CN114762501A - Nano chitosan zinc and preparation method and application thereof - Google Patents
Nano chitosan zinc and preparation method and application thereof Download PDFInfo
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- CN114762501A CN114762501A CN202110048040.3A CN202110048040A CN114762501A CN 114762501 A CN114762501 A CN 114762501A CN 202110048040 A CN202110048040 A CN 202110048040A CN 114762501 A CN114762501 A CN 114762501A
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- zinc
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 61
- 239000011701 zinc Substances 0.000 title claims abstract description 61
- 229920001661 Chitosan Polymers 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title abstract description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000000463 material Substances 0.000 claims abstract description 48
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 43
- 229920002101 Chitin Polymers 0.000 claims abstract description 41
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 38
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 38
- 239000011787 zinc oxide Substances 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 15
- 239000000344 soap Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- -1 body wash Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 3
- 239000008269 hand cream Substances 0.000 claims description 3
- 239000010985 leather Substances 0.000 claims description 3
- 239000002453 shampoo Substances 0.000 claims description 3
- 239000000077 insect repellent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 31
- 241000700605 Viruses Species 0.000 abstract description 19
- 241000894006 Bacteria Species 0.000 abstract description 18
- 239000003642 reactive oxygen metabolite Substances 0.000 abstract description 12
- 230000002401 inhibitory effect Effects 0.000 abstract description 11
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 241000711573 Coronaviridae Species 0.000 abstract description 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 241001493065 dsRNA viruses Species 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 238000005286 illumination Methods 0.000 abstract description 2
- 206010022000 influenza Diseases 0.000 abstract description 2
- 230000010076 replication Effects 0.000 abstract description 2
- 230000001580 bacterial effect Effects 0.000 description 15
- 239000003599 detergent Substances 0.000 description 14
- 230000009471 action Effects 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 230000032683 aging Effects 0.000 description 10
- 239000003256 environmental substance Substances 0.000 description 10
- 239000008233 hard water Substances 0.000 description 10
- 230000007246 mechanism Effects 0.000 description 10
- 241000304886 Bacilli Species 0.000 description 9
- 244000309711 non-enveloped viruses Species 0.000 description 8
- 238000004925 denaturation Methods 0.000 description 7
- 230000036425 denaturation Effects 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 239000002105 nanoparticle Substances 0.000 description 5
- 239000005416 organic matter Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000238424 Crustacea Species 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910001385 heavy metal Inorganic materials 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000013066 combination product Substances 0.000 description 2
- 229940127555 combination product Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229940035535 iodophors Drugs 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002078 nanoshell Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000011941 photocatalyst Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a nano zinc crust and a preparation method and application thereof, wherein the nano zinc crust is prepared by the following raw materials: zinc oxide, protein and chitin. The invention has the beneficial effects that: the nano-scale zinc chitin can continuously and effectively produce Reactive Oxygen Species (ROS) to inhibit the growth of pathogenic bacteria, mold and viruses, and zinc ions in the nano-scale zinc chitin material can be partially dissociated to inhibit the replication of RNA viruses in the state of aqueous solution, so that the nano-scale zinc chitin has the effects of inhibiting influenza, SARS and new coronavirus; the nano chitin zinc is combined with the nano zinc on the chitin, so that the nano chitin zinc can release Reactive Oxygen Species (ROS) under the condition of no illumination, namely, the nano chitin zinc can continuously play a role in sterilizing 24 hours all day long, and can also inhibit the functions of viruses and bacteria for a long time even in dark corners; the nano chitin zinc organically combines natural antibacterial components, is beneficial to body health after long-term use, and the components cannot be accumulated in the body and can be naturally metabolized and utilized in the body.
Description
Technical Field
The invention belongs to the technical field of antibacterial materials, and particularly relates to nano chitosan, and a preparation method and application thereof.
Background
With the use of antibiotics, bactericides and other chemical drugs, more and more microorganisms generate drug resistance to the drugs, and thus, global microbial disaster events caused by the drug resistance frequently occur. In order to prevent the occurrence of microbial events, it is necessary to research a novel antibacterial material.
