CN112972545A

CN112972545A - Composition for preventing and treating enterogastritis of livestock and poultry

Info

Publication number: CN112972545A
Application number: CN202110268421.2A
Authority: CN
Inventors: 杜红娜; 仝文科; 朱明月; 张延华; 吉建伟; 马庆杰; 秦恒; 付炳尧; 杨景; 孔素叶; 苑军辉
Original assignee: Zhongnong Lingxiang Hebei Biotechnology Co ltd
Current assignee: Zhongnong Lingxiang Hebei Biotechnology Co ltd
Priority date: 2021-03-12
Filing date: 2021-03-12
Publication date: 2021-06-18

Abstract

The invention discloses a composition for preventing and treating enterogastritis of livestock and poultry, belonging to the field of veterinary use. The raw materials consist of the following substances in parts by weight: 20-35 parts of weathered coal, 1-8 parts of sage, 1-8 parts of hairyvein agrimony, 1-7 parts of humifuse euphorbia herb, 1-10 parts of poplar flower and 1-10 parts of sodium sulfate. The composition has the effects of relieving pain and diminishing inflammation, astringing and diminishing swelling and repairing mucosa, has a good treatment effect on diarrhea and gastrointestinal mucosa abscission, and can be used for preventing and treating early enteritis enterotoxin and gastritis. In addition, the composition also has the effects of promoting digestion and improving the utilization rate of the feed, and can be used by livestock and poultry in the whole process.

Description

Composition for preventing and treating enterogastritis of livestock and poultry

Technical Field

The invention belongs to the field of veterinary use, and particularly relates to a fulvic acid-containing composition for preventing and treating enterogastritis of livestock and poultry.

Background

The high and stable yield of the livestock and the poultry is guaranteed for obtaining high yield in the cultivation, but the yield of the livestock and the poultry is reduced due to diseases, poor feeding management, improper medication and the like in the actual cultivation process, so that the income of a culturist is directly reduced, and the harm factor of the diseases is the largest. Gastroenteritis refers to inflammatory changes of gastrointestinal mucosa caused by various factors, and is divided into acute and chronic according to the course of disease, with chronic diseases being common. The enterogastritis is caused by a plurality of factors, such as viral infection, bacterial infection, mycotoxin infection, environmental factors and the like. Such as proventriculitis, muscular gastritis, bacterial enteritis, viral enteritis, gastrointestinal tract infection caused by mycotoxin and the like which are popular at present in poultry; porcine viral diarrhea such as epidemic diarrhea, transmissible gastroenteritis, etc., greater dysentery of piglets, yellow scour, white scour, dysentery of piglets caused by bacterial infection, gastrointestinal inflammation caused by mycotoxin, etc.; gastroenteritis of fur-bearing animals caused by Escherichia coli, Salmonella, Pasteurella, etc. The clinical manifestations of enterogastritis of livestock and poultry can be seen in depression of spirit, loss of appetite, eyeball subsidence, body temperature rise, rapid and weak pulse, dry mouth and halitosis, abdominal pain and diarrhea, foul smell of feces, and yellowish white or bluish white tongue coating.

At present, the enterogastritis of livestock and poultry becomes an important disease for restricting the development of the breeding industry. Gastroenteritis is generally treated by western medicines, but the western medicines have large irritation and are easy to repeat, and can not treat both symptoms and root causes.

Disclosure of Invention

Aiming at the technical problems in the prior art, the invention provides a composition for preventing and treating enterogastritis of livestock and poultry and a preparation method thereof. In addition, the composition also has the effects of promoting digestion and improving the utilization rate of the feed, and can be used by livestock and poultry in the whole process.

The composition for preventing and treating enterogastritis of livestock and poultry comprises the following raw materials in parts by weight: 20-35 parts of weathered coal, 1-8 parts of sage, 1-8 parts of hairyvein agrimony, 1-7 parts of humifuse euphorbia herb, 1-10 parts of poplar flower and 1-10 parts of sodium sulfate.

