CN114949065A - Traditional Chinese medicine application for treating early traumatic injury and preparation method thereof - Google Patents
Traditional Chinese medicine application for treating early traumatic injury and preparation method thereof Download PDFInfo
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- CN114949065A CN114949065A CN202210629741.0A CN202210629741A CN114949065A CN 114949065 A CN114949065 A CN 114949065A CN 202210629741 A CN202210629741 A CN 202210629741A CN 114949065 A CN114949065 A CN 114949065A
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- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine plaster for treating early traumatic injury, which consists of partially neutralized sodium polyacrylate, dihydroxyaluminium aminoacetate, sodium edetate, tartaric acid, glycerol, water, povidone, a menthol camphor composition, benzoic acid and traditional Chinese medicine components; wherein the Chinese medicinal components comprise radix et rhizoma Rhei, folium Platycladi, radix Paeoniae Rubra, radix Angelicae sinensis, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri. The traditional Chinese medicine hydrophilic plaster inherits the traditional theory of traditional Chinese medicine, combines with the new process and new technology of modern preparations, has low anaphylaxis, has the effects of both medicine treatment and cold compress physiotherapy, is suitable for treating early traumatic injury, and has wide application prospect and clinical value.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine application for treating early traumatic injury and a preparation method thereof.
Background
Nowadays, sports is more and more popular, wherein young people regard fitness sports as a fashion, but people injured by sports are more and more, and patients with local traumatic injuries in hospital visit are gradually younger. In China, up to 96.4% of running enthusiasts are injured during running, and the production scale of 2009, 2014 fitness industry shows that the exercise injury rate of people who exercise frequently reaches more than 85%. In terms of treatment methods, chronic and old injuries mainly take warm-heat tendon relaxing and activating, while early acute traumatic injuries mainly take cold-heat tendon relaxing, early traumatic injuries need to be treated in time, otherwise chronic injuries are easy to develop, and subsequent healthy life is influenced. However, the existing externally applied products for treating injuries in hospitals or markets are mostly directed at chronic injuries, and are not suitable for treating red and swollen masses appearing in early traumatic injuries. The Chinese medicinal patch for treating early traumatic injury is specially developed by combining years of clinical experience of Chinese medical doctors of the famous province Li Wanyi leading ren, and mainly treats early traumatic injury and local red swelling and hot pain; or initial sores, local mass formation without ulcers.
The application method of the traditional application in the hospital is that medical staff takes a proper amount of mixed medicinal powder, adds water and heats the mixed medicinal powder into paste to help the application, and patients need to go to the hospital every day for changing the medicine, which is very inconvenient, the dosage of the medicine is difficult to control, and in addition, the hot application is not suitable for part of patients with early injury.
The traditional Chinese medicine hydrophilic plaster inherits the traditional theory of traditional Chinese medicine, combines with the new process and the new technology of the modern preparation, and is not disclosed with the research of the preparation process and the quality standard which are the same as those of the composition after looking up the relevant literature data, thereby having wide application prospect and clinical value.
Disclosure of Invention
In order to solve the technical problems, the invention aims to disclose a traditional Chinese medicine application for treating early traumatic injury and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows: a composition for the treatment of early traumatic injury comprises radix et rhizoma Rhei, folium Platycladi, radix Paeoniae Rubra, radix Angelicae sinensis, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri.
Preferably, the traditional Chinese medicine composition consists of, by mass, 4-8 parts of rhubarb, 1-3 parts of cacumen biotae, 2-6 parts of red paeony root, 2-4 parts of angelica tail, 2-6 parts of herba lycopi, 1-2 parts of safflower, 1-4 parts of mint and 2-6 parts of golden cypress.
A Chinese medicinal patch for the treatment of early traumatic injury comprises partially neutralized sodium polyacrylate, dihydroxyaluminium aminoacetate, edetate sodium, tartaric acid, glycerol, water, polyvidone, Mentholum Camphora composition, benzoic acid and Chinese medicinal components; wherein the Chinese medicinal components comprise radix et rhizoma Rhei, folium Platycladi, radix Paeoniae Rubra, radix Angelicae sinensis, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri.
