CN114533805B - External prescription for cervical vertebra and lumbar vertebra diseases - Google Patents
External prescription for cervical vertebra and lumbar vertebra diseases Download PDFInfo
- Publication number
- CN114533805B CN114533805B CN202210271512.6A CN202210271512A CN114533805B CN 114533805 B CN114533805 B CN 114533805B CN 202210271512 A CN202210271512 A CN 202210271512A CN 114533805 B CN114533805 B CN 114533805B
- Authority
- CN
- China
- Prior art keywords
- parts
- raw materials
- fine powder
- weight
- external prescription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000029761 vertebral disease Diseases 0.000 title claims description 9
- 239000000843 powder Substances 0.000 claims abstract description 41
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 150000001875 compounds Chemical class 0.000 claims abstract description 24
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 19
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 19
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 19
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 19
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 19
- 244000060011 Cocos nucifera Species 0.000 claims abstract description 19
- 235000013162 Cocos nucifera Nutrition 0.000 claims abstract description 19
- 241000096284 Gynochthodes officinalis Species 0.000 claims abstract description 19
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 19
- 240000000249 Morus alba Species 0.000 claims abstract description 19
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 19
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 19
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 19
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 19
- 229960001631 carbomer Drugs 0.000 claims abstract description 19
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000011187 glycerol Nutrition 0.000 claims abstract description 15
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 8
- 229940070818 glycyrrhizate Drugs 0.000 claims abstract description 8
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 13
- 239000004745 nonwoven fabric Substances 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- HDVDLQFPDLTOSI-UHFFFAOYSA-L O[AlH]O Chemical compound O[AlH]O HDVDLQFPDLTOSI-UHFFFAOYSA-L 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 206010041591 Spinal osteoarthritis Diseases 0.000 abstract description 8
- 206010053156 Musculoskeletal discomfort Diseases 0.000 abstract description 5
- 208000002193 Pain Diseases 0.000 abstract description 4
- 208000036319 cervical spondylosis Diseases 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 230000036407 pain Effects 0.000 abstract description 4
- 208000005801 spondylosis Diseases 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 13
- 239000011505 plaster Substances 0.000 description 7
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229910000831 Steel Inorganic materials 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- 206010061246 Intervertebral disc degeneration Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 208000019669 cervical disc degenerative disease Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 208000018180 degenerative disc disease Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external prescription for cervical spondylosis and lumbar spondylosis, which relates to the technical field of external traditional Chinese medicine products and comprises the following raw materials in parts by weight: 0.5 to 2.0 parts of carbomer, 8.0 to 10.0 parts of NP-700, 0.3 to 0.8 part of aluminum glycyrrhizate, 30 to 60 parts of glycerin, 0.01 to 0.07 part of EDTA, 0.05 to 0.3 part of citric acid, 35 to 50 parts of compound fine powder and 80 to 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root. The external prescription for cervical spondylosis and lumbar spondylosis has the advantages that mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root are taken as raw materials, the raw materials are combined, the synergistic effect is obvious, and the external prescription has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, dispelling cold and relieving pain, so that the external prescription can play a relatively obvious role in relieving neck and shoulder discomfort and waist and leg ache caused by damp-cold wind evil in the cervical vertebra and lumbar vertebra.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine external products, in particular to an external prescription for cervical spondylosis and lumbar spondylosis.
Background
Cervical and lumbar vertebra diseases refer to the corresponding symptoms and signs of spinal cord, nerve and vascular damage caused by cervical and lumbar disc degeneration and secondary intervertebral joint degeneration. Is one of common diseases of the elderly. However, with the change of life and work habits of modern people, the chances of strain in a single posture are increased, the incidence rate of cervical and lumbar diseases is on an ascending trend, and the age of patients tends to be younger. Although the treatment methods of the diseases are many, the diseases can really and rapidly and effectively relieve less pains of patients, namely' lumbago of patients and headache of doctors
The plaster in the external prescription on the market at present is a plaster preparation with longer use history, but has more defects, such as the black plaster adopts lead ions as a matrix, is harmful to human bodies after long-term use, is processed under high temperature condition, is not beneficial to the protection of active ingredients, has pain when being torn off, and the like; the preparation of the rubber paste requires a large amount of gasoline, has potential safety hazard and is not beneficial to environmental protection.
