CN114699341A - Long-acting mosquito repellent and preparation method thereof - Google Patents
Long-acting mosquito repellent and preparation method thereof Download PDFInfo
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- CN114699341A CN114699341A CN202210340648.8A CN202210340648A CN114699341A CN 114699341 A CN114699341 A CN 114699341A CN 202210340648 A CN202210340648 A CN 202210340648A CN 114699341 A CN114699341 A CN 114699341A
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- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to a long-acting mosquito repellent and a preparation method thereof, wherein the long-acting mosquito repellent comprises an oil phase component and a water phase component, the oil phase component comprises a mosquito repellent active component and an oil-soluble excipient, and the mosquito repellent active component comprises citronella oil, clove oil, lemongrass oil or a mixture thereof. The invention aims to provide a pure herbal formula mosquito repellent which is convenient to obtain materials, simple in process, capable of effectively avoiding skin irritation and capable of repelling mosquitoes for a long time.
Description
Technical Field
The invention belongs to the field of vector biological control, and particularly relates to a long-acting mosquito repellent and a preparation method thereof.
Background
The mosquito repellent in the form of cream, gel and emulsion is usually applied on the skin to prevent mosquito bite in outdoor conditions, but the mosquito repellent cream formulation contains synthetic chemicals, is not biodegradable and has destructive effect on environmental ecology, for example, the common mosquito repellent amine can dissolve plastics on glasses, watches, etc., has strong odor, produces greasy and burning feeling, and even causes discomfort to human body.
Disclosure of Invention
The invention aims to provide a formula and a preparation method of a long-acting mosquito repellent, and the long-acting mosquito repellent with no skin irritation, long-lasting mosquito repellent effect and herbal formula is prepared.
In order to realize the purpose, the invention adopts the following technical scheme:
a long-acting mosquito repellent comprises an oil phase component and a water phase component, wherein the total mass percentage of the long-acting mosquito repellent is 100%, the oil phase component comprises a mosquito repellent active component and an oil-soluble excipient,
the mosquito-repellent active component comprises citronella oil, clove oil, lemongrass oil or a mixture thereof;
the oil-soluble excipient comprises 3 to 4 percent of glyceryl monostearate, 2 to 3 percent of cetyl alcohol, 2 to 3.5 percent of stearic acid, 0.25 to 1.0 percent of vanillin, 0.1 to 0.3 percent of EDTA disodium, 0.05 to 0.25 percent of methyl p-hydroxybenzoate, 0.02 to 0.04 percent of sodium benzoate, 0.75 to 1.25 percent of light liquid paraffin, 0.25 to 0.75 percent of isopropyl myristate, 0.75 to 1.75 percent of polydimethylsiloxane, 0.75 to 1.0 percent of vitamin E and 0.75 to 1.0 percent of rosemary oil;
the water phase component comprises 2-3% of polyethylene glycol, 0.5-1% of polysorbate 20, 0.5-2.0% of glycerol, 0.05-0.2% of hydroxypropyl ester and softened water.
Preferably, the mosquito-repellent active ingredients comprise 8.25% of citronella oil, 3.96% of clove oil and 4.02% of lemongrass oil.
The invention also provides a preparation method of the long-acting mosquito repellent, which comprises the following specific steps:
1) uniformly mixing light liquid paraffin, rosemary oil, glyceryl monostearate, stearic acid, vanillin, vitamin E, EDTA disodium, methylparaben and sodium benzoate, stirring, heating in a water bath to 65 ℃, stirring at the speed of 200rpm, stirring until white floccules are completely dissolved, adding polydimethylsiloxane, cetyl alcohol and isopropyl myristate, and uniformly stirring to obtain an oil-soluble excipient;
2) heating demineralized water to 65 deg.C, adding polyethylene glycol, polysorbate 20, glycerol, and p-hydroxypropyl into demineralized water under slowly stirring, and slowly stirring to form water phase emulsifier;
3) the citronella oil, clove oil and lemongrass oil were gently added to the oil phase with stirring at 55 + -2 deg.C with stirring at 200rpm, and then the prepared aqueous phase was slowly added to emulsify the mixture and held at 60 + -2 deg.C with stirring at 800rpm for 1 hour.
4) And keeping natural cooling, and waiting for the product to solidify.
