CN114642241A - Composite plant polyphenol chelate and using method thereof - Google Patents
Composite plant polyphenol chelate and using method thereof Download PDFInfo
- Publication number
- CN114642241A CN114642241A CN202210347360.3A CN202210347360A CN114642241A CN 114642241 A CN114642241 A CN 114642241A CN 202210347360 A CN202210347360 A CN 202210347360A CN 114642241 A CN114642241 A CN 114642241A
- Authority
- CN
- China
- Prior art keywords
- chelate
- plant polyphenol
- copper
- composite plant
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000008442 polyphenolic compounds Chemical class 0.000 title claims abstract description 74
- 235000013824 polyphenols Nutrition 0.000 title claims abstract description 73
- 239000013522 chelant Substances 0.000 title claims abstract description 68
- 239000002131 composite material Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 8
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 30
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052802 copper Inorganic materials 0.000 claims abstract description 22
- 239000010949 copper Substances 0.000 claims abstract description 22
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960003321 baicalin Drugs 0.000 claims abstract description 20
- 244000144972 livestock Species 0.000 claims abstract description 18
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical compound [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 claims abstract description 18
- 244000144977 poultry Species 0.000 claims abstract description 17
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003674 animal food additive Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 241000196324 Embryophyta Species 0.000 claims description 71
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000003651 drinking water Substances 0.000 claims description 15
- 235000020188 drinking water Nutrition 0.000 claims description 15
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims description 14
- 239000001263 FEMA 3042 Substances 0.000 claims description 14
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 14
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims description 14
- 229940033123 tannic acid Drugs 0.000 claims description 14
- 235000015523 tannic acid Nutrition 0.000 claims description 14
- 229920002258 tannic acid Polymers 0.000 claims description 14
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 8
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 7
- 239000011592 zinc chloride Substances 0.000 claims description 7
- 235000005074 zinc chloride Nutrition 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- DVECBJCOGJRVPX-UHFFFAOYSA-N butyryl chloride Chemical compound CCCC(Cl)=O DVECBJCOGJRVPX-UHFFFAOYSA-N 0.000 claims description 6
- 230000035622 drinking Effects 0.000 claims description 6
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 claims description 3
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 3
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 claims description 3
- 229940015301 baicalein Drugs 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 22
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 16
- 210000004347 intestinal mucosa Anatomy 0.000 abstract description 11
- 241001465754 Metazoa Species 0.000 abstract description 10
- 230000036541 health Effects 0.000 abstract description 8
- 230000003647 oxidation Effects 0.000 abstract description 8
- 238000007254 oxidation reaction Methods 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 7
- 230000002708 enhancing effect Effects 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 241000282414 Homo sapiens Species 0.000 abstract description 5
- 230000000968 intestinal effect Effects 0.000 abstract description 5
- 230000003871 intestinal function Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 241000700605 Viruses Species 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 239000000654 additive Substances 0.000 abstract description 3
- 230000000996 additive effect Effects 0.000 abstract description 3
- 239000003640 drug residue Substances 0.000 abstract description 3
- 230000036737 immune function Effects 0.000 abstract description 3
- 208000028774 intestinal disease Diseases 0.000 abstract description 3
- 239000000273 veterinary drug Substances 0.000 abstract description 3
- 235000013594 poultry meat Nutrition 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 206010012735 Diarrhoea Diseases 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 241000287828 Gallus gallus Species 0.000 description 8
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 8
- 229940118019 malondialdehyde Drugs 0.000 description 8
- 230000002354 daily effect Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 210000001630 jejunum Anatomy 0.000 description 6
- 102000016938 Catalase Human genes 0.000 description 5
- 108010053835 Catalase Proteins 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 235000021050 feed intake Nutrition 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 210000001198 duodenum Anatomy 0.000 description 4
- 210000003405 ileum Anatomy 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 2
- 229930195730 Aflatoxin Natural products 0.000 description 2
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 239000005409 aflatoxin Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960003760 florfenicol Drugs 0.000 description 2
- 210000002175 goblet cell Anatomy 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022653 Intestinal haemorrhages Diseases 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 206010048849 Myocardial haemorrhage Diseases 0.000 description 1
- 241001591005 Siga Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229940093797 bioflavonoids Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000023011 digestive tract development Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 108010012173 hypophysin Proteins 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 229960001717 tylosin tartrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
Abstract
The invention discloses a composite plant polyphenol chelate and a using method thereof, belonging to the technical field of animal husbandry and comprising baicalin copper, 4' -butyryl puerarin and zinc tannate, wherein the mass ratio of the raw materials is 1: 3-5: 4 to 6. The invention can effectively inhibit intestinal bacteria and viruses, enhance the oxidation resistance and the immune function of the intestinal tract and promote the development of intestinal mucosa, thereby enhancing the intestinal function of livestock and poultry; the composite plant polyphenol chelate can reduce the incidence rate of intestinal diseases, promote the health of livestock and poultry and improve the production performance; compared with the veterinary drug additive for feed, the feed additive has the advantages of no toxic or side effect, no drug residue, no pollution and benefit for animal and human health.