Disclosure of Invention
The invention mainly aims to provide an external prescription for cervical spondylosis and lumbar spondylosis, which can effectively solve the problems that the black plaster in the background technology takes lead ions as a matrix, is harmful to human bodies after long-term use, and is prepared under high temperature conditions, is not beneficial to the protection of active ingredients, and is painful when torn off; the preparation of the rubber paste requires a large amount of gasoline, has potential safety hazard and is not beneficial to environmental protection.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: an external prescription for cervical vertebra and lumbar vertebra diseases comprises the following raw materials in parts by weight: 0.5 to 2.0 parts of carbomer, 8.0 to 10.0 parts of NP-700, 0.3 to 0.8 part of aluminum glycyrrhizate, 30 to 60 parts of glycerin, 0.01 to 0.07 part of EDTA, 0.05 to 0.3 part of citric acid, 35 to 50 parts of compound fine powder and 80 to 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root.
Preferably, the method comprises the following steps:
s1, weighing certain parts by weight of mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root according to the formula, respectively processing the mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root into powder by a superfine pulverizer, screening the powder by a filter screen, drying the powder, and fully mixing the powder;
s2, placing the mixed finished product into a non-woven fabric bag with the size of about 11cm multiplied by 8cm, and sealing the bag;
s3, adding purified water into a carbomer container with a certain amount, soaking for 12 hours, adding EDTA into the soaked carbomer solution, stirring uniformly to obtain a phase A, putting NP-700, dihydroxyaluminum and glycerol into a stainless steel large container, and stirring uniformly to obtain a phase B;
s4, adding the phase B into the phase A, placing in a vacuum stirrer, stirring to obtain paste, taking out the paste, coating the paste on a non-woven fabric bag, and placing at room temperature after coating, and naturally solidifying and forming the paste.
Preferably, the fine powder obtained in the step S1 is filtered by a 100-150-mesh filter screen, so as to obtain fine powder with a powder diameter of 100-150 mu m.
Preferably, the stirring speed of the vacuum stirrer in the step S4 is 120-160 r/min, and the stirring time is about 5 min.
Preferably, the external prescription comprises the following raw materials in parts by weight: 0.5 part of carbomer, NP-7008.0 parts, 0.3 part of aluminum glycinate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
Preferably, the external prescription comprises the following raw materials in parts by weight: the external prescription comprises the following raw materials in parts by weight: 1.0 part of carbomer, 9.0 parts of NP-700, 0.5 part of aluminum glycyrrhizate, 50 parts of glycerin, 0.05 part of EDTA, 0.2 part of citric acid, 40 parts of compound fine powder and 90 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
Preferably, the external prescription comprises the following raw materials in parts by weight: 2.0 parts of carbomer, NP-70010.0 parts, 0.8 part of aluminum glycinate, 60 parts of glycerin, 0.07 part of EDTA, 0.3 part of citric acid, 50 parts of compound fine powder and 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
Compared with the prior art, the invention has the following beneficial effects:
1. in the invention, the matrix is directly placed under the room temperature condition after being coated in the molding process, and is naturally cured and molded without heating, so that the water evaporation is avoided, the preparation process is simplified, the protection of effective components is facilitated, the pain is basically avoided during tearing, the comfort of a patient in use is improved, the steel ball with the weight of 5.6g can be obtained through the adhesion test result and the heat resistance test, the adhesion test is greater than 150s, the adhesion of the external prescription is good, the external prescription can be well fixed at a diseased part, and the heat resistance of the external prescription can reach 50 ℃.
2. In the invention, the existing paste refining and process needs to be heated, the matrix selected by the invention is NP-700 and carbomer high molecular polymer, which can be well dissolved at room temperature, and the paste refining and process does not need to be heated, so that the operation is simple.
3. According to the invention, the mulberry twig is used for mainly strengthening bones, the wormwood is used for mainly warming, the coconut shell is used for mainly dispelling wind, the morinda officinalis and the prepared fleece-flower root are used for mainly tonifying kidney and strengthening bones, and statistics is carried out on data after treatment on a plurality of groups of patients, so that the total effective rate of the invention can reach 83.33%, and therefore, the invention has a relatively obvious relieving effect on neck-shoulder discomfort and waist-leg ache caused by damp-cold wind evil in the neck and lumbar vertebra.
