CN114599370A - 用于保护软骨的药物组合物 - Google Patents

用于保护软骨的药物组合物 Download PDF

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Publication number
CN114599370A
CN114599370A CN202080073934.1A CN202080073934A CN114599370A CN 114599370 A CN114599370 A CN 114599370A CN 202080073934 A CN202080073934 A CN 202080073934A CN 114599370 A CN114599370 A CN 114599370A
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CN
China
Prior art keywords
ylazo
amino
naphthalene
pyridin
sulfonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202080073934.1A
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English (en)
Chinese (zh)
Inventor
西谷江平
垣塚彰
池田华子
松田秀一
岩井祥子
齐藤元央
武藏国弘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Chuangyao Research Institute
Kyoto University NUC
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Kyoto Chuangyao Research Institute
Kyoto University NUC
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Publication date
Application filed by Kyoto Chuangyao Research Institute, Kyoto University NUC filed Critical Kyoto Chuangyao Research Institute
Publication of CN114599370A publication Critical patent/CN114599370A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202080073934.1A 2019-10-24 2020-10-23 用于保护软骨的药物组合物 Pending CN114599370A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-193329 2019-10-24
JP2019193329 2019-10-24
PCT/JP2020/039896 WO2021079983A1 (ja) 2019-10-24 2020-10-23 軟骨保護用の医薬組成物

Publications (1)

Publication Number Publication Date
CN114599370A true CN114599370A (zh) 2022-06-07

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Family Applications (1)

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CN202080073934.1A Pending CN114599370A (zh) 2019-10-24 2020-10-23 用于保护软骨的药物组合物

Country Status (6)

Country Link
US (1) US20220401461A1 (https=)
EP (1) EP4049724A4 (https=)
JP (1) JPWO2021079983A1 (https=)
KR (1) KR20220087499A (https=)
CN (1) CN114599370A (https=)
WO (1) WO2021079983A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023120704A1 (ja) 2021-12-24 2023-06-29 国立大学法人京都大学 心機能を改善するための組成物
EP4628084A1 (en) * 2022-11-28 2025-10-08 Kyoto University Naphthalene-derivative-based therapeutic drug for ophthalmological disease

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101754965A (zh) * 2007-05-21 2010-06-23 诺瓦提斯公司 Csf-1r抑制剂、组合物及使用方法
US20110166180A1 (en) * 2008-07-25 2011-07-07 Hiroki Yokota Method for treatment of bone diseases and fractures
US20130184241A1 (en) * 2010-07-30 2013-07-18 Kyoto University Naphthalene Derivative
US20140148416A1 (en) * 2010-09-30 2014-05-29 Kyoto University Agent for Treatment of Eye Diseases
WO2014207241A1 (en) * 2013-06-28 2014-12-31 Alzprotect NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
CN105586389A (zh) * 2014-10-21 2016-05-18 天津华大基因科技有限公司 试剂盒及其在检测遗传性骨病基因中的用途
US20160303144A1 (en) * 2013-09-04 2016-10-20 Kyoto University Medicinal Composition Improving Leptin Resistance

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010038153A1 (en) * 2008-10-01 2010-04-08 The University Of British Columbia Use of sox transcription factor acti\ators for stimulating chondrogenesis
DK2959903T3 (en) 2013-02-20 2019-01-21 Univ Kyoto Medicine for the treatment of eye disease
WO2015129809A1 (ja) 2014-02-28 2015-09-03 国立大学法人京都大学 虚血性眼疾患の処置用の医薬組成物
ES2925638T3 (es) 2017-12-27 2022-10-19 Univ Kyoto Composición para la protección de la córnea
JP2019193329A (ja) 2018-04-18 2019-10-31 パナソニックＩｐマネジメント株式会社 平面モータシステム

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101754965A (zh) * 2007-05-21 2010-06-23 诺瓦提斯公司 Csf-1r抑制剂、组合物及使用方法
US20110166180A1 (en) * 2008-07-25 2011-07-07 Hiroki Yokota Method for treatment of bone diseases and fractures
US20130184241A1 (en) * 2010-07-30 2013-07-18 Kyoto University Naphthalene Derivative
US20140148416A1 (en) * 2010-09-30 2014-05-29 Kyoto University Agent for Treatment of Eye Diseases
WO2014207241A1 (en) * 2013-06-28 2014-12-31 Alzprotect NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
US20160303144A1 (en) * 2013-09-04 2016-10-20 Kyoto University Medicinal Composition Improving Leptin Resistance
CN105586389A (zh) * 2014-10-21 2016-05-18 天津华大基因科技有限公司 试剂盒及其在检测遗传性骨病基因中的用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MASAYUKI HATA: "KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress", SCIENTIFIC REPORTS, vol. 7, pages 1 - 10, XP055643336, DOI: 10.1038/srep44873 *
朱伟民;陆伟;韩云;周可;欧阳侃;彭亮权;冯文哲;李皓;何春耒;王大平;江捍平;: "慢性关节炎和正常大鼠软骨及滑膜基因表达的差异", 中国组织工程研究与临床康复, vol. 1993, no. 15, pages 10 - 11 *
龙新华: "miＲNA-129-5p 靶向调控VCP 基因在人骨肉瘤细胞中 表达初步探讨", 医学研究生学报, vol. 27, no. 7, pages 679 - 682 *

Also Published As

Publication number Publication date
JPWO2021079983A1 (https=) 2021-04-29
KR20220087499A (ko) 2022-06-24
US20220401461A1 (en) 2022-12-22
WO2021079983A1 (ja) 2021-04-29
EP4049724A4 (en) 2023-05-03
EP4049724A1 (en) 2022-08-31

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