CN114681363A - 一种富有干细胞活性因子和sod的射线防护喷雾 - Google Patents
一种富有干细胞活性因子和sod的射线防护喷雾 Download PDFInfo
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Abstract
本发明公开了一种富有干细胞活性因子和SOD的射线防护喷雾，将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，具有提高成纤维细胞的增殖能力，促进皮肤的成纤维细胞合成胶原蛋白的能力，修复细胞、改善细胞代谢、激活衰老细胞，增强肌肤对外界环境的耐受力。
Description
技术领域
本发明涉及防护喷雾技术领域，具体是一种富有干细胞活性因子和SOD的射线防护喷雾。
背景技术
在一些损伤因素的作用下，如疾病、创伤、环境污染、离子辐射、紫外线照射、化学药物等可诱导机体产生大量的活性氧自由基(ROS)，活性氧自由基可以引起细胞膜过氧化，形成大量的脂质过氧化物(LPO)及其降解产物丙二醛(MDA)，使得正常的膜结构受到破坏，通透性增高，线粒体肿胀，直接攻击核酸，使DNA、RNA交联断裂，蛋白质变性，从而导致机体衰老与多种疾病发生。
SOD超氧化物歧化酶是超氧化物歧化酶的简称，是氧自由基的专一清除剂，具有极强的抗炎症、抗辐射、抗衰老及美容作用，能治疗现代医学认为无法治疗的多种疾病，能有效的消除或减少皱纹、青春痘及色素沉着(包括雀斑、黄褐斑、蝴蝶斑、妊娠斑、老年斑、晒斑)，现有的射线防护喷雾会出现刺激性反应，同时由于一般防晒为乳液基质，而这适于微生物生长，易变质腐败，要达到防水和耐水也比较困难。
发明内容
本发明的目的在于提供一种富有干细胞活性因子和SOD的射线防护喷雾，以解决上述背景技术中提出的现有的射线防护喷雾会出现刺激性反应，同时由于一般防晒为乳液基质，而这适于微生物生长，易变质腐败，要达到防水和耐水也比较困难的问题。
为实现上述目的，本发明提供如下技术方案：
一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：
SOD超氧化物歧化酶0.02-0.6份、干细胞分泌因子1-1.5份、甘油2-4份、二氧化钛1-1.5份、尿囊素0.1-1.2份、生育酚0.2-0.8份、聚丙烯酰胺0.2-0.6份、丁二醇0.1-0.7 份、维生素C 0.2-0.9份、褐藻糖胶0.05-0.6份、海藻提取液0.7-1.6份、去离子水40-75 份。
作为本发明进一步的方案：所述的SOD超氧化物歧化酶选自动物提取SOD超氧化物歧化酶、基因重组SOD超氧化物歧化酶、月桂酸修饰SOD超氧化物歧化酶中的一种；
作为本发明再进一步的方案：一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：SOD超氧化物歧化酶0.02份、干细胞分泌因子1份、甘油2份、二氧化钛1份、尿囊素0.1份、生育酚0.2份、聚丙烯酰胺0.2份、丁二醇0.1份、维生素C 0.2份、褐藻糖胶0.05份、海藻提取液0.7份、去离子水40份。
作为本发明再进一步的方案：一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：SOD超氧化物歧化酶0.6份、干细胞分泌因子1.5份、甘油4份、二氧化钛1.5份、尿囊素1.2份、生育酚0.8份、聚丙烯酰胺0.6份、丁二醇0.7份、维生素C 0.9份、褐藻糖胶0.6份、海藻提取液1.6份、去离子水75份。
一种富有干细胞活性因子和SOD的射线防护喷雾的制备方法，包括以下步骤：
1)分别称取配方量的SOD超氧化物歧化酶0.02-0.6份、干细胞分泌因子1-1.5份、甘油2-4份、二氧化钛1-1.5份、尿囊素0.1-1.2份、生育酚0.2-0.8份、聚丙烯酰胺0.2-0.6份、丁二醇0.1-0.7份、维生素C 0.2-0.9份、褐藻糖胶0.05-0.6份、海藻提取液0.7-1.6 份、去离子水40-75份；
2)将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；
3)将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入步骤(2)所制备的混合液中，混合溶解，得到混合酶液；
4)在步骤3)获得的混合酶液中加入干细胞分泌因子；
5)将步骤4)获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
与现有技术相比，本发明的有益效果是：
1)干细胞分泌因子可以支持干细胞自身的生物活性功能，同时改善机体整体或者局部的微环境，提高成纤维细胞的增殖能力，且能提高皮肤的成纤维细胞合成胶原蛋白的能力，促进机体组织再生和器官功能恢复，刺激机体其他成体细胞的抗衰老作用，治愈抗衰老最根本的途径是修复细胞、改善细胞代谢、激活衰老细胞的功能；