The preferable raw materials comprise the following substances in parts by weight: 23-30 parts of weathered coal, 2-6 parts of sage, 2-6 parts of hairyvein agrimony, 1-5 parts of humifuse euphorbia herb, 2-8 parts of poplar flower and 2-8 parts of sodium sulfate.

The preferable raw materials comprise the following substances in parts by weight: 25-28 parts of weathered coal, 3-5 parts of sage, 3-5 parts of hairyvein agrimony, 2-4 parts of humifuse euphorbia herb, 4-7 parts of poplar flower and 4-7 parts of sodium sulfate.

The preferable composition for preventing and treating the enterogastritis of the livestock and the poultry comprises the following raw materials in parts by weight: 30 parts of weathered coal, 2 parts of sage, 6 parts of hairyvein agrimony, 2 parts of humifuse euphorbia herb, 6 parts of poplar flower and 3 parts of sodium sulfate.

The preferable composition for preventing and treating the enterogastritis of the livestock and the poultry comprises the following raw materials in parts by weight: 23 parts of weathered coal, 6 parts of salvia, 3 parts of hairyvein agrimony, 5 parts of humifuse euphorbia herb, 2 parts of poplar flower and 7 parts of sodium sulfate.

The preferable composition for preventing and treating the enterogastritis of the livestock and the poultry comprises the following raw materials in parts by weight: 27 parts of weathered coal, 4 parts of sage, 4 parts of hairyvein agrimony, 3 parts of humifuse euphorbia herb, 5 parts of poplar flower and 5 parts of sodium sulfate.

The weathered coal contains fulvic acid, which is also called fulvic acid and fulvic acid, is a substance extracted from low-grade coal (peat, brown coal and weathered coal), has low molecular weight, is brownish black or brownish brown in appearance, can be dissolved in acid, alkali, ethanol and water, and is a compound of substances with similar molecular structure and behavior characteristics.

Sage: bitter, slightly cold and nontoxic; clearing away heat, promoting diuresis, promoting blood circulation, regulating menstruation, removing toxic substance, and relieving swelling. It is mainly used for treating cold and heat in fistula of mice, dysentery with purulent blood.

Agrimony: bitter, astringent and mild in taste; has effects in astringing, stopping bleeding, stopping malaria, relieving dysentery, removing toxic substances, and tonifying deficiency; it can be used for treating hemoptysis, hematemesis, metrorrhagia, malaria, dysentery with bloody stool, carbuncle, suppurative sore, and strain.

Humifuse euphorbia herb: pungent taste and mild nature; has effects of clearing away heat and toxic materials, cooling blood, stopping bleeding, promoting diuresis, and eliminating jaundice; can be used for treating dysentery, diarrhea, hemoptysis, hematuria, hematochezia, metrorrhagia, furuncle, carbuncle, swelling, and jaundice due to damp-heat pathogen.

Poplar flower: bitter taste and cold nature; has effects of clearing away heat and toxic materials, eliminating dampness, and relieving dysentery; it can be used for treating bacillary dysentery and enteritis.

The preparation method of the composition for preventing and treating the gastroenteritis of the livestock and the poultry comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 7-11 at the extraction temperature of 65-85 ℃ for 1 hour in a single-stage extraction time, wherein the liquid ratio is 6 (the weight ratio of the alkaline water to the (weathered coal and poplar flower) is 6), the extraction stages are 2 times, and combining the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae according to a certain proportion, adding water 7 times of the total weight of the three Chinese medicinal materials, dynamically reflux-extracting for 2 times, each for 1 hr, mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating at 65-75 ℃ under reduced pressure, concentrating the extracting solution obtained by each kilogram of the total weight of the raw materials to 3L, and cooling to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.

