CN114585316A - 骨结合化合物 - Google Patents

骨结合化合物 Download PDF

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Publication number
CN114585316A
CN114585316A CN202080066011.3A CN202080066011A CN114585316A CN 114585316 A CN114585316 A CN 114585316A CN 202080066011 A CN202080066011 A CN 202080066011A CN 114585316 A CN114585316 A CN 114585316A
Authority
CN
China
Prior art keywords
compound
csa
subject
pharmaceutical composition
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080066011.3A
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English (en)
Chinese (zh)
Inventor
保罗·B·萨维奇
亚伦·辛德勒
彼得·瓦尔切夫
苏迈德·坎布尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham Young University filed Critical Brigham Young University
Publication of CN114585316A publication Critical patent/CN114585316A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug one of the codrug's components being an antibiotic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00889—Material properties antimicrobial, disinfectant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN202080066011.3A 2019-07-24 2020-07-24 骨结合化合物 Pending CN114585316A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962878199P 2019-07-24 2019-07-24
US62/878,199 2019-07-24
PCT/US2020/043563 WO2021016583A1 (en) 2019-07-24 2020-07-24 Bone-binding compounds

Publications (1)

Publication Number Publication Date
CN114585316A true CN114585316A (zh) 2022-06-03

Family

ID=74194302

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080066011.3A Pending CN114585316A (zh) 2019-07-24 2020-07-24 骨结合化合物

Country Status (8)

Country Link
US (1) US20220273673A1 (https=)
EP (1) EP4003201A4 (https=)
JP (1) JP7580815B2 (https=)
KR (1) KR20220041152A (https=)
CN (1) CN114585316A (https=)
AU (1) AU2020319089A1 (https=)
CA (1) CA3145403A1 (https=)
WO (1) WO2021016583A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12215126B2 (en) 2020-05-21 2025-02-04 Brigham Young University Cationic steroidal antimicrobial compounds with endogenous groups
WO2023064802A1 (en) * 2021-10-13 2023-04-20 The Trustees Of Columbia University In The City Of New York Methods for controlling osteocalcin release
US20250073248A1 (en) * 2023-09-05 2025-03-06 Brigham Young University Bioresorbable cationic steroidal antimicrobial compounds with glyceride linkages

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271761A1 (en) * 2011-08-25 2014-09-18 Brigham Young University Incorporation of particulate ceragenins in polymers
CN104080459A (zh) * 2011-09-13 2014-10-01 布莱阿姆青年大学 用于治疗骨疾病和断骨的组合物
US20150366880A1 (en) * 2011-09-13 2015-12-24 Brigham Young University Compositions and methods for treating bone diseases and broken bones
US20160095932A1 (en) * 1998-04-02 2016-04-07 Mbc Pharma, Inc. Bone Targeted Therapeutics and Methods of Making and Using the Same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926081B1 (fr) 2008-01-03 2010-02-19 Univ Nantes Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux
EP2303288A4 (en) * 2008-05-22 2015-04-22 Univ Ramot CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESE MEDIUM AND ITS USE IN THE TREATMENT AND CONTROL OF ILLNESSES RELATED TO BONE
FR2973378B1 (fr) 2011-03-28 2013-10-04 Atlanthera Derives d'acide hydroxybisphosphonique bifonctionnels
CN104147614B (zh) * 2013-05-15 2016-08-24 深圳先进技术研究院 一种阿伦膦酸功能化的聚乙二醇修饰的纳米颗粒及其制备方法
US9931350B2 (en) * 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
WO2015168636A1 (en) 2014-05-02 2015-11-05 The Regents Of The University Of California Bone-selective osteogenic oxysterol bisphosphonate analogs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160095932A1 (en) * 1998-04-02 2016-04-07 Mbc Pharma, Inc. Bone Targeted Therapeutics and Methods of Making and Using the Same
US20140271761A1 (en) * 2011-08-25 2014-09-18 Brigham Young University Incorporation of particulate ceragenins in polymers
CN104080459A (zh) * 2011-09-13 2014-10-01 布莱阿姆青年大学 用于治疗骨疾病和断骨的组合物
US20150366880A1 (en) * 2011-09-13 2015-12-24 Brigham Young University Compositions and methods for treating bone diseases and broken bones

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OLGA BORTOLINI: "Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》, vol. 52, 19 March 2012 (2012-03-19), pages 221 - 229, XP028420651, DOI: 10.1016/j.ejmech.2012.03.020 *
REBECCA MILLS BMBCH: "CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model", 《CLINICAL ORTHOPAEDICS AND RELATED RESEARCH》, vol. 476, 26 April 2018 (2018-04-26), pages 1311 - 1323, XP093061425, DOI: 10.1097/01.blo.0000533624.79802.e1 *
TOM J. HOUGHTON: "Linking Bisphosphonates to the Free Amino Groups in Fluoroquinolones: Preparation of Osteotropic Prodrugs for the Prevention of Osteomyelitis", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 51, no. 21, 4 October 2008 (2008-10-04), pages 6955 - 6969, XP055645842, DOI: 10.1021/jm801007z *

Also Published As

Publication number Publication date
KR20220041152A (ko) 2022-03-31
JP2022541635A (ja) 2022-09-26
US20220273673A1 (en) 2022-09-01
AU2020319089A1 (en) 2022-03-03
EP4003201A4 (en) 2023-08-23
WO2021016583A1 (en) 2021-01-28
JP7580815B2 (ja) 2024-11-12
CA3145403A1 (en) 2021-01-28
EP4003201A1 (en) 2022-06-01

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Application publication date: 20220603