A CN 107913372A CN 201710280492 A CN201710280492 A CN 201710280492A CN 107913372 A CN107913372 A CN 107913372A
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张晓丽
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Abstract

The present invention relates to a kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis, the raw material composition that the Chinese and western medicinal composition active ingredient is made is：Water chestnut, bamboo root seven, climbing fig, glabrousleaf pittosporum root, phoenix tree leaf, Shuo Di, Chinese sumac root, variegated leaf orchid, holly leaf, old rice, hawthorn, farges fir cone, cinnarizine, ligustrazine；The traditional Chinese medical science and western medicine therapy are combined by Chinese and western medicinal composition of the present invention, all medicine phases close with promoting blood circulation, the powdered medicine ' Tongluosan ' stasis of blood, tonify Qi of the kidney, tranquilizing the mind, calming the liver to stop the wind, blood pressure lowering, hard muscles and bones, promoting blood circulation, Qi Yang roads and other effects, it can play the role of conserving the internal organs such as the heart, the liver,spleen,kidney of Cerebral thrombosis patient while Cerebral thrombosis is treated, it is curative for effect for treatment Cerebral thrombosis, it is quick, in the side of choosing, the present invention has certain novelty, has certain social economic value.

Description

A kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of Chinese and western medicinal composition and system for treating Cerebral thrombosis Preparation Method.
Background technology
Cerebral thrombosis is the most common type of cerebral infarction.It is that cerebral artery trunk or cortical branches atherosclerosis cause blood Pipe thickens, luminal stenosis is inaccessible and thrombosis, causes brain regional blood flow reduction or blood supply to be interrupted, brain tissue ischemia anoxic causes , there is focal neurological symptom sign in softening necrosis, so atherosclerotic cerebral thrombus is clinically also known as, or blood Bolt cerebral infarction.
Cerebral thrombosis is more common in person in middle and old age, and person caused by arteritis is often sent out with young and middle-aged common in quiet or sleep Disease, some cases have TIA premonitory symptoms such as extremity numbness, powerless etc., focal sign more more than 10 hours or 1-2 days after morbidity Peak, patient's Clear consciousness or have mild cognitive obstacle.
Cerebral thrombosis classical symptom have it is slow in reacting, feel excessively, sensory disturbance, high fever, hypertension, swallow it is tired It is difficult, powerless.Cerebral thrombosis not only causes great threat to mankind's health and lives, but also to patient, family and social band Come greatly pain and white elephant.
China progresses into aging society, and cranial vascular disease incidence is in increase trend.Its disability rate, case fatality rate are very Height, huge economic expenditure become an important social concern.Cardiovascular and cerebrovascular disease is classified as by the World Health Organization endangers the mankind First killer of health.According to statistics, about 32% people dies of the disease of cardiovascular and cerebrovascular in annual death, not only right The health of the mankind causes greatly to threaten, and has also aggravated the burden of society.
Though the treatment of Cerebral thrombosis has very big progress in recent years, but still cannot solve all Cerebral thrombosis How the problem that disables of patient, make patient is medical etc. as early as possible to ask after also there is the generation and generation for how avoiding Cerebral thrombosis Topic, and at present in terms of the treatments such as neuroprotection, anti-freezing, traditional Chinese medicine without unified standard.
The content of the invention
The present invention provides a kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis；In the present invention
The traditional Chinese medical science and western medicine therapy are combined by Western medicine compound, all medicine phases close with promoting blood circulation, the powdered medicine ' Tongluosan ' stasis of blood, tonify Qi of the kidney, Tranquilizing the mind, calming the liver to stop the wind, blood pressure lowering, hard muscles and bones, promoting blood circulation, Qi Yang roads and other effects, can be in treatment Cerebral thrombosis Play the role of conserving the internal organs such as the heart, the liver,spleen,kidney of Cerebral thrombosis patient at the same time, treated for treatment Cerebral thrombosis Imitate definitely, quick, in the side of choosing, the present invention has certain novelty, has certain social economic value.