Detailed Description
The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
In the description of the present invention, it should be noted that the terms "upper," "lower," "inner," "outer," "front," "rear," "both ends," "one end," "the other end," and the like indicate an orientation or a positional relationship, which are merely for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the apparatus or elements to be referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "provided," "connected," and the like are to be construed broadly, and may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Example 1
The external prescription for cervical vertebra and lumbar vertebra diseases of the embodiment comprises the following raw materials in parts by weight: 0.5 part of carbomer, 0.3 part of aluminum glycyrrhizate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
The manufacturing steps are as follows; selecting 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root, placing into an ultrafine grinder, grinding into fine powder with the powder diameter of 100-150 mu m, drying and fully mixing the fine powder, placing the mixed finished product into a non-woven fabric bag with the size of about 11cm multiplied by 8cm, sealing the non-woven fabric bag into a bag, adding purified water into a container with 0.5 part of carbomer, soaking for 12 hours, adding 0.01 part of EDTA into the soaked carbomer solution, uniformly stirring to obtain a phase A, then placing 8.0 parts of NP-700, 0.3 part of aluminum glycinate and 30 parts of glycerol into a stainless steel large container, uniformly stirring to obtain a phase B, finally adding the phase B into the phase A, placing into a vacuum stirrer, stirring for 5min under the condition of 140r/min, taking out the paste, coating the paste, placing the non-woven fabric into a room temperature after coating, curing under the condition, and naturally molding the non-woven fabric.
Example 2
The difference between the present example and example 1 is that the weight parts of the components are different, wherein carbomer 1.0 part, NP-700.0 parts, aluminum glycinate 0.5 parts, glycerin 50 parts, EDTA 0.05 parts, citric acid 0.2 parts, compound fine powder 40 parts, water 90 parts, the compound fine powder is composed of the following raw materials by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
Example 3
The difference between the present example and example 1 is that the weight parts of the components are different, wherein carbomer 2.0 parts, NP-700.0 parts, aluminum glycinate 0.8 parts, glycerin 60 parts, EDTA 0.07 parts, citric acid 0.3 parts, compound fine powder 50 parts, water 100 parts, the compound fine powder is composed of the following raw materials by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
Comparative example
The comparative example used a black plaster on the market.
The prescription is applied to the surface of the uncomfortable skin of a patient and fixed after 30 persons suffering from cervical and lumbar discomfort are randomly selected during clinical trial, and the prescription is specifically applied once daily, used before sleeping every night, torn off after the morning, continuously applied for 8-10 hours, and used for one period every 5 days, if the prescription takes effect, the period is prolonged by 1-2 periods, and if the prescription is ineffective, the trial is terminated. The actual records show that the statistical results are shown in the following table 1:
table 1 treatment results
From the data in the table 1, the total effective rate of the invention reaches 83.33% in the treatment of 30 people, which shows that the invention can play a relatively obvious role in relieving neck and shoulder discomfort, waist and leg ache caused by damp cold wind evil in the neck and lumbar vertebra.
50 persons were randomly selected, of which women 28 persons and men 22 persons, and then each person was attached with the plaster of the example and the plaster of the comparative example on the left and right arms, respectively, with the results shown in table 2 below:
table 2 difference between examples and comparative examples
From the above table 2, it can be seen that the present invention has a low probability of feeling painful when pulled after use, whereas the conventional present invention has a probability of feeling painful when pulled of more than 50%, thus proving that the present invention has good comfort when used.
And (5) measuring primary adhesion, namely removing the anti-adhesion paper from the cataplasm, and standing at room temperature for more than 2 hours without overlapping each other. The surfaces of the inclined plate and the stainless steel ball are wiped, and the adhesive surface of the adhesive patch is upwards and flatly fixed on the inclined plate by using a double-sided adhesive tape. The steel balls with different specifications are freely rolled down from the top end of the inclined plane, and the maximum ball number which can be stuck by the paste surface is recorded. And (3) carrying out adhesion force measurement, namely scrubbing the test plate and the loading plate with absolute ethyl alcohol before an experiment, taking a sample cut into 5cm multiplied by 8cm, longitudinally sticking the sample to the middle parts of the test plate and the loading plate which are close to each other, rolling the sample back and forth for three times by using a compression roller, sticking the sample on the plate, standing for 20min at room temperature, and fixing the sample on a test frame. A 200g weight was hung and the time for the test article to fall off the test plate was recorded. The results are shown in Table 3 below.