Description
Technical Field
The invention relates to the technical field of animal husbandry, in particular to a composite plant polyphenol chelate and a using method thereof.
Background
Plant polyphenols are a class of secondary metabolites with polyphenol structures widely present in plants, and are bioflavonoids with specific molecular structures. The plant polyphenol is natural antioxidant, has effects of scavenging free radicals, resisting oxidation, resisting aging, resisting allergy, resisting inflammation, enhancing immunity, resisting tumor, preventing cancer, and protecting heart and cerebral vessels. For example, baicalin has antibacterial, diuretic, antiinflammatory, cholesterol reducing, antithrombotic, asthma relieving, pathogenic fire purging, toxic materials clearing away, hemostatic, miscarriage preventing, antiallergic, and spasmolytic effects; tannic acid has been used for treating pharyngolaryngitis, tonsillitis, hemorrhoid and skin herpes, and can be used for relieving diarrhea and intestinal hemorrhage; puerarin has antipyretic, sedative and coronary blood flow increasing effects, and can protect acute myocardial hemorrhage caused by hypophysin. However, most plant polyphenols cannot exert bioactive functions on human beings and animals well due to low solubility to esters and water or low ester/water coefficients. In order to exert the bioactive effect of plant polyphenols well in the protection of human and animal intestinal health, they are generally derivatized according to their physicochemical properties, in order that they are more soluble in water or esters. The animal intestinal tract is a water-soluble system, so that copper baicalin, zinc tannate and 4' -butyrylpuerarin are found to have the characteristic of being easily dissolved in water in the existing derivatives of baicalin, tannic acid and puerarin, and have better antioxidant property compared with the original plant polyphenol. The addition of the substances with the antioxidant function into animal feed or drinking water can improve the intestinal function of livestock and poultry, promote the growth performance and health level of livestock and poultry, reduce the use of growth promoters and therapeutic drugs and lay the foundation for the healthy and sustainable development of the breeding industry.
The intestinal tract of livestock and poultry is not only the largest digestive and absorptive organ in the body of the animal, but also the largest immune organ in the body. The development condition and the function of the intestinal tract are important for the growth and the health of the livestock and poultry. The intestinal tracts of young livestock and poultry are in rapid development, the structure and the function are imperfect, and the digestion and absorption of nutrients and the function of immune barrier have great limitation. In addition, various stresses, bacteria and viruses can promote the intestinal tracts of livestock to generate excessive oxygen free radicals, so that the intestinal mucosa is atrophied, the integrity of the intestinal epithelium and the mucosal barrier are damaged, and the intestinal dysfunction is caused. Therefore, effective measures for improving the livestock and poultry intestinal development condition, maintaining and enhancing the intestinal function are urgently needed in livestock and poultry breeding production, and therefore, the composite plant polyphenol chelate and the using method thereof are provided.
Disclosure of Invention
The invention aims to provide a composite plant polyphenol chelate. The composite plant polyphenol chelate can effectively inhibit intestinal bacteria and viruses, enhance the oxidation resistance and the immune function of the intestinal tract, and promote the development of the intestinal mucosa, thereby enhancing the intestinal function of livestock and poultry. The composite plant polyphenol chelate can reduce the incidence rate of intestinal diseases, promote the health of livestock and poultry and improve the production performance, and has the advantages of no toxic or side effect, no drug residue, no pollution and contribution to the health of animals and human beings compared with a feeding veterinary drug additive.