The invention takes weathered coal as the center, and a large amount of extraction process research and clinical verification tests are carried out on the compounded traditional Chinese medicine, and the results show that: the mineral fulvic acid extracted from the weathered coal in the composition can quickly relieve pain, repair damaged mucosa, and be extracted together with poplar flower, so that the dissolution of active ingredients can be promoted, and the synergistic effect is obviously superior to the combined extraction of the weathered coal and other residual traditional Chinese medicines (one or more of sage, hairyvein agrimony, poplar flower and humifuse euphorbia herb) by means of separate extraction of the weathered coal; the salvia officinalis is antibacterial, the humifuse euphorbia herb is capable of clearing heat and removing toxicity, cooling blood and stopping bleeding, the hairyvein agrimony is capable of tonifying deficiency and enhancing the immunity of the organism, the three medicines are compatible and synergistic, the antibacterial and anti-inflammatory effects are achieved, the symptoms of enteritis and diarrhea can be improved, the organism constitution under the disease state is improved through the deficiency tonifying mode, and the efficacy of preventing and treating dysentery and enteritis is achieved to the utmost extent; in addition, the process of alkali extraction and acid precipitation retains the effective components to the maximum extent and ensures the stability of a solution system. Through a plurality of experimental researches, the formula and the process of the invention are finally determined.

The composition has four effects in livestock and poultry breeding

1. Promoting the activation and absorption of feed ingredients: various complex molecular nutrient components in the feed are fully decomposed and well organically combined, and the gastrointestinal function is increased; the feed nutrients can slowly pass through the intestinal tract, the absorption and digestion time is prolonged, and the absorption rate of the nutrient components is improved; the feed is rich in nitrogen elements and has stronger absorption effect on amino groups, so that non-protein amide in the feed is fully utilized, the feed protein is converted into muscle protein to a higher extent, the growth potential of the lean meat is exerted, and the specific gravity of the lean meat is improved; can improve gastrointestinal function, promote gastric secretion, stimulate appetite, promote nutrient substances to enter organism more quickly, and stimulate growth of beneficial bacteria in gastrointestinal tract.

2. Anti-inflammatory and analgesic

The composition can inhibit secretion of prostaglandin E2 (PGE 2, mediator of body inflammation and pain, inducing inflammation, and increasing pain sensitivity); activating the pituitary system, promoting the release of corticotropin and adrenocorticotropin (ACTH, having anti-inflammatory action), and counteracting the increase in capillary permeability caused by histamine; the composition is a polymer complex, and has strong adsorption capacity on inflammatory substances and toxic substances, so that inflammatory reaction and pain are greatly relieved. Can relieve the injury of general infection or septicemia caused by Escherichia coli and Salmonella to organism, relieve joint swelling and pain caused by Mycoplasma synoviae, and relieve gastrointestinal mucosa injury caused by myoglandular gastritis, coccidiosis, and Taenia.

3. Antiulcer and promoting wound healing: the composition can adsorb ulcer surface metal ions and poison, reduce pus odor and secretion, quickly form a protective film on wound surface, and contract blood capillary to stop bleeding; because the molecular structure determines that the compound is not only an oxidant but also a reducing agent, nascent oxygen can be separated, the internal respiration of cells is increased, the metabolism of the cells is promoted, the survival of fibroblasts and the growth of granulation tissues are facilitated, and the infection is effectively controlled; the structure contains various active groups, so that the composition can contract blood vessels, reduce capillary permeability, stimulate mucous membranes, increase blood flow of the mucous membranes, reverse abnormal microcirculation perfusion and promote the mucous membranes to recover to normal.

Microorganisms such as escherichia coli, salmonella, mould, coccidium and the like invade the body, infected body cells are stimulated and damaged by the microorganisms, local cells are subjected to hypoxia to cause necrosis, harmful ions and toxic substances are separated, the toxic products damage the health, and the wound surface is enlarged. The composition has analgesic, inflammatory mediator exudation reducing, inflammatory substance adsorbing, damaged mucosa repairing, organism injury caused by Escherichia coli, Salmonella, mold, coccidium resisting, and organism rehabilitation promoting effects.

4. Effectively regulating the immune function: the composition can promote the development of animal immune organs (such as lymph node, thymus, spleen, and bursa of fabricius) and epithelial reticular cell, increase phagocyte number in animal blood, increase antibody content, enhance immunity, and improve animal nonspecific immunity.