Table 3 adhesion test results according to the above test results, the tentative initial adhesion test should be capable of adhering No. 15 steel balls (steel balls weight 5.6 g), and the holding adhesion test is more than 150s, so as to indicate that the external preparation of the present invention has good adhesion and can be well fixed at the affected part.
Taking 2 pieces of three samples of the external prescription of the invention, removing the cover lining, heating at 50 ℃ for 3 hours, and observing after the external prescription is naturally cooled, wherein the back of the ointment has no turbidity, the ointment has smooth surface and still has viscosity after finger touch test, thus the external prescription of the invention has good heat resistance.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. An external prescription for cervical vertebra and lumbar vertebra diseases is characterized in that: the material consists of the following raw materials in parts by weight: 0.5 to 2.0 parts of carbomer, 8.0 to 10.0 parts of NP-700, 0.3 to 0.8 part of aluminum glycyrrhizate, 30 to 60 parts of glycerin, 0.01 to 0.07 part of EDTA, 0.05 to 0.3 part of citric acid, 35 to 50 parts of compound fine powder and 80 to 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 to 7.0 parts of mulberry twig, 5.0 to 6.0 parts of wormwood, 1.0 to 2.0 parts of coconut shell, 1.0 to 2.0 parts of morinda officinalis and 1.0 to 2.0 parts of prepared fleece-flower root;
the method comprises the following steps:
s1, weighing certain parts by weight of mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root according to the formula, respectively processing the mulberry twig, wormwood, coconut shell, morinda officinalis and prepared fleece-flower root into powder by a superfine pulverizer, screening the powder by a filter screen, drying the powder, and fully mixing the powder;
s2, placing the mixed finished product into a non-woven fabric bag with the size of about 11cm multiplied by 8cm, and sealing the bag;
s3, adding purified water into a carbomer container with a certain amount, soaking for 12 hours, adding EDTA into the soaked carbomer solution, stirring uniformly to obtain a phase A, putting NP-700, dihydroxyaluminum and glycerol into a stainless steel large container, and stirring uniformly to obtain a phase B;
s4, adding the phase B into the phase A, placing in a vacuum stirrer, stirring to obtain paste, taking out the paste, coating the paste on a non-woven fabric bag, and placing at room temperature after coating, and naturally solidifying and forming the paste.
2. The external prescription for cervical and lumbar diseases according to claim 1, wherein: and (3) filtering the fine powder obtained in the step (S1) through a 100-150-mesh filter screen to obtain fine powder with a powder diameter of 100-150 mu m.
3. The external prescription for cervical and lumbar diseases according to claim 2, wherein: the stirring speed of the vacuum stirrer in the step S4 is 120-160 r/min, and the stirring time is about 5 min.
4. A cervical and lumbar vertebra disease external prescription according to claim 3, wherein: the external prescription comprises the following raw materials in parts by weight: 0.5 part of carbomer, 0.3 part of aluminum glycyrrhizate, 30 parts of glycerol, 0.01 part of EDTA, 0.05 part of citric acid, 35 parts of compound fine powder and 80 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 5.0 parts of mulberry twig, 5.0 parts of wormwood, 1.0 part of coconut shell, 1.0 part of morinda officinalis and 1.0 part of prepared fleece-flower root.
5. A cervical and lumbar vertebra disease external prescription according to claim 3, wherein: the external prescription comprises the following raw materials in parts by weight: 1.0 part of carbomer, 9.0 parts of NP-700, 0.5 part of aluminum glycyrrhizate, 50 parts of glycerin, 0.05 part of EDTA, 0.2 part of citric acid, 40 parts of compound fine powder and 90 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 6.5 parts of mulberry twig, 5.5 parts of wormwood, 1.5 parts of coconut shell, 1.5 parts of morinda officinalis and 1.5 parts of prepared fleece-flower root.
