CN113274427A

CN113274427A - Eye protection patch with myopia prevention and control functions

Info

Publication number: CN113274427A
Application number: CN202110597434.4A
Authority: CN
Inventors: 杨唯宁; 陈伟华
Original assignee: Shanghai Linyuan Medical Technology Co ltd
Current assignee: Shanghai Linyuan Medical Technology Co ltd
Priority date: 2021-05-31
Filing date: 2021-05-31
Publication date: 2021-08-20

Abstract

The invention discloses an eye protection patch with myopia prevention and control functions, which takes natural hydrogel as a carrier, and the components attached in the natural hydrogel comprise borneol, an extract of abalone shell, and a mixed extract of cicada slough and buddleja officinalis. The eye patch designed by the invention contains compatible traditional Chinese medicine components, and plays a drug effect by stimulating Jingming, Sibai and Taiyang acupoints around eyes. The eye patch does not contact eyelids, and the user can normally use eyes during the use process. The eye patch solves the problem that the eye patch can not normally use the eyes in the prior art, can enable a user to normally work or learn while applying the eyes, has a TDDS skin administration function by taking pure natural sodium alginate hydrogel as a carrier, has stronger skin affinity, is safe and harmless, can be used by teenagers, greatly prolongs the service time of the eye patch, and improves the stimulation effect of the eye patch on acupuncture points.

Description

Eye protection patch with myopia prevention and control functions

Technical Field

The invention belongs to the technical field of medical supplies, relates to an eye protection patch, and particularly relates to an eye protection patch with a myopia prevention and control function.

Background

Myopia is a global public health problem and social problem and presents an increasing trend year by year. As society develops, the prevalence of myopia will further increase. Myopia, especially pathological myopia, is often accompanied by serious ocular complications, such as a series of pathological changes of retinal choroidal atrophy, retinal detachment, glaucoma and the like, which cause poor vision and even blindness, is the leading factor of low vision in China and one of the main causes of blindness, seriously affects the life quality of patients, and brings great burden to families and society of the patients. Therefore, prevention and treatment of myopia is an important public health problem to be solved urgently. WTOs have also listed near vision as a global anti-blindness program. In 2018, eight departments, such as education department, national health committee and the like, implement the comprehensive prevention and control scheme for the myopia of the children and the teenagers, and the myopia prevention and control of the teenagers is promoted to be a national strategy. Therefore, the myopia of the teenagers can be prevented and controlled, and the myopia is not easy to be controlled. At present, few effective prevention and control means aiming at myopia exist, and the existing technology and method cannot effectively inhibit the trend of gradually rising myopic prevalence rate, so that a new means or method is urgently needed.

The history of traditional Chinese medicine treatment of myopia is long, and various reports of myopia prevention and control by using traditional Chinese medicine therapy including traditional Chinese medicine oral administration, traditional Chinese medicine fumigation, traditional Chinese medicine application, acupuncture and moxibustion and the like are proved to be capable of delaying the development of myopia to a certain extent. The method not only has the internal and/or external application of the medicine, but also has the acupuncture point stimulation, which indicates that the acupuncture point stimulation (acupuncture or medicine) is one of effective means. However, the above methods are all professional and need to be completed by doctors at regular intervals in hospitals, and the myopia patients or family members cannot insist for a long time, so a simple, effective, convenient and long-term use method is urgently needed.

At present, common administration routes comprise oral administration, intravenous administration, intramuscular injection administration, inhalation administration, conjunctival administration, transdermal administration and the like, wherein the transdermal administration brings great convenience to patients and remarkably relieves the pain of the patients. Compared with the traditional oral administration or injection administration, the transdermal administration has a plurality of advantages, avoids the low efficiency and side effect of oral administration, has the high efficiency of injection administration, has the convenience, safety and compliance of a transdermal patch, can realize the synergistic effect of a plurality of medicines, and has small administration side effect.

The eye patch is a film which is similar to a band-aid and is created for treating certain diseases of eyes or solving the problem of eye skin, the eye patch can contain traditional Chinese medicine components, and the traditional Chinese medicine components are applied to the eyes to enable the medicine to be absorbed through the eye skin so as to treat or relieve the eye problem.