The occurrence and elimination of diseases are the processes of animal fight against diseases, and the occurrence of diseases like bacteria, molds, viruses, parasites and mycoplasma is very important in relation to the immunity and resistance of the organism. The composition can regulate immunity, relieve injury of body caused by systemic infection or septicemia due to Escherichia coli and Salmonella, relieve damage of gastrointestinal mucosa due to bacteria, mold, parasite (coccidium and cestode), relieve joint damage due to Mycoplasma synoviae, relieve respiratory tract damage due to diseases such as Newcastle disease, avian influenza and infectious bursal disease caused by virus, and accelerate rehabilitation of patients.

Application effect of poultry, pig, cattle and sheep

First, poultry

The long-term application of the composition can avoid drug-induced and non-drug-induced immunosuppression, and prevent avian influenza. The composition has the advantages of preventing viral diseases, having obvious auxiliary treatment effect on fowl plague, greatly reducing the morbidity of coccidiosis, bursal disease, Newcastle disease and Marek's disease, reducing the phenomenon of pecking anus and feather, reducing the morbidity of respiratory tract infection by 75 percent and the infection of salmonella by 45 percent by long-term application, having obvious auxiliary treatment effect on infectious laryngotracheitis and bronchitis, reducing the occurrence of intestinal diseases, ensuring that the intestinal tract of a chicken is complete, the intestinal villus is thickened, the intestinal wall is thickened, reducing the diarrhea rate and improving the absorption rate of nutrient substances. The survival rate of the chicks is obviously improved. And can be used for preventing and treating feces, dirty eggs, broken eggs and soft shell eggs caused by salpingitis of egg-laying fowl.

1. The application of the composition in laying hens and ducks is as follows:

(1) the composition can improve the growth and development speed of chicks, improve the uniformity, obviously improve the average daily gain by 8.96-10.11 percent and obviously reduce the material-to-weight ratio by 8.05-12.12 percent; the specificity and non-specificity immunity of the chicks are improved, the bursal index is improved by 10.23-15.52%, the antibody titer of Newcastle disease and avian influenza is obviously improved by 5.23-7.21%, the survival rate of the chicks is 96-99.5%, and the survival rate of the adult chicks is as high as 99-100%.

(2) The composition can lead the egg laying to be advanced for 3-5 days, and the feed utilization rate is improved by 10-15%; blood analysis shows that the values of neutrophils, lymphocytes and Newcastle disease antibodies are respectively improved by 7.21-21.37%, 14.5-14.73% and 11.28-18.08%, and the peak maintenance time of the antibodies can be increased by 3-8 days.

(3) The composition can prolong the egg laying peak period (egg laying rate is more than 90%) by more than two months, increase the egg laying rate in the whole period by 12.4%, increase the feed utilization rate by 13.67%, increase the feed-egg ratio by 2.37: 1, and has obvious effect of recovering egg laying of the layer with infectious diseases.

(4) Can prevent and treat infectious laryngotracheitis, bronchitis, pullorum disease of chicken/duck, coccidiosis, colibacillus and salmonella, and has high survival rate of 5.67-15.42%, less medicine residue and high meat quality. (5) Can prolong the egg laying peak period by more than two months, increase the egg weight and the eggshell thickness, lead the yolk to be fresh yellow and the eggshell to be bright, reduce the sand preserved eggs and the soft-shelled eggs, improve the egg laying rate by 4.62 to 7.45 percent, reduce the feed-egg ratio by 2.07 to 3.97 percent and increase the egg weight by 0.27 to 1.21 percent.

(6) Can be used for preventing and treating feces, dirty eggs, broken eggs and soft shell eggs caused by salpingitis of egg-laying fowl. The proportion of the dung eggs, the dirty eggs, the broken eggs and the soft-shell eggs is reduced by 68.67 to 89.21 percent.

2. The application of the composition in broiler chickens and meat ducks is as follows: the weight gain speed is improved, the feeding period is shortened, the slaughtering is advanced, the average daily weight gain of the broilers is improved by 0.98-1.34%, and the feed-meat ratio is reduced by 2.07-2.35%. The weight gain per kilogram can save 0.15 kilogram of feed, and improve the feed utilization rate by 6.5 percent. Has no toxic or side effect, can not generate drug residues after long-term use, and has important significance for improving the quality of the broiler chickens and increasing the export. And secondly, 1, the daily gain of the pigs is improved (about 60 grams of the weight is increased), and the fattening pigs are fed to the slaughter (about 250 jin) to save 40-50 kilograms of feed, have bright fur, compact body and high lean meat percentage, are fragrant and not greasy in meat quality and can reach the pollution-free standard. 2. The composition has the advantages of promoting the development of immune organs, improving the immunity, enhancing the anti-stress capability, reducing the morbidity, improving the survival rate by 10 percent, having obvious effects of preventing the blue-ear disease, the unknown hyperpyrexia and the foot-and-mouth disease, basically controlling the occurrence of the pig digestive tract diseases after the composition is used, and reducing the mortality rate by 15 to 30 percent. 3. After the boar is used for a long time, the semen level of the boar is improved, the mating and parturition rate of the sow is improved, the lactation yield is improved, the fever and anorexia of the sow are greatly reduced, and the postpartum weight of the sow is quickly recovered; the incidence of mastitis, endometritis and lactation disorder syndrome is reduced by 8 to 12 percent; the birth weight and the weaning weight of the piglets are improved, and the survival rate can reach more than 95 percent. 4. Can promote the secretion of digestive enzyme, activate the digestive enzyme, promote the adaptation to plant feed after early weaning of young animals, promote the digestive absorption, prevent diseases such as gastroenteritis, dysentery and the like of piglets, and reduce the diarrhea incidence by 5 to 8 percent. 5. After the composition is used, the composition can deodorize, thereby reducing environmental pollution. Thirdly, cattle and sheep 1, the product promotes the secretion of digestive enzyme, activates the digestive enzyme, promotes the adaptation to plant feed after early weaning of young animals, promotes the digestion and absorption, promotes the growth, and improves the utilization rate of the feed by more than 20%;

2. the disease resistance is improved, digestive tract diseases such as gastroenteritis, dysentery and the like of cattle and sheep and the occurrence of various infectious diseases are effectively prevented, and the death and culling rate is reduced by 35-50%. Meanwhile, the composition has the repairing effect on mucosal tissues, can reduce the damage of toxin to gastrointestinal cell walls, and slows down the entrance of endotoxin into cells and blood. And has the functions of preventing wound infection and promoting healing;

3. the immunity of the organism is enhanced, the incidence of recessive mastitis, endometritis, mastitis and endometritis is effectively controlled to be reduced by 15-30%, the special effect of adjuvant therapy of the mastitis is achieved, the milk is reduced less, and the alcohol positive milk can be prevented after long-term application.

4. Improving the anti-stress capability, and not reducing the milk or reducing the milk less in the material changing, group transferring, vaccine inoculation, continuous high temperature and high cold season. 5. The perinatal feeding can prevent fetus from melting and dying, reduce the fetus dying rate by 30 to 50 percent, ensure that the postpartum mother animals have more and thick milk, and effectively prevent the phenomena of mastitis, antenatal and postpartum paralysis, insufficient milk and the like. The produced young children have uniform and strong heads and can not get ill or get ill rarely. The composition can be used by milk cow for a long time, and can increase daily milk yield by 0.5-1.5 kg, and significantly increase the milk fat rate and milk protein. 6. The rumen pH value is stabilized, the propagation of rumen microflora is promoted, the balance of gastrointestinal flora is kept, the appetite is enhanced, the true stomach incidence rate is 0, the forestomach disease incidence rate is 0.3 percent, the enteritis incidence rate is 0.2 percent, the effect on viral diarrhea is particularly obvious after long-term application, and the diarrhea incidence rate can be reduced by 70 to 80 percent. 7. Solves the problem of antibiotic residue in milk and goat milk, reduces the quantity of antibiotic milk, and increases the proportion of fresh milk on the market.

