CN114533817A - Composition for improving blood sugar and/or blood fat and application thereof - Google Patents
Composition for improving blood sugar and/or blood fat and application thereof Download PDFInfo
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- CN114533817A CN114533817A CN202011331106.1A CN202011331106A CN114533817A CN 114533817 A CN114533817 A CN 114533817A CN 202011331106 A CN202011331106 A CN 202011331106A CN 114533817 A CN114533817 A CN 114533817A
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- kudzu root
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- rhizoma polygonati
- blood sugar
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a composition for improving blood sugar and/or blood fat, which comprises the following components: 1-5 parts of kudzu root and 1 part of rhizoma polygonati. The composition provided by the invention is a medicinal material with homology of medicine and food, is safe and reliable, and the inventor discovers that the kudzuvine root and the rhizoma polygonati have a synergistic interaction effect and can reduce blood sugar and blood fat.
Description
Technical Field
The invention relates to the technical field of foods and health-care products, in particular to a composition for improving blood sugar and/or blood fat and application thereof.
Background
With the improvement of living standard and the acceleration of life rhythm of people, the problems of hypertension, hyperglycemia and hyperlipidemia become more serious day by day, thereby affecting the health and life quality of people.
Among them, the prevalence of diabetes rose dramatically from 0.67% in 1980 to 10.4% in 2013. Worldwide diabetics are expected to grow to 3.8 billion by 2030. The proportion of diabetic patients in China is also increased year by year, the phenomenon is particularly obvious in middle-aged and elderly people, and diabetes becomes a main public health problem which seriously affects physical and psychological health of people in China. The diabetes is generally treated by oral medicines or insulin injection, the insulin injection is expensive and has certain dependence, and the main problem of oral administration is that the side effect of the medicines on organs such as stomach, kidney and the like is obvious, so that clinically, doctors also recommend diet control firstly for patients in early stage of illness or mild symptoms, and the diet management and blood sugar control become a broad topic in middle-aged and elderly people. The people with blood sugar control face the following troubles in diet: the food cannot be eaten more, but the lack of the food is always concerned about lack of nutrition.
Hyperlipidemia refers to the condition of high blood lipid level, which can directly cause some diseases seriously harming human health, such as atherosclerosis, coronary heart disease, pancreatitis and the like. Dyslipidemia is often accompanied by a variety of cardiovascular risk factors. Blood lipid levels and decline can cause the incidence and mortality of cardiovascular disease to decrease as serum total and LDL cholesterol levels decline.
Therefore, the development of safe and effective products with blood sugar and blood fat reducing effects is very necessary.
Disclosure of Invention
In view of the above, the present invention provides a composition for improving blood sugar and/or blood lipid, and the composition provided by the present invention has a synergistic effect, and can reduce blood sugar and blood lipid.
The invention provides a composition for improving blood sugar and/or blood fat, which comprises the following components:
1-5 parts of kudzu root and 1 part of rhizoma polygonati.
Preferably, the kudzu root is kudzu root extract; the rhizoma Polygonati is rhizoma Polygonati extract.
Preferably, the preparation method of the kudzu root extract comprises the following steps:
pretreating radix Puerariae, extracting with water, centrifuging, concentrating, and drying;
wherein, the weight ratio of the kudzu root to the water is 1: (2-10); the extraction temperature is 50-100 ℃; the extraction time is 30-60 min.
Preferably, the preparation method of the polygonatum sibiricum extract specifically comprises the following steps:
pretreating rhizoma Polygonati, extracting with water, centrifuging, concentrating, and drying;
wherein the weight ratio of rhizoma polygonati to water is 1: (2-10); the extraction temperature is 50-100 ℃; the extraction time is 30-60 min.
Preferably, the mass ratio of the kudzu root to the rhizoma polygonati in the composition is (1-4): 1.
Preferably, the mass ratio of the kudzu root to the rhizoma polygonati in the composition is (1-3) to 1.
Preferably, the mass ratio of the kudzu root to the rhizoma polygonati in the composition is (1-2) to 1.
The invention provides application of the composition in the technical scheme in preparation of products for improving blood sugar and/or blood fat.
The invention provides a product for improving blood sugar and/or blood fat, which comprises the composition for improving blood sugar and/or blood fat in any one of the technical schemes.
Preferably, the product is in the form of tablets, powders, granules or emulsions.
Compared with the prior art, the invention provides a composition for improving blood sugar and/or blood fat, which comprises the following components: 1-5 parts of kudzu root and 1 part of rhizoma polygonati. The composition provided by the invention is a medicinal material with homology of medicine and food, is safe and reliable, and the inventor discovers that the kudzuvine root and the rhizoma polygonati have a synergistic interaction effect and can reduce blood sugar and blood fat.