2)本发明技术方案，具有提高成纤维细胞的增殖能力，促进皮肤的成纤维细胞合成胶原蛋白的能力，修复细胞、改善细胞代谢、激活衰老细胞，增强肌肤对外界环境的耐受力；
3)本发明解决了现有SOD超氧化物歧化酶的射线防护喷雾使用时直接与皮肤接触，可能会引起皮肤刺激性反应、耐水效果差的问题；
4)本发明的SOD超氧化物歧化酶的射线防护喷雾具有，收敛，抗氧化，去自由基的作用。
具体实施方式
本发明技术方案，具有提高成纤维细胞的增殖能力，促进皮肤的成纤维细胞合成胶原蛋白的能力，修复细胞、改善细胞代谢、激活衰老细胞，增强肌肤对外界环境的耐受力，干细胞分泌因子可以支持干细胞自身的生物活性功能，同时改善机体整体或者局部的微环境，提高成纤维细胞的增殖能力，且能提高皮肤的成纤维细胞合成胶原蛋白的能力，促进机体组织再生和器官功能恢复，刺激机体其他成体细胞的抗衰老作用，治愈抗衰老最根本的途径是修复细胞、改善细胞代谢、激活衰老细胞的功能。
下面结合具体实施方式对本发明的技术方案作进一步详细地说明。
实施例1
分别称取配方量的SOD超氧化物歧化酶0.02份、干细胞分泌因子1份、甘油2份、二氧化钛1份、尿囊素0.1份、生育酚0.2份、聚丙烯酰胺0.2份、丁二醇0.1份、维生素C 0.2份、褐藻糖胶0.05份、海藻提取液0.7份、去离子水40份；将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
实施例2
分别称取配方量的SOD超氧化物歧化酶0.1份、干细胞分泌因子1.1份、甘油2.4份、二氧化钛1.1份、尿囊素0.3份、生育酚0.4份、聚丙烯酰胺0.3份、丁二醇0.2份、维生素C 0.3份、褐藻糖胶0.1份、海藻提取液0.9份、去离子水45份；将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
实施例3
分别称取配方量的SOD超氧化物歧化酶0.3份、干细胞分泌因子1.2份、甘油2.7份、二氧化钛1.2份、尿囊素0.5份、生育酚0.5份、聚丙烯酰胺0.4份、丁二醇0.3份、维生素C 0.4份、褐藻糖胶0.3份、海藻提取液1份、去离子水50份；将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
实施例4
分别称取配方量的SOD超氧化物歧化酶0.4份、干细胞分泌因子1.3份、甘油3份、二氧化钛1.3份、尿囊素0.8份、生育酚0.6份、聚丙烯酰胺0.5份、丁二醇0.4份、维生素C 0.6份、褐藻糖胶0.45份、海藻提取液1.2份、去离子水65份；将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
实施例5
分别称取配方量的SOD超氧化物歧化酶0.6份、干细胞分泌因子1.5份、甘油4份、二氧化钛1.5份、尿囊素1.2份、生育酚0.8份、聚丙烯酰胺0.6份、丁二醇0.7份、维生素C 0.9份、褐藻糖胶0.6份、海藻提取液1.6份、去离子水75份；将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入所制备的混合液中，混合溶解，得到混合酶液；在获得的混合酶液中加入干细胞分泌因子；将获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
对比例1
对比例1与实施例3的不同之处在于，对比例1中不含SOD超氧化物歧化酶，其余与实施例3相同。
对比例2
对比例2与实施例3的不同之处在于，对比例2中不含干细胞分泌因子，其余与实施例3相同。
对比例3
对比例3与实施例3的不同之处在于，对比例3中不含SOD超氧化物歧化酶和干细胞分泌因子，其余与实施例3相同。
经过实验对比，在射线防护喷雾中加入SOD超氧化物歧化酶和干细胞分泌因子具有提高成纤维细胞的增殖能力，促进皮肤的成纤维细胞合成胶原蛋白的能力，修复细胞、改善细胞代谢、激活衰老细胞，增强肌肤对外界环境的耐受力，干细胞分泌因子可以支持干细胞自身的生物活性功能，同时改善机体整体或者局部的微环境，提高成纤维细胞的增殖能力，且能提高皮肤的成纤维细胞合成胶原蛋白的能力，促进机体组织再生和器官功能恢复，刺激机体其他成体细胞的抗衰老作用，治愈抗衰老最根本的途径是修复细胞、改善细胞代谢、激活衰老细胞的功能。
上面对本发明的较佳实施方式作了详细说明，但是本发明并不限于上述实施方式，在本领域的普通技术人员所具备的知识范围内，还可以在不脱离本发明宗旨的前提下作出各种变化。
Claims (5)
1.一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：
SOD超氧化物歧化酶0.02-0.6份、干细胞分泌因子1-1.5份、甘油2-4份、二氧化钛1-1.5份、尿囊素0.1-1.2份、生育酚0.2-0.8份、聚丙烯酰胺0.2-0.6份、丁二醇0.1-0.7份、维生素C 0.2-0.9份、褐藻糖胶0.05-0.6份、海藻提取液0.7-1.6份、去离子水40-75份。
2.根据权利要求1所述的一种富有干细胞活性因子和SOD的射线防护喷雾，其特征在于，所述的SOD超氧化物歧化酶选自动物提取SOD超氧化物歧化酶、基因重组SOD超氧化物歧化酶、月桂酸修饰SOD超氧化物歧化酶中的一种。
3.根据权利要求2所述的一种富有干细胞活性因子和SOD的射线防护喷雾，其特征在于，一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：SOD超氧化物歧化酶0.02份、干细胞分泌因子1份、甘油2份、二氧化钛1份、尿囊素0.1份、生育酚0.2份、聚丙烯酰胺0.2份、丁二醇0.1份、维生素C 0.2份、褐藻糖胶0.05份、海藻提取液0.7份、去离子水40份。
4.根据权利要求3所述的一种富有干细胞活性因子和SOD的射线防护喷雾，其特征在于，一种富有干细胞活性因子和SOD的射线防护喷雾，由以下质量份的组分组成：SOD超氧化物歧化酶0.6份、干细胞分泌因子1.5份、甘油4份、二氧化钛1.5份、尿囊素1.2份、生育酚0.8份、聚丙烯酰胺0.6份、丁二醇0.7份、维生素C 0.9份、褐藻糖胶0.6份、海藻提取液1.6份、去离子水75份。
5.根据权利要求1-4任一所述的一种富有干细胞活性因子和SOD的射线防护喷雾，其特征在于，制备方法包括以下步骤：
1)分别称取配方量的SOD超氧化物歧化酶0.02-0.6份、干细胞分泌因子1-1.5份、甘油2-4份、二氧化钛1-1.5份、尿囊素0.1-1.2份、生育酚0.2-0.8份、聚丙烯酰胺0.2-0.6份、丁二醇0.1-0.7份、维生素C 0.2-0.9份、褐藻糖胶0.05-0.6份、海藻提取液0.7-1.6份、去离子水40-75份；
2)将分别称取的甘油、二氧化钛、尿囊素、生育酚、聚丙烯酰胺、丁二醇、维生素C、褐藻糖胶、海藻提取液份溶于去离子水中并过滤，采用常规高温灭菌后，冷却至25℃以下，得到混合液，备用；
3)将SOD超氧化物歧化酶采用常规辐照灭菌，将灭菌后的SOD超氧化物歧化酶在无菌工作环境下加入步骤(2)所制备的混合液中，混合溶解，得到混合酶液；
4)在步骤3)获得的混合酶液中加入干细胞分泌因子；
5)将步骤4)获得的混合液灌装于具有定量阀门的喷雾瓶中，制得富有干细胞活性因子和SOD超氧化物歧化酶的射线防护喷雾，将产品在25℃以下进行保存。
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202016100075U1 (de) * | 2016-01-11 | 2016-05-23 | Germany Bergmann Biomedicine Gmbh | Neuer Typ von medizinischem Strahlungsschutzspray |
| CN105920589A (zh) * | 2016-04-28 | 2016-09-07 | 福建省乐华医药科技有限公司 | 医用射线防护喷剂及其生产工艺 |
| CN108815085A (zh) * | 2018-08-31 | 2018-11-16 | 黄河科技学院 | 一种防晒剂及其制备方法和应用 |
| CN109700754A (zh) * | 2019-02-27 | 2019-05-03 | 广东柏俐臣生物科技有限公司 | 一种冰肌面部防护喷雾及其制备方法 |
| CN111249339A (zh) * | 2020-03-06 | 2020-06-09 | 大连干细胞与精准医学创新研究院 | 一种预防和修复皮肤损伤的组合物及其制备方法与应用 |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202016100075U1 (de) * | 2016-01-11 | 2016-05-23 | Germany Bergmann Biomedicine Gmbh | Neuer Typ von medizinischem Strahlungsschutzspray |
| CN105920589A (zh) * | 2016-04-28 | 2016-09-07 | 福建省乐华医药科技有限公司 | 医用射线防护喷剂及其生产工艺 |
| CN108815085A (zh) * | 2018-08-31 | 2018-11-16 | 黄河科技学院 | 一种防晒剂及其制备方法和应用 |
| CN109700754A (zh) * | 2019-02-27 | 2019-05-03 | 广东柏俐臣生物科技有限公司 | 一种冰肌面部防护喷雾及其制备方法 |
| CN111249339A (zh) * | 2020-03-06 | 2020-06-09 | 大连干细胞与精准医学创新研究院 | 一种预防和修复皮肤损伤的组合物及其制备方法与应用 |
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