The composition of the invention has synergistic effect when used together with other medicines

1. The compound is used together with escherichia coli medicines: the composition has effects of relieving inflammation and pain, repairing damaged intestinal mucosa, remarkably relieving injury to organism caused by systemic infection or septicemia caused by Escherichia coli and salmonella, and accelerating disease recovery;

2. the composition is used together with a medicine for treating the myoglandular gastritis: the composition has effects of relieving inflammation and pain, repairing damaged gastric mucosa, rapidly increasing livestock and fowl feed intake, reducing injury of pathogenic factors to organism, and accelerating recovery of disease;

3. the compound is used together with antiviral drugs: the composition has effects in enhancing immunity, resisting virus, improving synergistic effect, and promoting recovery of disease.

Description of the drawings:

FIG. 1 is a photograph of feces from poultry prior to use of the composition of the present invention

FIG. 2 is a photograph of feces of poultry treated with the composition of the present invention

FIG. 3 is a photograph of an egg prior to use of the composition of the present invention in a poultry health test-A photograph of an egg

FIG. 4 is a photograph of an egg prior to use of the composition of the present invention in a poultry health test

FIG. 5 is a photograph of eggs from a poultry health test using a composition of the present invention

The invention has the beneficial effects that:

the composition has the effects of relieving pain and diminishing inflammation, astringing and diminishing swelling and repairing mucosa, has a good treatment effect on diarrhea and gastrointestinal mucosa abscission, and can be used for preventing and treating early enteritis enterotoxin and gastritis. In addition, the composition also has the effects of promoting digestion and improving the utilization rate of the feed, and can be used by livestock and poultry in the whole process. The raw materials comprise weathered coal, sage, hairyvein agrimony, humifuse euphorbia herb, poplar flower and sodium sulfate. The composition is green, non-resistant, safe and effective, has no toxic or side effect on organisms, and can cater to the great trend of reducing resistance and limiting resistance in the livestock industry.

Detailed Description

The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.

Example 1

270g of weathered coal, 40g of salvia, 40g of hairyvein agrimony, 30g of humifuse euphorbia herb, 50g of poplar flower and 50g of sodium sulfate are taken for later use.

The preparation method comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 10 at the extraction temperature of 70 ℃, performing single-stage extraction for 1 hour at the liquid ratio of 6, performing extraction for 2 times, and mixing the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae at a certain ratio, adding 7 times of water, dynamically reflux-extracting for 2 times (each time for 1 hr), and mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating the mixture to 1.44L at 70 ℃ under reduced pressure, and cooling the mixture to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.

Example 2

230g of weathered coal, 60g of salvia, 30g of hairyvein agrimony, 50g of humifuse euphorbia herb, 20g of poplar flower and 70g of sodium sulfate for later use.

The preparation method comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 7 at the extraction temperature of 85 ℃ for 1 hour in a single-stage extraction time, performing liquid ratio of 6 for 2 times, and mixing the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae at a certain ratio, adding 7 times of water, dynamically reflux-extracting for 2 times (each time for 1 hr), and mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating the mixture to 1.38L at 65 ℃ under reduced pressure, and cooling the mixture to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.

Example 3

Taking 300g of weathered coal, 20g of salvia, 60g of hairyvein agrimony, 20g of humifuse euphorbia herb, 60g of poplar flower and 30g of sodium sulfate for later use.

The preparation method comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 11 at the extraction temperature of 65 ℃ for 1 hour in a single-stage extraction time, performing liquid ratio of 6, performing extraction for 2 times, and mixing the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae at a certain ratio, adding 7 times of water, dynamically reflux-extracting for 2 times (each time for 1 hr), and mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating the mixture at 75 ℃ under reduced pressure to 1.47L, and cooling the mixture to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.

Example 4

350g of weathered coal, 10g of salvia, 50g of hairyvein agrimony, 40g of humifuse euphorbia herb, 60g of poplar flower and 80g of sodium sulfate for later use.