To achieve the above object, technical scheme is implemented as follows：
A kind of Chinese and western medicinal composition for treating Cerebral thrombosis, the Chinese and western medicinal composition active ingredient, which is made, includes Chinese medicine group Divide and western medicine component, the traditional Chinese medicinal components are formulated by the raw material of following weight number：It is effective that the Chinese and western medicinal composition is made Component includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are formulated by the raw material of following weight number：Water chestnut 48-60g, Seven 41-53g of bamboo root, climbing fig 41-53g, glabrousleaf pittosporum root 38-50g, phoenix tree leaf 35-47g, Shuo Di 28-40g, Chinese sumac root 28-40g, Variegated leaf orchid 26-38g, holly leaf 23-31g, old rice 16-21g, hawthorn 16-21g, farges fir cone 12-17g；The western medicine component by The raw material of following weight number is formulated：Cinnarizine 0.1-0.5g, ligustrazine 0.5-1g.
The Chinese and western medicinal composition active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are by following The raw material of weight number is formulated：Water chestnut 57g, seven 50g of bamboo root, climbing fig 50g, glabrousleaf pittosporum root 47g, phoenix tree leaf 44g, Shuo Di 37g, salt Wheat bran root 37g, variegated leaf orchid 35g, holly leaf 29g, old rice 19g, hawthorn 19g, farges fir cone 16g；The western medicine component is by following The raw material of weight number is formulated：Cinnarizine 0.4g, ligustrazine 0.8g.
The Chinese and western medicinal composition active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are by following The raw material of weight number is formulated：Water chestnut 54g, seven 47g of bamboo root, climbing fig 47g, glabrousleaf pittosporum root 44g, phoenix tree leaf 41g, Shuo Di 34g, salt Wheat bran root 34g, variegated leaf orchid 32g, holly leaf 27g, old rice 18g, hawthorn 18g, farges fir cone 14g；The western medicine component is by following The raw material of weight number is formulated：Cinnarizine 0.3g, ligustrazine 0.7g.
The Chinese and western medicinal composition active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are by following The raw material of weight number is formulated：Water chestnut 51g, seven 44g of bamboo root, climbing fig 44g, glabrousleaf pittosporum root 41g, phoenix tree leaf 38g, Shuo Di 31g, salt Wheat bran root 31g, variegated leaf orchid 29g, holly leaf 25g, old rice 17g, mountain
Short, bristly hair or beard 17g, farges fir cone 13g；The western medicine component is formulated by the raw material of following weight number：Cinnarizine 0.2g, ligustrazine 0.6g。
A kind of preparation method for the Chinese and western medicinal composition for treating Cerebral thrombosis, comprises the following steps that：
(1) water chestnut is removed into tender shoots, ground, leaching white juice, is precipitated, dry, obtains 180 targeted fine powders, spare；
(2) bamboo root seven, glabrousleaf pittosporum root, phoenix tree leaf, Chinese sumac root, old rice, hawthorn and farges fir cone are put into container, add 10 times Measure distilled water immersion 4 it is small when after, heating boil 4 it is small when, extraction；Second add 8 times of amount distilled water heating boil 3 it is small when, carry Take；Third time add 6 times amount distilled water heating boil 2 it is small when, extraction；Merge gained extracting solution three times, filtration, it is standby to obtain filtrate With；
(3) by climbing fig He Shuo Di enter in juice extractor to squeeze the juice, filtering, deoxidation, vacuum freeze drying, obtained 160 targeted fine powders, standby With；
(4) by variegated leaf is blue and holly leaf immerse 10 times of amount volumetric concentrations, 70% alcohol solution dipping 4 it is small when, heating extraction, filtration, After standing, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 thick paste it is spare；
(5) cinnarizine is dissolved in the 117-127o boiling ethanol of 0.5 times of amount, obtains solution for standby；
(6) ligustrazine is added to 80-85 ° of hot water dissolving of 6-10 times of weight, obtains solution for standby；
(5) fine powder of above-mentioned gained, filtrate, thick paste and solution are mixed, the distilled water of 10 times of amounts is added, under 121 DEG C of hot pressing Sterilizing 30 minutes, is made the tablet of 0.4g/ pieces, packs according to a conventional method, is the treatment Cerebral thrombosis Chinese and western medicinal composition.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Water chestnut：It is sweet in flavor, it is cold in nature；Attach to the lung and stomach meridians.Clearing heat and promoting fluid, resolving sputum, disperse accumulation.Main warm disease is thirsty, abscess of throat, phlegm-heat cough, Hot eyes, quenches one's thirst, dysentery, jaundice, heat gonorrhea, dyspepsia, wart.《Book on Chinese herbal medicine is new again》Carry：" clearing heart fire, tonifying lung cool liver, eliminates indigestion and phlegm, It is broken stagnant, sharp purulence blood.”