Chitin is generally referred to as chitin, a polysaccharide substance extracted from the shell of marine crustaceans. Chitin is a polycation electrolyte with positive charges, has high protein adsorption capacity, and can effectively resist invasion of various viruses, bacteria, parasites and even cancers; in addition, chitin can repair cells, induce cells and activate cells, and can repair cell membranes to achieve the purpose of activating cells; chitin existing in nature has a strong structure due to strong hydrogen bonding among macromolecules, is generally not melted, is not dissolved in water, acid and alkali and common organic solvents, and has limited application due to very stable chemical properties.
Disclosure of Invention
The invention aims to provide nano chitosan capable of continuously and effectively producing Reactive Oxygen Species (ROS) and having a lasting and safe disinfection and sterilization effect, and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the first aspect of the present invention provides a nano chitosan zinc, which is prepared from the following raw materials in parts by weight: 8-12 parts of zinc oxide, 0.8-1.2 parts of protein and 1.8-2.2 parts of chitin.
The nano chitosan zinc is prepared from the following raw materials in parts by weight as a preferred embodiment: 9-11 parts of zinc oxide, 0.9-1.1 parts of protein and 1.9-2.1 parts of chitin.
The nano crustacean zinc is prepared from the following raw materials in parts by weight as a preferred embodiment: 10 parts of zinc oxide, 1 part of protein and 2 parts of chitin.
The zinc oxide is zinc oxide, is white powder with stable properties, is insoluble in water, has the effects of adsorbing grease and water, killing bacteria and fungi, and can effectively inhibit the damage of staphylococcus aureus and candida to the skin.
In a second aspect of the present application, a method for preparing nano chitosan is provided, which comprises the following steps:
(1) mixing the above materials, and stirring to obtain mixture;
(2) performing microwave treatment on the mixture obtained in the step (1) to obtain the nano-shell zinc.
Preferably, under the microwave treatment condition, the protein is used as a medium, the protein is simultaneously combined with the zinc oxide and the chitin, and the combined product of the protein and the zinc oxide and the combined product of the protein and the chitin are combined to obtain the nano chitin zinc.
The combination product of protein and zinc oxide is compound a, the structural formula of which is:
the combination product of the protein and the chitin is a compound b, and the structural formula of the compound b is as follows:
as a preferred embodiment, in the step (2), the microwave frequency of the microwave treatment is 480-520W, and the time is 2-5 min.
In a third aspect of the present invention, an application of nano-sized chitosan in disinfection and antibiosis is provided.
The above application, as a preferred embodiment, is an application of the nano carapace zinc in soap, hand sanitizer, hair shampoo, body wash, hand cream, antibacterial paper bag, antibacterial mask pad, antibacterial toilet paper, antibacterial mosquito-proof liquid, antibacterial mosquito-proof patch, antibacterial leather care agent, antibacterial adhesive film, sanitary towel, facial mask or food additive.
Compared with the prior art, the invention has the beneficial effects that:
1. the nano crust zinc material can continuously and effectively produce Reactive Oxygen Species (ROS) to inhibit the growth of pathogenic bacteria, mould and viruses, and zinc ions in the nano crust zinc material can be partially dissociated to inhibit the replication of RNA viruses in an aqueous solution state, so that the nano crust zinc material has good effects of inhibiting influenza, SARS and new coronavirus.
2. The nano chitin zinc material of the invention combines nano zinc on chitin, and can release Reactive Oxygen Species (ROS) under the condition of no illumination, namely, the nano chitin zinc material can continuously play a role in sterilizing 24 hours all day long, and can achieve the effect of inhibiting viruses and bacteria for a long time even in dark corners.
3. The nano crust zinc material of the invention organically combines natural antibacterial components, is beneficial to body health after long-term use, and the components can not be accumulated in the body and can be naturally metabolized and utilized in the body.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The nano carapace zinc material can be applied to disinfection and antibiosis, such as soap, hand sanitizer, shampoo, bath lotion, hand cream, antibacterial paper bags, antibacterial mask pads, antibacterial toilet paper, antibacterial mosquito-proof liquid, antibacterial mosquito-proof patches, antibacterial leather maintenance agents, antibacterial sticking films, sanitary towels, facial masks or food additives.
The antibacterial performance of the nano crust zinc material of the invention is compared with the antibacterial performance of the commonly used antibacterial products on the market, as follows:
1. the product of the invention is as follows:
the action mechanism is as follows: the cell walls of bacteria and mould are penetrated and destroyed, so that the bacteria die; releasing ROS reactive oxygen species to destroy viral and bacterial surface proteins; inhibiting viral RDRP, replicating viral RNA;
and (3) aging inhibition: long-acting;
the advantages are that: broad-spectrum antibacterial, food-grade, nontoxic and safe;
the antibacterial effect is as follows: effective against bacteria, bacilli, mold, enveloped virus, and non-enveloped virus;
environmental substance influences the effect: can be used with organic substances, hard water, soap, and detergent.
2. Preservative: such as hair washing, laundry and paint products
The action mechanism is as follows: protein denaturation;
and (3) aging inhibition: long-acting;
the advantages are that: can resist various microorganisms;
the disadvantages are that: high aquatic toxicity, strong toxicity to aquatic organisms; can cause anaphylactic reaction to human body; high concentrations can poison mucosal cells;
the antibacterial effect is as follows: effective against bacteria, bacilli, mold, enveloped virus, and non-enveloped virus;
environmental substances influence the effect: can be used with hard water, soap, and detergent, and has reduced effect when coexisting with organic substances.
3. Alcohols: such as alcohol, isopropyl alcohol
The action mechanism is as follows: protein and lipid denaturation;
and (3) inhibiting aging: short-term effect;
the advantages are that: quick acting and no residue;
the disadvantages are as follows: the fuel is combustible and has short action time;
the antibacterial effect is as follows: effective against bacteria, bacillus, mold, and enveloped virus; the effect on different strains without the coat virus is different;
environmental substances influence the effect: the effect is reduced when the composition is used together with hard water, soap, detergent and organic matters.
4. Nano silver
The action mechanism is as follows: after silver ions enter a cell membrane, the synthesis of cell walls is disturbed randomly, and the cross-linking effect among polysaccharide chains is inhibited;
and (3) inhibiting aging: long-acting;
the advantages are that: can resist various microorganisms;
the disadvantages are as follows: easily run into the maternal placenta and directly affect the fetus; the medicine has toxicity on lung cells, nerve cells and skin cells, and can permeate into the brain to flow through blood circulation and reach other body tissues to generate accumulated toxicity;
the antibacterial effect is as follows: effective against bacteria, bacilli, mold, enveloped virus, and non-enveloped virus;
environmental substance influences the effect: can be used with hard water, soap, detergent, and organic matter, and has reduced effect.
5. Aldehydes: such as formaldehyde, glutaraldehyde
The action mechanism is as follows: protein denaturation, nucleic acid alkylation;
and (3) aging inhibition: short-term effect;
the advantages are that: can resist various microorganisms;
the disadvantages are as follows: toxic, carcinogenic;
the antibacterial effect is as follows: effective against bacteria, bacilli, mold, enveloped virus, and non-enveloped virus;
environmental substances influence the effect: the effect of the detergent is reduced when the detergent is used with organic matters, hard water, soap and detergents. 6. 6, nano photocatalyst: such as titanium dioxide, zinc oxide
The action mechanism is as follows: after absorbing light energy, nearby oxygen and water are triggered to be converted into extremely active superoxide ions and hydroxyl radicals, and organic substances (viruses, bacteria, odor and oil stains) in the environment are decomposed into carbon dioxide and water which are harmless to the environment;
and (3) inhibiting aging: long-acting;
the advantages are that: is non-toxic and safe;
the disadvantages are as follows: the antibacterial property is achieved only by ultraviolet excitation;
the antibacterial effect is as follows: effective against bacteria, bacilli, mold, and non-enveloped viruses;
environmental substance influences the effect: can be used with organic matter, hard water, soap, and detergent.
7. Peroxide disinfectant: such as hydrogen peroxide, glacial acetic acid, and Weike
The action mechanism is as follows: protein and lipid denaturation;
and (3) inhibiting aging: short-term effect;
the advantages are that: can resist various microorganisms;
the disadvantages are that: the product has unstable property, transportation and storage of explosion risk, is easy to decompose and corrosive, has irritation or toxicity before decomposition, and has bleaching or corrosive effect on articles;
the antibacterial effect is as follows: effective against bacteria, bacilli, enveloped viruses, and non-enveloped viruses; the effects on different varieties of moulds are different;
environmental substances influence the effect: the effect of the detergent is reduced when the detergent is used with organic matters, hard water, soap and detergents.