Detailed Description
The invention provides a composition for improving blood sugar and/or blood fat and application thereof, and a person skilled in the art can use the content for reference and appropriately improve process parameters to realize the purpose. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The invention provides a composition for improving blood sugar and/or blood fat, which comprises the following components:
1-5 parts of kudzu root and 1 part of rhizoma polygonati.
The composition for improving blood sugar and/or blood fat comprises 1-5 parts by weight of kudzu root; specifically, it may be 1 part by weight, 2 parts by weight, 3 parts by weight, 4 parts by weight, or 5 parts by weight, or a point value between any two of the above values.
The kudzu root is a kudzu root extract.
According to the invention, the preparation method of the kudzuvine root extract preferably comprises the following steps:
pretreating radix Puerariae, extracting with water, centrifuging, concentrating, and drying;
firstly, kudzu roots are subjected to pretreatment such as cleaning, crushing, homogenate and the like. The present invention is not limited to the specific manner of pretreatment, and those skilled in the art will be familiar with the present invention.
Then extracting with water.
Wherein, the weight ratio of the kudzuvine root to the water is preferably 1: (2-10); more preferably 1: (3-8); most preferably 1: (4-6).
The extraction temperature is preferably 50-100 ℃; more preferably 60-90 ℃; the extraction time is 30-60 minutes; more preferably 40 to 50 minutes.
After extraction, the extract is obtained by centrifugation, concentration and drying. The present invention is not limited to the specific manner of centrifugation, concentration and drying, and may be well known to those skilled in the art.
Kudzu root, name of Chinese traditional medicine. Is dried root of Pueraria lobata Ohwi of Leguminosae, commonly known as Pueraria lobata Ohwi. Collected in autumn and winter, and cut into thick slices or small blocks when fresh; and (5) drying. Sweet, pungent and cool. Has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea. It is commonly indicated for exterior syndrome with fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency.
The composition for improving blood sugar and/or blood fat provided by the invention comprises 1 part by weight of rhizoma polygonati.
The sealwort is a sealwort extract;
the preparation method of the polygonatum sibiricum extract specifically comprises the following steps:
pretreating rhizoma Polygonati, extracting with water, centrifuging, concentrating, and drying;
firstly, rhizoma polygonati is subjected to pretreatment such as cleaning, crushing, homogenate and the like. The present invention is not limited to the specific manner of pretreatment, and those skilled in the art will be familiar with the present invention.
Then extracting with water.
Wherein, the weight ratio of the sealwort to the water is preferably 1: (2-10); more preferably 1: (3-8); most preferably 1: (4-6).
The extraction temperature is preferably 50-100 ℃; more preferably 60-90 ℃; the extraction time is 30-60 minutes; more preferably 40 to 50 minutes.
After extraction, the extract is obtained by centrifugation, concentration and drying. The present invention is not limited to the specific manner of centrifugation, concentration and drying, and may be well known to those skilled in the art.
Polygonatum sibiricum (scientific name: Polygonatum sibiricum), also known as: rhizoma Polygonati, herba Elsholtziae Pendulifoliae, rhizoma Gynurae Divaricatae, rhizoma Zingiberis recens, and radix Codonopsis Lanceolatae. Is a plant of Polygonatum with transverse rhizome, cylindrical shape and enlarged nodule. The impeller is raw and has no handle. The medicinal plant has the functions of invigorating spleen, moistening lung and promoting fluid production.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root to the polygonatum sibiricum in the composition is (1-4): 1.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root to the polygonatum rhizome in the composition is (1-3): 1.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root to the polygonatum rhizome in the composition is (1-2): 1.
In a part of preferred embodiments of the present invention, the mass ratio of pueraria lobata to polygonatum sibiricum in the composition is 1: 1.
The invention also provides a preparation method of the composition for improving blood sugar and/or blood fat, which comprises the following steps:
mixing rhizoma Polygonati extract and radix Puerariae extract.
In the present invention, the source of the extract is not limited, and the extract may be commercially available or prepared by the above-mentioned preparation method.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root extract to the polygonatum sibiricum extract in the composition is (1-5): 1.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root extract to the polygonatum sibiricum extract in the composition is (1-4): 1.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root extract to the polygonatum sibiricum extract in the composition is (1-3): 1.
In a part of preferable embodiments of the invention, the mass ratio of the kudzu root extract to the polygonatum sibiricum extract in the composition is (1-2): 1.
In a part of preferred embodiments of the present invention, the mass ratio of the pueraria extract to the polygonatum extract in the composition is 1: 1.
The invention provides application of the composition in the technical scheme in preparation of products for improving blood sugar and/or blood fat.