Bamboo root seven：Sweet in flavor, micro-pungent, it is mild-natured.Nourishiing yin to clear away the lung-heat, promoting blood circulation.The main void dryness of the lung, dry throat of coughing, puerperal asthenia, Fu Nvgan Consumptive disease, traumatic injury, fracture.《Shaanxi Chinese herbal medicine》Carry：" curing rheumatism, clearing heat-fire, pain easing and hemostasis, regulating menstruation and activating blood, enriching yin qi-restoratives. Treating rheumatic arthritis, lumbocrural pain, traumatic injury, internal lesion caused by overexertion,
Irregular menstruation, hectic fever due to yin labor heat.”
Climbing fig：It is sour, cool in nature.Dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, removing toxicity for detumescence.Main arthralgia pain due to rheumatism, sciatica, rush down dysentery, urine Leaching, oedema, malaria, amenorrhoea, postpartum blood stasis abdominal pain, abscess of throat, orchitis, dermatitis rhus, pain pyogenic infections from tumour or sore, traumatic injury.《Shanghai is normal Use Chinese herbal medicine》Carry：" wind-damp dispelling, clearing and activating the channels and collaterals, clearing heat for detumescence, diuresis, hemostasis.Control rheumatalgia, brothers' articular instability.”
Glabrousleaf pittosporum root：It is sweet in flavor, bitter, pungent, it is cool in nature.Tonifying lung kidney, wind-damp dispelling are promoting blood circulation and removing obstruction in channels.Control consumptive disease to breath with cough, premature ejaculation of passing out semen, have a sleepless night, head It is dizzy, high blood pressure, rheumatic arthralgia, infantile paralysis.Guangzhou army《Common Chinese herbal medicine handbook》Carry：" promoting blood circulation and removing obstruction in channels, spasmolysis Analgesic.Treating rheumatic arthritis, sciatica, injury and bone fracture, sequelae of infantile paralysis, postpartum paralysis, heart and stomach pain, tooth Bitterly.”
Phoenix tree leaf：Bitter, it is cold in nature；Return lung, Liver Channel.Dispelling wind and eliminating dampness, removing toxicity for detumescence, blood pressure lowering.Main arthralgia pain due to rheumatism, traumatic injury, Ulcerative carbuncle pyogenic infections, hemorrhoid, infantile malnutrition, rush down dysentery, high blood pressure.
Shuo Di：It is sweet in flavor, sour, it is warm-natured.Return the liver channel of foot-Jueyin.Dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis.Treatment of rheumatalgia pain, nephritic dropsy, Beriberi edema, dysentery, jaundice, chronic bronchitis, rubella itch, erysipelas, sore swells, traumatic injury, fracture.《Changsha medicine solution》Carry： " promoting circulation of blood promoting menstruation, dispersing blood stasis are coagulated.Oedema is treated, by arthritis with fixed pain caused by dampness, lower disease block, broken stasis of blood blood, washes urticaria wind scabies, applies pin swelling and pain in knee.”
