MX2022005013A - Compuestos, composiciones de d-anfetamina, y procedimientos para fabricar y utilizar los mismos. - Google Patents
Compuestos, composiciones de d-anfetamina, y procedimientos para fabricar y utilizar los mismos.Info
- Publication number
- MX2022005013A MX2022005013A MX2022005013A MX2022005013A MX2022005013A MX 2022005013 A MX2022005013 A MX 2022005013A MX 2022005013 A MX2022005013 A MX 2022005013A MX 2022005013 A MX2022005013 A MX 2022005013A MX 2022005013 A MX2022005013 A MX 2022005013A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- making
- same
- processes
- amphetamine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
Se describen compuestos y composiciones de d-anfetamina que comprenden por lo menos un ácido orgánico ligado covalentemente a d-anfetamina, que tiene la estructura de o, una sal de la misma, un derivado de la misma, o una combinación de los mismos. También se describen métodos para fabricar y utilizar los mismos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862752324P | 2018-10-29 | 2018-10-29 | |
US201962800494P | 2019-02-02 | 2019-02-02 | |
US16/667,807 US11174229B2 (en) | 2018-10-29 | 2019-10-29 | D-amphetamine compounds, compositions, and processes for making and using the same |
PCT/US2020/019146 WO2021086427A1 (en) | 2018-10-29 | 2020-02-21 | D-amphetamine compounds, compositions, and processes for making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022005013A true MX2022005013A (es) | 2022-08-10 |
Family
ID=70328134
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022005013A MX2022005013A (es) | 2018-10-29 | 2020-02-21 | Compuestos, composiciones de d-anfetamina, y procedimientos para fabricar y utilizar los mismos. |
MX2022005012A MX2022005012A (es) | 2018-10-29 | 2020-02-21 | Compuestos, composiciones de d-anfetamina, y procedimientos para fabricar y utilizar los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022005012A MX2022005012A (es) | 2018-10-29 | 2020-02-21 | Compuestos, composiciones de d-anfetamina, y procedimientos para fabricar y utilizar los mismos. |
Country Status (12)
Country | Link |
---|---|
US (3) | US11136295B2 (es) |
EP (2) | EP4051269A4 (es) |
JP (2) | JP2023501968A (es) |
KR (2) | KR20220088727A (es) |
CN (2) | CN114746092A (es) |
AU (2) | AU2020372736A1 (es) |
BR (2) | BR112022008208A2 (es) |
CA (2) | CA3158405A1 (es) |
IL (2) | IL292497A (es) |
MX (2) | MX2022005013A (es) |
WO (2) | WO2021086427A1 (es) |
ZA (2) | ZA202204678B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11136295B2 (en) * | 2018-10-29 | 2021-10-05 | Kempharm, Inc. | D-amphetamine compounds, compositions, and processes for making and using the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
PT1644019E (pt) | 2003-05-29 | 2012-05-23 | Shire Llc | Compostos de anfetamina resistentes ao abuso |
AU2010252740A1 (en) | 2009-05-26 | 2012-01-12 | Shire Llc | Methods of enhancing selective serotonin reuptake inhibitor effects in mammals |
KR101869885B1 (ko) | 2011-07-28 | 2018-06-25 | 켐팜 인코포레이티드 | 메틸페니데이트 프로드러그, 이의 제조 방법 및 사용 방법 |
US20140073589A1 (en) * | 2012-06-27 | 2014-03-13 | Shire Ag | Amphetamine Prodrugs |
JP6621329B2 (ja) * | 2012-10-05 | 2019-12-18 | スファエラ ファーマ ピーティーイー リミテッド | 新規化合物、それらの合成及びそれらの使用 |
