CN114732818B - 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用 - Google Patents

一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用 Download PDF

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CN114732818B
CN114732818B CN202210463752.6A CN202210463752A CN114732818B CN 114732818 B CN114732818 B CN 114732818B CN 202210463752 A CN202210463752 A CN 202210463752A CN 114732818 B CN114732818 B CN 114732818B
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tuberculosis
nintedanib
treatment
drug
drugs
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Chinese (zh)
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CN114732818A (zh
Inventor
陆宇
陈效友
祁雪婷
郑璐瑶
付雷
张炜焱
王宁
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Beijing Chest Hospital
Beijing Tuberculosis and Thoracic Tumor Research Institute
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Beijing Chest Hospital
Beijing Tuberculosis and Thoracic Tumor Research Institute
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Priority to CN202210463752.6A priority Critical patent/CN114732818B/zh
Publication of CN114732818A publication Critical patent/CN114732818A/zh
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Publication of CN114732818B publication Critical patent/CN114732818B/zh
Priority to JP2024553621A priority patent/JP7844766B2/ja
Priority to US18/727,731 priority patent/US20250099458A1/en
Priority to PCT/CN2023/081772 priority patent/WO2023207398A1/zh
Priority to ZA2024/05173A priority patent/ZA202405173B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202210463752.6A 2022-04-29 2022-04-29 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用 Active CN114732818B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202210463752.6A CN114732818B (zh) 2022-04-29 2022-04-29 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用
JP2024553621A JP7844766B2 (ja) 2022-04-29 2023-03-16 抗特発性肺線維症薬ニンテダニブの結核を治療するための使用
US18/727,731 US20250099458A1 (en) 2022-04-29 2023-03-16 Use of anti-idiopathic pulmonary fibrosis drug nintedanib in treatment of tuberculosis
PCT/CN2023/081772 WO2023207398A1 (zh) 2022-04-29 2023-03-16 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用
ZA2024/05173A ZA202405173B (en) 2022-04-29 2024-07-02 Use of anti-idiopathic pulmonary fibrosis drug nintedanib in treatment of tuberculosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210463752.6A CN114732818B (zh) 2022-04-29 2022-04-29 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用

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CN114732818A CN114732818A (zh) 2022-07-12
CN114732818B true CN114732818B (zh) 2023-02-10

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US (1) US20250099458A1 (https=)
JP (1) JP7844766B2 (https=)
CN (1) CN114732818B (https=)
WO (1) WO2023207398A1 (https=)
ZA (1) ZA202405173B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732818B (zh) * 2022-04-29 2023-02-10 首都医科大学附属北京胸科医院 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用
CN115645405B (zh) * 2022-11-10 2023-11-21 南方医科大学 顺苯磺酸阿曲库铵在制备抗结核抗生素增效剂中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1857725A (zh) * 2006-04-11 2006-11-08 济南帅华医药科技有限公司 一种含增效剂的复方抗结核药物缓释制剂
EP2311457A1 (en) * 2009-10-19 2011-04-20 Forschungszentrum Borstel Pharmaceutical compositions for treating infections with drug resistant mycobacteria
WO2015107482A1 (en) * 2014-01-17 2015-07-23 Piramal Enterprises Limited Pharmaceutical combination for treatment of tuberculosis
DK3377064T3 (da) * 2016-01-08 2019-09-23 Nerre Therapeutics Ltd Orvepitant til behandling af kronisk hoste
CN107019697A (zh) * 2016-02-02 2017-08-08 瑞阳(苏州)生物科技有限公司 预防或治疗纤维化疾病的药物组合物及其应用
GB201607865D0 (en) * 2016-05-05 2016-06-22 Ucl Business Plc Anti-tuberculous polymersomes
CN105902507A (zh) * 2016-06-12 2016-08-31 佛山市腾瑞医药科技有限公司 一种乙磺酸尼达尼布制剂及其应用
CN114732818B (zh) * 2022-04-29 2023-02-10 首都医科大学附属北京胸科医院 一种抗特发性肺纤维化药物尼达尼布在结核病治疗中的应用

Also Published As

Publication number Publication date
ZA202405173B (en) 2024-07-31
JP2025508098A (ja) 2025-03-21
JP7844766B2 (ja) 2026-04-14
US20250099458A1 (en) 2025-03-27
CN114732818A (zh) 2022-07-12
WO2023207398A1 (zh) 2023-11-02

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