Chinese sumac root：It is sour, salty, it is cool in nature.Returns spleen, kidney channel.Go wind, dampness elimination, detumescence, softening hard masses.Cure cold fever, cough, diarrhea, Oedema, rheumatism numbness cancer, bruise wound is swollen, and acute mastitis, tinea sore, disappear wine poison.Guangzhou army《Common Chinese herbal medicine handbook》Carry：" cool blood fall fire, Stasis eliminatings life is new, controls measles, cold, fever, cough band blood；Injury and bone fracture.”
Variegated leaf is blue：It is sweet in flavor, pungent, it is mild-natured.Moisten the lung and relieve the cough, tonify Qi of the kidney, the promoting flow of qi and blood circulation, subdhing swelling and detoxicating.Main pulmonary tuberculosis cough, tracheae Inflammation, dizzy weak, neurasthenia, impotence, traumatic injury, arthralgia, abscess of throat, acute mastitis, boil, scrofula, venomous snake bite. 《Often use Chinese herbal medicine in Tibet》Carry：" softening and resolving hard mass.Control scrofula.”
Holly leaf：Bitter, it is cool in nature；Return liver and kidney channel.Clearing heat and nourishing yin, soothing the liver, kidney-nourishing.Spit blood for tuberculosis, osteopyrexia and fever is dizzy It is dizzy, hypertension.《Middle traditional Chinese medicines plant will》Carry：" branches and leaves：Decocted with also sugar, jujube or smoked jujube are same, filling liver kidney, is good for waist and knee.”
Old rice：It is sweet in flavor, light, it is mild-natured；Return stomach, large intestine, the spleen channel.Adjust and neutralize stomach, excreting dampness antidiarrheal, relieving restlessness.
Main weakness of the spleen and the stomach, deficiency of food, diarrhea gastric disorder causing nausea, dysentery with vomiting, polydipsia.《Dietetic materia medica》Carry：" cook a meal and eat it as cooked rice, stop dysentery, Tonifying middle-Jiao and Qi, hard muscles and bones, promoting blood circulation, Qi Yang roads.And the swollen malignant sore of poison, old person, which steams, long makees meal, and jealous woman is sealed on swollen.Sudden precordial pain, grinds and takes Juice takes it.Beiren cook a meal in urn, water logging order acid, eat it, warm up the vital organs of the human body gas.”
Hawthorn：It is sour, sweet, slightly warm in nature；Returns spleen, stomach, liver, lung channel.Digestion gathered food, changes the stagnant stasis of blood.Main eating accumulation, abdominal distention, lets out Rush down dysentery disease, dysmenorrhea due to blood stasis, amenorrhoea, postpartum abdominal pain, lochiorrhagia.Ning Yuan《Food mirror book on Chinese herbal medicine》Carry：" change clot, air parcel, promoting blood circulation." existing Confirmed for medical research, hawthorn can distend the blood vessels, and coronary flow increase, blood pressure declines.
Farges fir cone：Sweet in flavor, puckery, micro-pungent, it is mild-natured.It is calming the liver to stop the wind, regulating menstruation and activating blood, stop-band.Main hypertension pain, headache, dizziness, It is confused and worried, irregular menstruation, uterine bleeding, with.《Shaanxi Chinese herbal medicine》Carry：" calming the liver to stop the wind, regulating menstruation and activating blood, hemostasis, tranquilizing the mind. Vascular hypertension is controlled, is had a headache, dizzy, confused and worried, irregular menstruation, uterine bleeding, leukorrhea.”
Compared with prior art, the present invention have the advantages that：
The traditional Chinese medical science and western medicine therapy are combined by Chinese and western medicinal composition of the present invention, and all medicine phases are closed with promoting blood circulation, the powdered medicine ' Tongluosan ' stasis of blood, mended Kidney QI invigorating, tranquilizing the mind, calming the liver to stop the wind, blood pressure lowering, hard muscles and bones, promoting blood circulation, Qi Yang roads and other effects, can be in treatment thrombotic brain Play the role of conserving the internal organs such as the heart, the liver,spleen,kidney of Cerebral thrombosis patient while infarct, for treating thrombotic brain Infarct is curative for effect, quick, and in the side of choosing, the present invention has certain novelty, has certain social economic value.
Embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of Chinese and western medicinal composition active ingredient of the present invention forms and weight is：Water chestnut 58g, seven 51g of bamboo root, climbing fig 51g, mountain Ramose root 48g, phoenix tree leaf 45g, Shuo Di 38g, Chinese sumac root 38g, variegated leaf orchid 36g, holly leaf 30g, old rice 20g, hawthorn 20g, Farges fir cone 16g, cinnarizine 0.45g, ligustrazine 0.9g.
The preparation method of Chinese and western medicinal composition of the present invention, comprises the following steps that：
(1) water chestnut is removed into tender shoots, ground, leaching white juice, is precipitated, dry, obtains 180 purposes
Fine powder, it is spare；
(2) bamboo root seven, glabrousleaf pittosporum root, phoenix tree leaf, Chinese sumac root, old rice, hawthorn and farges fir cone are put into container, add 10 times Measure distilled water immersion 4 it is small when after, heating boil 4 it is small when, extraction；Second add 8 times of amount distilled water heating boil 3 it is small when, carry Take；Third time add 6 times amount distilled water heating boil 2 it is small when, extraction；Merge gained extracting solution three times, filtration, it is standby to obtain filtrate With；
(3) by climbing fig He Shuo Di enter in juice extractor to squeeze the juice, filtering, deoxidation, vacuum freeze drying, obtained 160 targeted fine powders, standby With；
(4) by variegated leaf is blue and holly leaf immerse 10 times of amount volumetric concentrations, 70% alcohol solution dipping 4 it is small when, heating extraction, filtration, After standing, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 thick paste it is spare；
(5) cinnarizine is dissolved in the 117-127o boiling ethanol of 0.5 times of amount, obtains solution for standby；
(6) ligustrazine is added to 80-85 ° of hot water dissolving of 6-10 times of weight, obtains solution for standby；
(5) fine powder of above-mentioned gained, filtrate, thick paste and solution are mixed, the distilled water of 10 times of amounts is added, under 121 DEG C of hot pressing Sterilizing 30 minutes, is made the tablet of 0.4g/ pieces, packs according to a conventional method, is the treatment Cerebral thrombosis Chinese and western medicinal composition.
Usage and dosage：Oral, 3 times a day, 2 tablets once（Every 0.4g）, warm water delivery service after meal, 7 days as one therapeutic course, 4 It can fully recover to 8 courses for the treatment of, serious patient increases the amount of discretion, this medicine allergies person, depression medical history person, encephalic are lived Dynamic property bleeder, hemorrhagic disease person, hemorrhagic tendency person and pregnancy women disabling.
Embodiment 2
The raw material of Chinese and western medicinal composition active ingredient of the present invention forms and weight is：Water chestnut 57g, seven 50g of bamboo root, climbing fig 50g, mountain Ramose root 47g, phoenix tree leaf 44g, Shuo Di 37g, Chinese sumac root 37g, variegated leaf orchid 35g, holly leaf 29g, old rice 19g, hawthorn 19g, Farges fir cone 16g, cinnarizine 0.4g, ligustrazine 0.8g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Embodiment 3
The raw material of Chinese and western medicinal composition active ingredient of the present invention forms and weight is：Water chestnut 54g, seven 47g of bamboo root,
Climbing fig 47g, glabrousleaf pittosporum root 44g, phoenix tree leaf 41g, capsule Di 34g, Chinese sumac root 34g, variegated leaf orchid 32g, holly leaf 27g, Chen Cang Rice 18g, hawthorn 18g, farges fir cone 14g, cinnarizine 0.3g, ligustrazine 0.7g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Embodiment 4
The raw material of Chinese and western medicinal composition active ingredient of the present invention forms and weight is：Water chestnut 51g, seven 44g of bamboo root, climbing fig 44g, mountain Ramose root 41g, phoenix tree leaf 38g, Shuo Di 31g, Chinese sumac root 31g, variegated leaf orchid 29g, holly leaf 25g, old rice 17g, hawthorn 17g, Farges fir cone 13g, cinnarizine 0.2g, ligustrazine 0.6g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Experimental section（Animal acute toxicity test）：
1st, experiment material：Experimental animal is healthy mice, half male and half female, 24 ± 1g of weight, every group of 20 mouse.Experimental drug selects With Chinese and western medicinal composition of the present invention, aspirin.Experiment material selects ALT assay kits.