The preparation method comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 11 at the extraction temperature of 75 ℃ for 1 hour in a single-stage extraction time, performing liquid ratio of 6 for 2 times, and mixing the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae at a certain ratio, adding 7 times of water, dynamically reflux-extracting for 2 times (each time for 1 hr), and mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating the mixture at 70 ℃ under reduced pressure to 1.77L, and cooling the mixture to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.

Examination of clinical Effect of the composition of example 1 of the present invention

Case 1, therapeutic test for diarrhea in poultry

Symptoms are: diarrhea in poultry (chicken).

Treatment: the composition of the invention is added with 5000 jin of water in 1L, and each adult chicken takes 0.1ml daily for 1 time each day.

The effect is as follows: the feces are obviously formed after two days of use, and the photograph of the feces before use is shown in figure 1, and the photograph of the feces after use is shown in figure 2.

Case 2 poultry health test

Background: 2500 chickens, soft shell eggs, shell-broken eggs 2.5 dishes per day.

The health care scheme is as follows: the composition of the invention is added with 5000 jin of water in 1L, and each adult chicken takes 0.1ml daily for 1 time every day for 7 days continuously.

The effect is as follows:

1. the number of "bad eggs" decreased from 2.5 to 1.5 plates per day;

2. the number of the white-shell proteins is obviously reduced;

3. the oil light brightening powder shell surpasses! The pictures of the eggs before use are shown in figures 3 and 4, and the pictures of the eggs after use are shown in figure 5.

Application test of the composition of example 1 of the invention to sheep

A place: tang county

1. Anti-stress newly introduced lamb intestine and stomach conditioning

The newly introduced lamb is 20 days, 40 ml of liquid medicine and 200 jin of water are added, the intestines and the stomach are conditioned in circles, and the excrement has obvious change (the excrement is gradually normal). The whole state is better than other rings which are not conditioned by using liquid medicine.

2. Treatment of newly purchased lamb diarrhea

About 15 kg of newly introduced lamb from inner Mongolia will cause diarrhea symptoms due to environmental changes. 5mL of the liquid medicine and 5mL of water are infused by a syringe, the medicine is taken 1 time a day, the dosage is obviously reduced after 2 times, and a small amount of food is taken.

Mild diarrhea: the medicine can be basically recovered for two times, and the medicine can be stopped for 4 times;

severe disease condition: when combined with other drugs, the composition can be obviously relieved for 2 times and recovered for 3 days.

And (3) comparison: the diarrhea condition of sheep with the same size in the same batch lasts for a long time, and the sheep are injured and killed by using a large amount of antibiotics.

3. Treatment of sheep diarrhea in fattening period

Symptoms are: diarrhea.

Treatment: the medicine liquid is 10mL and water is 10mL, and the medicine liquid is infused by a syringe and taken 2 times a day.

The effect is as follows: after 2 times, there was a significant decrease and a small meal started.

Mild diarrhea: can recover basically 2 times, and stop taking medicine 4 times;

② severe cases: when combined with other drugs, the composition can be obviously relieved for 2 times and recovered for 3 days.

4. Regulating diarrhea, drying and leftover materials of sheep in fattening period

Six cycles (4, 7, 8, 9, 11 and 12) of sheep in the fattening period are provided, 50-70 sheep in each cycle are fed, the condition that the residual material exists in No. 7 cycles continuously twice is found during feeding, 40 ml of liquid medicine and 200 jin of water are added, the whole feeding is carried out for 2 times, the condition that the residual material does not exist any more, partial diarrhea exists, and the dried sheep manure is recovered to be normal. In the same condition, the No. 9 sheepfold also takes the same measures and has basically the same effect.

5. Sheep (newly purchased-slaughtered) whole course contrast test

Two raising households newly purchase 1400 sheep in the same batch from the inner Mongolia, the number of the sheep is divided into two, 700 sheep are raised for 140 days respectively in each house, and the sheep are slaughtered. One of the compositions of the present invention was used for health care, and one was used for conventional breeding, and comparative data are shown in table 1 below.