The invention has the beneficial effects that:
(1) the citronella oil, clove oil and lemongrass oil in the effective components of the mosquito repellent are pure herbal formulas, and have good stable and synergistic mosquito repellent effects with other components such as a dispersant, a synergist, a chelating agent, an antioxidant and the like; particularly, when the percentage content of the citronella oil is 8.25 percent, the percentage content of the clove oil is 3.96 percent, and the percentage content of the lemongrass oil is 4.02 percent, the mosquito repelling rate reaches 96 percent at the maximum, and the mosquito repelling effective time reaches 285 minutes;
(2) the mosquito repellent has the advantages that through the observation of skin irritation reaction for 72 hours, the PII value is 0, and the skin has no adverse reactions such as erythema or edema, and the experiment shows that the mosquito repellent has no irritation to the skin;
(3) the observation of skin histopathology proves that the Epidermis (ED), the dermis (D), the Sebaceous Gland (SG) and the Hair Follicle (HF) have no abnormal reaction, and the mosquito repellent is suitable for people of different ages;
(4) the mosquito repellent disclosed by the invention is convenient in material taking, simple in process and good in application prospect.
Detailed Description
In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.
Example 1
(1) The components are mixed according to the following proportion: the mosquito repellent active components comprise citronella oil, clove oil and lemongrass oil;
the oil soluble excipient comprises 3% glyceryl monostearate, 2% cetyl alcohol, 2% stearic acid, 0.25% vanillin, 0.1% disodium EDTA, 0.05% methyl paraben, 0.02% sodium benzoate, 0.75% light liquid paraffin, 0.25% isopropyl myristate, 0.75% polydimethylsiloxane, 0.75% vitamin E, 0.75% rosemary oil;
the water phase component comprises 2% polyethylene glycol, 0.5% polysorbate 20, 0.5% glycerin, 0.05% hydroxypropyl ester and softened water;
(2) uniformly mixing light liquid paraffin, rosemary oil, glyceryl monostearate, stearic acid, vanillin, vitamin E, EDTA disodium, methylparaben and sodium benzoate, stirring, heating in a water bath to 65 ℃, stirring at the speed of 200rpm, stirring until white floccules are completely dissolved, adding polydimethylsiloxane, cetyl alcohol and isopropyl myristate, and uniformly stirring to obtain an oil-soluble excipient;
(3) heating demineralized water to 65 deg.C, adding polyethylene glycol, polysorbate 20, glycerol, and p-hydroxypropyl into demineralized water under slowly stirring, and slowly stirring to form water phase emulsifier;
(4) controlling the temperature at 55 +/-2 ℃, gently adding the citronella oil, the clove oil and the lemongrass oil into the oil phase under stirring, wherein the stirring speed is 200rpm, then slowly adding the prepared water phase to emulsify the mixture, and keeping the mixture for 1 hour under the conditions of 60 +/-2 ℃ and the stirring speed of 800 rpm;
(5) and (5) keeping natural cooling, and waiting for the product to solidify.
Example 2
The mosquito repellent active components comprise clove oil and lemongrass oil; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 3
The mosquito repellent active components are citronella and lemon grass; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 4
The mosquito repellent active components comprise citronella and clove; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 5
The mosquito-repellent active component is wild turmeric; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 6
The mosquito-repellent active component is patchouli; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 7
The mosquito-repellent active component is mint; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 8
The mosquito-repellent active component is lemon grass; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 9
The mosquito-repellent active component is clove; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
example 10
The mosquito-repellent active component is citronella; the oil-soluble excipient and the water-phase components were the same as in example 1; the procedure was the same as in example 1;
table 1 shows the repellency rates of the different mosquito repellent components
Note: ED50 is the median effective amount, which refers to the amount of drug that causes 50% of the maximal response intensity.
Table 1 shows that the combined repellent rate of the citronella oil, the clove oil and the lemongrass oil is the highest.
Example 11
(1) The components are mixed according to the following proportion: the mosquito repellent active components comprise 9.25% of citronella oil, 4.02% of clove oil and 4.60% of lemongrass oil;
the oil soluble excipient comprises 4% glyceryl monostearate, 3% cetyl alcohol, 3.5% stearic acid, 1.0% vanillin, 0.3% disodium EDTA, 0.25% methyl paraben, 0.04% sodium benzoate, 1.25% light liquid paraffin, 0.75% isopropyl myristate, 1.75% polydimethylsiloxane, 1.0% vitamin E, 1.0% rosemary oil;
the water phase component comprises 3% of polyethylene glycol, 1% of polysorbate 20, 2.0% of glycerin, 0.2% of hydroxypropyl ester and softened water;
(2) uniformly mixing light liquid paraffin, rosemary oil, glyceryl monostearate, stearic acid, vanillin, vitamin E, EDTA disodium, methylparaben and sodium benzoate, stirring, heating in a water bath to 65 ℃, stirring at the speed of 200rpm, stirring until white floccules are completely dissolved, adding polydimethylsiloxane, cetyl alcohol and isopropyl myristate, and uniformly stirring to obtain an oil-soluble excipient;
(3) heating softened water to 65 deg.C, adding polyethylene glycol, polysorbate 20, glycerol, and p-hydroxypropyl into softened water under slowly stirring, and slowly stirring to form water phase emulsifier;
(4) controlling the temperature at 55 +/-2 ℃, gently adding the citronella oil, the clove oil and the lemongrass oil into the oil phase under stirring, stirring at the speed of 200rpm, then slowly adding the prepared water phase to emulsify the mixture, and keeping the mixture for 1 hour under the conditions of 60 +/-2 ℃ and the stirring speed of 800 rpm;
(5) and keeping natural cooling, and waiting for the product to solidify.