According to the components of the eye patch, the current eye patch with the myopia prevention and control effect mainly comprises the following categories: the first type is a cold compress type eye patch which is formed by directly soaking traditional Chinese medicines in non-woven fabrics and applying the non-woven fabrics to the skin around eyes in a wet manner; the second type is that non-woven fabric is used as a base material, and macromolecule polyvinyl alcohol gel mixed with traditional Chinese medicine components is smeared on the surface of the base material; the third type is a hot compress type eye patch, which uses self-heating materials to promote the absorption of the traditional Chinese medicine components by skin in a hot compress mode and improve the utilization rate of the medicine.

The existing eye patch patent is designed to overcome the defect that the eye patch cannot be tightly attached to the skin, and also has the design of increasing the medicine absorption efficiency by increasing the temperature, and the design of reducing the oppression of the eye patch on eyeballs by changing the appearance of the eye patch, and in addition, the eye patch specially stimulates acupuncture points around the eyes. Through the design, the design of the eye patch is gradually improved.

For example, the chinese patent application discloses an eye-protecting patch (grant publication No. CN204446279U) for protecting eyesight, which is a design for simultaneously applying both eyes, and is designed to have the effect of stimulating more acupuncture points, and around the eye-protecting patch, some scattered protrusions are specially designed to better cover the acupuncture points; in addition, the eye patch is designed with an inward concave shape in order to stimulate the Jingzhu point and the Jingming point at the nasal side. Through the improvement of the design, the eye patch has larger area, can not slide off, and can stimulate acupuncture points around eyes more effectively.

For another example, the chinese patent application also discloses that an eye protection patch (grant publication No. CN205144851U) for improving eyesight also makes some improvements in appearance and function. The eye patch is a hot compress type eye patch, on one hand, eye fatigue can be relieved by hot compress, and on the other hand, the absorption rate of the traditional Chinese medicine by the skin of the traditional Chinese medicine components under the action of hot compress is higher. Because the heating layer is arranged in the isolation layer during the patent design, the protection layer is also arranged, so that the safety is higher. The patent has additionally designed handheld position on structural design, avoids because of the bacterium infection eye of direct contact application paste face leading to the hand. The eye patch has local bulges, so that the eye patch can be prevented from directly pressing eyeballs. Crescent design accords with the physiology curve of eye, and the laminating effect is better.

The two eye patches are made of conventional non-woven fabrics, and are applied to the skin after being soaked by liquid, the liquid and the skin generate adhesion force, so that the eye patches can stimulate acupuncture points around eyes, but the defects are very obvious, for example, the eye patches are not tightly applied to the skin, the medicine penetrability is weak, the adhesion time is short, the curative effect of the eye patches is greatly reduced, and the medicine easily enters eyes to cause infection or allergy and the like due to more liquid.

Disclosure of Invention

The invention aims to provide an eye protection patch with myopia prevention and control functions for solving the technical problems.

The invention creatively provides an eye protection paste with myopia prevention and control functions, which takes natural hydrogel as a carrier, and the components attached in the natural hydrogel comprise borneol, an extract of abalone shell, and a mixed extract of cicada slough and buddleja officinalis.

In the eye protection patch with the myopia prevention and control function, the natural hydrogel contains natural sodium alginate.

In the eye patch with the myopia prevention and control function, the natural hydrogel further comprises sodium glycerophosphate, polyvinyl alcohol and chitosan.

In the eye patch with the myopia prevention and control function, the natural hydrogel comprises the following attached components in parts by weight:

0.5 to 0.8 portion of borneol,

the abalone shell extract is obtained by extracting 9-10 parts of abalone shell,

the mixed extract of the cicada slough and the buddleja officinalis is obtained by mixing and extracting 6-9 parts of cicada slough and 9-10 parts of buddleja officinalis.

In the eye protection patch with the myopia prevention and control function, the natural hydrogel comprises, by weight, 4-5 parts of natural sodium alginate, 6-8 parts of sodium glycerophosphate, 6-8 parts of polyvinyl alcohol and 2-4 parts of chitosan.

In the eye protection patch with the myopia prevention and control function, the eye protection patch is divided into a Jingming point eye patch, a Sibai point eye patch and a Taiyang point eye patch which are separated;

the Jingming acupoint eye plaster comprises a rectangular part and a semicircular part arranged on one side of the rectangular part;

the four-white acupoint eye patch is in a strip shape with two arc ends;

the temple eye patch is round.

In an above-mentioned eye-protecting subsides with myopia prevention and control function, eye-protecting subsides formula eye-protecting as an organic whole is pasted including being used for pasting in rectangular portion of four white acupuncture points department, bends to form along the one end of this rectangular portion and is used for pasting in the kink of Jingming acupuncture point department, bends along this rectangular portion other end curved shape and forms at the tip and be used for pasting in the circular portion of temple department.

In the eye protection patch with the myopia prevention and control function, the central position of the semicircular part of the eye patch at the Jingming point, the middle position of the eye patch at the Sibai point and the central position of the eye patch at the Taiyang point are respectively provided with a gentle convex part, the middle of the convex part is provided with a cavity, and the height of the convex part is 0.1-1.5 mm.

In the eye protection patch with the myopia prevention and control function, the preparation method comprises the following steps:

1) grinding Concha Haliotidis, adding into water, ultrasonic pulverizing, decocting with water, removing residue, collecting decoction, and cooling to obtain Concha Haliotidis extract;

2) grinding periostracum Cicadae and flos Buddlejae, adding into water, ultrasonic pulverizing, decocting, removing residues, and collecting juice to obtain mixed extract of periostracum Cicadae and flos Buddlejae;

3) uniformly stirring the abalone shell extract, the mixed extract of the cicada slough and the buddleja officinalis, grinding borneol into powder, adding the powder, and uniformly stirring again to obtain a mixed solution of the traditional Chinese medicine extract;

4) adding the natural hydrogel into the mixed solution of the traditional Chinese medicine extracts while stirring, and pouring the mixture into a forming die to obtain the eye-protecting patch.

1) grinding and crushing concha haliotidis according to a set amount, putting 100 parts of water into the crushed concha haliotidis for 5-10 min, adding 400 parts of water into the crushed concha haliotidis, boiling the crushed concha haliotidis, decocting the crushed concha haliotidis for 0.5-1 h by strong fire, decocting the crushed concha haliotidis for 1-2 h by slow fire, removing residues, taking juice and cooling the juice to obtain a concha haliotidis extract for later use;

2) weighing periostracum Cicadae and flos Buddlejae according to a set amount, mixing, grinding and crushing, adding water with the content of the periostracum Cicadae and flos Buddlejae being 4 times that of the flos Buddlejae, ultrasonically crushing for 5-10 min, heating and boiling, decocting for 10-20 min with slow fire, removing residues, taking juice to obtain a decoction, re-decocting the decoction and an equal amount of clear water for 10-20 min, removing residues, taking juice, and cooling to obtain a mixed extract of the periostracum Cicadae and the flos Buddlejae for later use;

3) uniformly stirring the abalone shell extract, the mixed extract of the cicada slough and the buddleja officinalis, grinding a certain amount of borneol into powder, adding the powder, and uniformly stirring the powder again to obtain a mixed solution of the traditional Chinese medicine extract;

4) adding natural sodium alginate, sodium glycerophosphate, polyvinyl alcohol and chitosan according to a set amount while stirring the mixed solution of the traditional Chinese medicine extract, pouring the mixture into a forming die, and performing irradiation crosslinking sterilization treatment to obtain the eye protection patch.

Compared with the prior art, the invention has the following beneficial effects:

the eye patch designed by the invention contains compatible traditional Chinese medicine components, and plays a drug effect by stimulating Jingming, Sibai and Taiyang acupoints around eyes. The eye patch does not contact eyelids, and the user can normally use eyes during the use process. The eye patch solves the problem that the eye can not be used normally when the eye patch is used in the past, and can enable a user to work normally or learn to use while applying eyes. The pure natural sodium alginate hydrogel is used as a carrier, has a TDDS skin administration function, has stronger skin affinity, is safe and harmless, can be used by teenagers, greatly prolongs the service time of the eye patch, and improves the stimulation effect of the eye patch on acupuncture points.

The eye protection patch provided by the invention can not directly contact eyelids, and the traditional Chinese medicine components are positioned in the hydrogel and can not flow out, so that eyeball irritation symptoms can be avoided, the eye protection patch has better subjective feeling and fewer side effects when in use.

The eye protection patch provided by the invention has the advantages that the area is reduced through a split type design, the raw materials can be saved to the maximum extent, and the waste is avoided.

Through being equipped with hollow convex part in the eyeshield pastes, increase the massage effect to the acupuncture point, promote skin to the absorption of medicine to compare in traditional transdermal subsides and acupuncture point and apply ointment or plaster, can increase the suitability with skin, soft and have the comfort level, the degree of compliance is good, is fit for long-term the use. By applying on skin, the Chinese medicinal composition can rapidly and durably penetrate into skin acupoints to achieve the effect of targeted stimulation of the acupoints.

The traditional Chinese medicine preparation is subjected to ultrasonic crushing and wall breaking, more organic components in cells are released, and the effective medicine concentration is higher. The eye protection patch provided by the invention has a certain help effect on myopia prevention and control, and has better clinical application prospect and social value.

The traditional Chinese medicine composition has the following specific effects:

the natural borneol not only has the effects of inducing resuscitation, refreshing mind, clearing heat, removing toxicity, improving eyesight and removing nebula, but also has stronger skin penetrating capability, and can improve the skin penetrating efficiency and the absorption availability of other traditional Chinese medicines.

Concha Haliotidis has effects of suppressing hyperactive liver, subsiding yang, removing heat, and improving eyesight.

Ci tui is sweet and cold in nature and can improve vision and remove nebula for treating wind-heat block with its qi purging and deficiency.

Flos Buddlejae is sweet and cold, enters liver channel, and has effects of nourishing liver blood to moisten dryness, clearing liver heat to improve eyesight, clearing heat, dispelling pathogenic wind, cooling blood, moistening liver, and improving eyesight.

The cicada slough and the buddleja officinalis are mixed and decocted, so that the cicada slough and the buddleja officinalis are mutually fused in the wall breaking process to fully play the synergistic effect of the composite components, and the eyesight improving effect is improved.

Traditional Chinese medicine considers that liver blood is injured by long-term vision, and myopia is caused by liver blood deficiency due to liver resuscitation in eyes. The compatibility of the traditional Chinese medicines is administrated through skin, so that the skin penetration capacity of the medicine can be improved, and the effects of clearing liver and improving vision, relieving eye fatigue and preventing and controlling myopia are stronger.

Because the active ingredients in the traditional Chinese medicine exist in cytoplasm and nucleus, the traditional decoction has weak effect of damaging cell walls, the extracted traditional Chinese medicine ingredients are very limited, and the discarded traditional Chinese medicine residues still contain more active ingredients, thereby causing great waste. Therefore, the cell walls are damaged before decoction, so that the traditional Chinese medicine components in the medicinal materials can be obtained to the maximum extent, the extraction rate of the traditional Chinese medicine is improved, the efficacy of the traditional Chinese medicine is improved, and the waste is reduced. Therefore, the invention uses the ultrasonic crushing technology to carry out ultrasonic crushing and wall breaking treatment on part of the traditional Chinese medicines, thereby improving the concentration of the traditional Chinese medicine components of the eye patch and improving the curative effect of the eye patch.

Drawings

Fig. 1 is a schematic structural diagram in an embodiment provided in the present application.

Fig. 2 is a schematic structural diagram of another embodiment provided in the present application.

Fig. 3 is a schematic structural diagram of another embodiment provided in the present application.

Fig. 4 is a schematic partial cross-sectional structure provided in the present application.

Detailed Description

The invention is further illustrated by the following examples:

example 1

An eye protection patch with myopia prevention and control functions comprises the following raw materials in parts by weight:

0.5 part of borneol, 6 parts of cicada slough, 10 parts of abalone shell, 10 parts of buddleia, 5 parts of natural sodium alginate, 6 parts of sodium glycerophosphate, 6 parts of polyvinyl alcohol and 2 parts of chitosan,

the preparation method comprises the following steps:

1) grinding and crushing concha haliotidis according to a set amount, putting 100 parts of water into the crushed sea-ear shell, performing ultrasonic crushing for 5min, then adding 400 parts of water, heating and boiling the mixture, decocting the mixture for 1h by strong fire, then decocting the mixture for 1-2 h by slow fire, removing residues, taking juice, and cooling the juice to room temperature to obtain a concha haliotidis extract for later use;

2) weighing periostracum Cicadae and flos Buddlejae according to a set amount, mixing, grinding and crushing, adding water with the content of the periostracum Cicadae and flos Buddlejae being 4 times that of the flos Buddlejae, ultrasonically crushing for 5min, heating and boiling, decocting for 10-20 min with slow fire, removing residues, taking juice to obtain decoction, re-decocting the decoction and an equal amount of clear water for 10-20 min, removing residues, taking juice, and cooling to room temperature to obtain a mixed extract of the periostracum Cicadae and the flos Buddlejae for later use;

3) mixing Concha Haliotidis extract with periostracum Cicadae and flos Buddlejae mixed extract, stirring, grinding Borneolum into powder, and stirring to obtain Chinese medicinal extract mixture;

4) adding natural sodium alginate, sodium glycerophosphate, polyvinyl alcohol and chitosan according to a set amount while stirring the mixed solution of the traditional Chinese medicine extract, pouring the mixture into a forming mould, and performing irradiation crosslinking sterilization treatment to obtain the eye protection patch.

As shown in fig. 1, the eye protection patch of this embodiment is divided into eye patch 1, eye patch 2 and eye patch 3, which are eye patches for Jingming, Sibai and Taiyang. The Jingming point eye patch 1 comprises a rectangular part 10 with the length of 2cm and the width of 1cm and a semicircular part 11 which is arranged at the center of the long side of one side of the rectangular part 10 and has the radius of 0.5 cm. The four-white acupoint eye patch 2 is a strip with two ends in arc shapes, the length of the strip is 3cm, the width of the strip is 1cm, and the radius of the arc at the two ends is 0.5 cm. The temple eye patch 3 is circular with a radius of 0.5 cm.

Example 2

0.5 part of borneol, 9 parts of cicada slough, 9 parts of abalone shell, 9 parts of buddleia officinalis, 4 parts of natural sodium alginate, 8 parts of sodium glycerophosphate, 8 parts of polyvinyl alcohol and 4 parts of chitosan,

the procedure for its preparation is as in example 1 below.

Example 3

0.8 part of borneol, 8 parts of cicada slough, 9 parts of abalone shell, 9 parts of buddleia officinalis, 4.5 parts of natural sodium alginate, 7 parts of sodium glycerophosphate, 7 parts of polyvinyl alcohol and 3 parts of chitosan,

the procedure for its preparation is as in example 1 below.

Example 4

This embodiment is substantially the same as embodiment 1 except that:

as shown in fig. 2, eyeshield pastes integral type eye patch, including being used for pasting rectangular portion 4 in four white acupuncture points department, rectangular portion 4's length is 4cm width and is 1cm, bends to form along this one end of rectangular portion 4 and is used for pasting the kink 5 in Jingming acupuncture point department, the distance of the top of kink 5 to rectangular portion 4 bottom is 3cm, the width of kink 5 is 1cm, bend through curved bending to form at the tip along this rectangular portion 4 other end and is used for pasting the circular portion 6 in temple department, the radius of circular portion is 0.5 cm.

Example 5

This embodiment is substantially the same as embodiment 1 except that:

as shown in fig. 3 and 4, the center position of the semicircular part 11 of the eye patch 1 for Jingming acupoint, the middle position of the eye patch 2 for Sibai acupoint, and the center position of the eye patch 3 for Taiyang acupoint are respectively provided with a gentle convex part 7, a cavity 8 is arranged in the middle of the convex part 7, and the height of the convex part 7 is 1 mm. And the cavity 8 is communicated with the top end of the convex part 7 through a through hole, so that the active ingredients are gathered and targeted to be concentrated to be administrated, and the integral molding by using a mold is facilitated.

