CN114729328A - Tmem59蛋白二聚体或嵌合表达受体改善t细胞功能 - Google Patents
Tmem59蛋白二聚体或嵌合表达受体改善t细胞功能 Download PDFInfo
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- CN114729328A CN114729328A CN202080078623.4A CN202080078623A CN114729328A CN 114729328 A CN114729328 A CN 114729328A CN 202080078623 A CN202080078623 A CN 202080078623A CN 114729328 A CN114729328 A CN 114729328A
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Abstract
涉及一种免疫细胞，所述免疫细胞包含TMEM59蛋白和/或其功能性片段和嵌合抗原受体CAR和/或其编码元件，以及所述免疫细胞在制备治疗肿瘤的药物中的用途。还提供了促进免疫细胞增殖的方法和促进记忆性细胞产生的方法。
Description
PCT国内申请，说明书已公开。
Claims (43)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111073668 | 2019-11-13 | ||
| CN201911107366 | 2019-11-13 | ||
| PCT/CN2020/128440 WO2021093818A1 (zh) | 2019-11-13 | 2020-11-12 | Tmem59蛋白二聚体或嵌合表达受体改善t细胞功能 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114729328A true CN114729328A (zh) | 2022-07-08 |
| CN114729328B CN114729328B (zh) | 2024-05-03 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080078623.4A Active CN114729328B (zh) | 2019-11-13 | 2020-11-12 | Tmem59蛋白二聚体或嵌合表达受体改善t细胞功能 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220380433A1 (zh) |
| EP (1) | EP4060027A4 (zh) |
| JP (1) | JP2023501506A (zh) |
| CN (1) | CN114729328B (zh) |
| WO (1) | WO2021093818A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220195397A1 (en) * | 2019-04-04 | 2022-06-23 | Shanghai Pharmaceuticals Holding Co., Ltd. | Immune cell containing tumor antigen recognition receptor and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105330750A (zh) * | 2015-11-20 | 2016-02-17 | 上海细胞治疗研究院 | 一种快速中止car-t细胞杀伤作用的分子刹车及其用途 |
| CN106029875A (zh) * | 2014-02-14 | 2016-10-12 | 塞勒克提斯公司 | 为了靶向存在于免疫细胞和病理细胞两者上的抗原而工程化的免疫治疗细胞 |
| CN106349389A (zh) * | 2015-07-21 | 2017-01-25 | 上海益杰生物技术有限公司 | 肿瘤特异性抗egfr抗体及其应用 |
| CN106913864A (zh) * | 2017-03-28 | 2017-07-04 | 上海大学 | 融合蛋白tat‑dcf1的新用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109824778B (zh) * | 2015-09-18 | 2022-07-19 | 上海科济制药有限公司 | 抗cd19全人抗体以及靶向cd19的免疫效应细胞 |
| CN106755023A (zh) * | 2015-10-15 | 2017-05-31 | 中国人民解放军军事医学科学院附属医院 | 带安全开关的嵌合抗原受体免疫细胞及其制备方法与应用 |
| CN107129537A (zh) * | 2016-02-29 | 2017-09-05 | 北京赛诺泰生物科技有限公司 | 抗乙型肝炎病毒的免疫反应性细胞 |
-
2020
- 2020-11-12 WO PCT/CN2020/128440 patent/WO2021093818A1/zh unknown
- 2020-11-12 JP JP2022527071A patent/JP2023501506A/ja active Pending
- 2020-11-12 EP EP20888079.9A patent/EP4060027A4/en active Pending
- 2020-11-12 US US17/776,537 patent/US20220380433A1/en active Pending
- 2020-11-12 CN CN202080078623.4A patent/CN114729328B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106029875A (zh) * | 2014-02-14 | 2016-10-12 | 塞勒克提斯公司 | 为了靶向存在于免疫细胞和病理细胞两者上的抗原而工程化的免疫治疗细胞 |
| CN106349389A (zh) * | 2015-07-21 | 2017-01-25 | 上海益杰生物技术有限公司 | 肿瘤特异性抗egfr抗体及其应用 |
| CN105330750A (zh) * | 2015-11-20 | 2016-02-17 | 上海细胞治疗研究院 | 一种快速中止car-t细胞杀伤作用的分子刹车及其用途 |
| CN106913864A (zh) * | 2017-03-28 | 2017-07-04 | 上海大学 | 融合蛋白tat‑dcf1的新用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220380433A1 (en) | 2022-12-01 |
| WO2021093818A1 (zh) | 2021-05-20 |
| EP4060027A4 (en) | 2023-12-27 |
| EP4060027A1 (en) | 2022-09-21 |
| JP2023501506A (ja) | 2023-01-18 |
| CN114729328B (zh) | 2024-05-03 |
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