Example 12
The mosquito repellent active components comprise 8.76% of citronella oil, 4.29% of clove oil and 4.13% of lemongrass oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was as in example 11;
example 13
The mosquito repellent active components comprise 10.13% of citronella oil, 4.17% of lemongrass oil and 4.08% of clove oil; the oil-soluble excipient and the aqueous phase components were the same as in example 11; the procedure was the same as in example 11;
example 14
The mosquito repellent active components comprise 9.47% of citronella oil, 4.53% of lemongrass oil and 4.11% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 15
The mosquito repellent active components comprise 9.86% of citronella oil, 4.07% of lemongrass oil and 4.45% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 16
The mosquito repellent active components comprise 9.63% of citronella oil, 4.29% of lemongrass oil and 4.15% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 17
The mosquito repellent active components comprise 8.26% of citronella oil, 3.96% of lemongrass oil and 4.02% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 18
The mosquito repellent active components comprise 10.03% of citronella oil, 9.86% of lemongrass oil and 10.00% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 19
The mosquito-repellent active components comprise 10.03% of citronella oil, 9.86% of lemongrass oil and 10.00% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
example 20
The mosquito-repellent active components comprise 9.87% of citronella oil, 10.02% of lemongrass oil and 10.00% of clove oil; the oil-soluble excipient and the water-phase components were the same as in example 11; the procedure was the same as in example 11;
TABLE 2 mosquito repellent protection time of citronella oil, lemongrass oil and clove oil in different proportions
Table 2 shows that when the content of the citronella oil is 8.26%, the content of the lemongrass oil is 3.96% and the content of the clove oil is 4.02%, the mosquito repelling protection time is longest and the mosquito repelling effect is best.
Performance testing
Physical and chemical parameters
The long-acting mosquito repellent prepared by the invention is an oil-in-water emulsion, has good uniformity and spreading capability, and is acceptable in smell and color. The pH values were measured to be 7.3. + -. 0.08 and the densities (1.02. + -. 0.01 g/mL), respectively.
Acute skin irritation
After 72 hours of treatment period, no adverse skin reaction such as erythema or edema is observed in the prepared long-acting mosquito repellent, and the PII value is 0, which indicates that the mosquito repellent has no irritation to skin.
Repeated administration skin toxicity
The observation of skin histopathology proves that the mosquito repellent has no abnormal reaction on Epidermis (ED), dermis (D), Sebaceous Gland (SG) and Hair Follicle (HF), and is suitable for people of different ages.
Average effective guard time test:
40 testers with qualified offensive power (half of men and women, no wine, tea or coffee should be drunk before and during the test, and products containing essence should not be used) are selected and divided into 2 groups, wherein the 1 st group corresponds to the long-acting mosquito repellent prepared in the embodiment, the 2 nd group corresponds to the marketed Thai mosquito repellent 'green plant extract' (effective mosquito repellent components comprise menthol and camphor), and each group comprises 5 men and 5 women. One hand of each tester of each group is uniformly smeared with 1mL of mosquito repellent cream on the skin at the same position of 50mm multiplied by 50mm, the skin without the mosquito repellent cream is exposed at the same position of the skin by 40mm, the rest skin is tightly shielded, and the other hand is blank control. In the test process, the arm coated with the mosquito repellent paste is exposed for 3 minutes at an interval of 30 minutes, and whether mosquitoes come and come, and stop falling and blood suction are observed. The time when each tester starts to bite by mosquitoes on hands in each group is the effective protection time, and the average effective protection time (min) of each group is recorded and calculated. During the test, a contrast hand firstly performs a contrast test, the test insects with qualified attack force can continue the test, and the test insects with unqualified attack force need to be replaced by the qualified test insects for the test.
Table 3 shows the results of the test for an average effective protection time of 8.26% for citronella oil, 3.96% for lemongrass oil and 4.02% for clove oil.