The invention also aims to provide a using method of the composite plant polyphenol chelate.
In order to solve the problems, the invention adopts the following technical scheme:
a composite plant polyphenol chelate comprises baicalin copper, 4' -butyryl puerarin and zinc tannate, wherein the mass ratio of the raw materials is 1: 3-5: 4 to 6.
In a preferred embodiment of the invention, the copper baicalin is a product prepared from baicalein-7-O-BETA-D-glucuronide and copper chloride in a methanol medium, and has a baicalein content of at least 75% and a copper content of 8.5-9.0%.
As a preferred embodiment of the present invention, the preparation method of the baicalin copper comprises: baicalein-7-O-BETA-D-glucuronide is obtained from scutellaria baicalensis, baicalein-7-O-BETA-D-glucuronide and copper chloride are reacted for 3 hours in a methanol solution at 50 ℃ according to the mass ratio of 2:1 to obtain dregs, and filter residues are dried at low temperature to obtain baicalin copper.
As a preferable scheme of the invention, the 4 '-butyryl puerarin is a product prepared from 8-beta-D-glucopyranose-4', 7-dihydroxy isoflavone and butyryl chloride in acetone and sodium hydroxide medium, wherein the puerarin content is at least 85%, and the butyric acid content is 7.8-8.2%.
As a preferable scheme of the present invention, the preparation method of the 4' -butyrylpuerarin comprises: preparing 8-beta-D-glucopyranose-4', 7-dihydroxyisoflavone from wild radix puerariae according to the mass ratio of 1.5: 1 weighing 8-beta-D-glucopyranose-4 ', 7-dihydroxyisoflavone and butyryl chloride, respectively dissolving in saturated sodium hydroxide solution and acetone solution with the same volume, uniformly mixing the two solutions, reacting for 2.5h at 20 ℃, and separating and filtering to obtain the 4' -butyrylpuerarin.
As a preferable scheme of the invention, the zinc tannate is a product prepared from tannic acid and zinc chloride in a methanol medium, wherein the content of tannic acid is at least 80%, and the content of zinc is 6.0-7.0%.
As a preferable scheme of the invention, the preparation method of the zinc tannate comprises the following steps: obtaining tannic acid from gallnut, wherein the tannic acid and zinc chloride are mixed according to a mass ratio of 1: 1.5 reacting in 45 ℃ ethanol solution for 2h, and spray drying to obtain zinc tannate.
A method for using composite plant polyphenol chelate is to add the composite plant polyphenol chelate into livestock and poultry feed or drinking water according to the weight of 0.01-0.05 percent; mixing the composite plant polyphenol chelate with water for direct drinking; and mixing the composite plant polyphenol chelate with a carrier to prepare a premix, or mixing the composite plant polyphenol chelate with a feed additive and feed raw materials to prepare a premix and a concentrated feed for feeding livestock and poultry.
Compared with the prior art, the invention has the advantages that:
the scheme can effectively inhibit intestinal bacteria and viruses, enhance the oxidation resistance and the immune function of the intestinal tract and promote the development of intestinal mucosa, thereby enhancing the intestinal function of the livestock and poultry; the composite plant polyphenol chelate can reduce the incidence rate of intestinal diseases, promote the health of livestock and poultry and improve the production performance; compared with the veterinary drug additive for feed, the feed additive has the advantages of no toxic or side effect, no drug residue, no pollution and benefit for animal and human health.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
A composite plant polyphenol chelate comprises baicalin copper, 4' -butyryl puerarin and zinc tannate, wherein the mass ratio of the raw materials is 1: 3-5: 4-6; wherein, the baicalin copper is a product prepared from baicalein-7-O-BETA-D-glucuronide and copper chloride in a methanol medium, and the content of the baicalein is at least 75 percent, and the content of the copper is 8.5-9.0 percent; the 4 '-butyrylpuerarin is a product prepared from 8-beta-D-glucopyranose-4', 7-dihydroxy isoflavone and butyryl chloride in acetone and sodium hydroxide medium, wherein the puerarin content is at least 85 percent, and the butyric acid content is 7.8-8.2 percent; the zinc tannate is a product prepared from tannic acid and zinc chloride in a methanol medium, wherein the content of tannic acid is at least 80%, and the content of zinc is 6.0-7.0%.