2nd, method：
Experimental group：Take Chinese and western medicinal composition 1 of the present invention to be dissolved in 10ml water, gavage is carried out to mouse, gavage volume is 10ml/kg, once in the morning and once at night, totally 4 days.
Control group：Taking aspirin 1 to be dissolved in 10ml water, gavage is carried out to mouse, gavage volume is 10ml/kg, Once in the morning and once at night, totally 4 days.
Blank group：Same amount of physiological saline is taken, once in the morning and once at night, totally 4 days.
3rd, detection and testing result：
(1), liver lesion detection：After 4 days, mouse orbit takes blood, separates serum.Measure serum ALT activities.
As a result：Aspirin control group mice serum ALT activities are apparently higher than test group.
Discuss：According to above experimental result, compared with conventional medicine aspirin, the Chinese and Western medicine combination in the application Thing can be reduced greatly to hepar damnification degree.
(2), kidney injury detects：Light microscopy checking.
As a result：The visible glomerular capillary basement membrane diffusivity of control group nephridial tissue light microscopy checking thickens, and kidney is small
Ball increases, matrix showed increased.Experimental group and naive mice glomerulus and tubulo-interstital have no obvious pathological change.
Discuss：According to above experimental result, compared with conventional medicine aspirin, the Chinese and Western medicine combination in the application Thing can greatly reduce the degree of injury to kidney.
Clinical data：
1st, case selection：
The Patients with 300 Cases clinical observation of Cerebral thrombosis is selected, patient is randomly divided into treatment group and control group, treatment group 150 Example, wherein male 75, women 75, age 45-77 Sui, average age 63.1 years old, the course of disease -2 years 1 week；Control group 150, Wherein male 75, women 75, age 45-77 Sui, average age 63.7 years old, the course of disease -2 years 1 week；The course of disease of two groups of cases, Degrees of symptoms is basically identical, and no significant difference, is comparable.
2nd, medicament selection：
Treatment group patient takes Chinese and western medicinal composition of the present invention, takes orally, 3 times a day, 2 tablets once（Every 0.4g）, after meal temperature open Water delivery service, 7 days as one therapeutic course, 4 to 8 courses for the treatment of can fully recover, and serious patient increases the amount of discretion, this medicine allergies Person, depression medical history person, encephalic active hemorrhage person, hemorrhagic disease person, hemorrhagic tendency person and pregnancy women disabling.
Control group Aspirin, by specification are used, and serious patient increases the amount of discretion.
3rd, efficacy determination：
（1）Cure：It is slow in reacting, feel excessively, sensory disturbance, high fever, hypertension, dysphagia, the symptom such as powerless disappear, body Body recovers normal.
（2）Effectively：Above-mentioned symptom has been alleviated.
（3）It is invalid：Illness is unchanged.
4th, result：
The above results show that treatment group's cure rate and total effective rate are apparently higher than control group.
Model case is illustrated：
1st, Mr. Wang, male, 72 years old, is engaged in agriculture.Patient has hypertension history more than 4 years, non-rule medication treatment, and control effect is poor.5 years Spoken with a lisp after preceding activity without happening suddenly under obvious inducement, difficulty in walking is to our hospital, is diagnosed as thrombotic cerebral infarction on inspection Extremely.Give and take Chinese and western medicinal composition of the present invention 15 days, above-mentioned symptom improves；Continue to take Chinese and western medicinal composition 30 of the present invention My god, physical recovery is normal, and follow-up is not recurred, thoroughly cures.