6. A cervical and lumbar vertebra disease external prescription according to claim 3, wherein: the external prescription comprises the following raw materials in parts by weight: 2.0 parts of carbomer, 10.0 parts of NP-700, 0.8 part of aluminum glycyrrhizate, 60 parts of glycerin, 0.07 part of EDTA, 0.3 part of citric acid, 50 parts of compound fine powder and 100 parts of water, wherein the compound fine powder comprises the following raw materials in parts by weight: 7.0 parts of mulberry twig, 6.0 parts of wormwood, 2.0 parts of coconut shell, 2.0 parts of morinda officinalis and 2.0 parts of prepared fleece-flower root.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210271512.6A CN114533805B (en) | 2022-03-18 | 2022-03-18 | External prescription for cervical vertebra and lumbar vertebra diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210271512.6A CN114533805B (en) | 2022-03-18 | 2022-03-18 | External prescription for cervical vertebra and lumbar vertebra diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114533805A CN114533805A (en) | 2022-05-27 |
| CN114533805B true CN114533805B (en) | 2024-02-02 |
Family
ID=81664797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210271512.6A Active CN114533805B (en) | 2022-03-18 | 2022-03-18 | External prescription for cervical vertebra and lumbar vertebra diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114533805B (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376500A (en) * | 2002-04-05 | 2002-10-30 | 刘德候 | Capsule 'Jingyaoning' and its preparing process |
| CN101513452A (en) * | 2009-03-24 | 2009-08-26 | 武汉理工大学 | Decumbent corydalis tuber cataplasm and preparation method thereof |
| CN102274342A (en) * | 2011-07-18 | 2011-12-14 | 张维夯 | External sticking plaster |
| CN102406840A (en) * | 2011-11-18 | 2012-04-11 | 云南省药物研究所 | Swelling and pain gel paste and preparation method thereof |
| CN103446407A (en) * | 2013-08-21 | 2013-12-18 | 兰州善元和蒸熏研究所 | Pure traditional Chinese medicine preparation for treating cervical spondylosis and lumbar spondylosis and fumigant of pure traditional Chinese medicine preparation |
| CN104288538A (en) * | 2014-10-15 | 2015-01-21 | 王新忠 | Plaster for treating neck, shoulder, waist and leg diseases and preparation method of plaster |
| CN104606411A (en) * | 2015-02-13 | 2015-05-13 | 朱福文 | Plaster for treating cervical and lumbar spondylosis and osteoarthritis |
| CN105168973A (en) * | 2015-09-09 | 2015-12-23 | 张敬东 | Traditional Chinese medicine for treating cervical spondylosis and lumbar spondylosis |
| WO2017129132A1 (en) * | 2016-01-28 | 2017-08-03 | 陈石全 | Healthcare hot compress chinese medicine bag and preparation method for same |
| CN108465025A (en) * | 2018-06-07 | 2018-08-31 | 邵小宁 | It is a kind of treat cervical spondylosis, lumbar vertebra disease Chinese medicine composition and preparation method thereof |
| CN114028507A (en) * | 2021-11-09 | 2022-02-11 | 广州医科大学附属中医医院 | Preparation method of traditional Chinese medicine for treating lumbago |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404480A (en) * | 2022-01-27 | 2022-04-29 | 山西同福仁康生物科技有限公司 | Muscle and bone joint plaster and preparation method thereof |
-
2022
- 2022-03-18 CN CN202210271512.6A patent/CN114533805B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376500A (en) * | 2002-04-05 | 2002-10-30 | 刘德候 | Capsule 'Jingyaoning' and its preparing process |
| CN101513452A (en) * | 2009-03-24 | 2009-08-26 | 武汉理工大学 | Decumbent corydalis tuber cataplasm and preparation method thereof |
| CN102274342A (en) * | 2011-07-18 | 2011-12-14 | 张维夯 | External sticking plaster |
| CN102406840A (en) * | 2011-11-18 | 2012-04-11 | 云南省药物研究所 | Swelling and pain gel paste and preparation method thereof |
| CN103446407A (en) * | 2013-08-21 | 2013-12-18 | 兰州善元和蒸熏研究所 | Pure traditional Chinese medicine preparation for treating cervical spondylosis and lumbar spondylosis and fumigant of pure traditional Chinese medicine preparation |
| CN104288538A (en) * | 2014-10-15 | 2015-01-21 | 王新忠 | Plaster for treating neck, shoulder, waist and leg diseases and preparation method of plaster |