Preferably, the traditional Chinese medicine patch comprises 5-8% of partially neutralized sodium polyacrylate, 0.1-0.5% of dihydroxyaluminum, 0.05-0.3% of sodium edetate, 0.1-0.6% of tartaric acid, 20-35% of glycerol, 35-50% of water, 0.5-2% of polyvidone, 1-5% of menthol camphor composition, 0.1-0.3% of benzoic acid and traditional Chinese medicine components.
Preferably, the traditional Chinese medicine components comprise, by mass, 4-8 parts of rheum officinale, 1-3 parts of cacumen biotae, 2-6 parts of radix paeoniae rubra, 2-4 parts of angelica tail, 2-6 parts of herba lycopi, 1-2 parts of safflower, 1-4 parts of mint and 2-6 parts of cortex phellodendri.
Preferably, the menthol camphor composition comprises the following components in percentage by mass: camphor 1:0.2 to 1.
A preparation method of a traditional Chinese medicine patch for treating early traumatic injury comprises the following steps: 1) pulverizing radix et rhizoma Rhei, radix Angelicae sinensis and radix Paeoniae Rubra into fine powder; 2) percolating cacumen Platycladi, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri with 80-90% ethanol, collecting percolate, and concentrating to obtain extract with density of 1.05-1.10 to obtain extract 1; 3) decocting the residue with water, collecting water extractive solution, and concentrating to obtain extract with density of 1.05-1.10 to obtain extract 2;
4) combining the fine powder with extract 1 and extract 2; 5) dissolving the product obtained in the step 4) with tartaric acid, edetate disodium and benzoic acid in water to be used as an A phase; 6) dissolving menthol and camphor, adding into glycerol, adding partially neutralized sodium polyacrylate, dihydroxyaluminum glycolate and polyvidone, dispersing in glycerol, and mixing to obtain phase B; 7) adding phase B into phase A, mixing to obtain hydrophilic paste, coating on non-woven fabric, covering with polyethylene film, and standing at room temperature for 1-2 weeks.
Preferably, the preparation method of the extract 1 comprises the following steps: pulverizing cacumen biotae, herba lycopi, safflower, mint and golden cypress into coarse powder, and soaking the coarse powder in 80-90% ethanol in an amount which is 3 times that of the coarse powder for 12-24 hours to ensure that a solvent is fully permeated and diffused; opening a percolate outlet to receive percolate, continuously supplementing a solvent in the percolation process at the outflow speed of 1-3 ml per minute to enable the solvent to be immersed in the medicinal powder all the time, and percolating for 48 hours; collecting percolate, and concentrating under reduced pressure at 40-50 deg.C until the density of extract is 1.05-1.10.
Preferably, the preparation method of the extract 2 comprises the following steps: and (3) taking the residues after percolation, volatilizing ethanol, adding water which is 8 times of the amount of the residues for extraction twice, extracting for 2 hours, collecting decoction of the two times, uniformly mixing, and concentrating under reduced pressure at 60-70 ℃ until the density of the extract is 1.05-1.10 to obtain the traditional Chinese medicine.
A Chinese medicinal plaster matrix for treating early traumatic injury comprises partially neutralized sodium polyacrylate, aluminum glycollate, edetate sodium, tartaric acid, glycerol, water, polyvidone, Mentholum Camphora composition, and benzoic acid.
The traditional Chinese medicine hydrophilic plaster has the advantages that the traditional theory of traditional Chinese medicine is inherited, the new process and the new technology of the modern preparation are combined, the anaphylaxis is low, the effects of medicine treatment and cold compress physiotherapy are achieved, the traditional Chinese medicine hydrophilic plaster is suitable for treating early traumatic injury, and the traditional Chinese medicine hydrophilic plaster has wide application prospect and clinical value.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
Example 1
The traditional Chinese medicine patch is prepared by the following method:
1) preparation of Chinese medicinal composition
The prescription consists of eight traditional Chinese medicines, namely rhubarb, cacumen biotae, red paeony root, angelica tail, herba lycopi, safflower, mint, golden cypress and the like. A part of the medicines in the prescription is directly pulverized and added into the medicine, and a part of the medicines is added into the medicine after being extracted by alcohol and water. Wherein, the rhubarb, the angelica tail and the red paeony root are crushed into fine powder, the cacumen biotae, the herba lycopi, the safflower, the mint and the golden cypress are firstly percolated by 80 to 90 percent ethanol, and the percolated liquid is collected and concentrated into an extract with the density of 1.05 to 1.10 to obtain an extract 1; decocting the residue with water, collecting water extractive solution, and concentrating to obtain extract with density of 1.05-1.10 to obtain extract 2. Mixing the fine powder with extract 1 and extract 2.
