CN114746091A - D-苯丙胺化合物、组合物、以及制备和使用它们的方法 - Google Patents

D-苯丙胺化合物、组合物、以及制备和使用它们的方法 Download PDF

Info

Publication number
CN114746091A
CN114746091A CN202080082873.5A CN202080082873A CN114746091A CN 114746091 A CN114746091 A CN 114746091A CN 202080082873 A CN202080082873 A CN 202080082873A CN 114746091 A CN114746091 A CN 114746091A
Authority
CN
China
Prior art keywords
compound
amphetamine
aryl
composition
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080082873.5A
Other languages
English (en)
Chinese (zh)
Inventor
S·冈瑟
G·池
T·米克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kfam Co ltd
Original Assignee
Kfam Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kfam Co ltd filed Critical Kfam Co ltd
Publication of CN114746091A publication Critical patent/CN114746091A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CN202080082873.5A 2018-10-29 2020-02-21 D-苯丙胺化合物、组合物、以及制备和使用它们的方法 Pending CN114746091A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862752324P 2018-10-29 2018-10-29
US201962800494P 2019-02-02 2019-02-02
US16/667,804 US11136295B2 (en) 2018-10-29 2019-10-29 D-amphetamine compounds, compositions, and processes for making and using the same
US16/667,804 2019-10-29
PCT/US2020/019140 WO2021086426A1 (en) 2018-10-29 2020-02-21 D-amphetamine compounds, compositions, and processes for making and using the same

Publications (1)

Publication Number Publication Date
CN114746091A true CN114746091A (zh) 2022-07-12

Family

ID=70328134

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080082873.5A Pending CN114746091A (zh) 2018-10-29 2020-02-21 D-苯丙胺化合物、组合物、以及制备和使用它们的方法
CN202080082883.9A Pending CN114746092A (zh) 2018-10-29 2020-02-21 D-苯丙胺化合物、组合物、以及制备和使用它们的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080082883.9A Pending CN114746092A (zh) 2018-10-29 2020-02-21 D-苯丙胺化合物、组合物、以及制备和使用它们的方法

Country Status (13)

Country Link
US (4) US11174229B2 (https=)
EP (2) EP4051268A4 (https=)
JP (5) JP7653429B2 (https=)
KR (3) KR20220088727A (https=)
CN (2) CN114746091A (https=)
AU (2) AU2020372736A1 (https=)
BR (2) BR112022008208A2 (https=)
CA (2) CA3158405A1 (https=)
IL (2) IL292496A (https=)
MX (2) MX2022005013A (https=)
PH (2) PH12022551047A1 (https=)
WO (2) WO2021086426A1 (https=)
ZA (2) ZA202204678B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114746092A (zh) * 2018-10-29 2022-07-12 肯法姆股份有限公司 D-苯丙胺化合物、组合物、以及制备和使用它们的方法
CN120131637A (zh) * 2025-05-08 2025-06-13 中国人民解放军海军军医大学 左乙拉西坦在制备抗疲劳的药物中的应用

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001488A1 (en) * 1987-08-07 1989-02-23 The Upjohn Company Renin inhibiting peptides with nonpeptide linkages
CN1589262A (zh) * 2000-11-21 2005-03-02 里奥制药有限公司 氰基胍前药
US20090186828A1 (en) * 2002-02-22 2009-07-23 Shire Llc Abuse-resistant amphetamine prodrugs
US20100303903A1 (en) * 2009-05-26 2010-12-02 Shire Llc Methods of enhancing selective serotonin reuptake inhibitor effects in mammals
WO2014002039A1 (en) * 2012-06-27 2014-01-03 Shire Ag Amphetamine prodrugs
WO2014055938A1 (en) * 2012-10-04 2014-04-10 Inhibikase Therapeutics, Inc. Novel compounds, their preparation and their uses
CN104812388A (zh) * 2012-10-05 2015-07-29 斯菲拉制药私人有限公司 新型化合物、其合成及其用途
EP3219712A1 (en) * 2016-03-15 2017-09-20 Cyanagen Srl Coumarin dyes and conjugates thereof
US20190142815A1 (en) * 2011-07-28 2019-05-16 Sven Guenther Methylphenidate-Prodrugs, Processes of Making and Using the Same
CN110234636A (zh) * 2016-12-11 2019-09-13 坎普哈姆公司 包含哌醋甲酯前药的组合物，其制造和使用方法
WO2020070557A1 (en) * 2018-10-02 2020-04-09 Q Biomed Inc. Modified therapeutic agent analogs of mefenamic acid
CN114746092A (zh) * 2018-10-29 2022-07-12 肯法姆股份有限公司 D-苯丙胺化合物、组合物、以及制备和使用它们的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234012A1 (de) * 1992-10-09 1994-04-14 Basf Ag Neue Anilinderivate und diese enthaltende Pflanzenschutzmittel
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
BR102012004888A2 (pt) 2012-03-05 2013-10-22 Phartrials Pesquisas Farmaceuticas Ltda Associação de um derivado de sulfamato monossubstituído do monossacarídeo natural d-frutose (topiramato) com um anti-depressivo da classe das fenilcetonas (bupropiona) para tratamento de obesidade e das síndromes plurimetabólicas
US20200114014A1 (en) 2017-04-11 2020-04-16 John K. Thottathil Novel Alpha-Hydroxy Carboxylic Acid and Derivatives and Other GRAS-Based Amide and Imide Prodrugs of Amphetamine Compounds and Uses Thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001488A1 (en) * 1987-08-07 1989-02-23 The Upjohn Company Renin inhibiting peptides with nonpeptide linkages
CN1589262A (zh) * 2000-11-21 2005-03-02 里奥制药有限公司 氰基胍前药
US20090186828A1 (en) * 2002-02-22 2009-07-23 Shire Llc Abuse-resistant amphetamine prodrugs
US20100303903A1 (en) * 2009-05-26 2010-12-02 Shire Llc Methods of enhancing selective serotonin reuptake inhibitor effects in mammals
US20190142815A1 (en) * 2011-07-28 2019-05-16 Sven Guenther Methylphenidate-Prodrugs, Processes of Making and Using the Same
WO2014002039A1 (en) * 2012-06-27 2014-01-03 Shire Ag Amphetamine prodrugs
WO2014055938A1 (en) * 2012-10-04 2014-04-10 Inhibikase Therapeutics, Inc. Novel compounds, their preparation and their uses
CN104812388A (zh) * 2012-10-05 2015-07-29 斯菲拉制药私人有限公司 新型化合物、其合成及其用途
EP3219712A1 (en) * 2016-03-15 2017-09-20 Cyanagen Srl Coumarin dyes and conjugates thereof
CN110234636A (zh) * 2016-12-11 2019-09-13 坎普哈姆公司 包含哌醋甲酯前药的组合物，其制造和使用方法
WO2020070557A1 (en) * 2018-10-02 2020-04-09 Q Biomed Inc. Modified therapeutic agent analogs of mefenamic acid
CN114746092A (zh) * 2018-10-29 2022-07-12 肯法姆股份有限公司 D-苯丙胺化合物、组合物、以及制备和使用它们的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRAECKMAN，等: "Single-dose Pharmacokinetics of KP415, an Investigational Product Containing the Prodrug Serdexmethylphenidate (SDX), in Children and Adolescents with ADHD", AMERICAN PROFESSIONAL SOCIETY OF ADHD AND RELATED DISORDERS (APSARD), 20 January 2019 (2019-01-20) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114746092A (zh) * 2018-10-29 2022-07-12 肯法姆股份有限公司 D-苯丙胺化合物、组合物、以及制备和使用它们的方法
CN120131637A (zh) * 2025-05-08 2025-06-13 中国人民解放军海军军医大学 左乙拉西坦在制备抗疲劳的药物中的应用

Also Published As

Publication number Publication date
BR112022008208A2 (pt) 2022-07-12
US12091386B2 (en) 2024-09-17
US11174229B2 (en) 2021-11-16
NZ787388A (en) 2025-05-02
JP7653429B2 (ja) 2025-03-28
JP2023501968A (ja) 2023-01-20
JP2024091930A (ja) 2024-07-05
US20240199551A1 (en) 2024-06-20
MX2022005013A (es) 2022-08-10
CA3158404A1 (en) 2021-05-06
AU2020376735A1 (en) 2022-05-12
BR112022008216A2 (pt) 2022-07-12
KR20260025885A (ko) 2026-02-24
US20200131130A1 (en) 2020-04-30
EP4051269A4 (en) 2023-12-27
JP7830540B2 (ja) 2026-03-16
JP2025163212A (ja) 2025-10-28
EP4051268A1 (en) 2022-09-07
EP4051269A1 (en) 2022-09-07
CN114746092A (zh) 2022-07-12
NZ787387A (en) 2025-05-02
US20220064116A1 (en) 2022-03-03
CA3158405A1 (en) 2021-05-06
IL292496A (en) 2022-06-01
JP2023501967A (ja) 2023-01-20
PH12022550996A1 (en) 2023-10-02
PH12022551047A1 (en) 2023-05-03
ZA202204678B (en) 2023-01-25
ZA202204747B (en) 2023-05-31
US20200129497A1 (en) 2020-04-30
WO2021086426A1 (en) 2021-05-06
JP2025023120A (ja) 2025-02-14
MX2022005012A (es) 2022-08-08
US11136295B2 (en) 2021-10-05
IL292497A (en) 2022-06-01
AU2020372736A1 (en) 2022-05-12
EP4051268A4 (en) 2024-01-17
KR20220091508A (ko) 2022-06-30
JP7653428B2 (ja) 2025-03-28
KR20220088727A (ko) 2022-06-28
WO2021086427A1 (en) 2021-05-06

Similar Documents

Publication Publication Date Title
EP2101571B1 (en) Ornithine conjugates of amphetamine and processes for making and using the same
US11505537B2 (en) Compositions comprising methylphenidate-prodrugs, processes of making and using the same
JP2010518113A (ja) アンフェタミンおよび他の刺激薬の極性親水性プロドラッグ、およびそれらの製造方法および使用方法
JP2025163212A (ja) ｄ－アンフェタミン化合物、組成物、ならびにそれを作製および使用するためのプロセス
JP2014521641A (ja) ホモアルギニンプロドラッグおよび／またはアンフェタミンおよび他の興奮剤の抱合体、ならびに同物を作製および使用するためのプロセス
WO2018107131A1 (en) Methylphenidate-prodrugs, processes of making and using the same
HK40077785A (en) D-amphetamine compounds, compositions, and processes for making and using the same
HK40078104A (en) D-amphetamine compounds, compositions, and processes for making and using the same
BR122025010953A2 (pt) Compostos de d-anfetamina, composição que compreende os mesmos, kit que compreende a dita composição e uso terapêutico dos ditos compostos

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40077785

Country of ref document: HK

CB02 Change of applicant information
CB02 Change of applicant information

Country or region after: U.S.A.

Address after: Florida, USA

Applicant after: Zefra Treatment Co.

Address before: Florida, USA

Applicant before: Kfam Co.,Ltd.

Country or region before: U.S.A.