MX2019006670A (es) | 2016-12-11 | 2019-12-16 | Kempharm Inc | Composiciones que comprenden profarmacos de metilfenidato, procedimientos para la elaboracion y uso de los mismos. |
US20200109117A1 (en) * | 2018-10-02 | 2020-04-09 | ACCESS Association | Modified Therapeutic Agent Analogs of Mefenamic Acid |
US11136295B2 (en) * | 2018-10-29 | 2021-10-05 | Kempharm, Inc. | D-amphetamine compounds, compositions, and processes for making and using the same |
-
2019
- 2019-10-29 US US16/667,804 patent/US11136295B2/en active Active
- 2019-10-29 US US16/667,807 patent/US11174229B2/en active Active
-
2020
- 2020-02-21 KR KR1020227016446A patent/KR20220088727A/ko unknown
- 2020-02-21 MX MX2022005013A patent/MX2022005013A/es unknown
- 2020-02-21 EP EP20882891.3A patent/EP4051269A4/en active Pending
- 2020-02-21 MX MX2022005012A patent/MX2022005012A/es unknown
- 2020-02-21 AU AU2020372736A patent/AU2020372736A1/en active Pending
- 2020-02-21 IL IL292497A patent/IL292497A/en unknown
- 2020-02-21 CA CA3158405A patent/CA3158405A1/en active Pending
- 2020-02-21 CN CN202080082883.9A patent/CN114746092A/zh active Pending
- 2020-02-21 KR KR1020227016414A patent/KR20220091508A/ko active Search and Examination
- 2020-02-21 WO PCT/US2020/019146 patent/WO2021086427A1/en unknown
- 2020-02-21 JP JP2022525745A patent/JP2023501968A/ja active Pending
- 2020-02-21 EP EP20882591.9A patent/EP4051268A4/en active Pending
- 2020-02-21 IL IL292496A patent/IL292496A/en unknown
- 2020-02-21 WO PCT/US2020/019140 patent/WO2021086426A1/en unknown
- 2020-02-21 AU AU2020376735A patent/AU2020376735A1/en active Pending
- 2020-02-21 CN CN202080082873.5A patent/CN114746091A/zh active Pending
- 2020-02-21 BR BR112022008208A patent/BR112022008208A2/pt unknown
- 2020-02-21 JP JP2022525742A patent/JP2023501967A/ja active Pending
- 2020-02-21 CA CA3158404A patent/CA3158404A1/en active Pending
- 2020-02-21 BR BR112022008216A patent/BR112022008216A2/pt unknown
-
2021
- 2021-10-13 US US17/500,680 patent/US20220064116A1/en active Pending
-
2022
- 2022-04-26 ZA ZA2022/04678A patent/ZA202204678B/en unknown
- 2022-04-28 ZA ZA2022/04747A patent/ZA202204747B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP4051268A4 (en) | 2024-01-17 |
US20200131130A1 (en) | 2020-04-30 |
KR20220091508A (ko) | 2022-06-30 |
EP4051268A1 (en) | 2022-09-07 |
CA3158405A1 (en) | 2021-05-06 |
US11174229B2 (en) | 2021-11-16 |
MX2022005012A (es) | 2022-08-08 |
EP4051269A1 (en) | 2022-09-07 |
US20200129497A1 (en) | 2020-04-30 |
WO2021086426A1 (en) | 2021-05-06 |
JP2023501968A (ja) | 2023-01-20 |
WO2021086427A1 (en) | 2021-05-06 |
US20220064116A1 (en) | 2022-03-03 |
BR112022008216A2 (pt) | 2022-07-12 |
CN114746092A (zh) | 2022-07-12 |
US11136295B2 (en) | 2021-10-05 |
JP2023501967A (ja) | 2023-01-20 |
ZA202204747B (en) | 2023-05-31 |
ZA202204678B (en) | 2023-01-25 |
CN114746091A (zh) | 2022-07-12 |
IL292496A (en) | 2022-06-01 |
AU2020372736A1 (en) | 2022-05-12 |
EP4051269A4 (en) | 2023-12-27 |
AU2020376735A1 (en) | 2022-05-12 |
BR112022008208A2 (pt) | 2022-07-12 |
IL292497A (en) | 2022-06-01 |
CA3158404A1 (en) | 2021-05-06 |
KR20220088727A (ko) | 2022-06-28 |
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