| CN104606411A (en) * | 2015-02-13 | 2015-05-13 | 朱福文 | Plaster for treating cervical and lumbar spondylosis and osteoarthritis |
| CN105168973A (en) * | 2015-09-09 | 2015-12-23 | 张敬东 | Traditional Chinese medicine for treating cervical spondylosis and lumbar spondylosis |
| WO2017129132A1 (en) * | 2016-01-28 | 2017-08-03 | 陈石全 | Healthcare hot compress chinese medicine bag and preparation method for same |
| CN108465025A (en) * | 2018-06-07 | 2018-08-31 | 邵小宁 | It is a kind of treat cervical spondylosis, lumbar vertebra disease Chinese medicine composition and preparation method thereof |
| CN114028507A (en) * | 2021-11-09 | 2022-02-11 | 广州医科大学附属中医医院 | Preparation method of traditional Chinese medicine for treating lumbago |
Non-Patent Citations (4)
| Title |
|---|
| 中药热敷治疗颈、腰椎病116例;贾潮英;;中医外治杂志(第02期);第44-45页 * |
| 中药熏蒸、牵引联合手法推拿治疗椎动脉型颈椎病126例疗效观察;方英杰;陈小平;;山东医药;-;第-卷(第29期);第107-108页 * |
| 莫文运用调和气血法异病同治脊柱退行性疾病用药规律总结;薛瑞瑞;许金海;尹萌辰;邬学群;马俊明;叶洁;莫文;;山东中医杂志(第05期);第62-68页 * |
| 邓晋丰教授以通法治疗腰腿痛经验介绍;刘向前, 林定坤, 王羽丰, 邓晋丰;新中医(第06期);第13-14页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114533805A (en) | 2022-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102698079B (en) | Medicine composition for treating xerophthalmia and preparation method and application thereof | |
| CN100459958C (en) | Chinese medicine heat therapy eyeshade and its medicine | |
| CN104706820A (en) | Chinese herbal medicine containing eye-protecting tablet | |
| WO2008071075A1 (en) | A process for preparation of extract of broussonetia papyritera and the use thereof in manufacture of a medicament | |
| CN104173591B (en) | Pu-erh tea essential oil hydrogel plaster and preparation method thereof | |
| CN114533805B (en) | External prescription for cervical vertebra and lumbar vertebra diseases | |
| CN112121104B (en) | Traditional Chinese medicine composition for relieving asthenopia and preventing and treating myopia | |
| CN107625944A (en) | Warm application of a kind of ginger folium artemisiae argyi cervical vertebra and preparation method thereof | |
| CN114010591A (en) | Externally-applied traditional Chinese medicine gel paste for treating asthenopia and preparation method thereof | |
| CN110974935A (en) | Antibacterial nursing gel containing fullerene C60 component and preparation method thereof | |
| CN110025557A (en) | A kind of draft eye essence and preparation method thereof | |
| CN101185704B (en) | Powder agent medicine for treating aphtha | |
| CN111450213A (en) | Moxibustion heat treatment plaster for treating bone fracture diseases | |
| CN109223919A (en) | A kind of graphene precious jade medicine cover glass and preparation method thereof | |
| CN114949065A (en) | Traditional Chinese medicine application for treating early traumatic injury and preparation method thereof | |
| CN108524882A (en) | A kind of external application for curing wapperijaw facial paralysis pharmaceutical composition and its application and preparation method | |
| CN113274427A (en) | Eye protection patch with myopia prevention and control functions | |
| CN1098691C (en) | Propolis honey and its preparing process | |
| CN115779061A (en) | Traditional Chinese medicine composition for relieving allergic rhinitis and preparation method thereof | |
| CN118453481A (en) | Pouch-dispelling extract and preparation method and application thereof | |
| CN118717931A (en) | Traditional Chinese medicine composition for treating allergic rhinitis, patch and preparation method thereof | |
| CN116350707A (en) | Traditional Chinese medicine eye-protection paste stock solution and eye-protection paste | |
| CN108514612A (en) | A kind of cool liver, which relieves dizziness, high fever, infantile convulsions, epilepsy, etc., increases the Chinese medicine preparation of liquid relaxing muscles and tendons | |
| CN115475214A (en) | Eyesight-improving health-care paste and preparation method thereof | |
| CN117562877A (en) | Allergy-free ear patch and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |