CN114533805A - External prescription for cervical and lumbar diseases - Google Patents
External prescription for cervical and lumbar diseases Download PDFInfo
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- CN114533805A CN114533805A CN202210271512.6A CN202210271512A CN114533805A CN 114533805 A CN114533805 A CN 114533805A CN 202210271512 A CN202210271512 A CN 202210271512A CN 114533805 A CN114533805 A CN 114533805A
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 18
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000843 powder Substances 0.000 claims abstract description 33
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 150000001875 compounds Chemical class 0.000 claims abstract description 24
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960001484 edetic acid Drugs 0.000 claims abstract description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 19
- 229960001631 carbomer Drugs 0.000 claims abstract description 19
- 235000013162 Cocos nucifera Nutrition 0.000 claims abstract description 18
- 244000060011 Cocos nucifera Species 0.000 claims abstract description 18
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 16
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 16
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 16
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 16
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 16
- 241000096284 Gynochthodes officinalis Species 0.000 claims abstract description 16
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 16
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- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 16
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- 238000003756 stirring Methods 0.000 claims description 13
- UTUUIUQHGDRVPU-UHFFFAOYSA-K aluminum;2-aminoacetate;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Al+3].NCC([O-])=O UTUUIUQHGDRVPU-UHFFFAOYSA-K 0.000 claims description 9
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- QUVCFQAHXXKABX-UHFFFAOYSA-K C(CO)(=O)[O-].O[Al+]O Chemical compound C(CO)(=O)[O-].O[Al+]O QUVCFQAHXXKABX-UHFFFAOYSA-K 0.000 claims description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Medical Informatics (AREA)
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- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
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- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The invention discloses an external prescription for cervical and lumbar diseases, which relates to the technical field of external products of traditional Chinese medicines and comprises the following raw materials in parts by weight: 0.5-2.0 parts of carbomer, 0.3-0.8 part of NP-7008.0, 0.3-0.8 part of dihydroxyaluminum glycinate, 30-60 parts of glycerol, 0.01-0.07 part of EDTA (ethylene diamine tetraacetic acid), 0.05-0.3 part of citric acid, 35-50 parts of compound fine powder and 80-100 parts of water, wherein the compound fine powder is prepared from the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root. The invention relates to an external prescription for treating cervical and lumbar diseases, which takes mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root as raw materials, combines the raw materials, has obvious synergistic effect, and has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, and dispelling cold and relieving pain, thereby having obvious relieving effect on neck and shoulder discomfort and waist and leg ache caused by damp-cold wind evil in the cervical and lumbar parts.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine external products, in particular to an external prescription for cervical and lumbar diseases.
Background
Cervical and lumbar diseases refer to corresponding symptoms and signs of spinal cord, nerve and blood vessel damage caused by degeneration of cervical and lumbar intervertebral discs and degeneration of secondary intervertebral joints. Is one of the common diseases of the old. However, with the change of the living and working habits of modern people, the chances of single posture strain increase, the incidence rate of cervical and lumbar diseases tends to rise, and patients tend to be younger. Although the treatment methods for the diseases are many, the pain of the patient can be relieved fast and effectively, and the theory of 'low back pain of the patient and headache of doctors' is easily realized
Although the plaster in the external prescription in the market at present is a pasting preparation with a long use history, the plaster has more defects, such as the black plaster selects lead ions as a matrix, is harmful to human bodies after long-term use, is prepared under a high-temperature condition, is not beneficial to the protection of effective components, and has pain when being torn off; the preparation of the rubber paste needs a large amount of gasoline, has potential safety hazard and is not beneficial to environmental protection.
Disclosure of Invention
The invention mainly aims to provide an external prescription for cervical and lumbar diseases, which can effectively solve the problems that the black plaster in the background technology selects lead ions as a substrate, is harmful to human bodies after long-term use, is not beneficial to the protection of effective components because the processing is carried out under the high-temperature condition, has pain when being torn off, and the like; the preparation of the rubber paste needs a large amount of gasoline, has potential safety hazard and is not beneficial to environmental protection.
In order to achieve the purpose, the invention adopts the technical scheme that: an external prescription for cervical and lumbar diseases comprises the following raw materials in parts by weight: 0.5-2.0 parts of carbomer, 0.3-0.8 part of NP-7008.0-10.0 parts of dihydroxyaluminum glycinate, 30-60 parts of glycerol, 0.01-0.07 part of EDTA (ethylene diamine tetraacetic acid), 0.05-0.3 part of citric acid, 35-50 parts of compound fine powder and 80-100 parts of water, wherein the compound fine powder is prepared from the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root.
Preferably, the method comprises the following steps:
s1, weighing ramulus Mori, folium Artemisiae Argyi, coconut shell, radix Morindae officinalis and radix Polygoni Multiflori Preparata at a certain weight part according to the above formula, processing into powder respectively in a micronizer, sieving with a sieve, drying, and mixing completely;
s2, filling the mixed finished product into a non-woven cloth bag with the size of about 11cm multiplied by 8cm, and sealing the bag;
s3, adding purified water into a container storing a certain amount of carbomer, soaking for 12h, adding EDTA into the soaked carbomer solution, uniformly stirring to obtain phase A, putting NP-700, dihydroxyaluminum glycolate and glycerol into a large stainless steel container, and uniformly stirring to obtain phase B;
and S4, adding the phase B into the phase A, placing the phase A into a vacuum stirrer, stirring to obtain a paste, taking out the paste, coating the paste on a non-woven fabric bag, and placing the non-woven fabric bag at room temperature after coating to naturally solidify and form the non-woven fabric bag.
Preferably, the fine powder obtained in step S1 is filtered through a filter sieve of 100 to 150 meshes to obtain a fine powder having a particle size of 100 to 150 μm.
Preferably, the stirring speed of the vacuum stirrer in the step S4 is 120-160 r/min, and the stirring time is about 5 min.
Preferably, the external prescription consists of the following raw materials in parts by weight: 0.5 part of carbomer, 0.3 part of NP-7008.0 part of dihydroxyaluminium aminoacetate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
Preferably, the external prescription consists of the following raw materials in parts by weight: the external prescription consists of the following raw materials in parts by weight: 1.0 part of carbomer, 0.5 part of NP-7009.0 part of dihydroxyaluminium aminoacetate, 50 parts of glycerol, 0.05 part of EDTA, 0.2 part of citric acid, 40 parts of compound fine powder and 90 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
Preferably, the external prescription consists of the following raw materials in parts by weight: 2.0 parts of carbomer, 0.8 part of NP-70010.0 part of dihydroxyaluminium aminoacetate, 60 parts of glycerol, 0.07 part of EDTA, 0.3 part of citric acid, 50 parts of compound fine powder and 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
Compared with the prior art, the invention has the following beneficial effects:
1. in the invention, in the forming process, the substrate is directly placed at room temperature after being coated and is naturally cured and formed without heating, so that the water evaporation is avoided, the preparation process is simplified, the protection of active ingredients is facilitated, the substrate is basically free of pain when being torn off, the comfort of a patient in use is improved, a steel ball with the sticking weight of 5.6g can be obtained through the adhesion experiment result and the heat resistance detection, and the holding adhesion test is more than 150 seconds, so that the external preparation has good adhesion and can be well fixed at a diseased part, and the heat resistance of the external preparation can reach 50 ℃.
2. In the invention, the existing paste refining process usually needs heating, and the substrates selected by the invention are NP-700 and carbomer high molecular polymer, so that the paste can be well dissolved at room temperature, heating is not needed in the paste refining process, and the operation is simple.
3. According to the traditional Chinese medicine composition, the mulberry twigs play a role in strengthening bones, the wormwood plays a role in warming, the coconut shells play a role in dispelling wind, the morinda officinalis and the radix polygoni multiflori preparata play a role in tonifying kidney and strengthening bones, and data after treatment of a plurality of groups of patients are counted, so that the total effective rate of the traditional Chinese medicine composition can reach 83.33%, and the traditional Chinese medicine composition has a remarkable relieving effect on neck and shoulder discomfort, waist and leg ache caused by damp, cold and wind evil in neck and lumbar.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
The external prescription for the cervical spondylosis and the lumbar spondylosis comprises the following raw materials in parts by weight: 0.5 part of carbomer, 0.3 part of NP-7008.0 part of dihydroxyaluminium aminoacetate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
The manufacturing steps are as follows; selecting 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root, placing the mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root in an ultrafine pulverizer, pulverizing into fine powder with the powder diameter of 100-150 mu m, drying, fully mixing to obtain the product, then putting the mixed product into a non-woven cloth bag with the size of about 11cm multiplied by 8cm, sealing to form a bag, then adding purified water into a container containing 0.5 part of carbomer, soaking for 12 hours, then adding 0.01 part of EDTA into the soaked carbomer solution, stirring uniformly to obtain phase A, then placing 8.0 part of NP-700, 0.3 part of aluminium glycerolate and 30 parts of glycerol into a stainless steel large container, stirring uniformly to obtain phase B, finally placing phase B into phase A, placing into a vacuum stirrer, stirring for 5min under the condition of 140r/min, then taking out the non-woven cloth tape, spreading the non-woven paste on the A, and after coating, placing the mixture at room temperature for natural curing and forming to obtain a finished product.
Example 2
The difference between the embodiment and the embodiment 1 is that the parts by weight of the components are different, wherein the parts by weight of the components comprise 1.0 part of carbomer, 7009.0 parts of NP-7009.0 parts of dihydroxyaluminium aminoacetate, 50 parts of glycerol, 0.05 part of EDTA (ethylene diamine tetraacetic acid), 0.2 part of citric acid, 40 parts of compound fine powder and 90 parts of water, and the compound fine powder comprises the following raw materials in parts by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
Example 3
The difference between the embodiment and the embodiment 1 is that the parts by weight of the components are different, wherein the parts by weight of the components comprise 2.0 parts of carbomer, 70010.0 parts of NP-70010.0 parts of dihydroxyaluminium aminoacetate, 60 parts of glycerin, 0.07 part of EDTA (ethylene diamine tetraacetic acid), 0.3 part of citric acid, 50 parts of compound fine powder and 100 parts of water, and the compound fine powder comprises the following raw materials in parts by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
Comparative example
The comparative example used a commercially available black plaster.
The prescription is clinically tested, 30 persons with discomfort of the cervical vertebra and the lumbar vertebra are randomly selected, then the prescription is pasted on the corresponding uncomfortable skin surface of a patient and fixed, the specific method is that the prescription is used once a day before sleeping at night, the prescription is taken off after morning, the patch is continuously used for 8-10 hours, and every 5 days is taken as a period, if the prescription is effective, the period is prolonged by 1-2, and if the prescription is ineffective, the trial is stopped. The statistical results are shown in the following table 1:
TABLE 1 therapeutic results
The data in the table 1 can show that the total effective rate reaches 83.33 percent in the treatment of the 30 patients, which indicates that the traditional Chinese medicine composition can play a more obvious relieving effect on neck and shoulder discomfort and waist and leg ache of the cervical vertebra and the lumbar caused by damp, cold and wind evil.
The results of randomly selecting 50 persons, 28 women and 22 men, and attaching the plaster of the example and the plaster of the comparative example to the left and right arms of each person were as follows:
TABLE 2 differences between examples and comparative examples
From the above table 2, it can be found that the probability that the user feels pain when tearing off the paper is low after the paper is used, and the probability that the user feels pain when tearing off the paper is more than 50% in the prior art, so that the comfort of the paper is good when the paper is used.
Initial adhesion measurement was carried out by removing the anti-blocking paper from the cataplasm and leaving the cataplasm at room temperature for 2 hours or more without overlapping each other. Wiping off the surfaces of the inclined plate and the stainless steel ball, and flatly fixing the adhesive surface of the patch upwards on the inclined plate by using a double-faced adhesive tape. And (4) freely rolling down steel balls with different specifications from the top end of the inclined plane, and recording the maximum ball number which can be stuck on the paste surface. And (3) measuring the holding power, namely cleaning the test plate and the loading plate by absolute ethyl alcohol before the experiment, cutting the test plate and the loading plate into samples of 5cm multiplied by 8cm, longitudinally sticking the samples to the middle parts of the test plate and the loading plate which are close to each other, rolling the samples on the sample by a press roller for three times, after sticking the sample on the plate, placing the sample at room temperature for 20min, and fixing the sample on a test frame. And hanging a 200g weight, and recording the time of the test article falling off from the test board. The results are given in Table 3 below.
Table 3 results of adhesion test
According to the experimental results, the temporary initial adhesion test can adhere No. 15 steel balls (the weight of the steel balls is 5.6g), and the holding adhesion test is more than 150s, so that the external preparation provided by the invention is good in adhesion and can be well fixed at the affected part.
2 pieces of each three batches of samples of the external prescription are taken, the lining is removed, the samples are heated for 3 hours at 50 ℃, and after the samples are naturally cooled, the samples are observed, so that the back surface of the paste has no turbidity phenomenon, the surface of the paste is smooth, the paste still has viscosity when being touched by fingers, and the external prescription conforms to the regulation, and the external prescription has good heat resistance.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, and such changes and modifications are within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (7)
1. An external prescription for cervical and lumbar diseases is characterized in that: the composite material comprises the following raw materials in parts by weight: 0.5-2.0 parts of carbomer, 0.3-0.8 part of NP-7008.0, 0.3-0.8 part of dihydroxyaluminum glycinate, 30-60 parts of glycerol, 0.01-0.07 part of EDTA (ethylene diamine tetraacetic acid), 0.05-0.3 part of citric acid, 35-50 parts of compound fine powder and 80-100 parts of water, wherein the compound fine powder is prepared from the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root.
2. The external prescription for cervical and lumbar diseases according to claim 1, characterized in that: the method comprises the following steps:
s1, weighing ramulus Mori, folium Artemisiae Argyi, coconut shell, radix Morindae officinalis and radix Polygoni Multiflori Preparata at a certain weight part according to the above formula, processing into powder respectively in a micronizer, sieving with a sieve, drying, and mixing completely;
s2, filling the mixed product into a non-woven cloth bag with the size of about 11cm multiplied by 8cm, and sealing the bag;
s3, adding purified water into a container storing a certain amount of carbomer, soaking for 12h, adding EDTA into the soaked carbomer solution, uniformly stirring to obtain phase A, putting NP-700, dihydroxyaluminum glycolate and glycerol into a large stainless steel container, and uniformly stirring to obtain phase B;
and S4, adding the phase B into the phase A, placing the phase A into a vacuum stirrer, stirring to obtain a paste, taking out the paste, coating the paste on a non-woven fabric bag, and placing the non-woven fabric bag at room temperature after coating to naturally solidify and form the non-woven fabric bag.
3. The external prescription for cervical and lumbar diseases according to claim 2, characterized in that: and (S1) filtering the fine powder obtained in the step (S1) through a filter sieve of 100-150 meshes to obtain the fine powder with the powder diameter of 100-150 mu m.
4. A cervical or lumbar disease topical formulation according to claim 3, characterized in that: and in the step S4, the stirring speed of the vacuum stirrer is 120-160 r/min, and the stirring time is about 5 min.
5. The external preparation for cervical or lumbar diseases according to claim 4, wherein: the external prescription consists of the following raw materials in parts by weight: 0.5 part of carbomer, 0.3 part of NP-7008.0 part of dihydroxyaluminium aminoacetate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
6. The external preparation for cervical or lumbar diseases according to claim 5, wherein: the external prescription consists of the following raw materials in parts by weight: 1.0 part of carbomer, 0.5 part of NP-7009.0 part of dihydroxyaluminium aminoacetate, 50 parts of glycerol, 0.05 part of EDTA, 0.2 part of citric acid, 40 parts of compound fine powder and 90 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
7. The external prescription for cervical and lumbar diseases according to claim 6, wherein: the external prescription consists of the following raw materials in parts by weight: 2.0 parts of carbomer, 0.8 part of NP-70010.0 part of dihydroxyaluminium aminoacetate, 60 parts of glycerol, 0.07 part of EDTA, 0.3 part of citric acid, 50 parts of compound fine powder and 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
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