The preparation method of the baicalin copper comprises the following steps: obtaining baicalein-7-O-BETA-D-glucuronide from scutellaria baicalensis, reacting the baicalein-7-O-BETA-D-glucuronide and copper chloride in a methanol solution at 50 ℃ for 3 hours according to the mass ratio of 2:1 to obtain sediment, and drying filter residues at low temperature to obtain baicalin copper;
the preparation method of the 4' -butyrylpuerarin comprises the following steps: preparing 8-beta-D-glucopyranose-4', 7-dihydroxyisoflavone from wild radix puerariae according to the mass ratio of 1.5: 1, weighing 8-beta-D-glucopyranose-4 ', 7-dihydroxyisoflavone and butyryl chloride, respectively dissolving the two solutions in saturated sodium hydroxide solution and acetone solution which are equal in volume, uniformly mixing the two solutions, reacting for 2.5 hours at the temperature of 20 ℃, and separating and filtering to obtain 4' -butyrylpuerarin;
the preparation method of the zinc tannate comprises the following steps: obtaining tannin from gallnuts, wherein the mass ratio of tannic acid to zinc chloride is 1: 1.5 reacting in 45 ℃ ethanol solution for 2h, and spray drying to obtain zinc tannate.
Example 1:
according to the mass ratio of baicalin copper, 4' -butyrylpuerarin and zinc tannate of 1: 4: and 5, combining, and uniformly mixing the compound to obtain the compound plant polyphenol chelate.
The composite plant polyphenol chelate is suitable for piglets in a drinking water and drenching mode, and has obvious application effect.
The compound plant polyphenol chelate is taken by the piglets in a drinking way. 24 piglets with age of 7 days, 2.1 +/-0.5 kg, grown Du, are selected and divided into 3 groups, no medicine or health-care agent is added into drinking water of a blank control group, a test I group takes doxycycline and amoxicillin mixed agent 0.5g/L through drinking water, a test II group receives the composite plant polyphenol chelate 0.5g/L through drinking water, and the weight, the diarrhea incidence rate and the diarrhea index of the piglets after 21-day-old test are completed are counted. The results are shown in Table 1.
TABLE 1 influence of the addition of the composite plant polyphenol chelate to drinking water on piglets
Note: differences in the shoulder-marked letters on the same row indicate significant differences (p < 0.05). The same applies to the following.
The result shows that compared with a blank control group, the feed additive provided by the invention can obviously improve the body weight of 21-day-old piglets by 10.79%, and reduce the diarrhea incidence rate 92.61% and the diarrhea index 74.07%. Compared with the drug drinking water group, the difference of each observation index is not significant. The above results show that the composite plant polyphenol chelate provided by the embodiment is used for feeding piglets in a drinking mode, and has the effect of replacing medicinal drinking water to ensure the growth performance of the piglets.
Example 2:
according to the mass ratio of baicalin copper, 4' -butyrylpuerarin and zinc tannate of 1: 5: and 4, combining, and uniformly mixing the compound to obtain the compound plant polyphenol chelate.
The composite plant polyphenol chelate is suitable for laying hens in a drinking mode, and has an obvious application effect.
The laying hens which have enteritis are fed with the composite plant polyphenol chelate according to the embodiment in a drinking water mode. 300 Hailan brown laying hens which are infected with mycoplasma and bacilli and cause diarrhea and are in the same day are selected and divided into 3 groups, a control group does not receive any treatment, a test I group receives 0.5g/L tylosin tartrate treatment for 5 days through drinking water, a test II group receives 0.2g/L composite plant polyphenol chelate treatment for 5 days through drinking water, and after the test is finished, the production performance, the diarrhea incidence rate and the intestinal tract score are counted. The results are shown in Table 2.
TABLE 2 influence of addition of the composite plant polyphenol chelate to drinking water on laying hens
The result shows that compared with a control group which is not treated, the feed additive provided by the invention can obviously improve the feed intake of laying hens by 35.46% and the laying rate by 51.45%, reduce the diarrhea rate by 51.6% and reduce the intestinal tract score by 45.25%. Compared with a drinking water drug treatment group, the feed additive has the advantages of obviously improving the laying rate, reducing the diarrhea incidence rate and having no obvious difference on the feed intake and the intestinal tract score. The results show that the composite plant polyphenol chelate provided by the embodiment is used for feeding laying hens in a drinking mode, the laying performance and the feed intake of the laying hens are ensured to be equivalent to the effect of the medicine, and the effect of relieving the diarrhea incidence rate and the intestinal tract score of the laying hens suffering from enteritis is better than the effect of the medicine.
Example 3:
according to the mass ratio of baicalin copper, 4' -butyrylpuerarin and zinc tannate of 1: 3: and 6, combining, and uniformly mixing the compound to obtain the compound plant polyphenol chelate.
The composite plant polyphenol chelate is suitable for suckling piglets and has obvious application effect.
The compound plant polyphenol chelate is used for feeding weaned piglets. The 72 10 day old suckling pigs were divided into three groups of three replicates (pens), 8 pigs per pen. The source, the age in days, the body weight of the piglets are close, and the sexes are consistent. The basic daily ration is fed every day, wherein the blank control group is not added with the compound plant polyphenol chelate and florfenicol premix, the test I group is added with 100mg/kg of florfenicol, and the test II group is added with 0.01 percent of the compound plant polyphenol chelate. Feeding for 21 days. The results are shown in tables 3, 4, 5 and 6.
TABLE 3 Effect of adding Compound plant Polyphenol chelate on growth Performance of weaned piglets
TABLE 4 influence of the addition of the Complex plant Polyphenol chelate on the number of cells involved in the jejunal mucosal immunization of weaned piglets
TABLE 5 Effect of the addition of Complex plant Polyphenol chelate on the height of intestinal villi/depth of crypt in weaned piglets
TABLE 6 Effect of the addition of Complex plant Polyphenol chelate on the antioxidant Capacity of weaned piglet intestinal mucosa
The data in tables 3-6 show that when the composite plant polyphenol chelate provided by the invention is added into feed, compared with a blank control group, the daily gain of piglets is increased by 15.81%, the feed-weight ratio is reduced by 7.22%, and the diarrhea rate is reduced by 59.21%; the number of lymphocytes, mast cells and goblet cells in jejunal cells is increased by 21.87%, 30.34% and 32.61% respectively; the ratio of villus height to crypt depth of duodenum, jejunum and ileum is respectively improved by 21.43 percent, 25.74 percent and 19.56 percent; the content of Malondialdehyde (MDA) in the intestinal mucosa is reduced by 24.30 percent, and the activity of superoxide dismutase (SOD) is improved by 24.15 percent and the activity of Catalase (CAT) is improved by 30.64 percent; compared with a drug group, the daily gain of piglets is improved by 4.06 percent by adding the composite plant polyphenol chelate into feed; the material weight ratio is reduced by 1.64 percent; the diarrhea rate is reduced by 10 percent; the number of lymphocytes, mast cells and goblet cells in jejunal cells is respectively increased by 8.30%, 11.53% and 19.60%; the ratio of villus height to crypt depth of duodenum, jejunum and ileum is respectively improved by 10.57 percent, 13.40 percent and 9.27 percent; the content of Malondialdehyde (MDA) in intestinal mucosa has no difference, and the activity of super SOD and CAT is respectively improved by 9.05 percent and 17.01 percent.
In a word, the results show that the composite plant polyphenol chelate has the functions of improving the small intestine mucous membrane structure of piglets, enhancing the oxidation resistance of intestinal tracts and increasing the number of immune cells of the intestinal tract mucous membrane, and is superior to the action of antibiotics, so that the composite plant polyphenol chelate can replace the antibiotics to promote the intestinal tract immunity and the oxidation resistance in piglet feed, thereby improving the productivity of the piglets.
Example 4:
according to the mass ratio of baicalin copper, 4' -butyrylpuerarin and zinc tannate of 1: 5: and 4, combining, and uniformly mixing the compound to obtain the compound plant polyphenol chelate.
Simultaneously, 1 part of 75% baicalin is dissolved in 1 part of copper chloride aqueous solution containing 8.5% of copper, and the mixture is obtained after drying at 65 ℃; secondly, drying 1 part of 85% puerarin and 1 part of aqueous solution containing 8% butyric acid at 65 ℃ to obtain a second mixture; then drying 1 part of 80% tannic acid and 1 part of zinc chloride aqueous solution containing 6% at 65 ℃ to obtain a third mixture; and finally, mixing the three compounds according to the mass ratio of 1: 5: 4, obtaining a mixture (hereinafter referred to as mixture) with consistent composition of the composite plant polyphenol chelate of the example.
Broiler feeding test was conducted with the complex plant polyphenol chelate of this example. The same batch of 817 hatched chicks 360, divided into 3 groups of 8 replicates (columns) per group, 15 per column. The nutritional levels of the three groups of basic diets were consistent, wherein the feed contained aflatoxin at 500 μ g/kg, the blank control group contained no composite plant polyphenol chelate and mixture of the present invention, test group I contained 0.04% of the mixture of the composite plant polyphenol chelate of this example, and test group II contained 0.04% of the composite plant polyphenol chelate of this example. Raising for 35 days. The results are shown in tables 7, 8 and 9.
TABLE 7 Effect of adding Complex plant Polyphenol chelate on broiler growth Performance
Table 8 influence of adding composite plant polyphenol chelate on oxidation resistance of intestinal mucosa of broiler chicken and SlgA expression level
TABLE 9 influence of the addition of Complex plant Polyphenol chelate on the height of the feather/depth of crypt in the Small intestine of broiler chickens
The results show that when the daily ration contains 500 mug/kg of aflatoxin, compared with a blank control group, the daily gain and feed intake of the broiler are respectively improved by 20.35 percent and 15.95 percent, and the feed weight ratio is reduced by 3.59 percent by applying the composite plant polyphenol chelate disclosed by the invention; the ratio of villus height to crypt depth of duodenum and jejunum ileum is respectively improved by 44.95 percent and 38.14 percent; the content of Malondialdehyde (MDA) in the jejunum mucosa is reduced by 49.35 percent, and the activity of super CAT is improved by 90.07 percent and the expression level of mucosa SlgA is improved by 33.35 percent. Compared with a test group II fed with a mixture with the same composition of the composite plant polyphenol chelate, the daily gain and the feed intake of the broilers are respectively improved by 9.52 percent and 7.38 percent, and the feed weight ratio is reduced by 2.08 percent; the ratio of the villus height to the crypt depth of the duodenum and jejunum ileum is respectively improved by 30.57 percent and 24.43 percent; the content of Malondialdehyde (MDA) in the jejunum mucosa is reduced by 30.49%, and the activity of super CAT is improved by 35.31% and the expression level of mucosa SlgA is improved by 18.92%.
In a word, the results show that the composite plant polyphenol chelate of the embodiment has the effects of improving the small intestinal mucosa structure of the broiler chicken, enhancing the oxidation resistance of the intestinal tract and increasing the SIgA expression quantity of the intestinal mucosa, thereby improving the production performance of the broiler chicken, and the effect is better than that of a mixture with the same composition as that of the composite plant polyphenol chelate of the embodiment.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the equivalent replacement or change according to the technical solution and the modified concept of the present invention should be covered by the scope of the present invention.
Claims (8)
1. The composite plant polyphenol chelate is characterized by comprising baicalin copper, 4' -butyryl puerarin and zinc tannate, wherein the mass ratio of the raw materials is 1: 3-5: 4 to 6.
2. The complex plant polyphenol chelate of claim 1, wherein: the copper baicalin is a product prepared from baicalein-7-O-BETA-D-glucuronide and copper chloride in a methanol medium, wherein the content of the baicalein is at least 75%, and the content of the copper is 8.5-9.0%.
3. The complex plant polyphenol chelate of claim 2, wherein: the preparation method of the baicalin copper comprises the following steps: baicalein-7-O-BETA-D-glucuronide is obtained from scutellaria baicalensis, baicalein-7-O-BETA-D-glucuronide and copper chloride are reacted for 3 hours in a methanol solution at 50 ℃ according to the mass ratio of 2:1 to obtain dregs, and filter residues are dried at low temperature to obtain baicalin copper.