2) Preparation of paste
Dissolving the traditional Chinese medicine composition, tartaric acid, edetate disodium and benzoic acid in the prescription amount in water to be used as an A phase; dissolving menthol and camphor, adding into glycerol, adding partially neutralized sodium polyacrylate, dihydroxyaluminum glycolate and polyvidone, dispersing in glycerol, and mixing to obtain phase B; adding phase B into phase A, mixing to obtain hydrophilic paste, coating on non-woven fabric, covering with polyethylene film, and standing at room temperature for 1-2 weeks.
Example 2
And carrying out process optimization by adopting an orthogonal test. The method comprises the following specific steps:
powder: according to the mass parts, 8 portions of rhubarb, 2 portions of angelica tail and 3 portions of red peony root are taken and crushed into powder with the granularity of more than 100 meshes.
Extract 1: according to the mass parts, 3 parts of cacumen biotae, 4 parts of herba lycopi, 1 part of safflower, 4 parts of mint and 4 parts of cortex phellodendri are taken, crushed into coarse powder, and soaked in 80-90% ethanol in an amount which is 3 times that of the coarse powder for 12-24 hours, so that the solvent is fully permeated and diffused. And opening a percolate outlet to receive the percolate, wherein the outflow speed of the percolate is 1-3 ml per minute, continuously supplementing the solvent in the percolation process, and enabling the solvent to be immersed in the medicinal powder all the time, wherein the percolation time is 48 hours. Collecting percolate, and concentrating under reduced pressure at 40-50 deg.C until the density of extract is 1.05-1.10.
And (2) extraction: and (3) taking the residues after percolation, volatilizing ethanol, adding water which is 8 times of the amount of the residues for extraction twice, extracting for 2 hours, collecting decoction of the two times, uniformly mixing, and concentrating under reduced pressure at 60-70 ℃ until the density of the extract is 1.05-1.10 to obtain the traditional Chinese medicine.
Selecting main matrix, partially neutralizing sodium polyacrylate, aluminum glycollate, edetate disodium, tartaric acid, and polyvidone, and optimizing by test method according to orthogonal design table L 16 (3 4 ) The experiment is arranged, see the 'factor level table' in the table, and the rest components are added according to 35% of glycerin, 35% of water, 2% of menthol camphor composition (1: 0.2-1), 0.2% of benzoic acid and 18.8% of traditional Chinese medicine composition.
The preparation method comprises the following steps: dissolving the traditional Chinese medicine composition, tartaric acid, edetate disodium and benzoic acid in the prescription amount in water to be used as an A phase; dissolving menthol and camphor, adding into glycerol, adding partially neutralized sodium polyacrylate, dihydroxyaluminum glycolate and polyvidone, dispersing in glycerol, and mixing to obtain phase B; adding phase B into phase A, mixing to obtain hydrophilic paste, coating on non-woven fabric, covering with polyethylene film, and observing. And selecting the preparation method parameters by taking the comprehensive score of the sensory evaluation as a survey index. The results are shown in the table "orthogonal test results".
Table combined sensory scoring specifications
Remarking: the sensory corresponding scores were "good" 10 points, "normal" 8 points, "normal" 6 points, "poor" 5 points, "poor" 3 points, "no such property" 0 points.
Table factor level table
Results of the Table Quadrature test
As is clear from the results in the table, A 2 B 4 C 2 D 3 E 3 The combination is a combination with a higher score, the worst difference is sodium polyacrylate and aluminum glycoxide, namely the sodium polyacrylate and the aluminum glycoxide which have the greatest influence on the process are partially neutralized.
Through verification, the plaster prepared by the optimized process has the use characteristics of good viscosity, no residue, skin fitting and repeated uncovering, and the experience of a patient when the plaster is used is obviously improved.
The best mixture ratio through research is as follows: 7.2% of partially neutralized sodium polyacrylate, 0.3% of dihydroxyaluminium glycolate, 0.1% of edetate disodium, 0.4% of tartaric acid, 35% of glycerol, 35% of water, 2% of povidone, 2% of menthol camphor composition (1: 0.2-1), 0.2% of benzoic acid and 18.8% of traditional Chinese medicine composition.
Example 3
The hydrophilic Chinese medicinal plaster of example 2 is used for treating early traumatic injury, and has the functions of medicament treatment and cold compress physical therapy. The design experiment compares the cooling condition of the self-made hydrophilic traditional Chinese medicine plaster and the commercially available plaster (taking rubber plaster as an example) in the research.
In an incubator at 39 ℃. + -. 2 ℃ 1 thermometer was placed. When the thermometer reaches the target temperature Ta of 39 ℃, wrapping a mercury head of the thermometer by using hydrophilic Chinese medicine plaster, reading the temperatures displayed by the thermometer at 1h, 2h, 3h, 4h, 5h, 6h, 7h and 8h to be Tbi respectively, calculating the temperature reduction performance Ti-Tbi | and calculating the average value delta T ═ T (T1+ T2+ · + T8)/8 (wherein the units of Tbi, Ti and delta T are all DEG C, i is 1-8).
The result shows that the self-made hydrophilic Chinese medicinal plaster can be cooled for at least 8h and 2.5 ℃. The commercially available plaster (rubber plaster for example) has no cooling effect.
Temperature record of table cooling experiment
Example 4
The hydrophilic Chinese medicinal plaster in example 2 is mainly used for treating red swelling and pain in early traumatic injury. The selected patients have clinical manifestations of sprain, contusion, muscle and tendon swelling and pain, such as local redness, swelling, heat, pain and the like, and meanwhile, the skin of the pain part is not damaged, the history of drug allergy is avoided, and the routine examination is normal. The above 20 cases are used for the observation of the curative effect of detumescence and acesodyne.
4.1 test method
The self-made hydrophilic Chinese medicinal plaster is applied to the affected part for 3 days every 4 h.
4.2 evaluation of therapeutic Effect
Therapeutic effect evaluation observation table
Evaluation results of therapeutic effects
The clinical observation results show that the self-made hydrophilic traditional Chinese medicine plaster can effectively relieve pain and detumescence.
Example 5
Further research is carried out on the specific proportion of the traditional Chinese medicine (by mass parts), and different prescriptions are matched according to the following table: and a Chinese medicinal patch was prepared according to the method of example 1.
Watch formula
Qualified mice were screened, randomly grouped (10 per group) with 24h abdominal hair removal before dosing, and 24h abdominal hair removal before dosing. Respectively sticking the traditional Chinese medicines of the formulas 1-5 for external application; the test is carried out 12 hours before the test without food, water is freely drunk, xylene is coated on the front and back surfaces of the right ear of the mouse after the last administration for 60 minutes, 50uL of xylene is used for each mouse, the cervical vertebra of the mouse is dislocated after 30 minutes, two ears are cut along the auricle base line, round ear pieces are respectively cut at the same part by a 9mm puncher, the round ear pieces are respectively precisely weighed by an electronic balance, and the swelling inhibition rate is calculated, wherein the swelling degree is the weight of the right ear piece-the weight of the left ear piece. The results of the experiments are shown in the following table:
while the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A composition for treating early traumatic injury is characterized by comprising rheum officinale, cacumen biotae, red paeony root, angelica tail, herba lycopi, safflower, mint and golden cypress.
2. The traditional Chinese medicine patch as claimed in claim 1, wherein the traditional Chinese medicine composition comprises, by mass, 4-8 parts of rhubarb, 1-3 parts of cacumen biotae, 2-6 parts of radix paeoniae rubra, 2-4 parts of angelica tail, 2-6 parts of herba lycopi, 1-2 parts of safflower, 1-4 parts of mint and 2-6 parts of cortex phellodendri.
3. A traditional Chinese medicine plaster for treating early traumatic injury is characterized in that the traditional Chinese medicine plaster is composed of partially neutralized sodium polyacrylate, dihydroxyaluminum glycinate, sodium edetate, tartaric acid, glycerin, water, povidone, menthol camphor composition, benzoic acid and traditional Chinese medicine components; wherein the Chinese medicinal components comprise radix et rhizoma Rhei, folium Platycladi, radix Paeoniae Rubra, radix Angelicae sinensis, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri.
4. The traditional Chinese medicine patch as claimed in claim 3, wherein the traditional Chinese medicine patch comprises 5-8% of partially neutralized sodium polyacrylate, 0.1-0.5% of dihydroxyaluminum glycinate, 0.05-0.3% of sodium edetate, 0.1-0.6% of tartaric acid, 20-35% of glycerin, 35-50% of water, 0.5-2% of povidone, 1-5% of menthol camphor composition, 0.1-0.3% of benzoic acid and traditional Chinese medicine components.
5. The traditional Chinese medicine patch as claimed in claim 3, wherein the traditional Chinese medicine components comprise, by mass, 4-8 parts of rhubarb, 1-3 parts of cacumen biotae, 2-6 parts of radix paeoniae rubra, 2-4 parts of angelica sinensis, 2-6 parts of herba lycopi, 1-2 parts of safflower, 1-4 parts of mint and 2-6 parts of cortex phellodendri.
6. The traditional Chinese medicine patch as claimed in claim 3, wherein the menthol camphor composition comprises, by mass, mint: camphor 1:0.2 to 1.
7. A preparation method of a traditional Chinese medicine patch for treating early traumatic injury comprises the following steps: 1) pulverizing radix et rhizoma Rhei, radix Angelicae sinensis and radix Paeoniae Rubra into fine powder; 2) percolating cacumen Platycladi, herba Lycopi, Carthami flos, herba Menthae, and cortex Phellodendri with 80-90% ethanol, collecting percolate, and concentrating to obtain extract with density of 1.05-1.10 to obtain extract 1; 3) decocting the residue with water, collecting water extractive solution, and concentrating to obtain extract with density of 1.05-1.10 to obtain extract 2; 4) combining the fine powder with extract 1 and extract 2; 5) dissolving the product obtained in the step 4) with tartaric acid, edetate disodium and benzoic acid in water to be used as an A phase; 6) dissolving menthol and camphor, adding into glycerol, adding partially neutralized sodium polyacrylate, dihydroxyaluminum glycolate and polyvidone, dispersing in glycerol, and mixing to obtain phase B; 7) adding phase B into phase A, mixing to obtain hydrophilic paste, coating on non-woven fabric, covering with polyethylene film, and standing at room temperature for 1-2 weeks.
8. The method for preparing the extract 1 according to claim 6, wherein the method for preparing the extract 1 comprises: pulverizing cacumen biotae, herba lycopi, safflower, mint and golden cypress into coarse powder, and soaking the coarse powder in 80-90% ethanol in an amount which is 3 times that of the coarse powder for 12-24 hours to ensure that a solvent is fully permeated and diffused; opening a percolate outlet to receive percolate, continuously supplementing a solvent in the percolation process at the outflow speed of 1-3 ml per minute to enable the solvent to be immersed in the medicinal powder all the time, and percolating for 48 hours; collecting percolate, and concentrating under reduced pressure at 40-50 deg.C until the density of extract is 1.05-1.10.
9. The method of claim 6, wherein the extract 2 is prepared by: and (3) taking the residues after percolation, volatilizing ethanol, adding water which is 8 times of the amount of the residues for extraction twice, extracting for 2 hours, collecting decoction of the two times, uniformly mixing, and concentrating under reduced pressure at 60-70 ℃ until the density of the extract is 1.05-1.10 to obtain the traditional Chinese medicine.
10. A traditional Chinese medicine plaster matrix for treating early traumatic injury is characterized in that the matrix is composed of partially neutralized sodium polyacrylate, dihydroxyaluminum glycolate, sodium edetate, tartaric acid, glycerin, water, povidone, a menthol camphor composition and benzoic acid.
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| CN1541666A (en) * | 2003-04-29 | 2004-11-03 | 深圳市东方本草科技开发有限公司 | Chinese traditional medicine composition for treating bedsore and acute soft tissue injury |
| CN101385798A (en) * | 2008-10-17 | 2009-03-18 | 植秋娴 | Wind dispelling and pain relieving paste for treating hyperostegeny |
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