CN114599398A - 用gm-csf拮抗剂治疗癌症 - Google Patents

用gm-csf拮抗剂治疗癌症 Download PDF

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Publication number
CN114599398A
CN114599398A CN202080054412.7A CN202080054412A CN114599398A CN 114599398 A CN114599398 A CN 114599398A CN 202080054412 A CN202080054412 A CN 202080054412A CN 114599398 A CN114599398 A CN 114599398A
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China
Prior art keywords
antibody
cancer
csf
patient
antibodies
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CN202080054412.7A
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English (en)
Chinese (zh)
Inventor
N.鲁纳克
J.皮雷洛
E.特萨里
L.卡瓦贾尔
A.德安德里
F.穆塞
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Kiniksa Phamaceuticals Ltd
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Kiniksa Phamaceuticals Ltd
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Priority to CN202410532037.2A priority Critical patent/CN118949031A/zh
Publication of CN114599398A publication Critical patent/CN114599398A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202080054412.7A 2019-06-03 2020-06-03 用gm-csf拮抗剂治疗癌症 Pending CN114599398A (zh)

Priority Applications (1)

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CN202410532037.2A CN118949031A (zh) 2019-06-03 2020-06-03 用gm-csf拮抗剂治疗癌症

Applications Claiming Priority (3)

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US201962856638P 2019-06-03 2019-06-03
US62/856,638 2019-06-03
PCT/US2020/035957 WO2020247521A1 (en) 2019-06-03 2020-06-03 Treatment of cancers with gm-csf antagonists

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CN202410532037.2A Pending CN118949031A (zh) 2019-06-03 2020-06-03 用gm-csf拮抗剂治疗癌症

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US (1) US20220331425A1 (https=)
EP (1) EP3976080A1 (https=)
JP (2) JP2022535062A (https=)
KR (1) KR20220042067A (https=)
CN (2) CN114599398A (https=)
AU (1) AU2020287327A1 (https=)
WO (1) WO2020247521A1 (https=)

Cited By (1)

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CN116685352A (zh) * 2020-10-26 2023-09-01 基尼克萨制药有限公司 用gm-csf拮抗剂治疗癌症

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WO2022093855A1 (en) * 2020-10-26 2022-05-05 Kiniksa Pharmaceuticals, Ltd. Treatment of cancers with gm-csf antagonists
CN112813066A (zh) * 2021-01-22 2021-05-18 中国科学院微生物研究所 一种调控Treg细胞活化的方法
WO2023220128A1 (en) * 2022-05-10 2023-11-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Targeting myeloid-derived suppressor cells (mdscs) in bladder cancer to enhance efficacy of adoptive cell therapy (act)

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EP3976080A1 (en) 2022-04-06
US20220331425A1 (en) 2022-10-20
JP2025013608A (ja) 2025-01-24
CN118949031A (zh) 2024-11-15
WO2020247521A1 (en) 2020-12-10
AU2020287327A1 (en) 2022-03-10
JP2022535062A (ja) 2022-08-04
KR20220042067A (ko) 2022-04-04

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