CN114746151A - 作为Kv1.3钾Shaker通道阻断剂的芳基杂环化合物 - Google Patents

作为Kv1.3钾Shaker通道阻断剂的芳基杂环化合物 Download PDF

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CN114746151A
CN114746151A CN202080084663.XA CN202080084663A CN114746151A CN 114746151 A CN114746151 A CN 114746151A CN 202080084663 A CN202080084663 A CN 202080084663A CN 114746151 A CN114746151 A CN 114746151A
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mmol
optionally substituted
cycloalkyl
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F·焦尔达内托
M·O·詹森
V·乔吉尼
R·J·斯诺
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DE Shaw Research LLC
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WO2025021167A1 (zh) * 2023-07-26 2025-01-30 上海汇伦医药股份有限公司 芳基含氮杂环化合物、药物组合物和应用
WO2025077671A1 (zh) * 2023-10-09 2025-04-17 浙江海正药业股份有限公司 多取代芳基类衍生物及其制备方法和用途

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CA3214112A1 (en) * 2021-03-30 2022-10-06 Fabrizio Giordanetto Aryl heterocyclic compounds as kv1.3 potassium shaker channel blockers
CA3219345A1 (en) * 2021-05-28 2022-12-01 Fabrizio Giordanetto Spiroindolinone compounds as kv1.3 potassium shaker channel blockers
CN113637002B (zh) * 2021-08-02 2022-09-30 天津太平洋化学制药有限公司 一种尼拉帕尼的制备方法
CN113603573A (zh) * 2021-08-09 2021-11-05 苏州求索生物科技有限公司 一种3,5-二氯-2-碘苯甲醚的制备工艺
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CN114524800A (zh) * 2022-01-20 2022-05-24 上海陶术生物科技有限公司 尼拉帕尼中间体的合成方法
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WO2025077671A1 (zh) * 2023-10-09 2025-04-17 浙江海正药业股份有限公司 多取代芳基类衍生物及其制备方法和用途

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