In order to verify the effect of the eye patch on myopia prevention and control, individual research is firstly carried out.

Application example 1

The examination of a 9-year-old child in a hospital shows that the right eye naked eye vision is 0.6, the left eye naked eye vision is 0.8, the right eye diameter after mydriatic refraction is +0.25DS, and the cylindrical lens is-0.5 DCx 165; left eye sphere diameter 0DS, cylindrical mirror-0.50 DCx 170.

The children are ordered to use the eye patch, and the eye patch is applied for 3 hours (1.5 hours for each eye patch) every night according to the using method of the eye patch, and the eye patch is continuously used for 1 month and then is rechecked, so that the naked eye vision of the right eye is improved to 0.8, and the naked eye vision of the left eye is improved to 1.0.

Continuously insisting on using the eye patch for 5 months, and then performing double examination, wherein the naked eye vision of the right eye is stabilized at 0.8, the naked eye vision of the left eye is stabilized at 1.0, the right eye diameter after mydriasis is tested is +0.25DS, and the cylindrical lens is-0.25 DCx 165; left eye sphere diameter 0DS, cylindrical lens-0.25 DCx 170.

When the eye patch is used for half a year, the children are not myopic, and the astigmatism degrees of the eyes are reduced by 25 degrees respectively compared with the previous astigmatism degrees.

Show that the naked eye eyesight of the children without myopia can be improved after the eye patch is used, and the occurrence of myopia is prevented.

Application example 2

The 14-year-old teenagers go to a hospital to check and find that the right eye naked eye vision is 0.3, the left eye naked eye vision is 0.2, the right eye ball diameter is-1.75 DS and the cylindrical lens is-0.25 DCx180 after mydriatic refraction; left eye sphere diameter-2.00 DS, cylindrical lens-0.50 DCx 180.

The children are advised to prepare the glasses conventionally, the corrected vision of each eye after the glasses are prepared is 1.0, meanwhile, the eye patch is matched to use, according to the use method of the eye patch, the eye patch is applied for 3 hours (each eye patch is used for 1.5 hours) every night, the eye patch is continuously used for 1 month and then is rechecked, and the corrected vision of each eye is 1.0.

And continuously insisting on using the eye patch for 5 months for rechecking, wherein the corrected vision of each eye is 1.0, and the myopia degrees of the two eyes are not increased after optometry.

The increase of the myopia of the teenagers can be controlled by using the eye patch.

In order to further clarify the effect of the eye patch on vision and myopia, a study is carried out.

Comparative example 1

This comparative example is essentially the same as example 1, except that: removing Borneolum Syntheticum.

Comparative example 2

This comparative example is essentially the same as example 1 except that the preparation procedure was as follows:

1) grinding and crushing concha haliotidis according to a set amount, adding 500 parts of water, boiling, decocting for 1 hour by strong fire, decocting for 1-2 hours by slow fire, removing residues, taking juice, and cooling to room temperature to obtain a concha haliotidis extract for later use;

2) weighing periostracum Cicadae and flos Buddlejae according to a set amount, mixing, grinding and crushing, adding water with the content of the periostracum Cicadae and the flos Buddlejae being 4 times that of the flos Buddlejae, heating and boiling, decocting with slow fire for 10-20 min, removing residues, taking juice to obtain decoction, decocting the decoction with an equal amount of clear water for 10-20 min again, removing residues, taking juice, and cooling to room temperature to obtain a mixed extract of the periostracum Cicadae and the flos Buddlejae;

Comparative example 3

This comparative example is essentially the same as example 1, except that:

in the step 2), the cicada slough and the buddleja officinalis are respectively ground and pulverized according to a set amount.

And (2) putting the crushed cicada slough into water with the content 4 times that of the cicada slough, ultrasonically crushing for 5min, heating and boiling, decocting for 10-20 min with slow fire, removing residues, taking juice to obtain a cicada slough decoction, decocting the cicada slough decoction with an equal amount of clear water for 10-20 min, removing residues, taking juice, and cooling to room temperature to obtain the cicada slough extract.