8. Quaternary ammonium salt disinfectant: such as BKC, Quatemary
The action mechanism is as follows: protein denaturation, binding to cell membrane phospholipids;
and (3) inhibiting aging: short-term effect;
the advantages are that: the toxicity is low;
the disadvantages are as follows: effective only against bacteria and non-enveloped viruses;
the antibacterial effect is as follows: effective against bacteria, bacilli, and non-coat viruses; is not effective on mould and enveloped virus;
environmental substance influences the effect: it is ineffective when used with organic matter, hard water, soap and detergent.
9. Chlorine-containing disinfectants: such as bleaching water
The action mechanism is as follows: protein denaturation;
and (3) inhibiting aging: short-term effect;
the advantages are that: can resist various microorganisms;
the disadvantages are that: sunlight failure, corrosion to metal, irritation to mucous membranes and tissues;
the antibacterial effect is as follows: effective against bacteria, bacilli, enveloped viruses, non-enveloped viruses, and enveloped viruses;
environmental substance influences the effect: can be used with hard water, and can be used with organic matter, soap, and detergent.
10. Iodine-containing disinfectant: such as iodophors
The action mechanism is as follows: protein denaturation;
and (3) inhibiting aging: short-term effect;
the advantages are that: can resist various microorganisms;
the disadvantages are that: corrosive, staining clothes or applying surface stains;
the antibacterial effect is as follows: effective against bacteria, mold, and enveloped virus; ineffective against bacilli and non-coat viruses;
environmental substances influence the effect: can be used with hard water, soap, detergent, and organic matter, and can be ineffective.
In the examples of the present invention, 1 part by weight represents 1 g.
Example 1
A nano crust zinc material is prepared by the following raw materials by weight: 8 parts of zinc oxide, 0.8 part of protein and 1.8 parts of chitin.
The preparation method of the nano crust zinc material comprises the following steps:
(1) mixing the above materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) for 5min under the condition that the microwave frequency is 480w, combining zinc oxide and protein to generate a compound a, combining protein and chitin to generate a compound b, and combining the compound a and the compound b to obtain the nano crust zinc material.
Example 2
A nano crust zinc material is prepared by the following raw materials by weight: 9 parts of zinc oxide, 0.9 part of protein and 1.9 parts of chitin.
The preparation method of the nano crust zinc material comprises the following steps:
(1) mixing the above raw materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) for 3min under the condition that the microwave frequency is 490w, wherein under the microwave treatment condition, zinc oxide is combined with protein to generate a compound a, the protein is combined with chitin to generate a compound b, and the compound a is combined with the compound b to obtain the nano crust zinc material.
Example 3
A nano crust zinc material is prepared by the following raw materials by weight: 10 parts of zinc oxide, 1 part of protein and 2 parts of chitin.
The preparation method of the nano crust zinc material comprises the following steps:
(1) mixing the above raw materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) for 3min under the condition that the microwave frequency is 480w, combining zinc oxide and protein to generate a compound a, combining protein and chitin to generate a compound b, and combining the compound a and the compound b to obtain the nano crust zinc material.
Example 4
A nano crust zinc material is prepared by the following raw materials by weight: 11 parts of zinc oxide, 1.1 parts of protein and 2.1 parts of chitin.
The preparation method of the nano crust zinc material comprises the following steps:
(1) mixing the above materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) for 4min under the condition that the microwave frequency is 490w, wherein under the microwave treatment condition, zinc oxide is combined with protein to generate a compound a, the protein is combined with chitin to generate a compound b, and the compound a is combined with the compound b to obtain the nano crust zinc material.
Example 5
A nano crust zinc material is prepared by the following raw materials by weight: 12 parts of zinc oxide, 1.2 parts of protein and 2.2 parts of chitin.
The preparation method of the nano crust zinc material comprises the following steps:
(1) mixing the above materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) for 2min under the condition that the microwave frequency is 500w, combining zinc oxide and protein to generate a compound a, combining protein and chitin to generate a compound b, and combining the compound a and the compound b to obtain the nano crust zinc material.
1. The invention relates to a research on the disinfection and sterilization performance of a nano crust zinc material, which comprises the following steps:
1.1 test methods: reference ASTM E2149
1.2 test materials
1.2.1 the nano crust zinc material, zinc oxide and chitin (detection material) of the invention;
1.2.2 Standard strains:
escherichia coli (ATCC 23725), staphylococcus aureus (ATCC 25923), salmonella (ATCC 14028);
1.2.3 Medium: TSA medium.
1.3 test methods
1.3.1 preparing 3 bacterial liquids with turbidity of 0.5 of McFarland respectively from the 3 standard strains;
1.3.2 respectively taking 0.1ml of the 3 bacterial solutions, and respectively adding 9ml of physiological saline to obtain 3 bacterial solution diluents (3 bacterial solutions A);
respectively taking 0.1ml of the 3 bacterial liquids, and respectively adding 9.9ml of test materials (9 bacterial liquids B);
respectively taking 1ml of the 3 bacterial liquid A, and respectively adding 4ml of normal saline; (3 types C bacterial liquid)
Respectively taking 1ml of the 3 bacterial liquid A, and respectively adding 4ml of test materials; (9 types D bacterial suspension)
1.3.3 standing the A-D bacterial liquid for 1 hour at room temperature, respectively sucking 1ml of the A-D bacterial liquid, respectively adding the A-D bacterial liquid into culture dishes containing culture media, uniformly mixing, standing at 35 ℃ for culturing for 48 after the culture media are solidified, and calculating the number of bacterial colonies on a plate, wherein the results are shown in Table 1:
TABLE 1 antibacterial effect of nano Crustaceum Zinc Material of the present invention
As can be seen from the table 1, the nano-sized crustacean zinc material has better bacteriostatic effect on escherichia coli, staphylococcus aureus and salmonella, and the bacteriostatic performance of the nano-sized crustacean zinc material is superior to that of the zinc oxide and chitin which are stacked by single raw materials.
2. The safety research of the nano crust zinc material of the invention
2.1 the research of the heavy metal content of the nano crust zinc material of the invention, the detection unit is as follows: the test results of Jiamei test science and technology Co., Ltd are shown in Table 2:
TABLE 2 study on heavy metal content of nano zinc crust material
As can be seen from Table 2, the nano-sized Crustaceum zinc material of the present invention does not contain toxic heavy metal components, and trace amount of copper can enhance the bactericidal performance of the nano-sized Crustaceum zinc material.
2.2 the content of the nano chitin zinc material pesticide of the invention is researched, and the detection unit is as follows: the test results of the science and technology corporation, camei test, are shown in table 3:
TABLE 3 research on the content of nano Crustaceum Zinc pesticide
As can be seen from table 3, the nano zinc crust material of the present invention does not contain pesticide components, and the nano zinc crust component of the present invention is safe and does not produce side effects on the body after long-term use.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (8)
1. The nanometer chitosan zinc is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of zinc oxide, 0.8-1.2 parts of protein and 1.8-2.2 parts of chitin.
2. The nano chitosan zinc of claim 1, which is prepared from the following raw materials in parts by weight: 9-11 parts of zinc oxide, 0.9-1.1 parts of protein and 1.9-2.1 parts of chitin.
3. The nano chitosan zinc of claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of zinc oxide, 1 part of protein and 2 parts of chitin.
4. The method for preparing nano chitosan according to any of claims 1 to 3, comprising the following steps:
(1) mixing the above materials, and stirring to obtain mixture;
(2) and (2) performing microwave treatment on the mixture obtained in the step (1) to obtain the nano crust zinc material.
5. The method of claim 4, wherein in step (2), under the microwave treatment condition, the zinc oxide is combined with the protein to form a compound a, the protein is combined with the chitin to form a compound b, and the compound a is combined with the compound b to form the nano chitosan.
6. The method of claim 5, wherein in the step (2), the microwave treatment is performed at a microwave frequency of 480-520W for a period of 2-5 min.
7. The use of the nano-chitosan of claims 1-6 for disinfection and antibacterial purposes.
8. The use of claim 7, wherein said nano-carapace zinc is used in soap, hand sanitizer, hair shampoo, body wash, hand cream, antibacterial paper bag, antibacterial mask pad, antibacterial toilet paper, antibacterial mosquito repellent patch, antibacterial leather care agent, antibacterial film, sanitary napkin, face mask, or food additive.
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