CN114555059A - 含硝羟喹啉的药物组合物、硝羟喹啉片剂及其制备方法和用途 - Google Patents
含硝羟喹啉的药物组合物、硝羟喹啉片剂及其制备方法和用途 Download PDFInfo
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- CN114555059A CN114555059A CN202080069968.3A CN202080069968A CN114555059A CN 114555059 A CN114555059 A CN 114555059A CN 202080069968 A CN202080069968 A CN 202080069968A CN 114555059 A CN114555059 A CN 114555059A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- Organic Chemistry (AREA)
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Abstract
公开了一种含硝羟喹啉的药物组合物、硝羟喹啉片剂及其制备方法和用途。该药物组合物包括活性药物成分以及药学上可接受的载体，所述活性药物成分为硝羟喹啉或其药学上可接受的盐，所述活性药物成分的粒径D90为10‑100μm。含硝羟喹啉的药物组合物，能够制得溶出速度适中的硝羟喹啉片剂。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911405993X | 2019-12-31 | ||
| CN201911405993 | 2019-12-31 | ||
| PCT/CN2020/141424 WO2021136381A1 (zh) | 2019-12-31 | 2020-12-30 | 含硝羟喹啉的药物组合物、硝羟喹啉片剂及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114555059A true CN114555059A (zh) | 2022-05-27 |
Family
ID=76685940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN202080069968.3A Pending CN114555059A (zh) | 2019-12-31 | 2020-12-30 | 含硝羟喹啉的药物组合物、硝羟喹啉片剂及其制备方法和用途 |
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| Country | Link |
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| US (1) | US20230000853A1 (zh) |
| EP (1) | EP4085902A4 (zh) |
| CN (1) | CN114555059A (zh) |
| TW (1) | TW202135813A (zh) |
| WO (1) | WO2021136381A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2149632C1 (ru) * | 1999-09-09 | 2000-05-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Противомикробное средство и способ его получения |
| CN102239149A (zh) * | 2008-10-06 | 2011-11-09 | 约翰·霍普金斯大学 | 喹啉化合物作为血管新生、人类甲硫氨酰氨肽酶、以及sirt1的抑制剂,以及治疗病症的方法 |
| CN105228984A (zh) * | 2013-03-15 | 2016-01-06 | 爱西里斯药物技术有限公司 | 硝羟喹啉碱加成盐及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446069A (zh) * | 2012-05-29 | 2013-12-18 | 重庆医药工业研究院有限责任公司 | 一种阿比特龙的口服固体组合物及其制备方法 |
| CN103319404A (zh) * | 2013-05-30 | 2013-09-25 | 苏州康润医药有限公司 | 一种硝羟喹啉衍生物及其作为血管生成抑制剂的应用 |
| KR20180129873A (ko) * | 2016-03-31 | 2018-12-05 | 아시이리스 파머수티클 테크놀로지스 코퍼레이션 리미티드 | 암 치료에서 니트록솔린 및 그의 유사체의 화학요법 및 면역요법과의 조합적 사용 |
| CN109106715B (zh) * | 2017-06-23 | 2023-01-31 | 中国科学院上海药物研究所 | 8-羟基喹啉类药物或其盐在制备用于治疗与brd4相关的疾病的药物中的应用 |
-
2020
- 2020-12-30 WO PCT/CN2020/141424 patent/WO2021136381A1/zh unknown
- 2020-12-30 US US17/757,801 patent/US20230000853A1/en active Pending
- 2020-12-30 EP EP20908545.5A patent/EP4085902A4/en active Pending
- 2020-12-30 CN CN202080069968.3A patent/CN114555059A/zh active Pending
- 2020-12-31 TW TW109147108A patent/TW202135813A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2149632C1 (ru) * | 1999-09-09 | 2000-05-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Противомикробное средство и способ его получения |
| CN102239149A (zh) * | 2008-10-06 | 2011-11-09 | 约翰·霍普金斯大学 | 喹啉化合物作为血管新生、人类甲硫氨酰氨肽酶、以及sirt1的抑制剂,以及治疗病症的方法 |
| CN105228984A (zh) * | 2013-03-15 | 2016-01-06 | 爱西里斯药物技术有限公司 | 硝羟喹啉碱加成盐及其用途 |
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| 林宁: "《生物药剂学与药物动力学》", vol. 1, 中国中医药出版社, pages: 27 - 29 * |
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| Publication number | Publication date |
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| WO2021136381A1 (zh) | 2021-07-08 |
| TW202135813A (zh) | 2021-10-01 |
| US20230000853A1 (en) | 2023-01-05 |
| EP4085902A1 (en) | 2022-11-09 |
| EP4085902A4 (en) | 2024-01-10 |
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