Claims (3)
1. A long-acting mosquito repellent is characterized in that: comprises an oil phase component and a water phase component in percentage by mass, wherein the oil phase component comprises a mosquito repellent active component and an oil soluble excipient,
the mosquito-repellent active component comprises citronella oil, clove oil, lemongrass oil or a mixture thereof;
the oil-soluble excipient comprises 3 to 4 percent of glyceryl monostearate, 2 to 3 percent of cetyl alcohol, 2 to 3.5 percent of stearic acid, 0.25 to 1.0 percent of vanillin, 0.1 to 0.3 percent of EDTA disodium, 0.05 to 0.25 percent of methyl p-hydroxybenzoate, 0.02 to 0.04 percent of sodium benzoate, 0.75 to 1.25 percent of light liquid paraffin, 0.25 to 0.75 percent of isopropyl myristate, 0.75 to 1.75 percent of polydimethylsiloxane, 0.75 to 1.0 percent of vitamin E and 0.75 to 1.0 percent of rosemary oil;
the water phase component comprises 2-3% of polyethylene glycol, 0.5-1% of polysorbate 20, 0.5-2.0% of glycerol, 0.05-0.2% of hydroxypropyl ester and softened water.
2. The long-acting mosquito repellent according to claim 1, characterized in that: the mosquito repellent active ingredients comprise 8.25% of citronella oil, 3.96% of clove oil and 4.02% of lemongrass oil.
3. The preparation method of the long-acting mosquito repellent according to claim 1, characterized in that: the method comprises the following steps:
1) uniformly mixing light liquid paraffin, rosemary oil, glyceryl monostearate, stearic acid, vanillin, vitamin E, EDTA disodium, methylparaben and sodium benzoate, stirring, heating in a water bath to 65 ℃, stirring at the speed of 200rpm, stirring until white floccules are completely dissolved, adding polydimethylsiloxane, cetyl alcohol and isopropyl myristate, and uniformly stirring to obtain an oil-soluble excipient;
2) heating demineralized water to 65 deg.C, adding polyethylene glycol, polysorbate 20, glycerol, and p-hydroxypropyl into demineralized water under slowly stirring, and slowly stirring to form water phase emulsifier;
3) the citronella oil, clove oil and lemongrass oil were gently added to the oil phase with stirring at 55 + -2 deg.C with stirring at 200rpm, and then the prepared aqueous phase was slowly added to emulsify the mixture and held at 60 + -2 deg.C with stirring at 800rpm for 1 hour.
4) And keeping natural cooling, and waiting for the product to solidify.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210340648.8A CN114699341A (en) | 2022-04-02 | 2022-04-02 | Long-acting mosquito repellent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210340648.8A CN114699341A (en) | 2022-04-02 | 2022-04-02 | Long-acting mosquito repellent and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614092A (en) * | 2012-04-26 | 2012-08-01 | 福建省金鹿日化股份有限公司 | Mosquito driving ointment and preparation method thereof |
| US9326524B1 (en) * | 2014-02-27 | 2016-05-03 | Nantucket Spider, LLC | Insect repellent compositions |
| CN106614827A (en) * | 2016-12-28 | 2017-05-10 | 深圳市鸿邦礼品有限公司 | Mosquito-repelling combination and preparation method thereof and application |
| CN107184510A (en) * | 2017-05-17 | 2017-09-22 | 苏州宝丽洁日化有限公司 | A kind of composition, mosquito-eliminating wet tissue containing said composition and preparation method thereof |
| CN110742097A (en) * | 2019-10-30 | 2020-02-04 | 深圳赛利特瑞环保科技有限公司 | Microcapsule slow-release type essential oil mosquito-repellent gel |
-
2022
- 2022-04-02 CN CN202210340648.8A patent/CN114699341A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614092A (en) * | 2012-04-26 | 2012-08-01 | 福建省金鹿日化股份有限公司 | Mosquito driving ointment and preparation method thereof |
| US9326524B1 (en) * | 2014-02-27 | 2016-05-03 | Nantucket Spider, LLC | Insect repellent compositions |
| CN106614827A (en) * | 2016-12-28 | 2017-05-10 | 深圳市鸿邦礼品有限公司 | Mosquito-repelling combination and preparation method thereof and application |
| CN107184510A (en) * | 2017-05-17 | 2017-09-22 | 苏州宝丽洁日化有限公司 | A kind of composition, mosquito-eliminating wet tissue containing said composition and preparation method thereof |
| CN110742097A (en) * | 2019-10-30 | 2020-02-04 | 深圳赛利特瑞环保科技有限公司 | Microcapsule slow-release type essential oil mosquito-repellent gel |
Non-Patent Citations (1)
| Title |
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