2nd, Liu, female, 69 years old, retired worker.There are dizzy, headache syndromes before 5 years without obvious inducement in patient, dashed forward before 1 year So there is the symptom such as glossolalia, dysphagia, slow in reacting, it is to our hospital, Cerebral thrombosis is diagnosed as on inspection.Give Give and take Chinese and western medicinal composition of the present invention 15 days, above-mentioned symptom improves；Continue to take Chinese and western medicinal composition of the present invention 25 days, it is above-mentioned Symptom disappears, and physical recovery is normal, and follow-up is not recurred, thoroughly cures.
3rd, it is virgin certain, man, 64 years old, is engaged in agriculture.There is dizziness, headache, the symptom such as blurring of vision before 5 years without obvious inducement in patient, and 2 There is glossolalia, gatism after rising in Nian Qianchen, then to our hospital, is diagnosed as Cerebral thrombosis on inspection.Give Take Chinese and western medicinal composition of the present invention 15 days, above-mentioned symptom improves；Continue to take Chinese and western medicinal composition of the present invention 28 days, above-mentioned disease Shape disappears, and follow-up is not recurred, thoroughly cures.
4th, Xu certain, female, 58 years old, retired professor.Patient with diabetes, hypertension happen suddenly before more than 2 years, 1 year slurred speech, The symptoms such as difficulty in walking, dizziness, it is to our hospital, Cerebral thrombosis is diagnosed as on inspection.Give and take Chinese and Western medicine of the present invention Composition 18 days, above-mentioned symptom improve；Continue to take Chinese and western medicinal composition of the present invention 35 days, above-mentioned symptom all disappears, body Recovery from illness, follow-up are not recurred, are thoroughly cured.
5th, it is pungent certain, man, 52 years old, police.Patient has hypertension history, and the glossolalia that happened suddenly in the street before 4 years, walking are tired The symptom such as difficult, powerless, dysphagia, it is to our hospital, Cerebral thrombosis is diagnosed as on inspection.Give and take Chinese and Western of the present invention Drug composition 15 days, above-mentioned symptom improve；Continue to take Chinese and western medicinal composition of the present invention 25 days, above-mentioned symptom all disappears, body Body is fully recovered, and follow-up is not recurred, is thoroughly cured.
6th, Zhang, female, 49 years old, is engaged in agriculture.Patient before 3 years the morning go out under the street is without obvious inducement burst speak with a lisp, The symptoms such as left myasthenia of limbs, difficulty in walking, it is to our hospital, thrombotic cerebral infarction is diagnosed as on inspection
Extremely.Give and take Chinese and western medicinal composition of the present invention 45 days, above-mentioned symptom disappears, and physical recovery is normal, and follow-up is not recurred, thorough Bottom cures.

Claims (5)

  1. A kind of 1. Chinese and western medicinal composition for treating Cerebral thrombosis, it is characterised in that：It is effective that the Chinese and western medicinal composition is made Component includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are formulated by the raw material of following weight number：Water chestnut 48-60g, Seven 41-53g of bamboo root, climbing fig 41-53g, glabrousleaf pittosporum root 38-50g, phoenix tree leaf 35-47g, Shuo Di 28-40g, Chinese sumac root 28-40g, Variegated leaf orchid 26-38g, holly leaf 23-31g, old rice 16-21g, hawthorn 16-21g, farges fir cone 12-17g；The western medicine component by The raw material of following weight number is formulated：Cinnarizine 0.1-0.5g, ligustrazine 0.5-1g.