4. A composite plant polyphenol chelate according to claim 1, characterized in that: the 4 '-butyryl puerarin is a product prepared from 8-beta-D-glucopyranose-4', 7-dihydroxy isoflavone and butyryl chloride in acetone and sodium hydroxide medium, wherein the puerarin content is at least 85%, and the butyric acid content is 7.8-8.2%.
5. The complex plant polyphenol chelate of claim 4, wherein: the preparation method of the 4' -butyrylpuerarin comprises the following steps: preparing 8-beta-D-glucopyranose-4', 7-dihydroxyisoflavone from wild radix puerariae according to the mass ratio of 1.5: 1 weighing 8-beta-D-glucopyranose-4 ', 7-dihydroxyisoflavone and butyryl chloride, respectively dissolving in saturated sodium hydroxide solution and acetone solution with equal volume, uniformly mixing the two solutions, reacting for 2.5h at 20 ℃, and separating and filtering to obtain 4' -butyryl puerarin.
6. The complex plant polyphenol chelate of claim 1, wherein: the zinc tannate is a product prepared from tannic acid and zinc chloride in a methanol medium, wherein the content of tannic acid is at least 80%, and the content of zinc is 6.0-7.0%.
7. The complex plant polyphenol chelate of claim 6, wherein: the preparation method of the zinc tannate comprises the following steps: obtaining tannic acid from gallnut, wherein the tannic acid and zinc chloride are mixed according to a mass ratio of 1: 1.5 reacting in 45 ℃ ethanol solution for 2h, and spray drying to obtain zinc tannate.
8. A use method of a composite plant polyphenol chelate is characterized in that: adding the composite plant polyphenol chelate into livestock and poultry feed or drinking water according to the weight of 0.01-0.05% for use; mixing the composite plant polyphenol chelate with water for direct drinking; the compound plant polyphenol chelate is mixed with a carrier to prepare a premix, or the compound plant polyphenol chelate is mixed with a feed additive and feed raw materials to prepare a premix and a concentrated feed to feed the livestock and poultry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210347360.3A CN114642241B (en) | 2022-04-01 | 2022-04-01 | Composite plant polyphenol chelate and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210347360.3A CN114642241B (en) | 2022-04-01 | 2022-04-01 | Composite plant polyphenol chelate and application method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114642241A true CN114642241A (en) | 2022-06-21 |
| CN114642241B CN114642241B (en) | 2024-01-26 |
Family
ID=81995663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210347360.3A Active CN114642241B (en) | 2022-04-01 | 2022-04-01 | Composite plant polyphenol chelate and application method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114642241B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115813882A (en) * | 2022-12-06 | 2023-03-21 | 成都市丸天科技有限责任公司 | A method for enhancing absorption of vitamins and minerals in intestinal tract |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7455851B1 (en) * | 1999-06-25 | 2008-11-25 | Arch Chemicals, Inc. | Pyrithione biocides enhanced by silver, copper, or zinc ions |
| CN101703151A (en) * | 2009-06-18 | 2010-05-12 | 北京华牧伟业科技有限公司 | Application of coordination compound of flavone and trace elements to feedstuff industry |
| CN102106481A (en) * | 2011-01-11 | 2011-06-29 | 中国科学院亚热带农业生态研究所 | Method for preparing tannin chelate zinc feed additive |
| CN112314780A (en) * | 2020-11-25 | 2021-02-05 | 天津邦元生物科技有限公司 | Reinforcing agent for regulating and controlling intestinal health of livestock and poultry and preparation method thereof |
| US20210353583A1 (en) * | 2020-05-14 | 2021-11-18 | Probioticsmart, LLC | Tetrahydrocurcuminoid-metal complexes, manufacturing methods thereof, and uses thereof |
-
2022
- 2022-04-01 CN CN202210347360.3A patent/CN114642241B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7455851B1 (en) * | 1999-06-25 | 2008-11-25 | Arch Chemicals, Inc. | Pyrithione biocides enhanced by silver, copper, or zinc ions |
| CN101703151A (en) * | 2009-06-18 | 2010-05-12 | 北京华牧伟业科技有限公司 | Application of coordination compound of flavone and trace elements to feedstuff industry |
| CN102106481A (en) * | 2011-01-11 | 2011-06-29 | 中国科学院亚热带农业生态研究所 | Method for preparing tannin chelate zinc feed additive |