The composition provided by the invention is a medicinal material with homology of medicine and food, is safe and reliable, and the inventor discovers that the kudzuvine root and the rhizoma polygonati have a synergistic interaction effect and can reduce blood sugar and blood fat.
The invention provides a product for improving blood sugar and/or blood fat, which comprises the composition for improving blood sugar and/or blood fat in any one of the technical schemes.
The product of the invention also comprises auxiliary materials, which are not limited by the invention and are well known to those skilled in the art.
Wherein the dosage form of the product is tablets, powder, granules or emulsion.
The invention also provides a method for improving blood sugar, which comprises the step of administering the composition for improving blood sugar and/or blood fat according to any one of the technical schemes.
The mode of administration of the present invention is not limited, and the administration may be oral.
The invention also provides a method for improving blood fat, which comprises the step of administering the composition for improving blood sugar and/or blood fat, which is disclosed by any one of the technical schemes.
The mode of administration of the present invention is not limited, and the administration may be oral.
The invention provides a composition for improving blood sugar and/or blood fat, which comprises the following components: 1-5 parts of kudzu root and 1 part of rhizoma polygonati. The composition provided by the invention is a medicinal material with homology of medicine and food, is safe and reliable, and the inventor discovers that the kudzuvine root and the rhizoma polygonati have a synergistic interaction effect and can reduce blood sugar and blood fat.
In order to further illustrate the present invention, the following will describe a composition for improving blood sugar and/or blood lipid and its application in detail with reference to the examples. The compositions in the examples and the comparative examples have the same weight, but the proportions are different.
Example 1 preparation of extract
Washing radix Puerariae with water, crushing, homogenizing, extracting with 5 times of water at 90 deg.C for 40min, centrifuging, concentrating, and drying to obtain radix Puerariae extract.
Washing rhizoma Polygonati with water, crushing, homogenizing, extracting with 5 times of water at 90 deg.C for 40min, centrifuging, concentrating, and drying to obtain rhizoma Polygonati extract.
Example 2
The pueraria extract and the polygonatum extract prepared in example 1 were mixed at a ratio of 1:1 to obtain a composition.
Example 3
The kudzu root extract and the polygonatum extract prepared in example 1 were mixed at a ratio of 2:1 to obtain a composition.
Example 4
The kudzu root extract and the polygonatum extract prepared in example 1 were mixed at a ratio of 5:1 to obtain a composition.
Comparative example 1
The pueraria extract and the polygonatum extract prepared in example 1 were mixed at a ratio of 1:2 to obtain a composition.
Comparative example 2
The pueraria extract and the polygonatum extract prepared in example 1 were mixed at a ratio of 1:5 to obtain a composition.
Example 5 Zebra fish experiment
1. The experimental scheme is as follows:
1.1. zebrafish strain: wild type AB strains, 30-tailed zebrafish per experimental group, were incubated in an incubator at 28 ℃.
1.2. Establishing a model: treating normal zebra fish with the high-sugar and high-fat feed in a water-soluble administration mode, and establishing a high-sugar and high-fat model.
1.3. Experimental groups were as follows: the total number of the groups is 10. The kudzu root and sealwort formula is prepared from 5 groups of kudzu root and sealwort according to 5 proportions, 1 concentration of each group, 5 groups of the kudzu root, 1 model control group, 1 positive control group (pioglitazone) and 1 normal control group (water treatment group for fish farming).
1.4. The administration mode comprises the following steps: the test samples of each example and comparative example were treated with model zebra fish by dissolving in water. Wherein the total content of the kudzuvine root and the manyflower solomonseal rhizome in each example and comparative example is 600 mug/mL. The rhizoma Polygonati control group is 600 μ g/mL; the radix Puerariae control group was 600 μ g/mL.
1.5. The experimental method comprises the following steps: after the test article treatment, 30 zebra fish were collected from each experimental group, and the blood glucose level (G) was measured with a glucometer. Statistical treatment results are expressed as Mean ± SE; the formula for calculating the hypoglycemic effect of the test sample is as follows:
1.6. statistical analysis using T-test, p <0.05 was significantly different.
2. The experimental results are as follows:
as shown in the table above, when the combination of the radix puerariae and the rhizoma polygonati is 1:1, 2:1 and 5:1, the composition has the effect of reducing blood sugar, and the mixture ratio is 1:1, the synergistic effect is 1+1> 2. The composition of the radix puerariae and the rhizoma polygonati has a synergistic effect when the ratio is 1:1, 2:1 and 5:1 compared with a single agent.
Example 6
Firstly, animal efficacy experiment:
1. test samples:
ingredient human recommended dose (mg/d)
Radix Puerariae extract 660
Polygonatum sibiricum extract 600
2. The experimental scheme is as follows:
according to the original national food and drug administration No. 2012/107' notification about 9 health care function evaluation methods such as a printing antioxidant function evaluation method, an SPF male SD rat and a high-fat high-nutrition feed are adopted to establish a glycometabolism disorder animal model, and corresponding plant extract test substances (combinations) are given for intervention.
The experimental animal is an SPF male SD rat with the weight of 160 g-220 g, which is provided by Zhejiang Wintonlihua experimental animal technology Limited company (animal qualification number: SCXK (Zhe) 2019-. Feeding conditions are as follows: SPF-level animal house (license number: SYXK 2018-011). The room temperature is 23 +/-2 ℃, the humidity is 40-70%, the light and shade alternate period is 12h, and the animals can freely eat and drink water. One week after acclimation feeding, the experiment was started.
The experiment is provided with a normal control group, a high-fat high-nutrition model control group, an experiment group 1 and an experiment group 2, and each group contains 10 animals. The control group was fed with normal feed, and the model group and the experimental group were fed with high-fat and high-nutrient feed. The food intake of each group of animals is controlled to be basically consistent, and the animals drink water freely. The animals in each experimental group were fed with the corresponding test samples daily through fasting stomach gavage, and the blank control group and the model control group were fed with stomach distilled water, and the gavage volume was consistent with that of the sample intervention group. Experimental group 1 a test sample of the polygonatum sibiricum and pueraria lobata composition prepared in example 2 was administered at a dose 5 times (equivalent to human dose) of the human dose; experimental group 2 a test sample of the polygonatum sibiricum and pueraria lobata composition prepared in example 2 was administered in an amount 20 times that of a human body. The experiment lasted 49 days. And (4) collecting blood after anesthesia of animals on 0 day and 29 days of experiment to detect related indexes. On the 50 th day of the experiment, blood is collected after the animals are anesthetized, and blood sugar indexes are detected. The experimental data were statistically analyzed using PEMS for Windows 3.1 statistical software.
3. The experimental results are as follows:
tangle-solidup, P <0.05 compared to normal control group; p <0.05 compared to model control group
Tangle-solidup, P <0.05 x, compared to model control group
The experimental results show that the polygonatum sibiricum and kudzuvine root composition has the effects of reducing blood sugar and blood fat.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A composition for improving blood glucose and/or blood lipid comprising:
1-5 parts of kudzu root and 1 part of rhizoma polygonati.
2. The composition of claim 1, wherein the kudzu root is kudzu root extract; the rhizoma Polygonati is rhizoma Polygonati extract.
3. The composition as claimed in claim 2, wherein the preparation method of the pueraria lobata extract comprises:
pretreating radix Puerariae, extracting with water, centrifuging, concentrating, and drying;
wherein, the weight ratio of the kudzu root to the water is 1: (2-10); the extraction temperature is 50-100 ℃; the extraction time is 30-60 min.
4. The composition as claimed in claim 2, wherein the preparation method of the polygonatum sibiricum extract comprises the following steps:
pretreating rhizoma Polygonati, extracting with water, centrifuging, concentrating, and drying;
wherein the weight ratio of rhizoma polygonati to water is 1: (2-10); the extraction temperature is 50-100 ℃; the extraction time is 30-60 min.
5. The composition as claimed in any one of claims 1 to 4, wherein the mass ratio of the kudzu root to the polygonatum sibiricum in the composition is (1-4): 1.
6. The composition as claimed in any one of claims 1 to 4, wherein the mass ratio of the kudzu root to the polygonatum sibiricum in the composition is (1-3): 1.
7. The composition as claimed in any one of claims 1 to 4, wherein the mass ratio of the kudzu root to the polygonatum sibiricum in the composition is (1-2): 1.
8. Use of a composition according to any one of claims 1 to 7 for the preparation of a product for improving blood glucose and/or blood lipid levels.
9. A product for improving blood sugar and/or blood fat, which comprises the composition for improving blood sugar and/or blood fat of any one of claims 1 to 7.
10. The product of claim 9, wherein the product is in the form of a tablet, powder, granule, or emulsion.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808138A (en) * | 2023-07-20 | 2023-09-29 | 厚德祖康生物制药有限公司 | Natto composition for regulating intestines and stomach and reducing blood fat and application thereof |
-
2020
- 2020-11-24 CN CN202011331106.1A patent/CN114533817A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 马汴梁: "《排毒养颜茶酒方》", 28 February 2014 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808138A (en) * | 2023-07-20 | 2023-09-29 | 厚德祖康生物制药有限公司 | Natto composition for regulating intestines and stomach and reducing blood fat and application thereof |
| CN116808138B (en) * | 2023-07-20 | 2024-03-08 | 厚德祖康生物制药有限公司 | Natto composition for regulating intestines and stomach and reducing blood fat and application thereof |
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