The method comprises the following steps of putting crushed butterflybush flower into water with the content of 4 times of the butterflybush flower, carrying out ultrasonic crushing for 5min, heating and boiling, then decocting with slow fire for 10-20 min, removing slag, taking decoction of the butterflybush flower, decocting the butterflybush flower decoction with an equal amount of clear water for 10-20 min, removing slag, taking the decoction, and cooling to room temperature to obtain the butterflybush flower extract.

In the step 3), the abalone shell extract, the cicada slough extract and the buddleja officinalis extract are uniformly stirred, a certain amount of borneol is ground into powder to be added, and the mixture is uniformly stirred again to obtain the traditional Chinese medicine extract mixed solution.

Comparative example 4

This comparative example is essentially the same as example 5, except that:

convex parts 7 are respectively arranged at the center position of a semicircular part 11 of the eye patch 1 for Jingming acupoint, the middle position of the eye patch 2 for Sibai acupoint and the center position of the eye patch 3 for Taiyang acupoint, the middle of each convex part 7 is of a solid structure, and the height of each convex part 7 is 1 mm.

Application example 3

Grouping standard: the selected age is 6-18 years old, the diopter is between-5.00D and +1.00D, and the reexamination can be carried out according to the requirement.

Exclusion criteria: amblyopia exists in eyes, astigmatism degree exceeds 200 degrees, infection exists in eyes and the periphery of eyes, and the atropine eye ointment is used for a long time (more than 3 months) in recent half a year, so that the requirement of using the eye patch for 3 hours every day cannot be met.

The grouping method comprises the following steps: the children and teenagers in 72 visits are randomly selected in an ophthalmic outpatient clinic and divided into two groups of myopia (36 persons) and non-myopia (36 persons) according to diopter, and each group is randomly divided into 6 groups: blank control group, test group 1, test group 2, control eye patch group 1, control eye patch group 2 and control

eye patch group

3, 6 persons each.

Sphere diameter < -0.5D defines myopia, and sphere diameter > -0.5D defines non-myopia.

The random method comprises the following steps: a random number table method is used.

The intervention method of each group is set as follows;

blank control group: no eye patch is used.

Test group 1: the eye patch prepared in example 1 was used.

Test group 2: the eye patch prepared in example 5 was used.

Control eye patch group 1: the eye patch prepared in comparative example 1 was used.

Control eye patch group 2: the eye patch prepared in comparative example 2 was used.

Control eye patch group 3: the eye patch prepared in comparative example 3 was used.

Control eye patch group 4: the eye patch prepared in comparative example 4 was used.

The test group and the control eye patch group were applied with 2 eye patches at 6 o' clock every night for 1.5 hours in total for 3 hours, according to the application method of the eye patches.

The trial had 2 visits, baseline and 6 months after-visit, respectively. Both visits required a prescription (mydriatic prescription within 14 years of age, non-mydriatic at 14-18 years of age) and a general visual examination. Only right eye data was collected.

Statistical analysis: statistical analysis was performed using SPSS software 17.0, with P <0.05 indicating that the difference was statistically significant. The test results are shown in the following table:

TABLE 1 eye patch for treating vision of teenagers

In the above table, "change in vision" refers to the difference between the follow-up vision and the baseline vision after 6 months, with negative values indicating decreased vision and positive values indicating increased vision.

The results show that for all subjects without myopia and myopia, the vision of the blank control group and the control eye patch group after 6 months is remarkably reduced or not improved compared with the baseline, and the vision of the test group 1 and the test group 2 is remarkably improved after the eye patch is used. The patent eye patch has the function of improving eyesight in the young without myopia and the young with myopia. The test group 2 also has a significantly improved visual effect compared to the control eye patch group 4, and it was confirmed that the hollow convex portions 7 can be attached, and have a targeted drug permeation effect and an improved visual effect.

TABLE 2 action of eye patch on myopia of teenagers

In the above table, "change in spherical diameter" means change in spherical diameter at follow-up visit after 6 months, and a negative value indicates an increase toward myopia.

The results show that the myopia increase is greater than that of the test group after 6 months from the baseline in the control group without myopia and the control eye patch group; during the period, all subjects in the myopia-free test group have no myopia after the return visit after 6 months, which shows that the eye patch can effectively control the occurrence of myopia. The myopia increase of the myopia blank control group and the myopia control eye patch group is also obviously greater than that of the test group after 6 months. The myopia degree increase can be reduced after the teenagers use the eye patch, and the myopia development can be controlled. The test group 2 also has a significantly improved visual effect compared to the control eye patch group 4, and it was confirmed that the hollow convex portion 7 can be attached, and has a targeted drug permeation effect, and an increase in myopia number can be reduced.

In conclusion, after the eye patch is used, the eyesight of teenagers can be improved, the occurrence and the development of myopia can be controlled, and adverse reactions are not generated in the using process.

The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides an eyeshield subsides with myopia prevention and control function which characterized in that: the eye protection patch takes natural hydrogel as a carrier, and the components attached in the natural hydrogel comprise borneol, an extract of abalone shell, and a mixed extract of cicada slough and buddleja officinalis.

2. The eye patch with myopia prevention and control function of claim 1, wherein: the natural hydrogel comprises natural sodium alginate.

3. The eye patch with myopia prevention and control function of claim 2, wherein: the natural hydrogel further comprises sodium glycerophosphate, polyvinyl alcohol and chitosan.

4. The eye patch with the function of preventing and controlling myopia according to claim 3, wherein the natural hydrogel comprises the following attached components in parts by weight:

0.5 to 0.8 portion of borneol,

5. The eye patch with myopia prevention and control function of claim 4, wherein: the natural hydrogel comprises, by weight, 4-5 parts of natural sodium alginate, 6-8 parts of sodium glycerophosphate, 6-8 parts of polyvinyl alcohol and 2-4 parts of chitosan.

6. The eye patch with myopia prevention and control function of any one of claims 1-5, wherein: the eye protection paste is divided into a Jingming acupoint eye paste (1), a Sibai acupoint eye paste (2) and a Taiyang acupoint eye paste (3) which are separated;

the Jingming point eye patch (1) comprises a rectangular part (10) and a semicircular part (11) arranged on one side of the rectangular part (10);

the four-white acupoint eye patch (2) is in a strip shape with two arc ends;

the temple eye patch (3) is round.

7. The eye patch with myopia prevention and control function of any one of claims 1-5, wherein: the eye protection patch is an integrated eye patch and comprises a long strip portion (4) used for being pasted at the four white acupoints, a bent portion (5) used for being pasted at the Jingming acupoint is formed by bending one end of the long strip portion (4), and a round portion (6) used for being pasted at the temple acupoint is formed by bending the other end of the long strip portion (4) at the end portion.

8. The eye protective patch with myopia prevention and control function of any one of claim 6, wherein: the eye patch is characterized in that a gentle convex part (7) is respectively arranged at the center of a semicircular part (11) of the Jingming acupoint eye patch (1), the middle of the Sibai acupoint eye patch (2) and the center of the Taiyang acupoint eye patch (3), a cavity (8) is arranged in the middle of the convex part (7), and the height of the convex part (7) is 0.1-1.5 mm.

9. The eye patch with the myopia prevention and control function of any one of claims 1-5, wherein the preparation method comprises the following steps:

10. The eye patch with the myopia prevention and control function of claim 5, wherein the preparation method comprises the following steps:

2) weighing periostracum Cicadae and flos Buddlejae according to a set amount, mixing, grinding and crushing, adding water with the content of the periostracum Cicadae and flos Buddlejae being 4 times that of the flos Buddlejae, ultrasonically crushing for 5-10 min, heating and boiling, decocting for 10-20 min with slow fire, removing residues, taking juice to obtain a decoction, re-decocting the decoction and an equal amount of clear water for 10-20 min, removing residues, taking juice, and cooling to obtain a mixed extract of the periostracum Cicadae and the flos Buddle;