TABLE 1

Distinction between	Addition of the composition of the invention to the user	User is raised to conventional	Distance difference
				Total net profit (Wanyuan)	20.3 ten thousand	7.8 ten thousand yuan	12.5 ten thousand yuan
Average weight of sheep out of slaughter	56.7kg	51.1kg	5.6kg
				Average net profit per sheep	290 yuan/only	111 yuan/only	179 yuan/only
Sheep death and culling	0 is	40 pieces of	40 are

Application of composition of example 1 of the invention to treatment of piglet diarrhea

Symptoms are: diarrhea of piglets.

Treatment: 2 ml liquid medicine/head, the syringe is drenched once a day for 3 days continuously.

The effect is as follows:

mild diarrhea: can recover basically 2 times, and stop taking medicine 3 times;

Claims

1. The composition for preventing and treating enterogastritis of livestock and poultry is characterized by comprising the following components in parts by weight: the raw materials consist of the following substances in parts by weight: 20-35 parts of weathered coal, 1-8 parts of sage, 1-8 parts of hairyvein agrimony, 1-7 parts of humifuse euphorbia herb, 1-10 parts of poplar flower and 1-10 parts of sodium sulfate.

2. The composition for preventing and treating gastroenteritis of livestock and poultry according to claim 1, wherein the composition comprises the following components in percentage by weight: the raw materials consist of the following substances in parts by weight: 23-30 parts of weathered coal, 2-6 parts of sage, 2-6 parts of hairyvein agrimony, 1-5 parts of humifuse euphorbia herb, 2-8 parts of poplar flower and 2-8 parts of sodium sulfate.

3. The composition for preventing and treating gastroenteritis of livestock and poultry according to claim 2, wherein the composition comprises the following components in percentage by weight: the raw materials consist of the following substances in parts by weight: 30 parts of weathered coal, 2 parts of sage, 6 parts of hairyvein agrimony, 2 parts of humifuse euphorbia herb, 6 parts of poplar flower and 3 parts of sodium sulfate.

4. The composition for preventing and treating gastroenteritis of livestock and poultry according to claim 2, wherein the composition comprises the following components in percentage by weight: the raw materials consist of the following substances in parts by weight: 23 parts of weathered coal, 6 parts of salvia, 3 parts of hairyvein agrimony, 5 parts of humifuse euphorbia herb, 2 parts of poplar flower and 7 parts of sodium sulfate.

5. The composition for preventing and treating gastroenteritis of livestock and poultry according to claim 2, wherein the composition comprises the following components in percentage by weight: the raw materials consist of the following substances in parts by weight: 27 parts of weathered coal, 4 parts of sage, 4 parts of hairyvein agrimony, 3 parts of humifuse euphorbia herb, 5 parts of poplar flower and 5 parts of sodium sulfate.

6. The preparation method of the composition for preventing and treating gastroenteritis of livestock and poultry according to claim 1 or 2, which is characterized by comprising the following steps: the method comprises the following steps: (1) weighing weathered coal and poplar flower according to a ratio, performing ultrasonic countercurrent extraction with alkaline water with the pH value of 7-11 at the extraction temperature of 65-85 ℃ for 1 hour in a single-stage extraction time, wherein the liquid ratio is 6, the extraction stages are 2 times, and combining the extracting solutions to obtain a solution 1; (2) weighing herba Salvia officinalis, herba et Gemma Agrimoniae, and herba Euphorbiae Humifusae according to a certain proportion, adding water 7 times of the total weight of the three Chinese medicinal materials, dynamically reflux-extracting for 2 times, each for 1 hr, mixing extractive solutions to obtain solution 2; (3) uniformly mixing the solution 1 and the solution 2, concentrating at 65-75 ℃ under reduced pressure, and cooling to room temperature to obtain a solution 3; (4) adding acid into the solution 3 to adjust the pH value to 2-4, decoloring by using activated carbon, and filtering to obtain a solution 4; (5) and taking the solution 4, adding sodium sulfate according to the proportion, and uniformly stirring to obtain a clear and transparent solution.