  2. A kind of 2. Chinese and western medicinal composition for treating Cerebral thrombosis according to claim 1, it is characterised in that：Institute is made Stating Chinese and western medicinal composition active ingredient includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are matched somebody with somebody by the raw material of following weight number System forms：Water chestnut 57g, seven 50g of bamboo root, climbing fig 50g, glabrousleaf pittosporum root 47g, phoenix tree leaf 44g, Shuo Di 37g, Chinese sumac root 37g, variegated leaf Blue 35g, holly leaf 29g, old rice 19g, hawthorn 19g, farges fir cone 16g；The western medicine component is matched somebody with somebody by the raw material of following weight number System forms：Cinnarizine 0.4g, ligustrazine 0.8g.
  3. A kind of 3. Chinese and western medicinal composition for treating Cerebral thrombosis according to claim 1, it is characterised in that：Institute is made Stating Chinese and western medicinal composition active ingredient includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are matched somebody with somebody by the raw material of following weight number System forms：Water chestnut 54g, seven 47g of bamboo root, climbing fig 47g, glabrousleaf pittosporum root 44g, phoenix tree leaf 41g, Shuo Di 34g, Chinese sumac root 34g, variegated leaf Blue 32g, holly leaf 27g, old rice 18g, hawthorn 18g, farges fir cone 14g；The western medicine component is matched somebody with somebody by the raw material of following weight number System forms：Cinnarizine 0.3g, ligustrazine 0.7g.
  4. A kind of 4. Chinese and western medicinal composition for treating Cerebral thrombosis according to claim 1, it is characterised in that：Institute is made Stating Chinese and western medicinal composition active ingredient includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are matched somebody with somebody by the raw material of following weight number System forms：Water chestnut 51g, seven 44g of bamboo root, climbing fig 44g, glabrousleaf pittosporum root 41g, phoenix tree leaf 38g, Shuo Di 31g, Chinese sumac root 31g, variegated leaf Blue 29g, holly leaf 25g, old rice 17g, hawthorn 17g, farges fir cone 13g；The western medicine component is matched somebody with somebody by the raw material of following weight number System forms：Cinnarizine 0.2g, ligustrazine 0.6g.
  5. 5. a kind of preparation method for the Chinese and western medicinal composition that Cerebral thrombosis is treated such as claim 1-4 any one of them, It is characterized in that：Comprise the following steps：
    (1) water chestnut is removed into tender shoots, ground, leaching white juice, is precipitated, dry, obtains 180 targeted fine powders, spare；
    (2) bamboo root seven, glabrousleaf pittosporum root, phoenix tree leaf, Chinese sumac root, old rice, hawthorn and farges fir cone are put into container, add 10 times Measure distilled water immersion 4 it is small when after, heating boil 4 it is small when, extraction；Second add 8 times of amount distilled water heating boil 3 it is small when, carry Take；Third time add 6 times amount distilled water heating boil 2 it is small when, extraction；Merge gained extracting solution three times, filtration, it is standby to obtain filtrate With；
    (3) by climbing fig He Shuo Di enter in juice extractor to squeeze the juice, filtering, deoxidation, vacuum freeze drying, obtained 160 targeted fine powders, standby With；
    (4) by variegated leaf is blue and holly leaf immerse 10 times of amount volumetric concentrations, 70% alcohol solution dipping 4 it is small when, heating extraction, filtration, After standing, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 thick paste it is spare；
    (5) cinnarizine is dissolved in the 117-127o boiling ethanol of 0.5 times of amount, obtains solution for standby；
    (6) ligustrazine is added to 80-85 ° of hot water dissolving of 6-10 times of weight, obtains solution for standby；
    (5) fine powder of above-mentioned gained, filtrate, thick paste and solution are mixed, the distilled water of 10 times of amounts is added, under 121 DEG C of hot pressing Sterilizing 30 minutes, is made the tablet of 0.4g/ pieces, packs according to a conventional method, is the treatment Cerebral thrombosis Chinese and western medicinal composition.
CN201710280492.8A 2017-04-26 2017-04-26 A kind of Chinese and western medicinal composition and preparation method for treating Cerebral thrombosis Withdrawn CN107913372A (en)

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