| US20210353583A1 (en) * | 2020-05-14 | 2021-11-18 | Probioticsmart, LLC | Tetrahydrocurcuminoid-metal complexes, manufacturing methods thereof, and uses thereof |
| CN112314780A (en) * | 2020-11-25 | 2021-02-05 | 天津邦元生物科技有限公司 | Reinforcing agent for regulating and controlling intestinal health of livestock and poultry and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| R. SÁNCHEZ-VIOQUEA: "Polyphenol composition and antioxidant and metal chelatingactivities of the solid residues from the essential oil industry", 《INDUSTRIAL CROPS AND PRODUCTS》, pages 150 - 159 * |
| 中国人民共和国国家质量监督检验检疫总局: "真菌毒素", 《GB13078-2017》, pages 4 * |
| 宋彬彬: "黄曲霉毒素及其分析方法", 《养殖技术顾问》, no. 7, pages 80 * |
| 张彬;向纪明;: "葛根素结构修饰的研究进展", 安康学院学报, no. 05, pages 99 - 103 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115813882A (en) * | 2022-12-06 | 2023-03-21 | 成都市丸天科技有限责任公司 | A method for enhancing absorption of vitamins and minerals in intestinal tract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114642241B (en) | 2024-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112189763A (en) | Preparation process and application of plant essential oil microcapsule | |
| CN103549222A (en) | Compound feed additive for preventing piglet diarrhea and preparation method thereof | |
| CN114642241B (en) | Composite plant polyphenol chelate and application method thereof | |
| CN108837006A (en) | A kind of macleaya cordata leaf extract and preparation method thereof and product | |
| CN111000033A (en) | Bacillus subtilis viable bacteria fermented traditional Chinese medicine preparation containing thyme oil and traditional Chinese medicine, preparation process and application | |
| CN113397041A (en) | Application of flood dragon wood in livestock breeding | |
| CN108308431B (en) | Pig feed additive containing riboflavin fermentation waste liquid and preparation method thereof | |
| CN110755604A (en) | Pharmaceutical composition for preventing and treating poultry adenofibromyositis and application thereof | |
| CN107789394B (en) | Composition for treating livestock and poultry diarrhea | |
| CN117244037B (en) | Composition for preventing and treating calf transfer transportation stress and preparation method thereof | |
| CN116549534B (en) | Pharmaceutical composition for promoting growth of egg chicks and regulating intestinal functions | |
| CN116270887B (en) | Chinese medicinal composition for chicken and preparation method thereof | |
| CN114588206B (en) | Preparation for treating yellow and white scour of piglets by dark plum combined with mequindox and preparation method of preparation | |
| CN114053330A (en) | Traditional Chinese medicine preparation for treating chicken salpingitis and enteritis as well as preparation method and application thereof | |
| KR20030021298A (en) | The composition of immune enhancer and intestinal regulator for animal | |
| CN109481491B (en) | Myrobalan composition and application thereof in preparation of products for preventing and/or treating porcine respiratory diseases | |
| CN109731044B (en) | Traditional Chinese medicine compound granule for treating intestinal infection of poultry and preparation method thereof | |
| CN107961284B (en) | Oral preparation for preventing and treating piglet diarrhea and preparation method thereof | |
| CN118020870A (en) | Feed additive for preventing lamb diarrhea and application method thereof | |
| CN112972545A (en) | Composition for preventing and treating enterogastritis of livestock and poultry | |
| WO2013015557A2 (en) | Feed composition including a mugwort extract for promoting animal growth | |
| CN117379500A (en) | Traditional Chinese medicine composition for treating chicken eimeria tenella and application thereof | |
| CN114680233A (en) | Application of cinnamaldehyde in preparing feed, feed additive, veterinary drug or water-drinking preparation for preventing or treating poultry adenoid myogastritis | |
| CN111066975A (en) | Feed additive for treating diarrhea of broiler chicken and preparation method thereof | |
| CN112088981A (en) | Fish feed for preventing and treating morbidity of fish seedlings for giant salamander culture and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |